M Knuf

Summary

Affiliation: University of Mainz
Country: Germany

Publications

  1. ncbi request reprint Tolerability of the Biken acellular pertussis vaccine in adults with or without previous vaccination against pertussis in childhood
    Markus Knuf
    Pediatric Immunology and Infectious Diseases, Center of Preventive Pediatrics, Johannes Gutenberg University, Mainz, Germany
    Med Klin (Munich) 99:495-9. 2004
  2. ncbi request reprint [Sense and nonsense of exposure prophylaxis in communal club installations for children and adolescents -- a contribution to the implementation of the German Defence Against Infection law from a point of view of preventive paediatrics]
    M Knuf
    Universitäts Kinderklinik Mainz
    Gesundheitswesen 64:669-74. 2002
  3. doi request reprint Neonatal vaccination with an acellular pertussis vaccine accelerates the acquisition of pertussis antibodies in infants
    Markus Knuf
    Paediatric Immunology and Infectious Diseases, Children s Hospital, Johannes Gutenberg University of Mainz, Mainz, Germany
    J Pediatr 152:655-60, 660.e1. 2008
  4. ncbi request reprint ["Childhood illnesses" 2002]
    M Knuf
    Zentrum für Präventive Pädiatrie, Johannes Gutenberg Universitat Mainz, Germany
    HNO 50:1005-11. 2002
  5. ncbi request reprint Immunogenicity and safety of two doses of tetravalent measles-mumps-rubella-varicella vaccine in healthy children
    Markus Knuf
    Childrens Hospital, Johannes Gutenberg University Hospital, Mainz, Germany
    Pediatr Infect Dis J 25:12-8. 2006
  6. ncbi request reprint Assessment of nine candidate DTP-vaccines with reduced amount of antigen and/or without adjuvant as a fourth (booster-) dose in the second year of life
    M Knuf
    Paediatric Infectious Diseases at the Zentrum Präventive Pädiatrie, Department of Paediatrics at the Johannes Gutenberg University, Langenbeckstrasse 1, 55101 Mainz, Germany
    Vaccine 24:5627-36. 2006
  7. doi request reprint Booster vaccination after neonatal priming with acellular pertussis vaccine
    Markus Knuf
    Department of Pediatrics, Johannes Gutenberg University, Mainz, Germany
    J Pediatr 156:675-8. 2010
  8. ncbi request reprint [Impact of universal varicella vaccination in Germany: an epidemiological and economic analysis]
    M Knuf
    Kinderklinik und Kinderpoliklinik, Johannes Gutenberg Universitat, Langenbeckstrasse 1, 55101 Mainz
    Klin Padiatr 218:203-12. 2006
  9. ncbi request reprint A combination vaccine against measles, mumps, rubella and varicella
    Markus Knuf
    Pediatric University Hospital, Johannes Gutenberg University, Mainz, Germany
    Drugs Today (Barc) 44:279-92. 2008
  10. ncbi request reprint Evidence for induction of polysaccharide specific B-cell-memory in the 1st year of life: plain Haemophilus influenzae type b-PRP (Hib) boosters children primed with a tetanus-conjugate Hib-DTPa-HBV combined vaccine
    F Zepp
    Children s Hospital, Johannes Gutenberg University, Mainz, Germany
    Eur J Pediatr 156:18-24. 1997

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Tolerability of the Biken acellular pertussis vaccine in adults with or without previous vaccination against pertussis in childhood
    Markus Knuf
    Pediatric Immunology and Infectious Diseases, Center of Preventive Pediatrics, Johannes Gutenberg University, Mainz, Germany
    Med Klin (Munich) 99:495-9. 2004
    ..The results from this study were compared to data from published literature...
  2. ncbi request reprint [Sense and nonsense of exposure prophylaxis in communal club installations for children and adolescents -- a contribution to the implementation of the German Defence Against Infection law from a point of view of preventive paediatrics]
    M Knuf
    Universitäts Kinderklinik Mainz
    Gesundheitswesen 64:669-74. 2002
    ..Before integration of children into such facilities it should be necessary to verify that there are no doubts about the health conditions. This could be confirmed by presenting the vaccination or check-up card...
  3. doi request reprint Neonatal vaccination with an acellular pertussis vaccine accelerates the acquisition of pertussis antibodies in infants
    Markus Knuf
    Paediatric Immunology and Infectious Diseases, Children s Hospital, Johannes Gutenberg University of Mainz, Mainz, Germany
    J Pediatr 152:655-60, 660.e1. 2008
    ..Because young infants are at highest risk of pertussis complications, this study assessed whether neonatal acellular pertussis (aP) vaccination could provide earlier immunity...
  4. ncbi request reprint ["Childhood illnesses" 2002]
    M Knuf
    Zentrum für Präventive Pädiatrie, Johannes Gutenberg Universitat Mainz, Germany
    HNO 50:1005-11. 2002
  5. ncbi request reprint Immunogenicity and safety of two doses of tetravalent measles-mumps-rubella-varicella vaccine in healthy children
    Markus Knuf
    Childrens Hospital, Johannes Gutenberg University Hospital, Mainz, Germany
    Pediatr Infect Dis J 25:12-8. 2006
    ....
  6. ncbi request reprint Assessment of nine candidate DTP-vaccines with reduced amount of antigen and/or without adjuvant as a fourth (booster-) dose in the second year of life
    M Knuf
    Paediatric Infectious Diseases at the Zentrum Präventive Pädiatrie, Department of Paediatrics at the Johannes Gutenberg University, Langenbeckstrasse 1, 55101 Mainz, Germany
    Vaccine 24:5627-36. 2006
    ..Lowering the amount of antigen or of adjuvant may decrease the reactogenicity of DTaP while maintaining a protective immune response...
  7. doi request reprint Booster vaccination after neonatal priming with acellular pertussis vaccine
    Markus Knuf
    Department of Pediatrics, Johannes Gutenberg University, Mainz, Germany
    J Pediatr 156:675-8. 2010
    ..Thus, neonatal aP priming did not lead to immune tolerance to pertussis antigens. However, it elicited bystander interference on HBV, Hib, and diphtheria responses...
  8. ncbi request reprint [Impact of universal varicella vaccination in Germany: an epidemiological and economic analysis]
    M Knuf
    Kinderklinik und Kinderpoliklinik, Johannes Gutenberg Universitat, Langenbeckstrasse 1, 55101 Mainz
    Klin Padiatr 218:203-12. 2006
    ..From these findings it can be concluded that universal varicella vaccination is a strategy which should be encouraged, from a medical, epidemiological, but also economic viewpoint...
  9. ncbi request reprint A combination vaccine against measles, mumps, rubella and varicella
    Markus Knuf
    Pediatric University Hospital, Johannes Gutenberg University, Mainz, Germany
    Drugs Today (Barc) 44:279-92. 2008
    ..For other countries considering introducing these vaccines, the advantages for children, parents and healthcare providers of protecting against four diseases in a single vaccine should be noted...
  10. ncbi request reprint Evidence for induction of polysaccharide specific B-cell-memory in the 1st year of life: plain Haemophilus influenzae type b-PRP (Hib) boosters children primed with a tetanus-conjugate Hib-DTPa-HBV combined vaccine
    F Zepp
    Children s Hospital, Johannes Gutenberg University, Mainz, Germany
    Eur J Pediatr 156:18-24. 1997
    ..5% of vaccinees, and immune responses to each of the acellular pertussis vaccine components in 92.3%-97.3% of subjects...
  11. ncbi request reprint Immunogenicity and reactogenicity of a Haemophilus influenzae type b tetanus conjugate vaccine when administered separately or mixed with concomitant diphtheria-tetanus-toxoid and acellular pertussis vaccine for primary and for booster immunizations
    H J Schmitt
    Children s Hospital, Johannes Gutenberg University, Mainz, Germany
    Eur J Pediatr 157:208-14. 1998
    ..15 microg/ml and there was a marked booster response (> 100-fold) in all groups...
  12. ncbi request reprint Cellular immune response of a varicella vaccine following simultaneous DTaP and VZV vaccination
    P Habermehl
    Pediatric Immunology and Infectious Diseases, Johannes Gutenberg University, Mainz, Germany
    Vaccine 17:669-74. 1999
    ....
  13. pmc Pertussis-specific cell-mediated immunity in infants after vaccination with a tricomponent acellular pertussis vaccine
    F Zepp
    Pediatric Immunology and Infectious Diseases, Children s Hospital, Johannes Gutenberg University of Mainz, Germany
    Infect Immun 64:4078-84. 1996
    ..Cell-mediated immunity requires further study, particularly to improve our understanding of the persistence of protection afforded by vaccination up to the administration of booster doses...
  14. ncbi request reprint Immunogenicity, reactogenicity and safety of a 7-valent pneumococcal conjugate vaccine (PCV7) concurrently administered with a DTPa-HBV-IPV/Hib combination vaccine in healthy infants
    M Knuf
    Pediatric Infectious Disease, Johannes Gutenberg University, Langenbeckstr 1, D 55101 Mainz, Germany
    Vaccine 24:4727-36. 2006
    ....
  15. ncbi request reprint Safety of reduced-antigen-content tetanus-diphtheria-acellular pertussis vaccine in adolescents as a sixth consecutive dose of acellular pertussis-containing vaccine
    Fred Zepp
    Children s Hospital, Johannes Gutenberg University, Mainz, Germany
    J Pediatr 149:603-610. 2006
    ..The safety of a booster dose of a reduced-antigen-content tetanus-diphtheria-acellular pertussis (Tdap) vaccine was evaluated in adolescents previously vaccinated with five doses of acellular pertussis-containing vaccine...
  16. ncbi request reprint Immunogenicity of a single dose of reduced-antigen acellular pertussis vaccine in a non-vaccinated adolescent population
    Markus Knuf
    Department of Pediatrics, Johannes Gutenberg University of Mainz, Germany
    Vaccine 24:2043-8. 2006
    ..IgA-anti-PT and IgA-anti-FHA responses were found in 43 and 81% of subjects, respectively. This study shows that in unvaccinated German adolescents pertussis immunity can be achieved by a single dose of Tdap...
  17. ncbi request reprint Safety, reactogenicity and immunogenicity of a combined hexavalent tetanus, diphtheria, acellular pertussis, hepatitis B, inactivated poliovirus vaccine and Haemophilus influenzae type b conjugate vaccine, for primary immunization of infants
    F Zepp
    Children s Hospital, Johannes Gutenberg University, Langenbeckstrasse 1, 55101 Mainz, Germany
    Vaccine 22:2226-33. 2004
    ....
  18. doi request reprint Immunogenicity of routinely used childhood vaccines when coadministered with the 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV)
    Markus Knuf
    Zentrum für Kinder und Jugendmedizin, Johannes Gutenberg Universitat Mainz, Mainz, Germany
    Pediatr Infect Dis J 28:S97-S108. 2009
    ....
  19. pmc Normal values of M mode echocardiographic measurements of more than 2000 healthy infants and children in central Europe
    C Kampmann
    Johannes Gutenberg University, Department of Paediatric Cardiology, Langenbeckstrasse 1, D 55101 Mainz, Germany
    Heart 83:667-72. 2000
    ..To obtain normal M mode (one dimensional) echocardiographic values in a substantial sample of normal infants and children...
  20. ncbi request reprint Identification of a novel compound heterozygote SCO2 mutation in cytochrome c oxidase deficient fatal infantile cardioencephalomyopathy
    M Knuf
    Children s Hospital, Johannes Gutenberg University, Mainz, Germany
    Acta Paediatr 96:130-2. 2007
    ..CONCLUSION: In newborns with unexplained muscular hypotonia and cardiomyopathy genetic testing of mitochondrial respiratory chain disorders might be helpful to establish a final diagnosis and guide treatment decisions...
  21. doi request reprint A dose-range study assessing immunogenicity and safety of one dose of a new candidate meningococcal serogroups A, C, W-135, Y tetanus toxoid conjugate (MenACWY-TT) vaccine administered in the second year of life and in young children
    M Knuf
    Zentrum für Kinder und Jugendmedizin, Johannes Gutenberg University, Germany
    Vaccine 28:744-53. 2010
    ..The safety profile was comparable to licensed controls. The new ACWY-TT conjugate vaccine promises high seroprotection levels against meningococcal disease from 1 year of age...
  22. ncbi request reprint Cell mediated and antibody immune response to inactivated hepatitis A vaccine
    P Schmidtke
    Pediatric Immunology and Infectious Diseases, Children s Hospital, University of Mainz, Obere Zahlbacher Str 63, DMG, 55131 Mainz, Germany
    Vaccine 23:5127-32. 2005
    ..The booster vaccination-induced immediate peak levels for the humoral (anti-HAV GMC=5376mIU/ml) as well as the cellular (median Deltacpm=14173cpm) response...
  23. ncbi request reprint [Preparation of a compatibility chart for intravenous drug therapy in neonatal and pediatric intensive care units]
    J H Höpner
    Interdisziplinäre Pädiatrische Intensivstation, Kinderklinik und Poliklinik der Johannes Gutenberg Universität Mainz, Germany
    Klin Padiatr 219:37-43. 2007
    ....
  24. ncbi request reprint Flow-cytometric DNA analysis of intracranial tumors in children
    P Habermehl
    Pediatric Hospital and Ambulant Clinic of Johannes Gutenberg University Mainz, Germany
    Pathol Res Pract 200:197-202. 2004
    ..The small size of this study could not establish flow cytometry as a definite prognostic factor, but further prospective multicenter studies will evaluate the prognostic significance of flow-cytometric DNA analysis...
  25. ncbi request reprint [Anaphylaxis after vaccination due to hypersensitivity to gelatin]
    W Kamin
    Kinderklinik der Johannes Gutenberg Universität Mainz
    Klin Padiatr 218:92-4. 2006
    ..If type 1 reactions after vaccination occur, gelatin should be taken into account as the causative agent. A medical alert card is recommended for such patients...
  26. ncbi request reprint [Transcatheter occlusion of the persisting arterial duct]
    Ch Kampmann
    Kinderkardiologie der Universitätskinderklinik
    Klin Padiatr 214:303-8. 2002
    ..Comparative studies with this devices in relation to the size of the PDA and the device are missing. Aim of this study was to evaluate the different systems at the own patient population...
  27. ncbi request reprint Immunogenicity of reduced antigen content tetanus-diphtheria-acellular pertussis vaccine in adolescents as a sixth consecutive dose of acellular pertussis-containing vaccine
    Fred Zepp
    Children s Hospital, Johannes Gutenberg University, Langenbeckstrasse 1, 55101 Mainz, Germany
    Vaccine 25:5248-52. 2007
    ..After the sixth dose booster, Tdap induced a vigorous immune response, consistent with protection against diphtheria, tetanus and pertussis diseases...
  28. doi request reprint A toll-like receptor 4 variant is associated with fatal outcome in children with invasive meningococcal disease
    Joerg Faber
    Children s Hospital, University of Mainz, Mainz, Germany
    Acta Paediatr 98:548-52. 2009
    ..Here, we analysed a possible association between the TLR4 variant Asp299Gly and disease outcome in children with invasive meningococcal disease...
  29. ncbi request reprint Mid-term results of a modified arterial switch operation using the direct reconstruction technique of the pulmonary artery
    Włodzimierz Kuroczyński
    Department of Cardiothoracic and Vascular Surgery, University Hopsital Mainz, Germany
    Cardiol J 17:574-9. 2010
    ..We report a single-surgeon series of mid-term results for direct pulmonary artery anastomosis during switch operation for transposition of the great arteries (TGA)...
  30. ncbi request reprint Immunogenicity and reactogenicity of acellular pertussis booster vaccines in children: standard pediatric versus a reduced-antigen content formulation
    Claudius U Meyer
    Pediatric Immunology and Infectious Diseases, Children s Hospital, Johannes Gutenberg University of Mainz, Mainz, Germany
    Hum Vaccin 4:203-9. 2008
    ..Non-significant trends toward reduced reactogenicity of dTpa were observed. Many factors influence vaccine choice at preschool age. The dTpa vaccine was as immunogenic and possibly better tolerated than DTPa at this age...
  31. pmc Efficient maturation and cytokine production of neonatal DCs requires combined proinflammatory signals
    Doreen Krumbiegel
    Department of Pediatric Immunology and Infectious Diseases, Children s Hospital, Johannes Gutenberg University, 55131 Mainz, Germany
    Clin Dev Immunol 12:99-105. 2005
    ..In conclusion, neonatal DCs can be stimulated to express maturation as well as costimulatory surface molecules. However, induction of maturation requires combined stimulation with multiple proinflammatory signals...
  32. ncbi request reprint Changes in lymphocyte subsets after cardiac surgery in children
    Pirmin Habermehl
    Department of Paediatrics, University of Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
    Eur J Pediatr 162:15-21. 2003
    ..In contrast, the proportion of T-cells expressing activation markers (CD25, CD45R0) decreased within 24 h after CPB, as did the number of cells expressing adhesion molecules (CD11b and ICAM)...
  33. ncbi request reprint Human toll-like receptor 4 mutations are associated with susceptibility to invasive meningococcal disease in infancy
    Joerg Faber
    Children s Hospital, Johannes Gutenberg University, Mainz, Germany
    Pediatr Infect Dis J 25:80-1. 2006
    ..007) was observed. We conclude that TLR4 mutations represent a risk factor for meningococcal disease in this age group...
  34. ncbi request reprint Late results after PTCA for coronary stenosis after the arterial switch procedure for transposition of the great arteries
    Christoph Kampmann
    Division of Pediatric Cardiology, Hospital for Sick Children, Mainz, Germany
    Ann Thorac Surg 80:1641-6. 2005
    ..Late results after percutaneous transluminal coronary angioplasty (PTCA) for coronary stenosis after the arterial switch operation for d-transposition of the great arteries are reported...
  35. ncbi request reprint Biodegradation of tungsten embolisation coils used in children
    Christoph Kampmann
    Division of Paediatric Cardiology, University Children s Hospital of Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
    Pediatr Radiol 32:839-43. 2002
    ..It has been suggested that tungsten coils (TCs) may corrode 30 months after transcatheter embolisation (TCE). The aim of this study was to follow up children after TCE of aorto-pulmonary collaterals (APCs) with TCs...
  36. doi request reprint Two versus three doses of a meningococcal C conjugate vaccine concomitantly administered with a hexavalent DTaP-IPV-HBV/Hib vaccine in healthy infants
    Heinz J Schmitt
    Zentrum für Präventive Pädiatrie, Kinderklinik, Johannes Gutenberg Universitat Mainz, Langenbeckstrabe 1, 55131 Mainz, Germany
    Vaccine 26:2242-52. 2008
    ..Reactogenicity was similar in each group. MenC conjugate vaccine given concomitantly with DTaP-IPV-HBV/Hib to healthy infants in the first year of life using a two-dose schedule is as safe and immunogenic as a three-dose regimen...
  37. ncbi request reprint The interaction of buccal mucosal epithelial cells with E. coli bacteria enhances the intraepithelial calcium flux and the release of prostaglandin E2 (PgE2)
    W Mannhardt
    Department of Pediatrics, University of Mainz, Germany
    Int Urogynecol J Pelvic Floor Dysfunct 10:308-15. 1999
    ..The resulting cell activation may lead to the secretion of antimicrobial peptides, thereby contributing to the regulation of mucosal host resistance to bacterial infections...
  38. ncbi request reprint Significance of patient categorization for perioperative management of children with tetralogy of Fallot, with special regard to co-existing malformations
    Markus Knuf
    University of Mainz, Children s Hospital, Mainz, Germany
    Cardiol J 17:20-8. 2010
    ..The aim of our study was to facilitate perioperative calculation of potential risk factors on the outcome of corrective surgery for children with tetralogy of Fallot...
  39. doi request reprint Validation of a multiplex reverse transcriptase PCR ELISA for the detection of 19 respiratory tract pathogens
    W Puppe
    Pediatric Infectious Diseases, Department of Pediatrics, University Hospital Schleswig Holstein, Campus Kiel, Schwanenweg 20, 24105, Kiel, Germany
    Infection 41:77-91. 2013
    ....
  40. ncbi request reprint Adjustable tourniquet to manipulate pulmonary blood flow after Norwood operations
    F X Schmid
    Department of Cardiothoracic Surgery, Johannes Gutenberg University Hospitals, Mainz, Germany
    Ann Thorac Surg 68:2306-9. 1999
    ..Here we report the clinical results using a modified technique that allows a controlled systemic-to-pulmonary shunt flow to prevent pulmonary overcirculation...
  41. ncbi request reprint The right ventricle in Fabry disease
    C Kampmann
    Department of Cardiology, University Children s Hospital, Mainz, Germany
    Acta Paediatr Suppl 94:15-8; discussion 9-10. 2005
    ..To date, however, little is known about the role of right ventricular (RV) function in Fabry disease. Therefore, this study aimed to investigate the extent of RV involvement in patients with Fabry disease...
  42. ncbi request reprint Age-dependent association of human mannose-binding lectin mutations with susceptibility to invasive meningococcal disease in childhood
    Joerg Faber
    Children s Hospital, Johannes Gutenberg University, Mainz, Germany
    Pediatr Infect Dis J 26:243-6. 2007
    ..Mannose-binding lectin (MBL) is an important factor of the innate immune system, and MBL-initiated complement activation is an important early defense mechanism against various bacterial infections, including invasive meningococcal disease...
  43. pmc Immunogenicity, reactogenicity, and immune memory after primary vaccination with a novel Haemophilus influenzae-Neisseria meningitidis serogroup C conjugate vaccine
    Heinz J Schmitt
    Johannes Gutenberg Universitat, Langenbeckstr 1, 55101 Mainz, Germany
    Clin Vaccine Immunol 14:426-34. 2007
    ..A Hib-MenC-TT conjugate vaccine provides vaccination against two major pathogens in a single injection and is a suitable candidate for use in primary or booster vaccination schedules...
  44. ncbi request reprint Linking C5 deficiency to an exonic splicing enhancer mutation
    Nicole Pfarr
    Children s Hospital of Johannes Gutenberg University of Mainz, Mainz, Germany
    J Immunol 174:4172-7. 2005
    ..This apparently inconsequential sequence alteration represents a noncanonical splicing mutation altering an ESE. Our finding sheds a new light on the role of putative silent/conservative mutations in disease-associated genes...
  45. doi request reprint Rapid detection of common pathogenic Aspergillus species by a novel real-time PCR approach
    Joerg Faber
    Children s Hospital, University of Mainz, Mainz, Germany
    Mycoses 52:228-33. 2009
    ..We describe a highly specific and sensitive real-time PCR approach to detect and differentiate the most common pathogenic Aspergillus species in a rapid 'same day' assay...
  46. ncbi request reprint Evaluation of the immunogenicity and reactogenicity of a DTPa-HBV-IPV Combination vaccine co-administered with a Hib conjugate vaccine either as a single injection of a hexavalent combination or as two separate injections at 3, 5 and 11 months of age
    Giovanni Gabutti
    Laboratory of Hygiene, Di S Te B A University of Lecce, Lecce, Italy
    Scand J Infect Dis 36:585-92. 2004
    ....