Research Topics
| Stefan KloppelSummaryAffiliation: University Hospital Country: Germany Publications
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Detail Information
Publications
Diagnostic neuroimaging across diseasesStefan Kloppel
Department of Psychiatry and Psychotherapy, Section of Gerontopsychiatry and Neuropsychology, Freiburg Brain Imaging, University Medical Center Freiburg, Hauptstrasse 5, Freiburg, Germany
Neuroimage 61:457-63. 2012..Specifically, we discuss strategies to deal with disease heterogeneity, diagnostic uncertainties, a probabilistic framework for classification and multi-class classification approaches...- Magnetic resonance imaging of Huntington's disease: preparing for clinical trialsS Kloppel
Department of Psychiatry and Psychotherapy, Freiburg Brain Imaging, University Clinic Freiburg, Freiburg, Germany
Neuroscience 164:205-19. 2009..There may also be biological explanations but these are poorly characterized and understood at present. Additional insights into this phenotypic variability derived from study of mouse models are presented to explore this phenomenon... - Irritability in pre-clinical Huntington's diseaseStefan Kloppel
Department of Psychiatry and Psychotherapy, Freiburg Brain Imaging, University Clinic Freiburg, Freiburg, Germany
Neuropsychologia 48:549-57. 2010..At later stages, this dysfunction may increase the risk for developing recognised, HD-associated, psychiatric symptoms such as irritability... 
Brain morphometry and functional imaging techniques in dementia: methods, findings and relevance in forensic neurologyStefan Kloppel
Department of Psychiatry and Psychotherapy, University Hospital Freiburg, Freiburg, Germany
Curr Opin Neurol 22:612-6. 2009..These two situations will be used to structure a review of the literature in this general area...- Functional compensation of motor function in pre-symptomatic Huntington's diseaseStefan Kloppel
Department of Psychiatry und Psychotherapy, Hauptstrasse 5, Freiburg, Germany
Brain 132:1624-32. 2009..Critically, the pattern of motor compensation is flexible depending on the actual task demands on motor control... - Automatic detection of preclinical neurodegeneration: presymptomatic Huntington diseaseS Kloppel
Department of Psychiatry and Psychotherapy, Freiburg Brain Imaging, University Clinic Freiburg, Germany
Neurology 72:426-31. 2009..The availability of a definitive genetic test for Huntington disease (HD) provides an excellent metric for judging the performance of such methods in gene mutation carriers who are free of symptoms... - [New possibilities for automated diagnosis of dementia]S Kloppel
Neurozentrum, Freiburg Brain Imaging, Zentrum für Geriatrie und Gerontologie, Abteilung für Psychiatrie und Psychotherapie, Universitatsklinikum Freiburg, Hauptstraße 5, 79104, Freiburg
Nervenarzt 81:1456-9. 2010..Extension, based e.g. on resting state functional imaging are possible but are further away from clinical routine... - Accuracy of dementia diagnosis: a direct comparison between radiologists and a computerized methodStefan Kloppel
Department of Psychiatry and Psychotherapy and Freiburg Brain Imaging, University Clinic Freiburg, Freiburg, Germany
Brain 131:2969-74. 2008..These results are encouraging and indicate a role for computerized diagnostic methods in clinical practice... - Nurture versus nature: long-term impact of forced right-handedness on structure of pericentral cortex and basal gangliaStefan Kloppel
Department of Psychiatry and Psychotherapy, Freiburg Brain Imaging, University Clinic Freiburg, Freiburg, Germany
J Neurosci 30:3271-5. 2010..This indicates a differential response of the basal ganglia to early environmental challenges, possibly related to processes of pruning during motor development... 
White matter connections reflect changes in voluntary-guided saccades in pre-symptomatic Huntington's diseaseStefan Kloppel
Wellcome Trust Centre for Neuroimaging, Institute if Neurology, UCL, London, UK
Brain 131:196-204. 2008..Our findings suggest a specific patho-physiological basis for these symptoms by indicating selective vulnerability of the associated white matter tracts...- Automatic classification of MR scans in Alzheimer's diseaseStefan Kloppel
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK
Brain 131:681-9. 2008..Thirdly, the method is robust and can be generalized across different centres. This suggests an important role for computer based diagnostic image analysis for clinical practice... - The cortical motor threshold reflects microstructural properties of cerebral white matterStefan Kloppel
Department of Neurology, Neurozentrum, University Clinic Freiburg, Freiburg, Germany
Neuroimage 40:1782-91. 2008.... - A comparison of different automated methods for the detection of white matter lesions in MRI dataStefan Kloppel
Department of Psychiatry and Psychotherapy, Section for Gerontopsychiatry, University Medical Center Freiburg, Germany
Neuroimage 57:416-22. 2011..The study demonstrates advantages of SVM for the problem of detecting WMH at least for studies that include only FLAIR and T1 weighted images. Various optimization strategies are discussed and compared against each other... - Damage to ventral and dorsal language pathways in acute aphasiaDorothee Kümmerer
Department of Neurology, University Medical Centre Freiburg, Breisacher Strasse 64, 79106 Freiburg, Germany
Brain 136:619-29. 2013..Particularly, this is the first lesion study demonstrating that task performance on auditory comprehension measures requires an interaction between temporal and prefrontal brain regions via the ventral extreme capsule pathway... - Evidence for segregated and integrative connectivity patterns in the human Basal GangliaBogdan Draganski
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London WC1N 3BG, United Kingdom
J Neurosci 28:7143-52. 2008..We believe that this method can be used to examine pathophysiological concepts in a number of basal ganglia-related disorders... - Early functional magnetic resonance imaging activations predict language outcome after strokeDorothee Saur
Department of Neurology, University Medical Centre Freiburg, Freiburg, Germany
Brain 133:1252-64. 2010..More intensive early rehabilitation could be provided for those with a predicted poor recovery and the extension to other systems, for example, motor and attention seems feasible... - Interpreting scan data acquired from multiple scanners: a study with Alzheimer's diseaseCynthia M Stonnington
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK
Neuroimage 39:1180-5. 2008..Similar analyses in other multi-scanner data-sets could be used to justify the pooling of data when needed, such as in studies of rare disorders or in multi-center designs... - Neural correlates of interference inhibition, action withholding and action cancelation in adult ADHDAlexandra Sebastian
Department of Psychiatry and Psychotherapy, Albert Ludwigs University Freiburg, Germany
Psychiatry Res 202:132-41. 2012.... - Effects of hardware heterogeneity on the performance of SVM Alzheimer's disease classifierAhmed Abdulkadir
Department of Psychiatry and Psychotherapy, Freiburg Brain Imaging, University Medical Center Freiburg, Freiburg, Germany
Neuroimage 58:785-92. 2011..Furthermore, we show that the level of confidence in the performance estimation significantly depends on the size of the training sample, and hence should be taken into account in a clinical setting... - Voxel-based morphometry in eating disorders: correlation of psychopathology with grey matter volumeAndreas Joos
Department of Psychosomatic Medicine and Psychotherapy, University of Freiburg, Hauptstrasse 8, Freiburg, Germany
Psychiatry Res 182:146-51. 2010.... - The NMDA agonist D-cycloserine facilitates fear memory consolidation in humansRaffael Kalisch
Functional Imaging Laboratory, Wellcome Department of Imaging Neuroscience, University College London, London, UK
Cereb Cortex 19:187-96. 2009..DCS also enhanced CS-evoked neural responses in a posterior hippocampus/collateral sulcus region and in the medial prefrontal cortex at test. Our data suggest a role for NMDA receptors in regulating fear memory consolidation in humans... - Multivariate models of inter-subject anatomical variabilityJohn Ashburner
Wellcome Trust Centre for Neuroimaging, London, UK
Neuroimage 56:422-39. 2011..Knowledge of some basic linear algebra and probability theory should make the review easier to follow, although it may still have something to offer to those readers whose mathematics may be more limited... - Blocking central opiate function modulates hedonic impact and anterior cingulate response to rewards and lossesPredrag Petrovic
Wellcome Trust Centre for Neuroimaging, University College London, London WC1N 3BG, United Kingdom
J Neurosci 28:10509-16. 2008..Our data indicate that a central opioid system contributes to both reward and loss processing in humans and directly modulates the hedonic experience of outcomes... - Combining functional and anatomical connectivity reveals brain networks for auditory language comprehensionDorothee Saur
Department of Neurology, Medical Physics, University Medical Center Freiburg, D 79106 Freiburg, Germany
Neuroimage 49:3187-97. 2010..Combining dPC with probabilistic tractography is a promising approach to unveil how cognitive functions emerge through interaction of functionally interacting and anatomically interconnected brain regions... - Insomnia Does Not Appear to be Associated With Substantial Structural Brain ChangesKai Spiegelhalder
Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Germany
Sleep 36:731-7. 2013..The goal of the current study was to investigate brain morphometry in a well-characterized large sample of patients with primary insomnia (PI) in comparison with good sleeper controls... - Functional and structural MRI biomarkers to detect pre-clinical neurodegenerationAhmed Abdulkadir
Department of Psychiatry and Psychotherapy, Section of Gerontopsychiatry and Neuropsychology, Freiburg Brain Imaging, University Medical Center Freiburg, Freiburg, Germany
Curr Alzheimer Res 10:125-34. 2013..However, the lower variability and easier processing of the strucutral MRI data make latter the more useful tool for disease detection in a clinical setting... - Pitfalls in the use of voxel-based morphometry as a biomarker: examples from huntington diseaseS M D Henley
Dementia Research Centre, Department of Neurodegenerative Disease, Institute of Neurology, University College London, United Kingdom
AJNR Am J Neuroradiol 31:711-9. 2010.... - Stability of white matter changes related to Huntington's disease in the presence of imaging noise: a DTI studyHans Peter Müller
Dept of Neurology, University of Ulm, Ulm, Germany Freiburg Brain Imaging, Department of Neurology, University Freiburg Medical Center, Germany Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, UK Department of Neuroradiology, University Medical Center Freiburg, Germany Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK and Freiburg Brain Imaging, Department of Psychiatry and Psychotherapy University of Freiburg
PLoS Curr 3:RRN1232. 2011..These findings demonstrate the robustness of the FA value in the presence of movement and thus encourage multi-center imaging studies in HD... - Dynamic causal modeling: a generative model of slice timing in fMRIStefan J Kiebel
The Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3AR, UK
Neuroimage 34:1487-96. 2007..We apply our procedure to real data and show that slice timings are important parameters. We conclude that, generally, one should use DCM with slice timing... - Genotype-phenotype interactions in primary dystonias revealed by differential changes in brain structureB Draganski
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, UK
Neuroimage 47:1141-7. 2009..Alternatively, a DYT1 gene dependent primary defect of motor circuit development may lead to stress-induced remodelling of the basal ganglia and hence dystonia...