Stefan G Kreft

Summary

Affiliation: University of Konstanz
Country: Germany

Publications

  1. pmc Split-Doa10: a naturally split polytopic eukaryotic membrane protein generated by fission of a nuclear gene
    Elisabeth Stuerner
    Department of Biology, University of Konstanz, Konstanz, Germany
    PLoS ONE 7:e45194. 2012
  2. pmc An unusual transmembrane helix in the endoplasmic reticulum ubiquitin ligase Doa10 modulates degradation of its cognate E2 enzyme
    Stefan G Kreft
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520 8114, USA
    J Biol Chem 286:20163-74. 2011
  3. pmc Aberrant substrate engagement of the ER translocon triggers degradation by the Hrd1 ubiquitin ligase
    Eric M Rubenstein
    Deptartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA
    J Cell Biol 197:761-73. 2012
  4. pmc Membrane and soluble substrates of the Doa10 ubiquitin ligase are degraded by distinct pathways
    Tommer Ravid
    Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA
    EMBO J 25:533-43. 2006
  5. ncbi request reprint Membrane topology of the yeast endoplasmic reticulum-localized ubiquitin ligase Doa10 and comparison with its human ortholog TEB4 (MARCH-VI)
    Stefan G Kreft
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520 8114, USA
    J Biol Chem 281:4646-53. 2006
  6. doi request reprint FAT10 and NUB1L bind to the VWA domain of Rpn10 and Rpn1 to enable proteasome-mediated proteolysis
    Neha Rani
    Division of Immunology, Department of Biology, University of Constance, 78457 Konstanz, Germany
    Nat Commun 3:749. 2012

Collaborators

Detail Information

Publications6

  1. pmc Split-Doa10: a naturally split polytopic eukaryotic membrane protein generated by fission of a nuclear gene
    Elisabeth Stuerner
    Department of Biology, University of Konstanz, Konstanz, Germany
    PLoS ONE 7:e45194. 2012
    ..Split-Doa10 is the first unequivocal case of a split membrane protein where fission occurred in a nuclear-encoded gene. Such a split may allow divergent functions for the individual protein segments...
  2. pmc An unusual transmembrane helix in the endoplasmic reticulum ubiquitin ligase Doa10 modulates degradation of its cognate E2 enzyme
    Stefan G Kreft
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520 8114, USA
    J Biol Chem 286:20163-74. 2011
    ..These results suggest that the TEB4-Doa10 domain regulates Doa10 association with the Ubc6 membrane anchor, thereby controlling the degradation rate of the E2...
  3. pmc Aberrant substrate engagement of the ER translocon triggers degradation by the Hrd1 ubiquitin ligase
    Eric M Rubenstein
    Deptartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA
    J Cell Biol 197:761-73. 2012
    ..Hrd1 therefore likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the translocon...
  4. pmc Membrane and soluble substrates of the Doa10 ubiquitin ligase are degraded by distinct pathways
    Tommer Ravid
    Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA
    EMBO J 25:533-43. 2006
    ..Thus, while Doa10 ubiquitinates both membrane and soluble proteins, the mechanisms of subsequent proteasome targeting differ...
  5. ncbi request reprint Membrane topology of the yeast endoplasmic reticulum-localized ubiquitin ligase Doa10 and comparison with its human ortholog TEB4 (MARCH-VI)
    Stefan G Kreft
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520 8114, USA
    J Biol Chem 281:4646-53. 2006
    ..Finally, we provide evidence that the likely human Doa10 ortholog, TEB4 (MARCH-VI), adopts a topology similar to that of Doa10...
  6. doi request reprint FAT10 and NUB1L bind to the VWA domain of Rpn10 and Rpn1 to enable proteasome-mediated proteolysis
    Neha Rani
    Division of Immunology, Department of Biology, University of Constance, 78457 Konstanz, Germany
    Nat Commun 3:749. 2012
    ..In conclusion, we identify the VWA domain of hRpn10 as a receptor for ubiquitin-like proteins within the 26S proteasome and elucidate how FAT10 mediates efficient proteolysis by the proteasome...