Alexander Koch

Summary

Affiliation: University Hospital
Country: Germany

Publications

  1. pmc Serum resistin levels in critically ill patients are associated with inflammation, organ dysfunction and metabolism and may predict survival of non-septic patients
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Crit Care 13:R95. 2009
  2. pmc Circulating soluble urokinase plasminogen activator receptor is stably elevated during the first week of treatment in the intensive care unit and predicts mortality in critically ill patients
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Crit Care 15:R63. 2011
  3. doi request reprint [Abnormal liver function tests in the intensive care unit]
    A Koch
    Medizinische Klinik III, Gastroenterologie, Stoffwechselerkrankungen und Internistische Intensivmedizin, Universitätsklinikum der RWTH Aachen, Pauwelsstr 30, 52072, Aachen, Deutschland
    Med Klin Intensivmed Notfmed 108:599-608; quiz 609-10. 2013
  4. doi request reprint [Treatment of inflammatory bowel disease in intensive care medicine]
    A Koch
    Medizinische Klinik III, Gastroenterologie, Stoffwechselerkrankungen und Internistische Intensivmedizin, Universitätsklinikum der RWTH Aachen
    Dtsch Med Wochenschr 137:1107-18; quiz 19-20. 2012
  5. pmc Regulation and prognostic relevance of serum ghrelin concentrations in critical illness and sepsis
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Crit Care 14:R94. 2010
  6. pmc Circulating retinol binding protein 4 in critically ill patients before specific treatment: prognostic impact and correlation with organ function, metabolism and inflammation
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Crit Care 14:R179. 2010
  7. ncbi request reprint Levels of circulating miR-133a are elevated in sepsis and predict mortality in critically ill patients
    Frank Tacke
    1Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany 2Department of Cardiology and Angiology, University of Kiel, Kiel, Germany
    Crit Care Med 42:1096-104. 2014
  8. pmc Regulation and prognostic relevance of symmetric dimethylarginine serum concentrations in critical illness and sepsis
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrase 30, 52074 Aachen, Germany
    Mediators Inflamm 2013:413826. 2013
  9. pmc Prognostic value of circulating amino-terminal pro-C-type natriuretic peptide in critically ill patients
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Crit Care 15:R45. 2011
  10. doi request reprint Serum adiponectin upon admission to the intensive care unit may predict mortality in critically ill patients
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    J Crit Care 26:166-74. 2011

Collaborators

Detail Information

Publications30

  1. pmc Serum resistin levels in critically ill patients are associated with inflammation, organ dysfunction and metabolism and may predict survival of non-septic patients
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Crit Care 13:R95. 2009
    ..We aimed to examine the correlation of serum resistin concentrations to parameters of inflammation, organ function, metabolism, disease severity and survival in critically ill patients...
  2. pmc Circulating soluble urokinase plasminogen activator receptor is stably elevated during the first week of treatment in the intensive care unit and predicts mortality in critically ill patients
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Crit Care 15:R63. 2011
    ....
  3. doi request reprint [Abnormal liver function tests in the intensive care unit]
    A Koch
    Medizinische Klinik III, Gastroenterologie, Stoffwechselerkrankungen und Internistische Intensivmedizin, Universitätsklinikum der RWTH Aachen, Pauwelsstr 30, 52072, Aachen, Deutschland
    Med Klin Intensivmed Notfmed 108:599-608; quiz 609-10. 2013
    ..Comprehensive diagnostic evaluation is essential to identify the underlying etiology of abnormal liver function tests and to initiate the appropriate therapeutic strategies. ..
  4. doi request reprint [Treatment of inflammatory bowel disease in intensive care medicine]
    A Koch
    Medizinische Klinik III, Gastroenterologie, Stoffwechselerkrankungen und Internistische Intensivmedizin, Universitätsklinikum der RWTH Aachen
    Dtsch Med Wochenschr 137:1107-18; quiz 19-20. 2012
    ....
  5. pmc Regulation and prognostic relevance of serum ghrelin concentrations in critical illness and sepsis
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Crit Care 14:R94. 2010
    ....
  6. pmc Circulating retinol binding protein 4 in critically ill patients before specific treatment: prognostic impact and correlation with organ function, metabolism and inflammation
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Crit Care 14:R179. 2010
    ..Retinol binding protein 4 (RBP4) promotes insulin resistance in mice and is systemically elevated in patients with obesity and type 2 diabetes. We investigated the potential role of RBP4 in critically ill patients...
  7. ncbi request reprint Levels of circulating miR-133a are elevated in sepsis and predict mortality in critically ill patients
    Frank Tacke
    1Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany 2Department of Cardiology and Angiology, University of Kiel, Kiel, Germany
    Crit Care Med 42:1096-104. 2014
    ..Serum levels of microRNA have been proposed as biomarkers in various inflammatory diseases. However, up to now, their clinical relevance in critical illness and sepsis is unclear...
  8. pmc Regulation and prognostic relevance of symmetric dimethylarginine serum concentrations in critical illness and sepsis
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrase 30, 52074 Aachen, Germany
    Mediators Inflamm 2013:413826. 2013
    ..Thus, the significant increase of circulating SDMA in critically ill patients indicates a potential pathogenic involvement in endothelial dysfunction during sepsis and may be useful for mortality risk stratification at the ICU. ..
  9. pmc Prognostic value of circulating amino-terminal pro-C-type natriuretic peptide in critically ill patients
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Crit Care 15:R45. 2011
    ..We aimed at evaluating the diagnostic and prognostic value of N-terminal pro-CNP (NT-proCNP) for predicting sepsis, disease severity and mortality in critically ill medical patients...
  10. doi request reprint Serum adiponectin upon admission to the intensive care unit may predict mortality in critically ill patients
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    J Crit Care 26:166-74. 2011
    ..We therefore investigated the potential pathogenic role and prognostic value of circulating adiponectin levels in critical illness...
  11. doi request reprint Longitudinal monocyte human leukocyte antigen-DR expression is a prognostic marker in critically ill patients with decompensated liver cirrhosis
    Marie Luise Berres
    Medical Department III, University Hospital Aachen, Aachen University, Aachen, Germany
    Liver Int 29:536-43. 2009
    ..Monocyte HLA-DR expression is decreased in cirrhotic patients, but its prognostic value has not been investigated prospectively...
  12. doi request reprint miR-133a mediates TGF-β-dependent derepression of collagen synthesis in hepatic stellate cells during liver fibrosis
    Christoph Roderburg
    Department of Medicine III, University of Aachen RWTH, 52074 Aachen, Germany
    J Hepatol 58:736-42. 2013
    ..miRNAs are novel regulators of organ fibrosis. miR-133a plays a role in cardiac and muscle remodeling, but its function in the liver is unclear. We therefore aimed at evaluating a possible function of miR-133a in hepatofibrogenesis...
  13. pmc Increased liver stiffness denotes hepatic dysfunction and mortality risk in critically ill non-cirrhotic patients at a medical ICU
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Crit Care 15:R266. 2011
    ..We investigated liver stiffness as a potentially useful tool for early detection of patients with hepatic deterioration and risk stratification with respect to short- and long-term mortality...
  14. pmc Circulating microRNA-150 serum levels predict survival in patients with critical illness and sepsis
    Christoph Roderburg
    Department of Medicine III, University Hospital Rheinisch Westfaelische Technische Hochschule Aachen, Aachen, Germany
    PLoS ONE 8:e54612. 2013
    ..We thus aimed at evaluating the diagnostic and prognostic value of miR-150 serum levels in patients with critically illness and sepsis...
  15. doi request reprint Serum NT-proCNP concentrations are elevated in patients with chronic liver diseases and associated with complications and unfavorable prognosis of cirrhosis
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Clin Biochem 45:429-35. 2012
    ..C-type natriuretic peptide (CNP) might be an important regulator of vasodilatation, fluid and sodium balance in liver cirrhosis. We aimed at assessing its regulation and prognostic relevance in liver disease patients...
  16. ncbi request reprint Serum concentrations of A Proliferation-Inducing Ligand (APRIL) are elevated in sepsis and predict mortality in critically ill patients
    Christoph Roderburg
    Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany
    J Crit Care 28:882.e1-11. 2013
    ..However, up to now, APRIL has not been investigated in critical illness or sepsis. We therefore analyzed APRIL serum concentrations in a large cohort of well-characterized intensive care unit patients...
  17. doi request reprint Elevated asymmetric dimethylarginine levels predict short- and long-term mortality risk in critically ill patients
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, Aachen, Germany
    J Crit Care 28:947-53. 2013
    ..We aimed at investigating ADMA levels as a potential diagnostic or prognostic biomarker in critically ill patients...
  18. doi request reprint High C5a levels are associated with increased mortality in sepsis patients--no enhancing effect by actin-free Gc-globulin
    Olav A Gressner
    Institute of Clinical Chemistry and Pathobiochemistry, University Hospital Aachen, Aachen University RWTH, Aachen, Germany
    Clin Biochem 41:974-80. 2008
    ..Immune paralysis of phagocytic cells due to excess of the complement activation product C5a has been proposed as a critical pathomechanism in sepsis. In vitro studies suggest an interaction of C5a with Group-specific globulin (Gc-globulin)...
  19. pmc U6 is unsuitable for normalization of serum miRNA levels in patients with sepsis or liver fibrosis
    Fabian Benz
    Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany
    Exp Mol Med 45:e42. 2013
    ..Further studies are warranted to identify specific regulatory processes of U6 levels in sepsis and liver fibrosis. ..
  20. ncbi request reprint Administration of proton pump inhibitors in critically ill medical patients is associated with increased risk of developing Clostridium difficile-associated diarrhea
    Lukas Buendgens
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    J Crit Care 29:696.e11-5. 2014
    ..In non-ICU hospitalized patients, PPI administration increases the risk of infectious complications, especially Clostridium difficile-associated diarrhea (CDAD); but no such data are available for the ICU setting...
  21. doi request reprint Circulating soluble urokinase plasminogen activator is elevated in patients with chronic liver disease, discriminates stage and aetiology of cirrhosis and predicts prognosis
    Henning W Zimmermann
    Department of Medicine, RWTH University Hospital Aachen, Aachen, Germany
    Liver Int 32:500-9. 2012
    ..High serum concentrations of soluble uPAR (suPAR) are suggested to reflect activated immune cells...
  22. ncbi request reprint Lessons from a patient with an unusual hepatic overlap syndrome
    Leif E Sander
    Department of Internal Medicine III, Aachen University Hospital, Aachen, Germany
    Nat Clin Pract Gastroenterol Hepatol 4:635-40. 2007
    ....
  23. doi request reprint Simultaneous placement of multiple central lines increases central line-associated bloodstream infection rates
    Simone Scheithauer
    Departments of Infection Control and Infectious Diseases, University Hospital Aachen, RWTH Aachen, Aachen, Germany
    Am J Infect Control 41:113-7. 2013
    ..In this study, we tested the hypothesis that simultaneous placement of more than 1 CL is associated with an increased CLABSI rate...
  24. pmc Micro-RNA profiling in human serum reveals compartment-specific roles of miR-571 and miR-652 in liver cirrhosis
    Christoph Roderburg
    Department of Medicine III, University Hospital RWTH Aachen, Aachen, Germany
    PLoS ONE 7:e32999. 2012
    ..Therefore, in the present study we performed a systematic screening approach in order to identify miRNAs with altered levels in the serum of patients with chronic liver disease and liver cirrhosis...
  25. ncbi request reprint Profuse rectal bleeding of no visible cause
    Andreas Geier
    Department of Internal Medicine III, Aachen University, University Hospital, D 52074 Aachen, Germany
    Lancet 369:1664. 2007
  26. ncbi request reprint Hyperglycemia at admission to the intensive care unit is associated with elevated serum concentrations of interleukin-6 and reduced ex vivo secretion of tumor necrosis factor-alpha
    Hermann E Wasmuth
    Department of Medicine III, University Hospital Aachen, Aachen University RWTH, Aachen, Germany
    Crit Care Med 32:1109-14. 2004
    ..The aim of the study was to investigate the association between admission blood glucose concentrations and immune function variables and its correlation to mortality rate in patients of a medical intensive care unit...
  27. doi request reprint Compliance with hand hygiene on surgical, medical, and neurologic intensive care units: direct observation versus calculated disinfectant usage
    Simone Scheithauer
    Department of Infection Control and Infectious Diseases, III University Hospital Aachen, 52074 Aachen, Germany
    Am J Infect Control 37:835-41. 2009
    ..Although there have been several reports on compliance rates (CRs) to HH recommendations, data for intensive care units (ICUs) in general and for shift- and indication-specific opportunities in particular are scarce...
  28. doi request reprint Semi-automated measurement of hyperdense, hypodense and heterogeneous hepatic metastasis on standard MDCT slices. Comparison of semi-automated and manual measurement of RECIST and WHO criteria
    Sebastian Keil
    Department of Diagnostic Radiology, University Hospital, RWTH Aachen University, Aachen, Germany
    Eur Radiol 18:2456-65. 2008
    ..94 (heterogeneous); WHO area: 0.95, 0.98, 0.93]. Semi-automatic measurement of hyperdense, hypodense and heterogeneous liver metastases showed reliable results on standard axial reconstructions in comparison to manual quantification...
  29. pmc Why high suPAR is not super - diagnostic, prognostic and potential pathogenic properties of a novel biomarker in the ICU
    Alexander Koch
    Department of Medicine III, RWTH University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Crit Care 15:1020. 2011
    ..This study expands our knowledge of the diagnostic power of suPAR, confirms its prognostic value, and raises the demand for future studies investigating the pathogenic involvement of suPAR...