Rainer Kollmar

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. ncbi request reprint Different degrees of hypothermia after experimental stroke: short- and long-term outcome
    Rainer Kollmar
    Department of Neurology, University of Erlangen, Erlangen, Germany
    Stroke 38:1585-9. 2007
  2. ncbi request reprint Hypothermia reduces perihemorrhagic edema after intracerebral hemorrhage
    Rainer Kollmar
    Neurology Department, University of Erlangen, Erlangen, Germany
    Stroke 41:1684-9. 2010
  3. ncbi request reprint Combination therapy of moderate hypothermia and thrombolysis in experimental thromboembolic stroke--an MRI study
    Rainer Kollmar
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Exp Neurol 190:204-12. 2004
  4. ncbi request reprint Evolution of early perihemorrhagic changes--ischemia vs. edema: an MRI study in rats
    Berk Orakcioglu
    Department of Neurology, University of Heidelberg, Germany Department of Neurosurgery, University of Heidelberg, Germany
    Exp Neurol 193:369-76. 2005
  5. doi request reprint Cooling in intracerebral hemorrhage (CINCH) trial: protocol of a randomized German-Austrian clinical trial
    Rainer Kollmar
    Department of Neurology, University Hospital Erlangen Friedrich Alexander Universität Erlangen Nürnberg, Erlangen, Germany
    Int J Stroke 7:168-72. 2012
  6. doi request reprint Head and neck cooling decreases tympanic and skin temperature, but significantly increases blood pressure
    Julia Koehn
    Department of Neurology, University of Erlangen Nuremberg, Erlangen, Germany
    Stroke 43:2142-8. 2012
  7. ncbi request reprint Alpha-stat versus pH-stat guided ventilation in patients with large ischemic stroke treated by hypothermia
    Rainer Kollmar
    Department of Neurology, University Hospital Erlangen, University of Erlangen, Schwabachanlage 6, Erlangen 91054, Germany
    Neurocrit Care 10:173-80. 2009
  8. doi request reprint Local head and neck cooling leads to hypothermia in healthy volunteers
    Bernd Kallmünzer
    Department of Neurology, University Hospital Erlangen, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    Cerebrovasc Dis 32:207-10. 2011
  9. ncbi request reprint Energy demand in patients with stroke who are sedated and receiving mechanical ventilation
    Juergen Bardutzky
    Department of Neurology, University of Heidelberg, Germany
    J Neurosurg 100:266-71. 2004
  10. doi request reprint A structured reading algorithm improves telemetric detection of atrial fibrillation after acute ischemic stroke
    Bernd Kallmünzer
    Department of Neurology, University Medical Center Erlangen, Schwabachanlage 6, 91054 Erlangen, Germany
    Stroke 43:994-9. 2012

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Different degrees of hypothermia after experimental stroke: short- and long-term outcome
    Rainer Kollmar
    Department of Neurology, University of Erlangen, Erlangen, Germany
    Stroke 38:1585-9. 2007
    ..Still, several issues, including optimal target temperature, remain unclear. The optimal depth of hypothermia in a rat model of focal cerebral ischemia was investigated...
  2. ncbi request reprint Hypothermia reduces perihemorrhagic edema after intracerebral hemorrhage
    Rainer Kollmar
    Neurology Department, University of Erlangen, Erlangen, Germany
    Stroke 41:1684-9. 2010
    ..Because the efficacy of surgical and anti-edematous treatment strategies is limited, we investigated the effects of mild induced hypothermia in patients with large sICH...
  3. ncbi request reprint Combination therapy of moderate hypothermia and thrombolysis in experimental thromboembolic stroke--an MRI study
    Rainer Kollmar
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Exp Neurol 190:204-12. 2004
    ..However, there were no significant differences between the use of rt-PA alone or in combination with hypothermia. Further studies are needed to confirm these effects, also several days after stroke onset...
  4. ncbi request reprint Evolution of early perihemorrhagic changes--ischemia vs. edema: an MRI study in rats
    Berk Orakcioglu
    Department of Neurology, University of Heidelberg, Germany Department of Neurosurgery, University of Heidelberg, Germany
    Exp Neurol 193:369-76. 2005
    ..The search for surrogate parameters that allow treatment stratification for spontaneous ICH continues. We aimed to examine perihemorrhagic ischemic changes with an animal experimental MRI study...
  5. doi request reprint Cooling in intracerebral hemorrhage (CINCH) trial: protocol of a randomized German-Austrian clinical trial
    Rainer Kollmar
    Department of Neurology, University Hospital Erlangen Friedrich Alexander Universität Erlangen Nürnberg, Erlangen, Germany
    Int J Stroke 7:168-72. 2012
    ..Promising experimental and pilot clinical data support the use of therapeutic hypothermia after intracerebral hemorrhage...
  6. doi request reprint Head and neck cooling decreases tympanic and skin temperature, but significantly increases blood pressure
    Julia Koehn
    Department of Neurology, University of Erlangen Nuremberg, Erlangen, Germany
    Stroke 43:2142-8. 2012
    ..Safety issues of head and neck cooling are undetermined and may include cardiovascular autonomic side effects that were identified in this study...
  7. ncbi request reprint Alpha-stat versus pH-stat guided ventilation in patients with large ischemic stroke treated by hypothermia
    Rainer Kollmar
    Department of Neurology, University Hospital Erlangen, University of Erlangen, Schwabachanlage 6, Erlangen 91054, Germany
    Neurocrit Care 10:173-80. 2009
    ..Therefore, effects of ventilation on CBF and ICP were measured in patients undergoing MH because of large ischemic stroke to address optimal ventilation management...
  8. doi request reprint Local head and neck cooling leads to hypothermia in healthy volunteers
    Bernd Kallmünzer
    Department of Neurology, University Hospital Erlangen, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    Cerebrovasc Dis 32:207-10. 2011
    ..Prehospital cooling of acute stroke patients would be ideal when associated with minor or no side effects. Therefore, we evaluated a cooling cap for the surface of head and cervical regions in awake volunteers...
  9. ncbi request reprint Energy demand in patients with stroke who are sedated and receiving mechanical ventilation
    Juergen Bardutzky
    Department of Neurology, University of Heidelberg, Germany
    J Neurosurg 100:266-71. 2004
    ....
  10. doi request reprint A structured reading algorithm improves telemetric detection of atrial fibrillation after acute ischemic stroke
    Bernd Kallmünzer
    Department of Neurology, University Medical Center Erlangen, Schwabachanlage 6, 91054 Erlangen, Germany
    Stroke 43:994-9. 2012
    ..In this study, the sensitivity of AF detection was assessed for serial electrocardiographic recordings and continuous stroke unit telemetric monitoring with or without a structured algorithm to analyze telemetric data (SEA-AF)...
  11. doi request reprint Ice-cold saline for the induction of mild hypothermia in patients with acute ischemic stroke: a pilot study
    Rainer Kollmar
    Department of Neurology, University of Erlangen Nuernberg, Erlangen, Germany
    Stroke 40:1907-9. 2009
    ..Preliminary studies in cardiac arrest patients indicate that rapid infusion of ice cold saline (ICS) is safe and effective for induction of hypothermia. We investigated its use in patients with acute ischemic stroke (AIS)...
  12. ncbi request reprint Impaired spatial learning in a novel rat model of mild cerebral concussion injury
    Nils Henninger
    Department of Neurology, University of Heidelberg, 69120 Heidelberg, Germany
    Exp Neurol 195:447-57. 2005
    ..We present a unique, noninvasive rat model of mild closed head trauma with characteristics of human concussion injury, including brief loss of consciousness, cognitive impairment, and minor brain injury...
  13. doi request reprint Weight approximation in stroke before thrombolysis: the WAIST-Study: a prospective observational "dose-finding" study
    Lorenz Breuer
    Department of Neurology, University of Erlangen Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany
    Stroke 41:2867-71. 2010
    ..The aim of our study was to evaluate availability of BW information, accuracy of estimations, and final dosing of Alteplase (tissue plasminogen activator [tPA]) in a routine clinical setting...
  14. doi request reprint Inhibited glutamate release by granulocyte-colony stimulating factor after experimental stroke
    Jun Liang Han
    Department of Neurology, University of Heidelberg, 69120 Heidelberg, Germany
    Neurosci Lett 432:167-9. 2008
    ..The result of present study show that G-CSF possess an ability to inhibit excitotoxicity after ischemic stroke...
  15. ncbi request reprint Energy expenditure in ischemic stroke patients treated with moderate hypothermia
    Juergen Bardutzky
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Intensive Care Med 30:151-4. 2004
    ..To determine total energy expenditure (TEE) in patients with acute ischemic stroke in the territory of the middle cerebral artery (MCA), treated with moderate hypothermia (33 degrees C)...
  16. doi request reprint Standardized antipyretic treatment in stroke: a pilot study
    Bernd Kallmünzer
    Department of Neurology, University Medical Center Erlangen Nuremberg, Germany
    Cerebrovasc Dis 31:382-9. 2011
    ..This study investigated an institutional standard operating procedure (SOP) for fever treatment in stroke patients including a sequence of pharmacologic and physical interventions...
  17. doi request reprint Early administration of low molecular weight heparin after spontaneous intracerebral hemorrhage. A safety analysis
    Ines C Kiphuth
    Department of Neurology, University of Erlangen, Schwabachanlage 6, Erlangen, Germany
    Cerebrovasc Dis 27:146-50. 2009
    ..The objective of this study was to assess the safety of early subcutaneous LMWH in patients with sICH with respect to hemorrhage enlargement...
  18. ncbi request reprint Early effects of acid-base management during hypothermia on cerebral infarct volume, edema, and cerebral blood flow in acute focal cerebral ischemia in rats
    Rainer Kollmar
    Department of Neurology, University of Heidelberg, Germany
    Anesthesiology 97:868-74. 2002
    ..This study investigates the effect of pH- and alpha-stat acid-base management on cerebral blood flow (CBF), infarct volume, and cerebral edema in a model of transient focal cerebral ischemia in rats...
  19. doi request reprint Mild prolonged hypothermia for large intracerebral hemorrhage
    Dimitre Staykov
    Department of Neurology, University of Erlangen Nuremberg, Schwabachanlage 6, 91054, Erlangen, Germany
    Neurocrit Care 18:178-83. 2013
    ..It can worsen the clinical situation by its additional mass effect. Therapeutic hypothermia (TH) might be an effective method to control PHE, but has not been sufficiently studied in ICH patients...
  20. ncbi request reprint Neuroprotection by hyperbaric oxygenation after experimental focal cerebral ischemia monitored by MRI
    Wolf Ruediger Schabitz
    Department of Neurology, University of Heidelberg, Germany
    Stroke 35:1175-9. 2004
    ..Here, we evaluated effects of HBO on permanent focal cerebral ischemia and applied magnetic resonance imaging (MRI) monitoring to study lesion evolution...
  21. doi request reprint Hypothermia in focal ischemia: implications of experiments and experience
    Rainer Kollmar
    Department of Neurology, University of Erlangen Nurnberg, Erlangen, Germany
    J Neurotrauma 26:377-86. 2009
    ..Methods of delivery and maintenance of hypothermia are discussed, as well as a variety of open questions in the relevant animal and clinical research...
  22. ncbi request reprint Hypothermia reduces perihemorrhagic edema after intracerebral hemorrhage: but does it influence functional outcome and mortality?
    Dimitre Staykov
    1 Department of Neurology, University of Erlangen Nuremberg, Erlangen, Germany
    Ther Hypothermia Temp Manag 1:105-6. 2011
    ..TH may be a promising treatment option for patients with large ICH, since pilot data indicate a high survival rate and a high chance for an acceptable functional long-term outcome. ..
  23. doi request reprint AXIS: a trial of intravenous granulocyte colony-stimulating factor in acute ischemic stroke
    Wolf R Schabitz
    Department of Neurology, University of Munster, Munster, Germany
    Stroke 41:2545-51. 2010
    ..The present phase IIa study assessed safety and tolerability over a broad dose range of G-CSF doses in acute ischemic stroke patients and explored outcome data...
  24. ncbi request reprint Stroke MRI in intracerebral hemorrhage: is there a perihemorrhagic penumbra?
    Peter D Schellinger
    Department of Neurology, University of Heidelberg, Heidelberg, Germany
    Stroke 34:1674-9. 2003
    ..We sought to assess the presence and prognostic effect of perihemorrhagic ischemic changes and hypoperfusion in a prospective stroke MRI study...
  25. doi request reprint Temperature management in stroke - an unsolved, but important topic
    Bernd Kallmünzer
    Department of Neurology, University of Erlangen Nurnberg, Germany
    Cerebrovasc Dis 31:532-43. 2011
    ..Given the promising data and the lack of successful acute neuroprotective therapies available thus far, suggestions are given for future investigation on both topics...
  26. doi request reprint International normalised ratio normalisation in patients with coumarin-related intracranial haemorrhages--the INCH trial: a randomised controlled multicentre trial to compare safety and preliminary efficacy of fresh frozen plasma and prothrombin complex--
    Thorsten Steiner
    Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany
    Int J Stroke 6:271-7. 2011
    ..of the international normalized ratio? How feasible is it to apply either of these treatments in an acute situation? What is the safety profile of each of these substances? Is there a difference in haematoma growth and clinical outcome?..
  27. doi request reprint Suppression of dendritic cell functions contributes to the anti-inflammatory action of granulocyte-colony stimulating factor in experimental stroke
    Barbara Dietel
    Department of Neurology, University Hospital Erlangen, Erlangen, Germany
    Exp Neurol 237:379-87. 2012
    ..Suppression of both enhanced DC migration and maturation might contribute to the neuroprotective action of G-CSF in experimental stroke...
  28. pmc Mild hypothermia of 34°C reduces side effects of rt-PA treatment after thromboembolic stroke in rats
    Bernd Kallmünzer
    Department of Neurology, University of Erlangen, Germany
    Exp Transl Stroke Med 4:3. 2012
    ..abstract:..
  29. pmc G-CSF, rt-PA and combination therapy after experimental thromboembolic stroke
    Rainer Kollmar
    Department of Neurology, University of Erlangen, Erlangen, Germany
    Exp Transl Stroke Med 2:9. 2010
    ..Early combination with rt-PA showed no additional benefit compared to rt-PA or G-CSF alone, but did not lead to side effects. Pretreatment by G-CSF was able to reduce deleterious effects of late rt-PA treatment...
  30. ncbi request reprint Influence of inspiration:expiration ratio on intracranial and cerebral perfusion pressure in acute stroke patients
    Dimitrios Georgiadis
    Department of Neurology, University of Heidelberg, Germany
    Intensive Care Med 28:1089-93. 2002
    ..We undertook this study to evaluate the influence of the inspiration:expiration (I:E) ratio on intracranial pressure and cerebral perfusion in patients with acute stroke...
  31. ncbi request reprint A new model of thromboembolic stroke in the posterior circulation of the rat
    Nils Henninger
    Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01609, USA
    J Neurosci Methods 156:1-9. 2006
    ..Hence, successful thromboembolism was achieved in 12 of 15 animals (80%). With this novel model, the pathophysiology and potential treatments of posterior circulation stroke can be investigated...
  32. pmc The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis
    Armin Schneider
    Axaron Bioscience AG, Heidelberg, Germany
    J Clin Invest 115:2083-98. 2005
    ..We therefore propose G-CSF as a potential new drug for stroke and neurodegenerative diseases...
  33. ncbi request reprint In search of the silver bullet: fast and safe cooling for brain injury?
    Rainer Kollmar
    Crit Care Med 33:1452-3. 2005
  34. ncbi request reprint Granulocyte colony stimulating factor: just another neuroprotectant?
    Rainer Kollmar
    Crit Care Med 32:2357-8. 2004
  35. ncbi request reprint Rise of the machines: controlling the body temperature of critically ill patients by endovascular catheters
    Stefan Schwab
    Neurocrit Care 1:127-30. 2004
  36. ncbi request reprint Exogenous brain-derived neurotrophic factor prevents postischemic downregulation of [3H]muscimol binding to GABA(A) receptors in the cortical penumbra
    Clemens Sommer
    Department of Neuropathology, Ruprecht Karls University of Heidelberg, Heidelberg, Germany
    Brain Res Mol Brain Res 111:24-30. 2003
    ....