Research Topics
| Joachim KlosterkotterSummaryAffiliation: University of Cologne Country: Germany Publications
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Detail Information
Publications
Indicated prevention of schizophreniaJoachim Klosterkotter
Klinik fur Psychiatrie und Psychotherapie, Universitat zu Koln, Kerpener Strasse 62, Koln, Germany
Dtsch Arztebl Int 105:532-9. 2008..For this reason, centers for the early recognition of schizophrenic disorders have come into existence worldwide. In these centers, much effort is devoted to the development and testing of suitable preventive strategies...
[What is the effect of trauma in post traumatic stress disorder?]J Klosterkotter
Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Universitat zu Koln
Fortschr Neurol Psychiatr 73:375-6. 2005
Kraepelin and psychotic prodromal conditionsJoachim Klosterkotter
Dept of Psychiatry and Psychotherapy, University of Cologne, 50924, Cologne, Germany
Eur Arch Psychiatry Clin Neurosci 258:74-84. 2008..This review will outline the current state of the art of a phase specific early detection and intervention based on these syndromes...- [For: "Every person with schizophrenia should be treated as early as possible"]Joachim Klosterkotter
Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Universitat zu Koln
Psychiatr Prax 33:105-6. 2006 - Binocular depth inversion as a paradigm of reduced visual information processing in prodromal state, antipsychotic-naïve and treated schizophreniaDagmar Koethe
Dept of Psychiatry and Psychotherapy, University of Cologne, Kerpener Str 62, 50924, Cologne, Germany
Eur Arch Psychiatry Clin Neurosci 259:195-202. 2009..70. Thus, the BDII may be useful as an additional neuropsychological test for assessment of patients at high risk for developing schizophrenia... - Early detection of psychosis - establishing a service for persons at riskFrauke Schultze-Lutter
University of Cologne, Department of Psychiatry and Psychotherapy, 50924 Cologne, Germany
Eur Psychiatry 24:1-10. 2009..The establishment phase of an early detection centre for prodromal psychosis is introduced and characterised, along with its detaining and promoting factors within a universal multi-payer health care system... - Neurocognitive indicators for a conversion to psychosis: comparison of patients in a potentially initial prodromal state who did or did not convert to a psychosisRalf Pukrop
Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Str 62, D 50937 Cologne, Germany
Schizophr Res 92:116-25. 2007.... - Successful deep brain stimulation of the nucleus accumbens in severe alcohol dependence is associated with changed performance monitoringJens Kuhn
Department of Psychiatry and Psychotherapy, University of Cologne, Germany
Addict Biol 16:620-3. 2011..Thus, this case supports the hypothesis that DBS of the NAc could have a positive effect on addiction trough a normalization of craving associated with aMCC dysfunction... - Neurocognitive functioning in subjects at risk for a first episode of psychosis compared with first- and multiple-episode schizophreniaRalf Pukrop
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
J Clin Exp Neuropsychol 28:1388-407. 2006..Results support a neurodevelopmental model of psychosis with further progressive mechanisms and are consistent with a primary involvement of left frontotemporal networks in the prodromal phase... - Basic symptoms and ultrahigh risk criteria: symptom development in the initial prodromal stateFrauke Schultze-Lutter
Department of Psychiatry and Psychotherapy, University of Cologne, 50924 Cologne, Germany
Schizophr Bull 36:182-91. 2010..However, as regards the criteria, the results support the notion of BS as at least a complementary approach to the ultrahigh risk criteria, which may also allow for an earlier detection of psychosis... - Randomized controlled multicentre trial of cognitive behaviour therapy in the early initial prodromal state: effects on social adjustment post treatmentAndreas Bechdolf
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
Early Interv Psychiatry 1:71-8. 2007.... - Unilateral deep brain stimulation of the nucleus accumbens in patients with treatment-resistant obsessive-compulsive disorder: Outcomes after one yearWolfgang Huff
Department of Psychiatry and Psychotherapy, University of Cologne, Germany
Clin Neurol Neurosurg 112:137-43. 2010..Predominantly bilateral stimulation of the anterior limb of the internal capsule was utilized... - Basic symptoms in early psychotic and depressive disordersFrauke Schultze-Lutter
University of Cologne, Department of Psychiatry and Psychotherapy, Early Recognition and Intervention Centre for Mental Crises FETZ, 50924 Cologne, Germany
Br J Psychiatry Suppl 51:s31-7. 2007..Depression is a frequent condition in early psychosis. Therefore, early detection instruments should distinguish depression from beginning psychosis... - Intervention in the at-risk state to prevent transition to psychosisStephan Ruhrmann
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
Curr Opin Psychiatry 22:177-83. 2009..The number of intervention studies aiming to prevent psychosis is still small. Follow-up data of the first studies were published during the last year and neuroprotection has become an important issue... - Prediction of psychosis by mismatch negativityMitja Bodatsch
Department of Psychiatry and Psychotherapy, University of Cologne, Germany
Biol Psychiatry 69:959-66. 2011..To this aim, mismatch negativity (MMN) was investigated in a sample clinically at high risk, comparing individuals with and without subsequent conversion to psychosis... - Anandamide levels in cerebrospinal fluid of first-episode schizophrenic patients: impact of cannabis useF Markus Leweke
Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Str 62, 50924 Cologne, Germany
Schizophr Res 94:29-36. 2007..In the present study we examined whether cannabis use may alter such a mechanism... - Impaired mismatch negativity generation in prodromal subjects and patients with schizophreniaAnke Brockhaus-Dumke
Department of Psychiatry and Psychotherapy, University of Cologne, Joseph Stelzmann Str 9, D 50924 Cologne, Germany
Schizophr Res 73:297-310. 2005..To elicit MMN, a three-tone auditory oddball paradigm with 10% 'duration deviants' and 10% 'frequency deviants' was used... - Rationale and baseline characteristics of PREVENT: a second-generation intervention trial in subjects at-risk (prodromal) of developing first-episode psychosis evaluating cognitive behavior therapy, aripiprazole, and placebo for the prevention of psychosiAndreas Bechdolf
Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Str 62, 50924 Cologne, Germany
Schizophr Bull 37:S111-21. 2011..When the final results of the trial are available, PREVENT will substantially expand the current limited evidence base for best clinical practice in people at-risk (prodromal) of first-episode psychosis... - The initial prodrome of schizophrenia: different duration, different underlying deficits?Frauke Schultze-Lutter
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
Compr Psychiatry 48:479-88. 2007.... - Sleep deprivation increases oleoylethanolamide in human cerebrospinal fluidDagmar Koethe
Department of Psychiatry and Psychotherapy, University of Cologne, 50924, Cologne, Germany
J Neural Transm 116:301-5. 2009..Thus, our results suggest that oleoylethanolamide release may represent an endogenous neuroprotective signal during sleep deprivation... - [The Cologne Early Recognition and Intervention Center for mental crises (FETZ). Evaluation of service use]Frauke Schultze-Lutter
Klinik fur Psychiatrie und Psychotherapie, Universitätsklinik Köln, Früh Erkennungs and Therapie Zentrum für psychische Krisen FETZ, Koln
Med Klin (Munich) 103:81-9. 2008..Following the German psychopathologic tradition, basic symptoms, especially cognitive-perceptive disturbances, are employed as a means to this aim in addition to the internationally established "ultra-high risk" (UHR) criteria... - Interventions in the initial prodromal states of psychosis in Germany: concept and recruitmentAndreas Bechdolf
Early Recognition and Intervention Centre for Mental Crisis FETZ, Department of Psychiatry and Psychotherapy, University of Cologne, Kerpenerstrasse 62, 50924 Cologne, Germany
Br J Psychiatry Suppl 48:s45-8. 2005..Two intervention strategies are being studied by two large-scale multicentre projects... - Cognitive-behavioral therapy in the pre-psychotic phase: an exploratory studyAndreas Bechdolf
Cologne Early Recognition and Intervention Centre for Mental Crisis FETZ, Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Str 62, 50924 Cologne, Germany
Psychiatry Res 136:251-5. 2005..The specificity of these effects needs to be explored in a controlled trial... - Neural correlates of visuo-spatial attention during an antisaccade task in schizophrenia: an ERP studyIndira Tendolkar
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
Int J Neurosci 115:681-98. 2005..Left temporo-occipitally, this activity was only evident in schizophrenia patients, possibly reflecting additional neuronal recruitment in order to perform the antisaccade task successfully... - Recent approaches to psychological interventions for people at risk of psychosisAndreas Bechdolf
Early Recognition and Intervention, Centre for Mental Crises FETZ, Department of Psychiatry and Psychotherapy, University of Cologne, Germany
Eur Arch Psychiatry Clin Neurosci 256:159-73. 2006.... - Probably at-risk, but certainly ill--advocating the introduction of a psychosis spectrum disorder in DSM-VStephan Ruhrmann
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
Schizophr Res 120:23-37. 2010..Following from this shift in the perception of current at-risk criteria, access to standard medical care would have to be granted, and diagnosis- or symptom- rather than conversion-related interventions would have to be developed... - Determinants of subjective quality of life in post acute patients with schizophreniaAndreas Bechdolf
Department of Psychiatry and Psychotherapy, University of Cologne, 50924 Cologne, Germany
Eur Arch Psychiatry Clin Neurosci 253:228-35. 2003..One could conclude that to enhance patients' QoL, improvements in depressive symptoms, negative coping style, social support and self-efficacy seem to be most effective... - Preventing progression to first-episode psychosis in early initial prodromal statesA Bechdolf
Department of Psychiatry and Psychotherapy, University of Cologne, Germany
Br J Psychiatry 200:22-9. 2012.... - Subjective quality of life in subjects at risk for a first episode of psychosis: a comparison with first episode schizophrenia patients and healthy controlsAndreas Bechdolf
Cologne Early Recognition and Intervention Centre for mental crises FETZ, Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Str 62, 50924 Cologne, Germany
Schizophr Res 79:137-43. 2005..These findings support the notion that subjects at risk for a first episode of psychosis constitute a clinical population for which further service and intervention research is indicated... - Intervention in at-risk states for developing psychosisStephan Ruhrmann
Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Strasse 62, 50924 Cologne, Germany
Eur Arch Psychiatry Clin Neurosci 260:S90-4. 2010..An overview on the current findings and ongoing research in this area is provided... - Pharmacological prevention and treatment in clinical at-risk states for psychosisStephan Ruhrmann
Department of Psychiatry and Psychotherapy, University of Cologne, Germany
Curr Pharm Des 18:550-7. 2012..Future prevention studies, however, need to solve the challenge of changing immediate transition rates, demanding for new risk enrichment strategies as a prerequisite for feasible trial designs... - Prediction of psychosis in adolescents and young adults at high risk: results from the prospective European prediction of psychosis studyStephan Ruhrmann
Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Strasse 62, 50924 Cologne, Germany
Arch Gen Psychiatry 67:241-51. 2010..Existing criteria need improvement in terms of specificity and individual risk assessment to allow for better targeted and earlier interventions... - Reliability and validity of Quality of Life assessed by the Short-Form 36 and the Modular System for Quality of Life in patients with schizophrenia and patients with depressionRalf Pukrop
Department of Psychiatry and Psychotherapy, University of Cologne, Joseph Stelzmann Str 9, 50924, Cologne, Germany
Psychiatry Res 119:63-79. 2003.... - Evidence for a dysfunctional retrosplenial cortex in patients with schizophrenia: a functional magnetic resonance imaging study with a semantic-perceptual contrastIndira Tendolkar
Department of Psychiatry, University of Cologne, Joseph Stelzmannstr 9, 50924 Cologne, Germany
Neurosci Lett 369:4-8. 2004..The impaired RS-PCC functionality in a semantic task may relate to verbal memory deficits frequently observed in schizophrenia patients, because this region is pivotal for gating information into the medial temporal lobe memory system... - Dimensions of working memory dysfunction in schizophreniaRalf Pukrop
Department of Psychiatry and Psychotherapy, University of Cologne, Joseph Stelzmann Str 9, 50928 Cologne, Germany
Schizophr Res 62:259-68. 2003..Schizophr. Bull. 27 (2001) 157]... - Neurocognitive indicators of clinical high-risk states for psychosis: a critical review of the evidenceRalf Pukrop
Department of Psychiatry and Psychotherapy, University of Cologne, Kerpener Str 62, 50937, Cologne, Germany
Neurotox Res 18:272-86. 2010..Finally, some reasons for inconsistent findings are discussed critically speculating on demographic differences, reliability and sample sizes, and conceptual imprecision in communicating results... - [Frontotemporal dementia]Raguna Nagy
Klinik fur Psychiatrie und Psychotherapie, Universitat zu Koln, Koln
Med Klin (Munich) 102:816-23. 2007..The estimated prevalence is 15:100,000 in the 45- to 64-year-old population; thus, it appears that the FTD as a cause for so-called presenile dementia is nearly as common as Alzheimer's disease... - Self-experienced vulnerability, prodromal symptoms and coping strategies preceding schizophrenic and depressive relapsesAndreas Bechdolf
Department of Psychiatry and Psychotherapy, University of Cologne, Joseph Stelzmann Str 9, 50924, Cologne, Germany
Eur Psychiatry 17:384-93. 2002.... - Pharmacological intervention in the initial prodromal phase of psychosisStephan Ruhrmann
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
Eur Psychiatry 20:1-6. 2005..The full benefits of early detection and intervention should be revealed once larger and longer studies are conducted... - A randomized comparison of group cognitive-behavioural therapy and group psychoeducation in acute patients with schizophrenia: outcome at 24 monthsA Bechdolf
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
Acta Psychiatr Scand 112:173-9. 2005..At 6-month follow-up, the CBT group had shown significantly less re-hospitalization rates and on a descriptive level higher compliance with medication... - [Motivational interviewing for patients with comorbid schizophrenia and substance abuse disorders: a review]A Bechdolf
Klinik für Psychiatrie und Psychotherapie der Universität zu Köln
Fortschr Neurol Psychiatr 73:728-35. 2005..This may be due to the methodological problems mentioned above or it may be that there is, in fact, no effect. Therefore, there is an urgent need for further research of MI in DD... - [Variety of symptoms after drug use of gamma-hydroxybutyric acid (GHB)]N Galldiks
Klinik und Poliklinik fur Neurologie, Uniklinik Köln, Kerpener Strasse 62, Koln
Fortschr Neurol Psychiatr 79:21-5. 2011..In this review, we summarise current data regarding the history, pharmacodynamics and pharmacokinetics of the drug as well as the relevant symptoms of intoxication or withdrawal as they pertain to neurology and psychiatry... - Reduced subjective quality of life in persons at risk for psychosisS Ruhrmann
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
Acta Psychiatr Scand 117:357-68. 2008..Subjective quality of life (sQoL) and potentially contributing factors were investigated in individuals putatively in an early (EIPS) or late initial prodromal state (LIPS) and healthy controls (HC)... - Acute effects of treatment for prodromal symptoms for people putatively in a late initial prodromal state of psychosisS Ruhrmann
Department of Psychiatry and Psychotherapy, University Hospital of the University of Cologne, Kerpener Strasse 62, 50924 Cologne, Germany
Br J Psychiatry Suppl 51:s88-95. 2007..People in a putatively late prodromal state not only have an enhanced risk for psychosis but already suffer from mental and functional disturbances... - Chances and risks of predicting psychosisStephan Ruhrmann
Department of Psychiatry and Psychotherapy, University of Cologne, 50924 Cologne, Germany
Eur Arch Psychiatry Clin Neurosci 262:S85-90. 2012..Thus, whether a risk model justifies preventive measures can only be decided by weighing the costs of unnecessary intervention and the benefits of avoiding a potentially devastating outcome... - Neural correlates of temporal context discriminationIndira Tendolkar
Department of Psychiatry, University of Cologne, Joseph Stelzmannstr 9, 50924 Cologne, Germany
Biol Psychol 66:235-55. 2004..The significance of these old/new effects are discussed in relation to the broader pattern of old/new effects seen in standard tests of declarative memory retrieval... - A randomized comparison of group cognitive-behavioural therapy and group psychoeducation in patients with schizophreniaA Bechdolf
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
Acta Psychiatr Scand 110:21-8. 2004..Although the efficacy of cognitive-behavioural therapy (CBT) in schizophrenia has been established in a number of studies, no information is available on the differential efficacy of CBT in comparison with patient psychoeducation (PE)... - Personality disorders and accentuations in at-risk persons with and without conversion to first-episode psychosisFrauke Schultze-Lutter
University Hospital of Child and Adolescent Psychiatry, Research Department, Bern, Switzerland
Early Interv Psychiatry 6:389-98. 2012..The role of PDs and personality accentuations (PAs) in predicting conversion to psychosis was studied in patients symptomatically considered at risk, assuming a major role of the schizotypal subtype... - Cannabis-associated psychosis: current status of researchF Markus Leweke
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
CNS Drugs 18:895-910. 2004..Long-term psychotherapeutic treatment options involve case management strategies and are mainly based on specialised psychotherapeutic programmes to encourage cannabis users to stop their use of the drug... - [Is the diagnosis of schizophrenic illness possible in the initial prodromal phase to the first psychotic manifestation?]J Klosterkotter
Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Universitat zu Koln
Fortschr Neurol Psychiatr 68:S13-21. 2000..Thus in future, an early intervention related to them might enable a prevention of first psychotic episodes... - Diagnosing schizophrenia in the initial prodromal phaseJ Klosterkotter
Department of Psychiatry and Psychotherapy, University of Cologne, Joseph Stelzmann Strasse 9, 50924 Cologne, Germany
Arch Gen Psychiatry 58:158-64. 2001..In schizophrenia research, early detection in the initial prodrome before first psychotic episodes is a major topic. Therefore, the prognostic accuracy of initial prodromal symptoms was examined prospectively... - Early detection and intervention in the initial prodromal phase of schizophreniaS Ruhrmann
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
Pharmacopsychiatry 36:S162-7. 2003..Initial study results targeting an earlier or later prodromal phase are promising, but longer follow-ups and larger samples are needed... - Morphometry of structural disconnectivity indicators in subjects at risk and in age-matched patients with schizophreniaRalf Tepest
Klinik fur Psychiatrie und Psychotherapie, Uniklinik Köln, Cologne, Germany
Eur Arch Psychiatry Clin Neurosci 263:15-24. 2013..The results are suggestive for impaired cortico-cortical connections as indicated by gyrification changes in SZ and also in SAR, whereas interhemispherical connectivity at the same time appears to be unaffected... - Deep brain stimulation for psychiatric disordersJens Kuhn
Klinik fur Psychiatrie und Psychotherapie, Klinikum der Universität zu Köln, Germany
Dtsch Arztebl Int 107:105-13. 2010..In a number of recently published case series, DBS yielded an impressive therapeutic benefit in patients with medically intractable psychiatric diseases... - Subjective and objective neuropsychological abnormalities in a psychosis prodrome clinicMartin Hambrecht
Department of Psychiatry and Psychotherapy, University of Cologne, Germany
Br J Psychiatry Suppl 43:s30-7. 2002..Predicting transitions to psychosis is difficult. Neuropsychology might facilitate predictions... - Determination of anandamide and other fatty acyl ethanolamides in human serum by electrospray tandem mass spectrometryDaniela Schreiber
Department of Psychiatry and Psychotherapy, University of Cologne, 50924 Cologne, Germany
Anal Biochem 361:162-8. 2007..025-25 pmol and for standard PEA and OEA over the range of 0.1-500 pmol. This method provides a time-saving and sensitive alternative to existing methods for the analysis of FAEs in biological samples... - Oxcarbazepine--efficacy and tolerability during treatment of alcohol withdrawal: a double-blind, randomized, placebo-controlled multicenter pilot studyDagmar Koethe
Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany
Alcohol Clin Exp Res 31:1188-94. 2007..Oxcarbazepine (OXC), a newer anticonvulsive drug, has a favorable safety profile over carbamazepine (CBZ) and other older AEDs due to its excellent efficacy and better side-effect profile... - The nucleus accumbens: a target for deep brain stimulation in obsessive-compulsive- and anxiety-disordersVolker Sturm
Department of Stereotactic and Functional Neurosurgery, University of Cologne, 50924, Koln, Germany
J Chem Neuroanat 26:293-9. 2003.... - Remembering or knowing: electrophysiological evidence for an episodic memory deficit in schizophreniaI Tendolkar
Department of Psychiatry and Psychotherapy, University of Cologne, Germany
Psychol Med 32:1261-71. 2002..The more widespread frontal Know old/new effect in the patients suggests that the prefrontly mediated processes associated with retrieval of semantic memory may be enhanced compensatorily... - Early self-experienced neuropsychological deficits and subsequent schizophrenic diseases: an 8-year average follow-up prospective studyJ Klosterkotter
Psychiatric Department, University of Cologne, Germany
Acta Psychiatr Scand 95:396-404. 1997..These findings suggest that certain self-experienced neuropsychological deficits are able to indicate susceptibility to psychosis...