Stefan Kloppel

Summary

Affiliation: University Hospital
Country: Germany

Publications

  1. pmc Diagnostic neuroimaging across diseases
    Stefan Kloppel
    Department of Psychiatry and Psychotherapy, Section of Gerontopsychiatry and Neuropsychology, Freiburg Brain Imaging, University Medical Center Freiburg, Hauptstrasse 5, Freiburg, Germany
    Neuroimage 61:457-63. 2012
  2. pmc Irritability in pre-clinical Huntington's disease
    Stefan Kloppel
    Department of Psychiatry and Psychotherapy, Freiburg Brain Imaging, University Clinic Freiburg, Freiburg, Germany
    Neuropsychologia 48:549-57. 2010
  3. pmc Magnetic resonance imaging of Huntington's disease: preparing for clinical trials
    S Kloppel
    Department of Psychiatry and Psychotherapy, Freiburg Brain Imaging, University Clinic Freiburg, Freiburg, Germany
    Neuroscience 164:205-19. 2009
  4. pmc Functional compensation of motor function in pre-symptomatic Huntington's disease
    Stefan Kloppel
    Department of Psychiatry und Psychotherapy, Hauptstrasse 5, Freiburg, Germany
    Brain 132:1624-32. 2009
  5. pmc Automatic detection of preclinical neurodegeneration: presymptomatic Huntington disease
    S Kloppel
    Department of Psychiatry and Psychotherapy, Freiburg Brain Imaging, University Clinic Freiburg, Germany
    Neurology 72:426-31. 2009
  6. doi request reprint Nurture versus nature: long-term impact of forced right-handedness on structure of pericentral cortex and basal ganglia
    Stefan Kloppel
    Department of Psychiatry and Psychotherapy, Freiburg Brain Imaging, University Clinic Freiburg, Freiburg, Germany
    J Neurosci 30:3271-5. 2010
  7. pmc Accuracy of dementia diagnosis: a direct comparison between radiologists and a computerized method
    Stefan Kloppel
    Department of Psychiatry and Psychotherapy and Freiburg Brain Imaging, University Clinic Freiburg, Freiburg, Germany
    Brain 131:2969-74. 2008
  8. doi request reprint [New possibilities for automated diagnosis of dementia]
    S Kloppel
    Neurozentrum, Freiburg Brain Imaging, Zentrum für Geriatrie und Gerontologie, Abteilung für Psychiatrie und Psychotherapie, Universitatsklinikum Freiburg, Hauptstraße 5, 79104, Freiburg
    Nervenarzt 81:1456-9. 2010
  9. doi request reprint A comparison of different automated methods for the detection of white matter lesions in MRI data
    Stefan Kloppel
    Department of Psychiatry and Psychotherapy, Section for Gerontopsychiatry, University Medical Center Freiburg, Germany
    Neuroimage 57:416-22. 2011
  10. doi request reprint The cortical motor threshold reflects microstructural properties of cerebral white matter
    Stefan Kloppel
    Department of Neurology, Neurozentrum, University Clinic Freiburg, Freiburg, Germany
    Neuroimage 40:1782-91. 2008

Detail Information

Publications33

  1. pmc Diagnostic neuroimaging across diseases
    Stefan Kloppel
    Department of Psychiatry and Psychotherapy, Section of Gerontopsychiatry and Neuropsychology, Freiburg Brain Imaging, University Medical Center Freiburg, Hauptstrasse 5, Freiburg, Germany
    Neuroimage 61:457-63. 2012
    ..Specifically, we discuss strategies to deal with disease heterogeneity, diagnostic uncertainties, a probabilistic framework for classification and multi-class classification approaches...
  2. pmc Irritability in pre-clinical Huntington's disease
    Stefan Kloppel
    Department of Psychiatry and Psychotherapy, Freiburg Brain Imaging, University Clinic Freiburg, Freiburg, Germany
    Neuropsychologia 48:549-57. 2010
    ..At later stages, this dysfunction may increase the risk for developing recognised, HD-associated, psychiatric symptoms such as irritability...
  3. pmc Magnetic resonance imaging of Huntington's disease: preparing for clinical trials
    S Kloppel
    Department of Psychiatry and Psychotherapy, Freiburg Brain Imaging, University Clinic Freiburg, Freiburg, Germany
    Neuroscience 164:205-19. 2009
    ..There may also be biological explanations but these are poorly characterized and understood at present. Additional insights into this phenotypic variability derived from study of mouse models are presented to explore this phenomenon...
  4. pmc Functional compensation of motor function in pre-symptomatic Huntington's disease
    Stefan Kloppel
    Department of Psychiatry und Psychotherapy, Hauptstrasse 5, Freiburg, Germany
    Brain 132:1624-32. 2009
    ..Critically, the pattern of motor compensation is flexible depending on the actual task demands on motor control...
  5. pmc Automatic detection of preclinical neurodegeneration: presymptomatic Huntington disease
    S Kloppel
    Department of Psychiatry and Psychotherapy, Freiburg Brain Imaging, University Clinic Freiburg, Germany
    Neurology 72:426-31. 2009
    ..The availability of a definitive genetic test for Huntington disease (HD) provides an excellent metric for judging the performance of such methods in gene mutation carriers who are free of symptoms...
  6. doi request reprint Nurture versus nature: long-term impact of forced right-handedness on structure of pericentral cortex and basal ganglia
    Stefan Kloppel
    Department of Psychiatry and Psychotherapy, Freiburg Brain Imaging, University Clinic Freiburg, Freiburg, Germany
    J Neurosci 30:3271-5. 2010
    ..This indicates a differential response of the basal ganglia to early environmental challenges, possibly related to processes of pruning during motor development...
  7. pmc Accuracy of dementia diagnosis: a direct comparison between radiologists and a computerized method
    Stefan Kloppel
    Department of Psychiatry and Psychotherapy and Freiburg Brain Imaging, University Clinic Freiburg, Freiburg, Germany
    Brain 131:2969-74. 2008
    ..These results are encouraging and indicate a role for computerized diagnostic methods in clinical practice...
  8. doi request reprint [New possibilities for automated diagnosis of dementia]
    S Kloppel
    Neurozentrum, Freiburg Brain Imaging, Zentrum für Geriatrie und Gerontologie, Abteilung für Psychiatrie und Psychotherapie, Universitatsklinikum Freiburg, Hauptstraße 5, 79104, Freiburg
    Nervenarzt 81:1456-9. 2010
    ..Extension, based e.g. on resting state functional imaging are possible but are further away from clinical routine...
  9. doi request reprint A comparison of different automated methods for the detection of white matter lesions in MRI data
    Stefan Kloppel
    Department of Psychiatry and Psychotherapy, Section for Gerontopsychiatry, University Medical Center Freiburg, Germany
    Neuroimage 57:416-22. 2011
    ..The study demonstrates advantages of SVM for the problem of detecting WMH at least for studies that include only FLAIR and T1 weighted images. Various optimization strategies are discussed and compared against each other...
  10. doi request reprint The cortical motor threshold reflects microstructural properties of cerebral white matter
    Stefan Kloppel
    Department of Neurology, Neurozentrum, University Clinic Freiburg, Freiburg, Germany
    Neuroimage 40:1782-91. 2008
    ....
  11. pmc Automatic classification of MR scans in Alzheimer's disease
    Stefan Kloppel
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK
    Brain 131:681-9. 2008
    ..Thirdly, the method is robust and can be generalized across different centres. This suggests an important role for computer based diagnostic image analysis for clinical practice...
  12. ncbi request reprint White matter connections reflect changes in voluntary-guided saccades in pre-symptomatic Huntington's disease
    Stefan Kloppel
    Wellcome Trust Centre for Neuroimaging, Institute if Neurology, UCL, London, UK
    Brain 131:196-204. 2008
    ..Our findings suggest a specific patho-physiological basis for these symptoms by indicating selective vulnerability of the associated white matter tracts...
  13. doi request reprint Brain morphometry and functional imaging techniques in dementia: methods, findings and relevance in forensic neurology
    Stefan Kloppel
    Department of Psychiatry and Psychotherapy, University Hospital Freiburg, Freiburg, Germany
    Curr Opin Neurol 22:612-6. 2009
    ..These two situations will be used to structure a review of the literature in this general area...
  14. pmc Damage to ventral and dorsal language pathways in acute aphasia
    Dorothee Kümmerer
    Department of Neurology, University Medical Centre Freiburg, Breisacher Strasse 64, 79106 Freiburg, Germany
    Brain 136:619-29. 2013
    ..Particularly, this is the first lesion study demonstrating that task performance on auditory comprehension measures requires an interaction between temporal and prefrontal brain regions via the ventral extreme capsule pathway...
  15. doi request reprint Evidence for segregated and integrative connectivity patterns in the human Basal Ganglia
    Bogdan Draganski
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London WC1N 3BG, United Kingdom
    J Neurosci 28:7143-52. 2008
    ..We believe that this method can be used to examine pathophysiological concepts in a number of basal ganglia-related disorders...
  16. pmc Interpreting scan data acquired from multiple scanners: a study with Alzheimer's disease
    Cynthia M Stonnington
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, London, UK
    Neuroimage 39:1180-5. 2008
    ..Similar analyses in other multi-scanner data-sets could be used to justify the pooling of data when needed, such as in studies of rare disorders or in multi-center designs...
  17. doi request reprint Early functional magnetic resonance imaging activations predict language outcome after stroke
    Dorothee Saur
    Department of Neurology, University Medical Centre Freiburg, Freiburg, Germany
    Brain 133:1252-64. 2010
    ..More intensive early rehabilitation could be provided for those with a predicted poor recovery and the extension to other systems, for example, motor and attention seems feasible...
  18. doi request reprint Interregional compensatory mechanisms of motor functioning in progressing preclinical neurodegeneration
    Elisa Scheller
    Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Hauptstrasse 5, 79104 Freiburg, Germany
    Neuroimage 75:146-54. 2013
    ....
  19. ncbi request reprint Functional and structural MRI biomarkers to detect pre-clinical neurodegeneration
    Ahmed Abdulkadir
    Department of Psychiatry and Psychotherapy, Section of Gerontopsychiatry and Neuropsychology, Freiburg Brain Imaging, University Medical Center Freiburg, Freiburg, Germany
    Curr Alzheimer Res 10:125-34. 2013
    ..However, the lower variability and easier processing of the strucutral MRI data make latter the more useful tool for disease detection in a clinical setting...
  20. doi request reprint Neural correlates of interference inhibition, action withholding and action cancelation in adult ADHD
    Alexandra Sebastian
    Department of Psychiatry and Psychotherapy, Albert Ludwigs University Freiburg, Germany
    Psychiatry Res 202:132-41. 2012
    ....
  21. pmc Effects of hardware heterogeneity on the performance of SVM Alzheimer's disease classifier
    Ahmed Abdulkadir
    Department of Psychiatry and Psychotherapy, Freiburg Brain Imaging, University Medical Center Freiburg, Freiburg, Germany
    Neuroimage 58:785-92. 2011
    ..Furthermore, we show that the level of confidence in the performance estimation significantly depends on the size of the training sample, and hence should be taken into account in a clinical setting...
  22. pmc The NMDA agonist D-cycloserine facilitates fear memory consolidation in humans
    Raffael Kalisch
    Functional Imaging Laboratory, Wellcome Department of Imaging Neuroscience, University College London, London, UK
    Cereb Cortex 19:187-96. 2009
    ..DCS also enhanced CS-evoked neural responses in a posterior hippocampus/collateral sulcus region and in the medial prefrontal cortex at test. Our data suggest a role for NMDA receptors in regulating fear memory consolidation in humans...
  23. doi request reprint Voxel-based morphometry in eating disorders: correlation of psychopathology with grey matter volume
    Andreas Joos
    Department of Psychosomatic Medicine and Psychotherapy, University of Freiburg, Hauptstrasse 8, Freiburg, Germany
    Psychiatry Res 182:146-51. 2010
    ....
  24. pmc Blocking central opiate function modulates hedonic impact and anterior cingulate response to rewards and losses
    Predrag Petrovic
    Wellcome Trust Centre for Neuroimaging, University College London, London WC1N 3BG, United Kingdom
    J Neurosci 28:10509-16. 2008
    ..Our data indicate that a central opioid system contributes to both reward and loss processing in humans and directly modulates the hedonic experience of outcomes...
  25. pmc Multivariate models of inter-subject anatomical variability
    John Ashburner
    Wellcome Trust Centre for Neuroimaging, London, UK
    Neuroimage 56:422-39. 2011
    ..Knowledge of some basic linear algebra and probability theory should make the review easier to follow, although it may still have something to offer to those readers whose mathematics may be more limited...
  26. doi request reprint Combining functional and anatomical connectivity reveals brain networks for auditory language comprehension
    Dorothee Saur
    Department of Neurology, Medical Physics, University Medical Center Freiburg, D 79106 Freiburg, Germany
    Neuroimage 49:3187-97. 2010
    ..Combining dPC with probabilistic tractography is a promising approach to unveil how cognitive functions emerge through interaction of functionally interacting and anatomically interconnected brain regions...
  27. doi request reprint Gray matter atrophy pattern in elderly with subjective memory impairment
    Jessica Peter
    Freiburg Brain Imaging, University Medical Center Freiburg, Freiburg, Germany Department of Neurology, University Medical Center Freiburg, Freiburg, Germany Department of Psychology, Laboratory for Biological and Personality Psychology, University of Freiburg, Freiburg, Germany Electronic address
    Alzheimers Dement 10:99-108. 2014
    ..Despite normal cognitive performance, they may be at higher risk of cognitive decline compared with individuals without SMI...
  28. doi request reprint Detection of preclinical neural dysfunction from functional connectivity graphs derived from task fMRI. An example from degeneration
    Yolanda Vives-Gilabert
    Freiburg Brain Imaging, University of Freiburg, Freiburg, Germany Port d Informació Científica PIC, Campus UAB Edifici D, Bellaterra, Spain Electronic address
    Psychiatry Res 214:322-30. 2013
    ..Developing methods that reduce variability related to noise should be the focus of future studies. ..
  29. pmc Insomnia does not appear to be associated with substantial structural brain changes
    Kai Spiegelhalder
    Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Germany
    Sleep 36:731-7. 2013
    ..The goal of the current study was to investigate brain morphometry in a well-characterized large sample of patients with primary insomnia (PI) in comparison with good sleeper controls...
  30. doi request reprint Pitfalls in the use of voxel-based morphometry as a biomarker: examples from huntington disease
    S M D Henley
    Dementia Research Centre, Department of Neurodegenerative Disease, Institute of Neurology, University College London, United Kingdom
    AJNR Am J Neuroradiol 31:711-9. 2010
    ..However, although it is largely "automated," VBM is rarely implemented consistently across studies, and changing user-specified options can alter the results in a way similar to the very biologic differences under investigation...
  31. pmc Stability of white matter changes related to Huntington's disease in the presence of imaging noise: a DTI study
    Hans Peter Müller
    Dept of Neurology, University of Ulm, Ulm, Germany Freiburg Brain Imaging, Department of Neurology, University Freiburg Medical Center, Germany Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, UK Department of Neuroradiology, University Medical Center Freiburg, Germany Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK and Freiburg Brain Imaging, Department of Psychiatry and Psychotherapy University of Freiburg
    PLoS Curr 3:RRN1232. 2011
    ..These findings demonstrate the robustness of the FA value in the presence of movement and thus encourage multi-center imaging studies in HD...
  32. ncbi request reprint Dynamic causal modeling: a generative model of slice timing in fMRI
    Stefan J Kiebel
    The Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3AR, UK
    Neuroimage 34:1487-96. 2007
    ..We apply our procedure to real data and show that slice timings are important parameters. We conclude that, generally, one should use DCM with slice timing...
  33. pmc Genotype-phenotype interactions in primary dystonias revealed by differential changes in brain structure
    B Draganski
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, UCL, UK
    Neuroimage 47:1141-7. 2009
    ..Alternatively, a DYT1 gene dependent primary defect of motor circuit development may lead to stress-induced remodelling of the basal ganglia and hence dystonia...