Gunter Kloppel

Summary

Affiliation: University of Kiel
Country: Germany

Publications

  1. pmc Pancreatic intraductal papillary-mucinous neoplasms: a new and evolving entity
    Snezana Andrejevic-Blant
    Institute of Pathology, Faculty of Medicine and Biology, University of Lausanne, Lausanne, Switzerland
    Virchows Arch 451:863-9. 2007
  2. pmc A prospective, non-randomized phase II trial of Trastuzumab and Capecitabine in patients with HER2 expressing metastasized pancreatic cancer
    Andre Mihaljevic
    Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg and Klinikum rechts der Isar, Technische Universität Munich, Ismaninger Strasse 22, 81675 Munich, Germany
    BMC Surg 9:1. 2009
  3. pmc Characterisation of a transgenic mouse expressing R122H human cationic trypsinogen
    Lena Selig
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Leipzig, Leipzig, Germany
    BMC Gastroenterol 6:30. 2006
  4. ncbi Adult diffuse nesidioblastosis: genetically or environmentally induced?
    Gunter Kloppel
    Department of Pathology, University of Kiel, 24105 Kiel, Germany
    Hum Pathol 39:3-8. 2008
  5. ncbi Endocrine precursor lesions of gastroenteropancreatic neuroendocrine tumors
    Gunter Kloppel
    Department of Pathology, University of Kiel, Michaelisstr 11, 24105, Kiel, Germany
    Endocr Pathol 18:150-5. 2007
  6. ncbi Gastrinoma--morphological aspects
    Gunter Kloppel
    Department of Pathology, University of Kiel, Kiel, Germany
    Wien Klin Wochenschr 119:579-84. 2007
  7. ncbi Oberndorfer and his successors: from carcinoid to neuroendocrine carcinoma
    Gunter Kloppel
    Department of Pathology, University of Kiel, Michaelisstr 11, 24105, Kiel, Germany
    Endocr Pathol 18:141-4. 2007
  8. ncbi Siegfried Oberndorfer: a tribute to his work and life between Munich, Kiel, Geneva, and Istanbul
    Gunter Kloppel
    Department of Pathology, University of Kiel, Michaelisstr 11, 24105, Kiel, Germany
    Virchows Arch 451:S3-7. 2007
  9. ncbi Site-specific biology and pathology of gastroenteropancreatic neuroendocrine tumors
    Gunter Kloppel
    Department of Pathology, University of Kiel, Michaelisstr 11, 24105, Kiel, Germany
    Virchows Arch 451:S9-27. 2007
  10. doi Chronic pancreatitis and the differential diagnosis versus pancreatic cancer
    Gunter Kloppel
    Department of Pathology, Universityof Kiel, House 14, Arnold Heller Str 3, 24105 Kiel, Germany
    Arch Pathol Lab Med 133:382-7. 2009

Detail Information

Publications79

  1. pmc Pancreatic intraductal papillary-mucinous neoplasms: a new and evolving entity
    Snezana Andrejevic-Blant
    Institute of Pathology, Faculty of Medicine and Biology, University of Lausanne, Lausanne, Switzerland
    Virchows Arch 451:863-9. 2007
    ..Their stratification reveals that the various intraductal papillary-mucinous neoplasm subtypes have different biological properties with different prognostic implications...
  2. pmc A prospective, non-randomized phase II trial of Trastuzumab and Capecitabine in patients with HER2 expressing metastasized pancreatic cancer
    Andre Mihaljevic
    Department of General Surgery, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg and Klinikum rechts der Isar, Technische Universität Munich, Ismaninger Strasse 22, 81675 Munich, Germany
    BMC Surg 9:1. 2009
    ..While in breast cancer HER2 has already been successfully used as a treatment target, there are only limited data evaluating the effects of inhibiting HER2 tyrosine kinases in patients with pancreatic cancer...
  3. pmc Characterisation of a transgenic mouse expressing R122H human cationic trypsinogen
    Lena Selig
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Leipzig, Leipzig, Germany
    BMC Gastroenterol 6:30. 2006
    ..The R122H mutation of the cationic trypsinogen was found in patients with hereditary pancreatitis. A transgenic animal carrying this mutation could be useful as a genetic model system of pancreatitis...
  4. ncbi Adult diffuse nesidioblastosis: genetically or environmentally induced?
    Gunter Kloppel
    Department of Pathology, University of Kiel, 24105 Kiel, Germany
    Hum Pathol 39:3-8. 2008
    ....
  5. ncbi Endocrine precursor lesions of gastroenteropancreatic neuroendocrine tumors
    Gunter Kloppel
    Department of Pathology, University of Kiel, Michaelisstr 11, 24105, Kiel, Germany
    Endocr Pathol 18:150-5. 2007
    ..The endocrine cell hyperplasia in the colon described in inflammatory bowel disease has neither a genetic nor a definite hormonal background...
  6. ncbi Gastrinoma--morphological aspects
    Gunter Kloppel
    Department of Pathology, University of Kiel, Kiel, Germany
    Wien Klin Wochenschr 119:579-84. 2007
    ..The prognosis of duodenal gastrinomas is better than that of pancreatic gastrinomas, since despite early lymph node metastasis they progress slowly to liver metastasis...
  7. ncbi Oberndorfer and his successors: from carcinoid to neuroendocrine carcinoma
    Gunter Kloppel
    Department of Pathology, University of Kiel, Michaelisstr 11, 24105, Kiel, Germany
    Endocr Pathol 18:141-4. 2007
    ..For the gastroenteropancreatic neuroendocrine tumors, this resulted in a new World Health Organization classification that was recently followed by a tumor-nodes-metastasis classification...
  8. ncbi Siegfried Oberndorfer: a tribute to his work and life between Munich, Kiel, Geneva, and Istanbul
    Gunter Kloppel
    Department of Pathology, University of Kiel, Michaelisstr 11, 24105, Kiel, Germany
    Virchows Arch 451:S3-7. 2007
    ..This article pursues the questions why this discovery was so unique and what role it played in the later life of Siegfried Oberndorfer...
  9. ncbi Site-specific biology and pathology of gastroenteropancreatic neuroendocrine tumors
    Gunter Kloppel
    Department of Pathology, University of Kiel, Michaelisstr 11, 24105, Kiel, Germany
    Virchows Arch 451:S9-27. 2007
    ..In addition, a tumor/nodes/metastases classification and a grading system are presented. In the light of these criteria, the various GEP-NET entities are reviewed...
  10. doi Chronic pancreatitis and the differential diagnosis versus pancreatic cancer
    Gunter Kloppel
    Department of Pathology, Universityof Kiel, House 14, Arnold Heller Str 3, 24105 Kiel, Germany
    Arch Pathol Lab Med 133:382-7. 2009
    ..Distinguishing chronic pancreatitis from pancreatic ductal adenocarcinoma (PDAC) is a well-known challenge, at both the clinical and the morphologic level...
  11. ncbi Tumour biology and histopathology of neuroendocrine tumours
    Gunter Kloppel
    Department of Pathology, University of Kiel, Michaelisstr 11, 24105 Kiel, Germany
    Best Pract Res Clin Endocrinol Metab 21:15-31. 2007
    ..Their clinical behaviour--ranging from benign and low-grade to high-grade malignancy--can be predicted on the basis of clinicopathological criteria. Currently extensive work is being performed to unravel the genetic background...
  12. doi Somatostatin-producing neuroendocrine tumors of the duodenum and pancreas: incidence, types, biological behavior, association with inherited syndromes, and functional activity
    Nele Garbrecht
    Department of Pathology, University of Kiel, Michaelisstr 11, Kiel, Germany
    Endocr Relat Cancer 15:229-41. 2008
    ..MEN1-associated SOM-NETs and GCPGs follow a benign course, while somatostatin-producing pdNECs are aggressive neoplasms. The occurrence of the so-called somatostatinoma syndrome appears to be extremely uncommon...
  13. ncbi Multiple endocrine neoplasia type 1 (MEN1): loss of one MEN1 allele in tumors and monohormonal endocrine cell clusters but not in islet hyperplasia of the pancreas
    Aurel Perren
    Institute of Surgical Pathology, Department of Pathology, University Hospital Zurich, 8091 Zurich, Switzerland
    J Clin Endocrinol Metab 92:1118-28. 2007
    ..To date, it is unknown whether small islet-like endocrine cell clusters found in MEN1 patients are neoplastic or rather hyperplastic. It is also unclear whether microadenomas develop from islets...
  14. ncbi Precursor lesions in patients with multiple endocrine neoplasia type 1-associated duodenal gastrinomas
    Martin Anlauf
    Department of Pathology, Univeristy of Kiel, Germany
    Gastroenterology 128:1187-98. 2005
    ..Precursor lesions may precede the development of duodenal gastrinomas because, in contrast to sporadic gastrinomas, these tumors are usually multiple...
  15. doi Primary lymph node gastrinoma or occult duodenal microgastrinoma with lymph node metastases in a MEN1 patient: the need for a systematic search for the primary tumor
    Martin Anlauf
    Department of Pathology, University of Kiel, Kiel, Germany
    Am J Surg Pathol 32:1101-5. 2008
    ..It is concluded that duodenal gastrinomas that give rise to lymph node metastases may be so tiny that they are easily overlooked in a routine examination and that systematic tissue monitoring is required to identify them...
  16. ncbi Increased expression of the E3-ubiquitin ligase receptor subunit betaTRCP1 relates to constitutive nuclear factor-kappaB activation and chemoresistance in pancreatic carcinoma cells
    Susanne Müerköster
    Laboratory of Molecular Gastroenterology and Hepatology, First Department of Medicine, Kiel University, UKSH Campus Kiel, Kiel, Germany
    Cancer Res 65:1316-24. 2005
    ..Altogether, our findings of the elevated betaTRCP1 expression in pancreatic carcinoma cells pinpoint to another important mediator of constitutive NF-kappaB activation and thereby of chemoresistance...
  17. ncbi Fibrogenesis in alcoholic chronic pancreatitis: the role of tissue necrosis, macrophages, myofibroblasts and cytokines
    Sönke Detlefsen
    Department of Pathology, University of Kiel, Germany
    Mod Pathol 19:1019-26. 2006
    ..The results suggest that the fibrogenic process in alcoholic chronic pancreatitis is initiated by a cytokine-based interplay of macrophages and myofibroblasts that follows tissue injury...
  18. doi Insulinomatosis: a multicentric insulinoma disease that frequently causes early recurrent hyperinsulinemic hypoglycemia
    Martin Anlauf
    Department of Pathology, University of Kiel, Kiel, Germany
    Am J Surg Pathol 33:339-46. 2009
    ..Multicentric insulinoma disease was characterized with regard to its histopathology, multiple endocrine neoplasia type 1 (MEN1) status, precursor lesions, and the risk of hyperinsulinemic hypoglycemia recurrence...
  19. ncbi Lymphatic spread of ductal pancreatic adenocarcinoma is independent of lymphangiogenesis
    Bence Sipos
    Department of Pathology, University of Kiel, Germany
    J Pathol 207:301-12. 2005
    ..The weak expression of lymphangiogenic cytokines in neoplastic cells and lymphatic vessel proliferation in peritumoural regions and chronic pancreatitis indicate that inflammation may be the reason for the low rate of lymphangiogenesis...
  20. ncbi Expression of transcription factors and precursor cell markers during regeneration of beta cells in pancreata of rats treated with streptozotocin
    Katharina Tiemann
    Department of Pathology, University of Kiel, Michaelisstr 11, 24105, Kiel, Germany
    Virchows Arch 450:261-6. 2007
    ..Ki-67 labeling was increased in islets on days 3 and 7. These results suggest that temporary upregulation of PDX-1 and prolonged overexpression of c-Kit may play a role during beta cell regeneration...
  21. ncbi Pancreatic fibrosis associated with age and ductal papillary hyperplasia
    Sönke Detlefsen
    Department of Pathology, University of Kiel, Michaelisstrasse 11, 24105, Kiel, Germany
    Virchows Arch 447:800-5. 2005
    ..The presence of myofibroblasts in association with the fibrotic foci indicates an ongoing fibrogenic process...
  22. ncbi Sporadic versus hereditary gastrinomas of the duodenum and pancreas: distinct clinico-pathological and epidemiological features
    Martin Anlauf
    Department of Pathology, University of Kiel, Michaelisstrasse 11, 24105 Kiel, Germany
    World J Gastroenterol 12:5440-6. 2006
    ..A considerable subset of tumors with immunohistochemical expression of gastrin but without evidence of ZES should be designated as functionally inactive NETs expressing gastrin, but not as gastrinomas...
  23. ncbi Hereditary neuroendocrine tumors of the gastroenteropancreatic system
    Martin Anlauf
    Department of Pathology, University of Kiel, Michaelisstr 11, 24105, Kiel, Germany
    Virchows Arch 451:S29-38. 2007
    ..In addition, GEP-NETs clustering in individual families or associated with other malignancies without known genetic background are discussed...
  24. ncbi Persistent hyperinsulinemic hypoglycemia in 15 adults with diffuse nesidioblastosis: diagnostic criteria, incidence, and characterization of beta-cell changes
    Martin Anlauf
    Department of Pathology, University of Kiel, Kiel, Germany
    Am J Surg Pathol 29:524-33. 2005
    ..As approximately 4% of adult patients with PHH are affected by diffuse nesidioblastosis, this disease is not as rare as it has been thought to be. Pathogenetically, the defective insulin secretion could be based on a molecular defect...
  25. ncbi Solid pseudopapillary neoplasms of the pancreas show an interruption of the Wnt-signaling pathway and express gene products of 11q
    Katharina Tiemann
    Department of Pathology, University of Kiel, Kiel, Germany
    Mod Pathol 20:955-60. 2007
    ..The accumulation of high expression of proteins whose genes are located on chromosome 11q is characteristic of solid pseudopapillary neoplasms, but not of pancreatic neuroendocrine tumors...
  26. ncbi Microadenomatosis of the endocrine pancreas in patients with and without the multiple endocrine neoplasia type 1 syndrome
    Martin Anlauf
    Departments of Pathology, University of Kiel, Michaelisstrasse 11, 24105 Kiel, Germany
    Am J Surg Pathol 30:560-74. 2006
    ..In addition, a monohormonal type of pancreatic microadenomatosis was identified that consisted of either insulinomas or glucagon-producing tumors and was not associated with MEN1 or VHL...
  27. ncbi The pathology of ductal-type pancreatic carcinomas and pancreatic intraepithelial neoplasia: insights for clinicians
    Gunter Kloppel
    Department of Pathology, University of Kiel, Michaelisstr 11, 24105 Kiel, Germany
    Curr Gastroenterol Rep 6:111-8. 2004
    ..Molecular studies have revealed that PanIN-2 and PanIN-3 lesions represent a distinct step toward invasive carcinoma...
  28. ncbi Epidemiology, tumour biology and histopathological classification of neuroendocrine tumours of the gastrointestinal tract
    Gunter Kloppel
    Department of Pathology, University Hospital of Kiel, Germany
    Best Pract Res Clin Gastroenterol 19:507-17. 2005
    ....
  29. ncbi Microcystic tubulopapillary carcinoma of the pancreas: a new tumor entity?
    Irene Esposito
    Department of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, 69120, Heidelberg, Germany
    Virchows Arch 444:447-53. 2004
    ..These data suggest that the neoplasm most likely represents a new pancreatic tumor entity, which we would like to refer to as microcystic tubulopapillary tumor...
  30. doi Autoimmune pancreatitis: expression and cellular source of profibrotic cytokines and their receptors
    Sönke Detlefsen
    Department of Pathology, University of Kiel, Kiel, Schleswig Holstein, Germany
    Am J Surg Pathol 32:986-95. 2008
    ..These cells and adjacent epithelial cells express profibrotic cytokines and their receptors, which are probably responsible for the initiation and maintenance of the fibrogenic process...
  31. ncbi Tumor stroma interactions induce chemoresistance in pancreatic ductal carcinoma cells involving increased secretion and paracrine effects of nitric oxide and interleukin-1beta
    Susanne Müerköster
    Laboratory of Molecular Gastroenterology and Hepatology, 1st Department of Medicine, UKSH Campus Kiel, Schittenhelmstrasse 12, 24105 Kiel, Germany
    Cancer Res 64:1331-7. 2004
    ..These findings substantiate the implication of tumor-stromal interactions in the chemoresistance of pancreatic carcinoma...
  32. ncbi Lack of apoptosis in PanIN-1 and PanIN-2 lesions associated with pancreatic ductal adenocarcinoma is not dependent on K-ras status
    Jutta Luttges
    Department of Pathology, University of Kiel, Kiel, Germany
    Pancreas 27:e57-62. 2003
    ..The question is addressed whether mutated K-ras interferes with the regulation of apoptosis or proliferation...
  33. ncbi Podocalyxin-like protein 1 expression is useful to differentiate pancreatic ductal adenocarcinomas from adenocarcinomas of the biliary and gastrointestinal tracts
    Jasmin Teresa Ney
    Institute of Pathology, University of Bonn, Bonn, Germany
    Hum Pathol 38:359-64. 2007
    ..Adenocarcinomas of the lung and prostate, and liver metastases of colorectal carcinomas lacked PODXL-1 expression. It is concluded that immunoreactivity for PODXL-1 favors a pancreatic origin if ampullary carcinoma is excluded...
  34. doi Glucagon cell adenomatosis: a newly recognized disease of the endocrine pancreas
    Tobias Henopp
    Department of Pathology, University of Tubingen, Liebermeisterstr 8, 72076 Tubingen, Germany
    J Clin Endocrinol Metab 94:213-7. 2009
    ..We observed a previously undescribed multicentric glucagon-producing tumor disease that is not related to MEN1...
  35. ncbi Endocrine precursor lesions and microadenomas of the duodenum and pancreas with and without MEN1: criteria, molecular concepts and clinical significance
    Martin Anlauf
    Department of Pathology, University of Kiel, Kiel, Germany
    Pathobiology 74:279-84. 2007
    ..Whether these types of microadenomatosis represent novel disease entities and how to diagnose and treat these patients remains to be clarified by further studies...
  36. doi Diagnosis of autoimmune pancreatitis by core needle biopsy: application of six microscopic criteria
    Sönke Detlefsen
    Department of Pathology, University Hospital Schleswig Holstein, Campus Kiel, Arnold Heller Str 3, Haus 14, 24105, Kiel, Germany
    Virchows Arch 454:531-9. 2009
    ..When the specimens that revealed only three features but showed GELs were added, the sensitivity rose to 86%. Pancreatic core needle biopsy can therefore make a significant contribution to the diagnosis of AIP...
  37. ncbi Pancreatic ductal adenocarcinomas with cystic features: neither rare nor uniform
    Markus Kosmahl
    Department of Pathology, University of Kiel, Germany
    Mod Pathol 18:1157-64. 2005
    ..Moreover, not all of the cystic structures we observed were neoplastic in nature. They may also represent non-neoplastic changes, such as retention cysts and inflammatory pseudocysts...
  38. doi ISL1 expression is not restricted to pancreatic well-differentiated neuroendocrine neoplasms, but is also commonly found in well and poorly differentiated neuroendocrine neoplasms of extrapancreatic origin
    Abbas Agaimy
    Institute of Pathology, University Hospital, Erlangen, Germany
    Mod Pathol 26:995-1003. 2013
    ..These findings modify the role of ISL1 as a marker for pancreatic neuroendocrine neoplasms and suggest that ISL1 has a broader involvement in differentiation and growth of neuroendocrine neoplasms than has so far been assumed. ..
  39. ncbi Serous cystic neoplasms of the pancreas: an immunohistochemical analysis revealing alpha-inhibin, neuron-specific enolase, and MUC6 as new markers
    Markus Kosmahl
    Department of Pathology, University of Kiel, Kiel, Germany
    Am J Surg Pathol 28:339-46. 2004
    ..Because a number of SCNs share MUC1 and MUC6 expression with the pancreatic centroacinar cells, the possibility of a histogenetic relationship has to be considered...
  40. doi Origin of pancreatic ductal adenocarcinoma from atypical flat lesions: a comparative study in transgenic mice and human tissues
    Michaela Aichler
    Institute of Pathology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    J Pathol 226:723-34. 2012
    ..In conclusion, PDAC development in Kras(G12D/+); Ptf1a-Cre(ex1/+) mice starts from ADM and a similar process might also take place in patients with a strong family history of PDAC...
  41. doi Squamous cell carcinoma of the penis: predicting nodal metastases by histologic grade, pattern of invasion and clinical examination
    Ibrahim Alkatout
    Department of Pathology, University Hospitals Schleswig Holstein, Campus Kiel, Kiel, Germany
    Urol Oncol 29:774-81. 2011
    ..These results revealed that the risk of inguinal lymph node metastasis in penile carcinoma can be predicted on the basis of 3 major factors: histologic grade, pattern of invasion, and clinical groin status...
  42. ncbi Solid pseudopapillary neoplasms of the pancreas are associated with FLI-1 expression, but not with EWS/FLI-1 translocation
    Katharina Tiemann
    Department of Pathology, University of Kiel, Kiel, Germany
    Mod Pathol 19:1409-13. 2006
    ..These data add another feature to the complex phenotypic appearance of solid pseudopapillary neoplasms...
  43. ncbi Autoimmune pancreatitis: pathological findings
    Gunter Kloppel
    Department of Pathology, University of Kiel, Kiel, Germany
    JOP 6:97-101. 2005
    ..Autoimmune pancreatitis most commonly involves the head of the pancreas and the distal bile duct. Occasionally, masses are formed and it has been described as an inflammatory myofibroblastic tumor...
  44. ncbi Foxp3 expression in pancreatic carcinoma cells as a novel mechanism of immune evasion in cancer
    Sebastian Hinz
    Division Molecular Oncology, Department for General Surgery, Institute of Immunology, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    Cancer Res 67:8344-50. 2007
    ..These findings indicate that pancreatic carcinoma cells share growth-suppressive effects with Treg and suggest that mimicking Treg function may represent a new mechanism of immune evasion in pancreatic cancer...
  45. doi Precancerous lesions of the biliary tree
    Gunter Kloppel
    Department of Pathology, TU Munich, Ismaningerstraße 22, 81675 Munchen, Germany
    Best Pract Res Clin Gastroenterol 27:285-97. 2013
    ..This review discusses the pathological, molecular, epidemiological, clinical and prognostic features of the precancerous biliary lesions, separated according to their origin in the bile ducts, the ampulla and the gall bladder. ..
  46. ncbi Where and when does pancreatic carcinoma start?
    Jutta Luttges
    Department of Pathology, University of Kiel, Germany
    Med Klin (Munich) 99:191-5. 2004
    ..Molecular studies revealed that PanIN-2 and PanIN-3 lesions represent a distinct step toward invasive carcinoma...
  47. ncbi Elevated L1CAM expression in precursor lesions and primary and metastastic tissues of pancreatic ductal adenocarcinoma
    Frank Bergmann
    Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    Oncol Rep 24:909-15. 2010
    ..Furthermore, its broad expression in primary tumors as well as in metastases of PDAC patients provide a rationale to further explore the value of L1CAM as a therapeutic target in the treatment of this highly malignant tumor...
  48. ncbi Autoimmune pancreatitis: histo- and immunopathological features
    Gunter Kloppel
    Department of Pathology, University of Kiel, Michaelisstr, 11, 24105, Kiel, Germany
    J Gastroenterol 42:28-31. 2007
    ..Occasionally it is mass-forming, and has been described as an inflammatory myofibroblastic tumor. The presence of more than 20 IgG4-positive plasma cells per high-power field is of high specificity for the tissue diagnosis of AIP...
  49. doi Deposition of complement C3c, immunoglobulin (Ig)G4 and IgG at the basement membrane of pancreatic ducts and acini in autoimmune pancreatitis
    Sönke Detlefsen
    Department of Pathology, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    Histopathology 57:825-35. 2010
    ..The aim was to investigate the deposition of complement and immunoglobulins in pancreatic tissue from AIP patients compared to non-AIP patients...
  50. ncbi Pancreatic solid and cystic hamartoma in adults: characterization of a new tumorous lesion
    Ursula Pauser
    Department of Pathology, University of Kiel, Michaelisstrasse 11, 24105 Kiel, Germany
    Am J Surg Pathol 29:797-800. 2005
    ..Because of the irregular arrangement of otherwise mature tissue components of the pancreas, the lesions were considered solid and cystic hamartomas. Their pathogenesis is so far unknown...
  51. ncbi A comprehensive characterization of pancreatic ductal carcinoma cell lines: towards the establishment of an in vitro research platform
    Bence Sipos
    Department of Pathology, University of Kiel, Germany
    Virchows Arch 442:444-52. 2003
    ..We conclude that the proposed ultrastructural grading system combined with the proliferative activity provides a basis for further comparative studies of pancreatic ductal adenocarcinoma cell lines...
  52. ncbi Autoimmune pancreatitis: frequency, IgG4 expression, and clonality of T and B cells
    Motohiro Kojima
    Department of Pathology, University of Kiel, Germany
    Am J Surg Pathol 31:521-8. 2007
    ..High density infiltrates of IgG4 positive plasma cells are diagnostic for AIP, but are seen in less than half of the cases. T or B-cell oligoclonality could not be established as a feature of AIP...
  53. pmc Expression of lymphangiogenic factors and evidence of intratumoral lymphangiogenesis in pancreatic endocrine tumors
    Bence Sipos
    Department of Pathology, University of Kiel, Michaelisstr 11, 24105 Kiel, Germany
    Am J Pathol 165:1187-97. 2004
    ..PET is the first human tumor entity in which VEGF-C-related intratumoral lymphangiogenesis has been demonstrated...
  54. ncbi Pancreatic mucinous noncystic (colloid) carcinomas and intraductal papillary mucinous carcinomas are usually microsatellite stable
    Jutta Luttges
    Department of Pathology, University of Kiel, Germany
    Mod Pathol 16:537-42. 2003
    ..The data suggest that pancreatic carcinomas with a mucinous phenotype (MUC2+/MUC1-) do not appear to normally exhibit mutations in the mismatch repair genes and therefore differ in their carcinogenesis from those in other organs...
  55. ncbi How do gastric carcinoma classification systems relate to mucin expression patterns? An immunohistochemical analysis in a series of advanced gastric carcinomas
    Yesim Gurbuz
    Department of Pathology, University of Kiel, Michaelisstrasse 11, 24105 Kiel, Germany
    Virchows Arch 440:505-11. 2002
    ..It is likely that each of these gastric carcinoma types has its own carcinogenesis...
  56. doi Lack of CCR7 expression is rate limiting for lymphatic spread of pancreatic ductal adenocarcinoma
    Jan Sperveslage
    Institute of Pathology, University of Tubingen, Tubingen, Germany
    Int J Cancer 131:E371-81. 2012
    ..Lymph vessel invasion by CCR7 expressing PDAC cells may be additionally enhanced by upregulation of CCL21 in tumor-associated lymph vessels, representing a previously unknown factor of lymphatic spread...
  57. doi Lymph-node metastases in intermediate-risk squamous cell carcinoma of the penis
    Carsten M Naumann
    Department of Urology and Paediatric Urology, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    BJU Int 102:1102-6. 2008
    ..To evaluate the metastatic risk of pT1 G2 squamous cell carcinoma (SCC) of the penis...
  58. doi Autoimmune pancreatitis: the clinicopathological characteristics of the subtype with granulocytic epithelial lesions
    Gunter Kloppel
    Department of Pathology, Technical University of Munich, Ismaninger Str 22, 81675 Munich, Germany
    J Gastroenterol 45:787-93. 2010
    ..This article reviews the evidence that GEL-positive AIP or IDCP is a second type of AIP, distinct from LPSP, in regard to pancreatic pathology, immunology and epidemiology...
  59. pmc P53 expression is significantly correlated with high risk of malignancy and epithelioid differentiation in GISTs. An immunohistochemical study of 104 cases
    Ursula Pauser
    Department of Pathology, University of Lubeck, Germany
    BMC Cancer 8:204. 2008
    ..The aim of our study was to evaluate cell cycle regulators as potential prognostic markers in GISTs...
  60. ncbi Mucinous nonneoplastic cyst of the pancreas: a novel nonneoplastic cystic change?
    Markus Kosmahl
    Department of Pathology, University of Kiel, Kiel, Germany
    Mod Pathol 15:154-8. 2002
    ..Because they may represent a nonneoplastic cystic change of the pancreas, we propose the descriptive term mucinous nonneoplastic cyst for these tumors of unknown pathogenesis...
  61. doi Classification and pathology of gastroenteropancreatic neuroendocrine neoplasms
    Gunter Kloppel
    Department of Pathology, Technical University of München, Ismaninger Strasse 22, 81675 Munchen, Germany
    Endocr Relat Cancer 18:S1-16. 2011
    ..In the light of these criteria the pathology and biology of the various NETs and NECs of the gastrointestinal tract (including the oesophagus) and the pancreas are reviewed...
  62. doi Glucagon expression in cystic pancreatic neuroendocrine neoplasms: an immunohistochemical analysis
    Björn Konukiewitz
    Department of Pathology, University of Kiel, Kiel, Germany
    Virchows Arch 458:47-53. 2011
    ..Solitary non-MEN1-associated and MEN1-associated cystic P-NENs are predominantly non-syndromic glucagon-expressing tumors. However, cystic insulinomas may also occur. Cyst formation seems to be related to hormone production...
  63. ncbi Clinicopathological significance and molecular regulation of maspin expression in ductal adenocarcinoma of the pancreas
    Nobuyuki Ohike
    Department of Pathology, University of Kiel, Kiel, Germany
    Cancer Lett 199:193-200. 2003
    ....
  64. ncbi The gastroenteropancreatic neuroendocrine cell system and its tumors: the WHO classification
    Gunter Kloppel
    Department of General Pathology, University of Kiel, Kiel, Germany
    Ann N Y Acad Sci 1014:13-27. 2004
    ..On the basis of localization and of various morphological and biological criteria, we distinguish between benign neuroendocrine tumors, tumors with uncertain malignant potential, and tumors showing low-grade and high-grade malignancy...
  65. ncbi Chronic pancreatitis, pseudotumors and other tumor-like lesions
    Gunter Kloppel
    Department of Pathology, University of Kiel, Kiel, Schleswig Holstein, Germany
    Mod Pathol 20:S113-31. 2007
    ..This review describes and discusses the main histological findings, the pathogenesis and the clinical features of the various types of chronic pancreatitis. In addition, pseudotumors and other tumor-like lesions are briefly mentioned...
  66. ncbi Rare ductal adenocarcinoma of the pancreas in patients younger than age 40 years
    Jutta Luttges
    Department of Pathology, University of Kiel, Kiel, Germany
    Cancer 100:173-82. 2004
    ..The objective of the current study was to determine whether the features of PDACs in patients age < 40 years differ from those in older patients. The authors reviewed the literature and their own files...
  67. doi Interobserver variation in grading and staging of squamous cell carcinoma of the penis in relation to the clinical outcome
    Carsten M Naumann
    Department of Urology and Paediatric Urology, University Hospital Schleswig Holstein, Campus Kiel, Arnold Heller Str 7, D 24105 Kiel, Germany
    BJU Int 103:1660-5. 2009
    ..To examine interobserver variations in assessing grade and stage of penile squamous cell carcinoma (SCC)...
  68. ncbi Gastrointestinal mesenchymal tumors - immunophenotypic classification and survival analysis
    Pierre Rudolph
    Department of Pathology, University of Kiel, Michaelisstr 11, 24105 Kiel, Germany
    Virchows Arch 441:238-48. 2002
    ..We conclude that, despite strong morphological similarities, gastrointestinal mesenchymal tumors are heterogeneous in their immunophenotype and biology...
  69. ncbi Chronic sclerosing sialadenitis of the submandibular gland is mainly due to a T lymphocyte immune reaction
    Markus Tiemann
    Department of Hematopathology, University of Kiel, Germany
    Mod Pathol 15:845-52. 2002
    ....
  70. ncbi Chronic pancreatitis of alcoholic and nonalcoholic origin
    Gunter Kloppel
    Department of Pathology, University of Kiel, Kiel, Germany
    Semin Diagn Pathol 21:227-36. 2004
    ..In addition, brief descriptions of the features of chronic pancreatitis of nonalcoholic origin and of the pancreatic fibrosis that is not associated with symptoms of chronic pancreatitis will be given...
  71. ncbi Vascular endothelial growth factor mediated angiogenic potential of pancreatic ductal carcinomas enhanced by hypoxia: an in vitro and in vivo study
    Bence Sipos
    Department of Pathology, University of Kiel, Kiel, Germany
    Int J Cancer 102:592-600. 2002
    ..Surprisingly, perinecrotic tumor areas, which are supposed to be hypoxic, only rarely showed the expected increase in microvessel density and VEGF expression...
  72. ncbi Expression of stem cell markers and transcription factors during the remodeling of the rat pancreas after duct ligation
    Katharina Peters
    Department of Pathology, University of Kiel, Kiel, Germany
    Virchows Arch 446:56-63. 2005
    ..The findings indicate that the stem cell markers c-Kit and nestin as well as the transcription factors Pdx1 and Nkx2.2 are upregulated in compartments of the pancreas that are involved in islet cell neogenesis after duct ligation...
  73. ncbi Vesicular monoamine transporter 2 (VMAT2) expression in hematopoietic cells and in patients with systemic mastocytosis
    Martin Anlauf
    Department of Pathology, University of Kiel, Michaelisstr 11, 24105 Kiel, Germany
    J Histochem Cytochem 54:201-13. 2006
    ....
  74. ncbi Autoimmune pancreatitis: pathological, clinical, and immunological features
    Gunter Kloppel
    Department of Pathology, University of Kiel, Kiel, Germany
    Pancreas 27:14-9. 2003
    ..Hence, the term autoimmune pancreatitis has been introduced and will be used in this review...
  75. doi Extraabdominal malposition of the gallbladder
    Ibrahim Alkatout
    Department of General and Thoracic Surgery, Division of Pediatric Surgery, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    J Pediatr Surg 43:e41-4. 2008
    ....
  76. ncbi Acute pancreatitis
    Gunter Kloppel
    Department of Pathology, University of Kiel, Kiel, Germany
    Semin Diagn Pathol 21:221-6. 2004
    ..The acinar type of necrosis is caused by infectious agents. Complications of acute pancreatitis, such as pseudocyst, bleeding, and infection, determine the course of the disease...
  77. ncbi Fibrosis of the pancreas: the initial tissue damage and the resulting pattern
    Gunter Kloppel
    Department of Pathology, University of Kiel, Michaelisstrasse 11, 24105, Kiel, Germany
    Virchows Arch 445:1-8. 2004
    ....
  78. ncbi Cellular hamartoma resembling gastrointestinal stromal tumor: a solid tumor of the pancreas expressing c-kit (CD117)
    Ursula Pauser
    Department of Pathology, University of Kiel, Germany
    Mod Pathol 18:1211-6. 2005
    ..The follow-up (2 and 4 years) of the patients was uneventful. We propose to designate the tumors as 'cellular hamartoma resembling gastrointestinal stromal tumor...
  79. ncbi Neuroendocrine carcinomas of the prostate and urinary bladder: a diagnostic and therapeutic challenge
    Burkhard Helpap
    Department of Pathology, Academic Hospital of the University of Freiburg, Postfach 720, 78207 Singen, Germany
    Virchows Arch 440:241-8. 2002
    ..In the case of high-grade neuroendocrine carcinomas, early diagnosis and initiation of appropriate chemotherapy may increase survival and potentially induce complete remission in individual cases...