Christoph A Klein
Affiliation: University of Regensburg
- The systemic progression of human cancer: a focus on the individual disseminated cancer cell--the unit of selectionChristoph A Klein
, , Goethestr 31, , Germany
Adv Cancer Res 89:35-67. 2003..This review integrates data derived by different approaches into a model of systemic cancer progression...
- Gene expression sigantures, cancer cell evolution and metastatic progressionChristoph A Klein
Institut fur Immunologie, Ludwig Maximilians Universität Munchen Goethestr 31, 80336 Munchen, Germany
Cell Cycle 3:29-31. 2004....
- Single cell amplification methods for the study of cancer and cellular ageingChristoph A Klein
Institut für Immunologie der Ludwigs Maximilian Universität München, München 80336, Germany
Mech Ageing Dev 126:147-51. 2005..Our results emphasize the importance to study age-related diseases such as cancer on the level of single cells...
- Cancer. The metastasis cascadeChristoph A Klein
Division of Oncogenomics, Department of Pathology, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany
Science 321:1785-7. 2008
- Parallel progression of primary tumours and metastasesChristoph A Klein
Division of Oncogenomics, Department of Pathology, University of Regensburg, 93053 Regensburg, Germany
Nat Rev Cancer 9:302-12. 2009..Consideration of this model urges review of current diagnostic and therapeutic routines...
- Stromal upregulation of lateral epithelial adhesions: gene expression analysis of signalling pathways in prostate epitheliumKaren F Chambers
Yorkshire Cancer Research Unit, Dept, Biology, University of York, Heslington, York YO10 5YW, UK
J Biomed Sci 18:45. 2011..Stromal signalling increases the lateral cell adhesions of prostate epithelial cells grown in 3D culture. The aim of this study was to use microarray analysis to identify significant epithelial signalling pathways and genes in this process...
- Lessons from an aggressive cancer: evolutionary dynamics in esophageal carcinomaChristoph A Klein
Department of Pathology, Division of Oncogenomics, University of Regensburg, Regensburg, Germany
Cancer Res 69:5285-8. 2009..These findings have implications for diagnostic pathology and therapeutic decision making...
- The direct molecular analysis of metastatic precursor cells in breast cancer: a chance for a better understanding of metastasis and for personalised medicineChristoph A Klein
Division of Oncogenomics, Department of Pathology, University of Regensburg, Regensburg, Germany
Eur J Cancer 44:2721-5. 2008....
- Random mutations, selected mutations: A PIN opens the door to new genetic landscapesChristoph A Klein
Department of Pathology, Division of Oncogenomics, University of Regensburg, 93053 Regensburg, Germany
Proc Natl Acad Sci U S A 103:18033-4. 2006
- Systemic spread is an early step in breast cancerYves Hüsemann
Department of Pathology, Division of Oncogenomics, University of Regensburg, Regensburg 93053, Germany
Cancer Cell 13:58-68. 2008..Therefore, release from dormancy of early-disseminated cancer cells may frequently account for metachronous metastasis...
- MAGE qPCR improves the sensitivity and accuracy of EBUS-TBNA for the detection of lymphatic cancer spreadBeatrix Cucuruz
Department of Pathology, University of Regensburg, Regensburg, Germany
J Thorac Oncol 7:690-7. 2012..Therefore, we explored whether the detection of tumor-associated mRNA in lymph node samples from patients with suspected lung cancer adds diagnostic accuracy to conventional histopathological staging...
- High-resolution array comparative genomic hybridization of single micrometastatic tumor cellsChristine Fuhrmann
Division of Oncogenomics, Department of Pathology, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
Nucleic Acids Res 36:e39. 2008..4 and 5 Mb. Thus, high-resolution genome analysis of single metastatic precursor cells is now possible and may be used for the identification of novel therapy target genes...
- Direct genetic analysis of single disseminated cancer cells for prediction of outcome and therapy selection in esophageal cancerNikolas H Stoecklein
Department of Pathology, Division of Oncogenomics, University of Regensburg, D 93053 Regensburg, Germany
Cancer Cell 13:441-53. 2008..Survival analysis demonstrated that HER2 gain in a single disseminated tumor cell but not in primary tumors conferred high risk for early death...
- The analysis of metastasis in transgenic mouse modelsYves Hüsemann
Department of Pathology, University of Regensburg, Franz Josef Strauss Allee 11, 93053, Regensburg, Germany
Transgenic Res 18:1-5. 2009....
- Framework models of tumor dormancy from patient-derived observationsChristoph A Klein
Experimental Medicine and Therapy Research, Department of Pathology, University of Regensburg, 93053 Regensburg, Germany
Curr Opin Genet Dev 21:42-9. 2011..This review attempts to provide a conceptual framework for the study of dormancy, which may guide clinical and experimental research...
- Detection of disseminated tumor cells in mediastinoscopic lymph node biopsies and lymphadenectomy specimens of patients with NSCLC by quantitative RT-PCRXiao Tao Wang
Department of Thoracic Surgery, Albert-Ludwigs-University Freiburg, Hugstetter Str. 55, 79106 Freiburg, Germany
Eur J Cardiothorac Surg 28:26-32. 2005..Further studies are required to asses if this molecular method might improve mediastinoscopic staging...
- Genetic heterogeneity of single disseminated tumour cells in minimal residual cancerChristoph A Klein
Institut fur Immunologie, Ludwig Maximilians Universitat Munchen, D 80336 MUnchen, Germany
Lancet 360:683-9. 2002..Disseminated tumour cells can be detected by epithelial markers in mesenchymal tissues and represent targets for adjuvant therapies...
- From latent disseminated cells to overt metastasis: genetic analysis of systemic breast cancer progressionOleg Schmidt-Kittler
, , , Germany
Proc Natl Acad Sci U S A 100:7737-42. 2003..Thus, our data challenge the widely held view that the precursors of metastasis are derived from the most advanced clone within the primary tumor...
- Immunomagnetic enrichment, genomic characterization, and prognostic impact of circulating melanoma cellsAnja Ulmer
, , , Germany
Clin Cancer Res 10:531-7. 2004..Direct genomic analysis of the enriched and isolated cells will help to clarify the molecular-genetic basis of the establishment of generalized melanoma...
- Cellular localization of EMMPRIN predicts prognosis of patients with operable lung adenocarcinoma independent from MMP-2 and MMP-9Wulf Sienel
Department of Thoracic Surgery, University Hospital Freiburg, Freiburg, Germany
Mod Pathol 21:1130-8. 2008..04; Cox regression analysis). The findings point to a role of EMMPRIN for the progression of adenocarcinoma of the lung that is unrelated to its function as inducer of MMPs...
- Copy number of chromosome 17 but not HER2 amplification predicts clinical outcome of patients with pancreatic ductal adenocarcinomaNikolas H Stoecklein
Chirurgische Klinik, and Institut für Pathologie, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
J Clin Oncol 22:4737-45. 2004..To determine the frequency and the potential clinical use of HER2 (17q21) gene amplification and chromosome 17 aneuploidy in pancreatic ductal adenocarcinoma (PDAC)...
- Cutaneous T-cell lymphoma-associated lung cancers show chromosomal aberrations differing from primary lung cancerSonja Hahtola
Department of Dermatology and Allergology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
Genes Chromosomes Cancer 47:107-17. 2008..These preliminary observations warrant further prospective studies to identify the common underlying factors between CTCL and CTCL-associated lung cancer...
- Systemic cancer progression and tumor dormancy: mathematical models meet single cell genomicsChristoph A Klein
Institut fur Immunologie, Ludwig Maximilians Universitat, Munchen, Germany
Cell Cycle 5:1788-98. 2006....
- Combined transcriptome and genome analysis of single micrometastatic cellsChristoph A Klein
Institut fur Immunologie, Ludwig Maximilians Universitat Munchen, D 80336 Munich, Germany
Nat Biotechnol 20:387-92. 2002....