Research Topics
Genomes and Genes
| Heike KolschSummaryAffiliation: University of Bonn Country: Germany Publications
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Detail Information
Publications
The role of 24S-hydroxycholesterol in Alzheimer's diseaseH Kolsch
Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53127 Bonn, Germany
J Nutr Health Aging 7:37-41. 2003..This review will give a brief overview on the relevance of 24S-hydroxycholesterol as a possible risk factor and diagnostic state marker for AD...
CYP46A1 variants influence Alzheimer's disease risk and brain cholesterol metabolismHeike Kolsch
Department of Psychiatry, University of Bonn, Germany
Eur Psychiatry 24:183-90. 2009..Only few gene variations in CYP46 gene (CYP46A1) have been investigated for their relevance as genetic risk factors of Alzheimer's disease (AD) and results are contradictory...- Association of SORL1 gene variants with Alzheimer's diseaseHeike Kolsch
Department of Psychiatry, University of Bonn, Bonn, Germany
Brain Res 1264:1-6. 2009..Thus, our data support a role of SORL1 polymorphisms in AD... - RXRA gene variations influence Alzheimer's disease risk and cholesterol metabolismHeike Kolsch
Department of Psychiatry, University of Bonn, Bonn, Germany
J Cell Mol Med 13:589-98. 2009..009, plasma: P= 0.002; TGC haplotype: CSF: P= 0.019, plasma: P= 0.005). Our results suggest that RXRA gene variants might act as risk factor for AD via an influence on cerebral cholesterol metabolism... - Polymorphism in ABCA1 influences CSF 24S-hydroxycholesterol levels but is not a major risk factor of Alzheimer's diseaseHeike Kolsch
Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
Int J Mol Med 17:791-4. 2006..Our data support the observation that ABCA1 polymorphisms influence cholesterol metabolism of the brain, but might not act as a major risk factor in AD... - Gene polymorphisms in prodynorphin (PDYN) are associated with episodic memory in the elderlyHeike Kolsch
Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, Bonn 53105, Germany
J Neural Transm 116:897-903. 2009..Verbal fluency scores were non-significantly better in carriers of these respective alleles. Thus, our results suggest a role of PDYN gene variations in determining memory function also in elderly humans... - Influence of SORL1 gene variants: association with CSF amyloid-beta products in probable Alzheimer's diseaseHeike Kolsch
Department of Psychiatry, University of Bonn, Bonn, Germany
Neurosci Lett 440:68-71. 2008..15). We found a SORL1 haplotype which was associated with CSF levels of amyloid-beta cleavage products, measured as altered levels of Abeta42. Thus our data suggest that SORL1 gene variants might influence AD pathology... - ACE I/D polymorphism is a risk factor of Alzheimer's disease but not of vascular dementiaH Kolsch
Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Neurosci Lett 377:37-9. 2005..Cell-specific effects of ACE polymorphism are suggested, additional studies on neuronal cells might help to understand the role of this polymorphism in AD... - Polymorphisms in glutathione S-transferase omega-1 and AD, vascular dementia, and strokeH Kolsch
Department of Psychiatry, University of Bonn, Germany
Neurology 63:2255-60. 2004..Polymorphisms in GSTO1 might influence the function of the protein and thus the risk of AD, VaD, and stroke... - Putative association of polymorphism in the mannose 6-phosphate receptor gene with major depression and Alzheimer's diseaseHeike Kolsch
Department of Psychiatry, University of Bonn, Germany
Psychiatr Genet 14:97-100. 2004..Since exploratory data suggest an involvement of the endosomal lysosomal system in major depression, further studies are warranted to investigate the biological role of the CD-MPR in major depression... - Association of the C766T polymorphism of the low-density lipoprotein receptor-related protein gene with Alzheimer's diseaseHeike Kolsch
Department of Psychiatry, University of Bonn, Bonn, Germany
Am J Med Genet B Neuropsychiatr Genet 121:128-30. 2003..Further research on LRP polymorphisms is needed to evaluate their effects on the risk of AD, on coronary artery disease and on longevity... - Neuroprotective effects of estradiol-17beta: implications for psychiatric disordersH Kolsch
Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
Arch Womens Ment Health 5:105-10. 2002.... - Contribution of apolipoprotein E and cathepsin D genotypes to the familial aggregation of Alzheimer's diseaseReinhard Heun
Department of Psychiatry, University of Bonn, Bonn, Germany
Dement Geriatr Cogn Disord 18:151-8. 2004..The familial aggregation of late-onset Alzheimer's disease (AD) might be caused by the clustering of genetic risk factors in families. This study investigates the influence of variants of candidate genes on the familial aggregation of AD... - SREBP-1a polymorphism influences the risk of Alzheimer's disease in carriers of the ApoE4 alleleChristian Spell
Department of Psychiatry, University of Bonn, Bonn, Germany
Dement Geriatr Cogn Disord 18:245-9. 2004..This is the first report on a genetic factor which prevents the deleterious effect of the ApoE4 allele and thus reduces the risk of AD... - Homocysteine metabolism and cerebrospinal fluid markers for Alzheimer's diseaseJulius Popp
Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
J Alzheimers Dis 18:819-28. 2009..The results suggest that alteration of the homocysteine metabolism is related to increased accumulation of phosphorylated tau and may contribute to the neurofibrillary pathology in normal aging and in AD... - CETP polymorphisms influence cholesterol metabolism but not Alzheimer's disease riskHomeira Qureischie
Department of Psychiatry, University of Bonn, Sigmund Freud Strabetae 25, 53105 Bonn, Germany
Brain Res 1232:1-6. 2008..Our data suggest that CETP gene variations influence cerebral and peripheral cholesterol metabolism, but not AD risk... - Association of polymorphism in the transcription factor LBP-1c/CP2/LSF gene with Alzheimer's disease and major depressionSchamim Schahab
Department of Psychiatry, University of Bonn, Bonn, Germany
Dement Geriatr Cogn Disord 22:95-8. 2006..These data suggest the presence of a putative risk gene for major depression at chromosome 12... - Patterns of subjective memory impairment in the elderly: association with memory performanceFrank Jessen
Department of Psychiatry, University of Bonn, Bonn, Germany
Psychol Med 37:1753-62. 2007..However, SMI is also a predictor for future dementia. Thus, there is a need to identify subtypes of SMI that are particularly related to inferior memory performance and may represent at-risk stages for cognitive decline... - Cerebrospinal fluid markers for Alzheimer's disease over the lifespan: effects of age and the APOEε4 genotypeJulius Popp
Department of Psychiatry, University of Bonn, Bonn, Germany
J Alzheimers Dis 22:459-68. 2010..They also suggest that the decrease of Aβ1-42, but not the increase of pTau181 CSF levels is accelerated by the APOEε4 genotype in middle-aged and older adults with normal cognition... - Prediction of dementia by subjective memory impairment: effects of severity and temporal association with cognitive impairmentFrank Jessen
Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Arch Gen Psychiatry 67:414-22. 2010..Subjective memory impairment (SMI) is receiving increasing attention as a pre-mild cognitive impairment (MCI) condition in the course of the clinical manifestation of Alzheimer disease (AD)... - Polymorphism in the cholesterol 24S-hydroxylase gene is associated with Alzheimer's diseaseHeike Kolsch
Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Mol Psychiatry 7:899-902. 2002..Our results indicate that the CYP46 gene locus may predispose to AD by increasing the 24S-hydroxycholesterol/cholesterol ratio in the brain... - APOA1 polymorphism influences risk for early-onset nonfamiliar ADHeike Vollbach
Department of Psychiatry, University of Bonn, Bonn, Germany
Ann Neurol 58:436-41. 2005..No influence of the +83/84bp polymorphism on the risk for AD was observed. These results suggest that variants of APOA1 might influence the onset and the risk for AD... - Investigation of a genetic variation of a variable number tandem repeat polymorphism of interleukin-6 gene in patients with multiple sclerosisStephan Schmidt
Dept of Neurology, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
J Neurol 250:607-11. 2003..Taken together, a disease-modifying effect of IL-6 C allele could not be demonstrated in MS patients of German Caucasian descent... 
Emotion-induced retrograde amnesia varies as a function of noradrenergic-glucocorticoid activityRene Hurlemann
Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53105, Bonn, Germany
Psychopharmacology (Berl) 194:261-9. 2007..This peri-emotional amnesia is amygdala-dependent and varies as a function of norepinephrine activity. However, less is known about the amnesiogenic potential of cortisol...- Alterations of cholesterol precursor levels in Alzheimer's diseaseHeike Kolsch
Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
Biochim Biophys Acta 1801:945-50. 2010..These findings raise doubt on a beneficial effect of cholesterol lowering treatment in manifest AD... - CSF cortisol in Alzheimer's disease and mild cognitive impairmentJulius Popp
Department of Psychiatry, University of Bonn, Bonn, Germany
Neurobiol Aging 30:498-500. 2009..001) and to MCI subjects (p=0.002). There was no significant increase of cortisol in MCI subjects compared with controls suggesting that the increase of CSF cortisol is not an early event in the course of AD... - Association of an interleukin-1beta gene polymorphism at position -511 with Alzheimer's diseaseChristian Ehl
Department of Psychiatry, University of Bonn, D 53105 Bonn, Germany
Int J Mol Med 11:235-8. 2003..Even though IL-1beta -511 polymorphism did not influence the risk of AD it might have a pathophysiological influence on the disease process... - Polymorphism in the BACE gene influences the risk for Alzheimer's diseaseChartika M Kirschling
Department of Psychiatry, University of Bonn, Germany
Neuroreport 14:1243-6. 2003..Furthermore, Abeta(42) CSF levels were influenced by BACE genotype. It appears that BACE polymorphism plays a more important role in the development of AD than previously assumed, possibly by influencing Abeta(42) levels... - Association of the PPARgamma gene polymorphism Pro12Ala with delayed onset of multiple sclerosisLuisa Klotz
Department of Neurology, University of Bonn, Germany
Neurosci Lett 449:81-3. 2009..Our population-based study demonstrates that the Pro12Ala polymorphism resulting in an amino acid exchange in the N-terminal sequence of PPARgamma may influence the onset of MS... - PPARD haplotype influences cholesterol metabolism but is no risk factor of Alzheimer's diseaseJulia Holzapfel
Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Neurosci Lett 408:57-61. 2006..8+/-7.7ng/mg; non-carriers: 58.6+/-2.3ng/mg; p=0.002) but not in non-demented controls. Our results suggest that PPARD haplotypes might influence levels of cholesterol metabolites in AD patients, but act not as risk factors of AD... - Risk factors and early signs of Alzheimer's disease in a family study sample. Risk of ADReinhard Heun
Department of Psychiatry, University of Bonn, Venusberg, 53105 Bonn, Germany
Eur Arch Psychiatry Clin Neurosci 256:28-36. 2006.... - Cathepsin D: screening for new polymorphisms using single-strand conformation polymorphism analysisMicael Majores
Department of Psychiatry, University of Bonn, D 53105 Bonn, Germany
Int J Mol Med 9:185-7. 2002..Thus, if sequence variations within the CTSD gene influence the risk for various diseases, the pathogenic mechanism is likely to be linked to the amino acid substitution in the profragment of CTSD... - The power of sample size and homogenous sampling: association between the 5-HTTLPR serotonin transporter polymorphism and major depressive disorderBarbara Hoefgen
Department of Psychiatry, University of Bonn, Germany
Biol Psychiatry 57:247-51. 2005..Consistently replicated evidence for an involvement of this polymorphism in the etiology of mood disorders, particularly in major depressive disorder (MDD), remains scant... - Cholesterol metabolism is associated with soluble amyloid precursor protein production in Alzheimer's diseaseJulius Popp
Department of Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland
J Neurochem 123:310-6. 2012..Furthermore, plasma 27-OHC concentrations were associated with the CSF sAPP levels. The results suggest that high CSF concentrations of cholesterol, 24S-OHC, and 27-OHC are associated with increased production of both sAPP forms in AD... - The methionine synthase polymorphism c.2756Aright curved arrow G (D919G) is relevant for disease-free longevityMichael Linnebank
Department of Neurology, University Hospital Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
Int J Mol Med 16:759-61. 2005..Separate analysis of female and male subjects revealed that the influence of the MTR genotype on male subjects became relevant at a younger age as opposed to female subjects suggesting a gender-dependent effect... - Multicentre variability of MRI-based medial temporal lobe volumetry in Alzheimer's diseaseStefan J Teipel
Department of Psychiatry, University Rostock, Rostock, Germany
Psychiatry Res 182:244-50. 2010..Our data indicate that multicentre acquisition of MRI data using manual volumetry is reliable and feasible for cross-sectional diagnostic studies, and they replicate essential findings from smaller scale monocentre studies... - Interaction of insulin and PPAR-α genes in Alzheimer's disease: the Epistasis ProjectHeike Kolsch
Department of Psychiatry, University of Bonn, Bonn, Germany
J Neural Transm 119:473-9. 2012..We suggest that dysregulation of glucose metabolism contributes to the development of AD and might be due in part to genetic variations in INS and PPARA and their interaction especially in Northern Europeans... - Genetic variations and humoral immune responses to myelin oligodendroglia glycoprotein in adult phenotypes of X-linked adrenoleukodystrophyStephan Schmidt
Department of Neurology, University of Bonn, Sigmund Freud Str 20, 53105, Bonn, Germany
J Neuroimmunol 135:148-53. 2003..Anti-MOG antibodies were detectable in 17/54 X-ALD patients (31.5%). Anti-MOG antibodies were associated with the 226 bp (TAAA)(n) MOG gene polymorphism but not with distinct clinical phenotypes... - Macrophage migration inhibitory factor in mild cognitive impairment and Alzheimer's diseaseJulius Popp
University of Bonn, Department of Psychiatry, Bonn, Germany
J Psychiatr Res 43:749-53. 2009..407; p=0.023). These results demonstrate increased MIF production in AD and MCI suggesting that MIF may be involved in the occurring neuroinflammatory process at a clinical pre-dementia disease stage... - Homocysteine and carotid intima-media thickness in a german population: lack of clinical relevanceMichael Linnebank
Department of Neurology, University Hospital Bonn, Bonn, Germany
Stroke 37:2840-2. 2006..Common carotid artery intima-media thickness (CCA IMT) is a predictor of stroke. This study aimed to analyze whether homocysteine (Hcys) metabolism influences CCA IMT... - Glucose metabolism, gray matter structure, and memory decline in subjective memory impairmentLukas Scheef
Department of Radiology, University of Bonn, Bonn, Germany
Neurology 79:1332-9. 2012..To identify biological evidence for Alzheimer disease (AD) in individuals with subjective memory impairment (SMI) and unimpaired cognitive performance and to investigate the longitudinal cognitive course in these subjects... - VKORC1-dependent pharmacokinetics of intravenous and oral phylloquinone (vitamin K1) mixed micelles formulationMilka Marinova
Institute of Experimental Hematology and Transfusion Medicine, University Clinics Bonn, Sigmund Freud Strasse 25, 53127 Bonn, Germany
Eur J Clin Pharmacol 69:467-75. 2013..The subjects were allocated to one of three genotype-specific groups (n = 10 in each group) in terms of VKORC1 promoter polymorphism c.-1639 G > A to explore the relationship between genotype and pharmacokinetic parameters... - Noradrenergic modulation of emotion-induced forgetting and rememberingRene Hurlemann
Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
J Neurosci 25:6343-9. 2005..We conclude that a differential processing of emotional arousal and valence influences how the brain remembers and forgets...