Wolfgang Koenig

Summary

Affiliation: University of Ulm
Country: Germany

Publications

  1. pmc Acute-Phase Serum Amyloid A Protein and Its Implication in the Development of Type 2 Diabetes in the KORA S4/F4 Study
    Carola Marzi
    Corresponding author Wolfgang Koenig
    Diabetes Care 36:1321-6. 2013
  2. doi request reprint Cardiac troponin T measured by a high-sensitivity assay predicts recurrent cardiovascular events in stable coronary heart disease patients with 8-year follow-up
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Centre, Ulm, Germany
    Clin Chem 58:1215-24. 2012
  3. doi request reprint Variability of fibrinogen measurements in post-myocardial infarction patients. Results from the AIRGENE study center Augsburg
    Jens Baumert
    Institute of Epidemiology II, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Thromb Haemost 107:895-902. 2012
  4. pmc Short-term effects of air pollution: a panel study of blood markers in patients with chronic pulmonary disease
    Katharina Hildebrandt
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Epidemiology, Munich, Germany
    Part Fibre Toxicol 6:25. 2009
  5. pmc Overweight, physical activity, tobacco and alcohol consumption in a cross-sectional random sample of German adults
    Mark M Haenle
    Department of Internal Medicine I, University Hospital Ulm, Robert Koch Str, 8, 89081 Ulm, Germany
    BMC Public Health 6:233. 2006
  6. pmc Association between variations in the TLR4 gene and incident type 2 diabetes is modified by the ratio of total cholesterol to HDL-cholesterol
    Melanie Kolz
    Institute of Epidemiology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany
    BMC Med Genet 9:9. 2008
  7. ncbi request reprint Biomarkers of atherosclerotic plaque instability and rupture
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Robert Koch Str 8, D 89081 Ulm, Germany
    Arterioscler Thromb Vasc Biol 27:15-26. 2007
  8. doi request reprint Update on integrated biomarkers for assessment of long-term risk of cardiovascular complications in initially healthy subjects and patients with manifest atherosclerosis
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Albert Einstein Allee 23, Ulm, Germany
    Ann Med 41:332-43. 2009
  9. doi request reprint Integrating biomarkers: the new frontier?
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Scand J Clin Lab Invest Suppl 242:117-23. 2010
  10. doi request reprint Lipoprotein-associated and secretory phospholipase A2 in cardiovascular disease: the epidemiological evidence
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Albert Einstein Allee, 23, 89081, Ulm, Germany
    Cardiovasc Drugs Ther 23:85-92. 2009

Detail Information

Publications114 found, 100 shown here

  1. pmc Acute-Phase Serum Amyloid A Protein and Its Implication in the Development of Type 2 Diabetes in the KORA S4/F4 Study
    Carola Marzi
    Corresponding author Wolfgang Koenig
    Diabetes Care 36:1321-6. 2013
    ..008, n = 803). CONCLUSIONS Our findings indicate similarly strong prospective associations with type 2 diabetes for A-SAA and hs-CRP and suggest a potential causal link via postchallenge hyperglycemia...
  2. doi request reprint Cardiac troponin T measured by a high-sensitivity assay predicts recurrent cardiovascular events in stable coronary heart disease patients with 8-year follow-up
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Centre, Ulm, Germany
    Clin Chem 58:1215-24. 2012
    ..The clinical relevance of slightly increased circulating troponin concentrations in patients with stable coronary heart disease (CHD) several weeks after an acute event or CABG has not been fully evaluated...
  3. doi request reprint Variability of fibrinogen measurements in post-myocardial infarction patients. Results from the AIRGENE study center Augsburg
    Jens Baumert
    Institute of Epidemiology II, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Thromb Haemost 107:895-902. 2012
    ..The present study indicates a fairly good reproducibility of serial individual fibrinogen measurements in post-MI subjects...
  4. pmc Short-term effects of air pollution: a panel study of blood markers in patients with chronic pulmonary disease
    Katharina Hildebrandt
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Epidemiology, Munich, Germany
    Part Fibre Toxicol 6:25. 2009
    ..abstract:..
  5. pmc Overweight, physical activity, tobacco and alcohol consumption in a cross-sectional random sample of German adults
    Mark M Haenle
    Department of Internal Medicine I, University Hospital Ulm, Robert Koch Str, 8, 89081 Ulm, Germany
    BMC Public Health 6:233. 2006
    ..Data on health behaviour were collected as part of the EMIL study which investigated the prevalence of infection with Echinococcus multilocularis and other medical conditions in an urban German population...
  6. pmc Association between variations in the TLR4 gene and incident type 2 diabetes is modified by the ratio of total cholesterol to HDL-cholesterol
    Melanie Kolz
    Institute of Epidemiology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany
    BMC Med Genet 9:9. 2008
    ..Since several studies have suggested that type 2 diabetes might be associated with changes in the innate immune response, we sought to investigate the association between genetic variants in the TLR4 gene and incident type 2 diabetes...
  7. ncbi request reprint Biomarkers of atherosclerotic plaque instability and rupture
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Robert Koch Str 8, D 89081 Ulm, Germany
    Arterioscler Thromb Vasc Biol 27:15-26. 2007
    ..However, for most of these biomarkers the clinical utility has not yet been established...
  8. doi request reprint Update on integrated biomarkers for assessment of long-term risk of cardiovascular complications in initially healthy subjects and patients with manifest atherosclerosis
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Albert Einstein Allee 23, Ulm, Germany
    Ann Med 41:332-43. 2009
    ....
  9. doi request reprint Integrating biomarkers: the new frontier?
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Scand J Clin Lab Invest Suppl 242:117-23. 2010
    ....
  10. doi request reprint Lipoprotein-associated and secretory phospholipase A2 in cardiovascular disease: the epidemiological evidence
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Albert Einstein Allee, 23, 89081, Ulm, Germany
    Cardiovasc Drugs Ther 23:85-92. 2009
    ..Moreover, Lp-PLA(2) might have similar predictive power for both, incident CHD in initially healthy subjects, as well as for recurrent events in those with clinically manifest atherosclerosis...
  11. ncbi request reprint Serum concentrations of adiponectin and risk of type 2 diabetes mellitus and coronary heart disease in apparently healthy middle-aged men: results from the 18-year follow-up of a large cohort from southern Germany
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    J Am Coll Cardiol 48:1369-77. 2006
    ....
  12. doi request reprint Association between type II secretory phospholipase A2 plasma concentrations and activity and cardiovascular events in patients with coronary heart disease
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Albert Einstein Allee 23, Ulm, Germany
    Eur Heart J 30:2742-8. 2009
    ..We sought to evaluate whether systemic sPLA(2) is associated with prognosis in patients with coronary heart disease (CHD)...
  13. pmc Rosuvastatin for primary prevention in patients with European systematic coronary risk evaluation risk ≥ 5% or Framingham risk >20%: post hoc analyses of the JUPITER trial requested by European health authorities
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Albert Einstein Allee 23, Ulm, Germany
    Eur Heart J 32:75-83. 2011
    ..However, as these are post hoc analyses, data describing these subgroups have not previously been available to the clinical community...
  14. ncbi request reprint Prospective study of high-sensitivity C-reactive protein as a determinant of mortality: results from the MONICA/KORA Augsburg Cohort Study, 1984-1998
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Clin Chem 54:335-42. 2008
    ..Because other chronic diseases are also associated with an inflammatory response, we sought to assess the association of high-sensitivity CRP (hsCRP) with total and cause-specific mortality in a large cohort of middle-aged men...
  15. ncbi request reprint Effect of rosiglitazone treatment on soluble CD40L in patients with type 2 diabetes and coronary artery disease
    Nikolaus Marx
    Department of Internal Medicine II Cardiology, University of Freiburg, Germany
    Circulation 107:1954-7. 2003
    ....
  16. ncbi request reprint Lipoprotein-associated phospholipase A2 adds to risk prediction of incident coronary events by C-reactive protein in apparently healthy middle-aged men from the general population: results from the 14-year follow-up of a large cohort from southern Germany
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Robert Koch Strasse 8, D 89081 Ulm, Germany
    Circulation 110:1903-8. 2004
    ..Chronic inflammation represents an essential feature of the atherosclerotic process. Lipoprotein-associated phospholipase A2 (Lp-PLA2), an enzyme mainly produced by monocytes/macrophages, generates potent proinflammatory products...
  17. doi request reprint Rapid effect of single-dose rosiglitazone treatment on endothelial function in healthy men with normal glucose tolerance: data from a randomised, placebo-controlled, double-blind study
    Thomas Walcher
    Department of Internal Medicine II Cardiology, University of Ulm, Germany
    Diab Vasc Dis Res 7:178-85. 2010
    ....
  18. pmc Vitamin C supplement use may protect against gallstones: an observational study on a randomly selected population
    Thomas Walcher
    Department of Internal Medicine I, University Hospital Ulm, Ulm, Germany
    BMC Gastroenterol 9:74. 2009
    ..The aim of this study was to assess the possible association of regular vitamin C supplementation with gallstone prevalence...
  19. ncbi request reprint Lipoprotein-associated phospholipase A2 predicts future cardiovascular events in patients with coronary heart disease independently of traditional risk factors, markers of inflammation, renal function, and hemodynamic stress
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Robert Koch Str 8, D 89081 Ulm, Germany
    Arterioscler Thromb Vasc Biol 26:1586-93. 2006
    ..We sought to evaluate whether lipoprotein-associated phospholipase A2 (Lp-PLA2), an emerging marker of cardiovascular risk, is associated with prognosis in patients with coronary heart disease (CHD)...
  20. ncbi request reprint Plasma lipoprotein Lp(a), markers of haemostasis and inflammation, and risk and severity of coronary heart disease
    Armin Imhof
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Eur J Cardiovasc Prev Rehabil 10:362-70. 2003
    ..Little is known about potential atherothrombogenic mechanisms of Lp(a)...
  21. ncbi request reprint Increased concentrations of C-reactive protein and IL-6 but not IL-18 are independently associated with incident coronary events in middle-aged men and women: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Arterioscler Thromb Vasc Biol 26:2745-51. 2006
    ....
  22. doi request reprint Low levels of serum 25-hydroxyvitamin D are associated with increased risk of myocardial infarction, especially in women: results from the MONICA/KORA Augsburg case-cohort study
    Mahir Karakas
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Albert Einstein Allee 23, D 89081 Ulm, Germany
    J Clin Endocrinol Metab 98:272-80. 2013
    ..Therefore, we thought to prospectively assess the association between serum 25-hydroxyvitamin D, the most commonly used index of vitamin D status, and incident coronary heart disease...
  23. doi request reprint Associations of adipokines with asthma, rhinoconjunctivitis, and eczema in German schoolchildren
    Gabriele Nagel
    Institute of Epidemiology, Ulm University, Ulm, Germany
    Pediatr Allergy Immunol 20:81-8. 2009
    ..These results suggest that adipokines may contribute to increased asthma and allergy risk in obese subjects. Stronger associations among girls with non-atopic asthma may indicate diverse pathological mechanisms...
  24. ncbi request reprint Association between Lp-PLA2 and coronary artery disease: focus on its relationship with lipoproteins and markers of inflammation and hemostasis
    Natalie Khuseyinova
    Department of Internal Medicine II, Cardiology, University of Ulm Medical Center, Robert Koch Str 8, D 89081 Ulm, Germany
    Atherosclerosis 182:181-8. 2005
    ..12-3.28). Thus, elevated Lp-PLA2 concentrations were associated with the presence of stable CAD, independent of various biochemical markers. Our results support the hypothesis that Lp-PLA2 may be a novel, independent risk marker for CAD...
  25. doi request reprint Association of objectively measured physical activity with established and novel cardiovascular biomarkers in elderly subjects: every step counts
    Jochen Klenk
    Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany
    J Epidemiol Community Health 67:194-7. 2013
    ..To analyse the relationship between objectively measured daily walking duration and cardiovascular biomarkers of inflammation, cardiac dysfunction and renal impairment...
  26. doi request reprint Leptin, adiponectin, their ratio and risk of Coronary Heart Disease: results from the MONICA/KORA Augsburg Study 1984-2002
    Mahir Karakas
    University of Ulm Medical Center, Department of Internal Medicine II Cardiology, Albert Einstein Allee 23, Ulm, Germany
    Atherosclerosis 209:220-5. 2010
    ....
  27. ncbi request reprint Prevalence and cluster of cardiometabolic biomarkers in overweight and obese schoolchildren: results from a large survey in southwest Germany
    Gabriele Nagel
    Institute of Epidemiology, Ulm University, Ulm, Germany
    Clin Chem 54:317-25. 2008
    ..Obesity is associated with substantial metabolic changes and subclinical inflammation. We explored associations between body mass index (BMI) and cardiometabolic biomarkers and their clustering in overweight and obese schoolchildren...
  28. ncbi request reprint C-reactive protein modulates risk prediction based on the Framingham Score: implications for future risk assessment: results from a large cohort study in southern Germany
    Wolfgang Koenig
    Department of Internal Medicine II, Cardiology, University of Ulm Medical Center, Robert Koch Str 8, D 89081 Ulm, Germany
    Circulation 109:1349-53. 2004
    ..We sought to assess the potential of CRP measurements to enhance risk prediction based on the Framingham Risk Score (FRS) in a large cohort of middle-aged men from the general population...
  29. ncbi request reprint Antidiabetic PPAR gamma-activator rosiglitazone reduces MMP-9 serum levels in type 2 diabetic patients with coronary artery disease
    Nikolaus Marx
    Department of Internal Medicine II Cardiology, University of Ulm, Germany
    Arterioscler Thromb Vasc Biol 23:283-8. 2003
    ....
  30. pmc Effect of drinking on adiponectin in healthy men and women: a randomized intervention study of water, ethanol, red wine, and beer with or without alcohol
    Armin Imhof
    Department of Internal Medicine II, Cardiology, University of Ulm, Ulm, Germany
    Diabetes Care 32:1101-3. 2009
    ..Moderate alcohol consumption is associated with reduced incidence of type 2 diabetes and cardiovascular mortality and increases adiponectin concentrations, but effects might differ according to sex and beverage consumed...
  31. doi request reprint Association of proinsulin and hepatic steatosis in a random, population-based sample
    Sonja Wengert
    Department of Internal Medicine I, University Hospital Ulm, Albert Einstein Allee 23, D 89081 Ulm, Germany
    Eur J Endocrinol 168:195-202. 2013
    ..The objective of this study was to investigate the association between hepatic steatosis, proinsulin and other parameters in a random, population-based sample...
  32. ncbi request reprint Association study between variants in the fibrinogen gene cluster, fibrinogen levels and hypertension: results from the MONICA/KORA study
    Melanie Kolz
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Robert Koch Str 8, D 89081 Ulm, Germany
    Thromb Haemost 101:317-24. 2009
    ..In addition, one FGA promoter variant was significantly associated with hypertension in women. Confirmation of these findings by future studies is warranted...
  33. pmc Genetic variation in Fc gamma receptor IIa and risk of coronary heart disease: negative results from two large independent populations
    Mahir Karakas
    Department of Internal Medicine II Cardiology, University of Ulm, Germany
    BMC Med Genet 10:46. 2009
    ..We sought to investigate the association of Fc gamma RIIa genotype with risk of coronary heart disease (CHD) in two large population-based samples...
  34. doi request reprint Oxidized LDL and the risk of coronary heart disease: results from the MONICA/KORA Augsburg Study
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Clin Chem 57:1196-200. 2011
    ..Oxidized LDL (oxLDL) is a marker of oxidative stress. We prospectively investigated whether increased serum oxLDL concentrations are associated with incident coronary heart disease (CHD)...
  35. doi request reprint Reproducibility in serial C-reactive protein and interleukin-6 measurements in post-myocardial infarction patients: results from the AIRGENE study
    Mahir Karakas
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Clin Chem 56:861-4. 2010
    ..Implementation of hsCRP and IL-6 measurement into clinical practice requires data on the reliability of such measurements...
  36. doi request reprint Impact of pioglitazone on coronary endothelial function in non-diabetic patients with coronary artery disease
    Jochen Wohrle
    Department of Internal Medicine II, University of Ulm, Ulm, Germany
    Clin Res Cardiol 97:726-33. 2008
    ..We studied the hypothesis that pioglitazone improves coronary endothelial dysfunction in non-diabetic patients with coronary artery disease (CAD) in a randomized, placebo-controlled, double-blind trial...
  37. pmc A variant in the ABO gene explains the variation in soluble E-selectin levels-results from dense genotyping in two independent populations
    Mahir Karakas
    Department of Internal Medicine II Cardiology, University of Ulm Medical Centre, Ulm, Germany
    PLoS ONE 7:e51441. 2012
    ..Recently, genetic variants in the ABO blood group have been related to E-selectin levels in a small cohort of patients with type 1 diabetes. We evaluated whether this association is reproducible in two large samples of Caucasians...
  38. ncbi request reprint Variability of serial lipoprotein-associated phospholipase A2 measurements in post myocardial infarction patients: results from the AIRGENE Study Center Augsburg
    Natalie Khuseyinova
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Clin Chem 54:124-30. 2008
    ..Implementation of Lp-PLA(2) measurement into clinical practice, however, requires data on the reliability of such measurements...
  39. ncbi request reprint Independent association of various smoking characteristics with markers of systemic inflammation in men. Results from a representative sample of the general population (MONICA Augsburg Survey 1994/95)
    Margit Fröhlich
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Eur Heart J 24:1365-72. 2003
    ..Aim of the study was to investigate the association between various markers of systemic inflammation and a detailed history of smoking in a large representative sample of the general population...
  40. ncbi request reprint Rapid effects of rosiglitazone treatment on endothelial function and inflammatory biomarkers
    Jurgen Hetzel
    Department of Internal Medicine II Cardiology, University of Ulm, Ulm, Germany
    Arterioscler Thromb Vasc Biol 25:1804-9. 2005
    ..Therefore, the present study examined whether short-term rosiglitazone treatment influences endothelium-dependent vasodilation as well as serum levels of vascular disease biomarkers in healthy, nondiabetic subjects...
  41. pmc Prevalence and determinants of chronic kidney disease in community-dwelling elderly by various estimating equations
    Dietrich Rothenbacher
    Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Helmholtzstr 22, D 89081, Germany
    BMC Public Health 12:343. 2012
    ..Few data exist in the elderly. The objective of the current study is to estimate the prevalence of CKD by means of various established and new equations and to identify the main determinants of CKD in elderly...
  42. pmc Relationship between inflammatory cytokines and uric acid levels with adverse cardiovascular outcomes in patients with stable coronary heart disease
    Dietrich Rothenbacher
    Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany
    PLoS ONE 7:e45907. 2012
    ..The aim of the project is to investigate the independent prognostic relationship of inflammatory markers and SUA levels with adverse cardiovascular outcomes in a patient population with stable coronary heart disease (CHD)...
  43. ncbi request reprint Refinement of the association of serum C-reactive protein concentration and coronary heart disease risk by correction for within-subject variation over time: the MONICA Augsburg studies, 1984 and 1987
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Robert Koch Strasse 8, D 89081 Ulm, Germany
    Am J Epidemiol 158:357-64. 2003
    ..The results suggest that the true association between C-reactive protein and cardiovascular risk is underestimated by a single C-reactive protein determination, and that several serial C-reactive protein measurements should be taken...
  44. ncbi request reprint Pioglitazone reduces neointima volume after coronary stent implantation: a randomized, placebo-controlled, double-blind trial in nondiabetic patients
    Nikolaus Marx
    Department of Internal Medicine II, Cardiology, University of Ulm, Ulm, Germany
    Circulation 112:2792-8. 2005
    ..In a randomized, placebo-controlled, double-blind trial, we examined the effect of 6-month pioglitazone therapy on neointima volume after coronary stenting in nondiabetic coronary artery disease patients...
  45. ncbi request reprint Prevalence of non-alcoholic fatty liver and characteristics in overweight adolescents in the general population
    Armin Imhof
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Germany
    Eur J Epidemiol 22:889-97. 2007
    ....
  46. ncbi request reprint Plasminogen levels and risk of coronary artery disease
    Albrecht Hoffmeister
    Department of Internal Medicine II Cardiology, University of Ulm, Robert Koch Strasse 8, D 89081 Ulm, Germany
    Am J Cardiol 90:1168-70. 2002
  47. ncbi request reprint Determination of C-reactive protein: comparison of three high-sensitivity immunoassays
    Natalie Khuseyinova
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Robert Koch Strasse 8, D 89081 Ulm, Germany
    Clin Chem 49:1691-5. 2003
  48. doi request reprint Association of apolipoproteins with symptoms of asthma and atopy among schoolchildren
    Gabriele Nagel
    Institute of Epidemiology, Ulm University, Ulm, Germany
    Int Arch Allergy Immunol 149:259-66. 2009
    ..We explored the associations between serum apolipoprotein concentrations and symptoms of asthma and atopy...
  49. ncbi request reprint Markers of inflammation in women on different hormone replacement therapies
    Margit Fröhlich
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Ann Med 35:353-61. 2003
    ..To measure inflammatory markers in postmenopausal women on different forms of hormone replacement therapy (HRT)...
  50. doi request reprint Seasonality of vitamin D status in older people in Southern Germany: implications for assessment
    Jochen Klenk
    Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany
    Age Ageing 42:404-8. 2013
    ..Therefore, the aim of this study was to analyse the effects of seasonal conditions on 25-hydroxyvitamin D (25(OH)D) serum levels in a population-based cohort of older people...
  51. doi request reprint Copeptin does not add diagnostic information to high-sensitivity troponin T in low- to intermediate-risk patients with acute chest pain: results from the rule out myocardial infarction by computed tomography (ROMICAT) study
    Mahir Karakas
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Clin Chem 57:1137-45. 2011
    ....
  52. ncbi request reprint CD14 C(-260)-->T polymorphism, plasma levels of the soluble endotoxin receptor CD14, their association with chronic infections and risk of stable coronary artery disease
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    J Am Coll Cardiol 40:34-42. 2002
    ..We sought to investigate the association of CD14 genotype and plasma levels of soluble (s)CD14 with risk of stable coronary artery disease (CAD), chronic infections and sensitive markers of systemic inflammation...
  53. doi request reprint Drinking modulates monocyte migration in healthy subjects: a randomised intervention study of water, ethanol, red wine and beer with or without alcohol
    Armin Imhof
    Department of Internal Medicine II, Cardiology, University of Ulm, Ulm, Medical Centre, Robert Koch Strasse 8, D 89081 Ulm, Germany
    Diab Vasc Dis Res 5:48-53. 2008
    ..Short-term intervention with moderate amounts of ethanol and de-alcoholised red wine inhibits monocyte migration ex vivo. This might represent one mechanism by which alcoholic beverages lower cardiovascular risk...
  54. doi request reprint CRP in cardiovascular disease
    Mahir Karakas
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Herz 34:607-13. 2009
    ..JUPITER has revitalized the discussion on CRP in clinical practice and will make it more difficult in the future to neglect the evidence built around CRP and cardiovascular risk...
  55. ncbi request reprint Biomarkers of outcome from cardiovascular disease
    Natalie Khuseyinova
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Curr Opin Crit Care 12:412-9. 2006
    ..We highlight recent epidemiological and experimental evidence concerning four emerging biomarkers: C-reactive protein, interleukin-6, D-dimer and white blood cell count...
  56. ncbi request reprint Plasma concentrations of cystatin C in patients with coronary heart disease and risk for secondary cardiovascular events: more than simply a marker of glomerular filtration rate
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Clin Chem 51:321-7. 2005
    ..We evaluated the impact of cystatin C and other markers of RI on prognosis in a large cohort of patients with coronary heart disease (CHD)...
  57. ncbi request reprint Predicting risk and treatment benefit in atherosclerosis: the role of C-reactive protein
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Robert Koch Strasse 8, D 89081 Ulm, Germany
    Int J Cardiol 98:199-206. 2005
    ....
  58. ncbi request reprint Alcohol inflammation and coronary heart disease
    Armin Imhof
    Department of Internal Medicine II Cardiology, University of Ulm Medical Centre, Ulm, Germany
    Addict Biol 8:271-7. 2003
    ....
  59. ncbi request reprint Periodontal infections and coronary heart disease: role of periodontal bacteria and importance of total pathogen burden in the Coronary Event and Periodontal Disease (CORODONT) study
    Axel Spahr
    Department of Operative Dentistry and Periodontology, University of Ulm Medical Center, Ulm, Germany
    Arch Intern Med 166:554-9. 2006
    ..Periodontitis is a possible trigger of chronic inflammation. We investigated the possible association between periodontitis and coronary heart disease (CHD), focusing on microbiological aspects...
  60. ncbi request reprint Acute-phase reactants and coronary heart disease
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Semin Vasc Med 2:417-28. 2002
    ..However, further studies are required to address these associations because the mechanisms that cause an inflammatory response are only incompletely understood and deserve further investigation...
  61. doi request reprint Effect of blood glucose concentrations on admission in non-diabetic versus diabetic patients with first acute myocardial infarction on short- and long-term mortality (from the MONICA/KORA Augsburg Myocardial Infarction Registry)
    Judith A Beck
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Am J Cardiol 104:1607-12. 2009
    ..These patients constitute a high-risk group needing aggressive, comprehensive polypharmacotherapy...
  62. pmc Effect of serum 25-hydroxyvitamin D on risk for type 2 diabetes may be partially mediated by subclinical inflammation: results from the MONICA/KORA Augsburg study
    Barbara Thorand
    Institute of Epidemiology II, German Research Center for Environmental Health, Neuherberg, Germany
    Diabetes Care 34:2320-2. 2011
    ..To assess the association between serum 25-hydroxyvitamin D (25-OHD) and incident type 2 diabetes and to determine whether the association is mediated by subclinical inflammation...
  63. doi request reprint Angiographic results of a Tacrolimus-eluting stent in acute coronary syndrome lesions
    Angelika Rinker
    Department of Internal Medicine II, University of Ulm, Albert Einstein Allee 23, 89081 Ulm, Germany
    Clin Res Cardiol 98:89-93. 2009
    ....
  64. ncbi request reprint Predicting the risk of cardiovascular disease: where does lipoprotein-associated phospholipase A(2) fit in?
    Natalie Khuseyinova
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Mol Diagn Ther 11:203-17. 2007
    ....
  65. ncbi request reprint Apolipoprotein A-I and risk for cardiovascular diseases
    Natalie Khuseyinova
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Robert Koch Strasse 8, D 89081 Ulm, Germany
    Curr Atheroscler Rep 8:365-73. 2006
    ..This review summarizes our current knowledge based on observations from recent studies, with emphasis on potential pathophysiologic mechanisms of action and on the clinical utility of apoA-I as a predictor of cardiovascular risk...
  66. ncbi request reprint Pregnancy is not a risk factor for gallstone disease: results of a randomly selected population sample
    Thomas Walcher
    University Hospital Ulm, Department of Internal Medicine I, Robert Koch Str 8, D 89081 Ulm, Germany
    World J Gastroenterol 11:6800-6. 2005
    ..To investigate the prevalence, risk factors, and selection of the study population for cholecystolithiasis in an urban population in Germany, in relation to our own findings and to the results in the international literature...
  67. ncbi request reprint Lack of seasonal variation in C-reactive protein
    Margit Fröhlich
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, D 89081 Ulm, Germany
    Clin Chem 48:575-7. 2002
  68. ncbi request reprint Varespladib methyl, an oral phospholipase A2 inhibitor for the potential treatment of coronary artery disease
    Mahir Karakas
    University of Ulm Medical Center, Department of Internal Medicine II Cardiology, Albert Einstein Allee 23, D 89081 Ulm, Germany
    IDrugs 12:585-92. 2009
    ....
  69. ncbi request reprint Fibrin(ogen) in cardiovascular disease: an update
    Wolfgang Koenig
    Dept of Internal Medicine II Cardiology, University of Ulm Medical Center, Robert Koch Str 8, D 89081 Ulm Germany
    Thromb Haemost 89:601-9. 2003
    ....
  70. doi request reprint Myeloperoxidase production by macrophage and risk of atherosclerosis
    Mahir Karakas
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Germany
    Curr Atheroscler Rep 14:277-83. 2012
    ....
  71. ncbi request reprint PPAR activators as antiinflammatory mediators in human T lymphocytes: implications for atherosclerosis and transplantation-associated arteriosclerosis
    Nikolaus Marx
    Department of Internal Medicine II, University of Ulm, Ulm, Germany
    Circ Res 90:703-10. 2002
    ....
  72. ncbi request reprint A case of sudden cardiac death due to isolated eosinophilic coronary arteritis
    Philipp M Lepper
    Department of Internal Medicine II, University of Ulm, Robert Koch Str 8, 89081 Ulm, Germany
    Chest 128:1047-50. 2005
    ..To the best of our knowledge, this is the first case of spontaneous coronary dissection involving all coronary arteries without a history of Churg-Strauss syndrome or hypereosinophilic syndrome...
  73. ncbi request reprint Biomarkers for mortality and cardiovascular events
    Wolfgang Koenig
    JAMA 294:303; author reply 303-4. 2005
  74. ncbi request reprint C-reactive protein as a predictor for incident diabetes mellitus among middle-aged men: results from the MONICA Augsburg cohort study, 1984-1998
    Barbara Thorand
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Arch Intern Med 163:93-9. 2003
    ..Previous studies have suggested that low-grade systemic inflammation is involved in the pathogenesis of type 2 diabetes mellitus...
  75. ncbi request reprint Sex differences in the relation of body composition to markers of inflammation
    Barbara Thorand
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Atherosclerosis 184:216-24. 2006
    ..It has been suggested that low-grade systemic inflammation is associated with obesity and that this association might be modified by sex...
  76. ncbi request reprint C-reactive protein and cardiovascular risk: an update on what is going on in cardiology
    Wolfgang Koenig
    Nephrol Dial Transplant 18:1039-41. 2003
  77. ncbi request reprint Critical evaluation of models to identify individuals with insulin resistance
    Wolfgang Rathmann
    Diabetes Care 28:1833. 2005
  78. ncbi request reprint Influence of depressive mood on the association of CRP and obesity in 3205 middle aged healthy men
    Karl Heinz Ladwig
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Ingolstadter Landstr 1, Neuherberg 85764, Germany
    Brain Behav Immun 17:268-75. 2003
    ..These findings suggest a possible synergistic effect of obesity and depressive mood on chronic low level inflammation which may play a crucial role in the pathogenesis of atherosclerosis...
  79. ncbi request reprint C-reactive protein risk prediction: low specificity, high sensitivity
    Wolfgang Koenig
    Ann Intern Med 136:550-2. 2002
  80. ncbi request reprint Prognostic value of apolipoprotein B and A-I in the prediction of myocardial infarction in middle-aged men and women: results from the MONICA/KORA Augsburg cohort study
    Christa Meisinger
    Central Hospital of Augsburg, MONICA KORA Myocardial Infarction Registry, Augsburg, Germany
    Eur Heart J 26:271-8. 2005
    ..To investigate the association between apolipoprotein B (apoB), A-I (apoA-I), the apoB/apoA-I ratio, and the incidence of coronary events...
  81. ncbi request reprint From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part II
    Morteza Naghavi
    The Center for Vulnerable Plaque Research, University of Texas Houston, The Texas Heart Institute, and President Bush Center for Cardiovascular Health, Memorial Hermann Hospital, Houston, USA
    Circulation 108:1772-8. 2003
    ..We encourage healthcare policy makers to promote translational research for screening and treatment of vulnerable patients...
  82. ncbi request reprint CDC/AHA Workshop on Markers of Inflammation and Cardiovascular Disease: Application to Clinical and Public Health Practice: report from the clinical practice discussion group
    Sidney C Smith
    Circulation 110:e550-3. 2004
  83. ncbi request reprint The endotoxin receptor TLR4 polymorphism is not associated with diabetes or components of the metabolic syndrome
    Thomas Illig
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Diabetes 52:2861-4. 2003
  84. ncbi request reprint C-reactive protein and coronary heart disease
    Paul M Ridker
    N Engl J Med 351:295-8; author reply 295-8. 2004
  85. ncbi request reprint Third generation oral contraceptive use and cardiovascular risk factors
    Angela Doring
    GSF Research, National Research Centre for Environment and Health, Institute of Epidemiology, Ingolstadter Landstr 1, Neuherberg 85764, Germany
    Atherosclerosis 172:281-6. 2004
    ..To analyze the relationship between third generation oral contraceptive (OC) use and various cardiovascular risk factors--including markers of inflammation--in a population-based sample...
  86. ncbi request reprint C-reactive protein, depressed mood, and the prediction of coronary heart disease in initially healthy men: results from the MONICA-KORA Augsburg Cohort Study 1984-1998
    Karl Heinz Ladwig
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Ingolstadter Landstr 1, 85764 Neuherberg, Germany
    Eur Heart J 26:2537-42. 2005
    ..The goal of the present study was to assess possible combined effects of these factors on the prediction of a future fatal and non-fatal coronary event...
  87. ncbi request reprint Is inflammation a causal chain between low socioeconomic status and type 2 diabetes? Results from the KORA Survey 2000
    Wolfgang Rathmann
    Institute of Biometrics and Epidemiology, German Diabetes Center, Leibniz Institute at the Heinrich Heine University, Dusseldorf, Germany
    Eur J Epidemiol 21:55-60. 2006
    ..In conclusion, inflammation appears not to play a major role linking low SES and type 2 diabetes in the elderly population...
  88. ncbi request reprint Cardiovascular biomarkers: added value with an integrated approach?
    Wolfgang Koenig
    Circulation 116:3-5. 2007
  89. ncbi request reprint Ambient source-specific particles are associated with prolonged repolarization and increased levels of inflammation in male coronary artery disease patients
    Wei Yue
    Institute of Epidemiology, GSF National Research Center for Environment and Health, Neuherberg, Germany
    Mutat Res 621:50-60. 2007
    ..These results suggest that traffic-related and combustion-generated particles show stronger adverse health impact with regard to cardiac effects, and that particles from different sources induce an acute phase response in these patients...
  90. ncbi request reprint Sex differences in the prediction of type 2 diabetes by inflammatory markers: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002
    Barbara Thorand
    Institute of Epidemiology, GSF National Research Center for Environment and Health, Neuherberg, Germany
    Diabetes Care 30:854-60. 2007
    ..Therefore, the aim of this study was to compare associations of markers of inflammation with type 2 diabetes risk between men and women...
  91. ncbi request reprint Association of systemic concentrations of macrophage migration inhibitory factor with impaired glucose tolerance and type 2 diabetes: results from the Cooperative Health Research in the Region of Augsburg, Survey 4 (KORA S4)
    Christian Herder
    German Diabetes Clinic, German Diabetes Center, Leibniz Center at Heinrich Heine University, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Diabetes Care 29:368-71. 2006
    ....
  92. ncbi request reprint Systemic monocyte chemoattractant protein-1 concentrations are independent of type 2 diabetes or parameters of obesity: results from the Cooperative Health Research in the Region of Augsburg Survey S4 (KORA S4)
    Christian Herder
    German Diabetes Clinic, German Diabetes Centre, Leibniz Centre at Heinrich Heine University, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Eur J Endocrinol 154:311-7. 2006
    ..Since MCP-1 is produced by adipocytes and has been postulated to be involved in macrophage infiltration into adipose tissue, we wanted to test whether serum MCP-1 levels were correlated with T2D or obesity...
  93. ncbi request reprint Association of cardiovascular risk factors with markers of endothelial dysfunction in middle-aged men and women. Results from the MONICA/KORA Augsburg Study
    Barbara Thorand
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Thromb Haemost 95:134-41. 2006
    ..VWF was significantly associated with CRP only. In conclusion, sE-selectin and sICAM-1 are more strongly associated with traditional cardiovascular risk factors than sTM and vWF...
  94. ncbi request reprint C-reactive protein and cardiovascular risk in the Framingham Study
    Paul Ridker
    Arch Intern Med 166:1327-8; author reply 1328. 2006
  95. ncbi request reprint Systemic immune mediators and lifestyle changes in the prevention of type 2 diabetes: results from the Finnish Diabetes Prevention Study
    Christian Herder
    German Diabetes Clinic, German Diabetes Center, Leibniz Center at Heinrich Heine University Düsseldorf, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Diabetes 55:2340-6. 2006
    ..088). Thus, systemic concentrations of immune mediators appear to be associated with the progression to type 2 diabetes and the prevention of type 2 diabetes by lifestyle changes...
  96. ncbi request reprint Association of systemic chemokine concentrations with impaired glucose tolerance and type 2 diabetes: results from the Cooperative Health Research in the Region of Augsburg Survey S4 (KORA S4)
    Christian Herder
    German Diabetes Clinic, German Diabetes Center, Leibniz Institute at Heinrich Heine University, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Diabetes 54:S11-7. 2005
    ..There is no general upregulation of chemokine production in type 2 diabetes, but rather an association of the disease with specific members of the chemokine family...
  97. ncbi request reprint Uric acid, type 2 diabetes, and cardiovascular diseases: fueling the common soil hypothesis?
    Wolfgang Koenig
    Clin Chem 54:231-3. 2008
  98. doi request reprint RANTES/CCL5 gene polymorphisms, serum concentrations, and incident type 2 diabetes: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002
    Christian Herder
    Institute for Clinical Diabetes Research, German Diabetes Centre, Leibniz Institute at Heinrich Heine University, 40225 Dusseldorf, Germany
    Eur J Endocrinol 158:R1-5. 2008
    ....
  99. ncbi request reprint Differential expression of chemokines, risk of stable coronary heart disease, and correlation with established cardiovascular risk markers
    Dietrich Rothenbacher
    Department of Epidemiology, The German Centre for Research on Ageing, University of Heidelberg, Germany
    Arterioscler Thromb Vasc Biol 26:194-9. 2006
    ..Furthermore, we analyzed their correlation with various acute-phase proteins, inflammation-associated cytokines, and an adhesion molecule...
  100. doi request reprint Uric acid levels are associated with all-cause and cardiovascular disease mortality independent of systemic inflammation in men from the general population: the MONICA/KORA cohort study
    Christa Meisinger
    Central Hospital of Augsburg, MONICA KORA Myocardial Infarction Registry, Augsburg, Germany
    Arterioscler Thromb Vasc Biol 28:1186-92. 2008
    ....
  101. ncbi request reprint Elevated markers of endothelial dysfunction predict type 2 diabetes mellitus in middle-aged men and women from the general population
    Barbara Thorand
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Arterioscler Thromb Vasc Biol 26:398-405. 2006
    ....