Andreas R Klatt

Summary

Affiliation: University of Cologne
Country: Germany

Publications

  1. doi The matrilin-3 VWA1 domain modulates interleukin-6 release from primary human chondrocytes
    A R Klatt
    Institute for Clinical Chemistry, University of Cologne, Cologne, Germany
    Osteoarthritis Cartilage 21:869-73. 2013
  2. ncbi RNAi in primary human chondrocytes: efficiencies, kinetics, and non-specific effects of siRNA-mediated gene suppression
    Andreas R Klatt
    Institute of Clinical Chemistry, University of Cologne, Kerpener Strasse 62, 50924 Köln, Germany
    Biologicals 35:321-8. 2007
  3. doi A critical role for collagen II in cartilage matrix degradation: collagen II induces pro-inflammatory cytokines and MMPs in primary human chondrocytes
    Andreas R Klatt
    Institute for Clinical Chemistry, University of Cologne, Koln, Germany
    J Orthop Res 27:65-70. 2009
  4. doi Discoidin domain receptor 2 mediates the collagen II-dependent release of interleukin-6 in primary human chondrocytes
    Andreas R Klatt
    Institute for Clinical Chemistry, University of Cologne, Germany
    J Pathol 218:241-7. 2009
  5. doi Matrilin-3 activates the expression of osteoarthritis-associated genes in primary human chondrocytes
    Andreas R Klatt
    Institute for Clinical Chemistry, University of Cologne, Germany
    FEBS Lett 583:3611-7. 2009
  6. doi TAK1 mediates the collagen-II-dependent induction of the COX-2 gene and PGE2 release in primary human chondrocytes
    Andreas R Klatt
    Institute for Clinical Chemistry, University of Cologne, Cologne, Germany
    Connect Tissue Res 51:452-8. 2010
  7. pmc Proteolytic processing causes extensive heterogeneity of tissue matrilin forms
    Harald W A Ehlen
    Center for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany
    J Biol Chem 284:21545-56. 2009
  8. ncbi TAK1 downregulation reduces IL-1beta induced expression of MMP13, MMP1 and TNF-alpha
    Andreas R Klatt
    Institut fur Klinische Chemie, University of Cologne, Germany
    Biomed Pharmacother 60:55-61. 2006
  9. doi The matrilins: modulators of extracellular matrix assembly
    Andreas R Klatt
    Institute for Clinical Chemistry, University of Cologne, Germany
    Int J Biochem Cell Biol 43:320-30. 2011
  10. ncbi Expression of matrilins during maturation of mouse skeletal tissues
    Andreas R Klatt
    Institute for Biochemistry II, Medical Faculty, University of Cologne, Joseph Stelzmann Str 52, D 50931 Cologne, Germany
    Matrix Biol 21:289-96. 2002

Collaborators

  • Wibke Johannis
  • R Wagener
  • Stefan Muller
  • T Aigner
  • Johannes Ruthard
  • Harald W A Ehlen
  • Mats Paulsson
  • Charlotte Wiberg
  • Stefan Höllriegl
  • Frank Zaucke
  • Jörg H Renno
  • Gertrud Kühn
  • Matthias Kamper
  • Ute Hillebrand
  • Anja Talke
  • Gerhard Sengle
  • Dick Heinegard
  • Matthias Morgelin
  • John F Bateman

Detail Information

Publications13

  1. doi The matrilin-3 VWA1 domain modulates interleukin-6 release from primary human chondrocytes
    A R Klatt
    Institute for Clinical Chemistry, University of Cologne, Cologne, Germany
    Osteoarthritis Cartilage 21:869-73. 2013
    ..Here, we investigated the potential of matrilin-3 (MATN3) and truncated matrilin-3 proteins, in both monomeric and oligomeric form, to stimulate interleukin (IL)-6 release in PHCs...
  2. ncbi RNAi in primary human chondrocytes: efficiencies, kinetics, and non-specific effects of siRNA-mediated gene suppression
    Andreas R Klatt
    Institute of Clinical Chemistry, University of Cologne, Kerpener Strasse 62, 50924 Köln, Germany
    Biologicals 35:321-8. 2007
    ..Hence, it is essential to analyze and to compare gene silencing siRNAs and control siRNAs with respect to their off-target effects prior to any functional gene validation...
  3. doi A critical role for collagen II in cartilage matrix degradation: collagen II induces pro-inflammatory cytokines and MMPs in primary human chondrocytes
    Andreas R Klatt
    Institute for Clinical Chemistry, University of Cologne, Koln, Germany
    J Orthop Res 27:65-70. 2009
    ..This, in turn, induces more pro-inflammatory cytokines and MMPs, and the process is repeated, which results in the acceleration and perpetuation of cartilage matrix degradation...
  4. doi Discoidin domain receptor 2 mediates the collagen II-dependent release of interleukin-6 in primary human chondrocytes
    Andreas R Klatt
    Institute for Clinical Chemistry, University of Cologne, Germany
    J Pathol 218:241-7. 2009
    ..Given the detrimental role of these molecules in osteoarthritis, our findings provide new targets for more specific therapeutics, which may have fewer side effects than those currently applied...
  5. doi Matrilin-3 activates the expression of osteoarthritis-associated genes in primary human chondrocytes
    Andreas R Klatt
    Institute for Clinical Chemistry, University of Cologne, Germany
    FEBS Lett 583:3611-7. 2009
    ..ADAMTS4 and ADAMTS5, in turn, cleave matrilin-3 and may release more matrilin-3 from the matrix, which could lead to further release of pro-inflammatory cytokines and proteases in cartilage...
  6. doi TAK1 mediates the collagen-II-dependent induction of the COX-2 gene and PGE2 release in primary human chondrocytes
    Andreas R Klatt
    Institute for Clinical Chemistry, University of Cologne, Cologne, Germany
    Connect Tissue Res 51:452-8. 2010
    ..These findings are promising in that therapeutic inhibition of TAK1 might be used to reduce pain and relieve inflammatory symptoms that are common in osteoarthritis...
  7. pmc Proteolytic processing causes extensive heterogeneity of tissue matrilin forms
    Harald W A Ehlen
    Center for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany
    J Biol Chem 284:21545-56. 2009
    ....
  8. ncbi TAK1 downregulation reduces IL-1beta induced expression of MMP13, MMP1 and TNF-alpha
    Andreas R Klatt
    Institut fur Klinische Chemie, University of Cologne, Germany
    Biomed Pharmacother 60:55-61. 2006
    ....
  9. doi The matrilins: modulators of extracellular matrix assembly
    Andreas R Klatt
    Institute for Clinical Chemistry, University of Cologne, Germany
    Int J Biochem Cell Biol 43:320-30. 2011
    ....
  10. ncbi Expression of matrilins during maturation of mouse skeletal tissues
    Andreas R Klatt
    Institute for Biochemistry II, Medical Faculty, University of Cologne, Joseph Stelzmann Str 52, D 50931 Cologne, Germany
    Matrix Biol 21:289-96. 2002
    ..During joint development matrilin-2 and matrilin-4 are present at the developing joint surface, while in articular cartilage of 6-week-old mice all matrilins are only weakly expressed...
  11. doi COMP does not directly modify the expression of genes involved in cartilage homeostasis in contrast to several other cartilage matrix proteins
    Johannes Ruthard
    Institute for Clinical Chemistry, University of Cologne, Cologne, Germany
    Connect Tissue Res 55:348-56. 2014
    ..We investigated whether COMP may modify cartilage metabolism and play a role as an endogenous disease aggravating factor in OA...
  12. pmc Gamma heavy chain disease in a patient with rheumatoid arthritis--a laboratory evaluation
    Wibke Johannis
    Institute for Clinical Chemistry, University Hospital of Cologne, Koeln, Germany
    Biochem Med (Zagreb) 22:373-9. 2012
    ..Being rare and probably underdiagnosed diseases the aim of this report is to show an additional case of gamma heavy chain disease in a 48 year old female patient with rheumatoid arthritis focusing on the laboratory presentation...
  13. ncbi Complexes of matrilin-1 and biglycan or decorin connect collagen VI microfibrils to both collagen II and aggrecan
    Charlotte Wiberg
    Department of Cell and Molecular Biology, University of Lund, BMC, S 221 84 Lund, Sweden
    J Biol Chem 278:37698-704. 2003
    ..Colocalization of collagen VI and the different ligands in the pericellular matrix of cultured chondrosarcoma cells supported the physiological relevance of the observed interactions in matrix assembly...