Michael Kluge

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. pmc Methylphenidate in mania project (MEMAP): study protocol of an international randomised double-blind placebo-controlled study on the initial treatment of acute mania with methylphenidate
    Michael Kluge
    Department of Psychiatry and Psychotherapy, University of Leipzig, Semmelweisstrasse 10, 04103, Leipzig, Germany
    BMC Psychiatry 13:71. 2013
  2. doi request reprint Olanzapine and clozapine differently affect sleep in patients with schizophrenia: results from a double-blind, polysomnographic study and review of the literature
    Michael Kluge
    Department of Psychiatry, University of Leipzig, Leipzig, Germany Max Planck Institute of Psychiatry, Munich, Germany Electronic address
    Schizophr Res 152:255-60. 2014
  3. doi request reprint Ghrelin suppresses nocturnal secretion of luteinizing hormone (LH) and thyroid stimulating hormone (TSH) in patients with major depression
    Michael Kluge
    Max Planck Institute of Psychiatry, Munich, Germany
    J Psychiatr Res 47:1236-9. 2013
  4. doi request reprint Sleep propensity at daytime as assessed by Multiple Sleep Latency Tests (MSLT) in patients with schizophrenia increases with clozapine and olanzapine
    Michael Kluge
    Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany
    Schizophr Res 135:123-7. 2012
  5. doi request reprint Ghrelin suppresses secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in women
    Michael Kluge
    Max Planck Institute of Psychiatry, Munich, Germany
    J Clin Endocrinol Metab 97:E448-51. 2012
  6. doi request reprint Ghrelin affects the hypothalamus-pituitary-thyroid axis in humans by increasing free thyroxine and decreasing TSH in plasma
    Michael Kluge
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, Munich, Germany
    Eur J Endocrinol 162:1059-65. 2010
  7. doi request reprint Effects of ghrelin on psychopathology, sleep and secretion of cortisol and growth hormone in patients with major depression
    Michael Kluge
    Max Planck Institute of Psychiatry, Munich, Germany
    J Psychiatr Res 45:421-6. 2011
  8. doi request reprint Ghrelin increases slow wave sleep and stage 2 sleep and decreases stage 1 sleep and REM sleep in elderly men but does not affect sleep in elderly women
    Michael Kluge
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Psychoneuroendocrinology 35:297-304. 2010
  9. doi request reprint Effects of clozapine and olanzapine on cytokine systems are closely linked to weight gain and drug-induced fever
    Michael Kluge
    Max Planck Institute of Psychiatry, Munich, Germany
    Psychoneuroendocrinology 34:118-28. 2009
  10. doi request reprint Ghrelin alone or co-administered with GHRH or CRH increases non-REM sleep and decreases REM sleep in young males
    Michael Kluge
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Psychoneuroendocrinology 33:497-506. 2008

Detail Information

Publications31

  1. pmc Methylphenidate in mania project (MEMAP): study protocol of an international randomised double-blind placebo-controlled study on the initial treatment of acute mania with methylphenidate
    Michael Kluge
    Department of Psychiatry and Psychotherapy, University of Leipzig, Semmelweisstrasse 10, 04103, Leipzig, Germany
    BMC Psychiatry 13:71. 2013
    ..We present here the study protocol of a trial intended to study the efficacy and safety of methylphenidate in the initial treatment of acute mania...
  2. doi request reprint Olanzapine and clozapine differently affect sleep in patients with schizophrenia: results from a double-blind, polysomnographic study and review of the literature
    Michael Kluge
    Department of Psychiatry, University of Leipzig, Leipzig, Germany Max Planck Institute of Psychiatry, Munich, Germany Electronic address
    Schizophr Res 152:255-60. 2014
    ..e. met the diagnosis of an RLS. In conclusion, sleep continuity similarly improved and sleep architecture changed more physiologically with olanzapine. Neither of the antipsychotics induced RLS symptoms that were clinically relevant...
  3. doi request reprint Ghrelin suppresses nocturnal secretion of luteinizing hormone (LH) and thyroid stimulating hormone (TSH) in patients with major depression
    Michael Kluge
    Max Planck Institute of Psychiatry, Munich, Germany
    J Psychiatr Res 47:1236-9. 2013
    ..In conclusion, ghrelin suppressed nocturnal secretion of LH and TSH in patients with major depression. However, these effects were weaker than previously shown in healthy subjects. ..
  4. doi request reprint Sleep propensity at daytime as assessed by Multiple Sleep Latency Tests (MSLT) in patients with schizophrenia increases with clozapine and olanzapine
    Michael Kluge
    Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig, Germany
    Schizophr Res 135:123-7. 2012
    ..Furthermore, clozapine and olanzapine increased sleep propensity in schizophrenic patients. A minority of patients reported subjective sleepiness...
  5. doi request reprint Ghrelin suppresses secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in women
    Michael Kluge
    Max Planck Institute of Psychiatry, Munich, Germany
    J Clin Endocrinol Metab 97:E448-51. 2012
    ..Ghrelin has been shown to suppress secretion of LH and, less regularly, of FSH in male and female animals and human males. However, no such evidence exists for human females...
  6. doi request reprint Ghrelin affects the hypothalamus-pituitary-thyroid axis in humans by increasing free thyroxine and decreasing TSH in plasma
    Michael Kluge
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, Munich, Germany
    Eur J Endocrinol 162:1059-65. 2010
    ..g. by increasing energy expenditure. We therefore hypothesized that ghrelin suppresses the HPT axis in humans, counteracting its energy-saving effect...
  7. doi request reprint Effects of ghrelin on psychopathology, sleep and secretion of cortisol and growth hormone in patients with major depression
    Michael Kluge
    Max Planck Institute of Psychiatry, Munich, Germany
    J Psychiatr Res 45:421-6. 2011
    ..Ghrelin strongly affected sleep and secretion of GH and cortisol in a partly different way as previously reported in healthy subjects...
  8. doi request reprint Ghrelin increases slow wave sleep and stage 2 sleep and decreases stage 1 sleep and REM sleep in elderly men but does not affect sleep in elderly women
    Michael Kluge
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Psychoneuroendocrinology 35:297-304. 2010
    ..In both sexes, ghrelin caused comparable increases and secretion patterns of GH and cortisol. In conclusion, ghrelin affects sleep in elderly men but not women resembling findings in young subjects...
  9. doi request reprint Effects of clozapine and olanzapine on cytokine systems are closely linked to weight gain and drug-induced fever
    Michael Kluge
    Max Planck Institute of Psychiatry, Munich, Germany
    Psychoneuroendocrinology 34:118-28. 2009
    ..In conclusion, increase of BMI appears to be related to clozapine's and olanzapine's similar effects on cytokine systems, whilst drug-induced fever appears to be related to clozapine's differential effects on interleukin-6...
  10. doi request reprint Ghrelin alone or co-administered with GHRH or CRH increases non-REM sleep and decreases REM sleep in young males
    Michael Kluge
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Psychoneuroendocrinology 33:497-506. 2008
    ..CRH had sleep-improving and REM permissive effects when co-administered with ghrelin, being in contrast to the effect of CRH alone in previous studies...
  11. ncbi request reprint Clozapine and olanzapine are associated with food craving and binge eating: results from a randomized double-blind study
    Michael Kluge
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, Munich, Germany
    J Clin Psychopharmacol 27:662-6. 2007
    ..These results suggest that both clozapine and olanzapine can induce food craving and binge eating, however, olanzapine possibly to a greater extent. Findings on clinical efficacy and safety are in accordance with previous reports...
  12. ncbi request reprint Ghrelin administered in the early morning increases secretion of cortisol and growth hormone without affecting sleep
    Michael Kluge
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Psychoneuroendocrinology 32:287-92. 2007
    ..Sleep variables did not differ in both conditions. In contrast to GHRH, ghrelin's stimulatory effects were apparently not counteracted (GH), and enhanced (cortisol), respectively, by high CRH in the second half of night...
  13. doi request reprint Impaired off-line memory consolidation in depression
    Martin Dresler
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    Eur Neuropsychopharmacol 20:553-61. 2010
    ..This impairment seems to recover after remission from depression...
  14. doi request reprint Sleep and active renin levels--interaction with age, gender, growth hormone and cortisol
    Petra Schussler
    Max Planck Institute of Psychiatry, Munich, Germany schuessler mpipsykl mpg de
    Neuropsychobiology 61:113-21. 2010
    ..Furthermore, there are no data on the effects of age and gender on nocturnal renin and the interaction between these variables, sleep, growth hormone (GH) and cortisol...
  15. ncbi request reprint Ghrelin enhances the nocturnal secretion of cortisol and growth hormone in young females without influencing sleep
    Michael Kluge
    Max Planck Institute of Psychiatry, Munich, Germany
    Psychoneuroendocrinology 32:1079-85. 2007
    ..In contrast to findings in young men, ghrelin did not affect sleep in young women, indicating a sexual dimorphism. In accordance with the findings in young men, ghrelin stimulated secretion of GH and cortisol...
  16. doi request reprint A double dissociation of memory impairments in major depression
    Martin Dresler
    Endocrinology of Sleep, Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    J Psychiatr Res 45:1593-9. 2011
    ..The same tasks in the wake state show a reversed pattern, with performance in declarative but not nondeclarative tasks being impaired in major depression...
  17. ncbi request reprint Ghrelin suppresses secretion of luteinizing hormone in humans
    Michael Kluge
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    J Clin Endocrinol Metab 92:3202-5. 2007
    ..Ghrelin affects the hypothalamic-pituitary-gonadal axis in various nonhuman mammalians, predominantly by suppressing secretion of LH. However, for humans, no such evidence exists...
  18. ncbi request reprint Sleep onset REM periods in obsessive compulsive disorder
    Michael Kluge
    Max Planck Institute of Psychiatry, Munich, Germany
    Psychiatry Res 152:29-35. 2007
    ..05) more severe in these patients (Y-BOCS: 32+/-2.0) compared to those without SOREMPs (Y-BOCS 26+/-4.2). This is, to our knowledge, the first report of sleep onset REM periods in OCD...
  19. doi request reprint Ghrelin plasma levels are not altered in major depression
    Michael Kluge
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychobiology 59:199-204. 2009
    ..In addition, ghrelin levels in depressed patients decrease with psychopathological improvement. Therefore, we hypothesized that ghrelin levels in patients with major depression would be higher than in healthy subjects...
  20. ncbi request reprint Increased nocturnal secretion of ACTH and cortisol in obsessive compulsive disorder
    Michael Kluge
    Max Planck Institute of Psychiatry, Munich, Kraepelinstrasse 2 10, 80804 Munich, Germany
    J Psychiatr Res 41:928-33. 2007
    ..4; cortisol: 2148.4 +/-271.7) than in controls (ACTH: 460.2 +/- 61.0; cortisol: 1191.2 +/- 124.1). In conclusion, our findings suggest that the activity of the HPA axis in patients with OCD is increased compared to healthy controls...
  21. ncbi request reprint Duloxetine increases stage 3 sleep and suppresses rapid eye movement (REM) sleep in patients with major depression
    Michael Kluge
    Max Planck Institute of Psychiatry, Munich, Germany
    Eur Neuropsychopharmacol 17:527-31. 2007
    ..005) increased from 58.5+/-31.1 to 193.6+/-72.6 min. REM sleep significantly (P<0.005) decreased from 94.8+/-34.5 to 51.5+/-42.5 min. These results partly differ from those in healthy subjects receiving duloxetine...
  22. doi request reprint Ghrelin in mental health, sleep, memory
    Axel Steiger
    Max Planck Institute of Psychiatry, Munich, Germany
    Mol Cell Endocrinol 340:88-96. 2011
    ..Furthermore ghrelin appears to be related to memory and to be involved in the pathophysiology of CNS disorders, particularly depression...
  23. doi request reprint Sex and modulatory menstrual cycle effects on sleep related memory consolidation
    Lisa Genzel
    Max Planck Institute of Psychiatry, Kreapelinstr 2 10, 80804 Munich, Germany
    Psychoneuroendocrinology 37:987-98. 2012
    ..Further, contrary to previous reports, consolidation of a simple motor task can be induced by a 45 min NREM sleep nap, thus not dependent on REM sleep...
  24. doi request reprint Ghrelin levels increase after pictures showing food
    Petra Schussler
    Max Planck Institute of Psychiatry, Munich, Germany
    Obesity (Silver Spring) 20:1212-7. 2012
    ..158 %, P < 0.05). The difference in the increases between the two picture conditions was also significant (P < 0.05). Our findings suggest that sight of food elevates ghrelin levels in healthy volunteers...
  25. doi request reprint Ghrelin suppresses secretion of FSH in males
    Michael Kluge
    Max Planck Institute of Psychiatry, Munich, Germany
    Clin Endocrinol (Oxf) 70:920-3. 2009
    ..Ghrelin decreases the secretion of LH probably by suppressing the release of hypothalamic GnRH. So far however, there is no evidence that ghrelin affects also the secretion of FSH in humans, the other gonadotrophin regulated by GnRH...
  26. ncbi request reprint The influence of cytokines on wakefulness regulation: clinical relevance, mechanisms and methodological problems
    Julia Weschenfelder
    University of Leipzig, Department of Psychiatry, Semmelweisstrasse 10, 04103 Leipzig, Germany
    Psychiatr Danub 24:112-26. 2012
    ..Clinical studies of the influence of cytokines on wakefulness regulation are underrepresented in the research literature and objective measures of wakefulness such as the Multiple Sleep Latency Test (MSLT) are seldom reported...
  27. doi request reprint Off-line memory consolidation impairments in multiple sclerosis patients receiving high-dose corticosteroid treatment mirror consolidation impairments in depression
    Martin Dresler
    Max Planck Institute of Psychiatry, Munich, Germany
    Psychoneuroendocrinology 35:1194-202. 2010
    ..We tested if high-dose administration of corticosteroids impairs off-line motor memory consolidation in patients with multiple sclerosis (MS)...
  28. ncbi request reprint Altered nocturnal growth hormone (GH) secretion in obsessive compulsive disorder
    Michael Kluge
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Psychoneuroendocrinology 31:1098-104. 2006
    ..In conclusion, our results indicate that the nocturnal GH secretion in patients with OCD is altered compared to controls...
  29. ncbi request reprint Persistent generalized anxiety after brief exposure to the dopamine antagonist metoclopramide
    Michael Kluge
    Max Planck Institute of Psychiatry, Munich, Germany
    Psychiatry Clin Neurosci 61:193-5. 2007
    ..The case might provide an initial piece of evidence that dopaminergic neurotransmission can be involved in the pathogenesis of generalized anxiety disorder...
  30. pmc Frequency and relevance of psychoeducation in psychiatric diagnoses: results of two surveys five years apart in German-speaking European countries
    Christine Rummel-Kluge
    Klinik und Poliklinik für Psychiatrie und Psychotherapie am Klinikum rechts der Isar der Technischen Universität München, Munich, Germany
    BMC Psychiatry 13:170. 2013
    ..Studies investigating for which psychiatric diagnoses psychoeducation is offered and assessing its perceived relevance compared to other interventions are lacking...
  31. pmc Effectiveness and medication acceptance of olanzapine disintegrating tablets compared to standard olanzapine tablets in acutely treated psychiatric patients
    Jörg Czekalla
    Department of Psychiatry and Psychotherapy, RWTH Aachen University, Germany
    Patient Prefer Adherence 1:19-27. 2007
    ..This study compared effectiveness and acceptance of orally disintegrating olanzapine tablets (ODT) with standard-coated tablets (SOT) in acutely ill psychiatric patients admitted to psychiatric hospitals for emergency treatment...