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Genomes and Genes | W KrizSummaryAffiliation: University of Heidelberg Country: Germany Publications
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Publications
The podocyte's response to stress: the enigma of foot process effacementWilhelm Kriz
Centre for Biomedicine and Medical Technology Mannheim CBTM Anatomy and Developmental Biology, Medical Faculty Mannheim, Heidelberg Univ, D 68167 Mannheim, Ludolf Krehl Str 13 17, Germany
Am J Physiol Renal Physiol 304:F333-47. 2013..We raise the hypothesis that foot process effacement represents a protective response of podocytes to escape detachment from the GBM...
Adenosine and ATP: traffic regulators in the kidneyWilhelm Kriz
Department of Anatomy and Cell Biology, University of Heidelberg, Heidelberg, Germany
J Clin Invest 114:611-3. 2004..Facing the threat of urinary salt loss, this mechanism causes vasoconstriction and reduces filtration by generating adenosine through the hydrolysis of nucleotide precursors such as 5'-AMP and possibly ATP...
Pathways to nephron loss starting from glomerular diseases-insights from animal modelsWilhelm Kriz
Institute of Anatomy and Cell Biology, University of Heidelberg, Heidelberg, Germany
Kidney Int 67:404-19. 2005..The only option for extracapillary injuries with tuft adhesion is repair by formation of a segmental adherent scar (i.e., segmental glomerulosclerosis)...- Podocyte is the major culprit accounting for the progression of chronic renal diseaseWilhelm Kriz
Institut fur Anatomie und Zellbiologie, Universitat Heidelberg, D 69120 Heidelberg, Germany
Microsc Res Tech 57:189-95. 2002..It appears that the process that leads to the degeneration of a nephron in the context of "classic" FSGS always starts separately in the respective glomerulus by severe podocyte injury... - TRPC6 - a new podocyte gene involved in focal segmental glomerulosclerosisWilhelm Kriz
Institut fur Anatomie und Zellbiologie, Universitat Heidelberg, INF 307, D69120 Heidelberg, Germany
Trends Mol Med 11:527-30. 2005.... - Tracer studies in the rat demonstrate misdirected filtration and peritubular filtrate spreading in nephrons with segmental glomerulosclerosisW Kriz
Institut fur Anatomie und Zellbiologie, Universitat Heidelberg, Heidelberg, Germany
J Am Soc Nephrol 12:496-506. 2001.... - Ontogenetic development of the filtration barrierWilhelm Kriz
Anatomy and Cell Biology, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany
Nephron Exp Nephrol 106:e44-50. 2007..The last step in this development, the formation of the slit membrane, marks a caesura between diseases with early and late onset; all disorders without a properly developed slit membrane start prenatally or at birth... - How does podocyte damage result in tubular damage?W Kriz
Institut fur Anatomie und Zellbiologie, Universitat Heidelberg, Heidelberg, Germany
Kidney Blood Press Res 22:26-36. 1999..Therefore, histopathologically, 'classic' FSGS is best defined by an adhesion/synechia of the tuft to Bowman's capsule... - Pathways to recovery and loss of nephrons in anti-Thy-1 nephritisWilhelm Kriz
Institute of Anatomy and Cell Biology, University of Heidelberg, Im Neuenheimer Feld 307, D 69120 Heidelberg, Germany
J Am Soc Nephrol 14:1904-26. 2003..No evidence emerged to suggest that the kind of focal interstitial proliferation associated with the degeneration of injured nephrons was harmful to a neighboring healthy nephron... - Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?Wilhelm Kriz
Department of Anatomy and Developmental Biology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
J Clin Invest 121:468-74. 2011..Herein, we review and summarize both sides of this debate, but it is our view that unequivocal evidence supporting EMT as an in vivo process in kidney fibrosis is lacking... - Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell linesP Mundel
Department of Anatomy and Cell Biology, University of Heidelberg, Germany
Exp Cell Res 236:248-58. 1997..Therefore, the determinative steps of podocyte differentiation and process formation are studied for the first time using an inducible in vitro model... - Podocyte injury underlies the progression of focal segmental glomerulosclerosis in the fa/fa Zucker ratN Gassler
, , , Heidelberg, Germany
Kidney Int 60:106-16. 2001..Thus, each nephron entering this pathway to degeneration appears to start separately with the same initial injuries at the glomerulus... - Induction of differentiation in cultured rat and human podocytesP Mundel
Department of Anatomy and Cell Biology, University of Heidelberg, Germany
J Am Soc Nephrol 8:697-705. 1997..It was concluded that partial differentiation of cultured podocytes can be achieved simply by avoiding repeated subcultivation, resulting in an arborized phenotype more closely reflecting in vivo podocytes... - Effects of increased renal tubular vascular endothelial growth factor (VEGF) on fibrosis, cyst formation, and glomerular diseaseSamy Hakroush
Centrum für Biomedizin und Medizintechnik Mannheim, University of Heidelberg, Germany
Am J Pathol 175:1883-95. 2009..Systemic VEGF lacks this effect, leading to severe deterioration in glomerular architecture, similar to that seen in diabetic nephropathy... - Expression and signaling of parathyroid hormone-related protein in cultured podocytesN Endlich
Institute of Anatomy and Cell Biology, University of Heidelberg, Germany
Exp Nephrol 9:436-43. 2001..However, PTHrP(1-36) attenuated the bradykinin-induced increase in [Ca2+]i. Our results suggest that PTHrP is an autocrine hormone in podocytes, which selectively activates the cAMP pathway through the PTH/PTHrP receptor... - Progression of glomerular diseases: is the podocyte the culprit?W Kriz
Institut fur Anatomie und Zellbiologie, Universitat Heidelberg, Germany
Kidney Int 54:687-97. 1998..The relevance of such filtration is as yet unclear but may play a considerable role in progression to global sclerosis and interstitial fibrosis... - Update in podocyte biologyK Endlich
Institute for Anatomy and Cell Biology, University of Heidelberg, Heidelberg, Germany
Curr Opin Nephrol Hypertens 10:331-40. 2001..Efforts to understand molecular mechanisms causing these derangements are increasingly successful and will allow a better targeting of interventions to halt the progression of chronic renal disease... 
Synaptopodin: an actin-associated protein in telencephalic dendrites and renal podocytesP Mundel
Department of Anatomy and Cell Biology, University of Heidelberg, Germany
J Cell Biol 139:193-204. 1997....- Podocytes populate cellular crescents in a murine model of inflammatory glomerulonephritisMarcus J Moeller
Division of Nephrology, Department of Internal Medicine, University of Michigan, and Department of Veterans Affairs, Ann Arbor, Michigan, USA
J Am Soc Nephrol 15:61-7. 2004..Podocyte-specific antigens, including WT-1, synaptopodin, nephrin, and podocin, were not expressed by any cells in glomerular crescents, suggesting that podocytes underwent profound phenotypic changes in this nephritis model... - Angiotensin II type 1 receptor overexpression in podocytes induces glomerulosclerosis in transgenic ratsSigrid Hoffmann
Medical Research Center, Faculty for Clinical Medicine Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, Haus 8, Ebene 4, Mannheim 68135, Germany
J Am Soc Nephrol 15:1475-87. 2004..76) and urinary albumin excretion (r(2) = 0.70). The data provide direct evidence that increased AT1 signaling in podocytes leads to protein leakage and structural podocyte damage progressing to focal segmental glomerulosclerosis... - An efficient system for tissue-specific overexpression of transgenes in podocytes in vivoMarcus J Moeller
Institute for Anatomy and Cell Biology, University of Heidelberg, Germany
Am J Physiol Renal Physiol 289:F481-8. 2005..This approach should also circumvent common limitations arising from lethality or transgene silencing as a consequence of transgene overexpression... - The pathogenesis of 'classic' focal segmental glomerulosclerosis-lessons from rat modelsWilhelm Kriz
lnstitut für Anatomie and Zellbiologle, Universitat Heidelberg, Heidelberg, Germany
Nephrol Dial Transplant 18:vi39-44. 2003..There is no nephron-to-nephron transfer of the disease at the level of the tubular interstitium... - Nonuniform microtubular polarity established by CHO1/MKLP1 motor protein is necessary for process formation of podocytesN Kobayashi
Department of Anatomy and Cell Biology, University of Heidelberg, D 69120 Heidelberg, Germany
J Cell Biol 143:1961-70. 1998..Taken together, these findings lead to the conclusion that the nonuniform MT polarity in podocytes established by CHO1/MKLP1 is necessary for process formation... - Structure and function of podocytes: an updateP Mundel
Department of Anatomy and Cell Biology I, University of Heidelberg, Germany
Anat Embryol (Berl) 192:385-97. 1995..A survey of podocyte function forms the center of this review. Finally, selected aspects of podocyte development and cell division are discussed... - Cell biological and biochemical characterization of drebrin complexes in mesangial cells and podocytes of renal glomeruliWiebke K Peitsch
Division of Cell Biology, German Cancer Research Center, Heidelberg, Germany
J Am Soc Nephrol 14:1452-63. 2003..Clearly, drebrin has to be added to the ensemble of ABP regulating the actomyosin system and the dynamics of mesangial cells and foot processes in podocytes... - CD2AP and p130Cas localize to different F-actin structures in podocytesT Welsch
Institute of Anatomy and Cell Biology I, University of Heidelberg, INF 307, D-69120 Heidelberg, Germany
Am J Physiol Renal Physiol 281:F769-77. 2001..Whereas p130Cas is found in focal adhesions, CD2AP seems to be involved in the regulation of highly dynamic F-actin structures in podocyte foot processes... - Stable expression of nephrin and localization to cell-cell contacts in novel murine podocyte cell linesDaniel Schiwek
Department of Anatomy and Cell Biology, University of Heidelberg, Heidelberg, Germany
Kidney Int 66:91-101. 2004..Furthermore, our data suggest that the accumulation of certain proteins in podocyte foot processes is linked to formation of cell-cell contacts... - SCG/Kinjoh mice: a model of ANCA-associated crescentic glomerulonephritis with immune depositsIrmgard Neumann
Fifth Department of Medicine, University Hospital Mannheim, Mannheim, Germany
Kidney Int 64:140-8. 2003..However, the spontaneous and concomitant development of pANCA, small vessel vasculitis, and CGN raises the opportunity to analyze pathogenetic links between these disease manifestations in vivo... - The LIM-homeodomain transcription factor Lmx1b plays a crucial role in podocytesClaudia Rohr
Institute for Anatomy and Cell Biology I, University of Heidelberg, Im Neuenheimer Feld 307, 69120 Heidelberg, Germany
J Clin Invest 109:1073-82. 2002.... - Oligonephronia, not exuberant apoptosis, accounts for the development of glomerulosclerosis in the bcl-2 knockout mouseN Gassler
Institut für Anatomie und Zellbiologie I, Universitat Heidelberg, Germany
Nephrol Dial Transplant 13:2509-18. 1998..The aim of the present study was to clarify whether the degenerative process in the kidneys seen after birth is based either on increased apoptosis of glomerular cells or on mechanisms independent from the genetic defect... - Ganglioside GM2-activator protein and vesicular transport in collecting duct intercalated cellsT M Mundel
Department of Anatomy and Cell Biology, University of Heidelberg, Germany
J Am Soc Nephrol 10:435-43. 1999..In this study, a novel role for GM2-activator protein in intercalated cells is proposed, and possible roles in the shuttling mechanism are discussed... - The role of the podocyte in glomerulosclerosisW Kriz
Institut fur Anatomie und Zellbiologie, INF 307, Universitat Heidelberg, Germany
Curr Opin Nephrol Hypertens 8:489-97. 1999..The recently described 'collapsing' variant, in contrast, has an apparent excess of extracapillary cells, which may represent dedifferentiated, 'dysregulated' podocytes... - Association of CD2AP with dynamic actin on vesicles in podocytesThilo Welsch
Department of Anatomy and Cell Biology, University of Heidelberg, D 69120 Heidelberg, Germany
Am J Physiol Renal Physiol 289:F1134-43. 2005.... - L-carnosine, a substrate of carnosinase-1, influences glucose metabolismSibylle Sauerhöfer
Institute for Anatomy and Cell Biology 1, University of Heidelberg, Heidelberg, Germany
Diabetes 56:2425-32. 2007..We therefore hypothesized that L-carnosine in the serum represents a critical protective factor in diabetic patients... - Altered expression pattern of polycystin-2 in acute and chronic renal tubular diseasesNicholas Obermüller
Medical Research Center, Klinikum Mannheim, University of Heidelberg, Mannheim, Germany
J Am Soc Nephrol 13:1855-64. 2002..After ischemia, polycystin-2 may be upregulated by the injured cells to protect themselves. It is unlikely that polycystin-2 plays a role in cyst formation in the (cy/+) rat and in the (pcy/pcy) mouse... - Analysis of differential gene expression in stretched podocytes: osteopontin enhances adaptation of podocytes to mechanical stressNicole Endlich
Department of Anatomy and Cell Biology, University of Heidelberg, D-69120 Heidelberg, Germany
FASEB J 16:1850-2. 2002..This study delineates the molecular response of podocytes to mechanical stress and identifies OPN as a stretch-adapting molecule in podocytes... - Podocytes are sensitive to fluid shear stress in vitroColin Friedrich
Department of Anatomy and Cell Biology I, University of Heidelberg, Heidelberg, Germany
Am J Physiol Renal Physiol 291:F856-65. 2006..Our data demonstrate that podocytes are highly sensitive to fluid shear stress. Shear stress induces a reorganization of the actin cytoskeleton and activates specific tyrosine kinases that are required to withstand fluid shear stress... - Movement of stress fibers away from focal adhesions identifies focal adhesions as sites of stress fiber assembly in stationary cellsNicole Endlich
Department of Anatomy and Cell Biology, Ernst Moritz Arndt University, D 17487 Greifswald, Germany
Cell Motil Cytoskeleton 64:966-76. 2007..Our finding of SF assembly at FAs has important implications for SF formation, force transmission, and tension distribution within the actin cytoskeletal network of stationary cells... - Palladin is a dynamic actin-associated protein in podocytesNicole Endlich
Department of Anatomy and Cell Biology, University of Greifswald, Greifswald, Germany
Kidney Int 75:214-26. 2009..Our study shows that palladin is expressed in podocytes and plays an important role in actin dynamics... - Differentially spliced isoforms of FAT1 are asymmetrically distributed within migrating cellsGerald S Braun
Institute for Anatomy and Cell Biology 1, University of Heidelberg, 69120 Heidelberg, Germany
J Biol Chem 282:22823-33. 2007..In summary, FAT1(WT) is the only FAT1 isoform located along the cellular leading edge. Only FAT1(WT) is up-regulated in migration, induces cellular process formation when overexpressed, and is necessary for efficient wound healing... - Progression of chronic renal failure in focal segmental glomerulosclerosis: consequence of podocyte damage or of tubulointerstitial fibrosis?Wilhelm Kriz
Pediatr Nephrol 18:617-22. 2003..The deleterious effects of protein leakage on progression appear to be a result of podocyte damage, the beneficial effects of ACE inhibitors a result of podocyte protection... - An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic miceMilena Traykova-Brauch
Department of Cellular and Molecular Pathology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
Nat Med 14:979-84. 2008..These experiments establish Pax8-rtTA mice as a powerful tool for modeling renal diseases in transgenic mice... - Abrogation of protein uptake through megalin-deficient proximal tubules does not safeguard against tubulointerstitial injuryFranziska Theilig
Institut für Vegetative Anatomie, Charite Universitatsmedizin Berlin, Philippstrasse 12, 10115 Berlin
J Am Soc Nephrol 18:1824-34. 2007.... - New insights into structural patterns encountered in glomerulosclerosisMichel LeHir
Anatomical Institute, University of Zurich, Zurich, Switzerland
Curr Opin Nephrol Hypertens 16:184-91. 2007..Our aim was to survey those models in an attempt to discover correlations between histopathological patterns and pathogenic mechanisms... - In mice, proteinuria and renal inflammatory responses to albumin overload are strain-dependentDavid A Ishola
Department of Nephrology, University Medical Center, Utrecht, The Netherlands
Nephrol Dial Transplant 21:591-7. 2006.... - Podocytes as a target for treatment with ACE inhibitors and/or angiotensin-receptor blockersWilhelm Kriz
Kidney Int 65:333-4. 2004 - The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodiesUlrike Fiedler
Department of Vascular Biology and Angiogenesis Research Tumor Biology Center, Breisacher Str 117, 79106 Freiburg, Germany
Blood 103:4150-6. 2004.... - Cell biology of the glomerular podocyteHermann Pavenstadt
Division of Nephrology, Department of Medicine, University Hospital Freiburg, Freiburg, Germany
Physiol Rev 83:253-307. 2003..This review integrates our recent physiological and molecular understanding of the role of podocytes during the maintenance and failure of the glomerular filtration barrier... - C-type natriuretic peptide as a podocyte hormone and modulation of its cGMP production by glucose and mechanical stressBarbara Lewko
Department of Immunopathology, Medical University of Gdansk, Gdansk, Poland
Kidney Int 66:1001-8. 2004..We investigated whether mechanical stress and high ambient glucose influence cGMP generation in podocytes stimulated with NPs. Additionally, the C-type natriuretic peptide (CNP) system has been characterized in these cells... - Fenestrated glomerular capillaries are uniqueWilhelm Kriz
J Am Soc Nephrol 19:1439-40. 2008 - Characterization of glucose uptake by cultured rat podocytesBarbara Lewko
Department of Immunopathology, Medical University of Gdansk, Gdansk, Poland
Kidney Blood Press Res 28:1-7. 2005..It seems likely that a sodium-dependent glucose cotransporter may also be present in these cells... - Hypertrophy of podocytes: a mechanism to cope with increased glomerular capillary pressures?Wilhelm Kriz
Kidney Int 67:373-4. 2005 - Introduction to the podocyte issue: more than eight enigmasNaoto Kobayashi
Department of Anatomy and Embryology, Ehime University School of Medicine, Ehime, 791-0295 Japan
Microsc Res Tech 57:187-8. 2002 - Lack of connexin 40 causes displacement of renin-producing cells from afferent arterioles to the extraglomerular mesangiumLisa Kurtz
Physiologisches Institut der Universität Regensburg, D 93040 Regensburg, Germany
J Am Soc Nephrol 18:1103-11. 2007..Moreover, these findings support the notion that gap junctions are relevant for the macula densa signaling to renin-producing cells...