Timo Kirschstein

Summary

Affiliation: University of Rostock
Country: Germany

Publications

  1. ncbi request reprint What is the source of the EEG?
    Timo Kirschstein
    Institute of Physiology, University of Rostock, Germany
    Clin EEG Neurosci 40:146-9. 2009
  2. pmc ZD7288 enhances long-term depression at early postnatal medial perforant path-granule cell synapses
    Xiati Guli
    Oscar Langendorff Institute of Physiology, University of Rostock, 18057 Rostock, Germany
    Neural Plast 2012:237913. 2012
  3. pmc Synaptic plasticity and learning in animal models of tuberous sclerosis complex
    Timo Kirschstein
    Oscar Langendorff Institute of Physiology, University of Rostock, Gertrudenstrasse 9, 18057 Rostock, Germany
    Neural Plast 2012:279834. 2012
  4. doi request reprint The 27-kDa heat shock protein (HSP27) is a reliable hippocampal marker of full development of pilocarpine-induced status epilepticus
    Timo Kirschstein
    Oscar Langendorff Institute of Physiology, Medical Faculty, University of Rostock, Gertrudenstrasse 9, 18057 Rostock, Germany
    Epilepsy Res 98:35-43. 2012
  5. doi request reprint Dopamine induces contraction in the proximal, but relaxation in the distal rat isolated small intestine
    Timo Kirschstein
    Institute of Physiology, University of Rostock, Gertrudenstrasse 9, 18057 Rostock, Germany
    Neurosci Lett 465:21-6. 2009
  6. ncbi request reprint Loss of metabotropic glutamate receptor-dependent long-term depression via downregulation of mGluR5 after status epilepticus
    Timo Kirschstein
    Department of Epileptology, University of Bonn, D 53105 Bonn, Germany
    J Neurosci 27:7696-704. 2007
  7. pmc High K+-induced contraction requires depolarization-induced Ca2+ release from internal stores in rat gut smooth muscle
    Timo Kirschstein
    Institute of Physiology, University of Rostock, Gertrudenstrasse 9, 18055 Rostock, Germany
    Acta Pharmacol Sin 30:1123-31. 2009
  8. ncbi request reprint HCN1 channels constrain DHPG-induced LTD at hippocampal Schaffer collateral-CA1 synapses
    Tursonjan Tokay
    Institute of Physiology, University of Rostock, 18055 Rostock, Germany
    Learn Mem 16:769-76. 2009
  9. ncbi request reprint GABA(A) receptor inhibition does not affect mGluR-dependent LTD at hippocampal Schaffer collateral-CA1 synapses
    Marco Rohde
    Institute of Physiology, University of Rostock, Gertrudenstrasse 9, 18057 Rostock, Germany
    Neurosci Lett 467:20-5. 2009
  10. doi request reprint Impaired D-serine-mediated cotransmission mediates cognitive dysfunction in epilepsy
    Katharina Klatte
    Laboratory of Experimental Epileptology, Department of Epileptology and Institute of Molecular Psychiatry, University of Bonn, D 53127 Bonn, Germany
    J Neurosci 33:13066-80. 2013

Collaborators

Detail Information

Publications26

  1. ncbi request reprint What is the source of the EEG?
    Timo Kirschstein
    Institute of Physiology, University of Rostock, Germany
    Clin EEG Neurosci 40:146-9. 2009
    ..Negative (upward) deflections are due to superficial excitatory or deep inhibitory inputs, whereas positive (downward) deflections represent deep excitatory or superficial inhibitory inputs...
  2. pmc ZD7288 enhances long-term depression at early postnatal medial perforant path-granule cell synapses
    Xiati Guli
    Oscar Langendorff Institute of Physiology, University of Rostock, 18057 Rostock, Germany
    Neural Plast 2012:237913. 2012
    ..In conclusion, we found that HCN channels at the medial perforant path-granule cell synapse compromise LFS-associated induction, but not expression of LTD in early postnatal, but not in adult, rats...
  3. pmc Synaptic plasticity and learning in animal models of tuberous sclerosis complex
    Timo Kirschstein
    Oscar Langendorff Institute of Physiology, University of Rostock, Gertrudenstrasse 9, 18057 Rostock, Germany
    Neural Plast 2012:279834. 2012
    ..A special focus will be laid on differences among these models, which may be in part due to different background strains, but also may indicate pathophysiological variation in different mutations...
  4. doi request reprint The 27-kDa heat shock protein (HSP27) is a reliable hippocampal marker of full development of pilocarpine-induced status epilepticus
    Timo Kirschstein
    Oscar Langendorff Institute of Physiology, Medical Faculty, University of Rostock, Gertrudenstrasse 9, 18057 Rostock, Germany
    Epilepsy Res 98:35-43. 2012
    ..Since not all animals enter SE following pilocarpine injection, we aimed to find a biomarker for full development of pilocarpine-induced SE using a proteomic approach...
  5. doi request reprint Dopamine induces contraction in the proximal, but relaxation in the distal rat isolated small intestine
    Timo Kirschstein
    Institute of Physiology, University of Rostock, Gertrudenstrasse 9, 18057 Rostock, Germany
    Neurosci Lett 465:21-6. 2009
    ..In proximal parts, dopamine predominantly causes D(1) and D(2) dopamine receptor-dependent contraction, whereas it leads to alpha and beta adrenoceptor-dependent relaxation in more distal parts...
  6. ncbi request reprint Loss of metabotropic glutamate receptor-dependent long-term depression via downregulation of mGluR5 after status epilepticus
    Timo Kirschstein
    Department of Epileptology, University of Bonn, D 53105 Bonn, Germany
    J Neurosci 27:7696-704. 2007
    ..Thus, we conclude that the reduction of mGluR LTD after pilocarpine-induced status epilepticus is the result of the subtype-specific downregulation of mGluR5 and associated downstream signaling components...
  7. pmc High K+-induced contraction requires depolarization-induced Ca2+ release from internal stores in rat gut smooth muscle
    Timo Kirschstein
    Institute of Physiology, University of Rostock, Gertrudenstrasse 9, 18055 Rostock, Germany
    Acta Pharmacol Sin 30:1123-31. 2009
    ..Depolarization-induced contraction of smooth muscle is thought to be mediated by Ca2+ influx through voltage-gated L-type Ca2+channels. We describe a novel contraction mechanism that is independent of Ca2+ entry...
  8. ncbi request reprint HCN1 channels constrain DHPG-induced LTD at hippocampal Schaffer collateral-CA1 synapses
    Tursonjan Tokay
    Institute of Physiology, University of Rostock, 18055 Rostock, Germany
    Learn Mem 16:769-76. 2009
    ..However, LTD induced by low-frequency stimulation (LFS) remained unaltered in HCN1-deficient mice, suggesting a differential effect of HCN1 channels on synaptic plasticity constraining DHPG-LTD, but not LFS-LTD...
  9. ncbi request reprint GABA(A) receptor inhibition does not affect mGluR-dependent LTD at hippocampal Schaffer collateral-CA1 synapses
    Marco Rohde
    Institute of Physiology, University of Rostock, Gertrudenstrasse 9, 18057 Rostock, Germany
    Neurosci Lett 467:20-5. 2009
    ..Thus, our results show that mGluR-dependent LTD at Schaffer collateral-CA1 synapses is unaffected by GABA(A)R mediated synaptic transmission...
  10. doi request reprint Impaired D-serine-mediated cotransmission mediates cognitive dysfunction in epilepsy
    Katharina Klatte
    Laboratory of Experimental Epileptology, Department of Epileptology and Institute of Molecular Psychiatry, University of Bonn, D 53127 Bonn, Germany
    J Neurosci 33:13066-80. 2013
    ..These results strongly suggest that d-serine deficiency is important in the amnestic symptoms of temporal lobe epilepsy. Our results point to a possible clinical utility of d-serine to alleviate these disease manifestations. ..
  11. ncbi request reprint Impaired synaptic plasticity in a rat model of tuberous sclerosis
    Christian von der Brelie
    Department of Epileptology, University of Bonn Medical Center, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Eur J Neurosci 23:686-92. 2006
    ..An understanding of the underlying molecular pathways may suggest new therapeutic approaches aimed at inhibiting the development of the profound mental retardation in TSC...
  12. doi request reprint Network excitability in a model of chronic temporal lobe epilepsy critically depends on SK channel-mediated AHP currents
    Robert Schulz
    Oscar Langendorff Institute of Physiology, University of Rostock, Gertrudenstrasse 9, 18057 Rostock, Germany
    Neurobiol Dis 45:337-47. 2012
    ....
  13. doi request reprint Positive shifts of the GABAA receptor reversal potential due to altered chloride homeostasis is widespread after status epilepticus
    Gleb Barmashenko
    Oscar Langendorff Institute of Physiology, University of Rostock, Rostock, Germany
    Epilepsia 52:1570-8. 2011
    ..The functional alterations in the epileptiform hippocampus critically depend on GABAergic mechanisms and cation-chloride cotransporters...
  14. ncbi request reprint Upregulation of presynaptic mGluR2, but not mGluR3 in the epileptic medial perforant path
    Judith Rohde
    Oscar Langendorff Institute of Physiology, University of Rostock, Gertrudenstrasse 9, 18057 Rostock, Germany
    Neuropharmacology 62:1867-73. 2012
    ..These results demonstrate that chronic epilepsy not only causes downregulation of mGluRs in the hippocampus, but may also lead to enhanced expression of these receptors - at least in the medial perforant path...
  15. doi request reprint Enhanced NMDA receptor-dependent LTP in the epileptic CA1 area via upregulation of NR2B
    Lorenz Müller
    Oscar Langendorff Institute of Physiology, University of Rostock, Gertrudenstrasse 9, 18057 Rostock, Germany
    Neurobiol Dis 54:183-93. 2013
    ..On the network level, this up-regulation appears to be a compensatory process, since blockade of these receptors leaves the tissue more susceptible to hyperexcitability...
  16. ncbi request reprint Hippocampal synaptic metaplasticity requires inhibitory autophosphorylation of Ca2+/calmodulin-dependent kinase II
    Lian Zhang
    Department of Epileptology, University of Bonn, D 53105 Bonn, Germany
    J Neurosci 25:7697-707. 2005
    ..Thus, modulation of alphaCaMKII activity via autophosphorylation at Thr305/Thr306 is a key mechanism for metaplasticity that may be of importance in the integration of temporally separated episodes of activity...
  17. doi request reprint High-frequency magnetic stimulation induces long-term potentiation in rat hippocampal slices
    Tursonjan Tokay
    Institute of Physiology, University of Rostock, Gertrudenstrasse 9, 18055 Rostock, Germany
    Neurosci Lett 461:150-4. 2009
    ..Further, the lack of changes in paired-pulse ratio and the afferent fiber volleys exclude presynaptic involvement in HFMS-induced LTP. In summary, we have demonstrated that HFMS can induce NMDAR-dependent LTP in the CA1 region in vitro...
  18. pmc Age-dependent contribution of Rho kinase in carbachol-induced contraction of human detrusor smooth muscle in vitro
    Timo Kirschstein
    Oscar Langendorff Institute of Physiology, University of Rostock, Germany
    Acta Pharmacol Sin 35:74-81. 2014
    ..The aim of this study was to determine the relative contributions of MLCK and ROCK to carbachol-induced contraction of human detrusor smooth muscle in vitro...
  19. doi request reprint Increased excitability and compromised long-term potentiation in the neocortex of NPC1(-/-) mice
    Yosef Avchalumov
    Oscar Langendorff Institute of Physiology, University of Rostock, Germany
    Brain Res 1444:20-6. 2012
    ..However, neocortical excitability was significantly enhanced while LTP was abolished. These results suggest that at least in the somatosensory neocortex NPC1 protein is instrumental in synaptic function...
  20. ncbi request reprint L-CCG-I activates group III metabotropic glutamate receptors in the hippocampal CA3 region
    Timo Kirschstein
    Department of Epileptology, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    Neuropharmacology 47:157-62. 2004
    ..For this reason, DCG-IV should be the drug of choice when aiming to discriminate between mossy fiber and A/C input to CA3 pyramidal cells...
  21. doi request reprint Seizure frequency in pilocarpine-treated rats is independent of circadian rhythm
    Rika Bajorat
    Oscar Langendorff Institute of Physiology, University of Rostock, Rostock, Germany
    Epilepsia 52:e118-22. 2011
    ..In 11 chronically epileptic animals monitored up to 300 days after SE in a fixed 12 h light/dark cycle, we found that seizure frequency did not correlate with circadian rhythm...
  22. doi request reprint Effects of oxygen insufflation during pilocarpine-induced status epilepticus on mortality, tissue damage and seizures
    Lorenz Müller
    Oscar Langendorff Institute of Physiology, University of Rostock, Germany
    Epilepsy Res 108:90-7. 2014
    ..This prospective, randomized study was performed to investigate the effects of oxygen (O2) treatment during sustained epileptic activity on mortality, subsequent seizure frequency, and neuronal damage...
  23. doi request reprint Altered physiology and pharmacology in the corticostriatal system in a model of temporal lobe epilepsy
    Yosef Avchalumov
    Oscar Langendorff Institute of Physiology, University of Rostock, Rostock, Germany
    Epilepsia 52:151-7. 2011
    ..Here, our aim was to test whether functional changes occur also in corticostriatal synaptic communication, also because the striatum is instrumental in motor planning and coordination and hence serves important nonlimbic functions...
  24. pmc Localization of HCN1 channels to presynaptic compartments: novel plasticity that may contribute to hippocampal maturation
    Roland A Bender
    Department of Anatomy, University of California, Irvine, Irvine, California 92697 4475, USA
    J Neurosci 27:4697-706. 2007
    ..These findings support a novel developmentally regulated axonal transport of functional ion channels and suggest a role for HCN1 channel-mediated presynaptic I(h) in hippocampal maturation...
  25. ncbi request reprint Functional specialization of presynaptic Cav2.3 Ca2+ channels
    Dirk Dietrich
    Department of Neurosurgery, University Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Neuron 39:483-96. 2003
    ....
  26. ncbi request reprint Acetylsalicylic acid reduces heat responses in rat nociceptive primary sensory neurons--evidence for a new mechanism of action
    Wolfgang Greffrath
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University, Saarstrasse 21, D 55099 Mainz, Germany
    Neurosci Lett 320:61-4. 2002
    ....