J P Klussmann

Summary

Affiliation: University of Cologne
Country: Germany

Publications

  1. ncbi request reprint Human herpesvirus type 8 in salivary gland tumors
    J P Klussmann
    Department of Otorhinolaryngology, University of Cologne Medical School, D 50924, Cologne, Germany
    J Clin Virol 16:239-46. 2000
  2. pmc Expression of p16 protein identifies a distinct entity of tonsillar carcinomas associated with human papillomavirus
    Jens P Klussmann
    Department of Oto Rhino Laryngology, Head, and Neck Surgery and the Institute of Virology, University of Cologne, Cologne, Germany
    Am J Pathol 162:747-53. 2003
  3. ncbi request reprint Human papillomavirus-positive tonsillar carcinomas: a different tumor entity?
    Jens P Klussmann
    Department of Oto Rhino Laryngology, Head and Neck Surgery, University of Cologne, 50924 Cologne, Germany
    Med Microbiol Immunol 192:129-32. 2003
  4. ncbi request reprint [HPV-associated tonsillar cancer. An update]
    J P Klussmann
    Klinik und Poliklinik für Hals Nasen Ohren Heilkunde des Klinikum der Universität zu Köln, Cologne
    HNO 52:208-18. 2004
  5. ncbi request reprint Detection of HHV-8 sequences and antigens in a MALT lymphoma associated with Sjögren's syndrome
    Jens Peter Klussmann
    Department of Otorhinolaryngology, University of Cologne, D 50924 Cologne, Germany
    J Oral Pathol Med 32:243-5. 2003
  6. doi request reprint [Human papillomavirus and cancer of the oropharynx. Molecular interaction and clinical implications]
    J P Klussmann
    Klinik und Poliklinik für Hals Nasen Ohren Heilkunde, Klinikum der Universität zu Köln, Kerpener Strasse 62, 50924, Koln
    HNO 57:113-22. 2009
  7. ncbi request reprint Prevalence, distribution, and viral load of human papillomavirus 16 DNA in tonsillar carcinomas
    J P Klussmann
    Department of Oto Rhino Laryngology, University of Cologne, Cologne, Germany
    Cancer 92:2875-84. 2001
  8. doi request reprint Genetic signatures of HPV-related and unrelated oropharyngeal carcinoma and their prognostic implications
    Jens P Klussmann
    Department of Oto Rhino Laryngology, Head and Neck Surgery, Jean Uhrmacher Institute, University of Cologne, Cologne, Germany
    Clin Cancer Res 15:1779-86. 2009
  9. ncbi request reprint Atresia of the trachea following repeated percutaneous dilational tracheotomy
    J P Klussmann
    Department of Otorhinolaryngology, University of Cologne, Cologne, Germany
    Chest 119:961-4. 2001
  10. pmc Nuclear survivin expression is associated with HPV-independent carcinogenesis and is an indicator of poor prognosis in oropharyngeal cancer
    S F Preuss
    Department of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, University Hospital of Cologne, Cologne, Germany
    Br J Cancer 98:627-32. 2008

Detail Information

Publications38

  1. ncbi request reprint Human herpesvirus type 8 in salivary gland tumors
    J P Klussmann
    Department of Otorhinolaryngology, University of Cologne Medical School, D 50924, Cologne, Germany
    J Clin Virol 16:239-46. 2000
    ..Findings of HHV-8 DNA in saliva in some cases are suggestive of nonsexual transmission associated with latent infection of the salivary gland (as it is known for EBV, CMV, HHV-6 and HHV-7)...
  2. pmc Expression of p16 protein identifies a distinct entity of tonsillar carcinomas associated with human papillomavirus
    Jens P Klussmann
    Department of Oto Rhino Laryngology, Head, and Neck Surgery and the Institute of Virology, University of Cologne, Cologne, Germany
    Am J Pathol 162:747-53. 2003
    ..02). These data indicate that p16 is a technically simple immunohistological marker, applicable for routine pathological histology, and its prognostic value for survival is fully equivalent to HPV-DNA detection...
  3. ncbi request reprint Human papillomavirus-positive tonsillar carcinomas: a different tumor entity?
    Jens P Klussmann
    Department of Oto Rhino Laryngology, Head and Neck Surgery, University of Cologne, 50924 Cologne, Germany
    Med Microbiol Immunol 192:129-32. 2003
    ..Furthermore our results argue for HPV-positive tonsillar carcinomas representing a separate tumor entity, which is less dependent on conventional HNSCC risk factors...
  4. ncbi request reprint [HPV-associated tonsillar cancer. An update]
    J P Klussmann
    Klinik und Poliklinik für Hals Nasen Ohren Heilkunde des Klinikum der Universität zu Köln, Cologne
    HNO 52:208-18. 2004
    ..New insights and increasing evidence for the analogy of HPV-positive HNSCC with cervical cancer are discussed. The definition of HPV-positive HNSCC has become more important due to the implications for risk factors and prognosis...
  5. ncbi request reprint Detection of HHV-8 sequences and antigens in a MALT lymphoma associated with Sjögren's syndrome
    Jens Peter Klussmann
    Department of Otorhinolaryngology, University of Cologne, D 50924 Cologne, Germany
    J Oral Pathol Med 32:243-5. 2003
    ..The potential influence of HHV-8 infection for MALT lymphoma development in this case and possible parallels to gastric MALT lymphoma are discussed...
  6. doi request reprint [Human papillomavirus and cancer of the oropharynx. Molecular interaction and clinical implications]
    J P Klussmann
    Klinik und Poliklinik für Hals Nasen Ohren Heilkunde, Klinikum der Universität zu Köln, Kerpener Strasse 62, 50924, Koln
    HNO 57:113-22. 2009
    ..Therefore, we think it will be mandatory to consider and stratify HPV status in the design of prospective clinical trials in the future...
  7. ncbi request reprint Prevalence, distribution, and viral load of human papillomavirus 16 DNA in tonsillar carcinomas
    J P Klussmann
    Department of Oto Rhino Laryngology, University of Cologne, Cologne, Germany
    Cancer 92:2875-84. 2001
    ..The authors determined the load and localization of HPV DNA in a subset of tonsillar carcinomas and their metastases...
  8. doi request reprint Genetic signatures of HPV-related and unrelated oropharyngeal carcinoma and their prognostic implications
    Jens P Klussmann
    Department of Oto Rhino Laryngology, Head and Neck Surgery, Jean Uhrmacher Institute, University of Cologne, Cologne, Germany
    Clin Cancer Res 15:1779-86. 2009
    ..Patients with human papillomavirus (HPV)-containing oropharyngeal squamous cell carcinomas (OSCC) have a better prognosis than patients with HPV-negative OSCC. This may be attributed to different genetic pathways promoting cancer...
  9. ncbi request reprint Atresia of the trachea following repeated percutaneous dilational tracheotomy
    J P Klussmann
    Department of Otorhinolaryngology, University of Cologne, Cologne, Germany
    Chest 119:961-4. 2001
    ..The dimension of the lesion is visualized by three-dimensional reconstructed CT scan. The etiology of this condition is discussed...
  10. pmc Nuclear survivin expression is associated with HPV-independent carcinogenesis and is an indicator of poor prognosis in oropharyngeal cancer
    S F Preuss
    Department of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, University Hospital of Cologne, Cologne, Germany
    Br J Cancer 98:627-32. 2008
    ..975; 95% CI=2.377-107.360; P=0.004, respectively). Our data show that nuclear accumulation of survivin correlates with HPV-independent carcinogenesis and is an independent predictor of poor survival in patients with OSCC...
  11. doi request reprint The impact of cidofovir treatment on viral loads in adult recurrent respiratory papillomatosis
    S Mikolajczak
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Kerpener Str 62, 50924 Cologne, Germany
    Eur Arch Otorhinolaryngol 269:2543-8. 2012
    ..Cidofovir in combination with surgical debulking reduces the viral load in patients with RRP. Relapses of the symptoms cannot be avoided but might be delayed...
  12. doi request reprint [Update on HPV-induced oropharyngeal cancer]
    S F Preuss
    Klinik und Poliklinik für Hals Nasen Ohren Heilkunde, Kopf Hals Chirurgie, Klinikum der Universität zu Köln, Kerpener Str 62, 50924, Koln, Deutschland
    HNO 59:1031-7; quiz 1038. 2011
    ..If the results of these prospective, randomized trials are consistent with the preliminary results of recent studies, HPV status will be of enormous clinical relevance in the future...
  13. ncbi request reprint Long-term results of the combined modality therapy for advanced cervical metastatic head and neck squamous cell carcinoma
    S F Preuss
    Department of Otorhinolaryngology, Head and Neck Surgery, Medical School, University of Cologne, Josef Stelzmann Str 9, 50924 Cologne, Germany
    Eur J Surg Oncol 33:358-63. 2007
    ..The aim of this retrospective study was to investigate the outcome of these patients uniformely using a strategy which consists of surgery for the primary tumor and the neck metastases followed by postoperative radio(chemo)therapy...
  14. doi request reprint Transoral laser surgery for laryngeal cancer: outcome, complications and prognostic factors in 275 patients
    S F Preuss
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Germany
    Eur J Surg Oncol 35:235-40. 2009
    ..The aim of this study was to review the experience of a single center institution with TLS for early and advanced laryngeal cancer...
  15. doi request reprint Patterns of lymph node spread and its influence on outcome in resectable parotid cancer
    J P Klussmann
    Clinic of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, D 50924 Koln, Germany
    Eur J Surg Oncol 34:932-7. 2008
    ..To assess the metastatic topography of intraparotideal and neck lymph nodes in parotid cancer and its influence on tumour recurrence and survival...
  16. doi request reprint Accessory parotid gland lesions: case report and review of literature
    M Stenner
    Department of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, University Hospital of Cologne, Kerpener Strasse 62, Cologne, Germany
    Eur Arch Otorhinolaryngol 265:1135-8. 2008
    ..Hereby, for the first time we report a case with multiple calculi in an accessory parotid gland removed via a standard parotid incision. Further to this, we give a comprehensive review of literature on accessory parotid gland lesions...
  17. ncbi request reprint Cyclin-dependent kinase-inhibitor 1 (CDKN1A) in the squamous epithelium of the oropharynx: possible implications of molecular biology and compartmentation
    M Wagner
    Department of Pathology, University of Cologne Medical School, Cologne, FRG
    Anticancer Res 21:333-45. 2001
    ..We found no correlation between nuclear and cytoplasmic anti-CDKN1A immunoreactivity in our samples of oropharyngeal squamous cell carcinoma. CDKN1A Cap20, CDKN1, CDKN1A, CDKNA1, Cip-1, Mda-6, P21, Pic1, Sdi-1, Waf-1...
  18. ncbi request reprint [Cricohyoidopexy (CHP) and Cricohyoidoepiglottopexy (CHEP). Indication, complications, functional und oncological results]
    U Schroder
    Universitäts Hals Nasen Ohren Klinik Köln, Cologne
    HNO 51:38-45. 2003
    ....
  19. ncbi request reprint [Vallecular cyst as a rare cause of progressive inspiratory stridor]
    D Beutner
    Klinik und Poliklinik Fur Hals, Nasen und Ohrenkrankheiten der Universität zu Köln, 50924 Köln
    Laryngorhinootologie 85:441-3. 2006
    ..Usually they appear as harmless and asymptomatic and go unnoticed by the patient. In rare cases, obstructions of the upper airway due to monstrous vallecular cysts may become life threatening...
  20. ncbi request reprint [Indolent neck tumour. A 47 year old patient with a painless tumour in the area of the left mandibular angle]
    S F Preuss
    Klinik und Poliklinik Fur Hals, Nasen, Ohrenheilkunde, Universitat zu Koln
    HNO 53:876-8. 2005
  21. ncbi request reprint [Olfactory dysfunctions. Epidemiology and therapy in Germany, Austria and Switzerland]
    M Damm
    Hals Nasen Ohren Klinik, Universitat zu Koln, Koln
    HNO 52:112-20. 2004
    ..The aim of this survey was to obtain comparable epidemiological data and treatment information on olfactory dysfunction in German speaking countries...
  22. ncbi request reprint Histopathology of pleomorphic adenoma in the parotid gland: a prospective unselected series of 100 cases
    E Stennert
    Department of Otorhinolaryngology, University of Cologne, Koeln, Germany
    Laryngoscope 111:2195-200. 2001
    ....
  23. doi request reprint [Dysphagia as a presenting symptom of a cervical neurofibroma]
    J Vent
    Klinik und Poliklinik für Hals Nasen Ohren Heilkunde, Kopf und Halschirurgie, Universitätsklinikum Köln, Koln, Germany
    HNO 57:625-8. 2009
    ..Management and differential diagnoses of globus sensation are herein discussed. This case underlines the importance of tomographic imaging, even in common but persisting symptoms such as globus sensation...
  24. ncbi request reprint Long-term results of surgical treatment for recurrent respiratory papillomatosis
    Simon Florian Preuss
    Department of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, University of Cologne, Josef Stelzmann Str 9, 50924 Cologne, Germany
    Acta Otolaryngol 127:1196-201. 2007
    ..A meticulous follow-up for early recognition of local recurrence and malignant transformation is recommended...
  25. ncbi request reprint Results of a European survey on current controversies in otology
    Simon Florian Preuss
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Cologne, Germany
    Otol Neurotol 28:774-7. 2007
    ..Various topics in otology cause controversy among otologists internationally. The resulting variety of diagnostic and surgical concepts reflects differences between surgical schools and the lack of structured studies in the field...
  26. ncbi request reprint Complications of suspension laryngoscopy
    Jens Peter Klussmann
    Department of Otorhinolaryngology Head and Neck Surgery, University of Cologne, Cologne, Germany
    Ann Otol Rhinol Laryngol 111:972-6. 2002
    ..Although minor complications frequently occur during SL, it is a relatively safe procedure with a low risk of significant morbidity...
  27. ncbi request reprint Submandibular gland excision: 15 years of experience
    Simon Florian Preuss
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Cologne, Germany
    J Oral Maxillofac Surg 65:953-7. 2007
    ..The aim of this study was to review a single institution's experience of a nonselected case series of submandibular gland excision over 15 years...
  28. ncbi request reprint An analysis of surgical complications, morbidity, and cost calculation in patients undergoing multimodal treatment for operable oropharyngeal carcinoma
    Simon F Preuss
    Department of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, University of Cologne, Cologne, Germany
    Laryngoscope 117:101-5. 2007
    ..Furthermore, multimodal treatment protocols should be judged by their complication rates, morbidity, and therapy costs...
  29. ncbi request reprint Management of bilateral arytenoid cartilage fixation versus recurrent laryngeal nerve paralysis
    Hans Edmund Eckel
    Department of Otorhinolaryngology, University of Cologne Medical School, Cologne, Germany
    Ann Otol Rhinol Laryngol 112:103-8. 2003
    ..Additional sites of stenosis were more frequent in ACF patients. Stenosis due to RLNP could be managed endoscopically without preliminary tracheotomy, while ACF frequently required open surgery and temporary tracheotomy...
  30. ncbi request reprint Recurrent pleomorphic adenoma of the parotid gland: a prospective histopathological and immunohistochemical study
    Eberhard Stennert
    Department of Otolaryngology Head and Neck Surgery, University of Cologne, Koeln, Germany
    Laryngoscope 114:158-63. 2004
    ..Histopathological characteristics and proliferation indices of recurrent pleomorphic adenoma were described in a series of 31 patients who were referred to the authors' clinic for revision surgery...
  31. ncbi request reprint Primary parotid malignoma surgery in patients with normal preoperative facial nerve function: outcome and long-term postoperative facial nerve function
    Orlando Guntinas-Lichius
    Clinic of Otorhinolaryngology Head and Neck Surgery, University of Cologne, Germany
    Laryngoscope 114:949-56. 2004
    ..The common surgical strategy for these patients is to perform a parotidectomy with facial nerve preservation. Nevertheless, the functional outcome for the facial nerve and oncological outcome is unclear...
  32. ncbi request reprint Easy and safe dental protection in rigid endoscopy
    Gero Quante
    Clinic of Otolaryngology Head and Neck Surgery, University of Cologne, Germany
    Otolaryngol Head Neck Surg 132:247-8. 2005
  33. ncbi request reprint T cells specific for HPV16 E7 epitopes in patients with squamous cell carcinoma of the oropharynx
    Thomas K Hoffmann
    Department of Otorhinolaryngology, University of Duesseldorf, Germany
    Int J Cancer 118:1984-91. 2006
    ....
  34. ncbi request reprint A rare differential diagnosis in dysphagia: wound botulism
    Simon Florian Preuss
    Department of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, University of Cologne, Cologne, Germany
    Laryngoscope 116:831-2. 2006
    ..Because patients presenting with dysarthria and dysphagia will often be seen by an ear, nose and throat specialist initially, this rare but upcoming neurologic disease must be considered in the differential diagnoses...
  35. ncbi request reprint Outcome of multimodal treatment for oropharyngeal carcinoma: a single institution experience
    Simon Florian Preuss
    Department of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, University of Cologne, Cologne, Germany
    Oral Oncol 43:402-7. 2007
    ..To assess this multimodal treatment approach, morbidity and economic considerations need to be further analyzed...
  36. ncbi request reprint High incidence of lymph node metastasis in major salivary gland cancer
    Eberhard Stennert
    Department of Oto Rhino Laryngology, Head and Neck Surgery, University of Cologne, Cologne, Germany
    Arch Otolaryngol Head Neck Surg 129:720-3. 2003
    ..To analyze the incidence and risk factors for clinically apparent and occult lymph node metastases in patients with major salivary gland cancers...
  37. ncbi request reprint Suspension laryngoscopy for endotracheal stenting
    Hans Edmund Eckel
    Department of Otorhinolaryngology, Landeskrankenhaus Klagenfurt, Austria
    Laryngoscope 113:11-5. 2003
    ..The study seeks to determine the role of suspension laryngoscopy in interdisciplinary airway stenting...
  38. ncbi request reprint New aspects in parotid gland surgery
    Eberhard Stennert
    Clinic of Oto Rhino Laryngology, Head and Neck Surgery, University of Cologne, Germany
    Otolaryngol Pol 58:109-14. 2004
    ..Of the 139 patients with clinical N0 neck 45% had occult neck metastasis. In conclusion neck dissection should be considered as an integral part of the surgical concept in major salivary gland cancer patients...