J Klein

Summary

Affiliation: University of Mainz
Country: Germany

Publications

  1. ncbi request reprint A homeostatic mechanism counteracting K(+) -evoked choline release in adult brain
    Jochen Klein
    Department of Pharmacology, University of Mainz, Mainz, Germany
    J Neurochem 80:843-9. 2002
  2. ncbi request reprint Membrane breakdown in acute and chronic neurodegeneration: focus on choline-containing phospholipids
    J Klein
    Department of Pharmacology, University of Mainz, Federal Republic of Germany
    J Neural Transm 107:1027-63. 2000
  3. ncbi request reprint Glucose plus choline improve passive avoidance behaviour and increase hippocampal acetylcholine release in mice
    S R Kopf
    Department of Pharmacology, University of Mainz, Obere Zahlbacher Str. 67, D-55101, Mainz, Germany
    Neuroscience 103:365-71. 2001
  4. ncbi request reprint Compensatory mechanisms enhance hippocampal acetylcholine release in transgenic mice expressing human acetylcholinesterase
    C Erb
    Department of Pharmacology, University of Mainz, Mainz, Germany
    J Neurochem 77:638-46. 2001
  5. ncbi request reprint Excitotoxic hippocampal membrane breakdown and its inhibition by bilobalide: role of chloride fluxes
    J Klein
    Department of Pharmacology, Johannes Gutenberg University of Mainz, Mainz, Germany
    Pharmacopsychiatry 36:S78-83. 2003
  6. ncbi request reprint Staphylococcal alpha-toxin: repair of a calcium-impermeable pore in the target cell membrane
    A Valeva
    Institutes of Medical Microbiology and Hygiene, and Pharmacology, University of Mainz, Hochhaus am Augustusplatz, D 55101 Mainz, Germany
    Mol Microbiol 36:467-76. 2000
  7. ncbi request reprint Direct effects of ciliary neurotrophic factor on brown adipocytes: evidence for a role in peripheral regulation of energy homeostasis
    V Ott
    Department of Internal Medicine I, Medical University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    J Endocrinol 173:R1-8. 2002
  8. ncbi request reprint Direct peripheral effects of ghrelin include suppression of adiponectin expression
    V Ott
    Department of Internal Medicine I, University of Lubeck, Germany
    Horm Metab Res 34:640-5. 2002
  9. ncbi request reprint Essential role of insulin receptor substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytes
    M Fasshauer
    Research Division, Joslin Diabetes Center, and the Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    J Biol Chem 275:25494-501. 2000
  10. ncbi request reprint Central cholinergic functions in human amyloid precursor protein knock-in/presenilin-1 transgenic mice
    J Hartmann
    Alzheimer Research Group, Bayer Health Care AG, D 42096 Wuppertal, Germany
    Neuroscience 125:1009-17. 2004

Collaborators

  • A Gerber
  • U Schmitt
  • A Valeva
  • H Nawrath
  • S Bhakdi
  • H Soreq
  • C Kahn
  • V Ott
  • M Fasshauer
  • C Erb
  • A Mdzinarishvili
  • J Hartmann
  • H H Klein
  • A Dalski
  • S R Kopf
  • V Kumar
  • M Hillert
  • C Kiewert
  • G Konig
  • U Ebert
  • K H Baumann
  • A Popp
  • B Meier
  • N Perwitz
  • M Tschop
  • M L Buchholzer
  • M Hilgert
  • J Troost
  • S Kopf
  • K M Kriauciunas
  • M F White
  • M Benito
  • K Ueki

Detail Information

Publications11

  1. ncbi request reprint A homeostatic mechanism counteracting K(+) -evoked choline release in adult brain
    Jochen Klein
    Department of Pharmacology, University of Mainz, Mainz, Germany
    J Neurochem 80:843-9. 2002
    ..In adult rat brain, this elevation of Ch is counteracted by a homeostatic mechanism such as uptake into brain cells...
  2. ncbi request reprint Membrane breakdown in acute and chronic neurodegeneration: focus on choline-containing phospholipids
    J Klein
    Department of Pharmacology, University of Mainz, Federal Republic of Germany
    J Neural Transm 107:1027-63. 2000
    ..g. by combinations of choline and cytidine. Future experimental approaches should clarify whether loss of membrane phospholipids is cause or consequence of the neurodegenerative disease process...
  3. ncbi request reprint Glucose plus choline improve passive avoidance behaviour and increase hippocampal acetylcholine release in mice
    S R Kopf
    Department of Pharmacology, University of Mainz, Obere Zahlbacher Str. 67, D-55101, Mainz, Germany
    Neuroscience 103:365-71. 2001
    ..This finding reinforces the view that central cholinergic functions are influenced under certain conditions by dietary intake of precursors...
  4. ncbi request reprint Compensatory mechanisms enhance hippocampal acetylcholine release in transgenic mice expressing human acetylcholinesterase
    C Erb
    Department of Pharmacology, University of Mainz, Mainz, Germany
    J Neurochem 77:638-46. 2001
    ..Such compensatory phenomena most likely play important roles in counteracting functional deficits in mammals with central cholinergic dysfunctions...
  5. ncbi request reprint Excitotoxic hippocampal membrane breakdown and its inhibition by bilobalide: role of chloride fluxes
    J Klein
    Department of Pharmacology, Johannes Gutenberg University of Mainz, Mainz, Germany
    Pharmacopsychiatry 36:S78-83. 2003
    ..This effect is expected to contribute to the neuroprotective effects of ginkgo biloba extracts...
  6. ncbi request reprint Staphylococcal alpha-toxin: repair of a calcium-impermeable pore in the target cell membrane
    A Valeva
    Institutes of Medical Microbiology and Hygiene, and Pharmacology, University of Mainz, Hochhaus am Augustusplatz, D 55101 Mainz, Germany
    Mol Microbiol 36:467-76. 2000
    ..Our findings reveal the existence of a novel mechanism of membrane repair that may consist in constriction of the inserted proteinaceous pore within the lipid bilayer...
  7. ncbi request reprint Direct effects of ciliary neurotrophic factor on brown adipocytes: evidence for a role in peripheral regulation of energy homeostasis
    V Ott
    Department of Internal Medicine I, Medical University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    J Endocrinol 173:R1-8. 2002
    ..Thus, these results demonstrate direct effects of CNTF on adipose tissue signalling and metabolism and suggest a novel role for this cytokine in the peripheral regulation of energy homeostasis...
  8. ncbi request reprint Direct peripheral effects of ghrelin include suppression of adiponectin expression
    V Ott
    Department of Internal Medicine I, University of Lubeck, Germany
    Horm Metab Res 34:640-5. 2002
    ..In summary, our data provide evidence for selective effects of ghrelin on adipocyte signaling and function and thus propose a role for adipose tissue as a novel mediator of ghrelin's effects on energy balance and glucose homeostasis...
  9. ncbi request reprint Essential role of insulin receptor substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytes
    M Fasshauer
    Research Division, Joslin Diabetes Center, and the Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    J Biol Chem 275:25494-501. 2000
    ..This occurs without effects in differentiation, total activation of Akt and its downstream effectors, but may be caused by alterations in compartmentalization of these downstream signals...
  10. ncbi request reprint Central cholinergic functions in human amyloid precursor protein knock-in/presenilin-1 transgenic mice
    J Hartmann
    Alzheimer Research Group, Bayer Health Care AG, D 42096 Wuppertal, Germany
    Neuroscience 125:1009-17. 2004
    ..The deposition of amyloid plaques, however, does not impair stimulated ACh release and proceeds without major changes of central cholinergic function...
  11. ncbi request reprint Bilobalide prevents ischemia-induced edema formation in vitro and in vivo
    A Mdzinarishvili
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Science Center, 1300 Coulter Drive, Amarillo, TX 79106, USA
    Neuroscience 144:217-22. 2007
    ..Bilobalide may be therapeutically effective in brain edema which occurs secondarily to large hemispheric stroke and traumatic brain injury in humans...