Heike Kolsch

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. ncbi request reprint The role of 24S-hydroxycholesterol in Alzheimer's disease
    H Kolsch
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53127 Bonn, Germany
    J Nutr Health Aging 7:37-41. 2003
  2. ncbi request reprint ACE I/D polymorphism is a risk factor of Alzheimer's disease but not of vascular dementia
    H Kolsch
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Neurosci Lett 377:37-9. 2005
  3. ncbi request reprint Influence of SORL1 gene variants: association with CSF amyloid-beta products in probable Alzheimer's disease
    Heike Kolsch
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Neurosci Lett 440:68-71. 2008
  4. ncbi request reprint Polymorphisms in glutathione S-transferase omega-1 and AD, vascular dementia, and stroke
    H Kolsch
    Department of Psychiatry, University of Bonn, Germany
    Neurology 63:2255-60. 2004
  5. doi request reprint CYP46A1 variants influence Alzheimer's disease risk and brain cholesterol metabolism
    Heike Kolsch
    Department of Psychiatry, University of Bonn, Germany
    Eur Psychiatry 24:183-90. 2009
  6. ncbi request reprint Putative association of polymorphism in the mannose 6-phosphate receptor gene with major depression and Alzheimer's disease
    Heike Kolsch
    Department of Psychiatry, University of Bonn, Germany
    Psychiatr Genet 14:97-100. 2004
  7. ncbi request reprint Association of the C766T polymorphism of the low-density lipoprotein receptor-related protein gene with Alzheimer's disease
    Heike Kolsch
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Am J Med Genet B Neuropsychiatr Genet 121:128-30. 2003
  8. doi request reprint Association of SORL1 gene variants with Alzheimer's disease
    Heike Kolsch
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Brain Res 1264:1-6. 2009
  9. doi request reprint RXRA gene variations influence Alzheimer's disease risk and cholesterol metabolism
    Heike Kolsch
    Department of Psychiatry, University of Bonn, Bonn, Germany
    J Cell Mol Med 13:589-98. 2009
  10. ncbi request reprint Polymorphism in ABCA1 influences CSF 24S-hydroxycholesterol levels but is not a major risk factor of Alzheimer's disease
    Heike Kolsch
    Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
    Int J Mol Med 17:791-4. 2006

Collaborators

Detail Information

Publications44

  1. ncbi request reprint The role of 24S-hydroxycholesterol in Alzheimer's disease
    H Kolsch
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53127 Bonn, Germany
    J Nutr Health Aging 7:37-41. 2003
    ..This review will give a brief overview on the relevance of 24S-hydroxycholesterol as a possible risk factor and diagnostic state marker for AD...
  2. ncbi request reprint ACE I/D polymorphism is a risk factor of Alzheimer's disease but not of vascular dementia
    H Kolsch
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Neurosci Lett 377:37-9. 2005
    ..Cell-specific effects of ACE polymorphism are suggested, additional studies on neuronal cells might help to understand the role of this polymorphism in AD...
  3. ncbi request reprint Influence of SORL1 gene variants: association with CSF amyloid-beta products in probable Alzheimer's disease
    Heike Kolsch
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Neurosci Lett 440:68-71. 2008
    ..15). We found a SORL1 haplotype which was associated with CSF levels of amyloid-beta cleavage products, measured as altered levels of Abeta42. Thus our data suggest that SORL1 gene variants might influence AD pathology...
  4. ncbi request reprint Polymorphisms in glutathione S-transferase omega-1 and AD, vascular dementia, and stroke
    H Kolsch
    Department of Psychiatry, University of Bonn, Germany
    Neurology 63:2255-60. 2004
    ..Polymorphisms in GSTO1 might influence the function of the protein and thus the risk of AD, VaD, and stroke...
  5. doi request reprint CYP46A1 variants influence Alzheimer's disease risk and brain cholesterol metabolism
    Heike Kolsch
    Department of Psychiatry, University of Bonn, Germany
    Eur Psychiatry 24:183-90. 2009
    ..Only few gene variations in CYP46 gene (CYP46A1) have been investigated for their relevance as genetic risk factors of Alzheimer's disease (AD) and results are contradictory...
  6. ncbi request reprint Putative association of polymorphism in the mannose 6-phosphate receptor gene with major depression and Alzheimer's disease
    Heike Kolsch
    Department of Psychiatry, University of Bonn, Germany
    Psychiatr Genet 14:97-100. 2004
    ..Since exploratory data suggest an involvement of the endosomal lysosomal system in major depression, further studies are warranted to investigate the biological role of the CD-MPR in major depression...
  7. ncbi request reprint Association of the C766T polymorphism of the low-density lipoprotein receptor-related protein gene with Alzheimer's disease
    Heike Kolsch
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Am J Med Genet B Neuropsychiatr Genet 121:128-30. 2003
    ..Further research on LRP polymorphisms is needed to evaluate their effects on the risk of AD, on coronary artery disease and on longevity...
  8. doi request reprint Association of SORL1 gene variants with Alzheimer's disease
    Heike Kolsch
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Brain Res 1264:1-6. 2009
    ..Thus, our data support a role of SORL1 polymorphisms in AD...
  9. doi request reprint RXRA gene variations influence Alzheimer's disease risk and cholesterol metabolism
    Heike Kolsch
    Department of Psychiatry, University of Bonn, Bonn, Germany
    J Cell Mol Med 13:589-98. 2009
    ..009, plasma: P= 0.002; TGC haplotype: CSF: P= 0.019, plasma: P= 0.005). Our results suggest that RXRA gene variants might act as risk factor for AD via an influence on cerebral cholesterol metabolism...
  10. ncbi request reprint Polymorphism in ABCA1 influences CSF 24S-hydroxycholesterol levels but is not a major risk factor of Alzheimer's disease
    Heike Kolsch
    Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
    Int J Mol Med 17:791-4. 2006
    ..Our data support the observation that ABCA1 polymorphisms influence cholesterol metabolism of the brain, but might not act as a major risk factor in AD...
  11. ncbi request reprint Neuroprotective effects of estradiol-17beta: implications for psychiatric disorders
    H Kolsch
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    Arch Womens Ment Health 5:105-10. 2002
    ....
  12. doi request reprint Gene polymorphisms in prodynorphin (PDYN) are associated with episodic memory in the elderly
    Heike Kolsch
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, Bonn 53105, Germany
    J Neural Transm 116:897-903. 2009
    ..Verbal fluency scores were non-significantly better in carriers of these respective alleles. Thus, our results suggest a role of PDYN gene variations in determining memory function also in elderly humans...
  13. ncbi request reprint Contribution of apolipoprotein E and cathepsin D genotypes to the familial aggregation of Alzheimer's disease
    Reinhard Heun
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Dement Geriatr Cogn Disord 18:151-8. 2004
    ..The familial aggregation of late-onset Alzheimer's disease (AD) might be caused by the clustering of genetic risk factors in families. This study investigates the influence of variants of candidate genes on the familial aggregation of AD...
  14. ncbi request reprint SREBP-1a polymorphism influences the risk of Alzheimer's disease in carriers of the ApoE4 allele
    Christian Spell
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Dement Geriatr Cogn Disord 18:245-9. 2004
    ..This is the first report on a genetic factor which prevents the deleterious effect of the ApoE4 allele and thus reduces the risk of AD...
  15. doi request reprint Homocysteine metabolism and cerebrospinal fluid markers for Alzheimer's disease
    Julius Popp
    Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
    J Alzheimers Dis 18:819-28. 2009
    ..The results suggest that alteration of the homocysteine metabolism is related to increased accumulation of phosphorylated tau and may contribute to the neurofibrillary pathology in normal aging and in AD...
  16. doi request reprint CETP polymorphisms influence cholesterol metabolism but not Alzheimer's disease risk
    Homeira Qureischie
    Department of Psychiatry, University of Bonn, Sigmund Freud Strabetae 25, 53105 Bonn, Germany
    Brain Res 1232:1-6. 2008
    ..Our data suggest that CETP gene variations influence cerebral and peripheral cholesterol metabolism, but not AD risk...
  17. ncbi request reprint Association of polymorphism in the transcription factor LBP-1c/CP2/LSF gene with Alzheimer's disease and major depression
    Schamim Schahab
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Dement Geriatr Cogn Disord 22:95-8. 2006
    ..These data suggest the presence of a putative risk gene for major depression at chromosome 12...
  18. ncbi request reprint Patterns of subjective memory impairment in the elderly: association with memory performance
    Frank Jessen
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Psychol Med 37:1753-62. 2007
    ..However, SMI is also a predictor for future dementia. Thus, there is a need to identify subtypes of SMI that are particularly related to inferior memory performance and may represent at-risk stages for cognitive decline...
  19. doi request reprint Cerebrospinal fluid markers for Alzheimer's disease over the lifespan: effects of age and the APOEε4 genotype
    Julius Popp
    Department of Psychiatry, University of Bonn, Bonn, Germany
    J Alzheimers Dis 22:459-68. 2010
    ..They also suggest that the decrease of Aβ1-42, but not the increase of pTau181 CSF levels is accelerated by the APOEε4 genotype in middle-aged and older adults with normal cognition...
  20. doi request reprint Prediction of dementia by subjective memory impairment: effects of severity and temporal association with cognitive impairment
    Frank Jessen
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Arch Gen Psychiatry 67:414-22. 2010
    ..Subjective memory impairment (SMI) is receiving increasing attention as a pre-mild cognitive impairment (MCI) condition in the course of the clinical manifestation of Alzheimer disease (AD)...
  21. ncbi request reprint Polymorphism in the cholesterol 24S-hydroxylase gene is associated with Alzheimer's disease
    Heike Kolsch
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Mol Psychiatry 7:899-902. 2002
    ..Our results indicate that the CYP46 gene locus may predispose to AD by increasing the 24S-hydroxycholesterol/cholesterol ratio in the brain...
  22. ncbi request reprint Investigation of a genetic variation of a variable number tandem repeat polymorphism of interleukin-6 gene in patients with multiple sclerosis
    Stephan Schmidt
    Dept of Neurology, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    J Neurol 250:607-11. 2003
    ..Taken together, a disease-modifying effect of IL-6 C allele could not be demonstrated in MS patients of German Caucasian descent...
  23. ncbi request reprint APOA1 polymorphism influences risk for early-onset nonfamiliar AD
    Heike Vollbach
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Ann Neurol 58:436-41. 2005
    ..No influence of the +83/84bp polymorphism on the risk for AD was observed. These results suggest that variants of APOA1 might influence the onset and the risk for AD...
  24. pmc Emotion-induced retrograde amnesia varies as a function of noradrenergic-glucocorticoid activity
    Rene Hurlemann
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53105, Bonn, Germany
    Psychopharmacology (Berl) 194:261-9. 2007
    ..This peri-emotional amnesia is amygdala-dependent and varies as a function of norepinephrine activity. However, less is known about the amnesiogenic potential of cortisol...
  25. doi request reprint Alterations of cholesterol precursor levels in Alzheimer's disease
    Heike Kolsch
    Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
    Biochim Biophys Acta 1801:945-50. 2010
    ..These findings raise doubt on a beneficial effect of cholesterol lowering treatment in manifest AD...
  26. ncbi request reprint CSF cortisol in Alzheimer's disease and mild cognitive impairment
    Julius Popp
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Neurobiol Aging 30:498-500. 2009
    ..001) and to MCI subjects (p=0.002). There was no significant increase of cortisol in MCI subjects compared with controls suggesting that the increase of CSF cortisol is not an early event in the course of AD...
  27. ncbi request reprint Polymorphism in the BACE gene influences the risk for Alzheimer's disease
    Chartika M Kirschling
    Department of Psychiatry, University of Bonn, Germany
    Neuroreport 14:1243-6. 2003
    ..Furthermore, Abeta(42) CSF levels were influenced by BACE genotype. It appears that BACE polymorphism plays a more important role in the development of AD than previously assumed, possibly by influencing Abeta(42) levels...
  28. ncbi request reprint Association of an interleukin-1beta gene polymorphism at position -511 with Alzheimer's disease
    Christian Ehl
    Department of Psychiatry, University of Bonn, D 53105 Bonn, Germany
    Int J Mol Med 11:235-8. 2003
    ..Even though IL-1beta -511 polymorphism did not influence the risk of AD it might have a pathophysiological influence on the disease process...
  29. doi request reprint Association of the PPARgamma gene polymorphism Pro12Ala with delayed onset of multiple sclerosis
    Luisa Klotz
    Department of Neurology, University of Bonn, Germany
    Neurosci Lett 449:81-3. 2009
    ..Our population-based study demonstrates that the Pro12Ala polymorphism resulting in an amino acid exchange in the N-terminal sequence of PPARgamma may influence the onset of MS...
  30. ncbi request reprint Risk factors and early signs of Alzheimer's disease in a family study sample. Risk of AD
    Reinhard Heun
    Department of Psychiatry, University of Bonn, Venusberg, 53105 Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 256:28-36. 2006
    ....
  31. ncbi request reprint PPARD haplotype influences cholesterol metabolism but is no risk factor of Alzheimer's disease
    Julia Holzapfel
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Neurosci Lett 408:57-61. 2006
    ..8+/-7.7ng/mg; non-carriers: 58.6+/-2.3ng/mg; p=0.002) but not in non-demented controls. Our results suggest that PPARD haplotypes might influence levels of cholesterol metabolites in AD patients, but act not as risk factors of AD...
  32. ncbi request reprint Cathepsin D: screening for new polymorphisms using single-strand conformation polymorphism analysis
    Micael Majores
    Department of Psychiatry, University of Bonn, D 53105 Bonn, Germany
    Int J Mol Med 9:185-7. 2002
    ..Thus, if sequence variations within the CTSD gene influence the risk for various diseases, the pathogenic mechanism is likely to be linked to the amino acid substitution in the profragment of CTSD...
  33. ncbi request reprint The power of sample size and homogenous sampling: association between the 5-HTTLPR serotonin transporter polymorphism and major depressive disorder
    Barbara Hoefgen
    Department of Psychiatry, University of Bonn, Germany
    Biol Psychiatry 57:247-51. 2005
    ..Consistently replicated evidence for an involvement of this polymorphism in the etiology of mood disorders, particularly in major depressive disorder (MDD), remains scant...
  34. doi request reprint Cerebral and extracerebral cholesterol metabolism and CSF markers of Alzheimer's disease
    Julius Popp
    Department of Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland
    Biochem Pharmacol 86:37-42. 2013
    ..The results suggest that alterations of CNS cholesterol de novo genesis and metabolism are related to neurodegeneration and in particular to the cerebral accumulation of phosphorylated tau...
  35. doi request reprint Cholesterol metabolism is associated with soluble amyloid precursor protein production in Alzheimer's disease
    Julius Popp
    Department of Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland
    J Neurochem 123:310-6. 2012
    ..Furthermore, plasma 27-OHC concentrations were associated with the CSF sAPP levels. The results suggest that high CSF concentrations of cholesterol, 24S-OHC, and 27-OHC are associated with increased production of both sAPP forms in AD...
  36. ncbi request reprint The methionine synthase polymorphism c.2756Aright curved arrow G (D919G) is relevant for disease-free longevity
    Michael Linnebank
    Department of Neurology, University Hospital Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Int J Mol Med 16:759-61. 2005
    ..Separate analysis of female and male subjects revealed that the influence of the MTR genotype on male subjects became relevant at a younger age as opposed to female subjects suggesting a gender-dependent effect...
  37. doi request reprint Multicentre variability of MRI-based medial temporal lobe volumetry in Alzheimer's disease
    Stefan J Teipel
    Department of Psychiatry, University Rostock, Rostock, Germany
    Psychiatry Res 182:244-50. 2010
    ..Our data indicate that multicentre acquisition of MRI data using manual volumetry is reliable and feasible for cross-sectional diagnostic studies, and they replicate essential findings from smaller scale monocentre studies...
  38. pmc VKORC1-dependent pharmacokinetics of intravenous and oral phylloquinone (vitamin K1) mixed micelles formulation
    Milka Marinova
    Institute of Experimental Hematology and Transfusion Medicine, University Clinics Bonn, Sigmund Freud Strasse 25, 53127 Bonn, Germany
    Eur J Clin Pharmacol 69:467-75. 2013
    ..The subjects were allocated to one of three genotype-specific groups (n = 10 in each group) in terms of VKORC1 promoter polymorphism c.-1639 G > A to explore the relationship between genotype and pharmacokinetic parameters...
  39. doi request reprint Interaction of insulin and PPAR-α genes in Alzheimer's disease: the Epistasis Project
    Heike Kolsch
    Department of Psychiatry, University of Bonn, Bonn, Germany
    J Neural Transm 119:473-9. 2012
    ..We suggest that dysregulation of glucose metabolism contributes to the development of AD and might be due in part to genetic variations in INS and PPARA and their interaction especially in Northern Europeans...
  40. ncbi request reprint Genetic variations and humoral immune responses to myelin oligodendroglia glycoprotein in adult phenotypes of X-linked adrenoleukodystrophy
    Stephan Schmidt
    Department of Neurology, University of Bonn, Sigmund Freud Str 20, 53105, Bonn, Germany
    J Neuroimmunol 135:148-53. 2003
    ..Anti-MOG antibodies were detectable in 17/54 X-ALD patients (31.5%). Anti-MOG antibodies were associated with the 226 bp (TAAA)(n) MOG gene polymorphism but not with distinct clinical phenotypes...
  41. ncbi request reprint Homocysteine and carotid intima-media thickness in a german population: lack of clinical relevance
    Michael Linnebank
    Department of Neurology, University Hospital Bonn, Bonn, Germany
    Stroke 37:2840-2. 2006
    ..Common carotid artery intima-media thickness (CCA IMT) is a predictor of stroke. This study aimed to analyze whether homocysteine (Hcys) metabolism influences CCA IMT...
  42. doi request reprint Macrophage migration inhibitory factor in mild cognitive impairment and Alzheimer's disease
    Julius Popp
    University of Bonn, Department of Psychiatry, Bonn, Germany
    J Psychiatr Res 43:749-53. 2009
    ..407; p=0.023). These results demonstrate increased MIF production in AD and MCI suggesting that MIF may be involved in the occurring neuroinflammatory process at a clinical pre-dementia disease stage...
  43. ncbi request reprint Glucose metabolism, gray matter structure, and memory decline in subjective memory impairment
    Lukas Scheef
    Department of Radiology, University of Bonn, Bonn, Germany
    Neurology 79:1332-9. 2012
    ..To identify biological evidence for Alzheimer disease (AD) in individuals with subjective memory impairment (SMI) and unimpaired cognitive performance and to investigate the longitudinal cognitive course in these subjects...
  44. ncbi request reprint Noradrenergic modulation of emotion-induced forgetting and remembering
    Rene Hurlemann
    Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
    J Neurosci 25:6343-9. 2005
    ..We conclude that a differential processing of emotional arousal and valence influences how the brain remembers and forgets...