Andreas Kirschning

Summary

Affiliation: University of Hannover
Country: Germany

Publications

  1. ncbi request reprint Total synthesis approaches to natural product derivatives based on the combination of chemical synthesis and metabolic engineering
    Andreas Kirschning
    Institute of Organic Chemistry, Leibniz University Hannover, and Center of Biomolecular Drug Research BMWZ, Schneiderberg 1B, 30167 Hannover, Germany
    Org Biomol Chem 5:3245-59. 2007
  2. ncbi request reprint sp3-sp3 Coupling reactions in the synthesis of natural products and biologically active molecules
    Egor Geist
    Institut für Organische Chemie und Zentrum für Biomolekulare Wirkstoffchemie BMWZ, Leibniz Universitat Hannover, Schneiderberg 1B, D 30167 Hannover, Germany
    Nat Prod Rep 31:441-8. 2014
  3. doi request reprint Targeting heat-shock-protein 90 (Hsp90) by natural products: geldanamycin, a show case in cancer therapy
    Jana Franke
    Institut für Organische Chemie und Zentrum für Biomolekulare Wirkstoffchemie BMWZ, Leibniz Universitat Hannover, Schneiderberg 1B, D 30167 Hannover, Germany
    Nat Prod Rep 30:1299-323. 2013
  4. ncbi request reprint Merging chemical synthesis and biosynthesis: a new chapter in the total synthesis of natural products and natural product libraries
    Andreas Kirschning
    Institut für Organische Chemie und Biomolekulares Wirkstoffzentrum BMWZ, Leibniz Universitat Hannover, Schneiderberg 1B, 30167 Hannover Germany
    Angew Chem Int Ed Engl 51:4012-22. 2012
  5. doi request reprint Synthesis and biological evaluation of a polysialic acid-based hydrogel as enzymatically degradable scaffold material for tissue engineering
    Silke Berski
    Institut für Organische Chemie and Zentrum für Biomolekulare Wirkstoffe BMWZ, Gottfried Willhelm Leibniz Universität Hannover, Schneiderberg 1B, 30167 Hannover, Germany
    Biomacromolecules 9:2353-9. 2008
  6. doi request reprint Bioreduction of aryl azides during mutasynthesis of new ansamitocins
    Lena Mancuso
    Institut für Organische Chemie und Biomolekulares Wikstoffzentrum BMWZ der Leibniz Universität Hannover, Schneiderberg 1B, 30167 Hannover, Germany
    Org Lett 15:4442-5. 2013
  7. doi request reprint Mutational biosynthesis of ansamitocin antibiotics: a diversity-oriented approach to exploit biosynthetic flexibility
    Tobias Knobloch
    Zentrum für Biomolekulare Wirkstoffe BMWZ, Leibniz Universität, Hannover Schneiderberg 1B, 30167 Hannover, Germany
    Chembiochem 12:540-7. 2011
  8. doi request reprint Timing of the Delta(10,12)-Delta(11,13) double bond migration during ansamitocin biosynthesis in Actinosynnema pretiosum
    Florian Taft
    Institut für Organische Chemie and Zentrum für Biomolekulare Wirkstoffe BMWZ, Leibniz Universitat Hannover, D 30167 Hannover, Germany
    J Am Chem Soc 131:3812-3. 2009
  9. doi request reprint A practical synthesis of Rho-Kinase inhibitor Y-27632 and fluoro derivatives and their evaluation in human pluripotent stem cells
    Jiri Palecek
    Institut für Organische Chemie and Biomolekulares Wirkstoffzentrum BMWZ, Leibniz Universitat Hannover, Schneiderberg 1B, 30167, Hannover, Germany
    Org Biomol Chem 9:5503-10. 2011
  10. doi request reprint Total synthesis of noricumazole B establishes D-arabinose as glycan unit
    Jenny Barbier
    Institut für Organische Chemie and Biomolekulares Wirkstoffzentrum, Leibniz Universitat Hannover, Germany
    Org Biomol Chem 10:8298-307. 2012

Collaborators

Detail Information

Publications51

  1. ncbi request reprint Total synthesis approaches to natural product derivatives based on the combination of chemical synthesis and metabolic engineering
    Andreas Kirschning
    Institute of Organic Chemistry, Leibniz University Hannover, and Center of Biomolecular Drug Research BMWZ, Schneiderberg 1B, 30167 Hannover, Germany
    Org Biomol Chem 5:3245-59. 2007
    ..Recent developments in metabolic engineering promise to further broaden the scope of outsourcing chemically demanding steps to biological systems...
  2. ncbi request reprint sp3-sp3 Coupling reactions in the synthesis of natural products and biologically active molecules
    Egor Geist
    Institut für Organische Chemie und Zentrum für Biomolekulare Wirkstoffchemie BMWZ, Leibniz Universitat Hannover, Schneiderberg 1B, D 30167 Hannover, Germany
    Nat Prod Rep 31:441-8. 2014
    ..This Highlight covers the current status of relatively unexplored sp(3)-sp(3) cross-coupling reactions with particular focus on natural product and related syntheses...
  3. doi request reprint Targeting heat-shock-protein 90 (Hsp90) by natural products: geldanamycin, a show case in cancer therapy
    Jana Franke
    Institut für Organische Chemie und Zentrum für Biomolekulare Wirkstoffchemie BMWZ, Leibniz Universitat Hannover, Schneiderberg 1B, D 30167 Hannover, Germany
    Nat Prod Rep 30:1299-323. 2013
    ....
  4. ncbi request reprint Merging chemical synthesis and biosynthesis: a new chapter in the total synthesis of natural products and natural product libraries
    Andreas Kirschning
    Institut für Organische Chemie und Biomolekulares Wirkstoffzentrum BMWZ, Leibniz Universitat Hannover, Schneiderberg 1B, 30167 Hannover Germany
    Angew Chem Int Ed Engl 51:4012-22. 2012
    ..This Minireview describes "hybrid" strategies of organic synthesis and biosynthesis that result in facile access to complex natural products and libraries based on them...
  5. doi request reprint Synthesis and biological evaluation of a polysialic acid-based hydrogel as enzymatically degradable scaffold material for tissue engineering
    Silke Berski
    Institut für Organische Chemie and Zentrum für Biomolekulare Wirkstoffe BMWZ, Gottfried Willhelm Leibniz Universität Hannover, Schneiderberg 1B, 30167 Hannover, Germany
    Biomacromolecules 9:2353-9. 2008
    ..Here, additional coating with collagen I, poly-L-lysine or matrigel is mandatory to improve the properties of the material...
  6. doi request reprint Bioreduction of aryl azides during mutasynthesis of new ansamitocins
    Lena Mancuso
    Institut für Organische Chemie und Biomolekulares Wikstoffzentrum BMWZ der Leibniz Universität Hannover, Schneiderberg 1B, 30167 Hannover, Germany
    Org Lett 15:4442-5. 2013
    ..This mutasynthetic experiment yielded the fully processed azido derivative of geldanamycin. ..
  7. doi request reprint Mutational biosynthesis of ansamitocin antibiotics: a diversity-oriented approach to exploit biosynthetic flexibility
    Tobias Knobloch
    Zentrum für Biomolekulare Wirkstoffe BMWZ, Leibniz Universität, Hannover Schneiderberg 1B, 30167 Hannover, Germany
    Chembiochem 12:540-7. 2011
    ....
  8. doi request reprint Timing of the Delta(10,12)-Delta(11,13) double bond migration during ansamitocin biosynthesis in Actinosynnema pretiosum
    Florian Taft
    Institut für Organische Chemie and Zentrum für Biomolekulare Wirkstoffe BMWZ, Leibniz Universitat Hannover, D 30167 Hannover, Germany
    J Am Chem Soc 131:3812-3. 2009
    ....
  9. doi request reprint A practical synthesis of Rho-Kinase inhibitor Y-27632 and fluoro derivatives and their evaluation in human pluripotent stem cells
    Jiri Palecek
    Institut für Organische Chemie and Biomolekulares Wirkstoffzentrum BMWZ, Leibniz Universitat Hannover, Schneiderberg 1B, 30167, Hannover, Germany
    Org Biomol Chem 9:5503-10. 2011
    ..Compared to Y-27632 the new fluoro derivatives showed reduced or no effect on hPSC vitality and expansion after dissociation in human pluripotent stem cells...
  10. doi request reprint Total synthesis of noricumazole B establishes D-arabinose as glycan unit
    Jenny Barbier
    Institut für Organische Chemie and Biomolekulares Wirkstoffzentrum, Leibniz Universitat Hannover, Germany
    Org Biomol Chem 10:8298-307. 2012
    ..The total synthesis of noricumazole B, a secondary metabolite from myxobacteria, was achieved. It established the glycan moiety to be D-α-arabinoside...
  11. doi request reprint Total synthesis of a noricumazole A library and evaluation of HCV inhibition
    Jenny Barbier
    Institut für Organische Chemie und Zentrum für Biomolekulare Wirkstoffe BMWZ, Leibniz Universitat Hannover, Schneiderberg 1B, 30167 Hannover, Germany
    Chemistry 18:9083-90. 2012
    ..In contrast, the thiazole analogue of noricumazole A is a strong HCV inhibitor with only moderate cytotoxic property. It may become a lead structure with a good therapeutic index (CC(50)/IC(50)) of greater than 10...
  12. pmc Broad substrate specificity of the amide synthase in S. hygroscopicus--new 20-membered macrolactones derived from geldanamycin
    Simone Eichner
    Institute of Organic Chemistry and Center of Biomolecular Research BMWZ, Schneiderberg 1B, Leibniz University Hannover, D 30167 Hannover, Germany
    J Am Chem Soc 134:1673-9. 2012
    ..Good to moderate antiproliferative activities were encountered for three of the five new geldanamycin derivatives, which matched well with a competition assay for Hsp90α...
  13. doi request reprint Glycosidations of 2-deoxy glycosyl dithiophosphates using a tagged iodine(III)-promoter for simple purification
    Eike Kunst
    Institut für Organische Chemie and Zentrum für Biomolekulare Wirkstoffe BMWZ, Leibniz Universitat Hannover, Schneiderberg 1B, 30167 Hannover, Germany
    Org Biomol Chem 6:893-8. 2008
    ..The preparation of the 4-i-butylsulfonate derivative of the Zefirov reagent (5) and its use in a novel purification strategy for iodine(III)-promoted glycosidations of 2-deoxy diethyldithiophosphate glycosides is described...
  14. doi request reprint Inductive heating with magnetic materials inside flow reactors
    Sascha Ceylan
    Institut für Organische Chemie and Zentrum für Biomolekulare Wirkstoffe BMWZ, Leibniz Universitat Hannover, Schneiderberg 1B, 30167 Hannover, Germany
    Chemistry 17:1884-93. 2011
    ..Silica-coated iron oxide nanoparticles are stable under many chemical conditions and the silica shell could be utilized for further functionalization with Pd nanoparticles, rendering catalytically active heatable iron oxide particles...
  15. doi request reprint Combined muta- and semisynthesis: a powerful synthetic hybrid approach to access target specific antitumor agents based on ansamitocin P3
    Florian Taft
    Institut für Organische Chemie und Biomolekulares Wirkstoffzentrum BMWZ, Leibniz Universitat Hannover, Schneiderberg 1B, 30167 Hannover, Germany
    Chemistry 18:880-6. 2012
    ..The synthetic strategy pursued is based on the combination of mutasynthesis and semisynthesis and proved to be powerful for accessing new ansamitocin derivatives that are difficult to prepare by total synthesis...
  16. doi request reprint Synthesis of new polysialic acid derivatives
    Yi Su
    Institut fur Organische Chemie, Gottfried Wilhelm Leibniz Universität Hannover, Schneiderberg 1B, 30167 Hannover, Germany
    Macromol Biosci 10:1028-33. 2010
    ..In contrast a variety of N-derivatives of polysialic acid can be prepared starting from deacetylated polysialic acid. The N-derivatives prepared in this communication can be used for the Cu-catalyzed as well as Cu-free "click" chemistry...
  17. doi request reprint Highly active ansamitocin derivatives: mutasynthesis using an AHBA-blocked mutant
    Florian Taft
    Zentrum für Biomolekulare Wirkstoffe BMWZ, Leibniz Universitat Hannover, Schneiderberg 1B, 30167 Hannover, Germany
    Chembiochem 9:1057-60. 2008
  18. ncbi request reprint The interplay between mutasynthesis and semisynthesis: generation and evaluation of an ansamitocin library
    Simone Eichner
    Institut für Organische Chemie und Biomolekulares Wirkstoffzentrum BMWZ, Leibniz Universitat Hannover, Schneiderberg 1B, 30167 Hannover, Germany
    Angew Chem Int Ed Engl 51:752-7. 2012
  19. doi request reprint Ten key issues in modern flow chemistry
    Jens Wegner
    Institute of Organic Chemistry and Center of Biomolecular Drug Research BMWZ, Leibniz Universitat Hannover, Schneiderberg 1B, 30167 Hannover, Germany
    Chem Commun (Camb) 47:4583-92. 2011
    ..Ten essentials of synthesis in the flow mode, a new enabling technology in organic chemistry, are highlighted as flashlighted providing an insight into current and future issues and developments in this field...
  20. doi request reprint Stereochemical determination of thuggacins A-C, highly active antibiotics from the myxobacterium Sorangium cellulosum
    Martin Bock
    Institut für Organische Chemie und Biomolekulares Wirkstoffzentrum, Leibniz Universitat Hannover, Schneiderberg 1B, 30167 Hannover, Germany
    Angew Chem Int Ed Engl 47:2308-11. 2008
  21. ncbi request reprint Microarray-based screening of heat shock protein inhibitors
    Emilia Schax
    Leibniz Universitat Hannover, Institut für Technische Chemie and Biomolekulares Wirkstoffzentrum BMWZ, Callinstr 5, D 30167 Hannover, Germany
    J Biotechnol 180:1-9. 2014
    ..5 nM to 4 μM and Z(*)-factors between 0.60 and 0.96. Our results demonstrate the potential of a target-oriented multiplexed protein microarray to identify novel inhibitors for different members of the HSP90 family...
  22. doi request reprint Heating under High-Frequency Inductive Conditions: Application to the Continuous Synthesis of the Neurolepticum Olanzapine (Zyprexa)
    Jan Hartwig
    Institut fur Organische Chemie, Leibniz Universitat Hannover, Schneiderberg 1B, 30167 Hannover Germany
    Angew Chem Int Ed Engl 52:9813-7. 2013
    ..This is demonstrated in the multistep flow synthesis of the neurolepticum olanzapine (Zyprexa) that included three reactions with inductive heating and two purification steps conducted as continuous processes. ..
  23. ncbi request reprint Chemoenzymatic approaches toward dechloroansamitocin P-3
    Axel Meyer
    Institut fur Organische Chemie, Leibniz Universitat Hannover, Schneiderberg 1B, 30167 Hannover, Germany
    Org Lett 9:1489-92. 2007
    ....
  24. ncbi request reprint Enzyme-purification and catalytic transformations in a microstructured PASSflow reactor using a new tyrosine-based Ni-NTA linker system attached to a polyvinylpyrrolidinone-based matrix
    Gerald Dräger
    Institut für Organische Chemie and Zentrum für Biomolekulare Wirkstoffchemie BMWZ, Leibniz Universitat Hannover, Schneiderberg 1B, Hannover, Germany
    Org Biomol Chem 5:3657-64. 2007
    ..These could be used as stable and highly active biocatalysts for the synthesis of (R)-benzoin (6), (R)-2-hydroxy-1-phenylpropan-1-one (7) and 6-O-acetyl-D-glucal (17) in a flow-through mode...
  25. pmc Unprecedented deoxygenation at C-7 of the ansamitocin core during mutasynthetic biotransformations
    Tobias Knobloch
    Institute of Organic Chemistry and Center of Biomolecular Drug Research BMWZ, Leibniz University Hannover, Schneiderberg 1B, 30167 Hannover, Germany
    Beilstein J Org Chem 8:861-9. 2012
    ..In bioactivity tests, only ansamitocin derivatives bearing an ester side chain at C-3 showed strong antiproliferative activity...
  26. pmc Towards a biocompatible artificial lung: Covalent functionalization of poly(4-methylpent-1-ene) (TPX) with cRGD pentapeptide
    Lena Möller
    Institut für Organische Chemie und Biomolekulares Wirkstoffzentrum BMWZ der Leibniz Universität Hannover, Schneiderberg 1B, 30167 Hannover, Germany
    Beilstein J Org Chem 9:270-7. 2013
    ..The resulting modified membrane preserves the required excellent gas-flow properties while being densely seeded with lung endothelial cells...
  27. doi request reprint Substrate-controlled stereoselectivity in the Yamamoto aldol reaction
    Nadin Schläger
    Institute of Organic Chemistry and Center of Biomolecular Drug Research BMWZ, Schneiderberg 1B, 30167 Hannover
    Org Biomol Chem 10:7721-9. 2012
    ..Large substituents favour formation of 1,3-syn diols while slim alkynyl groups preferentially lead to 1,3-anti products...
  28. ncbi request reprint 2-Pyridinealdoxime, a new ligand for a Pd-precatalyst: application in solid-phase-assisted Suzuki-Miyaura reaction
    Wladimir Solodenko
    , , Schneiderberg 1B, D 30167, Hannover, Germany
    Mol Divers 9:333-9. 2005
    ..Several concepts for the immobilization of this catalytic system are presented and compared in order to develop an efficient catalytic tool for high-throughput synthesis...
  29. doi request reprint Recent advances in the total synthesis of pharmaceutically relevant diterpenes
    Torsten Busch
    Institut für Organische Chemie und Zentrum für Biomolekulare Wirkstoffchemie BMWZ, Leibniz Universitat Hannover, Schneiderberg 1B, Hannover, D 30167, Germany
    Nat Prod Rep 25:318-41. 2008
    ..Additionally, all four diterpenoids are of major relevance because of their biological (target) or pharmaceutical properties...
  30. pmc Multistep flow synthesis of vinyl azides and their use in the copper-catalyzed Huisgen-type cycloaddition under inductive-heating conditions
    Lukas Kupracz
    Institute of Organic Chemistry, Leibniz University Hannover, Schneiderberg 1B, 30167 Hannover, Germany
    Beilstein J Org Chem 7:1441-8. 2011
    ..The required heat is generated by electromagnetic induction based on copper. Copper serves both as heatable as well as catalytically active packed-bed material inside the flow reactor...
  31. doi request reprint Bioorthogonal metal-free click-ligation of cRGD-pentapeptide to alginate
    Andreas Krause
    Institut für Organische Chemie and Biomolekulares Wirkstoffzentrum BMWZ, Leibniz Universitat Hannover, Schneiderberg 1B, 30167 Hannover, Germany
    Org Biomol Chem 10:5547-53. 2012
    ..This report unfolds the first aqueous metal-free "click" conjugation of a cyclic RGD-pentapeptide with the biomacromolecule alginate, creating a "smart" bioactive polymer with potential applications in biomedicine...
  32. ncbi request reprint Hetero-diels-alder reactions of cyclic ketone derived enamide. A new and efficient concept for the asymmetric robinson annulation
    Florian Gallier
    UCO2M UMR 6011 and FR 2575 CNRS, Universite du Maine, 72085, Le Mans, France, and Institut fur Organische Chemie der Leibniz Universitat Hannover, Schneiderberg 1B, 30167 Hannover, Germany
    Org Lett 11:3060-3. 2009
    ..From the resulting bicyclic heteroadducts, a novel and efficient asymmetric modification for the Robinson annulation of cyclic monoketones is described...
  33. doi request reprint Polymer-assisted dithane hydrolysis with minimum workup
    Silke Luiken
    Institut für Organische Chemie and Center of Biomolecular Drug Research BMWZ, Leibniz Universitat Hannover, Schneiderberg 1B, 30167 Hannover, Germany
    J Org Chem 73:2018-20. 2008
    ..The hydrolysis and the purification proceed under milder conditions than common homogeneously employed reagents so that very reactive carbonyl compounds can be prepared...
  34. doi request reprint A total synthesis of millingtonine A
    Jens Wegner
    Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, UK
    Org Lett 14:696-9. 2012
    ..Millingtonine A possesses a unique racemic tricyclic core structure not known from any other natural or synthetic source until now. The synthesis features a key bond-forming radical Ueno-Stork cyclization to form the heterocyclic core...
  35. ncbi request reprint Synthesis of a cytotoxic ansamycin hybrid
    Gerrit Jürjens
    Institute of Organic Chemistry and Center of Biomolecuclar Drug Research BMWZ, Leibniz Universitat Hannover, Schneiderberg 1B, 30167 Hannover, Germany
    Org Lett 16:3000-3. 2014
    ..hygroscopicus, the geldanamycin producer. The ansamycin hybrid forms atropisomers that differ in their antiproliferative activity toward cancer cells. ..
  36. ncbi request reprint Continuous flow chemistry: a discovery tool for new chemical reactivity patterns
    Jan Hartwig
    Institut fur Organische Chemie, Leibniz Universitat Hannover, Schneiderberg 1B, 30167 Hannover, Germany
    Org Biomol Chem 12:3611-5. 2014
    ..This new reactivity can be explained by suppressing back mixing and precise control of temperature in a flow reactor set up. ..
  37. ncbi request reprint Total synthesis of carolacton, a highly potent biofilm inhibitor
    Thomas Schmidt
    Institut für Organische Chemie und Zntrum für Biomolekulare Wirkstoffe BMWZ, Leibniz Universitat Hannover, Schneiderberg 1B, 30167 Hannover, Germany
    Angew Chem Int Ed Engl 51:1063-6. 2012
  38. ncbi request reprint Chemoenzymatic synthesis of CMP-N-acetyl-7-fluoro-7-deoxy-neuraminic acid
    Sina Hartlieb
    Institut für Organische Chemie und Zentrum für Biomolekulare Wirkstoffchemie BMWZ, Gottfried Wilhelm Leibniz Universität Hannover, Schneiderberg 1B, 30167 Hannover, Germany
    Carbohydr Res 343:2075-82. 2008
    ..Finally, conditions were optimized to perform a one-pot reaction starting from fluorinated mannosamine, which yielded the 7-fluoro-7-deoxy-CMP-sialic acid by incubation with three enzymes...
  39. ncbi request reprint Synthetic and structural studies on macrocyclic amino cyclitols--conformational chameleons
    Benjamin Oelze
    Institut fur Organische Chemie, Leibniz Universitat Hannover, Schneiderberg 1B, D 30167, Hannover, Germany
    Org Biomol Chem 6:2412-25. 2008
    ....
  40. ncbi request reprint Tagged hypervalent iodine reagents: a new purification concept based on ion exchange through SN2 substitution
    Eike Kunst
    Institut für Organische Chemie der Leibniz Universität Hannover, Schneiderberg 1B, 30167 Hannover, Germany
    Org Lett 9:5199-202. 2007
    ..The concept is successfully proven for Ru-catalyzed oxidations of alcohols, the activation and glycosidation of thioglycosides, and the SuArez reaction of pyranoses...
  41. doi request reprint Total synthesis of the antibiotic elansolid B1
    Arne Weber
    Institut für Organische Chemie und Biomolekulares Wirkstoffzentrum BMWZ, Leibniz Universitat Hannover, Schneiderberg 1B, 30167 Hannover, Germany
    Org Lett 16:568-71. 2014
    ..Other key features are a double Sonogashira cross-coupling and a substrate-controlled Yamamoto aldol reaction. ..
  42. ncbi request reprint Collagen biomaterial doped with colominic acid for cell culture applications with regard to peripheral nerve repair
    Stephanie Bruns
    Universitat Hannover, Institut fur Technische Chemie, Callinstr 3, D 30167 Hannover, Germany
    J Biotechnol 131:335-45. 2007
    ..The results indicate that CA integration in established biomaterial constructs enhances cell proliferation and offers promising features as conduits additive in regarding peripheral nerve regeneration...
  43. ncbi request reprint Isolation and Total Synthesis of Icumazoles and Noricumazoles-Antifungal Antibiotics and Cation-Channel Blockers from Sorangium cellulosum
    Jenny Barbier
    Institut für Organische Chemie und Zentrum für Biomolekulare Wirkstoffe BMWZ, Leibniz Universitat Hannover, Schneiderberg 1B, 30167 Hannover Germany
    Angew Chem Int Ed Engl 51:1256-60. 2012
    ..Their structures have been fully assigned by a joint strategy that relied on spectroscopy, derivatization, fragmentation, and finally the first total synthesis of noricumazole A...
  44. ncbi request reprint Polymer-assisted Horner-Emmons olefination using PASSflow reactors: pure products without purification
    Wladimir Solodenko
    Institut für Organische Chemie der Universität Hannover, Schneiderberg 1B, Germany
    Bioorg Med Chem Lett 12:1833-5. 2002
    ..A PASSflow protocol for the Horner-Emmons olefination of aldehydes using polymer-bound hydroxide ions in flowthrough reactors is presented which allows preparation of alkenes in very high yield with minimal purification...
  45. ncbi request reprint Total synthesis and elucidation of the absolute configuration of the diterpene tonantzitlolone
    Christian Jasper
    Institut für Organische Chemie der Universität Hannover, Schneiderberg 1B, D 30167 Hannover, Germany
    Org Lett 7:479-82. 2005
    ..The absolute configuration of tonantzitlolone is established...
  46. ncbi request reprint Determination of the cryptic stereochemistry of the first PKS chain-extension step in ansamitocin biosynthesis by Actinosynnema pretiosum
    Takaaki Kubota
    Department of Chemistry, University of Washington, Seattle, WA 98195 1700, USA
    Chembiochem 7:1221-5. 2006
    ..A presumed next chain-extension intermediate-the triketide with an unrearranged double bond-was also synthesized as its SNAC ester, but did not complement the AHBA(-) mutant...
  47. ncbi request reprint Sustainable concepts in olefin metathesis
    Hervé Clavier
    Institute of Chemical Research of Catalonia ICIQ, Av Paisos Catalans 16, 43007 Tarragona, Spain
    Angew Chem Int Ed Engl 46:6786-801. 2007
    ..This Review summarizes the numerous studies focused on developing cleaner ruthenium-catalyzed metathesis processes...
  48. ncbi request reprint Total synthesis of cyclic diterpene tonantzitlolone based on a highly stereoselective substrate-controlled aldol reaction and ring-closing metathesis
    Christian Jasper
    Universitat Basel, Departement Chemie, Spitalstrasse 51, 4065 Basel, Switzerland
    Chemistry 12:8719-34. 2006
    ..A detailed investigation of these two steps and the final transformations towards the completion of the synthesis is disclosed...
  49. ncbi request reprint Polymer/carrier composites as materials and reactors for organic synthesis
    Ulrich Kunz
    Institut für Chemische Verfahrenstechnik, Technische Universitat Clausthal, Leibnizstrasse 17, D 38678 Clausthal Zellerfeld, Germany
    J Chromatogr A 1006:241-9. 2003
    ..Additionally, the use of these monolithic columns as catalytic microreactors and their performance in selected reactions are described...
  50. ncbi request reprint Preparation and X-ray structures of 3-[Bis(trifluoroacetoxy)iodo]benzoic acid and 3-[hydroxy(tosyloxy)iodo]benzoic acid: new recyclable hypervalent iodine reagents
    Mekhman S Yusubov
    The Siberian State Medical University and The Tomsk Polytechnic University, 2 Moskovsky Trakt, 634050 Tomsk, Russia
    J Org Chem 73:295-7. 2008
    ..The reduced form of these reagents, 3-iodobenzoic acid, can be easily recovered from the reaction mixtures using ion-exchange resin or basic aqueous workup followed by acidification with HCl...
  51. ncbi request reprint Synthesis of the N-acetylcysteamine thioester of seco-proansamitocin
    Thomas Frenzel
    Institut für Organische Chemie der Universität Hannover, Germany
    Org Lett 8:135-8. 2006
    ..The key step is a Heck reaction between two terminal alkenes for merging the two major fragments...