Florian Krotz

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi NAD(P)H oxidase-dependent platelet superoxide anion release increases platelet recruitment
    Florian Krotz
    Institute of Physiology and the Department of Internal Medicine, Ludwig Maximilians University Munich, Schillerstr 44, 80336 Munich, Germany
    Blood 100:917-24. 2002
  2. ncbi Intracoronary brachytherapy--clinical state and pathophysiological considerations
    Florian Krotz
    Institute of Physiology, Ludwig Maximilians University, Schillerstr 44, 80336 Munich, Germany
    Curr Pharm Des 11:421-33. 2005
  3. ncbi Membrane-potential-dependent inhibition of platelet adhesion to endothelial cells by epoxyeicosatrienoic acids
    Florian Krotz
    Institute of Physiology, Medizinische Poliklinik Innenstadt, Ludwig Maximilians University, Munchen, Germany
    Arterioscler Thromb Vasc Biol 24:595-600. 2004
  4. ncbi Magnetofection potentiates gene delivery to cultured endothelial cells
    Florian Krotz
    Institute of Physiology, Medizinische Poliklinik Innenstadt, Germany
    J Vasc Res 40:425-34. 2003
  5. ncbi The tyrosine phosphatase, SHP-1, is a negative regulator of endothelial superoxide formation
    Florian Krotz
    Institute of Physiology, Ludwig Maximilians University, Munich, Germany
    J Am Coll Cardiol 45:1700-6. 2005
  6. ncbi Magnetofection--a highly efficient tool for antisense oligonucleotide delivery in vitro and in vivo
    Florian Krotz
    Institute of Physiology, Munich, Germany
    Mol Ther 7:700-10. 2003
  7. ncbi Selective COX-2 inhibitors and risk of myocardial infarction
    Florian Krotz
    Institute of Cardiology, Medical Polyclinic, Ludwig Maximilians University, Munich, Germany
    J Vasc Res 42:312-24. 2005
  8. ncbi Depolarization of endothelial cells enhances platelet aggregation through oxidative inactivation of endothelial NTPDase
    Florian Krotz
    Institute of Physiology, Munchen, Germany
    Arterioscler Thromb Vasc Biol 22:2003-9. 2002
  9. ncbi Sustained platelet activation following intracoronary beta irradiation
    Florian Krotz
    Institute of Physiology, Ludwig Maximilians University, Munich, Germany
    Am J Cardiol 90:1381-4. 2002
  10. ncbi Reactive oxygen species: players in the platelet game
    Florian Krotz
    Institute of Physiology, Cardiology Division, Medizinische Poliklinik Innenstadt, Ludwig Maximilians University, Ziemssenstr 1, 80336 Munich, Germany
    Arterioscler Thromb Vasc Biol 24:1988-96. 2004

Collaborators

Detail Information

Publications37

  1. ncbi NAD(P)H oxidase-dependent platelet superoxide anion release increases platelet recruitment
    Florian Krotz
    Institute of Physiology and the Department of Internal Medicine, Ludwig Maximilians University Munich, Schillerstr 44, 80336 Munich, Germany
    Blood 100:917-24. 2002
    ..These results strongly suggest that collagen activation induces NAD(P)H oxidase-dependent O release in platelets, which in turn enhances availability of released ADP, resulting in increased platelet recruitment...
  2. ncbi Intracoronary brachytherapy--clinical state and pathophysiological considerations
    Florian Krotz
    Institute of Physiology, Ludwig Maximilians University, Schillerstr 44, 80336 Munich, Germany
    Curr Pharm Des 11:421-33. 2005
    ..Both angiographic and clinical results of randomised and observational studies will be updated in detail...
  3. ncbi Membrane-potential-dependent inhibition of platelet adhesion to endothelial cells by epoxyeicosatrienoic acids
    Florian Krotz
    Institute of Physiology, Medizinische Poliklinik Innenstadt, Ludwig Maximilians University, Munchen, Germany
    Arterioscler Thromb Vasc Biol 24:595-600. 2004
    ..In many vessels, they are an endothelium-derived hyperpolarizing factor (EDHF). However, it is unknown whether they act as an EDHF on platelets and whether this has functional consequences...
  4. ncbi Magnetofection potentiates gene delivery to cultured endothelial cells
    Florian Krotz
    Institute of Physiology, Medizinische Poliklinik Innenstadt, Germany
    J Vasc Res 40:425-34. 2003
    ..5% of cells. MF is an effective tool for pDNA transfection of endothelial cells allowing high efficiencies. It may be of great use for investigating protein function in cell culture experiments...
  5. ncbi The tyrosine phosphatase, SHP-1, is a negative regulator of endothelial superoxide formation
    Florian Krotz
    Institute of Physiology, Ludwig Maximilians University, Munich, Germany
    J Am Coll Cardiol 45:1700-6. 2005
    ..We investigated the role of SH2-domain containing phosphatase-1 (SHP-1) in endothelial reduced nicotinamide adenine dinucleotide (phosphate) (NAD[P]H)-oxidase-dependent oxidant production...
  6. ncbi Magnetofection--a highly efficient tool for antisense oligonucleotide delivery in vitro and in vivo
    Florian Krotz
    Institute of Physiology, Munich, Germany
    Mol Ther 7:700-10. 2003
    ..Magnetofection is an ideal tool for delivery of functionally active ODN to difficult-to-transfect cells to study gene/protein function and a promising strategy for targeted ODN delivery in vivo...
  7. ncbi Selective COX-2 inhibitors and risk of myocardial infarction
    Florian Krotz
    Institute of Cardiology, Medical Polyclinic, Ludwig Maximilians University, Munich, Germany
    J Vasc Res 42:312-24. 2005
    ..It describes coxibs that are current ly available, evaluates the current knowledge on the risk of atherothrombotic events associated with their intake and critically discusses the consequences that should be drawn from these insights...
  8. ncbi Depolarization of endothelial cells enhances platelet aggregation through oxidative inactivation of endothelial NTPDase
    Florian Krotz
    Institute of Physiology, Munchen, Germany
    Arterioscler Thromb Vasc Biol 22:2003-9. 2002
    ..The objective of this study was to investigate whether depolarization of cultured endothelial cells (human umbilical vein endothelial cells, HUVECs) affects their ectonucleotidase activity through superoxide (O2-) production...
  9. ncbi Sustained platelet activation following intracoronary beta irradiation
    Florian Krotz
    Institute of Physiology, Ludwig Maximilians University, Munich, Germany
    Am J Cardiol 90:1381-4. 2002
  10. ncbi Reactive oxygen species: players in the platelet game
    Florian Krotz
    Institute of Physiology, Cardiology Division, Medizinische Poliklinik Innenstadt, Ludwig Maximilians University, Ziemssenstr 1, 80336 Munich, Germany
    Arterioscler Thromb Vasc Biol 24:1988-96. 2004
    ....
  11. ncbi Safety and mechanisms of intracoronary manual stepping brachytherapy as gained from serial angiographic and intravascular ultrasound studies
    Thomas M Schiele
    Cardiology Division, Medizinische Klinik Innenstadt, and the Institute of Physiology, University of Munich, Munich, Germany
    Am J Cardiol 90:1385-8. 2002
  12. ncbi Selective inhibition of cyclooxygenase-2 enhances platelet adhesion in hamster arterioles in vivo
    Martin A Buerkle
    Institute of Physiology, Medizinische Poliklinik Innenstadt, Ludwig Maximilians University, Munich, Germany
    Circulation 110:2053-9. 2004
    ..However, direct proof of prothrombotic effects of these drugs is lacking. We investigated in the microcirculation in vivo whether selective inhibition of Cox-2 induces platelet activation...
  13. ncbi Three-year clinical follow-up after strontium-90/yttrium-90 beta-irradiation for the treatment of in-stent coronary restenosis
    Verena Baierl
    Division of Cardiology, Department of Medicine, Medizinische Klinik und Poliklinik, University Hospital Campus Innenstadt, Munich, Germany
    Am J Cardiol 96:1399-403. 2005
    ..083), and 35.8% (p = 0.003), respectively. In conclusion, these results indicate a delayed and, even in the third year after the index procedure, continued restenotic process after beta irradiation of in-stent restenotic lesions...
  14. ncbi Evolution of angiographic restenosis rate and late lumen loss after intracoronary beta radiation for in-stent restenotic lesions
    Thomas M Schiele
    Cardiology Division, Department of Medicine, Medizinische Klinik und Poliklinik Innenstadt, University Hospital, Munich, Germany
    Am J Cardiol 93:836-42. 2004
    ..17 +/- 0.29 mm; 12 to 24 months: 0.11 +/- 0.20 mm). Restenosis after angioplasty and beta-irradiation of in-stent restenotic lesions is not complete within 6 months but is sustained with a gradual decrease over 24 months...
  15. ncbi Differential regulation of xanthine and NAD(P)H oxidase by hypoxia in human umbilical vein endothelial cells. Role of nitric oxide and adenosine
    Hae Young Sohn
    Medizinische Poliklinik Innenstadt, Ludwig Maximilians University Munich, Ziemssenstrasse 1, 80336, Munich, Germany
    Cardiovasc Res 58:638-46. 2003
    ..We further studied whether enzyme activities can be modified by NO and adenosine during hypoxic treatment...
  16. doi A sulfaphenazole-sensitive EDHF opposes platelet-endothelium interactions in vitro and in the hamster microcirculation in vivo
    Florian Krotz
    Cardiology Division, Medizinische Poliklinik, Ludwigs Maximilians Universität, Ziemssenstr 1, Munich 80336, Germany
    Cardiovasc Res 85:542-50. 2010
    ..Since platelets express the same channels, we tested whether EDHF hyperpolarizes platelets and exerts an antithrombotic function in vivo...
  17. doi Late and very late catch-up after 90Sr/90Y beta-irradiation for the treatment of coronary in-stent restenosis
    Thomas M Schiele
    Cardiology Division, Department of Medicine, Medizinische Klinik und Poliklinik, University Hospital Campus Innenstadt, Munich, Germany
    Acute Card Care 13:9-13. 2011
    ....
  18. ncbi Crucial role of local peroxynitrite formation in neutrophil-induced endothelial cell activation
    Hae Young Sohn
    Division of Cardiology, Medizinische Klinik Innenstadt, Ludwig Maximilians University Munich, Germany
    Cardiovasc Res 57:804-15. 2003
    ..We particularly studied whether a significantly higher redox-stress can be found in those endothelial cells directly adjacent to an activated neutrophil...
  19. doi Site directed vascular gene delivery in vivo by ultrasonic destruction of magnetic nanoparticle coated microbubbles
    Hanna Mannell
    Walter Brendel Centre of Experimental Medicine, Ludwig Maximilians University, Munich, Germany
    Nanomedicine 8:1309-18. 2012
    ..This resulted in a significant enhancement in site specific gene delivery compared with the conventional microbubble technique. Thus, this technology may have promising therapeutic potential...
  20. doi Five-year clinical follow-up after sirolimus-eluting stent implantation for the treatment of coronary in-stent restenosis
    Thomas M Schiele
    Department of Medicine, Division of Cardiology, Medizinische Klinik und Poliklinik, University Hospital Campus Innenstadt, Munich, Germany
    Coron Artery Dis 22:188-93. 2011
    ..Late vessel failure by restenosis or thrombosis is a potential limitation of drug-eluting stent implantation...
  21. ncbi Inhibition of the tyrosine phosphatase SHP-2 suppresses angiogenesis in vitro and in vivo
    Hanna Mannell
    Institute of Physiology, Medical Policlinic, Ludwig Maximilians University, Munich, Germany
    J Vasc Res 45:153-63. 2008
    ..Thus, SHP-2 exhibits a pivotal role in angiogenesis and may represent an interesting target for therapeutic approaches controlling vessel growth...
  22. doi Hydrogen sulfide-releasing aspirin derivative ACS14 exerts strong antithrombotic effects in vitro and in vivo
    Joachim Pircher
    Medizinische Klinik und Poliklinik IV, Klinikum der LMU, Munchen, Germany
    Arterioscler Thromb Vasc Biol 32:2884-91. 2012
    ..Here, we compared the platelet inhibitory effects of the H(2)S-releasing aspirin derivative ACS14 with its mother compound aspirin to analyze additional effects on platelets...
  23. ncbi Mycophenolate acid inhibits endothelial NAD(P)H oxidase activity and superoxide formation by a Rac1-dependent mechanism
    Florian Krotz
    Institute of Physiology, Medical Policlinic, Ludwig Maximilians University, Munich, Germany
    Hypertension 49:201-8. 2007
    ....
  24. doi Targeted endothelial gene delivery by ultrasonic destruction of magnetic microbubbles carrying lentiviral vectors
    Hanna Mannell
    Walter Brendel Centre of Experimental Medicine, Schillerstrasse 44, 80336 Munich, Germany
    Pharm Res 29:1282-94. 2012
    ..By combining ultrasound mediated microbubble destruction with site specific magnetic targeting of lentiviruses, we aimed to develop a technique suitable for systemic application...
  25. pmc Antiplatelet drugs in cardiological practice: established strategies and new developments
    Florian Krotz
    Cardiology, Medical Policlinic, Ludwig Maximilians Universitat, Ziemssenstr 1, 80336 Munchen, Germany
    Vasc Health Risk Manag 4:637-45. 2008
    ..This article summarizes the relevant pathophysiology of platelet activation, presents current concepts in antiplatelet drug therapy, and highlights the role of platelets in vascular diseases apart from atherothrombosis...
  26. ncbi Stereospecific and redox-sensitive increase in monocyte adhesion to endothelial cells by homocysteine
    Otilia Postea
    Medical Policlinic, Ludwig Maximilians University Munich, Germany
    Arterioscler Thromb Vasc Biol 26:508-13. 2006
    ..hy 926 and primary human umbilical vein EC [HUVEC]) and the monocytic cell line THP-1, and the impact of vascular oxidant stress and redox-sensitive signaling pathways on these events...
  27. doi Response of VEGF to activation of viral receptors and TNFα in human mesangial cells
    Monika Merkle
    Medizinische Klinik und Poliklinik IV, Klinikum der LMU, Munich, Germany
    Mol Cell Biochem 370:151-61. 2012
    ..TNFα and MCP-1 are seemingly important in amplifying VEGF effects in the setting of virally induced inflammation, with TNFα being also able to induce other mediators of glomerular pathology in GN...
  28. doi Suppression of DNA-PKcs enhances FGF-2 dependent human endothelial cell proliferation via negative regulation of Akt
    Hanna Mannell
    Cardiology, Medical Policlinic, Ludwig Maximilians University, Ziemssenstrasse 1, 80336 Munich, Germany
    Cell Signal 22:88-96. 2010
    ..Our findings indicate DNA-PK as an important enzyme maintaining the quiescent endothelial phenotype by actively inhibiting Akt thus restraining endothelial cell proliferation preventing excessive growth...
  29. doi ARNO regulates VEGF-dependent tissue responses by stabilizing endothelial VEGFR-2 surface expression
    Hanna K Mannell
    Walter Brendel Centre for Experimental Medicine, Munich, Germany
    Cardiovasc Res 93:111-9. 2012
    ..However, a role for ARNO in VEGF-dependent endothelial processes has so far not been documented. Therefore, we investigated whether ARNO has a role in VEGF-dependent activation of endothelial cells and thus vessel permeability...
  30. ncbi Prothrombotic potential of NSAID in ischemic heart disease
    Florian Krotz
    Institute of Cardiology, Medical Policlinic, Ludwig Maximilians University, Ziemssenstr 1, 80336 Munich, Germany
    Mini Rev Med Chem 6:1351-5. 2006
    ..This review evaluates potential prothrombotic effects of NSAID in vascular ischemic disease in comparison to low-dose aspirin and selective COX-2 inhibitors and discusses pathophysiological backgrounds for such observations...
  31. ncbi Expression of HIF-1alpha in injured arteries controls SDF-1alpha mediated neointima formation in apolipoprotein E deficient mice
    Ela Karshovska
    Division of Cardiology, Medizinische Poliklinik, University of Munich, Pettenkoferstrasse 8a, 80336 Munich, Germany
    Arterioscler Thromb Vasc Biol 27:2540-7. 2007
    ..Because HIF-1alpha can be activated under normoxic conditions in smooth muscle cells (SMCs) by platelet products, we investigated the role of HIF-1alpha in SDF-1alpha-mediated neointima formation after vascular injury...
  32. pmc The endothelial tyrosine phosphatase SHP-1 plays an important role for vascular haemostasis in TNFα -induced inflammation in vivo
    Elisabeth Koch
    Medizinische Klinik und Poliklinik IV, Innenstadt, Ludwig Maximilians Universitat Munchen, Ziemssenstr 1, 80336 Munich, Germany
    Mediators Inflamm 2013:279781. 2013
    ..In this study we investigated the influence of SHP-1 on platelet-endothelium interaction and arterial thrombosis in TNFα -induced endothelial inflammation in vivo...
  33. doi CD34+CD140b+ cells and circulating CXCL12 correlate with the angiographically assessed severity of cardiac allograft vasculopathy
    Andreas Schober
    Medizinische Poliklinik Innenstadt, Kardiologie, University of Munich, Munich, Germany
    Eur Heart J 32:476-84. 2011
    ..We sought to determine whether circulating vascular progenitor cells, such as endothelial progenitor cells (EPCs) or smooth muscle progenitor cells (SPCs), were associated with the severity of cardiac allograft vasculopathy (CAV)...
  34. ncbi Cyclooxygenase inhibition and atherothrombosis
    Hae Young Sohn
    Institute of Cardiology, Medical Policlinic, Ludwig Maximilians University, Ziemssenstr 1, 80336 Munich, Germany
    Curr Drug Targets 7:1275-84. 2006
    ..It specifically discusses the question, whether all selective COX-2 inhibitors may have an intrinsic risk of enhancing the risk of atherothrombosis...
  35. ncbi A Review on the risk of myocardial infarction associated with the NSAID diclofenac
    Florian Krotz
    Cardiology, Medical Policlinic, University Hospital Munich, Ludwig Maximilians University, Ziemssenstr 1, 80336 Munchen, Germany
    Cardiovasc Hematol Disord Drug Targets 10:53-65. 2010
    ..In this review, we summarize the clinical evidence about adverse atherothrombotic events associated with diclofenac and dissect the pharmacological reasons beyond this phenomenon in comparison to other tNSAID...
  36. doi Novel role of toll-like receptor 3, RIG-I and MDA5 in poly (I:C) RNA-induced mesothelial inflammation
    Markus Wornle
    Medical Policlinic, Ludwig Maximilians University, Pettenkoferstrasse 8a, 80336, Munich, Germany
    Mol Cell Biochem 322:193-206. 2009
    ..This novel finding of functional expression of viral sensors on human MC may indicate a novel link between viral infections and mesothelial inflammation and indicates a pathophysiologic role of viral receptors in these processes...
  37. doi Bioactivation of dermal scaffolds with a non-viral copolymer-protected gene vector
    Ann K Reckhenrich
    Institute of Experimental Oncology, Technische Universitat Munchen, Munich, Germany
    Biomaterials 32:1996-2003. 2011
    ..In this work we show that the bioactivation of collagen scaffolds with COPROGs presents a new technology that allows a local release of therapeutic proteins thus enhancing the regenerative potential in vivo...