T Klockgether

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. ncbi Spinocerebellar ataxia types 1, 2, 3, and 6: disease severity and nonataxia symptoms
    T Schmitz-Hübsch
    Department of Neurology, University Hospital of Bonn, Bonn, Germany
    Neurology 71:982-9. 2008
  2. ncbi Sporadic ataxia with adult onset: classification and diagnostic criteria
    Thomas Klockgether
    Department of Neurology, University Hospital Bonn, and Deutsches Zentrum für Neurodegenerative Erkrankungen DZNE, Bonn, Germany
    Lancet Neurol 9:94-104. 2010
  3. ncbi Recent advances in degenerative ataxias
    T Klockgether
    Department of Neurology, University of Bonn, Germany
    Curr Opin Neurol 13:451-5. 2000
  4. ncbi The clinical diagnosis of autosomal dominant spinocerebellar ataxias
    Thomas Klockgether
    Department of Neurology, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Cerebellum 7:101-5. 2008
  5. ncbi Update on degenerative ataxias
    Thomas Klockgether
    Department of Neurology, University Hospital Bonn and German Center for Neurodegenerative Disorders, Bonn, Germany
    Curr Opin Neurol 24:339-45. 2011
  6. ncbi Parkinsonism & related disorders. Ataxias
    Thomas Klockgether
    Department of Neurology, University Hospital of Bonn, Bonn, Germany
    Parkinsonism Relat Disord 13:S391-4. 2007
  7. ncbi Sporadic adult-onset ataxia of unknown etiology
    Thomas Klockgether
    Department of Neurology, University Hospital Bonn, Germany
    Handb Clin Neurol 103:253-62. 2012
  8. ncbi Milestones in ataxia
    Thomas Klockgether
    Department of Neurology, University Hospital Bonn, Bonn, Germany
    Mov Disord 26:1134-41. 2011
  9. ncbi Parkinson's disease: clinical aspects
    Thomas Klockgether
    Department of Neurology, University Hospital of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Cell Tissue Res 318:115-20. 2004
  10. ncbi [Ataxias. Diagnostic procedure and treatment]
    T Klockgether
    Klinik fur Neurologie, Universitatsklinikum Bonn
    Nervenarzt 76:1275-83; quiz 1284-5. 2005

Collaborators

Detail Information

Publications150 found, 100 shown here

  1. ncbi Spinocerebellar ataxia types 1, 2, 3, and 6: disease severity and nonataxia symptoms
    T Schmitz-Hübsch
    Department of Neurology, University Hospital of Bonn, Bonn, Germany
    Neurology 71:982-9. 2008
    ..To identify factors that determine disease severity and clinical phenotype of the most common spinocerebellar ataxias (SCAs), we studied 526 patients with SCA1, SCA2, SCA3. or SCA6...
  2. ncbi Sporadic ataxia with adult onset: classification and diagnostic criteria
    Thomas Klockgether
    Department of Neurology, University Hospital Bonn, and Deutsches Zentrum für Neurodegenerative Erkrankungen DZNE, Bonn, Germany
    Lancet Neurol 9:94-104. 2010
    ..In addition, specific serological and genetic markers are available that allow a definite diagnosis in many cases...
  3. ncbi Recent advances in degenerative ataxias
    T Klockgether
    Department of Neurology, University of Bonn, Germany
    Curr Opin Neurol 13:451-5. 2000
    ..The aetiology of many sporadic ataxias remains obscure. In some patients, association of ataxia with specific serum antibodies (antigliadin, antiglutamic acid decarboxylase) suggests an immune pathogenesis...
  4. ncbi The clinical diagnosis of autosomal dominant spinocerebellar ataxias
    Thomas Klockgether
    Department of Neurology, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Cerebellum 7:101-5. 2008
    ..Depending on the geographical origin of the family, these tests will lead to positive diagnostic results in at least half of the families...
  5. ncbi Update on degenerative ataxias
    Thomas Klockgether
    Department of Neurology, University Hospital Bonn and German Center for Neurodegenerative Disorders, Bonn, Germany
    Curr Opin Neurol 24:339-45. 2011
    ..On the basis of a review of the literature published in 2009 and 2010, this review gives an update of the most recent developments in the field of ataxia...
  6. ncbi Parkinsonism & related disorders. Ataxias
    Thomas Klockgether
    Department of Neurology, University Hospital of Bonn, Bonn, Germany
    Parkinsonism Relat Disord 13:S391-4. 2007
    ..The causative mutations of many hereditary ataxias have recently been identified. Therapies based on the knowledge of the underlying molecular pathogenesis are available for a number of ataxia disorders...
  7. ncbi Sporadic adult-onset ataxia of unknown etiology
    Thomas Klockgether
    Department of Neurology, University Hospital Bonn, Germany
    Handb Clin Neurol 103:253-62. 2012
    ..Neuropathological and imaging studies show an isolated cerebellar cortical degeneration with no or only mild brainstem involvement. There is no established therapy for SAOA...
  8. ncbi Milestones in ataxia
    Thomas Klockgether
    Department of Neurology, University Hospital Bonn, Bonn, Germany
    Mov Disord 26:1134-41. 2011
    ..Effective therapies for ataxias are still lacking. However, novel drug targets are under investigation, and it is expected that there will be an increasing number of therapeutic trials in ataxia...
  9. ncbi Parkinson's disease: clinical aspects
    Thomas Klockgether
    Department of Neurology, University Hospital of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Cell Tissue Res 318:115-20. 2004
    ..In particular, the analysis of the properties that the neuronal cell types involved in PD have in common and that might make them susceptible to degeneration is essential...
  10. ncbi [Ataxias. Diagnostic procedure and treatment]
    T Klockgether
    Klinik fur Neurologie, Universitatsklinikum Bonn
    Nervenarzt 76:1275-83; quiz 1284-5. 2005
    ..Therapies based on the underlying molecular pathogenesis are available for a number of ataxia disorders...
  11. ncbi Molecular analysis of the PTEN, TP53 and CDKN2A tumor suppressor genes in long-term survivors of glioblastoma multiforme
    J A Kraus
    Department of Neurology, University of Bonn Medical Center, Germany
    J Neurooncol 48:89-94. 2000
    ....
  12. ncbi Peroxisome proliferator-activated receptor gamma agonists protect cerebellar granule cells from cytokine-induced apoptotic cell death by inhibition of inducible nitric oxide synthase
    M T Heneka
    Department of Neurology, University of Bonn, Germany
    J Neuroimmunol 100:156-68. 1999
    ....
  13. ncbi Common genetic variants of homocysteine metabolism in ischemic stroke: a case-control study
    M Linnebank
    Department of Neurology, University Hospital Bonn, Bonn, Germany
    Eur J Neurol 12:614-8. 2005
    ..677 C > T could be a minor factor of vulnerability especially in young patients (TT genotype), which might be helpful for the clinical work-up of stroke cases and for preventive dietary strategies...
  14. ncbi Proton magnetic resonance spectroscopy of the motor cortex in 70 patients with amyotrophic lateral sclerosis
    C Pohl
    Department of Neurology, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Arch Neurol 58:729-35. 2001
    ..To evaluate proton magnetic resonance spectroscopy for detection and monitoring of upper motoneuron degeneration in patients with amyotrophic lateral sclerosis...
  15. ncbi High level expression of expanded full-length ataxin-3 in vitro causes cell death and formation of intranuclear inclusions in neuronal cells
    B O Evert
    Department of Neurology, University of Tubingen, 72076 Tubingen, Germany
    Hum Mol Genet 8:1169-76. 1999
    ..These data show that high level expression of expanded full-length ataxin-3 in a neuron-like cell line generates ultrastructural alterations of SCA3 pathogenesis and results in increased spontaneous non-apoptotic cell death...
  16. ncbi Inflammatory genes are upregulated in expanded ataxin-3-expressing cell lines and spinocerebellar ataxia type 3 brains
    B O Evert
    Department of Neurology, University of Bonn, 53105 Bonn, Germany
    J Neurosci 21:5389-96. 2001
    ..Finally, increased numbers of reactive astrocytes and activated microglial cells were found in SCA3 pons. These results suggest that inflammatory processes are involved in the pathogenesis of SCA3...
  17. ncbi Cognitive deficits in spinocerebellar ataxia 2
    K Burk
    Department of Neurology, University of Tubingen, Germany
    Brain 122:769-77. 1999
    ..Intellectual impairment should therefore not be interpreted as a secondary effect of progressive motor disability, but represents an important and independent part of the SCA2 phenotype...
  18. ncbi Glutathione depletion and neuronal cell death: the role of reactive oxygen intermediates and mitochondrial function
    U Wullner
    Department of Neurology, Eberhard Karls University, Hoppe Seyler Str 3, D 72076, Tubingen, Germany
    Brain Res 826:53-62. 1999
    ..No typical features of apoptosis, i.e., no chromatin condensation or DNA fragmentation were detected after GSH depletion after BSO or EA treatment...
  19. ncbi Neuropsychological outcome after chemotherapy for primary CNS lymphoma: a prospective study
    K Fliessbach
    Department of Neurology, University Hospital Bonn, Germany
    Neurology 64:1184-8. 2005
    ..The impact of high-dose methotrexate (MTX)-based chemotherapy alone on cognition and quality of life (QOL) is controversial...
  20. ncbi Voxel-based morphometry and voxel-based relaxometry in multiple system atrophy-a comparison between clinical subtypes and correlations with clinical parameters
    M Minnerop
    Department of Neurology, University Hospital of Bonn, Bonn, Germany
    Neuroimage 36:1086-95. 2007
    ..In MSA-C, there was a stronger reduction of gray matter in the basal parts of the cerebellum, of white matter in the brainstem and of the relaxation rate R2 in the cerebellum and brainstem...
  21. ncbi MTX-induced white matter changes are associated with polymorphisms of methionine metabolism
    M Linnebank
    Department of Neurology, University Hospital Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Neurology 64:912-3. 2005
    ..7 (p = 0.001). The authors conclude that methionine metabolism influences MTX neurotoxicity...
  22. ncbi Cell death and apoptosis regulating proteins in Parkinson's disease--a cautionary note
    U Wullner
    Department of Neurology, Friedrich Wilhelms University, Bonn, Germany
    Acta Neuropathol 97:408-12. 1999
    ..No significant changes of any of the apoptosis regulating proteins were apparent in PD substantia nigra. These findings do not support the hypothesis that apoptosis plays a central role in the pathogenesis of PD...
  23. ncbi Autonomic dysfunction in 3414 Parkinson's disease patients enrolled in the German Network on Parkinson's disease (KNP e.V.): the effect of ageing
    U Wullner
    Department of Neurology, University of Rheinische Friedrich Wilhelms, Bonn, Germany
    Eur J Neurol 14:1405-8. 2007
    ..Sleep disturbances were more common in women and a correlation was found with disease duration only supporting the notion that sleep is specifically affected in PD...
  24. ncbi Sporadic cerebellar ataxia associated with gluten sensitivity
    K Burk
    Department of Neurology, University of Tubingen, Germany
    Brain 124:1013-9. 2001
    ....
  25. ncbi Effect of 1-methyl-4-phenylpyridinium on glutathione in rat pheochromocytoma PC 12 cells
    J Seyfried
    Department of Neurology, University of Tubingen, Germany
    Neurochem Int 36:489-97. 2000
    ..Our data suggest that MPP+ has differential effects on glutathione homeostasis depending on the degree of complex I-inhibition and that inhibition of complex I is not sufficient to generate ROI in this paradigm...
  26. ncbi Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice
    Michael T Heneka
    Department of Neurology, University of Bonn, Bonn, Germany
    Brain 128:1442-53. 2005
    ..These findings demonstrate that anti-inflammatory drugs can act rapidly to inhibit inflammatory responses in the brain and negatively modulate amyloidogenesis...
  27. ncbi Neuronal intranuclear inclusions, dysregulation of cytokine expression and cell death in spinocerebellar ataxia type 3
    B O Evert
    Department of Neurology, University of Bonn, Germany
    Clin Neuropathol 25:272-81. 2006
    ..CONCLUSIONS: Our data suggest that the selectively affected neuronal populations in SCA3 undergo a complex alteration of gene expression independent from the formation of NI...
  28. ncbi Bcl-2, Bax and Bcl-x expression in neuronal apoptosis: a study of mutant weaver and lurcher mice
    U Wullner
    Department of Neurology, Eberhard Karls University, Tubingen, Germany
    Acta Neuropathol 96:233-8. 1998
    ....
  29. ncbi Acute methotrexate-induced encephalopathy--causal relation to homozygous allelic state for MTR c.2756A>G (D919G)?
    M Linnebank
    Dept of Neurology, University Hospital of Bonn, Germany
    J Chemother 19:455-7. 2007
    ..This finding encourages further studies to determine to what extent the individual conditions of folate and methionine metabolism influence the effects or side-effects of MTX treatment...
  30. ncbi Executive dysfunction in spinocerebellar ataxia type 1
    K Burk
    Department of Neurology, University of Tubingen, Hoppe Seyler Strasse 3, D 72076 Tubingen, Germany
    Eur Neurol 46:43-8. 2001
    ....
  31. ncbi Endonucleolytic DNA fragmentation is not required for apoptosis of cultured rat cerebellar granule neurons
    J B Schulz
    Department of Neurology, University of Tubingen, Germany
    Neurosci Lett 245:9-12. 1998
    ....
  32. ncbi Association study of dopamine D2, D3, D4 receptor and serotonin transporter gene polymorphisms with sleep attacks in Parkinson's disease
    Sebastian Paus
    Department of Neurology, University of Bonn, Bonn, Germany
    Mov Disord 19:705-7. 2004
  33. ncbi Differential effects of L-buthionine sulfoximine and ethacrynic acid on glutathione levels and mitochondrial function in PC12 cells
    J Seyfried
    Department of Neurology, University of Tubingen, Germany
    Neurosci Lett 264:1-4. 1999
    ..These findings suggest that mitochondrial GSH is critical for the maintenance of mitochondrial function and cellular viability...
  34. ncbi The variant methylenetetrahydrofolate reductase c.1298A>C (p.E429A) is associated with multiple sclerosis in a German case-control study
    L Klotz
    Department of Neurology, University Bonn, Bonn, Germany
    Neurosci Lett 468:183-5. 2010
    ..If confirmed in an independent study sample, the underlying mechanisms should be investigated, which may lead to novel insights in biochemical factors influencing the aetiology and pathophysiology of MS...
  35. ncbi SCA Functional Index: a useful compound performance measure for spinocerebellar ataxia
    T Schmitz-Hübsch
    Department of Neurology, University Hospital of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Neurology 71:486-92. 2008
    ..To evaluate the usefulness of functional measures in patients with spinocerebellar ataxia (SCA)...
  36. ncbi Sporadic adult onset ataxia of unknown etiology : a clinical, electrophysiological and imaging study
    M Abele
    Dept of Neurology, University of Bonn, Sigmund Freud Str 25, 53105, Bonn, Germany
    J Neurol 254:1384-9. 2007
    ..The sporadic adult onset ataxias of unknown etiology (SAOA) denote the non-hereditary degenerative adult onset ataxias that are distinct from multiple system atrophy (MSA)...
  37. ncbi Heparin-induced thrombocytopenia in neurologic patients treated with low-molecular-weight heparin
    C Pohl
    Department of Neurology, University Hospital Bonn, Germany
    Neurology 64:1285-7. 2005
    ..5% of 200 patients treated with UFH (p = 0.17). The rate of heparin-induced antibodies in patients treated with LMWH was lower than in patients treated with UFH (1.8 vs 20.5%; p < 0.001)...
  38. ncbi Restless legs syndrome in spinocerebellar ataxia types 1, 2, and 3
    M Abele
    Department of Neurology, University of Tubingen, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
    J Neurol 248:311-4. 2001
    ..The probability of developing RLS is related principally to the period over which the CAG repeat mutation exerts its effect and not to CAG repeat length or age of ataxia onset...
  39. ncbi Combined systemic and intraventricular chemotherapy in primary CNS lymphoma: a pilot study
    U Schlegel
    Department of Neurology, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    J Neurol Neurosurg Psychiatry 71:118-22. 2001
    ..In conclusion, primary chemotherapy based on high dose MTX and ara-C is highly efficient in PCNSL. Toxicity is manageable in patients younger than 70 years...
  40. ncbi Temporal, regional, and cell-specific changes of iNOS expression after intrastriatal microinjection of interferon gamma and bacterial lipopolysaccharide
    M T Heneka
    Department of Neurology, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    J Chem Neuroanat 18:167-79. 2000
    ....
  41. ncbi Responsiveness of different rating instruments in spinocerebellar ataxia patients
    T Schmitz-Hübsch
    Department of Neurology, University Hospital of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Neurology 74:678-84. 2010
    ..To determine the longitudinal metric properties of recently developed clinical assessment tools in spinocerebellar ataxia (SCA)...
  42. ncbi Proton magnetic resonance spectroscopy and transcranial magnetic stimulation for the detection of upper motor neuron degeneration in ALS patients
    C Pohl
    Department of Neurology, University of Bonn, Sigmund Freud Str 25, D 53105, Bonn, Germany
    J Neurol Sci 190:21-7. 2001
    ..We conclude that the combined use of 1H-MRS and TMS increases diagnostic accuracy for the detection of upper motor neuron involvement in ALS patients...
  43. ncbi Cell death in polyglutamine diseases
    B O Evert
    Department of Neurology, University of Bonn, Germany
    Cell Tissue Res 301:189-204. 2000
    ....
  44. ncbi Peroxisome proliferator-activated receptor-gamma ligands reduce neuronal inducible nitric oxide synthase expression and cell death in vivo
    M T Heneka
    Department of Neurology, University of Bonn, 53105 Bonn, Germany
    J Neurosci 20:6862-7. 2000
    ....
  45. ncbi Phenotype assignment in symptomatic female carriers of X-linked adrenoleukodystrophy
    S Schmidt
    Department of Neurology, University of Bonn, Germany
    J Neurol 248:36-44. 2001
    ..No evidence of adrenal insufficiency was detected in any of the patients...
  46. ncbi Serum autoantibody responses to myelin oligodendrocyte glycoprotein and myelin basic protein in X-linked adrenoleukodystrophy and multiple sclerosis
    S Schmidt
    Department of Neurology, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    J Neuroimmunol 119:88-94. 2001
    ..These findings may have important implications for the understanding of humoral anti-myelin immunoreactivity in demyelinating diseases of the central nervous system such as X-ALD and MS...
  47. ncbi Effects of 7-nitroindazole, NG-nitro-L-arginine, and D-CPPene on harmaline-induced postural tremor, N-methyl-D-aspartate-induced seizures, and lisuride-induced rotations in rats with nigral 6-hydroxydopamine lesions
    F Eblen
    Department of Neurology, University of Tubingen, Germany
    Eur J Pharmacol 299:9-16. 1996
    ..The novel observation that D-CPPene suppresses harmaline-induced tremor leads us to suggest that NMDA receptor antagonists should be considered as novel therapeutics for postural tremor...
  48. ncbi Expression of neurotrophins and neurotrophin receptors in the cerebellum of mutant weaver and lurcher mice
    U Wullner
    Department of Neurology, Eberhard Karls University, Hoppe Seyler Str 3, D 72076 Tubingen, Germany
    Brain Res Dev Brain Res 110:1-6. 1998
    ..Our results suggest that the loss of specific neuron populations in the cerebellum of either mutant occurs via mechanisms either independent or downstream of the neurotrophins examined in this study...
  49. ncbi The nuclear receptor PPAR gamma selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity
    Luisa Klotz
    Institutes of Molecular Medicine and Experimental Immunology, Department of Neurology, University of Bonn, Bonn 53105, Germany
    J Exp Med 206:2079-89. 2009
    ..We therefore propose that PPAR gamma represents a promising molecular target for specific immunointervention in Th17-mediated autoimmune diseases such as MS...
  50. ncbi An interleukin-6 promoter variant is not associated with an increased risk for Alzheimer's disease
    Candan Depboylu
    Department of Neurology, Rheinische Friedrich Wilhelms University Bonn, Bonn, Germany
    Dement Geriatr Cogn Disord 17:170-3. 2004
    ..No evidence of an earlier age at onset for carriers of the C allele was evaluated. We conclude that IL-6 (-174) polymorphism does not influence the risk of developing AD in our cohort...
  51. ncbi Induction of apoptosis in human and rat glioma by agonists of the nuclear receptor PPARgamma
    Thomas Zander
    Department of Neurology, University Bonn, Germany
    J Neurochem 81:1052-60. 2002
    ..Taken together, treatment of glioma cells with PPARgamma agonists may hold therapeutic potential for the treatment of gliomas...
  52. ncbi Locus ceruleus degeneration promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice
    Michael T Heneka
    Department of Neurology, University of Bonn, 53127 Bonn, Germany
    J Neurosci 26:1343-54. 2006
    ..Our data demonstrate that the degeneration of LC affects morphology, metabolism, and function of amyloid plaque-containing higher brain regions in APP23 mice. We postulate that LC degeneration substantially contributes to AD development...
  53. ncbi Cognitive deficits in spinocerebellar ataxia type 1, 2, and 3
    K Burk
    Department of Neurology, University of Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
    J Neurol 250:207-11. 2003
    ....
  54. ncbi Sensorineural hearing loss in patients with chronic progressive external ophthalmoplegia or Kearns-Sayre syndrome
    C Kornblum
    Dept of Neurology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    J Neurol 252:1101-7. 2005
    ..Audiological findings suggested a cochlear origin of hearing loss in all subjects. Our results demonstrate that CPEO or KSS patients due to mtDNA deletion or A3243G PM are at high risk of developing sensorineural hearing deficits...
  55. ncbi Cricopharyngeal achalasia is a common cause of dysphagia in patients with mtDNA deletions
    C Kornblum
    Department of Neurology, University of Bonn, Germany
    Neurology 56:1409-12. 2001
    ..Cricopharyngeal myotomy may be an effective treatment in selected cases with severe cricopharyngeal obstruction...
  56. ncbi Does high-field MR imaging have an influence on the classification of patients with clinically isolated syndromes according to current diagnostic mr imaging criteria for multiple sclerosis?
    M P Wattjes
    Department of Radiology Neuroradiology, University Hospital of Bonn, Bonn, Germany
    AJNR Am J Neuroradiol 27:1794-8. 2006
    ....
  57. ncbi Cerebellar ataxia with glutamic acid decarboxylase autoantibodies
    M Abele
    Department of Neurology, University of Tubingen, Germany
    Neurology 52:857-9. 1999
    ..The authors report a patient with progressive cerebellar ataxia, insulin-dependent diabetes mellitus, and GAD antibodies who responded to i.v. immunoglobulins...
  58. ncbi Neurologic complications in immune-mediated heparin-induced thrombocytopenia
    C Pohl
    Department of Neurology, Rheinische Friedrich Wilhelms Universitat, Bonn, Germany
    Neurology 54:1240-5. 2000
    ..To evaluate neurologic complications in patients with immune-mediated heparin-induced thrombocytopenia (HIT) with respect to incidence, clinical characteristics, outcome, and therapy...
  59. ncbi The natural history of spinocerebellar ataxia type 1, 2, 3, and 6: a 2-year follow-up study
    H Jacobi
    Department of Neurology, University Hospital of Bonn, Bonn, Germany
    Neurology 77:1035-41. 2011
    ..We report the results of the 1- and 2-year follow-up visits...
  60. ncbi Probable multiple system atrophy in a German family
    U Wullner
    Department of Neurology, UKB, Sigmund Freud Strasse, Bonn, Germany
    J Neurol Neurosurg Psychiatry 75:924-5. 2004
    ..The patients presented initially with either parkinsonian or cerebellar signs, and developed severe autonomic failure and typical atrophy of the brain stem and cerebellum in the course of the disease...
  61. ncbi Methionine metabolism and phenotypic variability in X-linked adrenoleukodystrophy
    M Linnebank
    Department of Neurology, University Hospital Bonn, Bonn, Germany
    Neurology 66:442-3. 2006
    ..002), suggesting that methionine metabolism might contribute to the phenotypic variability in adrenoleukodystrophy...
  62. ncbi Nerve conduction studies in multiple system atrophy
    M Abele
    Department of Neurology, University of Tubingen, Germany
    Eur Neurol 43:221-3. 2000
    ..The data provide evidence that the peripheral nervous system is differentially affected in MSA-C and MSA-P...
  63. ncbi Tremor in Parkinson's disease is not associated with the DRD3 Ser9Gly polymorphism
    S Paus
    Department of Neurology, University of Bonn, Sigmund Freud Strasse 25, 53127 Bonn, Germany
    Parkinsonism Relat Disord 16:381-3. 2010
    ..Additional studies incorporating symptoms at disease onset, and grading of tremor response to dopaminergic therapy, are warranted...
  64. ncbi Noradrenaline induces expression of peroxisome proliferator activated receptor gamma (PPARgamma) in murine primary astrocytes and neurons
    Luisa Klotz
    Department of Neurology, University of Bonn, Bonn, Germany
    J Neurochem 86:907-16. 2003
    ..Conversely, decreased NA due to LC cell death in AD may reduce endogenous PPARgamma expression and therefore potentiate neuroinflammatory processes...
  65. ncbi Minocycline 1-year therapy in multiple-system-atrophy: effect on clinical symptoms and [(11)C] (R)-PK11195 PET (MEMSA-trial)
    Richard Dodel
    Department of Neurology, Philipps University of Marburg, 35039 Marburg, Germany
    Mov Disord 25:97-107. 2010
    ..This prospective, 48 week, randomized, double-blind, multinational study failed to show a clinical effect of minocycline on symptom severity as assessed by clinical motor function...
  66. ncbi Autosomal dominant cerebellar ataxia type I: oculomotor abnormalities in families with SCA1, SCA2, and SCA3
    K Burk
    Department of Neurology, University of Tubingen, Hoppe Seyler Strasse 3, D 72076 Tubingen, Germany
    J Neurol 246:789-97. 1999
    ..The eye movement disorder of SCA1 patients, however, overlaps with both SCA2 and SCA3...
  67. ncbi Molecular genetic alterations in glioblastomas with oligodendroglial component
    J A Kraus
    Department of Neurology, University of Bonn Medical Center, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Acta Neuropathol 101:311-20. 2001
    ..Furthermore, a subset of these tumors demonstrates LOH on 1p, i.e., an alteration that has recently been linked to chemosensitivity and good prognosis in anaplastic oligodendrogliomas...
  68. ncbi Prevalence of antigliadin antibodies in ataxia patients
    M Abele
    Department of Neurology, University of Bonn, Germany
    Neurology 60:1674-5. 2003
    ..Although we found a trend toward a higher prevalence of antigliadin antibodies in patients with sporadic ataxia and dominant ataxia, our data do not support an association of ataxia with antigliadin antibodies...
  69. ncbi Identification of inhibitor-of-differentiation 2 (Id2) as a modulator of neuronal apoptosis
    M Gleichmann
    Department of Neurology, , , Germany
    J Neurochem 80:755-62. 2002
    ..Further, gene transfer- mediated overexpression of Id2 induces neuronal cell death both in high potassium and low potassium conditions. Thus, the present study defines a role for Id2 in the modulation of neuronal apoptosis...
  70. ncbi Genes involved in hereditary ataxias
    T Klockgether
    Dept of Neurology, University of Bonn, Germany
    Trends Neurosci 21:413-8. 1998
    ..In another group of dominant disorders, episodic ataxia type I and type 2 (EA-I, EA-2) and SCA6, the mutations affect genes that code for ion channels...
  71. ncbi Qigong exercise for the symptoms of Parkinson's disease: a randomized, controlled pilot study
    Tanya Schmitz-Hübsch
    Department of Neurology, University of Bonn, Germany
    Mov Disord 21:543-8. 2006
    ..Depression scores decreased in both groups, whereas the incidence of several nonmotor symptoms decreased in the treatment group only...
  72. ncbi Sepsis causes neuroinflammation and concomitant decrease of cerebral metabolism
    Alexander Semmler
    Department of Neurology, University Bonn, Bonn, Germany
    J Neuroinflammation 5:38. 2008
    ..Changes in cerebral blood flow, release of inflammatory molecules and metabolic alterations contribute to neuronal dysfunction and cell death...
  73. ncbi Noradrenergic depletion potentiates beta -amyloid-induced cortical inflammation: implications for Alzheimer's disease
    Michael T Heneka
    Department of Neurology, University of Bonn, Germany 53127
    J Neurosci 22:2434-42. 2002
    ..These data demonstrate that LC loss and NE depletion augment inflammatory responses to Abeta and suggest that LC loss in AD is permissive for increased inflammation and neuronal cell death...
  74. ncbi Proinflammatory stimulation and pioglitazone treatment regulate peroxisome proliferator-activated receptor gamma levels in peripheral blood mononuclear cells from healthy controls and multiple sclerosis patients
    Luisa Klotz
    Department of Neurology, University of Bonn, Germany
    J Immunol 175:4948-55. 2005
    ....
  75. ncbi Gene dosage-dependent effects of bcl-2 expression on cellular survival and redox status
    Jan Seyfried
    Department of Neurology, University of Bonn, Bonn, Germany
    Free Radic Biol Med 34:1517-30. 2003
    ..Our data suggest that bcl-2 expression is beneficial only in a limited gene dosage range and that high-level expression of bcl-2 exerts potential deleterious effects...
  76. ncbi Lack of association of interleukin-10 promoter region polymorphisms with Alzheimer's disease
    Candan Depboylu
    Department of Neurology, Friedrich Wilhelms University, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Neurosci Lett 342:132-4. 2003
    ..We conclude that polymorphisms in the IL-10 promoter region do not increase the risk of developing AD...
  77. ncbi Antiparkinsonian activity of Ro 25-6981, a NR2B subunit specific NMDA receptor antagonist, in animal models of Parkinson's disease
    Peter Andreas Löschmann
    Department of Neurology, University of Tubingen, Tuebingen, Germany
    Exp Neurol 187:86-93. 2004
    ..The present observations suggest a therapeutic potential of NR2B-selective NMDA receptor antagonists in the management of PD...
  78. ncbi Patients with Multiple Sclerosis and concomitant uveitis/periphlebitis retinae are not distinct from those without intraocular inflammation
    S Schmidt
    Department of Neurology, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    J Neurol Sci 187:49-53. 2001
    ..No correlation between the type of MS and uveitis, or between the degree of neurological disability and the type of uveitis was found...
  79. ncbi The methionine synthase polymorphism D919G alters susceptibility to primary central nervous system lymphoma
    M Linnebank
    Department of Neurology, University Hospital of Bonn, Sigmund Freud Str 25, Bonn D 53125, Germany
    Br J Cancer 90:1969-71. 2004
    ..26, CI(95%): 0.09-0.74; P=0.005), suggesting a protective function of the G allele. These data stimulate further epidemiological and functional studies focusing on the role of homocysteine and folate metabolism in lymphoma tumorigenesis...
  80. ncbi Flupirtine and retigabine prevent L-glutamate toxicity in rat pheochromocytoma PC 12 cells
    J Seyfried
    Department of Neurology, University of Tubingen, Hoppe Seyler Str 3, D 72076, Tubingen, Germany
    Eur J Pharmacol 400:155-66. 2000
    ....
  81. ncbi Improvement of paraplegia caused by spinal dural arteriovenous fistula by surgical obliteration more than 6 years after symptom onset
    O Kaut
    University of Bonn, Sigmund Freud Strasse 25, Bonn 53105, Germany
    J Neurol Neurosurg Psychiatry 79:1408-9. 2008
    ..However, even after delayed diagnosis, surgical obliteration should be done, as improvement of neurological function can still be achieved...
  82. ncbi Protocol for German trial of Acyclovir and corticosteroids in Herpes-simplex-virus-encephalitis (GACHE): a multicenter, multinational, randomized, double-blind, placebo-controlled German, Austrian and Dutch trial [ISRCTN45122933]
    Francisco Martinez-Torres
    Department of Neurology, University of Heidelberg, Germany
    BMC Neurol 8:40. 2008
    ..But currently there is no available evidence to support the routine use of adjuvant corticosteroid treatment in HSVE. A randomized multicenter trial is the only useful instrument to address this question...
  83. ncbi Creatine has no beneficial effect on skeletal muscle energy metabolism in patients with single mitochondrial DNA deletions: a placebo-controlled, double-blind 31P-MRS crossover study
    C Kornblum
    Department of Neurology, University of Bonn, Bonn, Germany
    Eur J Neurol 12:300-9. 2005
    ..Cr supplementation did not improve skeletal muscle oxidative phosphorylation in our series of patients. However, one explanation for our negative findings may be the short study duration or the limited number of patients included...
  84. ncbi Hereditary elevation of angiotensin converting enzyme suggesting neurosarcoidosis
    M Linnebank
    Klinik und Poliklinik fuer Neurologie, Universitaetsklinikum Bonn, Germany
    Neurology 61:1819-20. 2003
  85. ncbi [Brain infarct from a paradoxical embolism following a varices operation]
    M Harzheim
    Neurologische Klinik und Poliklinik, Rheinische Friedrich Wilhelms Universitat Bonn
    Dtsch Med Wochenschr 125:794-6. 2000
    ..Initially, she presented with somnolence, conjugated to the left, flexor synergism of the right extremities, exaggeration of knee and ankle jerks and extensor plantar responses on the right side...
  86. ncbi Local intra-arterial thrombolysis in the carotid territory: does recanalization depend on the thromboembolus type?
    H Urbach
    Department of Radiology Neuroradiology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Neuroradiology 44:695-9. 2002
    ..The fact that thromboembolic occlusions originating from cardiac thrombi had a lower likelihood of being resolved by thrombolysis indicates the thromboembolus type as another parameter affecting recanalization...
  87. ncbi Immunomodulatory effects of glatiramer acetate on superantigen- and mitogen-induced T-cell stimulation in vitro
    S Schmidt
    Department of Neurology, University of Bonn, Germany
    Mult Scler 8:307-9. 2002
    ....
  88. ncbi Inflammation in Parkinson's disease
    U Wullner
    Department of Neurology, University Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    J Neurol 250:I35-8. 2003
    ..Modulation of inflammatory mechanisms could provide a new neuroprotective therapy in PD...
  89. ncbi The aetiology of sporadic adult-onset ataxia
    M Abele
    Department of Neurology, University of Bonn, Germany
    Brain 125:961-8. 2002
    ..Compared with MSA, disease progression was significantly slower...
  90. ncbi Autosomal dominant familial spastic paraplegia: reduction of the FSP1 candidate region on chromosome 14q to 7 cM and locus heterogeneity
    S Gispert
    Department of Neurology, University Hospital, Dusseldorf, Germany
    Am J Hum Genet 56:183-7. 1995
    ..In pedigrees D and S, the gene locus could be excluded from the whole FSP1 region, confirming the locus heterogeneity of autosomal dominant FSP...
  91. ncbi [Diagnostic value of mitochondrial DNA analysis in chronic progressive external ophthalmoplegia (CPEO)]
    C Kornblum
    Klinik und Poliklinik fur Neurologie, Medizinische Fakultät der Universität Bonn
    Klin Monbl Augenheilkd 221:1057-61. 2004
    ..In our case only an additional molecular biological examination allowed the diagnosis of CPEO...
  92. ncbi Significantly increased prevalence of factor V Leiden in patients with dural arteriovenous fistulas
    J A Kraus
    Department of Neurology, University of Bonn Medical Center, Germany
    J Neurol 247:521-3. 2000
    ..0/22, P=0.048, Fisher's exact test). We conclude that APCR due to FV Leiden is of pathogenetic significance in a subgroup of DAVFs...
  93. ncbi Heparin-induced thrombocytopenia in neurologic disease treated with unfractionated heparin
    U Harbrecht
    Institute for Experimental Haematology and Transfusion Medicine, Rheinische Friedrich Wilhelms Universitat, Bonn, Germany
    Neurology 62:657-9. 2004
    ..Prevalence of heparin-induced antibodies was 20.5% and was dependent on heparin dose. It was higher in cerebrovascular than in noncerebrovascular (29.4% versus 11.2%, p < 0.01) patients...
  94. ncbi Sleep attacks, daytime sleepiness, and dopamine agonists in Parkinson's disease
    Sebastian Paus
    Department of Neurology, University of Bonn, Bonn, Germany
    Mov Disord 18:659-67. 2003
    ..The odds ratio for dopamine agonist therapy was 2.9 compared to 1.9 with L-dopa therapy and 1.05 for a 1-year-longer disease duration...
  95. ncbi The DRD2 TaqIA polymorphism and demand of dopaminergic medication in Parkinson's disease
    Sebastian Paus
    Department of Neurology, University of Bonn, Bonn, Germany
    Mov Disord 23:599-602. 2008
    ..We propose a practicable system of measuring dopaminergic treatment for future pharmacogenetic studies in PD...
  96. ncbi Smoking upregulates alpha4beta2* nicotinic acetylcholine receptors in the human brain
    Ullrich Wullner
    Department of Neurology, University Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Neurosci Lett 430:34-7. 2008
    ..The up-regulation of alpha4beta2* nAChR upon chronic nicotine exposure via tobacco smoking incorporates subcortical brain regions which may play an important role in nicotine addiction...
  97. ncbi The human MJD gene: genomic structure and functional characterization of the promoter region
    Ina Schmitt
    Department of Neurology, Neurobiology, University of Bonn, Sigmund Freud Str 25, 53105, Bonn, Germany
    Gene 314:81-8. 2003
    ..DNA-protein interactions defined by electrophoretic mobility shift assays (EMSA) revealed specific binding of nuclear proteins to the putative core promoter region...
  98. ncbi Dopamine transporter imaging and SPECT in diagnostic work-up of Parkinson's disease: a decision-analytic approach
    Richard C Dodel
    Department of Neurology, Friedrich Wilhelms University, Bonn, Germany
    Mov Disord 18:S52-62. 2003
    ..These results should be adjusted to the specific setting and individual patient preferences...
  99. ncbi Gene expression profiling in ataxin-3 expressing cell lines reveals distinct effects of normal and mutant ataxin-3
    Bernd O Evert
    Department of Neurology, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    J Neuropathol Exp Neurol 62:1006-18. 2003
    ....
  100. ncbi Health-related quality of life in sporadic adult-onset ataxia
    Michael Abele
    Department of Neurology, University of Bonn, Germany
    Mov Disord 22:348-52. 2007
    ..The study demonstrates a great impact of SAOA on Hr-QoL. Adequate treatment of depression, motor disability, and impaired sleep quality is essential to improve Hr-QoL in ataxic patients...
  101. ncbi Inactivation of the mouse Atxn3 (ataxin-3) gene increases protein ubiquitination
    Ina Schmitt
    Department of Neurology, University of Bonn, Neurobiology, Sigmund Freud Str 25, 53105 Bonn, Germany
    Biochem Biophys Res Commun 362:734-9. 2007
    ..Thus Atxn3 ko mice provide the first in vivo reference to the deubiquitinating activity of ATXN3...