E Kojro

Summary

Affiliation: University of Mainz
Country: Germany

Publications

  1. pmc Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10
    E Kojro
    Institute of Biochemistry, Johannes Gutenberg University, Becherweg 30, D 55128 Mainz, Germany
    Proc Natl Acad Sci U S A 98:5815-20. 2001
  2. ncbi request reprint Alpha-secretase activity of the disintegrin metalloprotease ADAM 10. Influences of domain structure
    F Fahrenholz
    Institut fur Biochemie, Johannes Gutenberg Universitat, Becherweg 30, D 55128 Mainz, Germany
    Ann N Y Acad Sci 920:215-22. 2000
  3. pmc Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease
    S Lammich
    Institut fur Biochemie, Johannes Gutenberg Universitat, Mainz, Becherweg 30, D 55128 Mainz, Germany
    Proc Natl Acad Sci U S A 96:3922-7. 1999
  4. ncbi request reprint Direct identification of the agonist binding site in the human brain cholecystokininB receptor
    J Anders
    Institut fur Biochemie, Johannes Gutenberg Universitat Mainz, Becherweg 30, D 55099 Mainz, Germany
    Biochemistry 38:6043-55. 1999

Collaborators

  • G Gimpl
  • F Fahrenholz
  • S Lammich
  • S Gilbert
  • R Postina
  • J Anders
  • R Kühne
  • M Blüggel
  • A M ter Laak
  • R Pfeiffer
  • M Jasionowski
  • C Haass
  • H E Meyer

Detail Information

Publications4

  1. pmc Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10
    E Kojro
    Institute of Biochemistry, Johannes Gutenberg University, Becherweg 30, D 55128 Mainz, Germany
    Proc Natl Acad Sci U S A 98:5815-20. 2001
    ....
  2. ncbi request reprint Alpha-secretase activity of the disintegrin metalloprotease ADAM 10. Influences of domain structure
    F Fahrenholz
    Institut fur Biochemie, Johannes Gutenberg Universitat, Becherweg 30, D 55128 Mainz, Germany
    Ann N Y Acad Sci 920:215-22. 2000
    ..Our findings demonstrate that the deletion of the disintegrin domain results in a mutant ADAM 10 with remaining alpha-secretase activity, whereas the deletion of the prodomain destroys the proteolytic activity of ADAM 10...
  3. pmc Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease
    S Lammich
    Institut fur Biochemie, Johannes Gutenberg Universitat, Mainz, Becherweg 30, D 55128 Mainz, Germany
    Proc Natl Acad Sci U S A 96:3922-7. 1999
    ..Increases of its expression and activity might be beneficial for the treatment of Alzheimer's disease...
  4. ncbi request reprint Direct identification of the agonist binding site in the human brain cholecystokininB receptor
    J Anders
    Institut fur Biochemie, Johannes Gutenberg Universitat Mainz, Becherweg 30, D 55099 Mainz, Germany
    Biochemistry 38:6043-55. 1999
    ..The hormone was found to be placed in a binding pocket built from both extracellular and transmembrane domains of CCKBR with its N-terminus mainly interacting with residues Arg57 and Tyr61...