Christian P Kratz

Summary

Affiliation: University Hospital
Country: Germany

Publications

  1. ncbi Uniparental disomy at chromosome 11p15.5 followed by HRAS mutations in embryonal rhabdomyosarcoma: lessons from Costello syndrome
    Christian P Kratz
    Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University of Freiburg, Mathildenstrasse 1, 79106 Freiburg, Germany
    Hum Mol Genet 16:374-9. 2007
  2. pmc An unexpected new role of mutant Ras: perturbation of human embryonic development
    Christian P Kratz
    Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University of Freiburg, Mathildenstrasse 1, 79106, Freiburg, Germany
    J Mol Med (Berl) 85:227-35. 2007
  3. ncbi Germline mutations in components of the Ras signaling pathway in Noonan syndrome and related disorders
    Christian P Kratz
    Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany
    Cell Cycle 5:1607-11. 2006
  4. doi Craniosynostosis in patients with Noonan syndrome caused by germline KRAS mutations
    Christian P Kratz
    Department of Pediatrics, University of Freiburg, Freiburg, Germany
    Am J Med Genet A 149:1036-40. 2009
  5. ncbi Juvenile myelomonocytic leukemia
    Christian P Kratz
    Department of Pediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany
    Hematology 10:100-3. 2005
  6. ncbi Is granulocyte colony-stimulating factor therapy a risk factor for myelodysplasia/leukemia in patients with congenital neutropenia?
    Charlotte M Niemeyer
    Department of Pediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany
    Haematologica 90:2-3. 2005
  7. ncbi Essential versus reactive thrombocythemia in children: retrospective analyses of 12 cases
    Abeer Abd El-Moneim
    Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University of Freiburg, Germany
    Pediatr Blood Cancer 49:52-5. 2007
  8. ncbi Germline KRAS mutations cause Noonan syndrome
    Suzanne Schubbert
    Department of Pediatrics, University of California, 513 Parnassus Avenue, San Francisco, California 94143, USA
    Nat Genet 38:331-6. 2006
  9. pmc Myopathy caused by HRAS germline mutations: implications for disturbed myogenic differentiation in the presence of constitutive HRas activation
    Ineke van der Burgt
    J Med Genet 44:459-62. 2007
  10. pmc Expansion of the genotypic and phenotypic spectrum in patients with KRAS germline mutations
    Martin Zenker
    Institute of Human Genetics, University of Erlangen Nuremberg, Germany
    J Med Genet 44:131-5. 2007

Collaborators

Detail Information

Publications22

  1. ncbi Uniparental disomy at chromosome 11p15.5 followed by HRAS mutations in embryonal rhabdomyosarcoma: lessons from Costello syndrome
    Christian P Kratz
    Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University of Freiburg, Mathildenstrasse 1, 79106 Freiburg, Germany
    Hum Mol Genet 16:374-9. 2007
    ..These data implicate that in sporadic ERMS, UPD at 11p15.5 is not driven by HRAS mutations and that imbalances at 11p15.5 and HRAS mutations represent independent but cooperating events during ERMS development...
  2. pmc An unexpected new role of mutant Ras: perturbation of human embryonic development
    Christian P Kratz
    Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University of Freiburg, Mathildenstrasse 1, 79106, Freiburg, Germany
    J Mol Med (Berl) 85:227-35. 2007
    ....
  3. ncbi Germline mutations in components of the Ras signaling pathway in Noonan syndrome and related disorders
    Christian P Kratz
    Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany
    Cell Cycle 5:1607-11. 2006
    ..The discovery of germline mutations in this group of related genetic disorders underscores the pivotal role of the degree and duration of Ras activation in cell fate decisions during embryonic development and morphogenesis...
  4. doi Craniosynostosis in patients with Noonan syndrome caused by germline KRAS mutations
    Christian P Kratz
    Department of Pediatrics, University of Freiburg, Freiburg, Germany
    Am J Med Genet A 149:1036-40. 2009
    ....
  5. ncbi Juvenile myelomonocytic leukemia
    Christian P Kratz
    Department of Pediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany
    Hematology 10:100-3. 2005
  6. ncbi Is granulocyte colony-stimulating factor therapy a risk factor for myelodysplasia/leukemia in patients with congenital neutropenia?
    Charlotte M Niemeyer
    Department of Pediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany
    Haematologica 90:2-3. 2005
  7. ncbi Essential versus reactive thrombocythemia in children: retrospective analyses of 12 cases
    Abeer Abd El-Moneim
    Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University of Freiburg, Germany
    Pediatr Blood Cancer 49:52-5. 2007
    ..Essential thrombocythemia (ET) rarely occurs in the pediatric population and little is known about the clinical course and the molecular characteristics...
  8. ncbi Germline KRAS mutations cause Noonan syndrome
    Suzanne Schubbert
    Department of Pediatrics, University of California, 513 Parnassus Avenue, San Francisco, California 94143, USA
    Nat Genet 38:331-6. 2006
    ..These studies establish germline KRAS mutations as a cause of human disease and infer that the constellation of developmental abnormalities seen in Noonan syndrome spectrum is, in large part, due to hyperactive Ras...
  9. pmc Myopathy caused by HRAS germline mutations: implications for disturbed myogenic differentiation in the presence of constitutive HRas activation
    Ineke van der Burgt
    J Med Genet 44:459-62. 2007
    ....
  10. pmc Expansion of the genotypic and phenotypic spectrum in patients with KRAS germline mutations
    Martin Zenker
    Institute of Human Genetics, University of Erlangen Nuremberg, Germany
    J Med Genet 44:131-5. 2007
    ..Germline mutations in KRAS have recently been identified in a small number of patients with Noonan syndrome and CFC...
  11. pmc Biochemical and functional characterization of germ line KRAS mutations
    Suzanne Schubbert
    Department of Pediatrics, University of California, 513 Parnassus Avenue, HSE 302, San Francisco, California 94143, USA
    Mol Cell Biol 27:7765-70. 2007
    ....
  12. pmc The mutational spectrum of PTPN11 in juvenile myelomonocytic leukemia and Noonan syndrome/myeloproliferative disease
    Christian P Kratz
    University of California, Room HSE 302 Box 0519, San Francisco, CA 94143, USA
    Blood 106:2183-5. 2005
    ..This supports the need to characterize the spectrum of hematologic abnormalities in individuals with NS and to better define the impact of the PTPN11 lesion on the disease course in patients with NS/MPD and JMML...
  13. ncbi How a rare pediatric neoplasia can give important insights into biological concepts: a perspective on juvenile myelomonocytic leukemia
    Christian Flotho
    Haematologica 92:1441-6. 2007
  14. ncbi Mutation analysis of the BRAF oncogene in juvenile myelomonocytic leukemia
    Andrica C H De Vries
    Haematologica 92:1574-5. 2007
    ..B-Raf plays a central role in this pathway. In 65 screened JMML patients we identified no BRAF mutations and we conclude that this gene is unlikely to play a role in the pathogenesis of JMML...
  15. doi Genotype-phenotype correlation in cases of juvenile myelomonocytic leukemia with clonal RAS mutations
    Christian Flotho
    Blood 111:966-7; author reply 967-8. 2008
  16. pmc SOS1 is the second most common Noonan gene but plays no major role in cardio-facio-cutaneous syndrome
    Martin Zenker
    J Med Genet 44:651-6. 2007
    ..Mutations of SOS1, the gene encoding a guanine nucleotide exchange factor for Ras, have been the most recent discoveries in patients with NS, but this gene has not been studied in patients with CFCS...
  17. ncbi JAK2 mutations other than V617F: a novel mutation and mini review
    Axel Karow
    Leuk Res 32:365-6. 2008
  18. ncbi MLL5, a homolog of Drosophila trithorax located within a segment of chromosome band 7q22 implicated in myeloid leukemia
    Brooke M Emerling
    Department of Pediatrics and Comprehensive Cancer Center, University of California, San Francisco, California, CA 94143, USA
    Oncogene 21:4849-54. 2002
    ..MLL5 is a novel mammalian Trx-G gene that might modulate transcription by protein association...
  19. ncbi Evans syndrome in a patient with chromosome 22q11.2 deletion syndrome: a case report
    Christian P Kratz
    Department of Pediatric Hematology and Oncology, Heinrich Heine University, Dusseldorf, Germany
    Pediatr Hematol Oncol 20:167-72. 2003
    ..The patient reported herein strengthens the association between the 22q11.2 deletion spectrum and Evans syndrome...
  20. ncbi Mutation analysis of CUTL1 in childhood myeloid neoplasias with monosomy 7
    Simone Hindersin
    Leuk Res 31:1323-4. 2007
  21. ncbi TERC mutations in children with refractory cytopenia
    Christina A Ortmann
    Haematologica 91:707-8. 2006
    ..Here, we screened for TERC mutations in a cohort of 80 children with hypocellular myelodysplastic syndrome and detected TERC alterations in two of them...
  22. ncbi Genomic structure of the PIK3CG gene on chromosome band 7q22 and evaluation as a candidate myeloid tumor suppressor
    Christian P Kratz
    Department of Pediatrics, University of California, San Francisco 94143, USA
    Blood 99:372-4. 2002
    ..This allele was also detected in unaffected parents and in 1 of 60 control alleles; it probably represents a polymorphism. PIK3CG is unlikely to act as a recessive TSG in myeloid leukemias with monosomy 7...