G Kloppel

Summary

Affiliation: University of Kiel
Country: Germany

Publications

  1. ncbi Microcystic tubulopapillary carcinoma of the pancreas: a new tumor entity?
    Irene Esposito
    Department of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, 69120, Heidelberg, Germany
    Virchows Arch 444:447-53. 2004
  2. ncbi The gastroenteropancreatic neuroendocrine cell system and its tumors: the WHO classification
    Gunter Kloppel
    Department of General Pathology, University of Kiel, Kiel, Germany
    Ann N Y Acad Sci 1014:13-27. 2004
  3. pmc P53 expression is significantly correlated with high risk of malignancy and epithelioid differentiation in GISTs. An immunohistochemical study of 104 cases
    Ursula Pauser
    Department of Pathology, University of Lubeck, Germany
    BMC Cancer 8:204. 2008
  4. ncbi Pseudocysts and other non-neoplastic cysts of the pancreas
    G Kloppel
    Department of Pathology, University of Kiel, Germany
    Semin Diagn Pathol 17:7-15. 2000
  5. ncbi The pathology of ductal-type pancreatic carcinomas and pancreatic intraepithelial neoplasia: insights for clinicians
    Gunter Kloppel
    Department of Pathology, University of Kiel, Michaelisstr 11, 24105 Kiel, Germany
    Curr Gastroenterol Rep 6:111-8. 2004
  6. ncbi Chronic pancreatitis of alcoholic and nonalcoholic origin
    Gunter Kloppel
    Department of Pathology, University of Kiel, Kiel, Germany
    Semin Diagn Pathol 21:227-36. 2004
  7. ncbi Fibrosis of the pancreas: the initial tissue damage and the resulting pattern
    Gunter Kloppel
    Department of Pathology, University of Kiel, Michaelisstrasse 11, 24105, Kiel, Germany
    Virchows Arch 445:1-8. 2004
  8. ncbi Cystic lesions and neoplasms of the pancreas. The features are becoming clearer
    G Kloppel
    Department of Pathology, University of Kiel, Michaelisstrasse 11, D 24105 Kiel, Germany
    Pancreatology 1:648-55. 2001
  9. ncbi Acute pancreatitis
    Gunter Kloppel
    Department of Pathology, University of Kiel, Kiel, Germany
    Semin Diagn Pathol 21:221-6. 2004
  10. ncbi Epidemiology, tumour biology and histopathological classification of neuroendocrine tumours of the gastrointestinal tract
    Gunter Kloppel
    Department of Pathology, University Hospital of Kiel, Germany
    Best Pract Res Clin Gastroenterol 19:507-17. 2005

Collaborators

Detail Information

Publications99

  1. ncbi Microcystic tubulopapillary carcinoma of the pancreas: a new tumor entity?
    Irene Esposito
    Department of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, 69120, Heidelberg, Germany
    Virchows Arch 444:447-53. 2004
    ..These data suggest that the neoplasm most likely represents a new pancreatic tumor entity, which we would like to refer to as microcystic tubulopapillary tumor...
  2. ncbi The gastroenteropancreatic neuroendocrine cell system and its tumors: the WHO classification
    Gunter Kloppel
    Department of General Pathology, University of Kiel, Kiel, Germany
    Ann N Y Acad Sci 1014:13-27. 2004
    ..On the basis of localization and of various morphological and biological criteria, we distinguish between benign neuroendocrine tumors, tumors with uncertain malignant potential, and tumors showing low-grade and high-grade malignancy...
  3. pmc P53 expression is significantly correlated with high risk of malignancy and epithelioid differentiation in GISTs. An immunohistochemical study of 104 cases
    Ursula Pauser
    Department of Pathology, University of Lubeck, Germany
    BMC Cancer 8:204. 2008
    ..The aim of our study was to evaluate cell cycle regulators as potential prognostic markers in GISTs...
  4. ncbi Pseudocysts and other non-neoplastic cysts of the pancreas
    G Kloppel
    Department of Pathology, University of Kiel, Germany
    Semin Diagn Pathol 17:7-15. 2000
    ....
  5. ncbi The pathology of ductal-type pancreatic carcinomas and pancreatic intraepithelial neoplasia: insights for clinicians
    Gunter Kloppel
    Department of Pathology, University of Kiel, Michaelisstr 11, 24105 Kiel, Germany
    Curr Gastroenterol Rep 6:111-8. 2004
    ..Molecular studies have revealed that PanIN-2 and PanIN-3 lesions represent a distinct step toward invasive carcinoma...
  6. ncbi Chronic pancreatitis of alcoholic and nonalcoholic origin
    Gunter Kloppel
    Department of Pathology, University of Kiel, Kiel, Germany
    Semin Diagn Pathol 21:227-36. 2004
    ..In addition, brief descriptions of the features of chronic pancreatitis of nonalcoholic origin and of the pancreatic fibrosis that is not associated with symptoms of chronic pancreatitis will be given...
  7. ncbi Fibrosis of the pancreas: the initial tissue damage and the resulting pattern
    Gunter Kloppel
    Department of Pathology, University of Kiel, Michaelisstrasse 11, 24105, Kiel, Germany
    Virchows Arch 445:1-8. 2004
    ....
  8. ncbi Cystic lesions and neoplasms of the pancreas. The features are becoming clearer
    G Kloppel
    Department of Pathology, University of Kiel, Michaelisstrasse 11, D 24105 Kiel, Germany
    Pancreatology 1:648-55. 2001
    ..The progress made in recent years has made it possible to clearly distinguish between the various entities and to unravel some of the problems involved...
  9. ncbi Acute pancreatitis
    Gunter Kloppel
    Department of Pathology, University of Kiel, Kiel, Germany
    Semin Diagn Pathol 21:221-6. 2004
    ..The acinar type of necrosis is caused by infectious agents. Complications of acute pancreatitis, such as pseudocyst, bleeding, and infection, determine the course of the disease...
  10. ncbi Epidemiology, tumour biology and histopathological classification of neuroendocrine tumours of the gastrointestinal tract
    Gunter Kloppel
    Department of Pathology, University Hospital of Kiel, Germany
    Best Pract Res Clin Gastroenterol 19:507-17. 2005
    ....
  11. ncbi Autoimmune pancreatitis: pathological, clinical, and immunological features
    Gunter Kloppel
    Department of Pathology, University of Kiel, Kiel, Germany
    Pancreas 27:14-9. 2003
    ..Hence, the term autoimmune pancreatitis has been introduced and will be used in this review...
  12. ncbi [Neuroendocrine tumors of the gastrointestinal tract]
    G Kloppel
    Institut für allgemeine Pathologie und pathologische Anatomie, Universitatsklinikum Schleswig Holstein, Kiel
    Pathologe 24:287-96. 2003
    ..This system allows a clinically relevant diagnosis and includes all so far known tumor entities...
  13. ncbi Chronic pancreatitis, pseudotumors and other tumor-like lesions
    Gunter Kloppel
    Department of Pathology, University of Kiel, Kiel, Schleswig Holstein, Germany
    Mod Pathol 20:S113-31. 2007
    ..This review describes and discusses the main histological findings, the pathogenesis and the clinical features of the various types of chronic pancreatitis. In addition, pseudotumors and other tumor-like lesions are briefly mentioned...
  14. ncbi [Tumors of the adrenal medulla and the paraganglia]
    G Kloppel
    Institut für allgemeine Pathologie und pathologische Anatomie, Universitatsklinikum Schleswig Holstein, Campus Kiel, Kiel
    Pathologe 24:280-6. 2003
    ..The parasympathetic paragangliomas are usually benign, hormonally inactive and are most commonly located in the bifurcation of the carotid artery...
  15. ncbi [Spectrum of chronic pancreatitis. On the way to etiological classification]
    G Kloppel
    Institut für Allgemeine Pathologie, Universitätsklinikum Schleswig Holstein Campus Kiel, Michaelisstrasse 11, 24105 Kiel, Germany
    Pathologe 26:59-66. 2005
    ..A catalog of five criteria is presented for distinguishing chronic pancreatitis from ductal adenocarcinoma of the pancreas...
  16. ncbi [Intraductal neoplasms of the pancreas: cystic and common]
    G Kloppel
    Institut für Allgemeine Pathologie, Universitätsklinikum Schleswig Holstein Campus Kiel, Michaelisstrasse 11, 24105 Kiel, Germany
    Pathologe 26:31-6. 2005
    ..Currently, IPMNs have advanced to the most commonly resected cystic tumor of the pancreas. Recent studies have shown that IPMNs may be distinguished into different types showing a different biology according to their mucin pattern...
  17. ncbi Clinicopathologic view of intraductal papillary-mucinous tumor of the pancreas
    G Kloppel
    Department of Pathology, University of Kiel, Germany
    Hepatogastroenterology 45:1981-5. 1998
    ..In patients with invasive and metastatic IPMT, survival ranges from a few months up to 3 years...
  18. ncbi Autoimmune pancreatitis: pathological findings
    Gunter Kloppel
    Department of Pathology, University of Kiel, Kiel, Germany
    JOP 6:97-101. 2005
    ..Autoimmune pancreatitis most commonly involves the head of the pancreas and the distal bile duct. Occasionally, masses are formed and it has been described as an inflammatory myofibroblastic tumor...
  19. ncbi [Tumors of the endocrine pancreas]
    G Kloppel
    Institut für allgemeine Pathologie und pathologische Anatomie, Universitatsklinikum Schleswig Holstein, Campus Kiel
    Pathologe 24:265-71. 2003
    ..The functional tumor entities on which the classification is based are briefly described and discussed...
  20. ncbi Progression from acute to chronic pancreatitis. A pathologist's view
    G Kloppel
    Department of Pathology, University of Kiel, Germany
    Surg Clin North Am 79:801-14. 1999
    ..How alcohol abuse triggers pancreatic injury and which factors are responsible for the progression to chronic pancreatitis remain to be clarified, however...
  21. ncbi The immunohistochemical mucin expression pattern distinguishes different types of intraductal papillary mucinous neoplasms of the pancreas and determines their relationship to mucinous noncystic carcinoma and ductal adenocarcinoma
    J Luttges
    Department of Pathology, University of Kiel, Germany
    Am J Surg Pathol 25:942-8. 2001
    ..The second group seems to be related to ductal carcinoma because of its MUC1 positivity in the absence or very weak MUC2 staining. The third group shows focal MUC1/MUC2 expression and is characterized by oncocytic histology...
  22. ncbi The grade of pancreatic ductal carcinoma is an independent prognostic factor and is superior to the immunohistochemical assessment of proliferation
    J Luttges
    Department of Pathology, University of Kiel, Germany
    J Pathol 191:154-61. 2000
    ..Criteria that relate to cellular and structural differentiation seem to be more predictive than those related to proliferation...
  23. ncbi [Cystic pancreas tumors and their classification: features old and new]
    M Kosmahl
    Institut für Allgemeine Pathologie, Universitätsklinikum Schleswig Holstein Campus Kiel, Michaelisstrasse 11, 24105 Kiel, Germany
    Pathologe 26:22-30. 2005
    ..This review discusses the most important cystic tumors and tumor-like lesions, presents a new classification, and summarizes the immunohistochemical differential diagnosis...
  24. ncbi Fibrogenesis in alcoholic chronic pancreatitis: the role of tissue necrosis, macrophages, myofibroblasts and cytokines
    Sönke Detlefsen
    Department of Pathology, University of Kiel, Germany
    Mod Pathol 19:1019-26. 2006
    ..The results suggest that the fibrogenic process in alcoholic chronic pancreatitis is initiated by a cytokine-based interplay of macrophages and myofibroblasts that follows tissue injury...
  25. ncbi Duct changes and K-ras mutations in the disease-free pancreas: analysis of type, age relation and spatial distribution
    J Luttges
    Department of Pathology, University of Kiel, Michaelisstrasse 11, D 24105 Kiel, Germany
    Virchows Arch 435:461-8. 1999
    ..Hyperplastic/metaplastic duct changes of the pancreas increase with age, but their distribution pattern in the pancreas differs from that of ductal carcinomas...
  26. ncbi [Solid pseudopapillary neoplasms. Enigmatic entity with female preponderance]
    M Kosmahl
    Institut für Allgemeine Pathologie, Universitätsklinikum Schleswig Holstein Campus Kiel, Michaelisstrasse 11, 24105 Kiel, Germany
    Pathologe 26:41-5. 2005
    ..Predicting malignancy histologically is not yet possible. The most important differential diagnosis to consider is neuroendocrine tumor of the pancreas. The etiology and pathogenesis of SPN are obscure...
  27. ncbi Pancreatic fibrosis associated with age and ductal papillary hyperplasia
    Sönke Detlefsen
    Department of Pathology, University of Kiel, Michaelisstrasse 11, 24105, Kiel, Germany
    Virchows Arch 447:800-5. 2005
    ..The presence of myofibroblasts in association with the fibrotic foci indicates an ongoing fibrogenic process...
  28. doi Diagnosis of autoimmune pancreatitis by core needle biopsy: application of six microscopic criteria
    Sönke Detlefsen
    Department of Pathology, University Hospital Schleswig Holstein, Campus Kiel, Arnold Heller Str 3, Haus 14, 24105, Kiel, Germany
    Virchows Arch 454:531-9. 2009
    ..When the specimens that revealed only three features but showed GELs were added, the sensitivity rose to 86%. Pancreatic core needle biopsy can therefore make a significant contribution to the diagnosis of AIP...
  29. doi Autoimmune pancreatitis: expression and cellular source of profibrotic cytokines and their receptors
    Sönke Detlefsen
    Department of Pathology, University of Kiel, Kiel, Schleswig Holstein, Germany
    Am J Surg Pathol 32:986-95. 2008
    ..These cells and adjacent epithelial cells express profibrotic cytokines and their receptors, which are probably responsible for the initiation and maintenance of the fibrogenic process...
  30. ncbi Recommendation for the examination of pancreaticoduodenectomy specimens removed from patients with carcinoma of the exocrine pancreas. A proposal for a standardized pathological staging of pancreaticoduodenectomy specimens including a checklist
    J Luttges
    Department of Pathology, University of Kiel, Germany
    Dig Surg 16:291-6. 1999
    ....
  31. pmc Allelic loss is often the first hit in the biallelic inactivation of the p53 and DPC4 genes during pancreatic carcinogenesis
    J Luttges
    Departments of Pathology and Surgery, University of Kiel, Kiel University of Bochum, Bochum, Germany
    Am J Pathol 158:1677-83. 2001
    ....
  32. ncbi Update on the pathology and genetics of exocrine pancreatic tumors with ductal phenotype: precursor lesions and new tumor entities
    J Luttges
    Department of Pathology, University of Kiel, Germany
    Dig Dis 19:15-23. 2001
    ....
  33. ncbi [Mesenchymal tumors of the pancreas. Surprising, but not uncommon]
    U Pauser
    Institut für Allgemeine Pathologie, Universitätsklinikum Schleswig Holstein Campus Kiel, Michaelisstrasse 11, 24105 Kiel, Germany
    Pathologe 26:52-8. 2005
    ..It is important to differentiate these tumors from anaplastic carcinomas and retroperitoneal tumors that infiltrate pancreatic tissue...
  34. ncbi [Pancreatic ductal adenocarcinoma and its precursors]
    J Luttges
    Institut für Allgemeine Pathologie, Universitätsklinikum Schleswig Holstein Campus Kiel, Michaelisstrasse 11, 24105 Kiel, Germany
    Pathologe 26:12-7. 2005
    ..With the definition of ductal lesions as pancreatic intraepithelial neoplasia, a progression model for pancreatic ductal carcinoma has been developed and corresponding gene alterations have been detected...
  35. ncbi Clinicopathological significance and molecular regulation of maspin expression in ductal adenocarcinoma of the pancreas
    Nobuyuki Ohike
    Department of Pathology, University of Kiel, Kiel, Germany
    Cancer Lett 199:193-200. 2003
    ....
  36. ncbi [Tumors of the endocrine pancreas]
    M Anlauf
    Institut für Allgemeine Pathologie, Universitätsklinikum Schleswig Holstein Campus Kiel, Michaelisstrasse 11, 24105 Kiel, Germany
    Pathologe 26:46-51. 2005
    ..In recent years the percentage of non-functional tumors has increased...
  37. ncbi [Undifferentiated pancreatic carcinomas. Leap into chaos]
    K Peters
    Institut für Allgemeine Pathologie, Universitätsklinikum Schleswig Holstein Campus Kiel, Michaelisstrasse 11, 24105 Kiel, Germany
    Pathologe 26:18-21. 2005
    ..An uncommon variant is undifferentiated pancreatic carcinoma with osteoclast-like giant cells. This variant can be associated with mucinous cystic neoplasms and is characterized by abundant non-neoplastic osteoclast-like giant cells...
  38. ncbi Drug-induced expression of the cellular adhesion molecule L1CAM confers anti-apoptotic protection and chemoresistance in pancreatic ductal adenocarcinoma cells
    S Sebens Müerköster
    Clinic of Internal Medicine, Laboratory of Molecular Gastroenterology and Hepatology, UKSH Campus Kiel, Kiel, Germany
    Oncogene 26:2759-68. 2007
    ..These findings substantiate our understanding of the molecular mechanisms leading to chemoresistance in PDAC cells and indicate the importance of L1CAM in this scenario...
  39. ncbi Cystic neoplasms of the pancreas and tumor-like lesions with cystic features: a review of 418 cases and a classification proposal
    M Kosmahl
    Department of Pathology, University of Kiel, Germany
    Virchows Arch 445:168-78. 2004
    ..This classification is easy to handle and enables a distinction on the basis of clinical behavior and prognosis...
  40. ncbi [Acinar cell carcinomas and pancreatoblastomas: related but not the same]
    B Sipos
    Institut für Allgemeine Pathologie, Universitätsklinikum Schleswig Holstein Campus Kiel, Michaelisstrasse 11, 24105 Kiel, Germany
    Pathologe 26:37-40. 2005
    ..Both tumor types commonly show allelic losses on chromosome 11p and mutations in the APC/beta-catenin signaling pathway. Pancreatoblastomas, in contrast to acinar cell carcinomas, are potentially curable...
  41. ncbi Immunohistochemical screening for beta6-integrin subunit expression in adenocarcinomas using a novel monoclonal antibody reveals strong up-regulation in pancreatic ductal adenocarcinomas in vivo and in vitro
    B Sipos
    Department of Pathology, University of Kiel, Germany
    Histopathology 45:226-36. 2004
    ..To analyse the expression of alphavbeta6, an epithelial integrin involved in wound healing and tumorigenesis, in various human carcinoma types...
  42. doi Pancreatic intraepithelial neoplasia revisited and updated
    B Sipos
    Department of Pathology, University of Kiel, Kiel, Germany
    Pancreatology 9:45-54. 2009
    ..Global gene expression analysis identified several differentially expressed genes which show enhanced expression in PanINs and may be used as potential biomarkers to facilitate diagnosis and therapy...
  43. ncbi Pancreatic tumours with cystic features
    M Kosmahl
    Department of Pathology, University of Kiel
    Cesk Patol 39:155-62. 2003
  44. ncbi Expression of the tumor suppressor gene Maspin in human pancreatic cancers
    N Maass
    Department of Gynecologic Oncology, University of Kiel, 24105 Kiel, Germany
    Clin Cancer Res 7:812-7. 2001
    ..In addition, the detection of maspin in pancreatic tumor tissues and its lack of expression in all normal pancreatic tissues suggests that maspin may be a useful marker of primary human pancreatic cancer...
  45. ncbi Solitary fibrous tumour of the pancreas: a new member of the small group of mesenchymal pancreatic tumours
    J Luttges
    Department of Pathology, University of Kiel, Germany
    Virchows Arch 435:37-42. 1999
    ..Other mesenchymal tumours that may occur in the pancreas include tumours of the peripheral nerve sheath, fibrous histiocytic tumours and rare vascular tumours...
  46. doi [Neuroendocrine tumors of the stomach. Risk stratification and therapy]
    G Kloppel
    Institut fur Pathologie, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaningerstr 22, 81675 Munchen
    Pathologe 31:182-7. 2010
    ..With exact diagnosis and adequate treatment, the majority of patients with gastric NETs have a favorable prognosis...
  47. ncbi Solid pseudopapillary neoplasms of the pancreas show an interruption of the Wnt-signaling pathway and express gene products of 11q
    Katharina Tiemann
    Department of Pathology, University of Kiel, Kiel, Germany
    Mod Pathol 20:955-60. 2007
    ..The accumulation of high expression of proteins whose genes are located on chromosome 11q is characteristic of solid pseudopapillary neoplasms, but not of pancreatic neuroendocrine tumors...
  48. ncbi Tumour biology and histopathology of neuroendocrine tumours
    Gunter Kloppel
    Department of Pathology, University of Kiel, Michaelisstr 11, 24105 Kiel, Germany
    Best Pract Res Clin Endocrinol Metab 21:15-31. 2007
    ..Their clinical behaviour--ranging from benign and low-grade to high-grade malignancy--can be predicted on the basis of clinicopathological criteria. Currently extensive work is being performed to unravel the genetic background...
  49. ncbi Solid pseudopapillary neoplasms of the pancreas are associated with FLI-1 expression, but not with EWS/FLI-1 translocation
    Katharina Tiemann
    Department of Pathology, University of Kiel, Kiel, Germany
    Mod Pathol 19:1409-13. 2006
    ..These data add another feature to the complex phenotypic appearance of solid pseudopapillary neoplasms...
  50. ncbi Expression of transcription factors and precursor cell markers during regeneration of beta cells in pancreata of rats treated with streptozotocin
    Katharina Tiemann
    Department of Pathology, University of Kiel, Michaelisstr 11, 24105, Kiel, Germany
    Virchows Arch 450:261-6. 2007
    ..Ki-67 labeling was increased in islets on days 3 and 7. These results suggest that temporary upregulation of PDX-1 and prolonged overexpression of c-Kit may play a role during beta cell regeneration...
  51. ncbi Microadenomatosis of the endocrine pancreas in patients with and without the multiple endocrine neoplasia type 1 syndrome
    Martin Anlauf
    Departments of Pathology, University of Kiel, Michaelisstrasse 11, 24105 Kiel, Germany
    Am J Surg Pathol 30:560-74. 2006
    ..In addition, a monohormonal type of pancreatic microadenomatosis was identified that consisted of either insulinomas or glucagon-producing tumors and was not associated with MEN1 or VHL...
  52. ncbi Foxp3 expression in pancreatic carcinoma cells as a novel mechanism of immune evasion in cancer
    Sebastian Hinz
    Division Molecular Oncology, Department for General Surgery, Institute of Immunology, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    Cancer Res 67:8344-50. 2007
    ..These findings indicate that pancreatic carcinoma cells share growth-suppressive effects with Treg and suggest that mimicking Treg function may represent a new mechanism of immune evasion in pancreatic cancer...
  53. ncbi Siegfried Oberndorfer: a tribute to his work and life between Munich, Kiel, Geneva, and Istanbul
    Gunter Kloppel
    Department of Pathology, University of Kiel, Michaelisstr 11, 24105, Kiel, Germany
    Virchows Arch 451:S3-7. 2007
    ..This article pursues the questions why this discovery was so unique and what role it played in the later life of Siegfried Oberndorfer...
  54. ncbi Site-specific biology and pathology of gastroenteropancreatic neuroendocrine tumors
    Gunter Kloppel
    Department of Pathology, University of Kiel, Michaelisstr 11, 24105, Kiel, Germany
    Virchows Arch 451:S9-27. 2007
    ..In addition, a tumor/nodes/metastases classification and a grading system are presented. In the light of these criteria, the various GEP-NET entities are reviewed...
  55. doi Chronic pancreatitis and the differential diagnosis versus pancreatic cancer
    Gunter Kloppel
    Department of Pathology, Universityof Kiel, House 14, Arnold Heller Str 3, 24105 Kiel, Germany
    Arch Pathol Lab Med 133:382-7. 2009
    ..Distinguishing chronic pancreatitis from pancreatic ductal adenocarcinoma (PDAC) is a well-known challenge, at both the clinical and the morphologic level...
  56. doi Interobserver variation in grading and staging of squamous cell carcinoma of the penis in relation to the clinical outcome
    Carsten M Naumann
    Department of Urology and Paediatric Urology, University Hospital Schleswig Holstein, Campus Kiel, Arnold Heller Str 7, D 24105 Kiel, Germany
    BJU Int 103:1660-5. 2009
    ..To examine interobserver variations in assessing grade and stage of penile squamous cell carcinoma (SCC)...
  57. doi Insulinomatosis: a multicentric insulinoma disease that frequently causes early recurrent hyperinsulinemic hypoglycemia
    Martin Anlauf
    Department of Pathology, University of Kiel, Kiel, Germany
    Am J Surg Pathol 33:339-46. 2009
    ..Multicentric insulinoma disease was characterized with regard to its histopathology, multiple endocrine neoplasia type 1 (MEN1) status, precursor lesions, and the risk of hyperinsulinemic hypoglycemia recurrence...
  58. doi Primary lymph node gastrinoma or occult duodenal microgastrinoma with lymph node metastases in a MEN1 patient: the need for a systematic search for the primary tumor
    Martin Anlauf
    Department of Pathology, University of Kiel, Kiel, Germany
    Am J Surg Pathol 32:1101-5. 2008
    ..It is concluded that duodenal gastrinomas that give rise to lymph node metastases may be so tiny that they are easily overlooked in a routine examination and that systematic tissue monitoring is required to identify them...
  59. ncbi Adult diffuse nesidioblastosis: genetically or environmentally induced?
    Gunter Kloppel
    Department of Pathology, University of Kiel, 24105 Kiel, Germany
    Hum Pathol 39:3-8. 2008
    ....
  60. ncbi Endocrine precursor lesions of gastroenteropancreatic neuroendocrine tumors
    Gunter Kloppel
    Department of Pathology, University of Kiel, Michaelisstr 11, 24105, Kiel, Germany
    Endocr Pathol 18:150-5. 2007
    ..The endocrine cell hyperplasia in the colon described in inflammatory bowel disease has neither a genetic nor a definite hormonal background...
  61. ncbi Gastrinoma--morphological aspects
    Gunter Kloppel
    Department of Pathology, University of Kiel, Kiel, Germany
    Wien Klin Wochenschr 119:579-84. 2007
    ..The prognosis of duodenal gastrinomas is better than that of pancreatic gastrinomas, since despite early lymph node metastasis they progress slowly to liver metastasis...
  62. ncbi Oberndorfer and his successors: from carcinoid to neuroendocrine carcinoma
    Gunter Kloppel
    Department of Pathology, University of Kiel, Michaelisstr 11, 24105, Kiel, Germany
    Endocr Pathol 18:141-4. 2007
    ..For the gastroenteropancreatic neuroendocrine tumors, this resulted in a new World Health Organization classification that was recently followed by a tumor-nodes-metastasis classification...
  63. ncbi Endocrine precursor lesions and microadenomas of the duodenum and pancreas with and without MEN1: criteria, molecular concepts and clinical significance
    Martin Anlauf
    Department of Pathology, University of Kiel, Kiel, Germany
    Pathobiology 74:279-84. 2007
    ..Whether these types of microadenomatosis represent novel disease entities and how to diagnose and treat these patients remains to be clarified by further studies...
  64. doi Somatostatin-producing neuroendocrine tumors of the duodenum and pancreas: incidence, types, biological behavior, association with inherited syndromes, and functional activity
    Nele Garbrecht
    Department of Pathology, University of Kiel, Michaelisstr 11, Kiel, Germany
    Endocr Relat Cancer 15:229-41. 2008
    ..MEN1-associated SOM-NETs and GCPGs follow a benign course, while somatostatin-producing pdNECs are aggressive neoplasms. The occurrence of the so-called somatostatinoma syndrome appears to be extremely uncommon...
  65. ncbi Hereditary neuroendocrine tumors of the gastroenteropancreatic system
    Martin Anlauf
    Department of Pathology, University of Kiel, Michaelisstr 11, 24105, Kiel, Germany
    Virchows Arch 451:S29-38. 2007
    ..In addition, GEP-NETs clustering in individual families or associated with other malignancies without known genetic background are discussed...
  66. doi Autoimmune pancreatitis: the clinicopathological characteristics of the subtype with granulocytic epithelial lesions
    Gunter Kloppel
    Department of Pathology, Technical University of Munich, Ismaninger Str 22, 81675 Munich, Germany
    J Gastroenterol 45:787-93. 2010
    ..This article reviews the evidence that GEL-positive AIP or IDCP is a second type of AIP, distinct from LPSP, in regard to pancreatic pathology, immunology and epidemiology...
  67. ncbi Lymphatic spread of ductal pancreatic adenocarcinoma is independent of lymphangiogenesis
    Bence Sipos
    Department of Pathology, University of Kiel, Germany
    J Pathol 207:301-12. 2005
    ..The weak expression of lymphangiogenic cytokines in neoplastic cells and lymphatic vessel proliferation in peritumoural regions and chronic pancreatitis indicate that inflammation may be the reason for the low rate of lymphangiogenesis...
  68. ncbi Expression of stem cell markers and transcription factors during the remodeling of the rat pancreas after duct ligation
    Katharina Peters
    Department of Pathology, University of Kiel, Kiel, Germany
    Virchows Arch 446:56-63. 2005
    ..The findings indicate that the stem cell markers c-Kit and nestin as well as the transcription factors Pdx1 and Nkx2.2 are upregulated in compartments of the pancreas that are involved in islet cell neogenesis after duct ligation...
  69. doi Lymph-node metastases in intermediate-risk squamous cell carcinoma of the penis
    Carsten M Naumann
    Department of Urology and Paediatric Urology, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    BJU Int 102:1102-6. 2008
    ..To evaluate the metastatic risk of pT1 G2 squamous cell carcinoma (SCC) of the penis...
  70. pmc Expression of lymphangiogenic factors and evidence of intratumoral lymphangiogenesis in pancreatic endocrine tumors
    Bence Sipos
    Department of Pathology, University of Kiel, Michaelisstr 11, 24105 Kiel, Germany
    Am J Pathol 165:1187-97. 2004
    ..PET is the first human tumor entity in which VEGF-C-related intratumoral lymphangiogenesis has been demonstrated...
  71. ncbi Serous cystic neoplasms of the pancreas: an immunohistochemical analysis revealing alpha-inhibin, neuron-specific enolase, and MUC6 as new markers
    Markus Kosmahl
    Department of Pathology, University of Kiel, Kiel, Germany
    Am J Surg Pathol 28:339-46. 2004
    ..Because a number of SCNs share MUC1 and MUC6 expression with the pancreatic centroacinar cells, the possibility of a histogenetic relationship has to be considered...
  72. ncbi Where and when does pancreatic carcinoma start?
    Jutta Luttges
    Department of Pathology, University of Kiel, Germany
    Med Klin (Munich) 99:191-5. 2004
    ..Molecular studies revealed that PanIN-2 and PanIN-3 lesions represent a distinct step toward invasive carcinoma...
  73. ncbi A comprehensive characterization of pancreatic ductal carcinoma cell lines: towards the establishment of an in vitro research platform
    Bence Sipos
    Department of Pathology, University of Kiel, Germany
    Virchows Arch 442:444-52. 2003
    ..We conclude that the proposed ultrastructural grading system combined with the proliferative activity provides a basis for further comparative studies of pancreatic ductal adenocarcinoma cell lines...
  74. ncbi Rare ductal adenocarcinoma of the pancreas in patients younger than age 40 years
    Jutta Luttges
    Department of Pathology, University of Kiel, Kiel, Germany
    Cancer 100:173-82. 2004
    ..The objective of the current study was to determine whether the features of PDACs in patients age < 40 years differ from those in older patients. The authors reviewed the literature and their own files...
  75. ncbi Lack of apoptosis in PanIN-1 and PanIN-2 lesions associated with pancreatic ductal adenocarcinoma is not dependent on K-ras status
    Jutta Luttges
    Department of Pathology, University of Kiel, Kiel, Germany
    Pancreas 27:e57-62. 2003
    ..The question is addressed whether mutated K-ras interferes with the regulation of apoptosis or proliferation...
  76. ncbi Vascular endothelial growth factor mediated angiogenic potential of pancreatic ductal carcinomas enhanced by hypoxia: an in vitro and in vivo study
    Bence Sipos
    Department of Pathology, University of Kiel, Kiel, Germany
    Int J Cancer 102:592-600. 2002
    ..Surprisingly, perinecrotic tumor areas, which are supposed to be hypoxic, only rarely showed the expected increase in microvessel density and VEGF expression...
  77. ncbi Persistent hyperinsulinemic hypoglycemia in 15 adults with diffuse nesidioblastosis: diagnostic criteria, incidence, and characterization of beta-cell changes
    Martin Anlauf
    Department of Pathology, University of Kiel, Kiel, Germany
    Am J Surg Pathol 29:524-33. 2005
    ..As approximately 4% of adult patients with PHH are affected by diffuse nesidioblastosis, this disease is not as rare as it has been thought to be. Pathogenetically, the defective insulin secretion could be based on a molecular defect...
  78. ncbi How do gastric carcinoma classification systems relate to mucin expression patterns? An immunohistochemical analysis in a series of advanced gastric carcinomas
    Yesim Gurbuz
    Department of Pathology, University of Kiel, Michaelisstrasse 11, 24105 Kiel, Germany
    Virchows Arch 440:505-11. 2002
    ..It is likely that each of these gastric carcinoma types has its own carcinogenesis...
  79. ncbi Vesicular monoamine transporter 2 (VMAT2) expression in hematopoietic cells and in patients with systemic mastocytosis
    Martin Anlauf
    Department of Pathology, University of Kiel, Michaelisstr 11, 24105 Kiel, Germany
    J Histochem Cytochem 54:201-13. 2006
    ....
  80. ncbi Chronic sclerosing sialadenitis of the submandibular gland is mainly due to a T lymphocyte immune reaction
    Markus Tiemann
    Department of Hematopathology, University of Kiel, Germany
    Mod Pathol 15:845-52. 2002
    ....
  81. ncbi Pancreatic ductal adenocarcinomas with cystic features: neither rare nor uniform
    Markus Kosmahl
    Department of Pathology, University of Kiel, Germany
    Mod Pathol 18:1157-64. 2005
    ..Moreover, not all of the cystic structures we observed were neoplastic in nature. They may also represent non-neoplastic changes, such as retention cysts and inflammatory pseudocysts...
  82. ncbi Pancreatic solid and cystic hamartoma in adults: characterization of a new tumorous lesion
    Ursula Pauser
    Department of Pathology, University of Kiel, Michaelisstrasse 11, 24105 Kiel, Germany
    Am J Surg Pathol 29:797-800. 2005
    ..Because of the irregular arrangement of otherwise mature tissue components of the pancreas, the lesions were considered solid and cystic hamartomas. Their pathogenesis is so far unknown...
  83. ncbi Gastrointestinal mesenchymal tumors - immunophenotypic classification and survival analysis
    Pierre Rudolph
    Department of Pathology, University of Kiel, Michaelisstr 11, 24105 Kiel, Germany
    Virchows Arch 441:238-48. 2002
    ..We conclude that, despite strong morphological similarities, gastrointestinal mesenchymal tumors are heterogeneous in their immunophenotype and biology...
  84. ncbi Precursor lesions in patients with multiple endocrine neoplasia type 1-associated duodenal gastrinomas
    Martin Anlauf
    Department of Pathology, Univeristy of Kiel, Germany
    Gastroenterology 128:1187-98. 2005
    ..Precursor lesions may precede the development of duodenal gastrinomas because, in contrast to sporadic gastrinomas, these tumors are usually multiple...
  85. ncbi Cellular hamartoma resembling gastrointestinal stromal tumor: a solid tumor of the pancreas expressing c-kit (CD117)
    Ursula Pauser
    Department of Pathology, University of Kiel, Germany
    Mod Pathol 18:1211-6. 2005
    ..The follow-up (2 and 4 years) of the patients was uneventful. We propose to designate the tumors as 'cellular hamartoma resembling gastrointestinal stromal tumor...
  86. ncbi Pancreatic mucinous noncystic (colloid) carcinomas and intraductal papillary mucinous carcinomas are usually microsatellite stable
    Jutta Luttges
    Department of Pathology, University of Kiel, Germany
    Mod Pathol 16:537-42. 2003
    ..The data suggest that pancreatic carcinomas with a mucinous phenotype (MUC2+/MUC1-) do not appear to normally exhibit mutations in the mismatch repair genes and therefore differ in their carcinogenesis from those in other organs...
  87. doi [IgG4-related systemic disease with autoimmune pancreatitis and lung involvement primarily presenting as pancreatic cancer with pulmonary metastases]
    D Schmitz
    Institut für Allgemeine Pathologie, Technische Universitat Munchen, Munchen, Germany
    Z Gastroenterol 51:290-5. 2013
    ..Type 1 autoimmune pancreatitis (AIP) is usually part of an IgG4-related systemic disease. AIP Typ 2 is an IgG4-independent pancreatic disease. For both entities pancreas cancer is the most important differential diagnosis...
  88. ncbi WHO-classification 2000: exocrine pancreatic tumors
    G Kloppel
    Department of Pathology, University of Kiel
    Verh Dtsch Ges Pathol 85:219-28. 2001
    ....
  89. ncbi The mucin profile of noninvasive and invasive mucinous cystic neoplasms of the pancreas
    J Luttges
    Department of Pathology, University of Kiel, Kiel, Germany
    Am J Surg Pathol 26:466-71. 2002
    ....
  90. pmc Allelic deletion of the MEN1 gene in duodenal gastrin and somatostatin cell neoplasms and their precursor lesions
    M Anlauf
    Department of Pathology W, University of Kiel, Michaelisstr 11, 24105 Kiel, Germany
    Gut 56:637-44. 2007
    ..Patients with a multiple endocrine neoplasia type 1 (MEN1)-associated Zollinger-Ellison syndrome (ZES) show multifocal duodenal gastrinomas and precursor lesions...
  91. ncbi Tumor stroma interactions induce chemoresistance in pancreatic ductal carcinoma cells involving increased secretion and paracrine effects of nitric oxide and interleukin-1beta
    Susanne Müerköster
    Laboratory of Molecular Gastroenterology and Hepatology, 1st Department of Medicine, UKSH Campus Kiel, Schittenhelmstrasse 12, 24105 Kiel, Germany
    Cancer Res 64:1331-7. 2004
    ..These findings substantiate the implication of tumor-stromal interactions in the chemoresistance of pancreatic carcinoma...
  92. doi Glucagon cell adenomatosis: a newly recognized disease of the endocrine pancreas
    Tobias Henopp
    Department of Pathology, University of Tubingen, Liebermeisterstr 8, 72076 Tubingen, Germany
    J Clin Endocrinol Metab 94:213-7. 2009
    ..We observed a previously undescribed multicentric glucagon-producing tumor disease that is not related to MEN1...
  93. pmc The biological relevance of gastric neuroendocrine tumors
    G Kloppel
    Department of Pathology, University of Kiel, Germany
    Yale J Biol Med 69:69-74. 1996
    ..It occurs as multiple lesions in the gastric body fundus and has a lower metastatic rate than type 2 gastric neuroendocrine tumor. Type 4 gastric neuroendocrine tumor corresponds to a small-cell carcinoma...
  94. doi Fatal pneumocystis jirovecii pneumonia in a case of ectopic Cushing's syndrome due to neuroendocrine carcinoma of the kidney
    A Arlt
    1st Department of Medicine, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    Exp Clin Endocrinol Diabetes 116:515-9. 2008
    ....
  95. ncbi Idiosyncratic drug allergic phenprocoumon-induced hepatitis with subacute liver failure initially misdiagnosed as autoimmune hepatitis
    H Hinrichsen
    First Dept of Medicine, Christian Albrechts University, Kiel, Germany
    Scand J Gastroenterol 36:780-3. 2001
    ..Coumarin anticoagulants are known to cause hepatotoxicity, but only a few cases have been reported. Coumarins are usually administered following cardiovascular surgery and the differential diagnosis is post-transfusion hepatitis...
  96. ncbi Increased expression of the E3-ubiquitin ligase receptor subunit betaTRCP1 relates to constitutive nuclear factor-kappaB activation and chemoresistance in pancreatic carcinoma cells
    Susanne Müerköster
    Laboratory of Molecular Gastroenterology and Hepatology, First Department of Medicine, Kiel University, UKSH Campus Kiel, Kiel, Germany
    Cancer Res 65:1316-24. 2005
    ..Altogether, our findings of the elevated betaTRCP1 expression in pancreatic carcinoma cells pinpoint to another important mediator of constitutive NF-kappaB activation and thereby of chemoresistance...
  97. ncbi [Decreased number of R1-resections in radical retropubic prostatectomy. Use of a newly developed fast sectioning technique]
    P M Braun
    Klinik für Urologie und Kinderurologie, Universitatsklinikum Schleswig Holstein, Campus Kiel
    Urologe A 44:1324-31. 2005
    ..2%, P < or =0.001). Our results demonstrate that the new frozen margin technique is clearly more sensitive for intraoperative detection of positive margins and thus leads to substantially higher rates of negative surgical margins...
  98. ncbi Neuroendocrine carcinomas of the prostate and urinary bladder: a diagnostic and therapeutic challenge
    Burkhard Helpap
    Department of Pathology, Academic Hospital of the University of Freiburg, Postfach 720, 78207 Singen, Germany
    Virchows Arch 440:241-8. 2002
    ..In the case of high-grade neuroendocrine carcinomas, early diagnosis and initiation of appropriate chemotherapy may increase survival and potentially induce complete remission in individual cases...
  99. ncbi Autoimmune pancreatitis: frequency, IgG4 expression, and clonality of T and B cells
    Motohiro Kojima
    Department of Pathology, University of Kiel, Germany
    Am J Surg Pathol 31:521-8. 2007
    ..High density infiltrates of IgG4 positive plasma cells are diagnostic for AIP, but are seen in less than half of the cases. T or B-cell oligoclonality could not be established as a feature of AIP...