Affiliation: University of Mainz
- Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10E Kojro
Institute of Biochemistry, Johannes Gutenberg University, Becherweg 30, D 55128 Mainz, Germany
Proc Natl Acad Sci U S A 98:5815-20. 2001....
- Alpha-secretase activity of the disintegrin metalloprotease ADAM 10. Influences of domain structureF Fahrenholz
Institut fur Biochemie, Johannes Gutenberg Universitat, Becherweg 30, D 55128 Mainz, Germany
Ann N Y Acad Sci 920:215-22. 2000..Our findings demonstrate that the deletion of the disintegrin domain results in a mutant ADAM 10 with remaining alpha-secretase activity, whereas the deletion of the prodomain destroys the proteolytic activity of ADAM 10...
- Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloproteaseS Lammich
Institut fur Biochemie, Johannes Gutenberg Universitat, Mainz, Becherweg 30, D 55128 Mainz, Germany
Proc Natl Acad Sci U S A 96:3922-7. 1999..Increases of its expression and activity might be beneficial for the treatment of Alzheimer's disease...
- Direct identification of the agonist binding site in the human brain cholecystokininB receptorJ Anders
Institut fur Biochemie, Johannes Gutenberg Universitat Mainz, Becherweg 30, D 55099 Mainz, Germany
Biochemistry 38:6043-55. 1999..The hormone was found to be placed in a binding pocket built from both extracellular and transmembrane domains of CCKBR with its N-terminus mainly interacting with residues Arg57 and Tyr61...