Antje Körner

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. pmc The LIFE child study: a life course approach to disease and health
    Mirja Quante
    LIFE Leipzig Research Centre for Civilization Diseases, University of Leipzig, Philipp Rosenthalstrasse 27, D 04103 Leipzig, Germany
    BMC Public Health 12:1021. 2012
  2. doi request reprint Longitudinal multicenter analysis on the course of glucose metabolism in obese children
    A Korner
    Center for Pediatric Research, Department of Women and Child Health, University Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany
    Int J Obes (Lond) 37:931-6. 2013
  3. pmc Leucocytes are a major source of circulating nicotinamide phosphoribosyltransferase (NAMPT)/pre-B cell colony (PBEF)/visfatin linking obesity and inflammation in humans
    D Friebe
    University Hospital for Children and Adolescents, University of Leipzig, Liebigstr 20a, 04103 Leipzig, Germany
    Diabetologia 54:1200-11. 2011
  4. ncbi request reprint TCF7L2 gene polymorphisms confer an increased risk for early impairment of glucose metabolism and increased height in obese children
    Antje Körner
    University Hospital for Children and Adolescents, University of Leipzig, Oststrasse 21 25, 04317 Leipzig, Germany
    J Clin Endocrinol Metab 92:1956-60. 2007
  5. ncbi request reprint New predictors of the metabolic syndrome in children--role of adipocytokines
    Antje Körner
    University Hospital for Children and Adolescents, University of Leipzig, 04317 Leipzig, Germany
    Pediatr Res 61:640-5. 2007
  6. ncbi request reprint Molecular characteristics of serum visfatin and differential detection by immunoassays
    Antje Körner
    Research Laboratory, University Hospital for Children and Adolescents, University of Leipzig, Liebigstrasse 20a, 04103 Leipzig, Germany
    J Clin Endocrinol Metab 92:4783-91. 2007
  7. doi request reprint Polygenic contribution to obesity: genome-wide strategies reveal new targets
    Antje Körner
    University Hospital for Children and Adolescents, Research Laboratory, University of Leipzig, Leipzig, Germany
    Front Horm Res 36:12-36. 2008
  8. doi request reprint Chemerin as a mediator between obesity and vascular inflammation in children
    Kathrin Landgraf
    Pediatric Research Center, Department of Women s and Child Health, University of Leipzig, Liebigstrasse 20a, 04103 Leipzig, Germany
    J Clin Endocrinol Metab 97:E556-64. 2012
  9. pmc Genetic and evolutionary analyses of the human bone morphogenetic protein receptor 2 (BMPR2) in the pathophysiology of obesity
    Dorit Schleinitz
    Interdisciplinary Center for Clinical Research, University of Leipzig, Leipzig, Germany
    PLoS ONE 6:e16155. 2011
  10. ncbi request reprint Obesity in childhood and adolescence: a review in the interface between adipocyte physiology and clinical challenges
    Antje Körner
    Hospital for Children and Adolescents, University of Leipzig, Oststr 21 25, D 04317 Leipzig, Germany
    Hormones (Athens) 4:189-199. 2005

Collaborators

Detail Information

Publications33

  1. pmc The LIFE child study: a life course approach to disease and health
    Mirja Quante
    LIFE Leipzig Research Centre for Civilization Diseases, University of Leipzig, Philipp Rosenthalstrasse 27, D 04103 Leipzig, Germany
    BMC Public Health 12:1021. 2012
    ..Epidemiological studies together with new powerful research technologies present exciting opportunities to the elucidation of risk factor-outcome associations with potentially major consequences for prevention, diagnosis and treatment...
  2. doi request reprint Longitudinal multicenter analysis on the course of glucose metabolism in obese children
    A Korner
    Center for Pediatric Research, Department of Women and Child Health, University Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany
    Int J Obes (Lond) 37:931-6. 2013
    ..We aimed to assess the prevalence and the longitudinal course of impaired glucose metabolism assessed by oral glucose tolerance test (oGTT) in a large multi-center pediatric obesity registry...
  3. pmc Leucocytes are a major source of circulating nicotinamide phosphoribosyltransferase (NAMPT)/pre-B cell colony (PBEF)/visfatin linking obesity and inflammation in humans
    D Friebe
    University Hospital for Children and Adolescents, University of Leipzig, Liebigstr 20a, 04103 Leipzig, Germany
    Diabetologia 54:1200-11. 2011
    ..We systematically studied the association between circulating NAMPT, obesity, interventions and glucose metabolism and investigated potential underlying inflammatory mechanisms...
  4. ncbi request reprint TCF7L2 gene polymorphisms confer an increased risk for early impairment of glucose metabolism and increased height in obese children
    Antje Körner
    University Hospital for Children and Adolescents, University of Leipzig, Oststrasse 21 25, 04317 Leipzig, Germany
    J Clin Endocrinol Metab 92:1956-60. 2007
    ....
  5. ncbi request reprint New predictors of the metabolic syndrome in children--role of adipocytokines
    Antje Körner
    University Hospital for Children and Adolescents, University of Leipzig, 04317 Leipzig, Germany
    Pediatr Res 61:640-5. 2007
    ..Overall factors from the adipose tissue may constitute not only markers but also mediators of metabolic sequelae of obesity...
  6. ncbi request reprint Molecular characteristics of serum visfatin and differential detection by immunoassays
    Antje Körner
    Research Laboratory, University Hospital for Children and Adolescents, University of Leipzig, Liebigstrasse 20a, 04103 Leipzig, Germany
    J Clin Endocrinol Metab 92:4783-91. 2007
    ..We aimed to characterize molecular features of visfatin, to assess visfatin detection by different immunoassays, and evaluate the association with human obesity and glucose metabolism...
  7. doi request reprint Polygenic contribution to obesity: genome-wide strategies reveal new targets
    Antje Körner
    University Hospital for Children and Adolescents, Research Laboratory, University of Leipzig, Leipzig, Germany
    Front Horm Res 36:12-36. 2008
    ..Considering the function of the encoded proteins, it will now be of interest to investigate the cellular and molecular mechanisms, how these genetic variations affect body weight, energy metabolism and/or obesity-associated morbidity...
  8. doi request reprint Chemerin as a mediator between obesity and vascular inflammation in children
    Kathrin Landgraf
    Pediatric Research Center, Department of Women s and Child Health, University of Leipzig, Liebigstrasse 20a, 04103 Leipzig, Germany
    J Clin Endocrinol Metab 97:E556-64. 2012
    ..The chemoattractant protein chemerin has recently been shown to be expressed in adipose tissue...
  9. pmc Genetic and evolutionary analyses of the human bone morphogenetic protein receptor 2 (BMPR2) in the pathophysiology of obesity
    Dorit Schleinitz
    Interdisciplinary Center for Clinical Research, University of Leipzig, Leipzig, Germany
    PLoS ONE 6:e16155. 2011
    ..The BMPR2 locus has been suggested as target of recent selection in human populations. We hypothesized that BMPR2 might have a role in the pathophysiology of obesity...
  10. ncbi request reprint Obesity in childhood and adolescence: a review in the interface between adipocyte physiology and clinical challenges
    Antje Körner
    Hospital for Children and Adolescents, University of Leipzig, Oststr 21 25, D 04317 Leipzig, Germany
    Hormones (Athens) 4:189-199. 2005
    ..Treatment and prevention of obesity in childhood and adolescence are major challenges for today's health care providers and societies...
  11. doi request reprint Effect of increased exercise in school children on physical fitness and endothelial progenitor cells: a prospective randomized trial
    Claudia Walther
    Department of Cardiology, University of Leipzig, Heart Center, 4289 Leipzig, Germany
    Circulation 120:2251-9. 2009
    ....
  12. doi request reprint Effect of genetic variation in the human fatty acid synthase gene (FASN) on obesity and fat depot-specific mRNA expression
    Dorit Schleinitz
    Interdisciplinary Centre for Clinical Research, Leipzig, Germany
    Obesity (Silver Spring) 18:1218-25. 2010
    ..04). No effect of genetic variation in FASN on obesity was found in children. In conclusion, our data indicate a role of FASN genetic variation in susceptibility to obesity in adults...
  13. ncbi request reprint ENPP1 variants and haplotypes predispose to early onset obesity and impaired glucose and insulin metabolism in German obese children
    Yvonne Bottcher
    Medical Department III, University of Leipzig, Philipp Rosenthal Strasse 27, D 04103 Leipzig, Germany
    J Clin Endocrinol Metab 91:4948-52. 2006
    ..Hence, variants in this gene may be related to obesity and insulin resistance...
  14. pmc Effects of genetic variants in ADCY5, GIPR, GCKR and VPS13C on early impairment of glucose and insulin metabolism in children
    Jan Windholz
    University Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany
    PLoS ONE 6:e22101. 2011
    ..We investigated the role of four of these loci (ADCY5, GIPR, GCKR and VPS13C) in early impairment of glucose and insulin metabolism in children...
  15. ncbi request reprint Metabolic syndrome in children and adolescents--risk for sleep-disordered breathing and obstructive sleep-apnoea syndrome?
    Antje Körner
    University Hospital for Children and Adolescents, University of Leipzig, Germany
    Arch Physiol Biochem 114:237-43. 2008
    ..Finally, low-grade systemic inflammation may underlie the clustering of metabolic risk factors. Overall factors from the adipose tissue may constitute not only markers but also mediators of metabolic sequelae of obesity...
  16. ncbi request reprint Adiponectin expression in humans is dependent on differentiation of adipocytes and down-regulated by humoral serum components of high molecular weight
    Antje Körner
    University Hospital for Children and Adolescents, University of Leipzig, Germany
    Biochem Biophys Res Commun 337:540-50. 2005
    ....
  17. ncbi request reprint Effects of genetic variation in the visfatin gene (PBEF1) on obesity, glucose metabolism, and blood pressure in children
    Antje Körner
    University Hospital for Children and Adolescents, University of Leipzig, D 04103 Leipzig, Germany
    Metabolism 56:772-7. 2007
    ..In conclusion, genetic variants in PBEF1 may be associated with increased BP in children but are not likely to contribute significantly to the variation in body mass index and glucose, insulin, or lipid metabolism...
  18. pmc Adipose tissue expression and genetic variants of the bone morphogenetic protein receptor 1A gene (BMPR1A) are associated with human obesity
    Yvonne Bottcher
    Department of Medicine, University of Leipzig, Leipzig, Germany
    Diabetes 58:2119-28. 2009
    ..Members of the family of bone morphogenetic proteins (BMPs) are important regulators of adipogenesis. We examined the role of the BMP receptor 1A gene (BMPR1A) in the pathophysiology of human obesity...
  19. ncbi request reprint Impact of weight status on the onset and parameters of puberty: analysis of three representative cohorts from central Europe
    Sabine Heger
    Hospital for Children and Adolescents, University of Leipzig, Germany
    J Pediatr Endocrinol Metab 21:865-77. 2008
    ..Once girls have reached a critical weight for entering the process of maturation, further increase in body weight does not seem to advance the onset of puberty...
  20. doi request reprint Clinical and functional relevance of melanocortin-4 receptor variants in obese German children
    Christin Melchior
    Molecular Biochemistry, Institute of Biochemistry, University Hospital for Children and Adolescents, Medical Faculty, University of Leipzig, Leipzig, Germany
    Horm Res Paediatr 78:237-46. 2012
    ..Variants in the melanocortin-4 receptor (MC4R) gene are the most frequent cause of monogenic obesity. The relevance of MC4R variations with respect to clinical phenotype and biochemical function remains controversial...
  21. pmc The adipocytokine Nampt and its product NMN have no effect on beta-cell survival but potentiate glucose stimulated insulin secretion
    Robert Spinnler
    Center for Pediatric Research Leipzig CPL, Department for Women and Child Health, University of Leipzig, Leipzig, Germany
    PLoS ONE 8:e54106. 2013
    ....
  22. doi request reprint TCF7L2 gene expression in human visceral and subcutaneous adipose tissue is differentially regulated but not associated with type 2 diabetes mellitus
    Peter Kovacs
    Junior Research Group N06, Interdisciplinary Centre for Clinical Research Leipzig, Faculty of Medicine, University of Leipzig, 04103 Leipzig, Germany
    Metabolism 57:1227-31. 2008
    ..Based on our data, TCF7L2 mRNA expression is fat-depot specific but does not seem to provide the mechanistic link explaining genetic association with T2DM...
  23. doi request reprint Adipocytes and adipose tissue
    Wieland Kiess
    Hospital for Children and Adolescents, University of Leipzig, Liebigstr 20a, D 04103 Leipzig, Germany
    Best Pract Res Clin Endocrinol Metab 22:135-53. 2008
    ..Collectively, the results of the studies cited herein delineate the basis for imprinting or conditioning of fetal pre-adipocytes at the paracrine/autocrine level, and of fetal adipose tissue development and metabolism...
  24. doi request reprint Analysis of a rare functional truncating mutation rs61757459 in vaspin (SERPINA12) on circulating vaspin levels
    Jana Breitfeld
    Department of Medicine, University of Leipzig, Leipzig, Germany
    J Mol Med (Berl) 91:1285-92. 2013
    ..coli and in lysate, but not in supernatant of HEK293 cells. We conclude that rs61757459 is a functional mutation that results in a truncated protein whose instability likely results in reduced serum vaspin levels...
  25. pmc Impact of metabolic regulators on the expression of the obesity associated genes FTO and NAMPT in human preadipocytes and adipocytes
    Daniela Friebe
    University Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany
    PLoS ONE 6:e19526. 2011
    ..In this study, we evaluated the transcriptional regulation of FTO and NAMPT in preadipocytes and adipocytes by metabolic regulators...
  26. doi request reprint Perception of body weight status: a case control study of obese and lean children and adolescents and their parents
    Hagen Rudolph
    University Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany
    Obes Facts 3:83-91. 2010
    ....
  27. doi request reprint Serum concentrations of anti-thyroid peroxidase and anti-thyroglobulin antibodies in children and adolescents without apparent thyroid disorders
    Katharina Taubner
    Hospital for Children and Adolescents, Department for Women and Child Health, University Hospital Leipzig, Centre for Paediatric Research, University of Leipzig, Liebigstraße 20a, D 04103 Leipzig, Germany
    Clin Biochem 47:3-7. 2014
    ..Additionally, we investigated the correlation of TPOAb and TGAb with thyroid parameters as well as with putative confounding parameters such as standard deviation scores (SDS) of height, BMI-SDS and CRP...
  28. pmc TCF7L2 and therapeutic response to sulfonylureas in patients with type 2 diabetes
    Andreas Holstein
    Interdisciplinary Centre for Clinical Research, University of Leipzig, Leipzig, Germany
    BMC Med Genet 12:30. 2011
    ..Since the association with diabetes could be explained by effects on insulin secretion, we investigated whether patients with diabetes risk alleles at rs7903146 might have an altered hypoglycaemic response to sulfonylureas (SUs)...
  29. doi request reprint Heterozygous mutation within a kinase-conserved motif of the insulin-like growth factor I receptor causes intrauterine and postnatal growth retardation
    Tassilo Kruis
    University Hospital for Children and Adolescents, Liebigstrasse 20a, D 04103 Leipzig, Germany
    J Clin Endocrinol Metab 95:1137-42. 2010
    ..Conclusion: The identified G1125A mutation results in a kinase-deficient IGF1R, which is likely to cause the phenotype of intrauterine and postnatal growth retardation...
  30. pmc Nampt: linking NAD biology, metabolism and cancer
    Antje Garten
    University of Leipzig, Hospital for Children and Adolescents, Research Laboratory, Oststr 21 25, 04317 Leipzig, Germany
    Trends Endocrinol Metab 20:130-8. 2009
    ..This review summarizes these various functional aspects of Nampt and discusses its potential roles in diseases, including type 2 diabetes and cancer...
  31. doi request reprint Increasing physical education in high school students: effects on concentration of circulating endothelial progenitor cells
    Claudia Walther
    Department of Cardiology, Heart Center, University of Leipzig, Leipzig, Germany
    Eur J Cardiovasc Prev Rehabil 15:416-22. 2008
    ..In the context of primary prevention, the impact of regular physical activity on the amount and function of EPC has not yet been investigated in school children...
  32. doi request reprint Harmonization of growth hormone measurements with different immunoassays by data adjustment
    Anne Muller
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Leipzig, Germany
    Clin Chem Lab Med 49:1135-42. 2011
    ....
  33. doi request reprint Sirolimus treatment of severe PTEN hamartoma tumor syndrome: case report and in vitro studies
    Gordian L Schmid
    1 Hospital for Children and Adolescents, Department of Women and Child Health, Center for Pediatric Research Leipzig, University of Leipzig, Leipzig, Germany 2 Leipzig University Medical Center, IFB Adiposity Diseases, Leipzig, Germany
    Pediatr Res 75:527-34. 2014
    ..Our in vitro findings point to PI3K and AKT inhibitors as potential treatment options for patients with severe forms of PHTS. ..