Uwe Knippschild

Summary

Affiliation: University of Ulm
Country: Germany

Publications

  1. ncbi request reprint The role of the casein kinase 1 (CK1) family in different signaling pathways linked to cancer development
    Uwe Knippschild
    Department of Visceral and Transplantation Surgery, University of Ulm, Germany
    Onkologie 28:508-14. 2005
  2. ncbi request reprint The casein kinase 1 family: participation in multiple cellular processes in eukaryotes
    Uwe Knippschild
    Department of Visceral and Transplantation Surgery, University of Ulm, Steinhovelstr 9, 89075 Ulm, Germany
    Cell Signal 17:675-89. 2005
  3. ncbi request reprint Casein kinase 1 delta (CK1delta) interacts with the SNARE associated protein snapin
    Sonja Wolff
    Clinic of General, Visceral and Transplantation Surgery, the Medical University of Ulm, Steinhovelstr 9, 89075 Ulm, Germany
    FEBS Lett 580:6477-84. 2006
  4. pmc 2-Benzamido-N-(1H-benzo[d]imidazol-2-yl)thiazole-4-carboxamide derivatives as potent inhibitors of CK1δ/ε
    Joachim Bischof
    Department of General, Visceral and Transplantation Surgery, Surgery Centre, University of Ulm, Steinhövel Str 9, 89075, Ulm, Germany
    Amino Acids 43:1577-91. 2012
  5. pmc Impaired CK1 delta activity attenuates SV40-induced cellular transformation in vitro and mouse mammary carcinogenesis in vivo
    Heidrun Hirner
    Department of General, Visceral and Transplantation Surgery, University of Ulm, Ulm, Germany
    PLoS ONE 7:e29709. 2012
  6. pmc Phosphorylation at Ser244 by CK1 determines nuclear localization and substrate targeting of PKD2
    J von Blume
    Department of Internal Medicine I, University of Ulm, Ulm, Germany
    EMBO J 26:4619-33. 2007
  7. pmc Phosphorylation of CK1delta: identification of Ser370 as the major phosphorylation site targeted by PKA in vitro and in vivo
    Georgios Giamas
    Clinic of General, Visceral and Transplantation Surgery, University of Ulm, Steinhoevelstr 9, 89075 Ulm, Germany
    Biochem J 406:389-98. 2007
  8. pmc RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J
    Stephan Armin Wacker
    Institute of Biochemistry, Department of Internal Medicine I, University of Ulm, Ulm, Germany
    EMBO J 30:43-56. 2011
  9. doi request reprint Inhibition of pancreatic cancer cell growth in vivo using a tetracycline-inducible cyclin D1 antisense expression system
    Jian Cheng Wang
    Department of General, Visceral, and Transplantation Surgery, University of Ulm, Ulm, Germany
    Pancreas 42:141-8. 2013
  10. ncbi request reprint Protein kinases as targets for cancer treatment
    Georgios Giamas
    Clinic of General, Visceral and Transplantation Surgery, University of Ulm, 89075 Ulm, Germany
    Pharmacogenomics 8:1005-16. 2007

Collaborators

Detail Information

Publications20

  1. ncbi request reprint The role of the casein kinase 1 (CK1) family in different signaling pathways linked to cancer development
    Uwe Knippschild
    Department of Visceral and Transplantation Surgery, University of Ulm, Germany
    Onkologie 28:508-14. 2005
    ..In this review, we summarize the functions of CK1 and outline the participation of CK1 in signal transduction pathways linked to cancer development...
  2. ncbi request reprint The casein kinase 1 family: participation in multiple cellular processes in eukaryotes
    Uwe Knippschild
    Department of Visceral and Transplantation Surgery, University of Ulm, Steinhovelstr 9, 89075 Ulm, Germany
    Cell Signal 17:675-89. 2005
    ..This review will summarize our current knowledge about the function and regulation of mammalian CK1 isoforms...
  3. ncbi request reprint Casein kinase 1 delta (CK1delta) interacts with the SNARE associated protein snapin
    Sonja Wolff
    Clinic of General, Visceral and Transplantation Surgery, the Medical University of Ulm, Steinhovelstr 9, 89075 Ulm, Germany
    FEBS Lett 580:6477-84. 2006
    ..The identification of snapin as a new substrate of CK1delta points towards a possible function for CK1delta in modulating snapin specific functions...
  4. pmc 2-Benzamido-N-(1H-benzo[d]imidazol-2-yl)thiazole-4-carboxamide derivatives as potent inhibitors of CK1δ/ε
    Joachim Bischof
    Department of General, Visceral and Transplantation Surgery, Surgery Centre, University of Ulm, Steinhövel Str 9, 89075, Ulm, Germany
    Amino Acids 43:1577-91. 2012
    ..In summary, our optimizations lead to the development of new highly selective CK1δ and ε specific inhibitors with biological activity...
  5. pmc Impaired CK1 delta activity attenuates SV40-induced cellular transformation in vitro and mouse mammary carcinogenesis in vivo
    Heidrun Hirner
    Department of General, Visceral and Transplantation Surgery, University of Ulm, Ulm, Germany
    PLoS ONE 7:e29709. 2012
    ..Our data show that inactivating mutations in CK1δ impair SV40-induced cellular transformation in vitro and mouse mammary carcinogenesis in vivo...
  6. pmc Phosphorylation at Ser244 by CK1 determines nuclear localization and substrate targeting of PKD2
    J von Blume
    Department of Internal Medicine I, University of Ulm, Ulm, Germany
    EMBO J 26:4619-33. 2007
    ....
  7. pmc Phosphorylation of CK1delta: identification of Ser370 as the major phosphorylation site targeted by PKA in vitro and in vivo
    Georgios Giamas
    Clinic of General, Visceral and Transplantation Surgery, University of Ulm, Steinhoevelstr 9, 89075 Ulm, Germany
    Biochem J 406:389-98. 2007
    ..In summary, we conclude that PKA phosphorylates CK1delta, predominantly at Ser370 in vitro and in vivo, and that site-specific phosphorylation of CK1delta by PKA plays an important role in modulating CK1delta-dependent processes...
  8. pmc RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J
    Stephan Armin Wacker
    Institute of Biochemistry, Department of Internal Medicine I, University of Ulm, Ulm, Germany
    EMBO J 30:43-56. 2011
    ..Thus, we propose that RITA acts as a negative modulator of the Notch signalling pathway, controlling the level of nuclear RBP-J/CBF-1, where its amounts are limiting...
  9. doi request reprint Inhibition of pancreatic cancer cell growth in vivo using a tetracycline-inducible cyclin D1 antisense expression system
    Jian Cheng Wang
    Department of General, Visceral, and Transplantation Surgery, University of Ulm, Ulm, Germany
    Pancreas 42:141-8. 2013
    ..Cyclin D1 is important for pancreatic cancer growth. Our aim was to determine the effects of cyclin D1 inhibition on the growth of established pancreatic tumors...
  10. ncbi request reprint Protein kinases as targets for cancer treatment
    Georgios Giamas
    Clinic of General, Visceral and Transplantation Surgery, University of Ulm, 89075 Ulm, Germany
    Pharmacogenomics 8:1005-16. 2007
    ..In this review, the specificity, mechanism of action and antitumor activity of several new small-molecule inhibitors of tyrosine and serine/threonine kinases are discussed...
  11. pmc Neurite outgrowth of mature retinal ganglion cells and PC12 cells requires activity of CK1δ and CK1ε
    Joachim Bischof
    Department of General, Visceral and Transplantation Surgery, University of Ulm, Ulm, Germany
    PLoS ONE 6:e20857. 2011
    ..These data provide evidence for a so far unknown, but essential role of CK1 isoforms in neurite growth...
  12. doi request reprint Stimulation of axon regeneration in the mature optic nerve by intravitreal application of the toll-like receptor 2 agonist Pam3Cys
    Thomas G Hauk
    Department of Experimental Neurology, University of Ulm, Ulm, Germany
    Invest Ophthalmol Vis Sci 51:459-64. 2010
    ....
  13. pmc Prognostic relevance of hTERT mRNA expression in ductal adenocarcinoma of the pancreas
    Lukasz Filip Grochola
    Department of General, Visceral and Transplantation Surgery, The University Hospital of Ulm, 89075 Ulm, Germany
    Neoplasia 10:973-6. 2008
    ..These data challenge previous findings outlining hTERT's negative impact on overall survival. The risk pattern obtained in PDAC suggests a more complex regulation of hTERT...
  14. ncbi request reprint Interaction of casein kinase 1 delta (CK1 delta) with the light chain LC2 of microtubule associated protein 1A (MAP1A)
    Sonja Wolff
    Department of Visceral and Transplantation Surgery at the Medical University of Ulm, Chirurgische Universitätsklinik Ulm, Steinhovelstr 9, 89075 Ulm, Germany
    Biochim Biophys Acta 1745:196-206. 2005
    ..Furthermore, LC2 has been identified as a new substrate of CK1delta. We therefore propose a model in which CK1delta could modulate microtubule dynamics by changing the phosphorylation status of the light chain LC2 of MAP1A...
  15. ncbi request reprint Inhibition of casein kinase I delta alters mitotic spindle formation and induces apoptosis in trophoblast cells
    Martin Stöter
    Department of Visceral and Transplantation Surgery, University of Ulm, Ulm, Germany
    Oncogene 24:7964-75. 2005
    ..Our findings indicate that CKIdelta plays an important role in the mitotic progression and in the survival of cells of trophoblast origin. Therefore, IC261 could provide a new tool in treating choriocarcinomas...
  16. doi request reprint Stages of granulovacuolar degeneration: their relation to Alzheimer's disease and chronic stress response
    Dietmar Rudolf Thal
    Laboratory of Neuropathology, Institute of Pathology, Center for Clinical Research, University of Ulm, Germany
    Acta Neuropathol 122:577-89. 2011
    ..Moreover, the association of the GVD stages with those of AD-related pathology but not with other neurodegenerative disorders points to a possible role of GVD and the response to chronic stress in the pathogenesis of AD...
  17. pmc Analysis of cell type-specific expression of CK1 epsilon in various tissues of young adult BALB/c Mice and in mammary tumors of SV40 T-Ag-transgenic mice
    Anja C Utz
    Department of General, Visceral, and Transplantation Surgery, University of Ulm, Steinhovelstr 9, 89075 Ulm, Germany
    J Histochem Cytochem 58:1-15. 2010
    ..This manuscript contains online supplemental material at http://www.jhc.org. Please visit this article online to view these materials...
  18. pmc Sepsis-Induced Adipokine Change with regard to Insulin Resistance
    Andreas Hillenbrand
    Department of General, Visceral, and Transplantation Surgery, University Hospital of Ulm, Steinhoevelstraße 9, 89075 Ulm, Germany
    Int J Inflam 2012:972368. 2012
    ..Changes in adipokine levels in acute sepsis could contribute to insulin resistance. Consequently, in critically ill patients, these alterations underline a possible contribution of adipokines in the development of hyperglycemia...
  19. ncbi request reprint Protein kinase CK1delta phosphorylates key sites in the acidic domain of murine double-minute clone 2 protein (MDM2) that regulate p53 turnover
    Markus Winter
    Institute for Toxicology and Genetics, Forschungszentrum Karlsruhe, PO Box 3640, 76021 Karlsruhe, Germany
    Biochemistry 43:16356-64. 2004
    ..These data establish the identity of a key signaling molecule that promotes the phosphorylation of a major regulatory region in MDM2 under normal growth conditions...
  20. ncbi request reprint Posttranslational modification of MDM2
    David W Meek
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
    Mol Cancer Res 1:1017-26. 2003
    ..In this review, we summarize our current knowledge of the role of posttranslational modifications of MDM2 and their functional relevance...