Johannes Kornhuber

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. doi Functional Inhibitors of Acid Sphingomyelinase (FIASMAs)
    Johannes Kornhuber
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen, Schwabachanlage 6, D 91054, Erlangen, Germany
    Handb Exp Pharmacol 215:169-86. 2013
  2. pmc Qualitative prediction of blood-brain barrier permeability on a large and refined dataset
    Markus Muehlbacher
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Erlangen Nuremberg, Germany
    J Comput Aided Mol Des 25:1095-106. 2011
  3. pmc Statistical methods for detecting and comparing periodic data and their application to the nycthemeral rhythm of bodily harm: A population based study
    Armin M Stroebel
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    J Circadian Rhythms 8:10. 2010
  4. pmc Non-pharmacological, multicomponent group therapy in patients with degenerative dementia: a 12-month randomizied, controlled trial
    Elmar Graessel
    Department of Medical Psychology and Medical Sociology, Friedrich Alexander Universitat Erlangen Nurnberg, Clinic for Psychiatry and Psychotherapy, Schwabachanlage 6, 91054 Erlangen, Germany
    BMC Med 9:129. 2011
  5. pmc Identification of novel functional inhibitors of acid sphingomyelinase
    Johannes Kornhuber
    Department of Psychiatry and Psychotherapy, University of Erlangen, Erlangen, Germany
    PLoS ONE 6:e23852. 2011
  6. pmc Low digit ratio 2D:4D in alcohol dependent patients
    Johannes Kornhuber
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    PLoS ONE 6:e19332. 2011
  7. doi Early and differential diagnosis of dementia and mild cognitive impairment: design and cohort baseline characteristics of the German Dementia Competence Network
    Johannes Kornhuber
    Department of Psychiatry and Psychotherapy, University Erlangen, Erlangen, Germany
    Dement Geriatr Cogn Disord 27:404-17. 2009
  8. doi Lipophilic cationic drugs increase the permeability of lysosomal membranes in a cell culture system
    Johannes Kornhuber
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    J Cell Physiol 224:152-64. 2010
  9. doi Functional Inhibitors of Acid Sphingomyelinase (FIASMAs): a novel pharmacological group of drugs with broad clinical applications
    Johannes Kornhuber
    Department of Psychiatry and Psychotherapy, University of Erlangen, Erlangen, Germany
    Cell Physiol Biochem 26:9-20. 2010
  10. ncbi Memantine pharmacotherapy: a naturalistic study using a population pharmacokinetic approach
    Johannes Kornhuber
    Department of Psychiatry and Psychotherapy, University of Erlangen, Erlangen, Germany
    Clin Pharmacokinet 46:599-612. 2007

Collaborators

Detail Information

Publications128 found, 100 shown here

  1. doi Functional Inhibitors of Acid Sphingomyelinase (FIASMAs)
    Johannes Kornhuber
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen, Schwabachanlage 6, D 91054, Erlangen, Germany
    Handb Exp Pharmacol 215:169-86. 2013
    ..We describe the structural and physicochemical properties, the distribution, the pharmacokinetics, the pharmocodynamics and the clinical use of direct and functional inhibitors of the acid sphingomyelinase...
  2. pmc Qualitative prediction of blood-brain barrier permeability on a large and refined dataset
    Markus Muehlbacher
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Erlangen Nuremberg, Germany
    J Comput Aided Mol Des 25:1095-106. 2011
    ..A random forest prediction system (n(trees) = 5) based on only four descriptors yields a validated accuracy of 88%...
  3. pmc Statistical methods for detecting and comparing periodic data and their application to the nycthemeral rhythm of bodily harm: A population based study
    Armin M Stroebel
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    J Circadian Rhythms 8:10. 2010
    ..Animals, including humans, exhibit a variety of biological rhythms. This article describes a method for the detection and simultaneous comparison of multiple nycthemeral rhythms...
  4. pmc Non-pharmacological, multicomponent group therapy in patients with degenerative dementia: a 12-month randomizied, controlled trial
    Elmar Graessel
    Department of Medical Psychology and Medical Sociology, Friedrich Alexander Universitat Erlangen Nurnberg, Clinic for Psychiatry and Psychotherapy, Schwabachanlage 6, 91054 Erlangen, Germany
    BMC Med 9:129. 2011
    ....
  5. pmc Identification of novel functional inhibitors of acid sphingomyelinase
    Johannes Kornhuber
    Department of Psychiatry and Psychotherapy, University of Erlangen, Erlangen, Germany
    PLoS ONE 6:e23852. 2011
    ..Virtual screening revealed that only six out of 768 (0.78%) compounds of natural products functionally inhibit ASM, whereas this inhibitory activity occurs in 135 out of 2028 (6.66%) drugs licensed for medical use in humans...
  6. pmc Low digit ratio 2D:4D in alcohol dependent patients
    Johannes Kornhuber
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    PLoS ONE 6:e19332. 2011
    ..723). These findings provide novel insights into the role of prenatal androgen exposure in the development of alcohol dependency and for the use of 2D∶4D as a possible trait marker in identifying patients with alcohol dependency...
  7. doi Early and differential diagnosis of dementia and mild cognitive impairment: design and cohort baseline characteristics of the German Dementia Competence Network
    Johannes Kornhuber
    Department of Psychiatry and Psychotherapy, University Erlangen, Erlangen, Germany
    Dement Geriatr Cogn Disord 27:404-17. 2009
    ..The German Dementia Competence Network (DCN) has established procedures for standardized multicenter acquisition of clinical, biological and imaging data, for centralized data management, and for the evaluation of new treatments...
  8. doi Lipophilic cationic drugs increase the permeability of lysosomal membranes in a cell culture system
    Johannes Kornhuber
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    J Cell Physiol 224:152-64. 2010
    ..Manipulation of lysosomal membrane permeability might be useful to overcome, for example, multi-drug resistance by altering subcellular drug distribution...
  9. doi Functional Inhibitors of Acid Sphingomyelinase (FIASMAs): a novel pharmacological group of drugs with broad clinical applications
    Johannes Kornhuber
    Department of Psychiatry and Psychotherapy, University of Erlangen, Erlangen, Germany
    Cell Physiol Biochem 26:9-20. 2010
    ..Most of the available FIASMAs are licensed for medical use in humans, are minimally toxic and may therefore be applied for disease states associated with increased activity of ASM...
  10. ncbi Memantine pharmacotherapy: a naturalistic study using a population pharmacokinetic approach
    Johannes Kornhuber
    Department of Psychiatry and Psychotherapy, University of Erlangen, Erlangen, Germany
    Clin Pharmacokinet 46:599-612. 2007
    ..The objective of the present study was, therefore, to investigate the reasons for the observed variability of the pharmacokinetics of memantine in a representative patient population and to explore patient covariates on drug disposition...
  11. ncbi Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model
    Johannes Kornhuber
    Department of Psychiatry and Psychotherapy, University of Erlangen, Germany
    J Med Chem 51:219-37. 2008
    ..During the course of the study, we characterized 26 new functional ASM inhibitors, including doxepine 63, fluoxetine 104, maprotiline 109, nortriptyline 114, paroxetine 118, sertraline 124, suloctidil 125, and terfenadine 127...
  12. doi Molecular properties of psychopharmacological drugs determining non-competitive inhibition of 5-HT3A receptors
    Johannes Kornhuber
    Department of Psychiatry and Psychotherapy, University of Erlangen, Schwabachanlage 6, D 91054 Erlangen, Germany
    Eur J Med Chem 44:2667-72. 2009
    ..A low mu/MW is compatible with drug-cumulation in apolar lipid rafts. This study confirms that size-intensive descriptors allow the development of compact SPAR models...
  13. doi The role of ceramide in major depressive disorder
    Johannes Kornhuber
    Department of Psychiatry and Psychotherapy, University of Erlangen, Schwabachanlage 6, 91054 Erlangen, Germany
    Eur Arch Psychiatry Clin Neurosci 259:S199-204. 2009
    ..The ASM/ceramide pathway might be a missing link unifying independent findings in neurobiology and the treatment of MDD such as therapeutic latency, oxidative stress, immune activation and increased risk of cardiovascular disease...
  14. doi Use-dependent inhibition of synaptic transmission by the secretion of intravesicularly accumulated antipsychotic drugs
    Carsten H Tischbirek
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nurnberg, Erlangen, Germany
    Neuron 74:830-44. 2012
    ..Taken together, these results indicate that accumulated antipsychotic drugs recycle with synaptic vesicles and have a use-dependent, autoinhibitory effect on synaptic transmission...
  15. ncbi Apolipoprotein E4 genotype is not associated with short-term cognition deficits during alcohol withdrawal
    Julia Wilhelm
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Alcohol 37:151-6. 2005
    ....
  16. ncbi Apolipoprotein E gene polymorphism and previous alcohol withdrawal seizures
    Julia Wilhelm
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    J Psychiatr Res 41:871-5. 2007
    ..Our findings suggest an association between the apolipoprotein E3 gene variant and an elevated risk of alcohol withdrawal seizures. These preliminary results must be validated in further studies...
  17. ncbi Multiplexed quantification of dementia biomarkers in the CSF of patients with early dementias and MCI: a multicenter study
    Piotr Lewczuk
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Neurobiol Aging 29:812-8. 2008
    ..9 pg/mL. These cutoff values were also applied to discriminate between MCI-AD and MCI-O subjects. Simultaneous measurement of the biomarkers significantly improves management of the samples and quality control of the assays' performance...
  18. ncbi Spontaneous magnetoencephalographic activity in patients with obsessive-compulsive disorder
    Christian Maihofner
    Department of Neurology, Friedrich Alexander University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Brain Res 1129:200-5. 2007
    ..Therefore, we provide further functional neuroimaging evidence that the complex features of OCD have neural correlates, which may help in a future understanding of this disease...
  19. doi Association of V89L SRD5A2 polymorphism with craving and serum leptin levels in male alcohol addicts
    Bernd Lenz
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Schwabachanlage 6 10, 91054 Erlangen, Germany
    Psychopharmacology (Berl) 224:421-9. 2012
    ..The steroid 5-α reductase 2 (SRD5A2) converts testosterone to dihydrotestosterone and thereby causes increased androgenic potency...
  20. doi Hippocampal volume differences between healthy young apolipoprotein E ε2 and ε4 carriers
    Panagiotis Alexopoulos
    Department of Psychiatry and Psychotherapy, Klinikum der Friedrich Alexander Universität Erlangen Nürnberg, Erlangen, Germany
    J Alzheimers Dis 26:207-10. 2011
    ..The difference in hippocampal morphology is cognitively/clinically silent in young adulthood, but could render APOE ε4 carriers more prone to the later development of AD possibly due to lower reserve cognitive capacity...
  21. doi N-methyl-D-aspartate 2b receptor subtype (NR2B) promoter methylation in patients during alcohol withdrawal
    Teresa Biermann
    Department of Psychiatry and Psychotherapy, University Hospital of Erlangen, Erlangen, Germany
    J Neural Transm 116:615-22. 2009
    ..55; P = 0.013; daily ethanol intake: rho = -0.46; P = 0.043). These findings might explain the observation of an impact of alcohol consumption patterns on the gravity of withdrawal symptoms...
  22. doi The TTTAn aromatase (CYP19A1) polymorphism is associated with compulsive craving of male patients during alcohol withdrawal
    Bernd Lenz
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Psychoneuroendocrinology 36:1261-4. 2011
    ..Future investigations should enrol women and consider sex hormone levels for further clarification of the observed TTTAn-craving relationship...
  23. doi ERK1/2 protein and mRNA levels in human blood are linked to smoking behavior
    Bernd Lenz
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Germany
    Addict Biol 17:1026-35. 2012
    ....
  24. ncbi Different allele-distribution of mthfr 677 C -> T and mthfr -393 C -> a in patients classified according to subtypes of Lesch's typology
    Dominikus Bönsch
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Schwabachanlage 6 91054 Erlangen, Germany
    Alcohol Alcohol 41:364-7. 2006
    ..2 (SD 8.9) years) were classified according to LT and divided into four groups: LT 1 (n = 26), LT 2 (n = 65), LT 3 (n = 58), and LT 4 (n = 18). Total plasma homocysteine levels and MTHFR genotypes -393, 677, and 1,793 were determined...
  25. doi Alpha-synuclein mRNA levels correspond to beck depression inventory scores in females with eating disorders
    Helge Frieling
    Department of Psychiatry and Psychotherapy, University Erlangen Nuremberg, Erlangen, Germany
    Neuropsychobiology 58:48-52. 2008
    ..Further investigations in patients with depression as a sole diagnosis are needed to support its role in the pathogenesis of major depression...
  26. doi Epigenetic downregulation of atrial natriuretic peptide but not vasopressin mRNA expression in females with eating disorders is related to impulsivity
    Helge Frieling
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Neuropsychopharmacology 33:2605-9. 2008
    ..ANP mRNA expression was inversely associated with impaired impulse regulation. We conclude that epigenetic mechanisms may contribute to the known alterations of ANP homeostasis in women with eating disorders...
  27. doi Elevated cannabinoid 1 receptor mRNA is linked to eating disorder related behavior and attitudes in females with eating disorders
    Helge Frieling
    Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Germany
    Psychoneuroendocrinology 34:620-4. 2009
    ..The endocannabinoid system is involved in the regulation of appetite, food intake and energy balance...
  28. doi Elevation of homocysteine levels is only partially reversed after therapy in females with eating disorders
    Julia Wilhelm
    Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Erlangen, Germany
    J Neural Transm 117:521-7. 2010
    ..These findings add further evidence to the hypothesis that homocysteine might be involved in the pathophysiology of anorexia and bulimia nervosa...
  29. doi Sex hormone activity in alcohol addiction: integrating organizational and activational effects
    Bernd Lenz
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Germany
    Prog Neurobiol 96:136-63. 2012
    ..The early sex hormone activity model of alcohol addiction may prove to be a valuable tool in the development of preventive and therapeutic strategies...
  30. ncbi Amyloid beta peptide ratio 42/40 but not A beta 42 correlates with phospho-Tau in patients with low- and high-CSF A beta 40 load
    Jens Wiltfang
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    J Neurochem 101:1053-9. 2007
    ..We conclude that the amyloid beta concentration ratio should replace the 'raw' concentrations of corresponding A beta peptides to improve reliability of the neurochemical dementia diagnosis...
  31. ncbi Tau protein phosphorylated at threonine 181 in CSF as a neurochemical biomarker in Alzheimer's disease: original data and review of the literature
    Piotr Lewczuk
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    J Mol Neurosci 23:115-22. 2004
    ..The current literature regarding the physiological and pathological role of phosphorylated Tau proteins is reviewed, as well as the role of these proteins as promising biomarkers in the diagnosis of neurodegenerative disorders...
  32. ncbi International quality control survey of neurochemical dementia diagnostics
    Piotr Lewczuk
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Neurosci Lett 409:1-4. 2006
    ..Although the results of this quality control survey are promising, the quality of measurements has to be further optimized...
  33. ncbi An assessment of the potential value of elevated homocysteine in predicting alcohol-withdrawal seizures
    Stefan Bleich
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Epilepsia 47:934-8. 2006
    ..The aim of the present study was to calculate the best predictive cutoff value of plasma homocysteine levels in actively drinking alcoholics (n = 88) with first-onset alcohol-withdrawal seizures...
  34. doi Smoking behaviour is associated with expression and phosphorylation of CREB in human buffy coat
    Bernd Lenz
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Germany
    Int J Neuropsychopharmacol 13:207-15. 2010
    ..This kind of study may be helpful for translating findings from animal models and cell cultures...
  35. ncbi Elevated prolactin serum levels and history of alcohol withdrawal seizures
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Germany
    J Psychiatr Res 41:702-6. 2007
    ..Prolactin has been discussed to be useful for differential diagnosis in epilepsia. Aim of the present study was to investigate the association between prolactin serum levels and previous alcohol withdrawal seizures...
  36. doi Adherence-dependent shifts in the patterns of beta-amyloid peptides secreted by human mononuclear phagocytes
    Juan Manuel Maler
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Brain Behav Immun 22:1044-8. 2008
    ..Thus, mononuclear phagocytes might be one source of the N-truncated Abeta peptides regularly found in human plasma and are less likely to contribute substantially to plasma Abeta(1-42)...
  37. doi Epigenetic regulation and gene expression of vasopressin and atrial natriuretic peptide in alcohol withdrawal
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Germany
    Psychoneuroendocrinology 34:555-60. 2009
    ..Further studies focusing on longitudinal changes of epigenetic regulation and gene expression of both peptides are needed to clarify the pathophysiological role of these findings...
  38. doi Distinct fractional Abeta release patterns in human mononuclear phagocytes
    Juan Manuel Maler
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    J Neuroimmunol 206:1-4. 2009
    ..MNP derived from early AD patients released significantly more total Abeta peptides than age-matched controls. The proportion of Abeta(1-42) was not altered...
  39. doi Polymorphism of the long polyglutamine tract in the human androgen receptor influences craving of men in alcohol withdrawal
    Bernd Lenz
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Schwabachanlage 6 10, D 91054 Erlangen, Germany
    Psychoneuroendocrinology 34:968-71. 2009
    ..In summary, the presented data points to an underestimated role of the genetic regulation of androgens in the pathogenesis of alcohol dependence and related disorders...
  40. doi Increased levels of adiponectin and resistin in alcohol dependence--possible link to craving
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Germany
    Drug Alcohol Depend 99:333-7. 2009
    ..Furthermore, adiponectin may be involved in the neurobiology of alcohol craving, possibly via its effects on the hypothalamic circuits...
  41. doi Promoter specific methylation of the dopamine transporter gene is altered in alcohol dependence and associated with craving
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    J Psychiatr Res 43:388-92. 2009
    ..Furthermore, hypermethylation of the DAT-promoter may play an important role in dopaminergic neurotransmission and is associated with decreased alcohol craving...
  42. pmc Systematic heterogeneity of fractional vesicle pool sizes and release rates of hippocampal synapses
    Oliver Welzel
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Biophys J 100:593-601. 2011
    ..This observation could be explained by assigning the rate-limiting factor for vesicle exocytosis at high frequency stimulation to the available active zone surface that is proportionally smaller in synapses with larger volumes...
  43. ncbi Depressive symptoms may explain elevated plasma levels of homocysteine in females with eating disorders
    Helge Frieling
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlagen, Germany
    J Psychiatr Res 42:83-6. 2008
    ..8; df = 42; P = 0.008). Presence of depressive symptoms may explain elevated homocysteine levels previously reported in patients with eating disorders or vice versa. Longitudinal studies are needed to unravel this hen or egg problem...
  44. ncbi Alpha-synuclein protein levels are increased in alcoholic patients and are linked to craving
    Dominikus Bönsch
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Alcohol Clin Exp Res 29:763-5. 2005
    ..The aim of the current study was to investigate whether protein levels of alpha synuclein in alcoholics are changed and possibly influence alcohol craving...
  45. ncbi Volume intake and craving in alcohol withdrawal
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Alcohol Alcohol 41:61-5. 2006
    ..The present study was undertaken to evaluate whether the daily volume intake of alcoholic beverages is associated with craving in patients undergoing alcohol withdrawal...
  46. ncbi Urea-based two-dimensional electrophoresis of beta-amyloid peptides in human plasma: evidence for novel Abeta species
    Juan Manuel Maler
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Proteomics 7:3815-20. 2007
    ..It might further help identifying plasma Abeta species suitable as biomarkers for the diagnosis of Alzheimer's disease (AD)...
  47. ncbi Memantine inhibits ethanol-induced NMDA receptor up-regulation in rat hippocampal neurons
    Juan Manuel Maler
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Germany
    Brain Res 1052:156-62. 2005
    ..These results may provide a molecular explanation for beneficial effects of memantine on ethanol-induced glutamatergic hyperexcitability reflected in the ethanol withdrawal syndrome and on the development of ethanol dependence...
  48. doi CB1 and CB2 receptor expression and promoter methylation in patients with cannabis dependence
    Andrea Rotter
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Eur Addict Res 19:13-20. 2013
    ..023; T = -2.3; p = 0.023) and the WHO-Assist Subscale for Cannabis consumption (r = -0.068; T = -2.4; p = 0.02). CB1 receptor expression levels and methylation status appear to be altered in subjects with THC dependence...
  49. doi Activity of secretory sphingomyelinase is increased in plasma of alcohol-dependent patients
    Martin Reichel
    Department of Psychiatry and Psychotherapy, University Hospital, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Alcohol Clin Exp Res 35:1852-9. 2011
    ..However, the influence of ethanol on secretory ASM (S-ASM) has not been investigated so far...
  50. doi Increased acid sphingomyelinase activity in peripheral blood cells of acutely intoxicated patients with alcohol dependence
    Martin Reichel
    Department of Psychiatry and Psychotherapy, University of Erlangen, Erlangen, Germany
    Alcohol Clin Exp Res 34:46-50. 2010
    ..Ethanol-induced activation of ASM has been observed in different cell culture systems, thus raising the question about the effect of alcohol intoxication in human subjects on ASM activity in vivo...
  51. doi Repetitive transcranial magnetic stimulation influences mood in healthy male volunteers
    Gerd Schaller
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Schwabachanlage 6 10, D 91054 Erlangen, Germany
    J Psychiatr Res 45:1178-83. 2011
    ..0111) immediately after stimulation. Our data show that a 9-day long series of HF-rTMS of the left DLPFC improves mood, analysed by BDI in healthy young men, whereas no significant long-term changes were found in VAS...
  52. doi Fluoxetine prevents stimulation-dependent fatigue of synaptic vesicle exocytosis in hippocampal neurons
    Andreas Wolfram Henkel
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    J Neurochem 114:697-705. 2010
    ..These observations support the idea that therapeutic concentrations of fluoxetine enhance the recovery of neurotransmission from exhausting stimuli in healthy and in hyperosmotically stressed neurons as well...
  53. doi Emotional reactivity to odors: olfactory sensitivity and the span of emotional evaluation separate the genders
    Norbert Thuerauf
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Neurosci Lett 456:74-9. 2009
    ..Investigating olfactory sensitivity females detected n-butanol and discriminated the 16 odors of the test significantly better than males. These results indicate that females possess higher olfactory sensitivity...
  54. ncbi Evidence of an association of leptin serum levels and craving in alcohol dependence
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Psychoneuroendocrinology 32:87-90. 2007
    ..160, t=5.793, p<0.001) with a power of 1.00. In contrast to previous results describing an association only in female patients, this power-based analysis shows that leptin is associated with alcohol craving in both genders...
  55. doi Epigenetic dysregulation of dopaminergic genes in eating disorders
    Helge Frieling
    Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Erlangen, Germany
    Int J Eat Disord 43:577-83. 2010
    ....
  56. doi Measurement of ERK 1/2 in CSF from patients with neuropsychiatric disorders and evidence for the presence of the activated form
    Hans Wolfgang Klafki
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    J Alzheimers Dis 18:613-22. 2009
    ....
  57. ncbi Role of appetite-regulating peptides in alcohol craving: an analysis in respect to subtypes and different consumption patterns in alcoholism
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Erlangen, Germany
    Alcohol Clin Exp Res 31:950-4. 2007
    ..Aim of this analysis was to search for differences regarding an association between these peptides and alcohol craving with respect to different subtypes and beverage consumption patterns in patients with alcohol dependence...
  58. ncbi Ghrelin levels are increased in alcoholism
    Thomas Kraus
    Department of Psychiatry and Psychotherapy, University Hospital, Erlangen, Germany
    Alcohol Clin Exp Res 29:2154-7. 2005
    ..Therefore, the aim of the present pilot study was to determine whether the gut-derived peptide ghrelin which increases hunger and food intake is altered and associated with alcohol craving in alcoholic patients..
  59. doi Intrathecal IgG synthesis in patients with alterations in the neurochemical dementia diagnostics
    Rüdiger Zimmermann
    Department of Psychiatry and Psychotherapy, Universitatsklinikum Erlangen, Erlangen, Germany
    J Alzheimers Dis 19:1199-203. 2010
    ..This, in turn, suggests that extended diagnosis should be performed in patients with "isolated" alterations of NDD biomarkers or intrathecal immunoglobulin synthesis...
  60. pmc Phagocytosis and LPS alter the maturation state of β-amyloid precursor protein and induce different Aβ peptide release signatures in human mononuclear phagocytes
    Philipp Spitzer
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    J Neuroinflammation 7:59. 2010
    ..Similarly, cerebrovascular β-amyloid (Aβ) deposits are surrounded by perivascular macrophages. Both observations indicate a contribution of the mononuclear phagocyte system to the development of β-amyloid...
  61. pmc Antidepressant drugs modulate growth factors in cultured cells
    Andreas W Henkel
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    BMC Pharmacol 8:6. 2008
    ..In this study, antidepressant treatments are analyzed in a cell culture system, to study the modulation of growth factors...
  62. doi NACP-Rep1 relates to Beck Depression Inventory scores in healthy humans
    Bernd Lenz
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Schwabachanlage 6 10, 91054 Erlangen, Germany
    J Mol Neurosci 44:41-7. 2011
    ..The reported results may contribute to a better understanding of the molecular mechanisms linked to depressive symptoms...
  63. doi NGF plasma levels increase due to alcohol intoxication and decrease during withdrawal
    Annemarie Heberlein
    Department of Psychiatry and Psychotherapy, University Hospital Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Psychoneuroendocrinology 33:999-1003. 2008
    ..These results suggest that NGF plasma levels increase as part of a regulation mechanism that counteracts alcohol intoxication...
  64. doi Influence of brain-derived neurotrophic-factor and apolipoprotein E genetic variants on hippocampal volume and memory performance in healthy young adults
    Tanja Richter-Schmidinger
    Department of Psychiatry and Psychotherapy, Friedrich Alexander Universitat Erlangen Nurnberg, Erlangen, Germany
    J Neural Transm 118:249-57. 2011
    ..BDNF Val66Met polymorphism seems to influence working memory function and modulate the effects of ageing on working memory in healthy young adults...
  65. ncbi Prolactin serum levels and alcohol craving - an analysis using Lesch's typology
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Neuropsychobiology 53:133-6. 2006
    ..Prolactin secretion is closely connected to dopaminergic transmission that is known to play a crucial role in mediating reinforcement and craving in alcoholism...
  66. ncbi Neurochemical diagnosis of Alzheimer's dementia by CSF Abeta42, Abeta42/Abeta40 ratio and total tau
    Piotr Lewczuk
    Molecular Neurobiology Lab, Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Neurobiol Aging 25:273-81. 2004
    ..Presence of the apolipoprotein E 4 allele, age or degree of mental disability did not significantly influence the parameters studied...
  67. ncbi Alcoholism and homicide with respect to the classification systems of Lesch and Cloninger
    Udo Reulbach
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg Germany Schwabachanlage 6, 91054 Erlangen, Germany
    Alcohol Alcohol 42:103-7. 2007
    ..A psychopathological subtyping of alcohol dependence in offenders who committed homicide has mainly been related to impulsive and dissocial personalities up to now...
  68. ncbi Influence of beer, wine and spirits consumption on craving
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Germany
    Addict Biol 10:181-6. 2005
    ..In addition, it is an important predictor for both obsessive and compulsive craving. Further studies are needed to clarify the pathophysiological basis of this finding...
  69. ncbi Evidence of increased homocysteine levels in alcoholism: the Franconian alcoholism research studies (FARS)
    Stefan Bleich
    Friedrich Alexander University of Erlangen Nuremberg, Department of Psychiatry and Psychotherapy, Schwabachanlage 6, 91054 Erlangen, Germany
    Alcohol Clin Exp Res 29:334-6. 2005
    ..Therefore, this power analysis-based study was undertaken to determine whether plasma homocysteine levels are evidently altered in actively drinking alcoholic patients and patients with early abstinence...
  70. doi Orexin A expression and promoter methylation in patients with alcohol dependence comparing acute and protracted withdrawal
    Kristina Bayerlein
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University Erlangen Nuremberg, Germany
    Alcohol 45:541-7. 2011
    ..Orexin A may be a possible candidate to further elucidate mechanisms of alcohol withdrawal taking into account energy homoeostasis in the circuit of reward and motivation...
  71. ncbi Plasma homocysteine concentrations do not influence craving in alcohol withdrawal
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Alcohol 34:211-5. 2004
    ..Therefore, further research about alcohol craving should focus on neurobiologic factors other than homocysteine...
  72. doi The relation of regional cerebral perfusion and atrophy in mild cognitive impairment (MCI) and early Alzheimer's dementia
    Christian Luckhaus
    Department of Psychiatry and Psychotherapy, Heinrich Heine University, Duesseldorf, Germany
    Psychiatry Res 183:44-51. 2010
    ..The data also support the concept of functional compensatory brain activation and the diaschisis hypothesis as relevant in incipient and early AD...
  73. doi Hippocampal volume loss in patients with alcoholism is influenced by the consumed type of alcoholic beverage
    Julia Wilhelm
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, D 91054 Erlangen, Germany
    Alcohol Alcohol 43:296-9. 2008
    ..Aim of the present study was to investigate different types of alcoholic beverages with regard to hippocampal volume loss in patients suffering from alcoholism...
  74. ncbi Homocysteine regulates expression of Herp by DNA methylation involving the AARE and CREB binding sites
    Bernd Lenz
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Germany
    Exp Cell Res 312:4049-55. 2006
    ..Complete methylation of the CpG islands resulted in suppressed gene expression...
  75. ncbi Electrophoretic separation of amyloid beta peptides in plasma
    Piotr Lewczuk
    Department of Psychiatry and Psychotherapy, Molecular Neurobiology Lab, University of Erlangen Nuernberg, Erlangen, Germany
    Electrophoresis 25:3336-43. 2004
    ..Our method can be used to investigate the significance of plasma Abeta peptides in neurodegenerative disorders, and to monitor the efficiency of drugs with beta/gamma-secretase inhibitory potency...
  76. ncbi Nicotine dependence is associated with compulsive alcohol craving
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Germany
    Addiction 101:892-7. 2006
    ..To investigate a possible association of nicotine dependence and alcohol craving...
  77. ncbi Homocysteine levels in patients classified according to Lesch's typology
    Stefan Bleich
    Friedrich Alexander, University of Erlangen Nuremberg, Department of Psychiatry and Psychotherapy, Schwabachanlage 6, D 91054 Erlangen, Germany
    Alcohol Alcohol 39:493-8. 2004
    ..Patients were classified in Lesch's typology (LT) and were divided into two groups: LT 1 (n = 27) and LT 2-4 (n = 117). Within the groups, patients with or without a history of alcohol withdrawal seizures were differentiated...
  78. ncbi Specific and unspecific auditory hallucinations in patients with schizophrenia: a magnetoencephalographic study
    Udo Reulbach
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Erlangen Nuremberg, Germany
    Neuropsychobiology 55:89-95. 2007
    ..Auditory verbal hallucinations are thought to arise from a disorder of inner speech, but little is known about their origin...
  79. ncbi Pharmacokinetic characterization of amantadine in human brain tissue
    Johannes Kornhuber
    Department of Psychiatry and Psychotherapy, University of Erlangen, Germany
    Ther Drug Monit 28:693-5. 2006
    ..The elimination half-life of amantadine from brain tissue is much longer than from blood and is comparable to the previously investigated neuroleptic drugs haloperidol and levomepromazine...
  80. ncbi Combinations of carbohydrate-deficient transferrin, mean corpuscular erythrocyte volume, gamma-glutamyltransferase, homocysteine and folate increase the significance of biological markers in alcohol dependent patients
    Daniela Rinck
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Germany
    Drug Alcohol Depend 89:60-5. 2007
    ..This study focuses on the combination of established laboratory parameters with new meaningful biomarkers to advance the significance regarding alcohol dependence...
  81. ncbi DNA hypermethylation of the alpha synuclein promoter in patients with alcoholism
    Dominikus Bönsch
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Schwabachanlage 6 10, D 91054 Erlangen, Germany
    Neuroreport 16:167-70. 2005
    ....
  82. ncbi The amyloid-beta (Abeta) peptide pattern in cerebrospinal fluid in Alzheimer's disease: evidence of a novel carboxyterminally elongated Abeta peptide
    Piotr Lewczuk
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Rapid Commun Mass Spectrom 17:1291-6. 2003
    ..We conclude that SELDI-TOF offers a promising tool for dementia expression pattern profiling using a minute amount of a biological sample...
  83. ncbi Epigenetic DNA hypermethylation of the HERP gene promoter induces down-regulation of its mRNA expression in patients with alcohol dependence
    Stefan Bleich
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Alcohol Clin Exp Res 30:587-91. 2006
    ....
  84. ncbi Particularities of suicide in the elderly. A population-based study
    Teresa Biermann
    Department of Psychiatry and Psychotherapy, University Hospital of Erlangen, D 91054 Erlangen, Germany
    Aging Clin Exp Res 21:470-4. 2009
    ..Suicide in later life stages is of growing concern as the life expectancy of Western populations is rising. Therefore, a population- based study concerning elderly suicide was undertaken...
  85. doi Nuclear medicine diagnostic techniques in the era of pathophysiology-based CSF biomarkers for Alzheimer's disease
    Markus Weih
    Department for Psychiatry and Psychiatry, University of Erlangen Nurenberg, Erlangen, Germany
    J Alzheimers Dis 26:97-103. 2011
    ..In the current review, we describe recent advances in AD biomarkers as well as improvements in the SPECT technique...
  86. doi Neurochemical dementia diagnostics in Alzheimer's disease: where are we now and where are we going?
    Piotr Lewczuk
    Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen and Friedrich Alexander Universität Erlangen Nürnberg, Germany
    Expert Rev Proteomics 8:447-58. 2011
    ..This article presents the state-of-the-art in the field of cerebrospinal fluid-based NDD, and also summarizes some of the hypotheses of how the future development of NDD tools might look...
  87. doi A fast and robust method for automated analysis of axonal transport
    Oliver Welzel
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Eur Biophys J 40:1061-9. 2011
    ..The present work enables the quantification of axonal transport parameters with high throughput with no a priori assumptions and minimal human intervention...
  88. doi Neurochemical dementia diagnostics: assays in CSF and blood
    Piotr Lewczuk
    Department of Psychiatry and Psychotherapy, Universitatsklinikum Erlangen, Schwabachanlage 6, Erlangen, Germany
    Eur Arch Psychiatry Clin Neurosci 258:44-9. 2008
    ..Although lumbar puncture is a mildly invasive procedure with a low incidence of complications, establishing blood assays capable of reliably measuring NDD biomarkers is an aim of several studies worldwide...
  89. doi Is tinnitus an acoasm?
    Wolfgang Sperling
    Department of Psychiatry and Psychotherapy, University Hospital of Erlangen, Friedrich Alexander University of Erlangen Nuremberg, Germany
    Med Hypotheses 77:216-9. 2011
    ..It is even speculated that both clinical entities might profit from treatment strategies that are normally employed for treatment of the other...
  90. doi Assaults in the elderly--a population-based study with victim and perpetrator characteristics
    Teresa Biermann
    Department of Psychiatry and Psychotherapy, University Hospital of Erlangen, Schwabachanlage 6, D 91054 Erlangen, Germany
    J Forensic Sci 56:669-73. 2011
    ..1% vs. 68.8%) and were victimized significantly more in rural areas (p < 0.001; 41.2% vs. 30.2%). Violence in the elderly differs from that of the younger population. Further research is warranted to establish prevention measures...
  91. ncbi Recurrent hyponatremia under desmopressin overdosing: is abuse a possible explication?
    Thomas Hillemacher
    Department of Psychiatry and Psychotherapy, University Hospital Erlangen, D 91054 Erlangen, Germany
    Am J Emerg Med 25:239-40. 2007
  92. ncbi Neuroendocrine pathways in benzodiazepine dependence: new targets for research and therapy
    Annemarie Heberlein
    Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Germany
    Hum Psychopharmacol 23:171-81. 2008
    ..Depending on the available results possible implications of NPY and CCK on benzodiazepine addiction and withdrawal symptoms are reviewed, thereby providing topics for further research...
  93. doi Unsuitable readability levels of patient information pertaining to dementia and related diseases: a comparative analysis
    Markus Weih
    Department of Psychiatry and Psychotherapy, University Erlangen Nuremberg, Erlangen, Germany
    Int Psychogeriatr 20:1116-23. 2008
    ..Our study investigated the readability of printed material about dementia that is offered to patients and caregivers...
  94. doi [The internet as an information source for family caregivers of dementia patients]
    Elmar Grassel
    Die Institutsangaben sind am Ende des Beitrags gelistet
    Psychiatr Prax 36:115-8. 2009
    ..What significance has the Internet as a source of information for family caregivers of dementia patients?..
  95. doi The hypothesis of an impact of ozone on the occurrence of completed and attempted suicides
    Teresa Biermann
    Department of Psychiatry and Psychotherapy, University Hospital of Erlangen, Schwabachanlage 6, D 91054 Erlangen, Germany
    Med Hypotheses 72:338-41. 2009
    ..If this hypothesis is found to be true, further research should focus on the underlying mechanisms. Furthermore, this might be a strong argument to further encourage environment protection...
  96. doi Olfactory lateralization: odor intensity but not the hedonic estimation is lateralized
    Norbert Thuerauf
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Neurosci Lett 438:228-32. 2008
    ..For odor identification, however, a statistical tendency was observed. Based on our results we concluded that olfactory intensity estimates represent the most sensitive parameter of olfactory lateralization...
  97. ncbi Daily variations of homocysteine concentration may influence methylation of DNA in normal healthy individuals
    Dominikus Bönsch
    Department of Psychiatry and Psychotherapy, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Chronobiol Int 24:315-26. 2007
    ..001). Males showed higher overall homocysteine levels compared to females (p=0.002). Genomic DNA methylation showed a significant rhythm with increased levels at night (p=0.021), which was inverse to plasma homocysteine levels...
  98. doi Neurochemical dementia diagnostics: a simple algorithm for interpretation of the CSF biomarkers
    Piotr Lewczuk
    Department of Psychiatry and Psychotherapy, Universitatsklinikum Erlangen, Erlangen, Germany
    J Neural Transm 116:1163-7. 2009
    ....
  99. doi To sweat or not to sweat? A hypothesis on the effects of venlafaxine and SSRIs
    Joachim Demling
    Department of Psychiatry and Psychotherapy, Universitatsklinikum Erlangen, Schwabachanlage 6, 91054 Erlangen, Germany
    Med Hypotheses 74:155-7. 2010
    ..At daily doses of up to 75 mg venlafaxine, sweating is largely avoided as a concomitant effect...
  100. doi Differences and similarities on neuronal activities of people being happily and unhappily in love: a functional magnetic resonance imaging study
    Christina Stoessel
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Neuropsychobiology 64:52-60. 2011
    ....
  101. ncbi Amyloid beta peptides in cerebrospinal fluid as profiled with surface enhanced laser desorption/ionization time-of-flight mass spectrometry: evidence of novel biomarkers in Alzheimer's disease
    Piotr Lewczuk
    Department of Psychiatry and Psychotherapy PL, TWG, JMM, JK, JW, University of Erlangen Nuremberg, Erlangen, Germany
    Biol Psychiatry 55:524-30. 2004
    ..The advent of new therapeutic avenues for Alzheimer's disease (AD) calls for an improved early and differential diagnosis...