M Kretzler

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi request reprint Detection of multiple vascular endothelial growth factor splice isoforms in single glomerular podocytes
    M Kretzler
    Medizinische Poliklinik and Physiologisches Institut, Universitat Munchen, Germany
    Kidney Int Suppl 67:S159-61. 1998
  2. ncbi request reprint Repuncturing the renal biopsy: strategies for molecular diagnosis in nephrology
    Matthias Kretzler
    Medizinische Poliklinik, University of Munich, Schillerstrasse 42, 80336 Munich, Germany
    J Am Soc Nephrol 13:1961-72. 2002
  3. ncbi request reprint Regulation of adhesive interaction between podocytes and glomerular basement membrane
    Matthias Kretzler
    Medizinische Poliklinik, University of Munich, Munich, Germany
    Microsc Res Tech 57:247-53. 2002
  4. ncbi request reprint Altering glomerular epithelial function in vitro using transient and stable transfection
    M Kretzler
    Medical Poliklinik, University of Munich, Munich, Germany
    J Nephrol 14:211-9. 2001
  5. ncbi request reprint The apoptosis mediator mDAP-3 is a novel member of a conserved family of mitochondrial proteins
    T Berger
    Medizinische Poliklinik and Physiologische Chemie, Universitat Munchen, Germany
    J Cell Sci 113:3603-12. 2000
  6. ncbi request reprint Chemokine and chemokine receptor expression during initiation and resolution of immune complex glomerulonephritis
    H J Anders
    Nephrological Center, Medical Policlinic, Ludwig-Maximilians-University Munich, Munich, Germany
    J Am Soc Nephrol 12:919-31. 2001
  7. ncbi request reprint Expression of the chemokine receptor CXCR1 in human glomerular diseases
    S Segerer
    Medizinische Poliklinik Innenstadt, University of Munich, Germany
    Kidney Int 69:1765-73. 2006
  8. ncbi request reprint Viral double-stranded RNA aggravates lupus nephritis through Toll-like receptor 3 on glomerular mesangial cells and antigen-presenting cells
    Prashant S Patole
    Nephrological Center, Medical Policlinic, Ludwig Maximilians University, Munich, Germany
    J Am Soc Nephrol 16:1326-38. 2005
  9. ncbi request reprint Gene expression profiling analysis in nephrology: towards molecular definition of renal disease
    Yoshinari Yasuda
    Nephrologische Zentrum, Medizinische Poliklinik, Ludwig Maximilians Universtaet, Schillerstrasse 42, D 80336, Munich, Germany
    Clin Exp Nephrol 10:91-8. 2006
  10. pmc Comparative promoter analysis allows de novo identification of specialized cell junction-associated proteins
    Clemens D Cohen
    Medizinische Poliklinik, University of Munich, 80336 Munich, Germany
    Proc Natl Acad Sci U S A 103:5682-7. 2006

Collaborators

Detail Information

Publications66

  1. ncbi request reprint Detection of multiple vascular endothelial growth factor splice isoforms in single glomerular podocytes
    M Kretzler
    Medizinische Poliklinik and Physiologisches Institut, Universitat Munchen, Germany
    Kidney Int Suppl 67:S159-61. 1998
    ..Our approach should allow a semiquantitative, isoform-specific evaluation of VEGF mRNA expression in podocytes during nephrogenesis and in glomerular disease...
  2. ncbi request reprint Repuncturing the renal biopsy: strategies for molecular diagnosis in nephrology
    Matthias Kretzler
    Medizinische Poliklinik, University of Munich, Schillerstrasse 42, 80336 Munich, Germany
    J Am Soc Nephrol 13:1961-72. 2002
    ..It is hoped that this outlook will lead to stimulating discussions and the implementation of these innovative ideas in nephrology...
  3. ncbi request reprint Regulation of adhesive interaction between podocytes and glomerular basement membrane
    Matthias Kretzler
    Medizinische Poliklinik, University of Munich, Munich, Germany
    Microsc Res Tech 57:247-53. 2002
    ..Examining podocyte function in tissue culture, animal models and human expression studies should allow further detailed dissection of the molecular pathways responsible for maintenance and failure of the glomerular filtration barrier...
  4. ncbi request reprint Altering glomerular epithelial function in vitro using transient and stable transfection
    M Kretzler
    Medical Poliklinik, University of Munich, Munich, Germany
    J Nephrol 14:211-9. 2001
    ..The insight gained through these and comparable systems should allow a detailed dissection of the molecular pathways active in GEC function and failure...
  5. ncbi request reprint The apoptosis mediator mDAP-3 is a novel member of a conserved family of mitochondrial proteins
    T Berger
    Medizinische Poliklinik and Physiologische Chemie, Universitat Munchen, Germany
    J Cell Sci 113:3603-12. 2000
    ..These data identify mDAP-3 as one of the first proapoptotic factors in the mitochondrial matrix and provide evidence for a critical, evolutionary conserved role of members of the DAP-3 protein family for mitochondrial biogenesis...
  6. ncbi request reprint Chemokine and chemokine receptor expression during initiation and resolution of immune complex glomerulonephritis
    H J Anders
    Nephrological Center, Medical Policlinic, Ludwig-Maximilians-University Munich, Munich, Germany
    J Am Soc Nephrol 12:919-31. 2001
    ..After initiating GN, MCP-1 and RANTES and their receptors are readily downregulated...
  7. ncbi request reprint Expression of the chemokine receptor CXCR1 in human glomerular diseases
    S Segerer
    Medizinische Poliklinik Innenstadt, University of Munich, Germany
    Kidney Int 69:1765-73. 2006
    ..CXCR1 might be involved in the recruitment of PMNs to the glomerular tuft, which could be targeted by CXCR1-blocking agents...
  8. ncbi request reprint Viral double-stranded RNA aggravates lupus nephritis through Toll-like receptor 3 on glomerular mesangial cells and antigen-presenting cells
    Prashant S Patole
    Nephrological Center, Medical Policlinic, Ludwig Maximilians University, Munich, Germany
    J Am Soc Nephrol 16:1326-38. 2005
    ..g., glomerular mesangial cells, to produce cytokines and chemokines, factors that can aggravate autoimmune tissue injury, e.g., lupus nephritis...
  9. ncbi request reprint Gene expression profiling analysis in nephrology: towards molecular definition of renal disease
    Yoshinari Yasuda
    Nephrologische Zentrum, Medizinische Poliklinik, Ludwig Maximilians Universtaet, Schillerstrasse 42, D 80336, Munich, Germany
    Clin Exp Nephrol 10:91-8. 2006
    ..Finally, an outlook towards the emerging proteomic studies of renal disease will be given...
  10. pmc Comparative promoter analysis allows de novo identification of specialized cell junction-associated proteins
    Clemens D Cohen
    Medizinische Poliklinik, University of Munich, 80336 Munich, Germany
    Proc Natl Acad Sci U S A 103:5682-7. 2006
    ..Nephrin, ZO-1, and cadherin-5 mRNA showed stringent coexpression across a diverse set of human glomerular diseases. Comparative promoter analysis can identify regulatory pathways at work in tissue homeostasis and disease processes...
  11. ncbi request reprint Molecular approaches to chronic kidney disease
    Holger Schmid
    Medizinische Poliklinik, Klinikum der Universitat Munchen, Munich, Germany
    Curr Opin Nephrol Hypertens 15:123-9. 2006
    ..Current approaches to identifying the molecular markers required to implement this 'personalized medicine' concept in progressive renal failure will be presented in this review...
  12. ncbi request reprint Differential expression of profibrotic and growth factors in chronic allograft nephropathy
    Hilary Hotchkiss
    Pediatric Nephrology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Transplantation 81:342-9. 2006
    ..Chronic allograft nephropathy (CAN) is a multifactorial process, where both immunological and nonimmunological factors play roles. Microarrays detect thousands of genes simultaneously...
  13. pmc Novel role of toll-like receptor 3 in hepatitis C-associated glomerulonephritis
    Markus Wornle
    Medical Policlinic, Ludwig Maximilians University, Munchen, Germany
    Am J Pathol 168:370-85. 2006
    ..Thus, TLR3 expression on renal cells, and especially MCs, may establish a link between viral infections and glomerular diseases...
  14. ncbi request reprint Toll-like receptor-4: renal cells and bone marrow cells signal for neutrophil recruitment during pyelonephritis
    Prashant S Patole
    Medizinische Poliklinik Innenstadt, University of Munich, Munich, Germany
    Kidney Int 68:2582-7. 2005
    ..Toll-like receptor-4 (TLR4) mutant mice infected with uropathogenic Escherichia coli lack renal CXCL2 mRNA expression, subsequent neutrophil recruitment, and renal abscess formation...
  15. ncbi request reprint Toll-like receptor-7 modulates immune complex glomerulonephritis
    Rahul D Pawar
    Nephrological Center, Medical Policlinic, University of Munich, Munich, Germany
    J Am Soc Nephrol 17:141-9. 2006
    ....
  16. ncbi request reprint Expression of gremlin, a bone morphogenetic protein antagonist, in human diabetic nephropathy
    Vincent Dolan
    Department of Medicine, The Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Mater Misericordiae University Hospital, Dublin, Ireland
    Am J Kidney Dis 45:1034-9. 2005
    ..We report the induction of gremlin, a bone morphogenetic protein antagonist, in cultured human mesangial cells exposed to high glucose and transforming growth factor beta (TGF-beta) levels in vitro and kidneys from diabetic rats in vivo...
  17. ncbi request reprint Sam68-like mammalian protein 2, identified by digital differential display as expressed by podocytes, is induced in proteinuria and involved in splice site selection of vascular endothelial growth factor
    Clemens D Cohen
    Medizinische Poliklinik, Ludwig Maximilians University, Pettenkoferstrasse 8a, Munich, 80336, Germany
    J Am Soc Nephrol 16:1958-65. 2005
    ..SLM-2-dependent VEGF splicing indicates the importance of mRNA splice site selection for glomerular filtration barrier function...
  18. ncbi request reprint BK virus associated nephropathy in native kidneys of a heart allograft recipient
    Holger Schmid
    Nephrologisches Zentrum Niedersachsen, Hann Münden, Germany
    Am J Transplant 5:1562-8. 2005
    ..In conclusion, polyomavirus reactivation in native kidneys of heart transplant recipients can cause significant renal impairment and should be considered in the differential diagnosis in this patient cohort...
  19. ncbi request reprint Formation and phosphorylation of the PINCH-1-integrin linked kinase-alpha-parvin complex are important for regulation of renal glomerular podocyte adhesion, architecture, and survival
    Yanqiang Yang
    707B Scaife Hall, Department of Pathology, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    J Am Soc Nephrol 16:1966-76. 2005
    ..These results provide important evidence for a crucial role of the PINCH-1-ILK-alpha-parvin complex in the control of podocyte adhesion, morphology, and survival...
  20. ncbi request reprint Loss of the tumor suppressor Vhlh leads to upregulation of Cxcr4 and rapidly progressive glomerulonephritis in mice
    Mei Ding
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    Nat Med 12:1081-7. 2006
    ..Collectively, these results indicate an alternative mechanism for the pathogenesis of RPGN and glomerular disease in an animal model and suggest novel molecular pathways for intervention in this disease...
  21. ncbi request reprint Antitumoral activity of rapamycin in renal angiomyolipoma associated with tuberous sclerosis complex
    Ralf Wienecke
    Department of Dermatology, Tuberous Sclerosis Center, Ludwig Maximilian University Munich, Gemany
    Am J Kidney Dis 48:e27-9. 2006
    ..During this time, the renal angiomyolipoma shrank significantly, regrew during an 8-month period, and decreased in size again after readministration of rapamycin...
  22. ncbi request reprint Modular activation of nuclear factor-kappaB transcriptional programs in human diabetic nephropathy
    Holger Schmid
    Division of Nephrology, Medizinische Poliklinik, University of Munich, Pettenkoferstr 8a, 80336 Munich, Germany
    Diabetes 55:2993-3003. 2006
    ....
  23. pmc Proteinuria and hyperglycemia induce endoplasmic reticulum stress
    Maja T Lindenmeyer
    Nephrology Center, Medizinische Poliklinik, University of Munich, Munich, Germany
    J Am Soc Nephrol 19:2225-36. 2008
    ..Although this may protect the cells from ER stress, persistence of hyperglycemia and proteinuria may eventually lead to apoptosis...
  24. pmc IHG-1 amplifies TGF-beta1 signaling and is increased in renal fibrosis
    Madeline Murphy
    UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    J Am Soc Nephrol 19:1672-80. 2008
    ..In summary, IHG-1, which increases in diabetic nephropathy, may enhance the actions of TGF-beta1 and contribute to the development of tubulointerstitial fibrosis...
  25. pmc Maternal environment interacts with modifier genes to influence progression of nephrotic syndrome
    Julien Ratelade
    INSERM, U574, Hopital Necker Enfants Malades, 149 rue de Sevres, 75015 Paris, France
    J Am Soc Nephrol 19:1491-9. 2008
    ..In summary, constitutive inactivation of podocin models the complex interactions between maternal and genetically determined factors on the progression of renal disease as a result of nephrotic syndrome in mice...
  26. doi request reprint Notch inhibition reverses kidney failure
    Matthias Kretzler
    Nat Med 14:246-7. 2008
  27. ncbi request reprint Modification of kidney barrier function by the urokinase receptor
    Changli Wei
    Nephrology Division and Program in Glomerular Disease, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    Nat Med 14:55-63. 2008
    ..Blockade of alphavbeta3 integrin reduces podocyte motility in vitro and lowers proteinuria in mice. Our findings show a physiological role for uPAR signaling in the regulation of kidney permeability...
  28. pmc Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition
    Debra F Higgins
    Department of Medicine, Renal Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 117:3810-20. 2007
    ....
  29. ncbi request reprint Co-regulation of Gremlin and Notch signalling in diabetic nephropathy
    David W Walsh
    UCD School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, Ireland
    Biochim Biophys Acta 1782:10-21. 2008
    ..Together, these data suggest that Notch pathway gene expression is elevated in diabetic nephropathy, co-incident with Gremlin, and may contribute to the pathogenesis of this disease...
  30. ncbi request reprint Interstitial vascular rarefaction and reduced VEGF-A expression in human diabetic nephropathy
    Maja T Lindenmeyer
    Nephrologisches Zentrum, Medizinische Poliklinik, University of Munich, Pettenkoferstrasse 8a, 80336 Munich, Germany
    J Am Soc Nephrol 18:1765-76. 2007
    ..These findings and the questions about rodent models in DN raise a note of caution regarding the proposal to inhibit VEGF-A to prevent progression of DN...
  31. ncbi request reprint Expression of filtrin in human glomerular diseases
    Pekka Ihalmo
    Department of Bacteriology and Immunology, Haartman Institute, Biomedicum Helsinki, University of Helsinki, Finland, and Renal Immunopathology Laboratory, Fondazione D Amico per la Ricerca sulle Malattie Renali, San Carlo Borromeo Hospital, Milan, Italy
    Nephrol Dial Transplant 22:1903-9. 2007
    ..In this study, the gene and protein expression of filtrin were examined in patients with acquired proteinuric diseases...
  32. ncbi request reprint Expression of the chemokine receptor CCR1 in human renal allografts
    Verena Mayer
    Medizinische Poliklinik Innenstadt, Pettenkoferstrasse 8a, 80336 Munich, Germany
    Nephrol Dial Transplant 22:1720-9. 2007
    ..CCR1 is a receptor for various proinflammatory chemokines and CCR1 blockade reduces renal allograft injury in rabbits. The purpose of the study was to characterize CCR1-positive cells in human renal allografts...
  33. pmc The contribution of B cells to renal interstitial inflammation
    Florian Heller
    Medizinische Poliklinik Innenstadt, University of Munich, Germany
    Am J Pathol 170:457-68. 2007
    ..CXCR5-positive B cells might be recruited via the chemokine CXCL13 and seem to contribute to the formation of intrarenal lymphoid follicle-like structures. These might represent an intrarenal immune system...
  34. ncbi request reprint TGF-beta1 regulates the PINCH-1-integrin-linked kinase-alpha-parvin complex in glomerular cells
    Kyu Yong Jung
    Department of Pathology, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    J Am Soc Nephrol 18:66-73. 2007
    ....
  35. ncbi request reprint Induction of TRPC6 channel in acquired forms of proteinuric kidney disease
    Clemens C Möller
    Department of Medicine, Nephrology Division, Massachusetts General Hospital and Harvard Medical School, MGH East, 149 13th Street, Boston, MA 02129, USA
    J Am Soc Nephrol 18:29-36. 2007
    ..These studies suggest the involvement of TRPC6 in the pathology of nongenetic forms of proteinuric disease...
  36. ncbi request reprint Delayed chemokine receptor 1 blockade prolongs survival in collagen 4A3-deficient mice with Alport disease
    Volha Ninichuk
    Nephrological Center, Medical Policlinic, University of Munich, Germany
    J Am Soc Nephrol 16:977-85. 2005
    ..These data identify CCR1 as a potential therapeutic target for Alport disease or other progressive nephropathies associated with interstitial macrophage infiltrates...
  37. ncbi request reprint Functional consequences of integrin-linked kinase activation in podocyte damage
    Vicente de Paulo Castro Teixeira
    Medizinische Poliklinik, Universitat Munchen, Munich, Germany
    Kidney Int 67:514-23. 2005
    ..The aim of this study was to elucidate the molecular mechanisms of ILK dependant phenotype regulation in podocytes...
  38. ncbi request reprint Post-translational and cell type-specific regulation of CXCR4 expression by cytokines
    Hilke Bruhl
    Medical Policlinic, University of Munich, Munich, Germany
    Eur J Immunol 33:3028-37. 2003
    ..Internalization of CXCR4 by cytokines in a cell type-specific manner is a novel and functionally important mechanism of chemokine receptor regulation...
  39. ncbi request reprint Gene expression profiles of podocyte-associated molecules as diagnostic markers in acquired proteinuric diseases
    Holger Schmid
    Medizinische Poliklinik, Ludwig Maximilians University of Munich, Munich, Germany
    J Am Soc Nephrol 14:2958-66. 2003
    ..As the above approach can be performed as an add-on diagnostic tool, these molecular diagnostic parameters could give novel information for the management of proteinuric diseases...
  40. ncbi request reprint Gene-expression analysis of microdissected renal biopsies
    Clemens D Cohen
    Medizinische Poliklinik, University of Munich, Munich, Germany
    Methods Mol Med 86:285-93. 2003
  41. ncbi request reprint Modification of the transcriptomic response to renal ischemia/reperfusion injury by lipoxin analog
    Niamh E Kieran
    Human Genomics and Bioinformatics Research Unit, Department of Medicine and Therapeutics, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Mater Misericordiae Hospital, Dublin 7, Ireland
    Kidney Int 64:480-92. 2003
    ....
  42. ncbi request reprint Validation of endogenous controls for gene expression analysis in microdissected human renal biopsies
    Holger Schmid
    Medizinische Poliklinik, Ludwig Maximilians University of Munich, Munich, Germany
    Kidney Int 64:356-60. 2003
    ..The appropriate choice of an internal reference is critical for quantitative RNA analysis. However, no comparison of frequently used "housekeeping" genes is available for renal biopsy studies...
  43. ncbi request reprint Bacterial CpG-DNA aggravates immune complex glomerulonephritis: role of TLR9-mediated expression of chemokines and chemokine receptors
    Hans Joachim Anders
    Nephrological Center, Medical Policlinic, University of Munich, Munich, Germany
    J Am Soc Nephrol 14:317-26. 2003
    ..This mechanism may be relevant during infection-triggered exacerbation of human immune-complex GN and other immune-mediated diseases in general...
  44. ncbi request reprint Identification of a signal transduction pathway that regulates MMP-9 mRNA expression in glomerular injury
    Irene von Lüttichau
    Medizinische Poliklinik, Ludwig Maximilians Universitat, Munchen, Germany
    Biol Chem 383:1271-5. 2002
    ....
  45. ncbi request reprint TRAIL-induced apoptosis is independent of the mitochondrial apoptosis mediator DAP3
    Thorsten Berger
    Klinische Biochemie der Medizinischen Poliklinik, Universitat Munchen, Schillerstrasse 42, D 80336 Munich, Germany
    Biochem Biophys Res Commun 297:880-4. 2002
    ..Therefore, DAP3 and FADD interact only in vitro after disruption of the cellular compartments. TRAIL-induced and DR4-mediated apoptosis in Jurkat cells is independent of DAP3...
  46. ncbi request reprint Roles of SLC/CCL21 and CCR7 in human kidney for mesangial proliferation, migration, apoptosis, and tissue homeostasis
    Bernhard Banas
    Medical Policlinic, Ludwig Maximilians University, Munich, Germany
    J Immunol 168:4301-7. 2002
    ....
  47. ncbi request reprint Spatial and temporally restricted expression of chemokines and chemokine receptors in the developing human kidney
    Hermann Josef Grone
    Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany
    J Am Soc Nephrol 13:957-67. 2002
    ..Because genes that are expressed during ontogeny often play a role in tissue regeneration, these embryonal chemokine/chemokine receptor patterns may be important in renal injury and repair...
  48. pmc A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligation
    Hans Joachim Anders
    Nephrological Center, Medizinische Poliklinik, Innenstadt, Universitat Munchen, Munchen, Germany
    J Clin Invest 109:251-9. 2002
    ..We therefore conclude that CCR1 blockade may represent a new therapeutic strategy for reducing cellular infiltration and renal fibrosis as major factors in the progression to end-stage renal failure...
  49. ncbi request reprint Quantitative gene expression analysis in renal biopsies: a novel protocol for a high-throughput multicenter application
    Clemens D Cohen
    Medizinische Poliklinik, Ludwig Maximilians University of Munich, Munich, Germany
    Kidney Int 61:133-40. 2002
    ..Recent advances in gene expression analysis may add the quantification of mRNA species in renal biopsies to routine diagnostic procedures in nephrology...
  50. ncbi request reprint Laser microdissection and gene expression analysis on formaldehyde-fixed archival tissue
    Clemens D Cohen
    Medizinische Poliklinik, Ludwig Maximilians University of Munich, Munich, Germany
    Kidney Int 61:125-32. 2002
    ..However, quantification of mRNA expression in human renal biopsies thus far has not been possible in formaldehyde-fixed tissue...
  51. pmc Early glomerular filtration defect and severe renal disease in podocin-deficient mice
    Séverine Roselli
    Inserm U574, Hopital Necker Enfants Malades, Universite Rene Descartes, Tour Lavoisier 6ème étage, 75743 Paris, France
    Mol Cell Biol 24:550-60. 2004
    ....
  52. ncbi request reprint Activation of toll-like receptor-9 induces progression of renal disease in MRL-Fas(lpr) mice
    Hans Joachim Anders
    Nephrological Center, Medical Policlinic, Ludwig Maximilians University Munich, Germany
    FASEB J 18:534-6. 2004
    ..We conclude that TLR9 activation triggers disease activity of systemic autoimmunity, for example, lupus nephritis, and that adaptive and innate immune mechanisms contribute to the CpG-DNA-induced progression of lupus nephritis...
  53. ncbi request reprint CCR1 blockade reduces interstitial inflammation and fibrosis in mice with glomerulosclerosis and nephrotic syndrome
    Volker Vielhauer
    Nephrologisches Zentrum, Medizinische Poliklinik Innenstadt, Ludwig Maximilians University, Munich, Germany
    Kidney Int 66:2264-78. 2004
    ..We therefore studied the effect of the small-molecule CCR1 antagonist BX471 in a murine model of adriamycin-induced focal segmental glomerulosclerosis (FSGS) with nephrotic syndrome and progressive interstitial inflammation and fibrosis...
  54. ncbi request reprint Binding of the chemokine SLC/CCL21 to its receptor CCR7 increases adhesive properties of human mesangial cells
    Bernhard Banas
    Nephrologisches Zentrum, Medizinische Poliklinik, Ludwig Maximilians Universitat Munchen, Germany
    Kidney Int 66:2256-63. 2004
    ..In leukocytes chemokines mediate integrin-dependent firm adhesion. Therefore, we examined the influence of chemokine receptor CCR7 activation by SLC/CCL21 on adhesive properties of human mesangial cells to matrix molecules...
  55. ncbi request reprint Role of podocytes for reversal of glomerulosclerosis and proteinuria in the aging kidney after endothelin inhibition
    Jana Ortmann
    Medizinische Poliklinik, Universitatsspital Zurich, Switzerland
    Hypertension 44:974-81. 2004
    ..The results further suggest that age-dependent glomerulosclerosis is not merely a "degenerative" but a reversible process locally confined to the glomerulus involving recovery of podocytes from previous injury...
  56. ncbi request reprint Reduced intragraft mRNA expression of matrix metalloproteinases Mmp3, Mmp12, Mmp13 and Adam8, and diminished transplant arteriosclerosis in Ccr5-deficient mice
    Bruno Luckow
    Klinikum der Universitat Munchen, Medizinische Poliklinik Innenstadt, Munchen, Germany
    Eur J Immunol 34:2568-78. 2004
    ..We conclude that early tissue remodeling may be a critical feature in the predisposition of allografts to the development of chronic dysfunction...
  57. pmc Influence of native and hypochlorite-modified low-density lipoprotein on gene expression in human proximal tubular epithelium
    Stefan Porubsky
    Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany
    Am J Pathol 164:2175-87. 2004
    ....
  58. ncbi request reprint Late onset of treatment with a chemokine receptor CCR1 antagonist prevents progression of lupus nephritis in MRL-Fas(lpr) mice
    Hans Joachim Anders
    Nephrological Center, Medical Policlinic, Ludwig Maximilians University Munich, Pettenkoferstrasse 8a, 80336 Munich, Germany
    J Am Soc Nephrol 15:1504-13. 2004
    ..This is the first evidence that, in advanced chronic renal injury, blockade of CCR1 can halt disease progression and improve renal function by selective inhibition of interstitial leukocyte recruitment and fibrosis...
  59. ncbi request reprint New immunosuppressive strategies in renal transplant recipients
    Michael Fischereder
    Nephrology Center, Medizinische Poliklinik Innenstadt, Ludwig Maximilians University, Munich, Germany
    J Nephrol 17:9-18. 2004
    ..While selection of one of these strategies may allow a more individualised therapy, the immunosuppressive potential of each compound has to be weighed against adverse reactions for an individual patient...
  60. pmc Induction of B7-1 in podocytes is associated with nephrotic syndrome
    Jochen Reiser
    Department of Medicine, Albert Einstein College of Medicine, New York, New York 10461, USA
    J Clin Invest 113:1390-7. 2004
    ..Our findings suggest a novel function for B7-1 in danger signaling by nonimmune cells...
  61. ncbi request reprint Gene expression analysis of human renal biopsies: recent developments towards molecular diagnosis of kidney disease
    Anna Henger
    Nephrologisches Zentrum, Medizinische Poliklinik, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Curr Opin Nephrol Hypertens 13:313-8. 2004
    ..Recent progress in gene expression-based tissue analysis may provide fundamentally novel information in renal biopsy interpretation. In this review, progress towards the routine application of this approach is summarized...
  62. ncbi request reprint Gene expression analysis in renal biopsies
    Holger Schmid
    Nephrol Dial Transplant 19:1347-51. 2004
  63. ncbi request reprint Gene expression fingerprints in human tubulointerstitial inflammation and fibrosis as prognostic markers of disease progression
    Anna Henger
    Medical Policlinic, University of Munich, Munich, Germany
    Kidney Int 65:904-17. 2004
    ..To test molecular based renal disease categorization, differential gene expression profiles were compared between control and hydronephrotic kidneys showing varying degrees of inflammation and fibrosis...
  64. ncbi request reprint Chemokine receptor CCR1 but not CCR5 mediates leukocyte recruitment and subsequent renal fibrosis after unilateral ureteral obstruction
    Vaclav Eis
    Nephrological Center, Medical Policlinic, University of Munich, Munich, Germany
    J Am Soc Nephrol 15:337-47. 2004
    ..Therefore, CCR1 is a promising target for therapeutic intervention in leukocyte-mediated fibrotic tissue injury, e.g. progressive renal fibrosis...
  65. pmc CXCR3 is involved in tubulointerstitial injury in human glomerulonephritis
    Stephan Segerer
    Medizinische Poliklinik Innenstadt, University of Munich, Munich, Germany
    Am J Pathol 164:635-49. 2004
    ..Therefore interstitial CXCR3, as well as CCR5-positive T cells might play an important role during progressive loss of renal function, and are potential therapeutic targets in human glomerular diseases...
  66. ncbi request reprint Interaction of DAP3 and FADD only after cellular disruption
    Thorsten Berger
    Nat Immunol 3:3-5. 2002