Christoph A Klein

Summary

Affiliation: University of Regensburg
Country: Germany

Publications

  1. ncbi request reprint The systemic progression of human cancer: a focus on the individual disseminated cancer cell--the unit of selection
    Christoph A Klein
    Institut fur Immunologie, Ludwig Maximilians Universitat Munchen, Goethestr 31, 80336 Munchen, Germany
    Adv Cancer Res 89:35-67. 2003
  2. ncbi request reprint Gene expression sigantures, cancer cell evolution and metastatic progression
    Christoph A Klein
    Institut fur Immunologie, Ludwig Maximilians Universität Munchen Goethestr 31, 80336 Munchen, Germany
    Cell Cycle 3:29-31. 2004
  3. ncbi request reprint Single cell amplification methods for the study of cancer and cellular ageing
    Christoph A Klein
    Institut für Immunologie der Ludwigs Maximilian Universität München, München 80336, Germany
    Mech Ageing Dev 126:147-51. 2005
  4. doi request reprint Cancer. The metastasis cascade
    Christoph A Klein
    Division of Oncogenomics, Department of Pathology, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Science 321:1785-7. 2008
  5. doi request reprint Parallel progression of primary tumours and metastases
    Christoph A Klein
    Division of Oncogenomics, Department of Pathology, University of Regensburg, 93053 Regensburg, Germany
    Nat Rev Cancer 9:302-12. 2009
  6. pmc Stromal upregulation of lateral epithelial adhesions: gene expression analysis of signalling pathways in prostate epithelium
    Karen F Chambers
    Yorkshire Cancer Research Unit, Dept, Biology, University of York, Heslington, York YO10 5YW, UK
    J Biomed Sci 18:45. 2011
  7. doi request reprint Lessons from an aggressive cancer: evolutionary dynamics in esophageal carcinoma
    Christoph A Klein
    Department of Pathology, Division of Oncogenomics, University of Regensburg, Regensburg, Germany
    Cancer Res 69:5285-8. 2009
  8. doi request reprint The direct molecular analysis of metastatic precursor cells in breast cancer: a chance for a better understanding of metastasis and for personalised medicine
    Christoph A Klein
    Division of Oncogenomics, Department of Pathology, University of Regensburg, Regensburg, Germany
    Eur J Cancer 44:2721-5. 2008
  9. pmc Random mutations, selected mutations: A PIN opens the door to new genetic landscapes
    Christoph A Klein
    Department of Pathology, Division of Oncogenomics, University of Regensburg, 93053 Regensburg, Germany
    Proc Natl Acad Sci U S A 103:18033-4. 2006
  10. doi request reprint Systemic spread is an early step in breast cancer
    Yves Hüsemann
    Department of Pathology, Division of Oncogenomics, University of Regensburg, Regensburg 93053, Germany
    Cancer Cell 13:58-68. 2008

Collaborators

  • Nikolas H Stoecklein
  • Wulf Sienel
  • Yves Hüsemann
  • Bernward Passlick
  • Roland Eils
  • Guido Forni
  • Andreas Erbersdobler
  • Tanja Fehm
  • Peter Scheunemann
  • H Joensuu
  • Pablo E Verde
  • V L Kinnula
  • Rudolf M Huber
  • Elena Sarropoulou
  • Oleg Schmidt-Kittler
  • Beatrix Cucuruz
  • Karen F Chambers
  • Sonja Hahtola
  • Christine Fuhrmann
  • Thomas Ragg
  • Xiao Tao Wang
  • Anja Ulmer
  • Gert Riethmuller
  • Nikolaus Freudenberg
  • Sebastian Dango
  • Marie Follo
  • Olga Mayer
  • Joachim Böhm
  • Vindi Jurinovic
  • Bernhard Polzer
  • Mirjam Elze
  • Miodrag Guzvić
  • Naveed Aziz
  • Shona H Lang
  • Joanna F Pearson
  • Davide Pellacani
  • Leila Jeskanen
  • Christian Vay
  • Marjut Puputti
  • Leena Karenko
  • Paivi Peltomaki
  • Elke Burghart
  • Susanna Virolainen
  • Karina Petat-Dutter
  • Annamari Ranki
  • Wael M Abdel-Rahman
  • Richard Reinhardt
  • Liisa Väkevä
  • Kaisa Salmenkivi
  • Kerstin Bockler
  • Jaakko Karvonen
  • Corina Ludwig
  • Erich Stoelben
  • Johannes Mueller
  • Stephan Eggeling
  • Jorg Fischer
  • Ulf Ellwanger
  • Gerhard Fierlbeck
  • Gernot Rassner
  • Angela Daskalakis
  • Andre Ahr
  • Peter Muller
  • Joachim Diebold
  • Detlev Harich
  • Thomas J F Blankenstein
  • Hans Arnholdt
  • Martin Granzow
  • Joachim Bischoff
  • Manfred Kaufmann
  • Gunter Schlimok

Detail Information

Publications25

  1. ncbi request reprint The systemic progression of human cancer: a focus on the individual disseminated cancer cell--the unit of selection
    Christoph A Klein
    Institut fur Immunologie, Ludwig Maximilians Universitat Munchen, Goethestr 31, 80336 Munchen, Germany
    Adv Cancer Res 89:35-67. 2003
    ..This review integrates data derived by different approaches into a model of systemic cancer progression...
  2. ncbi request reprint Gene expression sigantures, cancer cell evolution and metastatic progression
    Christoph A Klein
    Institut fur Immunologie, Ludwig Maximilians Universität Munchen Goethestr 31, 80336 Munchen, Germany
    Cell Cycle 3:29-31. 2004
    ....
  3. ncbi request reprint Single cell amplification methods for the study of cancer and cellular ageing
    Christoph A Klein
    Institut für Immunologie der Ludwigs Maximilian Universität München, München 80336, Germany
    Mech Ageing Dev 126:147-51. 2005
    ..Our results emphasize the importance to study age-related diseases such as cancer on the level of single cells...
  4. doi request reprint Cancer. The metastasis cascade
    Christoph A Klein
    Division of Oncogenomics, Department of Pathology, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Science 321:1785-7. 2008
  5. doi request reprint Parallel progression of primary tumours and metastases
    Christoph A Klein
    Division of Oncogenomics, Department of Pathology, University of Regensburg, 93053 Regensburg, Germany
    Nat Rev Cancer 9:302-12. 2009
    ..Consideration of this model urges review of current diagnostic and therapeutic routines...
  6. pmc Stromal upregulation of lateral epithelial adhesions: gene expression analysis of signalling pathways in prostate epithelium
    Karen F Chambers
    Yorkshire Cancer Research Unit, Dept, Biology, University of York, Heslington, York YO10 5YW, UK
    J Biomed Sci 18:45. 2011
    ..Stromal signalling increases the lateral cell adhesions of prostate epithelial cells grown in 3D culture. The aim of this study was to use microarray analysis to identify significant epithelial signalling pathways and genes in this process...
  7. doi request reprint Lessons from an aggressive cancer: evolutionary dynamics in esophageal carcinoma
    Christoph A Klein
    Department of Pathology, Division of Oncogenomics, University of Regensburg, Regensburg, Germany
    Cancer Res 69:5285-8. 2009
    ..These findings have implications for diagnostic pathology and therapeutic decision making...
  8. doi request reprint The direct molecular analysis of metastatic precursor cells in breast cancer: a chance for a better understanding of metastasis and for personalised medicine
    Christoph A Klein
    Division of Oncogenomics, Department of Pathology, University of Regensburg, Regensburg, Germany
    Eur J Cancer 44:2721-5. 2008
    ....
  9. pmc Random mutations, selected mutations: A PIN opens the door to new genetic landscapes
    Christoph A Klein
    Department of Pathology, Division of Oncogenomics, University of Regensburg, 93053 Regensburg, Germany
    Proc Natl Acad Sci U S A 103:18033-4. 2006
  10. doi request reprint Systemic spread is an early step in breast cancer
    Yves Hüsemann
    Department of Pathology, Division of Oncogenomics, University of Regensburg, Regensburg 93053, Germany
    Cancer Cell 13:58-68. 2008
    ..Therefore, release from dormancy of early-disseminated cancer cells may frequently account for metachronous metastasis...
  11. doi request reprint Selection and adaptation during metastatic cancer progression
    Christoph A Klein
    Experimental Medicine and Therapy Research, University of Regensburg, Regensburg, Germany
    Nature 501:365-72. 2013
    ..Abrogation of the cells' progression outside the primary tumour implies new challenges and opportunities for diagnosis and adjuvant therapies. ..
  12. doi request reprint MAGE qPCR improves the sensitivity and accuracy of EBUS-TBNA for the detection of lymphatic cancer spread
    Beatrix Cucuruz
    Department of Pathology, University of Regensburg, Regensburg, Germany
    J Thorac Oncol 7:690-7. 2012
    ..Therefore, we explored whether the detection of tumor-associated mRNA in lymph node samples from patients with suspected lung cancer adds diagnostic accuracy to conventional histopathological staging...
  13. doi request reprint The analysis of metastasis in transgenic mouse models
    Yves Hüsemann
    Department of Pathology, University of Regensburg, Franz Josef Strauss Allee 11, 93053, Regensburg, Germany
    Transgenic Res 18:1-5. 2009
    ....
  14. doi request reprint Direct genetic analysis of single disseminated cancer cells for prediction of outcome and therapy selection in esophageal cancer
    Nikolas H Stoecklein
    Department of Pathology, Division of Oncogenomics, University of Regensburg, D 93053 Regensburg, Germany
    Cancer Cell 13:441-53. 2008
    ..Survival analysis demonstrated that HER2 gain in a single disseminated tumor cell but not in primary tumors conferred high risk for early death...
  15. pmc High-resolution array comparative genomic hybridization of single micrometastatic tumor cells
    Christine Fuhrmann
    Division of Oncogenomics, Department of Pathology, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Nucleic Acids Res 36:e39. 2008
    ..4 and 5 Mb. Thus, high-resolution genome analysis of single metastatic precursor cells is now possible and may be used for the identification of novel therapy target genes...
  16. doi request reprint Framework models of tumor dormancy from patient-derived observations
    Christoph A Klein
    Experimental Medicine and Therapy Research, Department of Pathology, University of Regensburg, 93053 Regensburg, Germany
    Curr Opin Genet Dev 21:42-9. 2011
    ..This review attempts to provide a conceptual framework for the study of dormancy, which may guide clinical and experimental research...
  17. pmc From latent disseminated cells to overt metastasis: genetic analysis of systemic breast cancer progression
    Oleg Schmidt-Kittler
    Institut fur Immunologie, Ludwig Maximilians Universitat Munchen, 80336 Munchen, Germany
    Proc Natl Acad Sci U S A 100:7737-42. 2003
    ..Thus, our data challenge the widely held view that the precursors of metastasis are derived from the most advanced clone within the primary tumor...
  18. ncbi request reprint Genetic heterogeneity of single disseminated tumour cells in minimal residual cancer
    Christoph A Klein
    Institut fur Immunologie, Ludwig Maximilians Universitat Munchen, D 80336 MUnchen, Germany
    Lancet 360:683-9. 2002
    ..Disseminated tumour cells can be detected by epithelial markers in mesenchymal tissues and represent targets for adjuvant therapies...
  19. ncbi request reprint Detection of disseminated tumor cells in mediastinoscopic lymph node biopsies and lymphadenectomy specimens of patients with NSCLC by quantitative RT-PCR
    Xiao Tao Wang
    Department of Thoracic Surgery, Albert Ludwigs University Freiburg, Hugstetter Str 55, 79106 Freiburg, Germany
    Eur J Cardiothorac Surg 28:26-32. 2005
    ..This prospective study was performed to evaluate a simple and observer-independent polymerase chain reaction (PCR)-based method for the detection of disseminated tumor cells in regional lymph nodes...
  20. ncbi request reprint Immunomagnetic enrichment, genomic characterization, and prognostic impact of circulating melanoma cells
    Anja Ulmer
    Universitäts Hautklinik, Eberhard Karls Universitat, Tubingen, Germany
    Clin Cancer Res 10:531-7. 2004
    ..To address this question, we analyzed immunomagnetically isolated circulating melanoma cells for chromosomal aberrations and performed a clinical follow-up study of the enrolled patients...
  21. doi request reprint Cellular localization of EMMPRIN predicts prognosis of patients with operable lung adenocarcinoma independent from MMP-2 and MMP-9
    Wulf Sienel
    Department of Thoracic Surgery, University Hospital Freiburg, Freiburg, Germany
    Mod Pathol 21:1130-8. 2008
    ..04; Cox regression analysis). The findings point to a role of EMMPRIN for the progression of adenocarcinoma of the lung that is unrelated to its function as inducer of MMPs...
  22. ncbi request reprint Copy number of chromosome 17 but not HER2 amplification predicts clinical outcome of patients with pancreatic ductal adenocarcinoma
    Nikolas H Stoecklein
    Chirurgische Klinik, and Institut für Pathologie, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    J Clin Oncol 22:4737-45. 2004
    ..To determine the frequency and the potential clinical use of HER2 (17q21) gene amplification and chromosome 17 aneuploidy in pancreatic ductal adenocarcinoma (PDAC)...
  23. ncbi request reprint Cutaneous T-cell lymphoma-associated lung cancers show chromosomal aberrations differing from primary lung cancer
    Sonja Hahtola
    Department of Dermatology and Allergology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Genes Chromosomes Cancer 47:107-17. 2008
    ..These preliminary observations warrant further prospective studies to identify the common underlying factors between CTCL and CTCL-associated lung cancer...
  24. ncbi request reprint Systemic cancer progression and tumor dormancy: mathematical models meet single cell genomics
    Christoph A Klein
    Institut fur Immunologie, Ludwig Maximilians Universitat, Munchen, Germany
    Cell Cycle 5:1788-98. 2006
    ....
  25. ncbi request reprint Combined transcriptome and genome analysis of single micrometastatic cells
    Christoph A Klein
    Institut fur Immunologie, Ludwig Maximilians Universitat Munchen, D 80336 Munich, Germany
    Nat Biotechnol 20:387-92. 2002
    ....