Genomes and Genes
Hans Christian Kornau
Affiliation: University of Hamburg
- GABA(B) receptors and synaptic modulationHans Christian Kornau
Center for Molecular Neurobiology ZMNH, University of Hamburg, Falkenried 94, 20251 Hamburg, Germany
Cell Tissue Res 326:517-33. 2006..This review summarizes our knowledge of the localization, structure and function of GABA(B) receptors in the central nervous system and their use as drug targets for neurological and psychiatric disorders...
- GABAB receptor constituents revealed by tandem affinity purification from transgenic miceTudor Bartoi
Center for Molecular Neurobiology ZMNH, University of Hamburg, Falkenried 94, D 20251 Hamburg, Germany
J Biol Chem 285:20625-33. 2010..The mice equipped with tags on GABA(B1) facilitate validation and identification of native binding partners of GABA(B) receptors, providing insight into the molecular mechanisms of synaptic modulation...
- AMPA receptor signaling through BRAG2 and Arf6 critical for long-term synaptic depressionRalf Scholz
Center for Molecular Neurobiology ZMNH, University of Hamburg, Hamburg, Germany
Neuron 66:768-80. 2010..We conclude that BRAG2-mediated Arf6 activation triggered by AMPA receptors is the convergent step of different forms of LTD, thus providing an essential mechanism for the control of vesicle formation by endocytic cargo...
- GABA(B) receptor subunit 1 binds to proteins affected in 22q11 deletion syndromeDagmar Zunner
Center for Molecular Neurobiology, University of Hamburg, Germany
Biochem Biophys Res Commun 393:185-9. 2010..Thus, sequential coiled-coil interactions may direct GABA(B1) into functional receptors...
- Importance of the gamma-aminobutyric acid(B) receptor C-termini for G-protein couplingSylvia Grünewald
Axaron Bioscience AG, Heidelberg, Germany
Mol Pharmacol 61:1070-80. 2002..Thus, the C-terminal conformation of the GABA(B) receptor may determine its constitutive activity, which could be a therapeutic target for inverse agonists...