Simone Kreth

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. doi request reprint MicroRNA-150 inhibits expression of adiponectin receptor 2 and is a potential therapeutic target in patients with chronic heart failure
    Simone Kreth
    Department of Anesthesiology, Ludwig Maximilians University Munich, Munich, Germany Electronic address
    J Heart Lung Transplant 33:252-60. 2014
  2. doi request reprint In human glioblastomas transcript elongation by alternative polyadenylation and miRNA targeting is a potent mechanism of MGMT silencing
    Simone Kreth
    Research Group Molecular Medicine, Department of Anesthesiology, University of Munich LMU, Marchioninistrasse 15, 81337, Munich, Germany
    Acta Neuropathol 125:671-81. 2013
  3. pmc Selection of reliable reference genes for quantitative real-time PCR in human T cells and neutrophils
    Carola Ledderose
    Department of Anesthesiology, Ludwig Maximilians University Munich, Germany
    BMC Res Notes 4:427. 2011
  4. doi request reprint Predominant influence of MGMT methylation in non-resectable glioblastoma after radiotherapy plus temozolomide
    Niklas Thon
    Department of Neurosurgery, University Hospital Großhadern, Ludwig Maximilians Universitat Munchen, Munich, Germany
    J Neurol Neurosurg Psychiatry 82:441-6. 2011
  5. pmc O-methylguanine-DNA methyltransferase (MGMT) mRNA expression predicts outcome in malignant glioma independent of MGMT promoter methylation
    Simone Kreth
    Department of Anaesthesiology, Ludwig Maximilians University, Munich, Germany
    PLoS ONE 6:e17156. 2011
  6. doi request reprint IDH1 mutations in grade II astrocytomas are associated with unfavorable progression-free survival and prolonged postrecurrence survival
    Niklas Thon
    Department of Neurosurgery, Ludwig Maximilians University, Munich, Germany
    Cancer 118:452-60. 2012
  7. doi request reprint Adenosine A2A receptor upregulation in human PMNs is controlled by miRNA-214, miRNA-15, and miRNA-16
    Jens Heyn
    Department of Anaesthesiology, University of Munich, Munich, Germany
    Shock 37:156-63. 2012
  8. ncbi request reprint Corticosteroid resistance in sepsis is influenced by microRNA-124--induced downregulation of glucocorticoid receptor-α
    Carola Ledderose
    Department of Anesthesiology, University of Munich, Germany
    Crit Care Med 40:2745-53. 2012
  9. doi request reprint Substantially altered expression pattern of cannabinoid receptor 2 and activated endocannabinoid system in patients with severe heart failure
    Florian Weis
    Department of Anesthesiology, Ludwig Maximilians University, Munich, Germany
    J Mol Cell Cardiol 48:1187-93. 2010
  10. doi request reprint Altered myocardial expression of ghrelin and its receptor (GHSR-1a) in patients with severe heart failure
    Andres Beiras-Fernandez
    Department of Cardiac Surgery, Ludwig Maximilian University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Peptides 31:2222-8. 2010

Collaborators

Detail Information

Publications21

  1. doi request reprint MicroRNA-150 inhibits expression of adiponectin receptor 2 and is a potential therapeutic target in patients with chronic heart failure
    Simone Kreth
    Department of Anesthesiology, Ludwig Maximilians University Munich, Munich, Germany Electronic address
    J Heart Lung Transplant 33:252-60. 2014
    ..We aimed to characterize the expression of adiponectin and its receptors in CHF and to assess the impact of microRNAs on the cardiac adiponectin system...
  2. doi request reprint In human glioblastomas transcript elongation by alternative polyadenylation and miRNA targeting is a potent mechanism of MGMT silencing
    Simone Kreth
    Research Group Molecular Medicine, Department of Anesthesiology, University of Munich LMU, Marchioninistrasse 15, 81337, Munich, Germany
    Acta Neuropathol 125:671-81. 2013
    ..Taken together, our results uncovered alternative polyadenylation of the MGMT 3'-UTR and miRNA targeting as new mechanisms of MGMT silencing...
  3. pmc Selection of reliable reference genes for quantitative real-time PCR in human T cells and neutrophils
    Carola Ledderose
    Department of Anesthesiology, Ludwig Maximilians University Munich, Germany
    BMC Res Notes 4:427. 2011
    ..abstract:..
  4. doi request reprint Predominant influence of MGMT methylation in non-resectable glioblastoma after radiotherapy plus temozolomide
    Niklas Thon
    Department of Neurosurgery, University Hospital Großhadern, Ludwig Maximilians Universitat Munchen, Munich, Germany
    J Neurol Neurosurg Psychiatry 82:441-6. 2011
    ..Unfortunately, no data are available concerning the predictive value of O(6)-methylguanine-DNA methyltransferase (MGMT) promoter methylation for this important subpopulation. For clarification, a prospective study was conducted...
  5. pmc O-methylguanine-DNA methyltransferase (MGMT) mRNA expression predicts outcome in malignant glioma independent of MGMT promoter methylation
    Simone Kreth
    Department of Anaesthesiology, Ludwig Maximilians University, Munich, Germany
    PLoS ONE 6:e17156. 2011
    ....
  6. doi request reprint IDH1 mutations in grade II astrocytomas are associated with unfavorable progression-free survival and prolonged postrecurrence survival
    Niklas Thon
    Department of Neurosurgery, Ludwig Maximilians University, Munich, Germany
    Cancer 118:452-60. 2012
    ..The favorable prognostic impact of mutations in the IDH1 gene is well documented for malignant gliomas; its influence on World Health Organization (WHO) grade II astrocytomas, however, is still under debate...
  7. doi request reprint Adenosine A2A receptor upregulation in human PMNs is controlled by miRNA-214, miRNA-15, and miRNA-16
    Jens Heyn
    Department of Anaesthesiology, University of Munich, Munich, Germany
    Shock 37:156-63. 2012
    ..Determination of miRNA expression levels may help to identify patients with an increased risk for severe inflammation...
  8. ncbi request reprint Corticosteroid resistance in sepsis is influenced by microRNA-124--induced downregulation of glucocorticoid receptor-α
    Carola Ledderose
    Department of Anesthesiology, University of Munich, Germany
    Crit Care Med 40:2745-53. 2012
    ..We hypothesized that 1) changes of the ratio of glucocorticoid receptor isoforms impact glucocorticoid resistance and 2) glucocorticoid receptor-α expression is controlled by microRNA-mediated gene silencing...
  9. doi request reprint Substantially altered expression pattern of cannabinoid receptor 2 and activated endocannabinoid system in patients with severe heart failure
    Florian Weis
    Department of Anesthesiology, Ludwig Maximilians University, Munich, Germany
    J Mol Cell Cardiol 48:1187-93. 2010
    ..These results might open up new perspectives regarding the role of endocannabinoid signalling in CHF and its potential as a target for pharmacological modulation...
  10. doi request reprint Altered myocardial expression of ghrelin and its receptor (GHSR-1a) in patients with severe heart failure
    Andres Beiras-Fernandez
    Department of Cardiac Surgery, Ludwig Maximilian University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Peptides 31:2222-8. 2010
    ..These findings may open up new perspectives regarding the potential of ghrelin signaling as a target for pharmacological modulation...
  11. ncbi request reprint MicroRNAs as potential therapeutic agents in the treatment of myocardial infarction
    Jens Heyn
    Department of Anaesthesiology, Ludwig Maximilians Universitat Munchen, Marchioninistrasse 15, D 81377 Munich, Germany
    Curr Vasc Pharmacol 9:733-40. 2011
    ....
  12. pmc Identification of valid endogenous control genes for determining gene expression in human glioma
    Simone Kreth
    Department of Neurosurgery, Ludwig Maximilians University Munich, Marchioninistr 15, 81377 Munich, Germany
    Neuro Oncol 12:570-9. 2010
    ....
  13. doi request reprint Epigenetics in human gliomas
    Simone Kreth
    Research Group of Molecular Medicine, Department of Anesthesiology, University of Munich LMU, Germany
    Cancer Lett 342:185-92. 2014
    ..We discuss diagnostic and therapeutic opportunities appearing at horizon of epigenetic research. Moreover, we present current and propose future clinical workflow models for molecular characterization of malignant gliomas...
  14. ncbi request reprint Experimental miRNA target validation
    Jens Heyn
    Clinic of Anesthesiology, Clinic of the University of Munich, Munich, Germany
    Methods Mol Biol 936:83-90. 2013
    ....
  15. doi request reprint Novel molecular stereotactic biopsy procedures reveal intratumoral homogeneity of loss of heterozygosity of 1p/19q and TP53 mutations in World Health Organization grade II gliomas
    Niklas Thon
    Department of Neurosurgery, Ludwig Maximilians University, Munich, Germany
    J Neuropathol Exp Neurol 68:1219-28. 2009
    ..There was no biopsy-related morbidity. We conclude that determination of the LOH 1p/19q and TP53 status using this molecular stereotactic biopsy technique is safe and reliable in cases of unresectable gliomas...
  16. pmc Motion sickness, stress and the endocannabinoid system
    Alexander Chouker
    Department of Anesthesiology, Ludwig Maximilians University, Munich, Germany
    PLoS ONE 5:e10752. 2010
    ..The endocannabinoid system (ECS) represents an important neuromodulator of stress and N&V. Inhibitory effects of the ECS on N&V are mediated by endocannabinoid-receptor activation...
  17. doi request reprint Immunomodulatory properties of pentoxifylline are mediated via adenosine-dependent pathways
    Simone Kreth
    Department of Anaesthesiology, Ludwig Maximilians University, Munich, Germany
    Shock 34:10-6. 2010
    ..Sufficient adenosine levels might be a prerequisite for the accessibility of sepsis patients to treatment with PTX...
  18. ncbi request reprint Ghrelin, a novel peptide hormone in the regulation of energy balance and cardiovascular function
    Carola Ledderose
    Department of Anesthesiology, Ludwig Maximilian University of Munich, Germany
    Recent Pat Endocr Metab Immune Drug Discov 5:1-6. 2011
    ....
  19. doi request reprint Huge intracardiac thrombosis in a patient on veno-arterial extracorporeal membrane oxygenation support
    Florian Weis
    Department of Anesthesiology, University Hospital Grosshadern, Ludwig Maximilians University, Munich, Germany
    Interact Cardiovasc Thorac Surg 8:247-9. 2009
    ..Following this the patient developed a nearly complete thrombosis of the left-sided cardiac chambers, despite successful laboratory anticoagulation...
  20. ncbi request reprint Setting up an intronic miRNA database
    Ludwig Christian Hinske
    Department of Anaesthesiology, Clinic of the University of Munich, Munich, Germany
    Methods Mol Biol 936:69-76. 2013
    ..We also provide an example of a simple, but useful analysis technique. The basic structures and ideas suggested in this chapter can easily be extended to integrating other data and be applied to different analysis techniques...
  21. doi request reprint Stress doses of hydrocortisone in high-risk patients undergoing cardiac surgery: effects on interleukin-6 to interleukin-10 ratio and early outcome
    Florian Weis
    Department of Anesthesiology, University of Munich, Klinikum Grosshadern, Munich, Germany
    Crit Care Med 37:1685-90. 2009
    ..Stress doses of hydrocortisone have been successfully used to improve outcome of CS. The interleukin (IL)-6 to IL-10 ratio is associated with outcome after trauma and major surgery...