Research Topics
| J P KlussmannSummaryAffiliation: University of Cologne Country: Germany Publications
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Detail Information
Publications
Human herpesvirus type 8 in salivary gland tumorsJ P Klussmann
Department of Otorhinolaryngology, University of Cologne Medical School, D 50924, Cologne, Germany
J Clin Virol 16:239-46. 2000..Findings of HHV-8 DNA in saliva in some cases are suggestive of nonsexual transmission associated with latent infection of the salivary gland (as it is known for EBV, CMV, HHV-6 and HHV-7)...
Expression of p16 protein identifies a distinct entity of tonsillar carcinomas associated with human papillomavirusJens P Klussmann
Department of Oto Rhino Laryngology, Head, and Neck Surgery and the Institute of Virology, University of Cologne, Cologne, Germany
Am J Pathol 162:747-53. 2003..02). These data indicate that p16 is a technically simple immunohistological marker, applicable for routine pathological histology, and its prognostic value for survival is fully equivalent to HPV-DNA detection...- Human papillomavirus-positive tonsillar carcinomas: a different tumor entity?Jens P Klussmann
Department of Oto Rhino Laryngology, Head and Neck Surgery, University of Cologne, 50924 Cologne, Germany
Med Microbiol Immunol 192:129-32. 2003..Furthermore our results argue for HPV-positive tonsillar carcinomas representing a separate tumor entity, which is less dependent on conventional HNSCC risk factors... - [HPV-associated tonsillar cancer. An update]J P Klussmann
Klinik und Poliklinik für Hals Nasen Ohren Heilkunde des Klinikum der Universität zu Köln, Cologne
HNO 52:208-18. 2004..New insights and increasing evidence for the analogy of HPV-positive HNSCC with cervical cancer are discussed. The definition of HPV-positive HNSCC has become more important due to the implications for risk factors and prognosis... - Detection of HHV-8 sequences and antigens in a MALT lymphoma associated with Sjögren's syndromeJens Peter Klussmann
Department of Otorhinolaryngology, University of Cologne, D 50924 Cologne, Germany
J Oral Pathol Med 32:243-5. 2003..The potential influence of HHV-8 infection for MALT lymphoma development in this case and possible parallels to gastric MALT lymphoma are discussed... 
[Human papillomavirus and cancer of the oropharynx. Molecular interaction and clinical implications]J P Klussmann
Klinik und Poliklinik für Hals Nasen Ohren Heilkunde, Klinikum der Universität zu Köln, Kerpener Strasse 62, 50924, Koln
HNO 57:113-22. 2009..Therefore, we think it will be mandatory to consider and stratify HPV status in the design of prospective clinical trials in the future...- Prevalence, distribution, and viral load of human papillomavirus 16 DNA in tonsillar carcinomasJ P Klussmann
Department of Oto Rhino Laryngology, University of Cologne, Cologne, Germany
Cancer 92:2875-84. 2001..The authors determined the load and localization of HPV DNA in a subset of tonsillar carcinomas and their metastases... - Genetic signatures of HPV-related and unrelated oropharyngeal carcinoma and their prognostic implicationsJens P Klussmann
Department of Oto Rhino Laryngology, Head and Neck Surgery, Jean Uhrmacher Institute, University of Cologne, Cologne, Germany
Clin Cancer Res 15:1779-86. 2009..Patients with human papillomavirus (HPV)-containing oropharyngeal squamous cell carcinomas (OSCC) have a better prognosis than patients with HPV-negative OSCC. This may be attributed to different genetic pathways promoting cancer... - Atresia of the trachea following repeated percutaneous dilational tracheotomyJ P Klussmann
Department of Otorhinolaryngology, University of Cologne, Cologne, Germany
Chest 119:961-4. 2001..The dimension of the lesion is visualized by three-dimensional reconstructed CT scan. The etiology of this condition is discussed... - Nuclear survivin expression is associated with HPV-independent carcinogenesis and is an indicator of poor prognosis in oropharyngeal cancerS F Preuss
Department of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, University Hospital of Cologne, Cologne, Germany
Br J Cancer 98:627-32. 2008..975; 95% CI=2.377-107.360; P=0.004, respectively). Our data show that nuclear accumulation of survivin correlates with HPV-independent carcinogenesis and is an independent predictor of poor survival in patients with OSCC... - The impact of cidofovir treatment on viral loads in adult recurrent respiratory papillomatosisS Mikolajczak
Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Kerpener Str 62, 50924 Cologne, Germany
Eur Arch Otorhinolaryngol 269:2543-8. 2012..Cidofovir in combination with surgical debulking reduces the viral load in patients with RRP. Relapses of the symptoms cannot be avoided but might be delayed... - [Update on HPV-induced oropharyngeal cancer]S F Preuss
Klinik und Poliklinik für Hals Nasen Ohren Heilkunde, Kopf Hals Chirurgie, Klinikum der Universität zu Köln, Kerpener Str 62, 50924, Koln, Deutschland
HNO 59:1031-7; quiz 1038. 2011..If the results of these prospective, randomized trials are consistent with the preliminary results of recent studies, HPV status will be of enormous clinical relevance in the future... - Long-term results of the combined modality therapy for advanced cervical metastatic head and neck squamous cell carcinomaS F Preuss
Department of Otorhinolaryngology, Head and Neck Surgery, Medical School, University of Cologne, Josef Stelzmann Str 9, 50924 Cologne, Germany
Eur J Surg Oncol 33:358-63. 2007..The aim of this retrospective study was to investigate the outcome of these patients uniformely using a strategy which consists of surgery for the primary tumor and the neck metastases followed by postoperative radio(chemo)therapy... - Transoral laser surgery for laryngeal cancer: outcome, complications and prognostic factors in 275 patientsS F Preuss
Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Germany
Eur J Surg Oncol 35:235-40. 2009..The aim of this study was to review the experience of a single center institution with TLS for early and advanced laryngeal cancer... - Patterns of lymph node spread and its influence on outcome in resectable parotid cancerJ P Klussmann
Clinic of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, D 50924 Koln, Germany
Eur J Surg Oncol 34:932-7. 2008..To assess the metastatic topography of intraparotideal and neck lymph nodes in parotid cancer and its influence on tumour recurrence and survival... - Accessory parotid gland lesions: case report and review of literatureM Stenner
Department of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, University Hospital of Cologne, Kerpener Strasse 62, Cologne, Germany
Eur Arch Otorhinolaryngol 265:1135-8. 2008..Hereby, for the first time we report a case with multiple calculi in an accessory parotid gland removed via a standard parotid incision. Further to this, we give a comprehensive review of literature on accessory parotid gland lesions... - Cyclin-dependent kinase-inhibitor 1 (CDKN1A) in the squamous epithelium of the oropharynx: possible implications of molecular biology and compartmentationM Wagner
Department of Pathology, University of Cologne Medical School, Cologne, FRG
Anticancer Res 21:333-45. 2001..We found no correlation between nuclear and cytoplasmic anti-CDKN1A immunoreactivity in our samples of oropharyngeal squamous cell carcinoma. CDKN1A Cap20, CDKN1, CDKN1A, CDKNA1, Cip-1, Mda-6, P21, Pic1, Sdi-1, Waf-1... - [Cricohyoidopexy (CHP) and Cricohyoidoepiglottopexy (CHEP). Indication, complications, functional und oncological results]U Schroder
Universitäts Hals Nasen Ohren Klinik Köln, Cologne
HNO 51:38-45. 2003.... - [Vallecular cyst as a rare cause of progressive inspiratory stridor]D Beutner
Klinik und Poliklinik Fur Hals, Nasen und Ohrenkrankheiten der Universität zu Köln, 50924 Köln
Laryngorhinootologie 85:441-3. 2006..Usually they appear as harmless and asymptomatic and go unnoticed by the patient. In rare cases, obstructions of the upper airway due to monstrous vallecular cysts may become life threatening... - [Indolent neck tumour. A 47 year old patient with a painless tumour in the area of the left mandibular angle]S F Preuss
, Nasen, Ohrenheilkunde,
HNO 53:876-8. 2005 - [Olfactory dysfunctions. Epidemiology and therapy in Germany, Austria and Switzerland]M Damm
Hals Nasen Ohren Klinik, Universitat zu Koln, Koln
HNO 52:112-20. 2004..The aim of this survey was to obtain comparable epidemiological data and treatment information on olfactory dysfunction in German speaking countries... - Histopathology of pleomorphic adenoma in the parotid gland: a prospective unselected series of 100 casesE Stennert
Department of Otorhinolaryngology, University of Cologne, Koeln, Germany
Laryngoscope 111:2195-200. 2001.... - [Dysphagia as a presenting symptom of a cervical neurofibroma]J Vent
Klinik und Poliklinik für Hals Nasen Ohren Heilkunde, Kopf und Halschirurgie, Universitätsklinikum Köln, Koln, Germany
HNO 57:625-8. 2009..Management and differential diagnoses of globus sensation are herein discussed. This case underlines the importance of tomographic imaging, even in common but persisting symptoms such as globus sensation... - Long-term results of surgical treatment for recurrent respiratory papillomatosisSimon Florian Preuss
Department of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, University of Cologne, Josef Stelzmann Str 9, 50924 Cologne, Germany
Acta Otolaryngol 127:1196-201. 2007..A meticulous follow-up for early recognition of local recurrence and malignant transformation is recommended... - Results of a European survey on current controversies in otologySimon Florian Preuss
Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Cologne, Germany
Otol Neurotol 28:774-7. 2007..Various topics in otology cause controversy among otologists internationally. The resulting variety of diagnostic and surgical concepts reflects differences between surgical schools and the lack of structured studies in the field... - Complications of suspension laryngoscopyJens Peter Klussmann
Department of Otorhinolaryngology-Head and Neck Surgery, University of Cologne, Cologne, Germany
Ann Otol Rhinol Laryngol 111:972-6. 2002..Although minor complications frequently occur during SL, it is a relatively safe procedure with a low risk of significant morbidity... - Submandibular gland excision: 15 years of experienceSimon Florian Preuss
Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Cologne, Germany
J Oral Maxillofac Surg 65:953-7. 2007..The aim of this study was to review a single institution's experience of a nonselected case series of submandibular gland excision over 15 years... - An analysis of surgical complications, morbidity, and cost calculation in patients undergoing multimodal treatment for operable oropharyngeal carcinomaSimon F Preuss
Department of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, University of Cologne, Cologne, Germany
Laryngoscope 117:101-5. 2007..Furthermore, multimodal treatment protocols should be judged by their complication rates, morbidity, and therapy costs... - Management of bilateral arytenoid cartilage fixation versus recurrent laryngeal nerve paralysisHans Edmund Eckel
Department of Otorhinolaryngology, University of Cologne Medical School, Cologne, Germany
Ann Otol Rhinol Laryngol 112:103-8. 2003..Additional sites of stenosis were more frequent in ACF patients. Stenosis due to RLNP could be managed endoscopically without preliminary tracheotomy, while ACF frequently required open surgery and temporary tracheotomy... - Recurrent pleomorphic adenoma of the parotid gland: a prospective histopathological and immunohistochemical studyEberhard Stennert
Department of Otolaryngology-Head and Neck Surgery, University of Cologne, Koeln, Germany
Laryngoscope 114:158-63. 2004..Therefore, a total parotidectomy including removal of surrounding fat tissue seems to be appropriate for the initial treatment of recurrent pleomorphic adenoma... - Primary parotid malignoma surgery in patients with normal preoperative facial nerve function: outcome and long-term postoperative facial nerve functionOrlando Guntinas-Lichius
Clinic of Otorhinolaryngology Head and Neck Surgery, University of Cologne, Germany
Laryngoscope 114:949-56. 2004..The common surgical strategy for these patients is to perform a parotidectomy with facial nerve preservation. Nevertheless, the functional outcome for the facial nerve and oncological outcome is unclear... - Easy and safe dental protection in rigid endoscopyGero Quante
Clinic of Otolaryngology-Head and Neck Surgery, University of Cologne, Germany
Otolaryngol Head Neck Surg 132:247-8. 2005 - T cells specific for HPV16 E7 epitopes in patients with squamous cell carcinoma of the oropharynxThomas K Hoffmann
Department of Otorhinolaryngology, University of Duesseldorf, Germany
Int J Cancer 118:1984-91. 2006.... - A rare differential diagnosis in dysphagia: wound botulismSimon Florian Preuss
Department of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, University of Cologne, Cologne, Germany
Laryngoscope 116:831-2. 2006..Because patients presenting with dysarthria and dysphagia will often be seen by an ear, nose and throat specialist initially, this rare but upcoming neurologic disease must be considered in the differential diagnoses... - Outcome of multimodal treatment for oropharyngeal carcinoma: a single institution experienceSimon Florian Preuss
Department of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, University of Cologne, Cologne, Germany
Oral Oncol 43:402-7. 2007..To assess this multimodal treatment approach, morbidity and economic considerations need to be further analyzed... - High incidence of lymph node metastasis in major salivary gland cancerEberhard Stennert
Department of Oto-Rhino-Laryngology, Head and Neck Surgery, University of Cologne, Cologne, Germany
Arch Otolaryngol Head Neck Surg 129:720-3. 2003..Neck dissections should be considered as an integral part of the surgical approach in patients with major salivary gland cancer, especially if no postoperative radiation therapy is planned... - Suspension laryngoscopy for endotracheal stentingHans Edmund Eckel
Department of Otorhinolaryngology, Landeskrankenhaus Klagenfurt, Austria
Laryngoscope 113:11-5. 2003..The study seeks to determine the role of suspension laryngoscopy in interdisciplinary airway stenting... - New aspects in parotid gland surgeryEberhard Stennert
Clinic of Oto-Rhino-Laryngology, Head and Neck Surgery, University of Cologne, Germany
Otolaryngol Pol 58:109-14. 2004..Of the 139 patients with clinical N0 neck 45% had occult neck metastasis. In conclusion neck dissection should be considered as an integral part of the surgical concept in major salivary gland cancer patients...