Elzbieta Kojro

Summary

Affiliation: University of Mainz
Country: Germany

Publications

  1. doi request reprint Regulated proteolysis of RAGE and AbetaPP as possible link between type 2 diabetes mellitus and Alzheimer's disease
    Elzbieta Kojro
    Institute of Biochemistry, Johannes Gutenberg University Mainz, Mainz, Germany
    J Alzheimers Dis 16:865-78. 2009
  2. pmc Neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) slows down Alzheimer's disease-like pathology in amyloid precursor protein-transgenic mice
    Dorothea Rat
    Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany
    FASEB J 25:3208-18. 2011
  3. doi request reprint Statins and the squalene synthase inhibitor zaragozic acid stimulate the non-amyloidogenic pathway of amyloid-beta protein precursor processing by suppression of cholesterol synthesis
    Elzbieta Kojro
    Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany
    J Alzheimers Dis 20:1215-31. 2010
  4. ncbi request reprint The neuropeptide PACAP promotes the alpha-secretase pathway for processing the Alzheimer amyloid precursor protein
    Elzbieta Kojro
    Institute of Biochemistry, Johannes Gutenberg University, Becherweg, Mainz, Germany
    FASEB J 20:512-4. 2006
  5. ncbi request reprint Tumor necrosis factor-alpha converting enzyme is processed by proprotein-convertases to its mature form which is degraded upon phorbol ester stimulation
    Kristina Endres
    Institute of Biochemistry, Johannes Gutenberg University, Mainz, Germany
    Eur J Biochem 270:2386-93. 2003
  6. pmc A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model
    Rolf Postina
    Institute of Biochemistry, University of Mainz, Mainz, Germany
    J Clin Invest 113:1456-64. 2004
  7. pmc Induction of RAGE shedding by activation of G protein-coupled receptors
    Verena V Metz
    Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany
    PLoS ONE 7:e41823. 2012
  8. ncbi request reprint Receptor for advanced glycation end products is subjected to protein ectodomain shedding by metalloproteinases
    Ling Zhang
    Institute of Biochemistry, Johannes Gutenberg University of Mainz, Becherweg 30, Mainz D 55099, Germany
    J Biol Chem 283:35507-16. 2008
  9. ncbi request reprint Influence of ADAM10 on prion protein processing and scrapie infectiosity in vivo
    Kristina Endres
    Institute of Biochemistry, Johannes Gutenberg University, Johann Joachim Becherweg 30, D 55128 Mainz, Germany
    Neurobiol Dis 36:233-41. 2009
  10. ncbi request reprint The non-amyloidogenic pathway: structure and function of alpha-secretases
    Elzbieta Kojro
    Institute of Biochemistry, Johannes Gutenberg University, Mainz, Germany
    Subcell Biochem 38:105-27. 2005

Collaborators

Detail Information

Publications13

  1. doi request reprint Regulated proteolysis of RAGE and AbetaPP as possible link between type 2 diabetes mellitus and Alzheimer's disease
    Elzbieta Kojro
    Institute of Biochemistry, Johannes Gutenberg University Mainz, Mainz, Germany
    J Alzheimers Dis 16:865-78. 2009
    ..Current data suggest that the sequential proteolysis of RAGE is homologous to AbetaPP processing...
  2. pmc Neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) slows down Alzheimer's disease-like pathology in amyloid precursor protein-transgenic mice
    Dorothea Rat
    Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany
    FASEB J 25:3208-18. 2011
    ..Thus, nasal application of PACAP was effective, and our results indicate that PACAP could be of therapeutic value in treating AD...
  3. doi request reprint Statins and the squalene synthase inhibitor zaragozic acid stimulate the non-amyloidogenic pathway of amyloid-beta protein precursor processing by suppression of cholesterol synthesis
    Elzbieta Kojro
    Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany
    J Alzheimers Dis 20:1215-31. 2010
    ..Our results indicate that inhibition of cholesterol biosynthesis by a low lovastatin concentration is sufficient for alpha-secretase activation...
  4. ncbi request reprint The neuropeptide PACAP promotes the alpha-secretase pathway for processing the Alzheimer amyloid precursor protein
    Elzbieta Kojro
    Institute of Biochemistry, Johannes Gutenberg University, Becherweg, Mainz, Germany
    FASEB J 20:512-4. 2006
    ..Our findings provide evidence for a role of the neuropeptide PACAP in stimulation of the nonamyloidogenic pathway, which might be related to its neuroprotective properties...
  5. ncbi request reprint Tumor necrosis factor-alpha converting enzyme is processed by proprotein-convertases to its mature form which is degraded upon phorbol ester stimulation
    Kristina Endres
    Institute of Biochemistry, Johannes Gutenberg University, Mainz, Germany
    Eur J Biochem 270:2386-93. 2003
    ....
  6. pmc A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model
    Rolf Postina
    Institute of Biochemistry, University of Mainz, Mainz, Germany
    J Clin Invest 113:1456-64. 2004
    ....
  7. pmc Induction of RAGE shedding by activation of G protein-coupled receptors
    Verena V Metz
    Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany
    PLoS ONE 7:e41823. 2012
    ..Our findings suggest that pharmacological stimulation of RAGE shedding might open alternative treatment strategies for Alzheimers disease and diabetes-induced inflammation...
  8. ncbi request reprint Receptor for advanced glycation end products is subjected to protein ectodomain shedding by metalloproteinases
    Ling Zhang
    Institute of Biochemistry, Johannes Gutenberg University of Mainz, Becherweg 30, Mainz D 55099, Germany
    J Biol Chem 283:35507-16. 2008
    ..Identification of these novel mechanisms involved in regulating the availability of cell surface-located RAGE and its soluble ectodomain may influence further research in RAGE-mediated processes in cell biology and pathophysiology...
  9. ncbi request reprint Influence of ADAM10 on prion protein processing and scrapie infectiosity in vivo
    Kristina Endres
    Institute of Biochemistry, Johannes Gutenberg University, Johann Joachim Becherweg 30, D 55128 Mainz, Germany
    Neurobiol Dis 36:233-41. 2009
    ..This indicates that overexpression of ADAM10 rather influences the amount of the cellular prion protein than its processing in vivo...
  10. ncbi request reprint The non-amyloidogenic pathway: structure and function of alpha-secretases
    Elzbieta Kojro
    Institute of Biochemistry, Johannes Gutenberg University, Mainz, Germany
    Subcell Biochem 38:105-27. 2005
    ..We also discuss the pharmacological up-regulation of alpha-secretases as a possible therapeutic treatment for AD...
  11. pmc Statins stimulate the production of a soluble form of the receptor for advanced glycation end products
    Patricia Quade-Lyssy
    Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, D 55128 Mainz, Germany
    J Lipid Res 54:3052-61. 2013
    ..Our results show that statins, due to their cholesterol-lowering effects, increase the soluble RAGE level by inducing RAGE shedding, and by doing this, might prevent the development of RAGE-mediated pathogenesis. ..
  12. doi request reprint CSF APPs alpha and phosphorylated tau protein levels in mild cognitive impairment and dementia of Alzheimer's type
    Andreas Fellgiebel
    Department of Psychiatry, Johannes Gutenberg University Mainz, Germany
    J Geriatr Psychiatry Neurol 22:3-9. 2009
    ..Both, an increase in p tau levels and a decrease in cerebrospinal fluid APPs alpha, seem to refer to relevant but functionally different processes in the development of mild cognitive impairment and dementia of Alzheimer's type...
  13. doi request reprint Photo-DHEA--a functional photoreactive dehydroepiandrosterone (DHEA) analog
    Gustav Waschatko
    Institute of Pharmacy and Biochemistry, University of Mainz, Becherweg 30, 55099 Mainz, Germany
    Steroids 76:502-7. 2011
    ..In cell-based assays, Photo-DHEA showed the same properties as DHEA. We conclude that Photo-DHEA is suitable for radioiodination to yield a tool for the identification of the elusive DHEA receptor...