Wolfgang Koenig

Summary

Affiliation: University of Ulm
Country: Germany

Publications

  1. pmc Effect of serum 25-hydroxyvitamin D on risk for type 2 diabetes may be partially mediated by subclinical inflammation: results from the MONICA/KORA Augsburg study
    Barbara Thorand
    Institute of Epidemiology II, German Research Center for Environmental Health, Neuherberg, Germany
    Diabetes Care 34:2320-2. 2011
  2. pmc A variant in the ABO gene explains the variation in soluble E-selectin levels-results from dense genotyping in two independent populations
    Mahir Karakas
    Department of Internal Medicine II Cardiology, University of Ulm Medical Centre, Ulm, Germany
    PLoS ONE 7:e51441. 2012
  3. pmc Transforming growth factor-beta1 and incident type 2 diabetes: results from the MONICA/KORA case-cohort study, 1984-2002
    Christian Herder
    Institute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Dusseldorf, Germany
    Diabetes Care 32:1921-3. 2009
  4. pmc Immunological and cardiometabolic risk factors in the prediction of type 2 diabetes and coronary events: MONICA/KORA Augsburg case-cohort study
    Christian Herder
    Institute for Clinical Diabetology, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Dusseldorf, Germany
    PLoS ONE 6:e19852. 2011
  5. ncbi request reprint High-sensitivity C-reactive protein and atherosclerotic disease: from improved risk prediction to risk-guided therapy
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Albert Einstein Allee 23, D 89081 Ulm, Germany Electronic address
    Int J Cardiol 168:5126-34. 2013
  6. doi request reprint Cardiac troponin T measured by a high-sensitivity assay predicts recurrent cardiovascular events in stable coronary heart disease patients with 8-year follow-up
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Centre, Ulm, Germany
    Clin Chem 58:1215-24. 2012
  7. pmc Short-term effects of air pollution: a panel study of blood markers in patients with chronic pulmonary disease
    Katharina Hildebrandt
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Epidemiology, Munich, Germany
    Part Fibre Toxicol 6:25. 2009
  8. pmc Overweight, physical activity, tobacco and alcohol consumption in a cross-sectional random sample of German adults
    Mark M Haenle
    Department of Internal Medicine I, University Hospital Ulm, Robert Koch Str, 8, 89081 Ulm, Germany
    BMC Public Health 6:233. 2006
  9. doi request reprint Association between type II secretory phospholipase A2 plasma concentrations and activity and cardiovascular events in patients with coronary heart disease
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Albert Einstein Allee 23, Ulm, Germany
    Eur Heart J 30:2742-8. 2009
  10. pmc Rosuvastatin for primary prevention in patients with European systematic coronary risk evaluation risk ≥ 5% or Framingham risk >20%: post hoc analyses of the JUPITER trial requested by European health authorities
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Albert Einstein Allee 23, Ulm, Germany
    Eur Heart J 32:75-83. 2011

Detail Information

Publications132 found, 100 shown here

  1. pmc Effect of serum 25-hydroxyvitamin D on risk for type 2 diabetes may be partially mediated by subclinical inflammation: results from the MONICA/KORA Augsburg study
    Barbara Thorand
    Institute of Epidemiology II, German Research Center for Environmental Health, Neuherberg, Germany
    Diabetes Care 34:2320-2. 2011
    ..To assess the association between serum 25-hydroxyvitamin D (25-OHD) and incident type 2 diabetes and to determine whether the association is mediated by subclinical inflammation...
  2. pmc A variant in the ABO gene explains the variation in soluble E-selectin levels-results from dense genotyping in two independent populations
    Mahir Karakas
    Department of Internal Medicine II Cardiology, University of Ulm Medical Centre, Ulm, Germany
    PLoS ONE 7:e51441. 2012
    ..Recently, genetic variants in the ABO blood group have been related to E-selectin levels in a small cohort of patients with type 1 diabetes. We evaluated whether this association is reproducible in two large samples of Caucasians...
  3. pmc Transforming growth factor-beta1 and incident type 2 diabetes: results from the MONICA/KORA case-cohort study, 1984-2002
    Christian Herder
    Institute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Dusseldorf, Germany
    Diabetes Care 32:1921-3. 2009
    ..This study aimed to assess whether levels of circulating transforming growth factor-beta1 (TGF-beta1)-a central, mainly immunosuppressive, and anti-inflammatory cytokine-were associated with incident type 2 diabetes...
  4. pmc Immunological and cardiometabolic risk factors in the prediction of type 2 diabetes and coronary events: MONICA/KORA Augsburg case-cohort study
    Christian Herder
    Institute for Clinical Diabetology, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Dusseldorf, Germany
    PLoS ONE 6:e19852. 2011
    ....
  5. ncbi request reprint High-sensitivity C-reactive protein and atherosclerotic disease: from improved risk prediction to risk-guided therapy
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Albert Einstein Allee 23, D 89081 Ulm, Germany Electronic address
    Int J Cardiol 168:5126-34. 2013
    ..If successful, this may become a novel strategy to treat high-risk patients with stable atherosclerotic disease to prevent recurrent events on top of standard medical care. ..
  6. doi request reprint Cardiac troponin T measured by a high-sensitivity assay predicts recurrent cardiovascular events in stable coronary heart disease patients with 8-year follow-up
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Centre, Ulm, Germany
    Clin Chem 58:1215-24. 2012
    ..The clinical relevance of slightly increased circulating troponin concentrations in patients with stable coronary heart disease (CHD) several weeks after an acute event or CABG has not been fully evaluated...
  7. pmc Short-term effects of air pollution: a panel study of blood markers in patients with chronic pulmonary disease
    Katharina Hildebrandt
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Epidemiology, Munich, Germany
    Part Fibre Toxicol 6:25. 2009
    ..abstract:..
  8. pmc Overweight, physical activity, tobacco and alcohol consumption in a cross-sectional random sample of German adults
    Mark M Haenle
    Department of Internal Medicine I, University Hospital Ulm, Robert Koch Str, 8, 89081 Ulm, Germany
    BMC Public Health 6:233. 2006
    ..Data on health behaviour were collected as part of the EMIL study which investigated the prevalence of infection with Echinococcus multilocularis and other medical conditions in an urban German population...
  9. doi request reprint Association between type II secretory phospholipase A2 plasma concentrations and activity and cardiovascular events in patients with coronary heart disease
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Albert Einstein Allee 23, Ulm, Germany
    Eur Heart J 30:2742-8. 2009
    ..We sought to evaluate whether systemic sPLA(2) is associated with prognosis in patients with coronary heart disease (CHD)...
  10. pmc Rosuvastatin for primary prevention in patients with European systematic coronary risk evaluation risk ≥ 5% or Framingham risk >20%: post hoc analyses of the JUPITER trial requested by European health authorities
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Albert Einstein Allee 23, Ulm, Germany
    Eur Heart J 32:75-83. 2011
    ..However, as these are post hoc analyses, data describing these subgroups have not previously been available to the clinical community...
  11. ncbi request reprint Integrating biomarkers: the new frontier?
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Scand J Clin Lab Invest Suppl 242:117-23. 2010
    ..Thus, more data, preferably from serial measurements in large populations taking also into account new candidates from "omics" technology are needed to gain further insight in the potential clinical usefulness of an integrated approach...
  12. ncbi request reprint Prospective study of high-sensitivity C-reactive protein as a determinant of mortality: results from the MONICA/KORA Augsburg Cohort Study, 1984-1998
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Clin Chem 54:335-42. 2008
    ..Because other chronic diseases are also associated with an inflammatory response, we sought to assess the association of high-sensitivity CRP (hsCRP) with total and cause-specific mortality in a large cohort of middle-aged men...
  13. doi request reprint Lipoprotein-associated and secretory phospholipase A2 in cardiovascular disease: the epidemiological evidence
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Albert Einstein Allee, 23, 89081, Ulm, Germany
    Cardiovasc Drugs Ther 23:85-92. 2009
    ..Moreover, Lp-PLA(2) might have similar predictive power for both, incident CHD in initially healthy subjects, as well as for recurrent events in those with clinically manifest atherosclerosis...
  14. doi request reprint Update on integrated biomarkers for assessment of long-term risk of cardiovascular complications in initially healthy subjects and patients with manifest atherosclerosis
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Albert Einstein Allee 23, Ulm, Germany
    Ann Med 41:332-43. 2009
    ....
  15. ncbi request reprint Biomarkers of atherosclerotic plaque instability and rupture
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Robert Koch Str 8, D 89081 Ulm, Germany
    Arterioscler Thromb Vasc Biol 27:15-26. 2007
    ..However, for most of these biomarkers the clinical utility has not yet been established...
  16. ncbi request reprint Serum concentrations of adiponectin and risk of type 2 diabetes mellitus and coronary heart disease in apparently healthy middle-aged men: results from the 18-year follow-up of a large cohort from southern Germany
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    J Am Coll Cardiol 48:1369-77. 2006
    ....
  17. ncbi request reprint Association study between variants in the fibrinogen gene cluster, fibrinogen levels and hypertension: results from the MONICA/KORA study
    Melanie Kolz
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Robert Koch Str 8, D 89081 Ulm, Germany
    Thromb Haemost 101:317-24. 2009
    ..In addition, one FGA promoter variant was significantly associated with hypertension in women. Confirmation of these findings by future studies is warranted...
  18. pmc Subclinical inflammation and diabetic polyneuropathy: MONICA/KORA Survey F3 (Augsburg, Germany)
    Christian Herder
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Dusseldorf, Germany
    Diabetes Care 32:680-2. 2009
    ..Therefore, we investigated whether circulating concentrations of acute-phase proteins, cytokines, and chemokines differ among diabetic patients with or without diabetic polyneuropathy...
  19. ncbi request reprint Increased concentrations of C-reactive protein and IL-6 but not IL-18 are independently associated with incident coronary events in middle-aged men and women: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Arterioscler Thromb Vasc Biol 26:2745-51. 2006
    ....
  20. ncbi request reprint Association of cardiovascular risk factors with markers of endothelial dysfunction in middle-aged men and women. Results from the MONICA/KORA Augsburg Study
    Barbara Thorand
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Thromb Haemost 95:134-41. 2006
    ..VWF was significantly associated with CRP only. In conclusion, sE-selectin and sICAM-1 are more strongly associated with traditional cardiovascular risk factors than sTM and vWF...
  21. ncbi request reprint Elevated markers of endothelial dysfunction predict type 2 diabetes mellitus in middle-aged men and women from the general population
    Barbara Thorand
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Arterioscler Thromb Vasc Biol 26:398-405. 2006
    ....
  22. ncbi request reprint Is inflammation a causal chain between low socioeconomic status and type 2 diabetes? Results from the KORA Survey 2000
    Wolfgang Rathmann
    Institute of Biometrics and Epidemiology, German Diabetes Center, Leibniz Institute at the Heinrich Heine University, Dusseldorf, Germany
    Eur J Epidemiol 21:55-60. 2006
    ..In conclusion, inflammation appears not to play a major role linking low SES and type 2 diabetes in the elderly population...
  23. ncbi request reprint Sex differences in the prediction of type 2 diabetes by inflammatory markers: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002
    Barbara Thorand
    Institute of Epidemiology, GSF National Research Center for Environment and Health, Neuherberg, Germany
    Diabetes Care 30:854-60. 2007
    ..Therefore, the aim of this study was to compare associations of markers of inflammation with type 2 diabetes risk between men and women...
  24. ncbi request reprint Fibrinogen genes modify the fibrinogen response to ambient particulate matter
    Annette Peters
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Epidemiology, Ingolstaedter Landstrasse, Neuherberg 85764, Germany
    Am J Respir Crit Care Med 179:484-91. 2009
    ..Ambient particulate matter has been associated with systemic inflammation indicated by blood markers such as fibrinogen, implicated in promoting atherothrombosis...
  25. ncbi request reprint Association of systemic concentrations of macrophage migration inhibitory factor with impaired glucose tolerance and type 2 diabetes: results from the Cooperative Health Research in the Region of Augsburg, Survey 4 (KORA S4)
    Christian Herder
    German Diabetes Clinic, German Diabetes Center, Leibniz Center at Heinrich Heine University, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Diabetes Care 29:368-71. 2006
    ....
  26. doi request reprint Sfrp5 correlates with insulin resistance and oxidative stress
    Maren Carstensen
    Institute for Clinical Diabetology, German Diabetes Center, Dusseldorf, Germany
    Eur J Clin Invest 43:350-7. 2013
    ..The aim of this study was to compare serum concentrations and determinants of Sfrp5, its pro-inflammatory antagonist wingless-type MMTV integration site family member (Wnt)5a and adiponectin in humans and their regulation by coffee...
  27. ncbi request reprint Effect of rosiglitazone treatment on soluble CD40L in patients with type 2 diabetes and coronary artery disease
    Nikolaus Marx
    Department of Internal Medicine II Cardiology, University of Freiburg, Germany
    Circulation 107:1954-7. 2003
    ....
  28. doi request reprint Macrophage migration inhibitory factor (MIF) and risk for coronary heart disease: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002
    Christian Herder
    Institute for Clinical Diabetes Research, German Diabetes Center, Leibniz Institute at Heinrich Heine University, Dusseldorf, Germany
    Atherosclerosis 200:380-8. 2008
    ....
  29. doi request reprint Determinants of the acute-phase protein C-reactive protein in myocardial infarction survivors: the role of comorbidities and environmental factors
    Regina Ruckerl
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Epidemiology, Munich, Germany
    Clin Chem 55:322-35. 2009
    ..A joint analysis of the role of risk factors in predicting mean concentrations and variation of high-sensitivity CRP (hsCRP) in serum has not been carried out previously...
  30. pmc Association between variations in the TLR4 gene and incident type 2 diabetes is modified by the ratio of total cholesterol to HDL-cholesterol
    Melanie Kolz
    Institute of Epidemiology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany
    BMC Med Genet 9:9. 2008
    ..Since several studies have suggested that type 2 diabetes might be associated with changes in the innate immune response, we sought to investigate the association between genetic variants in the TLR4 gene and incident type 2 diabetes...
  31. ncbi request reprint Lipoprotein-associated phospholipase A2 adds to risk prediction of incident coronary events by C-reactive protein in apparently healthy middle-aged men from the general population: results from the 14-year follow-up of a large cohort from southern Germany
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Robert Koch Strasse 8, D 89081 Ulm, Germany
    Circulation 110:1903-8. 2004
    ..Chronic inflammation represents an essential feature of the atherosclerotic process. Lipoprotein-associated phospholipase A2 (Lp-PLA2), an enzyme mainly produced by monocytes/macrophages, generates potent proinflammatory products...
  32. doi request reprint TGF-β1 content in atherosclerotic plaques, TGF-β1 serum concentrations and incident coronary events
    Christian Herder
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Dusseldorf, Germany
    Eur J Clin Invest 42:329-37. 2012
    ..We tested the hypothesis that high TGF-β1 content in atherosclerotic plaques and high TGF-β1 serum levels are associated with lower risk of coronary events in two independent prospective studies...
  33. ncbi request reprint Systemic immune mediators and lifestyle changes in the prevention of type 2 diabetes: results from the Finnish Diabetes Prevention Study
    Christian Herder
    German Diabetes Clinic, German Diabetes Center, Leibniz Center at Heinrich Heine University Düsseldorf, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Diabetes 55:2340-6. 2006
    ..088). Thus, systemic concentrations of immune mediators appear to be associated with the progression to type 2 diabetes and the prevention of type 2 diabetes by lifestyle changes...
  34. doi request reprint Rapid effect of single-dose rosiglitazone treatment on endothelial function in healthy men with normal glucose tolerance: data from a randomised, placebo-controlled, double-blind study
    Thomas Walcher
    Department of Internal Medicine II Cardiology, University of Ulm, Germany
    Diab Vasc Dis Res 7:178-85. 2010
    ....
  35. ncbi request reprint Elevated levels of interleukin-18 predict the development of type 2 diabetes: results from the MONICA/KORA Augsburg Study, 1984-2002
    Barbara Thorand
    GF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Diabetes 54:2932-8. 2005
    ..This association is independent of a generalized proinflammatory state, but subjects with elevated levels of several inflammatory markers seem to be particularly prone to develop type 2 diabetes...
  36. doi request reprint Short-term effects of air temperature on blood markers of coagulation and inflammation in potentially susceptible individuals
    Claudia Luise Schäuble
    Institute of Epidemiology II, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Occup Environ Med 69:670-8. 2012
    ..The authors investigated the association between air temperature and fibrinogen, plasminogen activator inhibitor type 1, interleukin-6 and high-sensitivity C reactive protein in two potentially susceptible groups...
  37. doi request reprint Low levels of serum 25-hydroxyvitamin D are associated with increased risk of myocardial infarction, especially in women: results from the MONICA/KORA Augsburg case-cohort study
    Mahir Karakas
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Albert Einstein Allee 23, D 89081 Ulm, Germany
    J Clin Endocrinol Metab 98:272-80. 2013
    ..Therefore, we thought to prospectively assess the association between serum 25-hydroxyvitamin D, the most commonly used index of vitamin D status, and incident coronary heart disease...
  38. ncbi request reprint Plasma lipoprotein Lp(a), markers of haemostasis and inflammation, and risk and severity of coronary heart disease
    Armin Imhof
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Eur J Cardiovasc Prev Rehabil 10:362-70. 2003
    ..Little is known about potential atherothrombogenic mechanisms of Lp(a)...
  39. ncbi request reprint C-reactive protein modulates risk prediction based on the Framingham Score: implications for future risk assessment: results from a large cohort study in southern Germany
    Wolfgang Koenig
    Department of Internal Medicine II, Cardiology, University of Ulm Medical Center, Robert Koch Str 8, D 89081 Ulm, Germany
    Circulation 109:1349-53. 2004
    ..We sought to assess the potential of CRP measurements to enhance risk prediction based on the Framingham Risk Score (FRS) in a large cohort of middle-aged men from the general population...
  40. ncbi request reprint Sex differences in the relation of body composition to markers of inflammation
    Barbara Thorand
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Atherosclerosis 184:216-24. 2006
    ..It has been suggested that low-grade systemic inflammation is associated with obesity and that this association might be modified by sex...
  41. doi request reprint Air temperature and inflammatory responses in myocardial infarction survivors
    Alexandra Schneider
    Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany
    Epidemiology 19:391-400. 2008
    ..The objective of this study was to analyze the association between air temperature and C-reactive protein, interleukin-6 and fibrinogen in postmyocardial infarction patients...
  42. ncbi request reprint Hypoadiponectinemia and proinflammatory state: two sides of the same coin?: results from the Cooperative Health Research in the Region of Augsburg Survey 4 (KORA S4)
    Christian Herder
    German Diabetes Clinic, German Diabetes Center, Leibniz Center at Heinrich Heine University, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Diabetes Care 29:1626-31. 2006
    ..The major aim of this cross-sectional study was to investigate the interdependence of hypoadiponectinemia and low-grade systemic inflammation...
  43. ncbi request reprint Air temperature and inflammatory and coagulation responses in men with coronary or pulmonary disease during the winter season
    Regina Hampel
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany
    Occup Environ Med 67:408-16. 2010
    ..We investigated the associations between temperature and several blood markers in patients with coronary heart disease (CHD) and pulmonary disease (PD)...
  44. pmc Vitamin C supplement use may protect against gallstones: an observational study on a randomly selected population
    Thomas Walcher
    Department of Internal Medicine I, University Hospital Ulm, Ulm, Germany
    BMC Gastroenterol 9:74. 2009
    ..The aim of this study was to assess the possible association of regular vitamin C supplementation with gallstone prevalence...
  45. ncbi request reprint Lipoprotein-associated phospholipase A2 predicts future cardiovascular events in patients with coronary heart disease independently of traditional risk factors, markers of inflammation, renal function, and hemodynamic stress
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Robert Koch Str 8, D 89081 Ulm, Germany
    Arterioscler Thromb Vasc Biol 26:1586-93. 2006
    ..We sought to evaluate whether lipoprotein-associated phospholipase A2 (Lp-PLA2), an emerging marker of cardiovascular risk, is associated with prognosis in patients with coronary heart disease (CHD)...
  46. ncbi request reprint Air pollution and inflammatory response in myocardial infarction survivors: gene-environment interactions in a high-risk group
    Annette Peters
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Inhal Toxicol 19:161-75. 2007
    ....
  47. doi request reprint Leptin, adiponectin, their ratio and risk of Coronary Heart Disease: results from the MONICA/KORA Augsburg Study 1984-2002
    Mahir Karakas
    University of Ulm Medical Center, Department of Internal Medicine II Cardiology, Albert Einstein Allee 23, Ulm, Germany
    Atherosclerosis 209:220-5. 2010
    ....
  48. pmc Acute-phase serum amyloid A protein and its implication in the development of type 2 diabetes in the KORA S4/F4 study
    Carola Marzi
    Department of Molecular Epidemiology, German Research Centerfor Environmental Health, Neuherberg, Germany
    Diabetes Care 36:1321-6. 2013
    ..We sought to investigate whether elevated levels of acute-phase serum amyloid A (A-SAA) protein precede the onset of type 2 diabetes independently of other risk factors, including parameters of glucose metabolism...
  49. pmc Genetic variation in Fc gamma receptor IIa and risk of coronary heart disease: negative results from two large independent populations
    Mahir Karakas
    Department of Internal Medicine II Cardiology, University of Ulm, Germany
    BMC Med Genet 10:46. 2009
    ..We sought to investigate the association of Fc gamma RIIa genotype with risk of coronary heart disease (CHD) in two large population-based samples...
  50. doi request reprint Markers of inflammation and weight change in middle-aged adults: results from the prospective MONICA/KORA S3/F3 study
    Thomas Holz
    Helmholtz Zentrum Munchen German Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany
    Obesity (Silver Spring) 18:2347-53. 2010
    ..This suggests that inflammation plays a key role in the process of weight gain, especially after smoking cessation...
  51. ncbi request reprint Prevalence and cluster of cardiometabolic biomarkers in overweight and obese schoolchildren: results from a large survey in southwest Germany
    Gabriele Nagel
    Institute of Epidemiology, Ulm University, Ulm, Germany
    Clin Chem 54:317-25. 2008
    ..Obesity is associated with substantial metabolic changes and subclinical inflammation. We explored associations between body mass index (BMI) and cardiometabolic biomarkers and their clustering in overweight and obese schoolchildren...
  52. doi request reprint Effects of coffee consumption on subclinical inflammation and other risk factors for type 2 diabetes: a clinical trial
    Kerstin Kempf
    Institute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich, Heine University Düsseldorf, Dusseldorf, Germany
    Am J Clin Nutr 91:950-7. 2010
    ..Coffee consumption is associated with a decreased risk of type 2 diabetes. Suggested mechanisms underlying the association have included attenuation of subclinical inflammation and a reduction in oxidative stress...
  53. pmc Immune mediators in patients with acute diabetic foot syndrome
    Christian Weigelt
    Institute for Clinical Diabetology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich Heine University, Dusseldorf, Germany
    Diabetes Care 32:1491-6. 2009
    ..Further studies should investigate whether an activation of the immune system precedes the development of foot ulcer and whether anti-inflammatory therapies might be effective...
  54. doi request reprint Variability of fibrinogen measurements in post-myocardial infarction patients. Results from the AIRGENE study center Augsburg
    Jens Baumert
    Institute of Epidemiology II, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Thromb Haemost 107:895-902. 2012
    ..The present study indicates a fairly good reproducibility of serial individual fibrinogen measurements in post-MI subjects...
  55. ncbi request reprint Association between Lp-PLA2 and coronary artery disease: focus on its relationship with lipoproteins and markers of inflammation and hemostasis
    Natalie Khuseyinova
    Department of Internal Medicine II, Cardiology, University of Ulm Medical Center, Robert Koch Str 8, D 89081 Ulm, Germany
    Atherosclerosis 182:181-8. 2005
    ..12-3.28). Thus, elevated Lp-PLA2 concentrations were associated with the presence of stable CAD, independent of various biochemical markers. Our results support the hypothesis that Lp-PLA2 may be a novel, independent risk marker for CAD...
  56. doi request reprint Associations of adipokines with asthma, rhinoconjunctivitis, and eczema in German schoolchildren
    Gabriele Nagel
    Institute of Epidemiology, Ulm University, Ulm, Germany
    Pediatr Allergy Immunol 20:81-8. 2009
    ..These results suggest that adipokines may contribute to increased asthma and allergy risk in obese subjects. Stronger associations among girls with non-atopic asthma may indicate diverse pathological mechanisms...
  57. doi request reprint Association of proinsulin and hepatic steatosis in a random, population-based sample
    Sonja Wengert
    Department of Internal Medicine I, University Hospital Ulm, Albert Einstein Allee 23, D 89081 Ulm, Germany
    Eur J Endocrinol 168:195-202. 2013
    ..The objective of this study was to investigate the association between hepatic steatosis, proinsulin and other parameters in a random, population-based sample...
  58. ncbi request reprint Variability of serial lipoprotein-associated phospholipase A2 measurements in post myocardial infarction patients: results from the AIRGENE Study Center Augsburg
    Natalie Khuseyinova
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Clin Chem 54:124-30. 2008
    ..Implementation of Lp-PLA(2) measurement into clinical practice, however, requires data on the reliability of such measurements...
  59. ncbi request reprint Job strain associated CRP is mediated by leisure time physical activity: results from the MONICA/KORA study
    Rebecca Emeny
    Institute of Epidemiology II, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, 85764 Neuherberg, Germany
    Brain Behav Immun 26:1077-84. 2012
    ..Secondary analyses explored the role of psychosocial/cardiometabolic risk factors as mediators of job stress associated inflammation in healthy workers...
  60. pmc Effect of drinking on adiponectin in healthy men and women: a randomized intervention study of water, ethanol, red wine, and beer with or without alcohol
    Armin Imhof
    Department of Internal Medicine II, Cardiology, University of Ulm, Ulm, Germany
    Diabetes Care 32:1101-3. 2009
    ..Moderate alcohol consumption is associated with reduced incidence of type 2 diabetes and cardiovascular mortality and increases adiponectin concentrations, but effects might differ according to sex and beverage consumed...
  61. doi request reprint Association between different domains of physical activity and markers of inflammation
    Christine Autenrieth
    Institute of Epidemiology, German Research Center for Environmental Health, Neuherberg, Germany
    Med Sci Sports Exerc 41:1706-13. 2009
    ..Physical activity has recently been established as a potential modifier of the inflammatory process, suggesting that it mitigates inflammation and consequently reduces the incidence of several chronic diseases such as cardiovascular events...
  62. ncbi request reprint Ambient source-specific particles are associated with prolonged repolarization and increased levels of inflammation in male coronary artery disease patients
    Wei Yue
    Institute of Epidemiology, GSF National Research Center for Environment and Health, Neuherberg, Germany
    Mutat Res 621:50-60. 2007
    ..These results suggest that traffic-related and combustion-generated particles show stronger adverse health impact with regard to cardiac effects, and that particles from different sources induce an acute phase response in these patients...
  63. doi request reprint Seasonality of vitamin D status in older people in Southern Germany: implications for assessment
    Jochen Klenk
    Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany
    Age Ageing 42:404-8. 2013
    ..Therefore, the aim of this study was to analyse the effects of seasonal conditions on 25-hydroxyvitamin D (25(OH)D) serum levels in a population-based cohort of older people...
  64. doi request reprint Association of objectively measured physical activity with established and novel cardiovascular biomarkers in elderly subjects: every step counts
    Jochen Klenk
    Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany
    J Epidemiol Community Health 67:194-7. 2013
    ..To analyse the relationship between objectively measured daily walking duration and cardiovascular biomarkers of inflammation, cardiac dysfunction and renal impairment...
  65. ncbi request reprint Antidiabetic PPAR gamma-activator rosiglitazone reduces MMP-9 serum levels in type 2 diabetic patients with coronary artery disease
    Nikolaus Marx
    Department of Internal Medicine II Cardiology, University of Ulm, Germany
    Arterioscler Thromb Vasc Biol 23:283-8. 2003
    ....
  66. doi request reprint Reproducibility in serial C-reactive protein and interleukin-6 measurements in post-myocardial infarction patients: results from the AIRGENE study
    Mahir Karakas
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Clin Chem 56:861-4. 2010
    ..Implementation of hsCRP and IL-6 measurement into clinical practice requires data on the reliability of such measurements...
  67. doi request reprint Oxidized LDL and the risk of coronary heart disease: results from the MONICA/KORA Augsburg Study
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Clin Chem 57:1196-200. 2011
    ..Oxidized LDL (oxLDL) is a marker of oxidative stress. We prospectively investigated whether increased serum oxLDL concentrations are associated with incident coronary heart disease (CHD)...
  68. doi request reprint Impact of pioglitazone on coronary endothelial function in non-diabetic patients with coronary artery disease
    Jochen Wohrle
    Department of Internal Medicine II, University of Ulm, Ulm, Germany
    Clin Res Cardiol 97:726-33. 2008
    ..We studied the hypothesis that pioglitazone improves coronary endothelial dysfunction in non-diabetic patients with coronary artery disease (CAD) in a randomized, placebo-controlled, double-blind trial...
  69. ncbi request reprint Rapid effects of rosiglitazone treatment on endothelial function and inflammatory biomarkers
    Jurgen Hetzel
    Department of Internal Medicine II Cardiology, University of Ulm, Ulm, Germany
    Arterioscler Thromb Vasc Biol 25:1804-9. 2005
    ..Therefore, the present study examined whether short-term rosiglitazone treatment influences endothelium-dependent vasodilation as well as serum levels of vascular disease biomarkers in healthy, nondiabetic subjects...
  70. ncbi request reprint Independent association of various smoking characteristics with markers of systemic inflammation in men. Results from a representative sample of the general population (MONICA Augsburg Survey 1994/95)
    Margit Fröhlich
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Eur Heart J 24:1365-72. 2003
    ..Aim of the study was to investigate the association between various markers of systemic inflammation and a detailed history of smoking in a large representative sample of the general population...
  71. pmc Prevalence and determinants of chronic kidney disease in community-dwelling elderly by various estimating equations
    Dietrich Rothenbacher
    Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Helmholtzstr 22, D 89081, Germany
    BMC Public Health 12:343. 2012
    ..Few data exist in the elderly. The objective of the current study is to estimate the prevalence of CKD by means of various established and new equations and to identify the main determinants of CKD in elderly...
  72. pmc Relationship between inflammatory cytokines and uric acid levels with adverse cardiovascular outcomes in patients with stable coronary heart disease
    Dietrich Rothenbacher
    Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany
    PLoS ONE 7:e45907. 2012
    ..The aim of the project is to investigate the independent prognostic relationship of inflammatory markers and SUA levels with adverse cardiovascular outcomes in a patient population with stable coronary heart disease (CHD)...
  73. ncbi request reprint Pioglitazone reduces neointima volume after coronary stent implantation: a randomized, placebo-controlled, double-blind trial in nondiabetic patients
    Nikolaus Marx
    Department of Internal Medicine II, Cardiology, University of Ulm, Ulm, Germany
    Circulation 112:2792-8. 2005
    ..In a randomized, placebo-controlled, double-blind trial, we examined the effect of 6-month pioglitazone therapy on neointima volume after coronary stenting in nondiabetic coronary artery disease patients...
  74. ncbi request reprint Refinement of the association of serum C-reactive protein concentration and coronary heart disease risk by correction for within-subject variation over time: the MONICA Augsburg studies, 1984 and 1987
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Robert Koch Strasse 8, D 89081 Ulm, Germany
    Am J Epidemiol 158:357-64. 2003
    ..The results suggest that the true association between C-reactive protein and cardiovascular risk is underestimated by a single C-reactive protein determination, and that several serial C-reactive protein measurements should be taken...
  75. ncbi request reprint Plasminogen levels and risk of coronary artery disease
    Albrecht Hoffmeister
    Department of Internal Medicine II Cardiology, University of Ulm, Robert Koch Strasse 8, D 89081 Ulm, Germany
    Am J Cardiol 90:1168-70. 2002
  76. ncbi request reprint Prevalence of non-alcoholic fatty liver and characteristics in overweight adolescents in the general population
    Armin Imhof
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Germany
    Eur J Epidemiol 22:889-97. 2007
    ....
  77. doi request reprint Association of apolipoproteins with symptoms of asthma and atopy among schoolchildren
    Gabriele Nagel
    Institute of Epidemiology, Ulm University, Ulm, Germany
    Int Arch Allergy Immunol 149:259-66. 2009
    ..We explored the associations between serum apolipoprotein concentrations and symptoms of asthma and atopy...
  78. ncbi request reprint Determination of C-reactive protein: comparison of three high-sensitivity immunoassays
    Natalie Khuseyinova
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Robert Koch Strasse 8, D 89081 Ulm, Germany
    Clin Chem 49:1691-5. 2003
  79. ncbi request reprint Markers of inflammation in women on different hormone replacement therapies
    Margit Fröhlich
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Ann Med 35:353-61. 2003
    ..To measure inflammatory markers in postmenopausal women on different forms of hormone replacement therapy (HRT)...
  80. doi request reprint Copeptin does not add diagnostic information to high-sensitivity troponin T in low- to intermediate-risk patients with acute chest pain: results from the rule out myocardial infarction by computed tomography (ROMICAT) study
    Mahir Karakas
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Clin Chem 57:1137-45. 2011
    ....
  81. ncbi request reprint CD14 C(-260)-->T polymorphism, plasma levels of the soluble endotoxin receptor CD14, their association with chronic infections and risk of stable coronary artery disease
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    J Am Coll Cardiol 40:34-42. 2002
    ..We sought to investigate the association of CD14 genotype and plasma levels of soluble (s)CD14 with risk of stable coronary artery disease (CAD), chronic infections and sensitive markers of systemic inflammation...
  82. ncbi request reprint Biomarkers of outcome from cardiovascular disease
    Natalie Khuseyinova
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Curr Opin Crit Care 12:412-9. 2006
    ..We highlight recent epidemiological and experimental evidence concerning four emerging biomarkers: C-reactive protein, interleukin-6, D-dimer and white blood cell count...
  83. doi request reprint Drinking modulates monocyte migration in healthy subjects: a randomised intervention study of water, ethanol, red wine and beer with or without alcohol
    Armin Imhof
    Department of Internal Medicine II, Cardiology, University of Ulm, Ulm, Medical Centre, Robert Koch Strasse 8, D 89081 Ulm, Germany
    Diab Vasc Dis Res 5:48-53. 2008
    ..Short-term intervention with moderate amounts of ethanol and de-alcoholised red wine inhibits monocyte migration ex vivo. This might represent one mechanism by which alcoholic beverages lower cardiovascular risk...
  84. ncbi request reprint Plasma concentrations of cystatin C in patients with coronary heart disease and risk for secondary cardiovascular events: more than simply a marker of glomerular filtration rate
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Clin Chem 51:321-7. 2005
    ..We evaluated the impact of cystatin C and other markers of RI on prognosis in a large cohort of patients with coronary heart disease (CHD)...
  85. doi request reprint CRP in cardiovascular disease
    Mahir Karakas
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Herz 34:607-13. 2009
    ..JUPITER has revitalized the discussion on CRP in clinical practice and will make it more difficult in the future to neglect the evidence built around CRP and cardiovascular risk...
  86. ncbi request reprint Periodontal infections and coronary heart disease: role of periodontal bacteria and importance of total pathogen burden in the Coronary Event and Periodontal Disease (CORODONT) study
    Axel Spahr
    Department of Operative Dentistry and Periodontology, University of Ulm Medical Center, Ulm, Germany
    Arch Intern Med 166:554-9. 2006
    ..Periodontitis is a possible trigger of chronic inflammation. We investigated the possible association between periodontitis and coronary heart disease (CHD), focusing on microbiological aspects...
  87. ncbi request reprint Predicting risk and treatment benefit in atherosclerosis: the role of C-reactive protein
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Robert Koch Strasse 8, D 89081 Ulm, Germany
    Int J Cardiol 98:199-206. 2005
    ....
  88. doi request reprint Effect of blood glucose concentrations on admission in non-diabetic versus diabetic patients with first acute myocardial infarction on short- and long-term mortality (from the MONICA/KORA Augsburg Myocardial Infarction Registry)
    Judith A Beck
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Am J Cardiol 104:1607-12. 2009
    ..These patients constitute a high-risk group needing aggressive, comprehensive polypharmacotherapy...
  89. ncbi request reprint Acute-phase reactants and coronary heart disease
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Semin Vasc Med 2:417-28. 2002
    ..However, further studies are required to address these associations because the mechanisms that cause an inflammatory response are only incompletely understood and deserve further investigation...
  90. ncbi request reprint Alcohol inflammation and coronary heart disease
    Armin Imhof
    Department of Internal Medicine II Cardiology, University of Ulm Medical Centre, Ulm, Germany
    Addict Biol 8:271-7. 2003
    ....
  91. doi request reprint Angiographic results of a Tacrolimus-eluting stent in acute coronary syndrome lesions
    Angelika Rinker
    Department of Internal Medicine II, University of Ulm, Albert Einstein Allee 23, 89081 Ulm, Germany
    Clin Res Cardiol 98:89-93. 2009
    ....
  92. ncbi request reprint Predicting the risk of cardiovascular disease: where does lipoprotein-associated phospholipase A(2) fit in?
    Natalie Khuseyinova
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Mol Diagn Ther 11:203-17. 2007
    ....
  93. ncbi request reprint Apolipoprotein A-I and risk for cardiovascular diseases
    Natalie Khuseyinova
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Robert Koch Strasse 8, D 89081 Ulm, Germany
    Curr Atheroscler Rep 8:365-73. 2006
    ..This review summarizes our current knowledge based on observations from recent studies, with emphasis on potential pathophysiologic mechanisms of action and on the clinical utility of apoA-I as a predictor of cardiovascular risk...
  94. ncbi request reprint Pregnancy is not a risk factor for gallstone disease: results of a randomly selected population sample
    Thomas Walcher
    University Hospital Ulm, Department of Internal Medicine I, Robert Koch Str 8, D 89081 Ulm, Germany
    World J Gastroenterol 11:6800-6. 2005
    ..To investigate the prevalence, risk factors, and selection of the study population for cholecystolithiasis in an urban population in Germany, in relation to our own findings and to the results in the international literature...
  95. ncbi request reprint Lack of seasonal variation in C-reactive protein
    Margit Fröhlich
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, D 89081 Ulm, Germany
    Clin Chem 48:575-7. 2002
  96. ncbi request reprint Varespladib methyl, an oral phospholipase A2 inhibitor for the potential treatment of coronary artery disease
    Mahir Karakas
    University of Ulm Medical Center, Department of Internal Medicine II Cardiology, Albert Einstein Allee 23, D 89081 Ulm, Germany
    IDrugs 12:585-92. 2009
    ....
  97. ncbi request reprint Fibrin(ogen) in cardiovascular disease: an update
    Wolfgang Koenig
    Dept of Internal Medicine II Cardiology, University of Ulm Medical Center, Robert Koch Str 8, D 89081 Ulm Germany
    Thromb Haemost 89:601-9. 2003
    ....
  98. doi request reprint Myeloperoxidase production by macrophage and risk of atherosclerosis
    Mahir Karakas
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Germany
    Curr Atheroscler Rep 14:277-83. 2012
    ....
  99. ncbi request reprint A case of sudden cardiac death due to isolated eosinophilic coronary arteritis
    Philipp M Lepper
    Department of Internal Medicine II, University of Ulm, Robert Koch Str 8, 89081 Ulm, Germany
    Chest 128:1047-50. 2005
    ..To the best of our knowledge, this is the first case of spontaneous coronary dissection involving all coronary arteries without a history of Churg-Strauss syndrome or hypereosinophilic syndrome...
  100. ncbi request reprint PPAR activators as antiinflammatory mediators in human T lymphocytes: implications for atherosclerosis and transplantation-associated arteriosclerosis
    Nikolaus Marx
    Department of Internal Medicine II, University of Ulm, Ulm, Germany
    Circ Res 90:703-10. 2002
    ....
  101. ncbi request reprint Influence of depressive mood on the association of CRP and obesity in 3205 middle aged healthy men
    Karl Heinz Ladwig
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Ingolstadter Landstr 1, Neuherberg 85764, Germany
    Brain Behav Immun 17:268-75. 2003
    ..These findings suggest a possible synergistic effect of obesity and depressive mood on chronic low level inflammation which may play a crucial role in the pathogenesis of atherosclerosis...