Christoph Kohler

Summary

Affiliation: University of Cologne
Country: Germany

Publications

  1. pmc The actin-binding protein caldesmon is in spleen and lymph nodes predominately expressed by smooth-muscle cells, reticular cells, and follicular dendritic cells
    Christoph N Köhler
    Institute II of Anatomy, Medical Faculty, University of Cologne, 50931 Cologne, Germany
    J Histochem Cytochem 58:183-93. 2010
  2. doi Active glycogen synthase kinase-3 and tau pathology-related tyrosine phosphorylation in pR5 human tau transgenic mice
    Christoph Kohler
    Institute II for Anatomy, Medical Faculty, University of Cologne, Cologne, Germany
    Neurobiol Aging 34:1369-79. 2013
  3. doi Histochemical localization of caldesmon isoforms in colon adenocarcinoma and lymph node metastases
    Christoph Kohler
    Institute II of Anatomy, Medical Faculty, University of Cologne, Kerpener Str 62, 50924 Cologne, Germany
    Virchows Arch 459:81-9. 2011
  4. pmc Histochemical localization of caldesmon in the CNS and ganglia of the mouse
    Christoph N Köhler
    Institute II of Anatomy, Medical Faculty, University of Cologne, Cologne, Germany
    J Histochem Cytochem 59:504-17. 2011
  5. ncbi Analysis of the cholinergic pathology in the P301L tau transgenic pR5 model of tauopathy
    C Kohler
    Dept of Anatomy Neuroanatomy, University Hospital Cologne, Cologne, Germany
    Brain Res 1347:111-24. 2010
  6. ncbi Alzheimer's disease-like neuropathology of gene-targeted APP-SLxPS1mut mice expressing the amyloid precursor protein at endogenous levels
    Christoph Kohler
    Institute II of Anatomy, Department of Neuroanatomy, University of Cologne, Josef Stelzmann Strasse 9, D 50931 Cologne, Germany
    Neurobiol Dis 20:528-40. 2005
  7. ncbi Allograft inflammatory factor-1/Ionized calcium-binding adapter molecule 1 is specifically expressed by most subpopulations of macrophages and spermatids in testis
    Christoph Kohler
    Institute II of Anatomy, University of Cologne, Joseph Stelzmann Strasse 9, 50931, Cologne, Germany
    Cell Tissue Res 330:291-302. 2007
  8. doi IRS-2 branch of IGF-1 receptor signaling is essential for appropriate timing of myelination
    Susanna Freude
    Department of Internal Medicine II, University of Cologne, Cologne, Germany
    J Neurochem 107:907-17. 2008
  9. doi Pattern of tau hyperphosphorylation and neurotransmitter markers in the brainstem of senescent tau filament forming transgenic mice
    Kerstin Morcinek
    Department of Anatomy II Neuroanatomy, University of Cologne, Kerpener Straβe 62, 50924 Cologne, Germany
    Brain Res 1497:73-84. 2013
  10. doi Neuronal IGF-1 resistance reduces Abeta accumulation and protects against premature death in a model of Alzheimer's disease
    Susanna Freude
    Department of Internal Medicine II, University of Cologne, Kerpener Str 62, 50937 Cologne, Germany
    FASEB J 23:3315-24. 2009

Collaborators

Detail Information

Publications11

  1. pmc The actin-binding protein caldesmon is in spleen and lymph nodes predominately expressed by smooth-muscle cells, reticular cells, and follicular dendritic cells
    Christoph N Köhler
    Institute II of Anatomy, Medical Faculty, University of Cologne, 50931 Cologne, Germany
    J Histochem Cytochem 58:183-93. 2010
    ..In spleen of SCID mice, caldesmon was expressed by reticular cells in the absence of lymphocytes...
  2. doi Active glycogen synthase kinase-3 and tau pathology-related tyrosine phosphorylation in pR5 human tau transgenic mice
    Christoph Kohler
    Institute II for Anatomy, Medical Faculty, University of Cologne, Cologne, Germany
    Neurobiol Aging 34:1369-79. 2013
    ..They also reveal for the mouse models studied, that tau- rather than an amyloid-β peptide-induced pathology is associated with increased neuronal tyrosine phosphorylation...
  3. doi Histochemical localization of caldesmon isoforms in colon adenocarcinoma and lymph node metastases
    Christoph Kohler
    Institute II of Anatomy, Medical Faculty, University of Cologne, Kerpener Str 62, 50924 Cologne, Germany
    Virchows Arch 459:81-9. 2011
    ..Our results show a differential behavior of h- and l-caldesmon isoforms in epithelium and stroma of colon adenocarcinoma and lymph node metastases...
  4. pmc Histochemical localization of caldesmon in the CNS and ganglia of the mouse
    Christoph N Köhler
    Institute II of Anatomy, Medical Faculty, University of Cologne, Cologne, Germany
    J Histochem Cytochem 59:504-17. 2011
    ....
  5. ncbi Analysis of the cholinergic pathology in the P301L tau transgenic pR5 model of tauopathy
    C Kohler
    Dept of Anatomy Neuroanatomy, University Hospital Cologne, Cologne, Germany
    Brain Res 1347:111-24. 2010
    ..Our data show that although pR5 mice develop neurofibrillary lesions, they do not model the degeneration of basal forebrain cholinergic neurons observed in Alzheimer's disease...
  6. ncbi Alzheimer's disease-like neuropathology of gene-targeted APP-SLxPS1mut mice expressing the amyloid precursor protein at endogenous levels
    Christoph Kohler
    Institute II of Anatomy, Department of Neuroanatomy, University of Cologne, Josef Stelzmann Strasse 9, D 50931 Cologne, Germany
    Neurobiol Dis 20:528-40. 2005
    ..However, plaque development started much later and developed slowly until the age of 18 months but then increased more rapidly...
  7. ncbi Allograft inflammatory factor-1/Ionized calcium-binding adapter molecule 1 is specifically expressed by most subpopulations of macrophages and spermatids in testis
    Christoph Kohler
    Institute II of Anatomy, University of Cologne, Joseph Stelzmann Strasse 9, 50931, Cologne, Germany
    Cell Tissue Res 330:291-302. 2007
    ..AIF-1/Iba1 can be regarded a "pan-macrophage marker" because, except for alveolar macrophages, all subpopulations of macrophages examined express AIF-1/Iba1...
  8. doi IRS-2 branch of IGF-1 receptor signaling is essential for appropriate timing of myelination
    Susanna Freude
    Department of Internal Medicine II, University of Cologne, Cologne, Germany
    J Neurochem 107:907-17. 2008
    ..Furthermore, in neuronal/brain-specific insulin receptor knockout mice myelination was unchanged. Thus, our experiments reveal that IGF-1R/IRS-2 mediated signals are critical for appropriate timing of myelination in vivo...
  9. doi Pattern of tau hyperphosphorylation and neurotransmitter markers in the brainstem of senescent tau filament forming transgenic mice
    Kerstin Morcinek
    Department of Anatomy II Neuroanatomy, University of Cologne, Kerpener Straβe 62, 50924 Cologne, Germany
    Brain Res 1497:73-84. 2013
    ....
  10. doi Neuronal IGF-1 resistance reduces Abeta accumulation and protects against premature death in a model of Alzheimer's disease
    Susanna Freude
    Department of Internal Medicine II, University of Cologne, Kerpener Str 62, 50937 Cologne, Germany
    FASEB J 23:3315-24. 2009
    ..However, neuronal IR deletion had no influence on lethality of Tg2576 mice. Thus, impaired IGF-1/IRS-2 signaling prevents premature death and delays amyloid accumulation in a model of AD...
  11. doi Deficiency of the splicing factor Sfrs10 results in early embryonic lethality in mice and has no impact on full-length SMN/Smn splicing
    Ylva Mende
    Institute of Human Genetics, Center for Molecular Medicine Cologne, University of Cologne, Cologne 50931, Germany
    Hum Mol Genet 19:2154-67. 2010
    ..Surprisingly, deletion of Sfrs10 by recombinant Cre showed no impact on SMN2 splicing but increased SMN levels. Our findings highlight the complexity by which alternatively spliced exons are regulated in vivo...