Nicolaus Kroger

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. ncbi request reprint Clinical impact of human Jurkat T-cell-line-derived antithymocyte globulin in multiple myeloma patients undergoing allogeneic stem cell transplantation
    Francis Ayuk
    Dept of Stem cell Transplantation, University Medical Center Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Haematologica 93:1343-50. 2008
  2. ncbi request reprint Dynamic of bone marrow fibrosis regression predicts survival after allogeneic stem cell transplantation for myelofibrosis
    Nicolaus Kroger
    Department of Stem Cell Transplantation, University Medical Center Hamburg Eppendorf, Hamburg, Germany Electronic address
    Biol Blood Marrow Transplant 20:812-5. 2014
  3. pmc Impact of the NK cell receptor LIR-1 (ILT-2/CD85j/LILRB1) on cytotoxicity against multiple myeloma
    Silke Heidenreich
    Clinic for Stem Cell Transplantation, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Dev Immunol 2012:652130. 2012
  4. pmc Comparison of allogeneic stem cell transplantation and non-transplant approaches in elderly patients with advanced myelodysplastic syndrome: optimal statistical approaches and a critical appraisal of clinical results using non-randomized data
    Ronald Brand
    Department of Statistics, University Medical Center, Leiden, The Netherlands
    PLoS ONE 8:e74368. 2013
  5. doi request reprint Allogeneic stem cell transplantation for older advanced MDS patients: improved survival with young unrelated donor in comparison with HLA-identical siblings
    N Kroger
    Department for Stem Cell Transplantation, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Leukemia 27:604-9. 2013
  6. doi request reprint Toxicity-reduced, myeloablative allograft followed by lenalidomide maintenance as salvage therapy for refractory/relapsed myeloma patients
    N Kroger
    Department of Stem Cell Transplantation, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Bone Marrow Transplant 48:403-7. 2013
  7. ncbi request reprint Impact of high-risk cytogenetics and achievement of molecular remission on long-term freedom from disease after autologous-allogeneic tandem transplantation in patients with multiple myeloma
    Nicolaus Kroger
    Department of Stem Cell Transplantation, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Biol Blood Marrow Transplant 19:398-404. 2013
  8. doi request reprint Allogeneic stem cell transplantation for elderly patients with myelodysplastic syndrome
    Nicolaus Kroger
    Department of Stem Cell Transplantation, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Blood 119:5632-9. 2012
  9. ncbi request reprint Rabbit-IgG levels in patients receiving thymoglobulin as part of conditioning before unrelated donor stem cell transplantation
    Nicolaus Kroger
    Bone Marrow Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Haematologica 90:869B. 2005
  10. ncbi request reprint Autologous-allogeneic tandem stem cell transplantation in patients with multiple myeloma
    Nicolaus Kroger
    Bone Marrow Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Leuk Lymphoma 46:813-21. 2005

Detail Information

Publications129 found, 100 shown here

  1. ncbi request reprint Clinical impact of human Jurkat T-cell-line-derived antithymocyte globulin in multiple myeloma patients undergoing allogeneic stem cell transplantation
    Francis Ayuk
    Dept of Stem cell Transplantation, University Medical Center Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Haematologica 93:1343-50. 2008
    ..In vitro studies suggest that antithymocyte globulin, besides causing T-cell depletion, has strong anti-myeloma activity...
  2. ncbi request reprint Dynamic of bone marrow fibrosis regression predicts survival after allogeneic stem cell transplantation for myelofibrosis
    Nicolaus Kroger
    Department of Stem Cell Transplantation, University Medical Center Hamburg Eppendorf, Hamburg, Germany Electronic address
    Biol Blood Marrow Transplant 20:812-5. 2014
    ..014) or platelets (P = .018). Rapid BMF regression after reduced-intensity conditioning allo-SCT resulted in a favorable survival independent of IPSS risk score at transplantation...
  3. pmc Impact of the NK cell receptor LIR-1 (ILT-2/CD85j/LILRB1) on cytotoxicity against multiple myeloma
    Silke Heidenreich
    Clinic for Stem Cell Transplantation, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Dev Immunol 2012:652130. 2012
    ..To our knowledge, this work provides the first investigation of the inhibitory capability of LIR-1 in NK-92-mediated cytotoxicity against MM and the first functional evaluation of LIR-1 on MM and LBCL...
  4. pmc Comparison of allogeneic stem cell transplantation and non-transplant approaches in elderly patients with advanced myelodysplastic syndrome: optimal statistical approaches and a critical appraisal of clinical results using non-randomized data
    Ronald Brand
    Department of Statistics, University Medical Center, Leiden, The Netherlands
    PLoS ONE 8:e74368. 2013
    ..Nonetheless no conclusion can be reached from a clinical point of view without assumptions which are by their very nature untestable unless all patients would be followed from diagnosis. ..
  5. doi request reprint Allogeneic stem cell transplantation for older advanced MDS patients: improved survival with young unrelated donor in comparison with HLA-identical siblings
    N Kroger
    Department for Stem Cell Transplantation, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Leukemia 27:604-9. 2013
    ..65 (95% CI: 0.45-0.95), P=0.03), which should be considered in donor selection for older patients...
  6. doi request reprint Toxicity-reduced, myeloablative allograft followed by lenalidomide maintenance as salvage therapy for refractory/relapsed myeloma patients
    N Kroger
    Department of Stem Cell Transplantation, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Bone Marrow Transplant 48:403-7. 2013
    ..Toxicity-reduced myeloablative allograft followed by lenalidomide maintenance is feasible and effective in relapsed patients with MM, but the induction of GvHD should be considered...
  7. ncbi request reprint Impact of high-risk cytogenetics and achievement of molecular remission on long-term freedom from disease after autologous-allogeneic tandem transplantation in patients with multiple myeloma
    Nicolaus Kroger
    Department of Stem Cell Transplantation, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Biol Blood Marrow Transplant 19:398-404. 2013
    ..These results suggest that auto-allo tandem SCT may overcome the negative prognostic effect of del(17p13) and/or t(4;14) and that achievement of molecular remission resulted in long-term freedom from disease...
  8. doi request reprint Allogeneic stem cell transplantation for elderly patients with myelodysplastic syndrome
    Nicolaus Kroger
    Department of Stem Cell Transplantation, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Blood 119:5632-9. 2012
    ....
  9. ncbi request reprint Rabbit-IgG levels in patients receiving thymoglobulin as part of conditioning before unrelated donor stem cell transplantation
    Nicolaus Kroger
    Bone Marrow Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Haematologica 90:869B. 2005
  10. ncbi request reprint Autologous-allogeneic tandem stem cell transplantation in patients with multiple myeloma
    Nicolaus Kroger
    Bone Marrow Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Leuk Lymphoma 46:813-21. 2005
    ....
  11. ncbi request reprint Comparison between antithymocyte globulin and alemtuzumab and the possible impact of KIR-ligand mismatch after dose-reduced conditioning and unrelated stem cell transplantation in patients with multiple myeloma
    Nicolaus Kroger
    Bone Marrow Transplantation, University Hospital Hamburg, Hamburg, Germany
    Br J Haematol 129:631-43. 2005
    ..0001). We conclude that alemtuzumab produced less acute GvHD, but higher probability of relapse. The data implicated a major role of KIR-ligand mismatched transplantation in multiple myeloma...
  12. doi request reprint Unrelated stem cell transplantation for patients with multiple myeloma
    Nicolaus Kroger
    Clinic for Stem Cell Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Curr Opin Hematol 17:538-43. 2010
    ....
  13. ncbi request reprint Pilot study of reduced-intensity conditioning followed by allogeneic stem cell transplantation from related and unrelated donors in patients with myelofibrosis
    Nicolaus Kroger
    Unit of Bone Marrow Transplantation, University Hospital Hamburg, D 20246 Hamburg, Germany
    Br J Haematol 128:690-7. 2005
    ..After a median follow-up of 22 months (range, 4-59), the 3-year estimated overall and disease-free survival was 84% (95% CI: 67-100%)...
  14. ncbi request reprint Stem cell transplantation from identical twins in patients with myelodysplastic syndromes
    N Kroger
    Bone Marrow Transplantation, University Hospital Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Bone Marrow Transplant 35:37-43. 2005
    ..6 (95% CI: 0.4-1.0; P=0.07). We conclude that twin transplantation in MDS/sAML is associated with a similar relapse risk, a lower TRM and a trend for better overall survival in comparison to transplantation from HLA-identical siblings...
  15. ncbi request reprint Relapse to prior autograft and chronic graft-versus-host disease are the strongest prognostic factors for outcome of melphalan/fludarabine-based dose-reduced allogeneic stem cell transplantation in patients with multiple myeloma
    Nicolaus Kroger
    Bone Marrow Transplantation, University Hospital Hamburg, Germany
    Biol Blood Marrow Transplant 10:698-708. 2004
    ....
  16. ncbi request reprint Low-dose thalidomide and donor lymphocyte infusion as adoptive immunotherapy after allogeneic stem cell transplantation in patients with multiple myeloma
    Nicolaus Kroger
    Department of Bone Marrow Transplantation, University Hospital Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Blood 104:3361-3. 2004
    ..The 2-year estimated overall and progression-free survival were 100% and 84%, respectively. Adoptive immunotherapy with low-dose thalidomide and DLI induces a strong antimyeloma effect with low incidence of graft versus host disease...
  17. ncbi request reprint [Allogenic stem cell transplantation following dose-reduced conditioning in patients with hematologic systemic diseases or solid tumors]
    N Kroger
    Knochenmarktransplantation, Universitatsklinikum Hamburg Eppendorf
    Ther Umsch 61:385-8. 2004
    ..Therefore, dose-reduced conditioning followed by allogeneic stem cell transplantation can be offered to older and more debilitated patients who were no candidates for standard allogeneic stem cell transplantation...
  18. pmc Allogeneic stem cell transplantation for myelodysplastic syndromes with bone marrow fibrosis
    Nicolaus Kroger
    Department for Stem Cell Transplantation, University Medical Center, Hamburg Eppendorf, Martinistraße 52 D 20246, Hamburg, Germany
    Haematologica 96:291-7. 2011
    ..Bone marrow fibrosis in patients with myelodysplastic syndrome is associated with a poor outcome, but whether the outcome after allogeneic stem cell transplantation is related to the degree of bone marrow fibrosis is unknown...
  19. ncbi request reprint Low number of donor activating killer immunoglobulin-like receptors (KIR) genes but not KIR-ligand mismatch prevents relapse and improves disease-free survival in leukemia patients after in vivo T-cell depleted unrelated stem cell transplantation
    Nicolaus Kroger
    Bone Marrow Transplantation, University Hospital Hamburg, Hamburg, Germany
    Transplantation 82:1024-30. 2006
    ....
  20. ncbi request reprint Autologous stem cell transplantation for therapy-related acute myeloid leukemia and myelodysplastic syndrome
    N Kroger
    Bone Marrow Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Bone Marrow Transplant 37:183-9. 2006
    ..Autologous transplantation may cure a substantial number of patients with treatment-related MDS/AML, especially if they are in CR1 and of younger age...
  21. doi request reprint HLA-mismatched unrelated donors as an alternative graft source for allogeneic stem cell transplantation after antithymocyte globulin-containing conditioning regimen
    Nicolaus Kroger
    Department of Stem Cell Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Biol Blood Marrow Transplant 15:454-62. 2009
    ..013) (P = .004) and bad-risk disease (HR 1.975) (P < .001) were independent risk factors for DFS. In conclusion, pretransplant ATG allows allogeneic SCT from unrelated donors with HLA disparities...
  22. pmc Risk factors for therapy-related myelodysplastic syndrome and acute myeloid leukemia treated with allogeneic stem cell transplantation
    Nicolaus Kroger
    Dept for Stem Cell Transplantation, University Hospital Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Haematologica 94:542-9. 2009
    ..After successful treatment of malignant diseases, therapy-related myelodysplastic syndrome and acute myeloid leukemia have emerged as significant problems...
  23. ncbi request reprint Unrelated stem cell transplantation after reduced intensity conditioning for patients with multiple myeloma relapsing after autologous transplantation
    Nicolaus Kroger
    University Hospital Hamburg Eppendorf, Germany
    Br J Haematol 148:323-31. 2010
    ..02). We conclude that optimal donor selection is mandatory for a low non-relapse mortality and high relapse incidence, which remains a major concern, should be improved by including post-transplant strategies to upgrade remission status...
  24. doi request reprint Choosing between stem cell therapy and drugs in myelofibrosis
    N Kroger
    Department of Stem Cell Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Leukemia 22:474-86. 2008
    ..The potential for continued improvements in both medical and transplant therapy suggests that for the immediate future the optimal choices for an individual patient will remain potentially volatile and present complex decisions...
  25. doi request reprint Post-transplant immunotherapy with donor-lymphocyte infusion and novel agents to upgrade partial into complete and molecular remission in allografted patients with multiple myeloma
    Nicolaus Kroger
    Department for Stem Cell Transplantation, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Exp Hematol 37:791-8. 2009
    ..To investigate post-transplant immunotherapy with escalating donor-lymphocyte infusions (DLI) and novel agents (thalidomide, bortezomib, and lenalidomide) to target complete remission (CR)...
  26. ncbi request reprint Mini-Midi-Maxi? How to harness the graft-versus-myeloma effect and target molecular remission after allogeneic stem cell transplantation
    N Kroger
    Department for Stem Cell Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Leukemia 21:1851-8. 2007
    ....
  27. ncbi request reprint Monitoring of the JAK2-V617F mutation by highly sensitive quantitative real-time PCR after allogeneic stem cell transplantation in patients with myelofibrosis
    Nicolaus Kroger
    Bone Marrow Transplantation, University Medical Center Hamburg Eppendorf, and Department of Hematology Oncology, University Hospital Regensburg, Germany
    Blood 109:1316-21. 2007
    ....
  28. ncbi request reprint Randomized trial of single compared with tandem high-dose chemotherapy followed by autologous stem-cell transplantation in patients with chemotherapy-sensitive metastatic breast cancer
    Nicolaus Kroger
    Bone Marrow Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Clin Oncol 24:3919-26. 2006
    ..To compare progression-free survival between single and tandem high-dose chemotherapy (HDT) followed by autologous stem-cell transplantation in chemotherapy-sensitive metastatic breast cancer patients...
  29. ncbi request reprint Bortezomib after dose-reduced allogeneic stem cell transplantation for multiple myeloma to enhance or maintain remission status
    Nicolaus Kroger
    Department of Bone Marrow Transplantation, Transplant Center, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Exp Hematol 34:770-5. 2006
    ..3 mg/m(2) intravenously, days 1, 4, 8, and 11) after dose-reduced allogeneic stem cell transplantation (SCT) on toxicity, CD3(+) cells, graft-versus-host disease (GvHD), and response in patients with multiple myeloma...
  30. ncbi request reprint Kinetics of plasma-cell chimerism after allogeneic stem cell transplantation by highly sensitive real-time PCR based on sequence polymorphism and its value to quantify minimal residual disease in patients with multiple myeloma
    Nicolaus Kroger
    Department of Bone Marrow Transplantation, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Exp Hematol 34:688-94. 2006
    ....
  31. doi request reprint Allogeneic stem cell transplantation after reduced-intensity conditioning in patients with myelofibrosis: a prospective, multicenter study of the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation
    Nicolaus Kroger
    Center for Stem Cell Transplantation, University Hospital Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Blood 114:5264-70. 2009
    ..70; P = .02) and human leukocyte antigen-mismatched donor (hazard ratio = 3.04; P = .006) remained significant factors for survival. The study was registered at www.clinicaltrials.gov as #NCT 00599547...
  32. ncbi request reprint Prognostic and predictive effects of immunohistochemical factors in high-risk primary breast cancer patients
    Nicolaus Kroger
    Department of Bone Marrow Transplantation, Transplant Center, Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 12:159-68. 2006
    ..To analyze prognostic and predictive effects of immunohistochemical factors within a randomized study of high-dose versus standard-dose chemotherapy in high-risk breast cancer with >10 involved lymph nodes...
  33. ncbi request reprint Deletion of chromosome band 13q14 as detected by fluorescence in situ hybridization is a prognostic factor in patients with multiple myeloma who are receiving allogeneic dose-reduced stem cell transplantation
    Nicolaus Kroger
    Department of Bone Marrow Transplantation, University Hospital Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Blood 103:4056-61. 2004
    ..48; 95% CI, 1.19-5.17; P =.02), while patients with deletion 13q had a nearly 2 times higher risk of death (HR, 1.94; 95% CI, 0.95-3.98; P =.07) after dose-reduced allogeneic stem cell transplantation...
  34. ncbi request reprint Kinetics of G-CSF and CD34+ cell mobilization after once or twice daily stimulation with rHu granulocyte-stimulating factor (lenograstim) in healthy volunteers: an intraindividual crossover study
    Nicolaus Kroger
    Department of Bone Marrow Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Transfusion 44:104-10. 2004
    ..G-CSF given as split dose increased the harvested number of CD34+ cells in comparison to a once daily schedule, but the mechanism is poorly understood...
  35. ncbi request reprint Reduced-toxicity conditioning with treosulfan, fludarabine and ATG as preparative regimen for allogeneic stem cell transplantation (alloSCT) in elderly patients with secondary acute myeloid leukemia (sAML) or myelodysplastic syndrome (MDS)
    N Kroger
    Department of Bone Marrow Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Bone Marrow Transplant 37:339-44. 2006
    ..02). The treatment-related mortality at day 100 was 28%. The 2-year estimated overall and disease-free survival was 36-34%, respectively. No difference in survival was seen between unrelated and related SCT...
  36. ncbi request reprint Anti-thymocyte-globulin as part of the preparative regimen prevents graft failure and severe graft versus host disease (GvHD) in allogeneic stem cell transplantation from unrelated donors
    N Kroger
    Department of Bone Marrow Transplantation, University Hospital Hamburg Eppendorf, Germany
    Ann Hematol 80:209-15. 2001
    ..ATG in unrelated stem cell transplantation reduces the risk of severe acute and chronic GvHD and of graft failure without an obvious increase of severe infection. Further follow-up is mandatory to determine the incidence of late relapse...
  37. ncbi request reprint Long-term follow-up of an intensified myeloablative conditioning regimen with in vivo T cell depletion followed by allografting in patients with advanced multiple myeloma
    Nicolaus Kroger
    Department of Stem Cell Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Biol Blood Marrow Transplant 16:861-4. 2010
    ..Our data indicate that an intensified myeloablative conditioning regimen followed by allogeneic SCT can produce long-term survival and freedom from disease in patients with multiple myeloma who achieve CR...
  38. ncbi request reprint Allogeneic stem cell transplantation of adult chronic myelomonocytic leukaemia. A report on behalf of the Chronic Leukaemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT)
    Nicolaus Kroger
    University Hospital Hamburg, Germany
    Br J Haematol 118:67-73. 2002
    ..The data showed a trend for a lower relapse probability of acute GvHD grade II-IV (24% vs 54%; P = 0.07), and for a higher relapse rate in patients with T cell-depleted grafts (62% vs 45%), suggesting a 'graft-versus-CMML effect'...
  39. ncbi request reprint Donor lymphocyte infusion enhances remission status in patients with persistent disease after allografting for multiple myeloma
    N Kroger
    Bone Marrow Transplantation and Department of Clinical Chemistry, University Hospital Hamburg Eppendorf, and A K St Georg, Hamburg, Germany
    Br J Haematol 112:421-3. 2001
    ..host disease (GvHD) and limited or extensive chronic GvHD in each patient. We conclude that DLI induced further tumour reduction in patients with persistent disease after allografting for multiple myeloma...
  40. ncbi request reprint Autologous stem cell transplantation followed by a dose-reduced allograft induces high complete remission rate in multiple myeloma
    Nicolaus Kroger
    Bone Marrow Transplantation, University Hospital Hamburg, Hamburg, Germany
    Blood 100:755-60. 2002
    ..The tandem auto-allotransplant protocol is highly active and provides rapid engraftment with complete donor chimerism and tolerable toxicity...
  41. ncbi request reprint A randomized comparison of once versus twice daily recombinant human granulocyte colony-stimulating factor (filgrastim) for stem cell mobilization in healthy donors for allogeneic transplantation
    N Kroger
    Department of Bone Marrow Transplantation, University of Hamburg, Germany
    Br J Haematol 111:761-5. 2000
    ....
  42. ncbi request reprint Unrelated stem cell transplantation in multiple myeloma after a reduced-intensity conditioning with pretransplantation antithymocyte globulin is highly effective with low transplantation-related mortality
    Nicolaus Kroger
    Department of Bone Marrow Transplantation, University Hospital Hamburg Eppendorf, Germany
    Blood 100:3919-24. 2002
    ....
  43. ncbi request reprint Long-term follow-up of allogeneic stem cell transplantation in patients with severe aplastic anemia after conditioning with cyclophosphamide plus antithymocyte globulin
    N Kroger
    Department of Bone Marrow Transplantation, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Ann Hematol 81:627-31. 2002
    ..We conclude that ATG plus cyclophosphamide is an effective conditioning regimen in patients with aplastic anemia undergoing stem cell transplantation with a low treatment-related mortality, resulting in an excellent outcome...
  44. doi request reprint Approaches to relapse after allogeneic stem cell transplantation
    Nicolaus Kroger
    Clinic for Stem Cell Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Curr Opin Oncol 23:203-8. 2011
    ..In general, prognosis is poor for patients who relapsed to an allograft since effective treatment options are limited. Here, we review the available and upcoming treatment approaches for relapse...
  45. ncbi request reprint Low incidence of secondary myelodysplasia and acute myeloid leukemia after high-dose chemotherapy as adjuvant therapy for breast cancer patients: a study by the Solid Tumors Working Party of the European Group for Blood and Marrow Transplantation
    N Kroger
    Department of Bone Marrow Transplantation, University Hospital Hamburg, Germany
    Ann Oncol 14:554-8. 2003
    ..To determine the incidence of secondary myelodysplasia (sMDS) or acute myeloid leukemia (AML) in node-positive breast cancer patients who received high-dose chemotherapy (HDCT) followed by autologous stem-cell support as adjuvant therapy...
  46. ncbi request reprint Patient cytomegalovirus seropositivity with or without reactivation is the most important prognostic factor for survival and treatment-related mortality in stem cell transplantation from unrelated donors using pretransplant in vivo T-cell depletion with a
    N Kroger
    Bone Marrow Transplantation, University Hospital Hamburg, Department of Bone Marrow Transplantation, Pavlow University, St Petersburg, Russia
    Br J Haematol 113:1060-71. 2001
    ....
  47. ncbi request reprint Dose and schedule effect of G-GSF for stem cell mobilization in healthy donors for allogeneic transplantation
    Nicolaus Kroger
    Department of Bone Marrow Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Leuk Lymphoma 43:1391-4. 2002
    ..A prolonged follow-up of the donors is needed to rule out late toxicity of the donors...
  48. ncbi request reprint Allogeneic stem cell transplantation after a fludarabine/busulfan-based reduced-intensity conditioning in patients with myelodysplastic syndrome or secondary acute myeloid leukemia
    N Kroger
    Bone Marrow Transplantation, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
    Ann Hematol 82:336-42. 2003
    ....
  49. ncbi request reprint Myeloablative intensified conditioning regimen with in vivo T-cell depletion (ATG) followed by allografting in patients with advanced multiple myeloma. A phase I/II study of the German Study-group Multiple Myeloma (DSMM)
    Nicolaus Kroger
    Bone Marrow Transplantation, University Hospital Hamburg Eppendorf, Germany
    Bone Marrow Transplant 31:973-9. 2003
    ..In vivo T-cell depletion with ATG resulted in a low rate of severe GvHD with low treatment-related mortality, and a substantial number of long-term survivors...
  50. doi request reprint Anti-thymocyte globulin overcomes the negative impact of HLA mismatching in transplantation from unrelated donors
    Francis Ayuk
    Department of Stem Cell Transplantation, University Medical Center Hamburg, Hamburg, Germany
    Exp Hematol 36:1047-54. 2008
    ..Allogeneic HSCT from matched unrelated and mismatched donors carries an increased risk of graft-vs-host disease (GVHD) and transplant-related mortality (TRM)...
  51. doi request reprint Postallograft lenalidomide induces strong NK cell-mediated antimyeloma activity and risk for T cell-mediated GvHD: Results from a phase I/II dose-finding study
    Christine Wolschke
    Clinic for Stem Cell Transplantation, University Medical Center Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
    Exp Hematol 41:134-142.e3. 2013
    ..Study registered under: NCT 00778752.)...
  52. ncbi request reprint Post-transplant immune reconstitution after unrelated allogeneic stem cell transplant in patients with acute myeloid leukemia
    Evgeny Klyuchnikov
    Clinic for Stem Cell Transplantation, University Cancer Center Hamburg, Germany
    Leuk Lymphoma 51:1450-63. 2010
    ..Thus, the evaluation of post-transplant immune reconstitution in patients with AML might improve risk stratification concerning either relapse or TRM and remains to be further explored...
  53. doi request reprint Second allogeneic stem cell transplantation in myeloid malignancies
    Maite Hartwig
    Clinic for Stem Cell Transplantation, University Cancer Center Hamburg, Hamburg, Germany
    Acta Haematol 122:185-92. 2009
    ..Efforts should concentrate on an optimization of conditioning strategies, immunosuppression and post-transplant surveillance for this specific situation...
  54. ncbi request reprint Rapid regression of bone marrow fibrosis after dose-reduced allogeneic stem cell transplantation in patients with primary myelofibrosis
    Nicolaus Kroger
    Department of Stem Cell Transplantation, University Hospital Hamburg, Germany
    Exp Hematol 35:1719-22. 2007
    ..To investigate the effect of a busulfan/fludarabine-based reduced intensity conditioning followed by allogeneic stem cell transplantation on regression of bone marrow fibrosis in patients with myelofibrosis...
  55. pmc Longitudinal analysis of tetanus- and influenza-specific IgG antibodies in myeloma patients
    Sebastian Kobold
    Department of Internal Medicine II, and Department of Oncology, Hematology, Bone Marrow Transplantation Section of Pneumology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany
    Clin Dev Immunol 2012:134081. 2012
    ..We have performed a longitudinal analysis of IgG-antibody responses against influenza virus (FLU) and tetanus toxoid (TT) as surrogate markers for the B cell-mediated immunity in MM patients...
  56. doi request reprint Comparison of two doses of antithymocyte globulin in patients undergoing matched unrelated donor allogeneic stem cell transplantation
    Francis Ayuk
    Department of Stem Cell Transplantation, University Medical Center Hamburg, Hamburg, Germany
    Biol Blood Marrow Transplant 14:913-9. 2008
    ..A prospective randomized study comparing these 2 doses of ATG-F is warranted...
  57. doi request reprint Role of interleukin 16 in multiple myeloma
    Djordje Atanackovic
    Department of Medicine II, Oncology Hematology Stem Cell Transplantation, University Cancer Center Hamburg Hubertus Wald Tumorzentrum, University Medical Center Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
    J Natl Cancer Inst 104:1005-20. 2012
    ..Interleukin 16 (IL-16) is involved in regulating the migration and proliferation of normal leukocytes. However, the role of IL-16 in human cancers, including multiple myeloma, is unclear...
  58. ncbi request reprint CD4+CD25+FOXP3+ T regulatory cells reconstitute and accumulate in the bone marrow of patients with multiple myeloma following allogeneic stem cell transplantation
    Djordje Atanackovic
    Department of Medicine II, Oncology Hematology, University Medical Center, Hamburg Eppendorf Martinistr 52, 20246 Hamburg, Germany
    Haematologica 93:423-30. 2008
    ....
  59. ncbi request reprint Serum albumin level predicts survival of patients with gastrointestinal acute graft-versus-host disease after allogeneic stem cell transplantation
    Francis Ayuk
    Clinic for Stem Cell Transplantation, University Medical Center Hamburg Eppendorf, Martinistr 52, 20245, Hamburg, Germany
    Ann Hematol 93:855-61. 2014
    ..Low serum albumin levels are associated with poorer OS in patients with gut but not skin aGVHD after RIC but not MAC allogeneic stem cell transplantation. ..
  60. doi request reprint Comparative diagnostic performance of ¹⁸F-FDG PET/CT versus whole-body MRI for determination of remission status in multiple myeloma after stem cell transplantation
    Thorsten Derlin
    Department of Diagnostic and Interventional Radiology, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    Eur Radiol 23:570-8. 2013
    ....
  61. doi request reprint Donor lymphocyte infusions and second transplantation as salvage treatment for relapsed myelofibrosis after reduced-intensity allografting
    Evgeny Klyuchnikov
    Department of Stem Cell Transplantation, University Cancer Centre Hamburg, Hamburg, Germany
    Br J Haematol 159:172-81. 2012
    ....
  62. ncbi request reprint Chimerism studies with quantitative real-time PCR in stem cell recipients with acute myeloid leukemia
    Bettina Wiedemann
    Interdisciplinary Clinic for Stem Cell Transplantation, University of Hamburg, Martinistrasse 52, Hamburg, Germany
    Exp Hematol 38:1261-71. 2010
    ..Chimerism is well-established for surveillance of acute myeloid leukemia (AML) patients after allogeneic hematopoietic stem cell transplantation (HSCT), but interpretation of the results and techniques is not standardized...
  63. ncbi request reprint A fludarabine-based dose-reduced conditioning regimen followed by allogeneic stem cell transplantation from related or unrelated donors in patients with myelodysplastic syndrome
    N Kroger
    Bone Marrow Transplantation, University Hospital Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Bone Marrow Transplant 28:643-7. 2001
    ....
  64. ncbi request reprint NCI First International Workshop on the Biology, Prevention, and Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation: report from the Committee on Disease-Specific Methods and Strategies for Monitoring Relapse following Allogenei
    Nicolaus Kroger
    Department for Stem Cell Transplantation, University Medical Center Hamburg Eppendorf, Martinstrasse 52, Hamburg, Germany
    Biol Blood Marrow Transplant 16:1187-211. 2010
    ....
  65. ncbi request reprint Autologous stem cell transplantation in myelodysplastic syndromes
    Theo de Witte
    Department of Hematology, Radboud University Medical Centre Nijmegen, Nijmegen, The Netherlands, and Bone Marrow Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Semin Hematol 44:274-7. 2007
    ..Further development of precise prognostic classification systems, including an accurate evaluation of cytogenetic/molecular response to chemotherapy, is needed to develop a risk-adapted strategy for individual patients...
  66. doi request reprint Pegfilgrastim compared to lenograstim after allogeneic peripheral blood stem-cell transplantation from unrelated donors
    Sunday Ocheni
    Department for Stem Cell Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Leuk Lymphoma 50:612-8. 2009
    ..We conclude that Pegfilgrastim ensured rapid neutrophil engraftment after unrelated allogeneic peripheral SCT, which was at least as effective as daily lenograstim...
  67. doi request reprint The cytokine/chemokine pattern in the bone marrow environment of multiple myeloma patients
    Yanran Cao
    Department of Internal Medicine II Oncology Hematology Stem Cell Transplantation, University Cancer Center Hamburg Hubertus Wald Tumorzentrum, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Exp Hematol 38:860-7. 2010
    ..We aimed at answering the question which cytokines, chemokines, and growth factors are typically found in the BM of untreated MM patients as well as in MM patients after allogeneic stem cell transplantation (alloSCT)...
  68. doi request reprint Quantitative monitoring of NPM1 mutations provides a valid minimal residual disease parameter following allogeneic stem cell transplantation
    Ulrike Bacher
    Clinic for Stem Cell Transplantation, University of Hamburg, Germany
    Exp Hematol 37:135-42. 2009
    ..Nucleophosmin (NPM1) mutations, with their high frequency in AML, were suggested to represent suitable MRD markers, but so far no study has evaluated their usefulness in the posttransplantation period...
  69. pmc Surface molecule CD229 as a novel target for the diagnosis and treatment of multiple myeloma
    Djordje Atanackovic
    Center of Oncology, Department of Medicine II, Oncology Hematology Stem Cell Transplantation, University Cancer Center Hamburg Hubertus Wald Tumorzentrum, Hamburg, Germany
    Haematologica 96:1512-20. 2011
    ..We, therefore, investigated functionally relevant immunoreceptors specifically associated with myeloma cells as well as their clonogenic precursors...
  70. doi request reprint Impact of JAK2V617F mutation status, allele burden, and clearance after allogeneic stem cell transplantation for myelofibrosis
    Haefaa Alchalby
    Department of Stem Cell Transplantation, University Medical Center Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
    Blood 116:3572-81. 2010
    ..03). We conclude that JAK2V617F-mutated status, but not allele frequency, resulted in an improved survival and rapid clearance after allografting reduces the risk of relapse...
  71. doi request reprint Minimal residual disease diagnostics in patients with acute myeloid leukemia in the post-transplant period: comparison of peripheral blood and bone marrow analysis
    Tanja Stahl
    Clinic for Stem Cell Transplantation, University Cancer Center Hamburg, Germany
    Leuk Lymphoma 51:1837-43. 2010
    ....
  72. ncbi request reprint An optimized assay for the enumeration of antigen-specific memory B cells in different compartments of the human body
    Yanran Cao
    Department of Internal Medicine II Oncology, Haematology, Stem Cell Transplantation, University Cancer Centre Hamburg Hubertus Wald Tumorzentrum, Hamburg, Germany
    J Immunol Methods 358:56-65. 2010
    ..In the framework of our current study we set out to develop an optimized assay for the quantification of antigen-specific B cells in different compartments of the human body...
  73. ncbi request reprint Influence of anti-thymocyte globulin as part of the conditioning regimen on immune reconstitution following matched related bone marrow transplantation
    Natalja Fehse
    Bone Marrow Transplantation, University Hospital Eppendorf, Hamburg, Germany
    J Hematother Stem Cell Res 12:237-42. 2003
    ..We observed impaired immune reconstitution in the ATG group in comparison with the non-ATG group, indicating a significant influence of ATG on immune recovery for several months after BMT...
  74. ncbi request reprint Secondary acute leukemia following mitoxantrone-based high-dose chemotherapy for primary breast cancer patients
    N Kroger
    Department of Bone Marrow Transplantation, University of Hamburg, Hamburg, Germany
    Bone Marrow Transplant 32:1153-7. 2003
    ..She achieved CR after induction therapy, but relapsed and expired 28 months after diagnosis of AML. sAML after mitoxantrone-based HDCT is a possible, but rare complication in breast cancer patients...
  75. doi request reprint Longitudinal analysis and prognostic effect of cancer-testis antigen expression in multiple myeloma
    Djordje Atanackovic
    Department of Oncology Hematology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 15:1343-52. 2009
    ....
  76. doi request reprint Purification of CD4+ T cells for adoptive immunotherapy after allogeneic hematopoietic stem cell transplantation
    Evgeny Klyuchnikov
    Department of Stem Cell Transplantation, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Biol Blood Marrow Transplant 17:374-83. 2011
    ..Automated enrichment of CD4(+) by magnetic cell sorting provides an efficient and rapid method for processing donor lymphocytes. Additional studies should further investigate this approach in terms of efficacy and the risk of GVHD...
  77. ncbi request reprint Cancer-testis antigens are commonly expressed in multiple myeloma and induce systemic immunity following allogeneic stem cell transplantation
    Djordje Atanackovic
    Department of Oncology Hematology, Institute for Biochemistry and Molecular Biology, University Medical Center Hamburg Eppendorf, Germany
    Blood 109:1103-12. 2007
    ..Immune responses induced by alloSCT could be boosted by active CT antigen-specific immunotherapy, which might help to achieve long-lasting remissions in patients with MM...
  78. ncbi request reprint Diagnosis of Toxoplasma gondii infection after allogeneic stem cell transplant can be difficult and requires intensive scrutiny
    Irene Cavattoni
    Interdisciplinary Clinic for Stem Cell Transplantation, University of Hamburg, Germany
    Leuk Lymphoma 51:1530-5. 2010
    ..Post-transplant prevention strategies and treatment to control advanced infection in this setting are discussed...
  79. ncbi request reprint Expression and prognostic relevance of MAGE-C1/CT7 and MAGE-C2/CT10 in osteolytic lesions of patients with multiple myeloma
    Caroline Pabst
    Department of Oncology Hematology Bone Marrow Transplantation with the Section Pneumology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Exp Mol Pathol 89:175-81. 2010
    ..013). Our results, therefore, suggest that expression of MAGE-C1/CT7 and MAGE-C2/CT10 in osteolytic lesions of myeloma patients can be used for diagnostic, prognostic, as well as immunotherapeutic purposes...
  80. ncbi request reprint Impact of genetic abnormalities on survival after allogeneic hematopoietic stem cell transplantation in multiple myeloma
    G Schilling
    Department of Oncology and Hematology, Medical Clinic II, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Leukemia 22:1250-5. 2008
    ..Translocation t(4;14) might be overcome by allogeneic HSCT, which will have implication for risk-adapted strategies...
  81. ncbi request reprint Comparison of total body irradiation vs busulfan in combination with cyclophosphamide as conditioning for unrelated stem cell transplantation in CML patients
    N Kroger
    Bone Marrow Transplantation, University Hospital Hamburg, Germany
    Bone Marrow Transplant 27:349-54. 2001
    ..Longer follow-up is necessary to determine the late relapse rate and late toxicity...
  82. doi request reprint Expression, epigenetic regulation, and humoral immunogenicity of cancer-testis antigens in chronic myeloid leukemia
    Tim Luetkens
    Department of Oncology and Hematology, Center of Oncology, Hamburg, Germany
    Leuk Res 34:1647-55. 2010
    ..However, a broad picture of the expression of CT antigens and associated humoral immune responses in chronic myeloid leukemia (CML) is still missing...
  83. ncbi request reprint Diagnostic tools in the indications for allogeneic stem cell transplantation in myelodysplastic syndromes
    Ulrike Bacher
    Interdisciplinary Clinic for Stem Cell Transplantation, University Cancer Center Hamburg, Hamburg, Germany
    Biol Blood Marrow Transplant 16:1-11. 2010
    ..Consequently, in the near future, risk stratification in MDS might incorporate additional diagnostic tools and categorization systems aimed at improving the timing and indication for SCT in this complex disorder...
  84. ncbi request reprint Comparison of the cytotoxicity of 4 preparations of anti-T-cell globulins in various hematological malignancies
    Francis Ayuk
    Department of Bone Marrow Transplantation, University Medical Center Hamburg Eppendorf, D 20246 Hamburg, Germany
    Anticancer Res 29:1355-60. 2009
    ..The cytotoxic effects of 4 ATG preparations (Thymoglobulin, ATG-Fresenius, Lymphoglobulin and ATGAM) in hematological malignancies were compared...
  85. ncbi request reprint Antithymocyte globulin induces complement-dependent cell lysis and caspase-dependent apoptosis in myeloma cells
    Francis A Ayuk
    Department of Bone Marrow Transplantation, University Medical Center Hamburg Eppendorf, Germany
    Exp Hematol 33:1531-6. 2005
    ..Because both agents have been reported to induce depletion of B cells, we sought to investigate their cytotoxic activity on myeloma cells...
  86. ncbi request reprint Comparable results in patients with acute lymphoblastic leukemia after related and unrelated stem cell transplantation
    J Dahlke
    Department of Bone Marrow Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Bone Marrow Transplant 37:155-63. 2006
    ..56, 95% CI: 0.33-0.98, P=0.042), negative CMV status of the patient (RR: 0.57, 95% CI: 0.36-0.90, P = 0.015). Unrelated stem cell transplantation for high-risk ALL patients with no HLA-compatible family donor is justifiable...
  87. ncbi request reprint ATG as part of the conditioning regimen reduces transplant-related mortality (TRM) and improves overall survival after unrelated stem cell transplantation in patients with chronic myelogenous leukemia (CML)
    A R Zander
    Department of Bone Marrow Transplantation, University Hospital Hamburg Eppendorf, Germany
    Bone Marrow Transplant 32:355-61. 2003
    ..01 and P=0.03) and led to a significant better overall survival (70 vs 57%, P=0.03). We concluded that a prospective randomized study is needed to evaluate the definite role of ATG in hemopoietic stem cell transplantation...
  88. ncbi request reprint Allogeneic stem-cell transplantation in patients with refractory acute leukemia: a long-term follow-up
    A A Oyekunle
    Department of Bone Marrow Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Bone Marrow Transplant 37:45-50. 2006
    ..We conclude that patients with refractory leukemia can benefit from allogeneic BMT, especially with < or =20% marrow blast...
  89. ncbi request reprint Randomized trial of high-dose adjuvant chemotherapy with autologous hematopoietic stem-cell support versus standard-dose chemotherapy in breast cancer patients with 10 or more positive lymph nodes: overall survival after 6 years of follow-up
    A R Zander
    Center of Oncology, Clinic for Stem Cell Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Ann Oncol 19:1082-9. 2008
    ..With a follow-up of 6 years, there was a trend in favor of HD-CT with respect to EFS not being significant. A proper meta-analysis needs to be undertaken for an evaluation of subgroups of patients who might benefit from HD-CT...
  90. ncbi request reprint Disseminated breast cancer cells prior to and after high-dose therapy
    W H Krüger
    Bone Marrow Transplantation Centre, University Hospital Eppendorf, Hamburg, Germany
    J Hematother Stem Cell Res 10:681-9. 2001
    ..However, further research is necessary to identify distinct cell populations with the potentially capacity to metastasize...
  91. pmc Specificity of reverse transcriptase polymerase chain reaction assays designed for the detection of circulating cancer cells is influenced by cytokines in vivo and in vitro
    R Jung
    Department of Clinical Chemistry, University Hospital Eppendorf, Hamburg, Germany
    Br J Cancer 78:1194-8. 1998
    ..These factors have to be considered in future applications of RT-PCR for the detection of minimal residual disease...
  92. ncbi request reprint In vivo T cell depletion with pretransplant anti-thymocyte globulin reduces graft-versus-host disease without increasing relapse in good risk myeloid leukemia patients after stem cell transplantation from matched related donors
    N Kroger
    Bone Marrow Transplantation, University Hospital, Hamburg Eppendorf, Martinistrasse 52, D 20246, Hamburg, Germany
    Bone Marrow Transplant 29:683-9. 2002
    ..ATG as part of the conditioning regimen leads to a significant reduction in GVHD without increase of relapse in patients with myeloid leukemia after stem cell transplantation from HLA-related donors...
  93. ncbi request reprint Complement-dependent and complement-independent cytotoxicity of polyclonal antithymocyte globulins in chronic lymphocytic leukemia
    Francis A Ayuk
    Department of Bone Marrow Transplantation, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Leuk Res 32:1200-6. 2008
    ..ATGs however, contain antibodies targeting antigens expressed on various hematopoietic cells including B cells...
  94. doi request reprint Cancer-testis antigen expression and its epigenetic modulation in acute myeloid leukemia
    Djordje Atanackovic
    Center of Oncology, Department of Internal Medicine II, Oncology Hematology Stem Cell Transplantation, University Cancer Center Hamburg, Germany
    Am J Hematol 86:918-22. 2011
    ..Therefore, we propose that CTA-specific immunotherapy for AML should preferentially target PRAME and/or should be combined with the application of demethylating agents opening the perspective for alternative targets like CTA SSX-2...
  95. ncbi request reprint High-dose therapy for breast cancer - a case of suspended animation
    Axel R Zander
    University Hospital Hamburg Eppendorf, Hamburg Eppendorf, Germany
    Acta Haematol 114:248-54. 2005
    ..It is further necessary to look at the biology of breast cancer in the context of high-dose chemotherapy studies...
  96. pmc Cancer-testis antigens MAGE-C1/CT7 and MAGE-A3 promote the survival of multiple myeloma cells
    Djordje Atanackovic
    Department of Medicine II, Oncology Hematology, University Medical Center, Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
    Haematologica 95:785-93. 2010
    ..Surprisingly, the biological role of cancer-testis genes in myeloma remains poorly understood...
  97. doi request reprint Antitumor effects of polyclonal antithymocyte globulins: focus on B-cell malignancies and multiple myeloma
    Francis Ayuk
    University Medical Center Hamburg Eppendorf, Germany
    Ann Hematol 88:401-4. 2009
    ..This review discusses available data demonstrating the cytotoxic effects of ATGs and envisages a possible new role of these polyclonal antibodies in the therapy of hematological malignancies...
  98. doi request reprint Characterisation of extramedullary relapse in patients with chronic myeloid leukemia in advanced disease after allogeneic stem cell transplantation
    Sunday Ocheni
    Clinic for Stem Cell Transplantation, University Cancer Centre Hamburg, Hamburg, Germany
    Leuk Lymphoma 50:551-8. 2009
    ..Research should focus on prospective studies aiming to improve treatment of extramedullary relapse in stem cell recipients with CML with a special focus on the role of second generation tyrosine kinase inhibitors...
  99. pmc Detection of virulence-associated genes not useful for discriminating between invasive and commensal Staphylococcus epidermidis strains from a bone marrow transplant unit
    Holger Rohde
    Institut für Infektionsmedizin, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    J Clin Microbiol 42:5614-9. 2004
    ..epidermidis strains. The dynamics of S. epidermidis populations reveal that detection of icaADBC and mecA is not suitable for discriminating invasive from contaminating S. epidermidis strains...