W Koenig

Summary

Affiliation: University of Ulm
Country: Germany

Publications

  1. pmc Prognostic value of interleukin-1 receptor antagonist gene polymorphism and cytomegalovirus seroprevalence in patients with coronary artery disease
    Dietrich Rothenbacher
    Department of Epidemiology, The German Centre for Research on Ageing, University of Heidelberg, Germany
    BMC Cardiovasc Disord 5:10. 2005
  2. ncbi request reprint C-reactive protein: risk assessment in the primary prevention of atherosclerotic disease. Has the time come for including it in the risk profile?
    W Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Germany
    Ital Heart J 2:157-63. 2001
  3. ncbi request reprint C-reactive protein and atherosclerosis: quo vadis?
    W Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Germany
    Ital Heart J 2:801-3. 2001
  4. ncbi request reprint Systemic low-grade inflammation and risk of coronary heart disease: results from the MONICA/KORA Augsburg cohort studies
    W Koenig
    University of Ulm Medical Center, Department of Internal Medicine II Cardiology, Ulm, Germany
    Gesundheitswesen 67:S62-7. 2005
  5. ncbi request reprint Predicting risk and treatment benefit in atherosclerosis: the role of C-reactive protein
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Robert Koch Strasse 8, D 89081 Ulm, Germany
    Int J Cardiol 98:199-206. 2005
  6. ncbi request reprint Fibrin(ogen) in cardiovascular disease: an update
    Wolfgang Koenig
    Dept of Internal Medicine II Cardiology, University of Ulm Medical Center, Robert Koch Str 8, D 89081 Ulm Germany
    Thromb Haemost 89:601-9. 2003
  7. ncbi request reprint Plasma concentrations of cystatin C in patients with coronary heart disease and risk for secondary cardiovascular events: more than simply a marker of glomerular filtration rate
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Clin Chem 51:321-7. 2005
  8. ncbi request reprint Lipoprotein-associated phospholipase A2 adds to risk prediction of incident coronary events by C-reactive protein in apparently healthy middle-aged men from the general population: results from the 14-year follow-up of a large cohort from southern Germany
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Robert Koch Strasse 8, D 89081 Ulm, Germany
    Circulation 110:1903-8. 2004
  9. ncbi request reprint Refinement of the association of serum C-reactive protein concentration and coronary heart disease risk by correction for within-subject variation over time: the MONICA Augsburg studies, 1984 and 1987
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Robert Koch Strasse 8, D 89081 Ulm, Germany
    Am J Epidemiol 158:357-64. 2003
  10. ncbi request reprint C-reactive protein modulates risk prediction based on the Framingham Score: implications for future risk assessment: results from a large cohort study in southern Germany
    Wolfgang Koenig
    Department of Internal Medicine II, Cardiology, University of Ulm Medical Center, Robert Koch Str 8, D 89081 Ulm, Germany
    Circulation 109:1349-53. 2004

Collaborators

Detail Information

Publications121 found, 100 shown here

  1. pmc Prognostic value of interleukin-1 receptor antagonist gene polymorphism and cytomegalovirus seroprevalence in patients with coronary artery disease
    Dietrich Rothenbacher
    Department of Epidemiology, The German Centre for Research on Ageing, University of Heidelberg, Germany
    BMC Cardiovasc Disord 5:10. 2005
    ....
  2. ncbi request reprint C-reactive protein: risk assessment in the primary prevention of atherosclerotic disease. Has the time come for including it in the risk profile?
    W Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Germany
    Ital Heart J 2:157-63. 2001
    ..Such an improved prescription strategy might be especially valuable in the primary care setting where the absolute cardiovascular risk is considerably lower compared to that in secondary prevention...
  3. ncbi request reprint C-reactive protein and atherosclerosis: quo vadis?
    W Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Germany
    Ital Heart J 2:801-3. 2001
    ..In this paper we summarize the current evidence for an involvement of CRP in atherogenesis and we speculate about potential therapeutic implications these observations might have...
  4. ncbi request reprint Systemic low-grade inflammation and risk of coronary heart disease: results from the MONICA/KORA Augsburg cohort studies
    W Koenig
    University of Ulm Medical Center, Department of Internal Medicine II Cardiology, Ulm, Germany
    Gesundheitswesen 67:S62-7. 2005
    ..We tested the association of these new biomarkers with traditional risk factors and their ability to predict incident coronary events, using the MONICA/KORA database...
  5. ncbi request reprint Predicting risk and treatment benefit in atherosclerosis: the role of C-reactive protein
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Robert Koch Strasse 8, D 89081 Ulm, Germany
    Int J Cardiol 98:199-206. 2005
    ....
  6. ncbi request reprint Fibrin(ogen) in cardiovascular disease: an update
    Wolfgang Koenig
    Dept of Internal Medicine II Cardiology, University of Ulm Medical Center, Robert Koch Str 8, D 89081 Ulm Germany
    Thromb Haemost 89:601-9. 2003
    ....
  7. ncbi request reprint Plasma concentrations of cystatin C in patients with coronary heart disease and risk for secondary cardiovascular events: more than simply a marker of glomerular filtration rate
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Clin Chem 51:321-7. 2005
    ..We evaluated the impact of cystatin C and other markers of RI on prognosis in a large cohort of patients with coronary heart disease (CHD)...
  8. ncbi request reprint Lipoprotein-associated phospholipase A2 adds to risk prediction of incident coronary events by C-reactive protein in apparently healthy middle-aged men from the general population: results from the 14-year follow-up of a large cohort from southern Germany
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Robert Koch Strasse 8, D 89081 Ulm, Germany
    Circulation 110:1903-8. 2004
    ..Chronic inflammation represents an essential feature of the atherosclerotic process. Lipoprotein-associated phospholipase A2 (Lp-PLA2), an enzyme mainly produced by monocytes/macrophages, generates potent proinflammatory products...
  9. ncbi request reprint Refinement of the association of serum C-reactive protein concentration and coronary heart disease risk by correction for within-subject variation over time: the MONICA Augsburg studies, 1984 and 1987
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Robert Koch Strasse 8, D 89081 Ulm, Germany
    Am J Epidemiol 158:357-64. 2003
    ..The results suggest that the true association between C-reactive protein and cardiovascular risk is underestimated by a single C-reactive protein determination, and that several serial C-reactive protein measurements should be taken...
  10. ncbi request reprint C-reactive protein modulates risk prediction based on the Framingham Score: implications for future risk assessment: results from a large cohort study in southern Germany
    Wolfgang Koenig
    Department of Internal Medicine II, Cardiology, University of Ulm Medical Center, Robert Koch Str 8, D 89081 Ulm, Germany
    Circulation 109:1349-53. 2004
    ..We sought to assess the potential of CRP measurements to enhance risk prediction based on the Framingham Risk Score (FRS) in a large cohort of middle-aged men from the general population...
  11. ncbi request reprint Lipoprotein-associated phospholipase A2 predicts future cardiovascular events in patients with coronary heart disease independently of traditional risk factors, markers of inflammation, renal function, and hemodynamic stress
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Robert Koch Str 8, D 89081 Ulm, Germany
    Arterioscler Thromb Vasc Biol 26:1586-93. 2006
    ..We sought to evaluate whether lipoprotein-associated phospholipase A2 (Lp-PLA2), an emerging marker of cardiovascular risk, is associated with prognosis in patients with coronary heart disease (CHD)...
  12. ncbi request reprint Plasma viscosity and the risk of coronary heart disease: results from the MONICA-Augsburg Cohort Study, 1984 to 1992
    W Koenig
    Department of Internal Medicine II, Cardiology, University of Ulm Medical Center, Germany
    Arterioscler Thromb Vasc Biol 18:768-72. 1998
    ..A large proportion of events (40%) occurred among men in the highest quintile. These findings suggest that plasma viscosity may have considerable potential to identify subjects at risk for CHD events...
  13. ncbi request reprint Association between plasma viscosity and all-cause mortality: results from the MONICA-Augsburg Cohort Study 1984-92
    W Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Centre, Ulm, Germany
    Br J Haematol 109:453-8. 2000
    ..68 (95% CI 1.63-4.42). These findings suggest that plasma viscosity may have considerable potential to predict death from all causes in middle-aged men...
  14. ncbi request reprint Exercise and thrombosis
    W Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Centre, Germany
    Coron Artery Dis 11:123-7. 2000
    ..It is concluded that physical activity has profound effects on thrombogenic factors and that these mechanisms could contribute to its beneficial cardiovascular effects...
  15. ncbi request reprint Infection with Helicobacter pylori is not a major independent risk factor for stable coronary heart disease: lack of a role of cytotoxin-associated protein A-positive strains and absence of a systemic inflammatory response
    W Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Circulation 100:2326-31. 1999
    ....
  16. ncbi request reprint C-Reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men: results from the MONICA (Monitoring Trends and Determinants in Cardiovascular Disease) Augsburg Cohort Study, 1984
    W Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Circulation 99:237-42. 1999
    ..Recent studies indicate that systemic markers of inflammation can identify subjects at high risk of coronary events...
  17. ncbi request reprint Chronic infection with Helicobacter pylori does not provoke major systemic inflammation in healthy adults: results from a large population-based study
    H Brenner
    Department of Epidemiology, University of Ulm, Helmholtzstrasse 22, D 89081, Ulm, Germany
    Atherosclerosis 147:399-403. 1999
    ..pylori strains provokes major systemic inflammation. The mechanisms underlying the inverse association between H. pylori infection and serum albumin and the clinical relevance of this finding require further research...
  18. ncbi request reprint Current infection with Helicobacter pylori, but not seropositivity to Chlamydia pneumoniae or cytomegalovirus, is associated with an atherogenic, modified lipid profile
    A Hoffmeister
    Department of Internal Medicine II-Cardiology, University of Ulm, Ulm, Germany
    Arterioscler Thromb Vasc Biol 21:427-32. 2001
    ..These lipid alterations could explain, at least in part, the reported weak association between chronic HP infection and atherosclerotic diseases...
  19. ncbi request reprint Seasonal variations of rheological and hemostatic parameters and acute-phase reactants in young, healthy subjects
    M Frohlich
    Department of Internal Medicine II, Cardiology, University of Ulm Medical Center, Germany
    Arterioscler Thromb Vasc Biol 17:2692-7. 1997
    ..The cause for the seasonal variations in rheological and hemostatic parameters remains unclear and should be studied in more detail...
  20. ncbi request reprint Seropositivity to chlamydial lipopolysaccharide and Chlamydia pneumoniae, systemic inflammation and stable coronary artery disease: negative results of a case-control study
    A Hoffmeister
    Department of Internal Medicine II Cardiology, University of Ulm, Germany
    J Am Coll Cardiol 35:112-8. 2000
    ....
  21. ncbi request reprint Aspirin (5 mmol/L) inhibits leukocyte attack and triggered reactive cell proliferation in a 3D human coronary in vitro model
    R Voisard
    Department of Internal Medicine II, Division of Cardiology, University of Ulm, Germany
    Circulation 103:1688-94. 2001
    ..In the present study, we used a 3D human coronary in vitro model of LA (3DLA model) to examine the effect of high-dose aspirin on the adhesion and chemotaxis of leukocytes and the reactive proliferative response of SMCs...
  22. ncbi request reprint Association between C-reactive protein and features of the metabolic syndrome: a population-based study
    M Frohlich
    Department of Internal Medicine II, University of Ulm Medical Center, Germany
    Diabetes Care 23:1835-9. 2000
    ..To assess the association of circulating levels of C-reactive protein, a sensitive systemic marker of inflammation, with different components of the metabolic syndrome...
  23. ncbi request reprint Alcohol inflammation and coronary heart disease
    Armin Imhof
    Department of Internal Medicine II Cardiology, University of Ulm Medical Centre, Ulm, Germany
    Addict Biol 8:271-7. 2003
    ....
  24. ncbi request reprint Exercise and thrombosis
    A Imhof
    Department of Internal Medicine II-Cardiology, University of Ulm Medical Centre, Ulm, Germany
    Cardiol Clin 19:389-400. 2001
    ..Patients with ischemic heart disease, who cannot increase their fibrinolytic potential, however, may be at considerable risk for acute ischemic events if they are exposed to unaccustomed strenuous physical exertion...
  25. ncbi request reprint Plasma fibrin D-dimer levels and risk of stable coronary artery disease: results of a large case-control study
    W Koenig
    Department of Internal Medicine II-Cardiology, University of Ulm Medical Center, University of Ulm, Ulm, Sweden
    Arterioscler Thromb Vasc Biol 21:1701-5. 2001
    ..9). Plasma D-dimer levels are strongly and independently associated with the presence of CAD in patients with stable angina pectoris. These results support the concept of a contribution of intravascular fibrin to atherothrombogenesis...
  26. ncbi request reprint Overall alcohol intake, beer, wine, and systemic markers of inflammation in western Europe: results from three MONICA samples (Augsburg, Glasgow, Lille)
    A Imhof
    Dept of Internal Medicine II, Cardiology, University of Ulm Medical Center, Robert Koch Strasse 8, D 89081 Ulm, Germany
    Eur Heart J 25:2092-100. 2004
    ..We investigated the relationship between overall alcohol, beer or wine consumption and markers of systemic inflammation in three different geographical areas in Europe...
  27. doi request reprint The effect of alcohol, tobacco and caffeine consumption and vegetarian diet on gallstone prevalence
    Thomas Walcher
    Department of Internal Medicine II, University Hospital Ulm, Germany
    Eur J Gastroenterol Hepatol 22:1345-51. 2010
    ..To investigate the effects of alcohol, tobacco and caffeine consumption and of vegetarian diet on gallstone prevalence in an urban population sample...
  28. ncbi request reprint Effect of alcohol consumption on systemic markers of inflammation
    A Imhof
    Department of Internal Medicine II-Cardiology, University of Ulm Medical Centre, Germany
    Lancet 357:763-7. 2001
    ....
  29. ncbi request reprint PPAR activators as antiinflammatory mediators in human T lymphocytes: implications for atherosclerosis and transplantation-associated arteriosclerosis
    Nikolaus Marx
    Department of Internal Medicine II, University of Ulm, Ulm, Germany
    Circ Res 90:703-10. 2002
    ....
  30. ncbi request reprint Increased concentrations of C-reactive protein and IL-6 but not IL-18 are independently associated with incident coronary events in middle-aged men and women: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Arterioscler Thromb Vasc Biol 26:2745-51. 2006
    ....
  31. doi request reprint Myeloperoxidase is associated with incident coronary heart disease independently of traditional risk factors: results from the MONICA/KORA Augsburg study
    M Karakas
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    J Intern Med 271:43-50. 2012
    ..Myeloperoxidase (MPO) is a marker of oxidative stress. We prospectively investigated whether an increased serum concentration of MPO is associated with an increased risk of incident coronary heart disease (CHD)...
  32. ncbi request reprint Role of novel markers of inflammation in patients with stable coronary heart disease
    A Hoffmeister
    Department of Internal Medicine II Cardiology, University of Ulm, Germany
    Am J Cardiol 87:262-6. 2001
    ..The combination of several of these biochemical markers, i.e., the determination of an "inflammatory risk profile," may be useful to further stratify cardiovascular risk...
  33. pmc Vitamin C supplement use may protect against gallstones: an observational study on a randomly selected population
    Thomas Walcher
    Department of Internal Medicine I, University Hospital Ulm, Ulm, Germany
    BMC Gastroenterol 9:74. 2009
    ..The aim of this study was to assess the possible association of regular vitamin C supplementation with gallstone prevalence...
  34. ncbi request reprint Prospective study of high-sensitivity C-reactive protein as a determinant of mortality: results from the MONICA/KORA Augsburg Cohort Study, 1984-1998
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Clin Chem 54:335-42. 2008
    ..Because other chronic diseases are also associated with an inflammatory response, we sought to assess the association of high-sensitivity CRP (hsCRP) with total and cause-specific mortality in a large cohort of middle-aged men...
  35. ncbi request reprint Rapid effects of rosiglitazone treatment on endothelial function and inflammatory biomarkers
    Jurgen Hetzel
    Department of Internal Medicine II Cardiology, University of Ulm, Ulm, Germany
    Arterioscler Thromb Vasc Biol 25:1804-9. 2005
    ..Therefore, the present study examined whether short-term rosiglitazone treatment influences endothelium-dependent vasodilation as well as serum levels of vascular disease biomarkers in healthy, nondiabetic subjects...
  36. ncbi request reprint C-reactive protein and atherosclerosis. Is there a causal link?
    D E Manolov
    Department of Internal Medicine II Cardiology, University of Ulm, Ulm, Germany
    Histol Histopathol 18:1189-93. 2003
    ..Should CRP indeed be actively involved in human atherogenesis, the molecule may become a target for therapy. Pharmaceutical companies develop CRP-inhibitors...
  37. ncbi request reprint [Effect of molsidomine on rheological parameters and the incidence of cardiovascular events]
    J Wohrle
    Abteilung Innere Medizin II, Universitat Ulm
    Dtsch Med Wochenschr 128:1333-7. 2003
    ..We studied the effect of highly-dosed NO-donor molsidomine on blood rheology and the impact of rheological parameters on the incidence of severe cardiovascular events...
  38. doi request reprint Long term effects of comprehensive cardiac rehabilitation in an inpatient and outpatient setting
    Juergen M Steinacker
    Section of Sports and Rehabilitation Medicine, University of Ulm, Steinhövelweg 9, 89070 Ulm, Germany
    Swiss Med Wkly 140:w13141. 2011
    ..To compare the long-term effects of comprehensive outpatient versus inpatient rehabilitation with respect to morbidity and mortality, as well as to changes in physical performance and physical activity...
  39. doi request reprint CRP in cardiovascular disease
    Mahir Karakas
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Herz 34:607-13. 2009
    ..JUPITER has revitalized the discussion on CRP in clinical practice and will make it more difficult in the future to neglect the evidence built around CRP and cardiovascular risk...
  40. doi request reprint Drinking modulates monocyte migration in healthy subjects: a randomised intervention study of water, ethanol, red wine and beer with or without alcohol
    Armin Imhof
    Department of Internal Medicine II, Cardiology, University of Ulm, Ulm, Medical Centre, Robert Koch Strasse 8, D 89081 Ulm, Germany
    Diab Vasc Dis Res 5:48-53. 2008
    ..Short-term intervention with moderate amounts of ethanol and de-alcoholised red wine inhibits monocyte migration ex vivo. This might represent one mechanism by which alcoholic beverages lower cardiovascular risk...
  41. doi request reprint Association of apolipoproteins with symptoms of asthma and atopy among schoolchildren
    Gabriele Nagel
    Institute of Epidemiology, Ulm University, Ulm, Germany
    Int Arch Allergy Immunol 149:259-66. 2009
    ..We explored the associations between serum apolipoprotein concentrations and symptoms of asthma and atopy...
  42. ncbi request reprint Biomarkers of outcome from cardiovascular disease
    Natalie Khuseyinova
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Curr Opin Crit Care 12:412-9. 2006
    ..We highlight recent epidemiological and experimental evidence concerning four emerging biomarkers: C-reactive protein, interleukin-6, D-dimer and white blood cell count...
  43. ncbi request reprint A case of sudden cardiac death due to isolated eosinophilic coronary arteritis
    Philipp M Lepper
    Department of Internal Medicine II, University of Ulm, Robert Koch Str 8, 89081 Ulm, Germany
    Chest 128:1047-50. 2005
    ..To the best of our knowledge, this is the first case of spontaneous coronary dissection involving all coronary arteries without a history of Churg-Strauss syndrome or hypereosinophilic syndrome...
  44. ncbi request reprint Prevalence of the metabolic syndrome in southwest Germany
    Bernhard O Boehm
    Dept Internal Medicine I, Univ Hospital Ulm, Univ of Ulm, Germany
    Scand J Clin Lab Invest Suppl 240:122-8. 2005
    ..The urgent need for preventive measures aimed at reducing the significantly increased health risk is underscored...
  45. doi request reprint Associations of adipokines with asthma, rhinoconjunctivitis, and eczema in German schoolchildren
    Gabriele Nagel
    Institute of Epidemiology, Ulm University, Ulm, Germany
    Pediatr Allergy Immunol 20:81-8. 2009
    ..These results suggest that adipokines may contribute to increased asthma and allergy risk in obese subjects. Stronger associations among girls with non-atopic asthma may indicate diverse pathological mechanisms...
  46. ncbi request reprint Prevalence and cluster of cardiometabolic biomarkers in overweight and obese schoolchildren: results from a large survey in southwest Germany
    Gabriele Nagel
    Institute of Epidemiology, Ulm University, Ulm, Germany
    Clin Chem 54:317-25. 2008
    ..Obesity is associated with substantial metabolic changes and subclinical inflammation. We explored associations between body mass index (BMI) and cardiometabolic biomarkers and their clustering in overweight and obese schoolchildren...
  47. ncbi request reprint Acute-phase reactants and coronary heart disease
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Semin Vasc Med 2:417-28. 2002
    ..However, further studies are required to address these associations because the mechanisms that cause an inflammatory response are only incompletely understood and deserve further investigation...
  48. pmc Effect of drinking on adiponectin in healthy men and women: a randomized intervention study of water, ethanol, red wine, and beer with or without alcohol
    Armin Imhof
    Department of Internal Medicine II, Cardiology, University of Ulm, Ulm, Germany
    Diabetes Care 32:1101-3. 2009
    ..Moderate alcohol consumption is associated with reduced incidence of type 2 diabetes and cardiovascular mortality and increases adiponectin concentrations, but effects might differ according to sex and beverage consumed...
  49. ncbi request reprint Pioglitazone reduces neointima volume after coronary stent implantation: a randomized, placebo-controlled, double-blind trial in nondiabetic patients
    Nikolaus Marx
    Department of Internal Medicine II, Cardiology, University of Ulm, Ulm, Germany
    Circulation 112:2792-8. 2005
    ..In a randomized, placebo-controlled, double-blind trial, we examined the effect of 6-month pioglitazone therapy on neointima volume after coronary stenting in nondiabetic coronary artery disease patients...
  50. doi request reprint Leptin, adiponectin, their ratio and risk of Coronary Heart Disease: results from the MONICA/KORA Augsburg Study 1984-2002
    Mahir Karakas
    University of Ulm Medical Center, Department of Internal Medicine II Cardiology, Albert Einstein Allee 23, Ulm, Germany
    Atherosclerosis 209:220-5. 2010
    ....
  51. ncbi request reprint Environmental tobacco smoke and cardiometabolic risk in young children: results from a survey in south-west Germany
    Gabriele Nagel
    Institute of Epidemiology, Ulm University, 89081 Ulm, Germany
    Eur Heart J 30:1885-93. 2009
    ..We explored the association between exposure to environmental tobacco smoke (ETS) and various cardiometabolic biomarkers in 10-year-old children...
  52. ncbi request reprint Prevalence of non-alcoholic fatty liver and characteristics in overweight adolescents in the general population
    Armin Imhof
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Germany
    Eur J Epidemiol 22:889-97. 2007
    ....
  53. doi request reprint Reproducibility in serial C-reactive protein and interleukin-6 measurements in post-myocardial infarction patients: results from the AIRGENE study
    Mahir Karakas
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Clin Chem 56:861-4. 2010
    ..Implementation of hsCRP and IL-6 measurement into clinical practice requires data on the reliability of such measurements...
  54. ncbi request reprint Independent association of various smoking characteristics with markers of systemic inflammation in men. Results from a representative sample of the general population (MONICA Augsburg Survey 1994/95)
    Margit Fröhlich
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Eur Heart J 24:1365-72. 2003
    ..Aim of the study was to investigate the association between various markers of systemic inflammation and a detailed history of smoking in a large representative sample of the general population...
  55. ncbi request reprint Antidiabetic PPAR gamma-activator rosiglitazone reduces MMP-9 serum levels in type 2 diabetic patients with coronary artery disease
    Nikolaus Marx
    Department of Internal Medicine II Cardiology, University of Ulm, Germany
    Arterioscler Thromb Vasc Biol 23:283-8. 2003
    ....
  56. ncbi request reprint Effect of rosiglitazone treatment on soluble CD40L in patients with type 2 diabetes and coronary artery disease
    Nikolaus Marx
    Department of Internal Medicine II Cardiology, University of Freiburg, Germany
    Circulation 107:1954-7. 2003
    ....
  57. ncbi request reprint Direct enzyme immunometric measurement of plasma big endothelin-I concentrations and correlation with indicators of left ventricular function
    C Haug
    Institute of Clinical Chemistry, University Hospital, Ulm, Germany
    Clin Chem 44:239-43. 1998
    ..These data suggest that plasma big endothelin-1 concentrations, measured by a direct ELISA, correlate with hemodynamic indicators and symptoms of left ventricular dysfunction...
  58. doi request reprint Effect of blood glucose concentrations on admission in non-diabetic versus diabetic patients with first acute myocardial infarction on short- and long-term mortality (from the MONICA/KORA Augsburg Myocardial Infarction Registry)
    Judith A Beck
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Am J Cardiol 104:1607-12. 2009
    ..These patients constitute a high-risk group needing aggressive, comprehensive polypharmacotherapy...
  59. doi request reprint Lipoprotein-associated and secretory phospholipase A2 in cardiovascular disease: the epidemiological evidence
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Albert Einstein Allee, 23, 89081, Ulm, Germany
    Cardiovasc Drugs Ther 23:85-92. 2009
    ..Moreover, Lp-PLA(2) might have similar predictive power for both, incident CHD in initially healthy subjects, as well as for recurrent events in those with clinically manifest atherosclerosis...
  60. ncbi request reprint Association study between variants in the fibrinogen gene cluster, fibrinogen levels and hypertension: results from the MONICA/KORA study
    Melanie Kolz
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Robert Koch Str 8, D 89081 Ulm, Germany
    Thromb Haemost 101:317-24. 2009
    ..In addition, one FGA promoter variant was significantly associated with hypertension in women. Confirmation of these findings by future studies is warranted...
  61. ncbi request reprint Lack of seasonal variation in C-reactive protein
    Margit Fröhlich
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, D 89081 Ulm, Germany
    Clin Chem 48:575-7. 2002
  62. ncbi request reprint Plasma lipoprotein Lp(a), markers of haemostasis and inflammation, and risk and severity of coronary heart disease
    Armin Imhof
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Eur J Cardiovasc Prev Rehabil 10:362-70. 2003
    ..Little is known about potential atherothrombogenic mechanisms of Lp(a)...
  63. doi request reprint Rapid effect of single-dose rosiglitazone treatment on endothelial function in healthy men with normal glucose tolerance: data from a randomised, placebo-controlled, double-blind study
    Thomas Walcher
    Department of Internal Medicine II Cardiology, University of Ulm, Germany
    Diab Vasc Dis Res 7:178-85. 2010
    ....
  64. ncbi request reprint CD14 C(-260)-->T polymorphism, plasma levels of the soluble endotoxin receptor CD14, their association with chronic infections and risk of stable coronary artery disease
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    J Am Coll Cardiol 40:34-42. 2002
    ..We sought to investigate the association of CD14 genotype and plasma levels of soluble (s)CD14 with risk of stable coronary artery disease (CAD), chronic infections and sensitive markers of systemic inflammation...
  65. ncbi request reprint Variability of serial lipoprotein-associated phospholipase A2 measurements in post myocardial infarction patients: results from the AIRGENE Study Center Augsburg
    Natalie Khuseyinova
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Clin Chem 54:124-30. 2008
    ..Implementation of Lp-PLA(2) measurement into clinical practice, however, requires data on the reliability of such measurements...
  66. ncbi request reprint Serum concentrations of adiponectin and risk of type 2 diabetes mellitus and coronary heart disease in apparently healthy middle-aged men: results from the 18-year follow-up of a large cohort from southern Germany
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    J Am Coll Cardiol 48:1369-77. 2006
    ....
  67. ncbi request reprint Association between Lp-PLA2 and coronary artery disease: focus on its relationship with lipoproteins and markers of inflammation and hemostasis
    Natalie Khuseyinova
    Department of Internal Medicine II, Cardiology, University of Ulm Medical Center, Robert Koch Str 8, D 89081 Ulm, Germany
    Atherosclerosis 182:181-8. 2005
    ..12-3.28). Thus, elevated Lp-PLA2 concentrations were associated with the presence of stable CAD, independent of various biochemical markers. Our results support the hypothesis that Lp-PLA2 may be a novel, independent risk marker for CAD...
  68. ncbi request reprint Associations of fatty liver disease and other factors affecting serum SHBG concentrations: a population based study on 1657 subjects
    M Flechtner-Mors
    Institute of Epidemiology and Medical Biometry, Ulm, Germany
    Horm Metab Res 46:287-93. 2014
    ..Age, BMI and waist-to-hip ratio also influence the SHBG concentration. Based on these findings, we conclude that fat accumulation in the liver influences SHBG concentrations in men and premenopausal women. ..
  69. doi request reprint Variability of fibrinogen measurements in post-myocardial infarction patients. Results from the AIRGENE study center Augsburg
    Jens Baumert
    Institute of Epidemiology II, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Thromb Haemost 107:895-902. 2012
    ..The present study indicates a fairly good reproducibility of serial individual fibrinogen measurements in post-MI subjects...
  70. ncbi request reprint Periodontal infections and coronary heart disease: role of periodontal bacteria and importance of total pathogen burden in the Coronary Event and Periodontal Disease (CORODONT) study
    Axel Spahr
    Department of Operative Dentistry and Periodontology, University of Ulm Medical Center, Ulm, Germany
    Arch Intern Med 166:554-9. 2006
    ..Periodontitis is a possible trigger of chronic inflammation. We investigated the possible association between periodontitis and coronary heart disease (CHD), focusing on microbiological aspects...
  71. ncbi request reprint Markers of inflammation in women on different hormone replacement therapies
    Margit Fröhlich
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Ann Med 35:353-61. 2003
    ..To measure inflammatory markers in postmenopausal women on different forms of hormone replacement therapy (HRT)...
  72. doi request reprint Association between type II secretory phospholipase A2 plasma concentrations and activity and cardiovascular events in patients with coronary heart disease
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Albert Einstein Allee 23, Ulm, Germany
    Eur Heart J 30:2742-8. 2009
    ..We sought to evaluate whether systemic sPLA(2) is associated with prognosis in patients with coronary heart disease (CHD)...
  73. doi request reprint Update on integrated biomarkers for assessment of long-term risk of cardiovascular complications in initially healthy subjects and patients with manifest atherosclerosis
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Albert Einstein Allee 23, Ulm, Germany
    Ann Med 41:332-43. 2009
    ....
  74. pmc Genetic variation in Fc gamma receptor IIa and risk of coronary heart disease: negative results from two large independent populations
    Mahir Karakas
    Department of Internal Medicine II Cardiology, University of Ulm, Germany
    BMC Med Genet 10:46. 2009
    ..We sought to investigate the association of Fc gamma RIIa genotype with risk of coronary heart disease (CHD) in two large population-based samples...
  75. ncbi request reprint Predicting the risk of cardiovascular disease: where does lipoprotein-associated phospholipase A(2) fit in?
    Natalie Khuseyinova
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Mol Diagn Ther 11:203-17. 2007
    ....
  76. doi request reprint Prospective evaluation of renal function, serum vitamin D level, and risk of fall and fracture in community-dwelling elderly subjects
    D Rothenbacher
    Institute of Epidemiology and Medical Biometry, Ulm University, Helmholtzstr 22, 89081, Ulm, Germany
    Osteoporos Int 25:923-32. 2014
    ..However, 25-hydroxyvitamin D levels were clearly inversely associated with risk for first fall, which was especially seen in subjects with calcium levels above median...
  77. ncbi request reprint Inflammation and coronary heart disease: an overview
    W Koenig
    FESC, FACC, Department of Internal Medicine II-Cardiology, University of Ulm Medical Center, Robert-Koch-Strasse 8, D-89081 Ulm, Germany
    Cardiol Rev 9:31-5. 2001
    ..This article discusses the pathogenesis of atherosclerosis, the role of endothelial dysfunction and plaque rupture, and evidence for the role of inflammation and reviews how therapy might reduce vascular inflammation...
  78. ncbi request reprint Leukocyte attack in a 3D human coronary in-vitro model
    R Voisard
    Department of Internal Medicine II Cardiology, University of Ulm, Germany
    Coron Artery Dis 12:401-11. 2001
    ..Three-dimensional human coronary in-vitro units of leukocyte attack (3DLA-units) open the field for exact studies of leukocyte attack and its subsequent effects on human medial coronary smooth muscle cells (HCMSMC)...
  79. pmc Accelerometer-based physical activity in a large observational cohort--study protocol and design of the activity and function of the elderly in Ulm (ActiFE Ulm) study
    Michael D Denkinger
    Agaplesion Bethesda Clinic, Ulm, Germany
    BMC Geriatr 10:50. 2010
    ....
  80. ncbi request reprint Integrating biomarkers: the new frontier?
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Scand J Clin Lab Invest Suppl 242:117-23. 2010
    ..Thus, more data, preferably from serial measurements in large populations taking also into account new candidates from "omics" technology are needed to gain further insight in the potential clinical usefulness of an integrated approach...
  81. doi request reprint Impact of pioglitazone on coronary endothelial function in non-diabetic patients with coronary artery disease
    Jochen Wohrle
    Department of Internal Medicine II, University of Ulm, Ulm, Germany
    Clin Res Cardiol 97:726-33. 2008
    ..We studied the hypothesis that pioglitazone improves coronary endothelial dysfunction in non-diabetic patients with coronary artery disease (CAD) in a randomized, placebo-controlled, double-blind trial...
  82. doi request reprint Association between degenerative aortic valve disease and long-term exposure to cardiovascular risk factors: results of the longitudinal population-based KORA/MONICA survey
    Jan Stritzke
    Department of Internal Medicine II, University of Lubeck, Lubeck, Germany
    Eur Heart J 30:2044-53. 2009
    ..Taking advantage of its longitudinal design, this study evaluates the prevalence of DAVD and its temporal associations with long-term exposure to cardiovascular risk factors in the general population...
  83. ncbi request reprint Apolipoprotein A-I and risk for cardiovascular diseases
    Natalie Khuseyinova
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Robert Koch Strasse 8, D 89081 Ulm, Germany
    Curr Atheroscler Rep 8:365-73. 2006
    ..This review summarizes our current knowledge based on observations from recent studies, with emphasis on potential pathophysiologic mechanisms of action and on the clinical utility of apoA-I as a predictor of cardiovascular risk...
  84. ncbi request reprint Biomarkers of atherosclerotic plaque instability and rupture
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Robert Koch Str 8, D 89081 Ulm, Germany
    Arterioscler Thromb Vasc Biol 27:15-26. 2007
    ..However, for most of these biomarkers the clinical utility has not yet been established...
  85. ncbi request reprint Distributions of C-reactive protein measured by high-sensitivity assays in apparently healthy men and women from different populations in Europe
    Armin Imhof
    Department of Internal Medicine II, Cardiology, University of Ulm, Germany
    Clin Chem 49:669-72. 2003
  86. ncbi request reprint Determination of C-reactive protein: comparison of three high-sensitivity immunoassays
    Natalie Khuseyinova
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Robert Koch Strasse 8, D 89081 Ulm, Germany
    Clin Chem 49:1691-5. 2003
  87. ncbi request reprint Elevated levels of interleukin-18 predict the development of type 2 diabetes: results from the MONICA/KORA Augsburg Study, 1984-2002
    Barbara Thorand
    GF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Diabetes 54:2932-8. 2005
    ..This association is independent of a generalized proinflammatory state, but subjects with elevated levels of several inflammatory markers seem to be particularly prone to develop type 2 diabetes...
  88. ncbi request reprint Plasma oxidized low-density lipoprotein, a strong predictor for acute coronary heart disease events in apparently healthy, middle-aged men from the general population
    Christa Meisinger
    GSF The National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Circulation 112:651-7. 2005
    ..Oxidized LDL (oxLDL) is thought to play a key role in the inflammatory response in the arterial vessel wall...
  89. ncbi request reprint Biomarkers for mortality and cardiovascular events
    Wolfgang Koenig
    JAMA 294:303; author reply 303-4. 2005
  90. ncbi request reprint C-reactive protein, depressed mood, and the prediction of coronary heart disease in initially healthy men: results from the MONICA-KORA Augsburg Cohort Study 1984-1998
    Karl Heinz Ladwig
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Ingolstadter Landstr 1, 85764 Neuherberg, Germany
    Eur Heart J 26:2537-42. 2005
    ..The goal of the present study was to assess possible combined effects of these factors on the prediction of a future fatal and non-fatal coronary event...
  91. ncbi request reprint Sex differences in the relation of body composition to markers of inflammation
    Barbara Thorand
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Atherosclerosis 184:216-24. 2006
    ..It has been suggested that low-grade systemic inflammation is associated with obesity and that this association might be modified by sex...
  92. ncbi request reprint Prognostic value of apolipoprotein B and A-I in the prediction of myocardial infarction in middle-aged men and women: results from the MONICA/KORA Augsburg cohort study
    Christa Meisinger
    Central Hospital of Augsburg, MONICA KORA Myocardial Infarction Registry, Augsburg, Germany
    Eur Heart J 26:271-8. 2005
    ..To investigate the association between apolipoprotein B (apoB), A-I (apoA-I), the apoB/apoA-I ratio, and the incidence of coronary events...
  93. ncbi request reprint CDC/AHA Workshop on Markers of Inflammation and Cardiovascular Disease: Application to Clinical and Public Health Practice: report from the clinical practice discussion group
    Sidney C Smith
    Circulation 110:e550-3. 2004
  94. ncbi request reprint Evaluation of diagnostic relevance of mRNA levels in peripheral blood: predictive value for mortality in hemodialysis patients
    Reiner Füth
    German Diabetes Centre, German Diabetes Research Institute at the Heinrich Heine University Düsseldorf, Auf m Hennekamp 65, 40225 Dusseldorf, Germany
    Cytokine 27:166-72. 2004
    ..This study shows that gene expression patterns of circulating leukocytes may present an important new diagnostic tool to predict clinical outcome in patients with inflammatory vascular diseases...
  95. ncbi request reprint Global suppression of IL-6-induced acute phase response gene expression after chronic in vivo treatment with the peroxisome proliferator-activated receptor-alpha activator fenofibrate
    Philippe Gervois
    Gaubius Laboratory, TNO Prevention and Health, Zernikedreef 9, P O Box 2215, 2301 CE Leiden, The Netherlands
    J Biol Chem 279:16154-60. 2004
    ....
  96. ncbi request reprint Effect of Helicobacter pylori eradication on high-density lipoprotein cholesterol
    Hubert Scharnagl
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, University and General Hospital, University of Graz, Graz, Austria
    Am J Cardiol 93:219-20. 2004
    ..Our results suggest that chronic H. pylori infection reduces plasma levels of HDL cholesterol and that eradication improves the lipoprotein pattern...
  97. ncbi request reprint The endotoxin receptor TLR4 polymorphism is not associated with diabetes or components of the metabolic syndrome
    Thomas Illig
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Diabetes 52:2861-4. 2003
  98. ncbi request reprint From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part II
    Morteza Naghavi
    The Center for Vulnerable Plaque Research, University of Texas Houston, The Texas Heart Institute, and President Bush Center for Cardiovascular Health, Memorial Hermann Hospital, Houston, USA
    Circulation 108:1772-8. 2003
    ..We encourage healthcare policy makers to promote translational research for screening and treatment of vulnerable patients...
  99. ncbi request reprint Influence of depressive mood on the association of CRP and obesity in 3205 middle aged healthy men
    Karl Heinz Ladwig
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Ingolstadter Landstr 1, Neuherberg 85764, Germany
    Brain Behav Immun 17:268-75. 2003
    ..These findings suggest a possible synergistic effect of obesity and depressive mood on chronic low level inflammation which may play a crucial role in the pathogenesis of atherosclerosis...
  100. ncbi request reprint C-reactive protein as a predictor for incident diabetes mellitus among middle-aged men: results from the MONICA Augsburg cohort study, 1984-1998
    Barbara Thorand
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Arch Intern Med 163:93-9. 2003
    ..Previous studies have suggested that low-grade systemic inflammation is involved in the pathogenesis of type 2 diabetes mellitus...
  101. ncbi request reprint High-sensitivity C-reactive protein and cardiovascular risk in patients with coronary heart disease
    Robert S Rosenson
    Preventive Cardiology Center, Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Curr Opin Cardiol 17:325-31. 2002
    ....