James C Kirkpatrick

Summary

Affiliation: University of Mainz
Country: Germany

Publications

  1. pmc Predictive toxicology of cobalt ferrite nanoparticles: comparative in-vitro study of different cellular models using methods of knowledge discovery from data
    Limor Horev-Azaria
    Department of Physiology and Pharmacology, Faculty of Medicine and the Marian Gertner Institute for Medical Nanosystems, Tel Aviv University, Tel Aviv 69978, Israel
    Part Fibre Toxicol 10:32. 2013
  2. pmc Cyclooxygenases and prostaglandin E2 receptors in growth plate chondrocytes in vitro and in situ--prostaglandin E2 dependent proliferation of growth plate chondrocytes
    Christoph Brochhausen
    Institute of Pathology, Johannes Gutenberg University, Mainz, Germany
    Arthritis Res Ther 8:R78. 2006
  3. ncbi request reprint The non-neuronal cholinergic system in the endothelium: evidence and possible pathobiological significance
    C J Kirkpatrick
    Institute of Pathology, Johannes Gutenberg University, Mainz, Germany
    Jpn J Pharmacol 85:24-8. 2001
  4. ncbi request reprint Expression and function of the non-neuronal cholinergic system in endothelial cells
    C James Kirkpatrick
    Institute of Pathology, Johannes Gutenberg University, Klinikum, Langenbeckstrasse 1, D 55101 Mainz, Germany
    Life Sci 72:2111-6. 2003
  5. pmc Biomaterial-induced sarcoma: A novel model to study preneoplastic change
    C J Kirkpatrick
    Institute of Pathology, Johannes Gutenberg University, Mainz, Germany
    Am J Pathol 156:1455-67. 2000
  6. ncbi request reprint [Pathomechanisms of impaired wound healing by metallic corrosion products]
    C J Kirkpatrick
    Institut fur Pathologie, Klinikum, Johannes Gutenberg Universitat, Langenbeckstrasse 1, 55101 Mainz
    Mund Kiefer Gesichtschir 6:183-90. 2002
  7. ncbi request reprint Tissue response and biomaterial integration: the efficacy of in vitro methods
    C J Kirkpatrick
    Institute of Pathology, Johannes Gutenberg University, Langenbeckstr 1, D 55101 Mainz, Germany
    Biomol Eng 19:211-7. 2002
  8. doi request reprint Co-culture systems for vascularization--learning from nature
    C James Kirkpatrick
    REPAIR Lab, Institute of Pathology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany
    Adv Drug Deliv Rev 63:291-9. 2011
  9. ncbi request reprint Vascularization and gene regulation of human endothelial cells growing on porous polyethersulfone (PES) hollow fiber membranes
    Ronald E Unger
    Institute of Pathology, Johannes Gutenberg University, Langenbeckstr 1, 55101 Mainz, Germany
    Biomaterials 26:3461-9. 2005
  10. ncbi request reprint In vitro expression of the endothelial phenotype: comparative study of primary isolated cells and cell lines, including the novel cell line HPMEC-ST1.6R
    Ronald E Unger
    Institute of Pathology, Johannes Gutenberg University, Langenbeckstrasse 1, D 55101 Mainz, Germany
    Microvasc Res 64:384-97. 2002

Collaborators

Detail Information

Publications108 found, 100 shown here

  1. pmc Predictive toxicology of cobalt ferrite nanoparticles: comparative in-vitro study of different cellular models using methods of knowledge discovery from data
    Limor Horev-Azaria
    Department of Physiology and Pharmacology, Faculty of Medicine and the Marian Gertner Institute for Medical Nanosystems, Tel Aviv University, Tel Aviv 69978, Israel
    Part Fibre Toxicol 10:32. 2013
    ..Cobalt-ferrite nanoparticles (Co-Fe NPs) are attractive for nanotechnology-based therapies. Thus, exploring their effect on viability of seven different cell lines representing different organs of the human body is highly important...
  2. pmc Cyclooxygenases and prostaglandin E2 receptors in growth plate chondrocytes in vitro and in situ--prostaglandin E2 dependent proliferation of growth plate chondrocytes
    Christoph Brochhausen
    Institute of Pathology, Johannes Gutenberg University, Mainz, Germany
    Arthritis Res Ther 8:R78. 2006
    ..In cultured chrondrocytes, however, only weak expression of EP3 and EP4 receptor was detected. We suggest that in growth plate chondrocytes, COX-2 is responsible for PGE2 release, which stimulates cell proliferation via the EP1 receptor...
  3. ncbi request reprint The non-neuronal cholinergic system in the endothelium: evidence and possible pathobiological significance
    C J Kirkpatrick
    Institute of Pathology, Johannes Gutenberg University, Mainz, Germany
    Jpn J Pharmacol 85:24-8. 2001
    ..The biological functions of ACh synthesized by endothelial cells are the focus of ongoing research activity...
  4. ncbi request reprint Expression and function of the non-neuronal cholinergic system in endothelial cells
    C James Kirkpatrick
    Institute of Pathology, Johannes Gutenberg University, Klinikum, Langenbeckstrasse 1, D 55101 Mainz, Germany
    Life Sci 72:2111-6. 2003
    ..Further experiments are addressed to elucidate the biological role of acetylcholine in the endothelium and possible differences between the different subtypes of endothelial cells...
  5. pmc Biomaterial-induced sarcoma: A novel model to study preneoplastic change
    C J Kirkpatrick
    Institute of Pathology, Johannes Gutenberg University, Mainz, Germany
    Am J Pathol 156:1455-67. 2000
    ..This model provides the molecular biologist with defined stages in the development of mesenchymal malignancy, with which the multistage tumorigenesis hypothesis can be tested, analogous to the well-known adenoma-carcinoma sequence...
  6. ncbi request reprint [Pathomechanisms of impaired wound healing by metallic corrosion products]
    C J Kirkpatrick
    Institut fur Pathologie, Klinikum, Johannes Gutenberg Universitat, Langenbeckstrasse 1, 55101 Mainz
    Mund Kiefer Gesichtschir 6:183-90. 2002
    ..In this paper we present relevant aspects of the related fields of inflammation and repair processes and focus on the pathomechanisms of this impaired healing response...
  7. ncbi request reprint Tissue response and biomaterial integration: the efficacy of in vitro methods
    C J Kirkpatrick
    Institute of Pathology, Johannes Gutenberg University, Langenbeckstr 1, D 55101 Mainz, Germany
    Biomol Eng 19:211-7. 2002
    ....
  8. doi request reprint Co-culture systems for vascularization--learning from nature
    C James Kirkpatrick
    REPAIR Lab, Institute of Pathology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany
    Adv Drug Deliv Rev 63:291-9. 2011
    ....
  9. ncbi request reprint Vascularization and gene regulation of human endothelial cells growing on porous polyethersulfone (PES) hollow fiber membranes
    Ronald E Unger
    Institute of Pathology, Johannes Gutenberg University, Langenbeckstr 1, 55101 Mainz, Germany
    Biomaterials 26:3461-9. 2005
    ....
  10. ncbi request reprint In vitro expression of the endothelial phenotype: comparative study of primary isolated cells and cell lines, including the novel cell line HPMEC-ST1.6R
    Ronald E Unger
    Institute of Pathology, Johannes Gutenberg University, Langenbeckstrasse 1, D 55101 Mainz, Germany
    Microvasc Res 64:384-97. 2002
    ..Thus, HPMEC-ST1.6R will be a valuable in vitro model system in which to study pathomechanisms and angiogenesis of the mature microvascular endothelium in vitro...
  11. ncbi request reprint The expression of cathepsins in osteoclast-like giant cells of an anaplastic thyroid carcinoma with tracheal perforation
    A Gaumann
    Institut fur Pathologie, Ohrenheilkunde, Universitatsklinik Mainz, Germany
    Pathol Res Pract 197:257-62. 2001
    ..Expression of cathepsins B and K in the MGC of the ACT might contribute to the invasive behavior of this tumor, thus promoting metastatic ability and destruction of the cartilagenous trachea...
  12. ncbi request reprint Expression of cysteine proteinases cathepsins B and K and of cysteine proteinase inhibitor cystatin C in giant cell tumor of tendon sheath
    T Hansen
    Institute of Pathology, Johannes Gutenberg-University, Mainz, Germany
    Mod Pathol 14:318-24. 2001
    ..Because previous studies showed that osteoclasts express high levels of CD68, cathepsin K, and cystatin C but not of cathepsin B, our study contributes to the view that GC of GCTTS and osteoclasts are closely associated...
  13. ncbi request reprint Differential adhesion of polymorphous neutrophilic granulocytes to macro- and microvascular endothelial cells under flow conditions
    M Otto
    Institute of Pathology, Johannes Gutenberg University of Mainz, Mainz, Germany
    Pathobiology 69:159-71. 2001
    ..The purpose of the present study was to use a dynamic cell culture system to compare the reactions of HUVEC and human pulmonary microvascular EC (HPMEC) to pro-inflammatory stimulation...
  14. ncbi request reprint Expression of apoptosis-related proteins, p53, and DNA fragmentation in sarcomas of the pulmonary artery
    A Gaumann
    Institute of Pathology, University of Mainz, Mainz, Germany
    Cancer 92:1237-44. 2001
    ..In particular, members of the Bcl-2 family as well as the Fas system are known to be involved in the regulation of apoptosis in different tumor entities...
  15. ncbi request reprint Generation of human pulmonary microvascular endothelial cell lines
    V Krump-Konvalinkova
    Institute of Pathology, Johannes-Gutenberg University, Mainz, Germany
    Lab Invest 81:1717-27. 2001
    ..The microvascular endothelial cell line, HPMEC-ST1.6R, will be a valuable tool for the study of microvascular endothelial physiology and pathology including gene expression, angiogenesis, and tumorigenesis...
  16. ncbi request reprint Comparative study assessing effects of sonic hedgehog and VEGF in a human co-culture model for bone vascularisation strategies
    E Dohle
    REPAIR Lab, Institute of Pathology, University Medical Center of the Johannes Gutenberg University, Langenbeckstrasse 1, D 55101 Mainz, Germany
    Eur Cell Mater 21:144-56. 2011
    ..Experiments using cyclopamine, a Shh pathway inhibitor, blocked the effects of Shh...
  17. ncbi request reprint Release of non-neuronal acetylcholine from the human placenta: difference to neuronal acetylcholine
    I Wessler
    Department of Pharmacology, University of Mainz, Obere Zahlbacher Strasse 67, 55101 Mainz, Germany
    Naunyn Schmiedebergs Arch Pharmacol 364:205-12. 2001
    ..Thus, cholinesterase inhibitors increase assayed acetylcholine by two mechanisms, protection of hydrolysis and stimulation of facilitatory nicotine receptors...
  18. doi request reprint An injectable bone substitute composed of beta-tricalcium phosphate granules, methylcellulose and hyaluronic acid inhibits connective tissue influx into its implantation bed in vivo
    S Ghanaati
    Institute of Pathology, University Medical Center of the Johannes Gutenberg University, Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
    Acta Biomater 7:4018-28. 2011
    ..In addition, this combination increased the vascularization of the implantation bed, which is essential for successful tissue regeneration...
  19. ncbi request reprint Endothelial VEGFR-3 expression in colorectal carcinomas is associated with hematogenous metastasis
    C Jayasinghe
    Institute of Pathology, Johannes Gutenberg University, 55101 Mainz, Germany
    Oncol Rep 22:1093-100. 2009
    ..In addition, due to their patency VEGFR-3-positive peritumoral, but not intratumoral lymphatics could be the vascular substrate functionally mediating lymphogenous metastasis...
  20. doi request reprint Influence of polymer content in Ca-deficient hydroxyapatite-polycaprolactone nanocomposites on the formation of microvessel-like structures
    S Fuchs
    Institute of Pathology, Langenbeckstrasse 1, Universitätsmedizin der Johannes Gutenberg Universität, Mainz, Germany
    Acta Biomater 6:3169-77. 2010
    ..In contrast to this, variation of PCL content had no effect on the osteogenic differentiation in the co-culture...
  21. ncbi request reprint Endothelialization of a non-woven silk fibroin net for use in tissue engineering: growth and gene regulation of human endothelial cells
    R E Unger
    Institute of Pathology, Johannes Gutenberg University, Langenbeckstr 1, Mainz 55101, Germany
    Biomaterials 25:5137-46. 2004
    ....
  22. ncbi request reprint Expression of matrix-degrading cysteine proteinase cathepsin K in cholesteatoma
    T Hansen
    Institute of Pathology, Johannes Gutenberg University, Mainz, Germany
    Mod Pathol 14:1226-31. 2001
    ..Strong expression of this collagenolytic enzyme in osteoclasts suggests that these cells are mainly involved in cathepsin K-mediated bone destruction...
  23. ncbi request reprint Heterogeneous expression of cell adhesion molecules by endothelial cells in ARDS
    Annette M Müller
    Institute of Pathology, University Clinic Bergmannsheil, Ruhr University Bochum, Burkle de la Camp Platz 1, 44789 Bochum, Germany
    J Pathol 198:270-5. 2002
    ..There is also markedly heterogeneous expression of E-selectin and VCAM, indicating toporegional differences in the function of pulmonary ECs...
  24. doi request reprint The effect of human osteoblasts on proliferation and neo-vessel formation of human umbilical vein endothelial cells in a long-term 3D co-culture on polyurethane scaffolds
    Alexander Hofmann
    Department of Trauma Surgery, Johannes Gutenberg University School of Medicine, Langenbeckstrasse 1, D 55101 Mainz, Germany
    Biomaterials 29:4217-26. 2008
    ..The three-dimensional, FCS-free co-culture system could provide a new basis for the development of complex tissue engineered constructs with a high regeneration and vascularization capacity...
  25. doi request reprint Biocompatibility studies of endothelial cells on a novel calcium phosphate/SiO2-xerogel composite for bone tissue engineering
    Benjamin W Thimm
    Institute of Pathology, Johannes Gutenberg University Mainz, Langenbeckstr 1, 55101 Mainz, Germany
    Biomed Mater 3:015007. 2008
    ..The in vitro data support recent in vivo studies and indicate that this calcium phosphate/SiO2-xerogel composite could be a useful scaffold material for tissue engineering...
  26. ncbi request reprint Metallic nanoparticles exhibit paradoxical effects on oxidative stress and pro-inflammatory response in endothelial cells in vitro
    K Peters
    Institute of Pathology, Johannes Gutenberg University, Mainz, Germany
    Int J Immunopathol Pharmacol 20:685-95. 2007
    ..These paradoxical responses to different metallic nanoparticles and ions demonstrate the complexity of nanoparticle-induced effects and suggest the need to design new strategies for nanoparticle toxicology...
  27. doi request reprint Expression of E-selectin and vascular cell adhesion molecule-1 in so-called 'negative' appendices: first results to support the pathological diagnosis in borderline cases
    C Brochhausen
    Institute of Pathology, University Medical Centre Mainz, Mainz, Germany brochhausen pathologie klinik uni mainz de
    Eur Surg Res 45:350-5. 2010
    ..Therefore, it was of interest to determine whether the 'negative' appendix correlated with the absence of E-selectin or vascular cell adhesion molecule-1 (VCAM-1)...
  28. doi request reprint [Littoral cell angioma of the spleen. Association with colon and hepatocellular carcinoma]
    T Hansen
    Institut fur Pathologie, Universitätsmedizin Mainz, Langenbeckstr 1, 55101, Mainz, Deutschland
    Pathologe 31:290-2. 2010
    ..In addition a hepatocellular carcinoma was found. Due to the relationship with malignant tumors littoral cell angioma should be considered in every case of a splenic tumoral space-occupying mass, particularly in carcinoma patients...
  29. ncbi request reprint Western blotting as a method for studying cell-biomaterial interactions: the role of protein collection
    T G van Kooten
    Institute of Pathology, Johannes Gutenberg University, Mainz, Germany
    J Biomed Mater Res 54:385-9. 2001
    ..Western blotting of lysates of cells obtained through enzymatic harvest therefore can only be used with internal controls for the assessment of artifacts introduced by trypsinization, or alternative methods should be sought...
  30. ncbi request reprint The role of tumor vascularisation in benign and malignant cardiovascular neoplasms: a comparison of cardiac myxoma and sarcomas of the pulmonary artery
    Andreas Gaumann
    Institut fur Pathologie, Klinikum der Universitat Regensburg, D 93053 Regensburg, Germany
    Oncol Rep 20:309-18. 2008
    ..Hypoxia appears to be the strongest inducer of neoangiogenesis in the sarcomas. The expression of receptor tyrosine kinases of the VEGF family provides a basis for an adjuvant therapy...
  31. ncbi request reprint Tumorigenic conversion of endothelial cells
    Vera Krump-Konvalinkova
    Institute of Pathology, Johannes Gutenberg University Mainz, Germany
    Exp Mol Pathol 75:154-9. 2003
    ..This observation has implications for development of therapeutic approaches for angiosarcoma...
  32. doi request reprint [Rectal goblet cell carcinoid. Primary tumor or metastasis?]
    K Krümpelmann
    Institut fur Pathologie, Universitätsmedizin Mainz, Langenbeckstr 1, 55131, Mainz, Deutschland
    Pathologe 34:65-9. 2013
    ..It is generally recommended to exclude metastasis of a primary appendiceal neoplasm. However, since the patient underwent an appendectomy in 1974, primary origin in the rectum is favored...
  33. ncbi request reprint Growth of human cells on polyethersulfone (PES) hollow fiber membranes
    R E Unger
    Institute of Pathology, Johannes Gutenberg University, Mainz, Langenbeckstr 1, 55101, Mainz, Germany
    Biomaterials 26:1877-84. 2005
    ..Thus, PES is a substrate for the growth of many different types of human cells and may be a useful scaffolding material for tissue engineering...
  34. ncbi request reprint Current trends in biocompatibility testing
    C J Kirkpatrick
    Institute of Pathology, Johannes Gutenberg University, Mainz, Germany
    Proc Inst Mech Eng H 212:75-84. 1998
    ..These include the application of modern techniques of cell and molecular biology, the concepts of tissue remodelling, hybrid organ development and encapsulated cell technology...
  35. ncbi request reprint The Non-neuronal cholinergic system: an emerging drug target in the airways
    I K Wessler
    Institute of Pharmacology, University of Mainz, Obere Zahlbacher Str 67, D 55101 Mainz, Germany
    Pulm Pharmacol Ther 14:423-34. 2001
    ....
  36. doi request reprint [In vitro trials with single and co-cultures of osteoblasts and endothelial cells : evaluation of new biomaterials for bone reconstruction and regeneration]
    R E Unger
    REPAIR Lab, Institut fur Pathologie, Johannes Gutenberg Universitat, Langenbeckstrasse 1, 55133, Mainz, Deutschland
    Orthopade 38:1020-8. 2009
    ..However, in vitro studies offer a good pre-screening and selection basis to evaluate the biocompatibility of novel biomaterials prior to animal studies. Multicell type co-culture systems hold a great promise for the future...
  37. ncbi request reprint Cell type-specific aspects in biocompatibility testing: the intercellular contact in vitro as an indicator for endothelial cell compatibility
    Kirsten Peters
    Institute of Pathology, Johannes Gutenberg University, Langenbeckstr 1, 55101 Mainz, Germany
    J Mater Sci Mater Med 19:1637-44. 2008
    ..Thus, examining the pattern of expression of specific interendothelial contact molecules in vitro may be useful for testing the endothelial cell compatibility of biomaterials and their corrosion products...
  38. ncbi request reprint Establishment and characterization of an angiosarcoma-derived cell line, AS-M
    Vera Krump-Konvalinkova
    Institute of Pathology, Johannes Gutenberg University Mainz, Germany
    Endothelium 10:319-28. 2003
    ..5 presented characteristics suggestive of tumor cells, they did not develop into tumors when inoculated subcutaneously into nude mice. The cell line AS-M.5 could be a useful model system to study endothelial pathobiology in vitro...
  39. ncbi request reprint Response of human endothelial cells to oxidative stress on Ti6Al4V alloy
    Roman Tsaryk
    Institute of Pathology, Johannes Gutenberg University Mainz, Langenbeckstr 1, 55101 Mainz, Germany
    Biomaterials 28:806-13. 2007
    ..However, the exact nature of the agent of oxidative stress generated from Ti6Al4V remains unclear and requires further investigation...
  40. ncbi request reprint Effect of pro-inflammatory stimuli on tumor cell-mediated induction of endothelial cell adhesion molecules in vitro
    N Simiantonaki
    Institute of Pathology, Johannes Gutenberg University, Mainz, Germany
    Exp Mol Pathol 73:46-53. 2002
    ..This might be of special significance in colon carcinomas, where a large source of bacterial LPS is available in the intestinal lumen...
  41. ncbi request reprint Cell-cycle control in cell-biomaterial interactions: expression of p53 and Ki67 in human umbilical vein endothelial cells in direct contact and extract testing of biomaterials
    T G van Kooten
    Institute of Pathology, Johannes Gutenberg University, Langenbeckstrasse 1, 55101 Mainz, Germany
    J Biomed Mater Res 52:199-209. 2000
    ..The p53 marker can be used for defining cell function in more detail, although the correlation with specific physiological function has still to be clarified...
  42. ncbi request reprint Expression of fibronectin splice variants and oncofetal glycosylated fibronectin in the synovial membranes of patients with rheumatoid arthritis and osteoarthritis
    J Kriegsmann
    Institute of Pathology, Trier, Germany
    Rheumatol Int 24:25-33. 2004
    ..The aim of this study was to define and compare the expression of fibronectin (Fn) isoforms in synovial tissue of patients with rheumatoid arthritis (RA) and osteoarthritis (OA)...
  43. ncbi request reprint Day-night rhythm of acetylcholine in the rat pineal gland
    I Wessler
    Department of Pharmacology, University of Mainz, Germany
    Neurosci Lett 224:173-6. 1997
    ..The function of pineal acetylcholine is not clear, but there are indications that acetylcholine may depress noradrenaline release from intrapineal sympathetic fibres and hence melatonin synthesis...
  44. ncbi request reprint Boron determination in liver tissue by combining quantitative neutron capture radiography (QNCR) and histological analysis for BNCT treatment planning at the TRIGA Mainz
    C Schutz
    Institute for Nuclear Chemistry, University of Mainz, Fritz Strassmann Weg 2, D 55099 Mainz, Germany
    Radiat Res 176:388-96. 2011
    ..Methodological aspects of the combination of these techniques and results from four patients enrolled in the study are presented that indicate that the uptake of p-borono-phenylalanine strongly depends on the metabolic activity of cells...
  45. ncbi request reprint The biological role of non-neuronal acetylcholine in plants and humans
    I Wessler
    Department of Pharmacology, University of Mainz, Germany
    Jpn J Pharmacol 85:2-10. 2001
    ....
  46. ncbi request reprint [Cystic myoepithelioma. A rare differential diagnosis of a cystic lesion of the parotid gland]
    T Hansen
    Institut für Pathologie der Johannes Gutenberg Universität Mainz
    HNO 52:1001-3, 1005. 2004
    ..The differential diagnoses are reviewed and discussed. Treatment is by surgical resection. Because of the tendency of myoepitheliomas to recur and to malignant transformation, tumor-free margins are recommended...
  47. ncbi request reprint The cholinergic 'pitfall': acetylcholine, a universal cell molecule in biological systems, including humans
    I Wessler
    Institute of Pharmacology, University of Mainz, Germany
    Clin Exp Pharmacol Physiol 26:198-205. 1999
    ..The involvement of the non-neuronal cholinergic system in the pathogenesis of chronic inflammatory diseases should be investigated to open up new therapeutic strategies...
  48. ncbi request reprint Cyclooxygenases (COX-1 and COX-2) for tissue engineering of articular cartilage--from a developmental model to first results of tissue and scaffold expression
    Christoph Brochhausen
    REPAIRlab, Institute of Pathology, Johannes Gutenberg University, Mainz, Germany
    Biomed Mater Eng 18:15-23. 2008
    ....
  49. ncbi request reprint Microvessel density and VEGF/VEGF receptor status and their role in sarcomas of the pulmonary artery
    Andreas K A Gaumann
    Universitäts klinikum Regensburg, Institut fur Pathologie, Franz Josef Strauss Allee 11, Regensburg, Germany
    Oncol Rep 19:309-18. 2008
    ..Overall and relapse-free survival showed no difference concerning all examined parameters. Thus, microvessel density does not seem to be a prognostic factor in SPA and other sarcomas...
  50. ncbi request reprint Actinomycosis of the jaws--histopathological study of 45 patients shows significant involvement in bisphosphonate-associated osteonecrosis and infected osteoradionecrosis
    Torsten Hansen
    Institute of Pathology, University of Mainz, Langenbeckstr 1, 55101, Mainz, Germany
    Virchows Arch 451:1009-17. 2007
    ..Patients with Actinomycosis of the jaws during or after these forms of anti-cancer therapy are suggested to represent a distinct patient cohort with a relevant impairment of their general condition...
  51. pmc Gold nanoparticles induce cytotoxicity in the alveolar type-II cell lines A549 and NCIH441
    Chiara Uboldi
    Institute of Pathology REPAIR Lab, University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
    Part Fibre Toxicol 6:18. 2009
    ..abstract:..
  52. doi request reprint Recurrence of pleomorphic adenoma of the parotid gland--predictive value of cadherin-11 and fascin
    Juergen Brieger
    Department of Otorhinolaryngology, Head and Neck Surgery, Johannes Gutenberg University, Mainz, Germany
    APMIS 116:1050-7. 2008
    ..Our observations might reflect dysregulation of cellular pathways contributing to cellular dissemination, which might potentially result in later recurrence...
  53. doi request reprint Influence of β-tricalcium phosphate granule size and morphology on tissue reaction in vivo
    Shahram Ghanaati
    Institute of Pathology, REPAIR Laboratory, Johannes Gutenberg University Mainz, 55101 Mainz, Germany
    Acta Biomater 6:4476-87. 2010
    ..This study demonstrates that variations in the physical properties of a bone substitute material clearly influence the (extent of the) inflammatory reaction and its consequences...
  54. doi request reprint Collagen-embedded hydroxylapatite-beta-tricalcium phosphate-silicon dioxide bone substitute granules assist rapid vascularization and promote cell growth
    Shahram M Ghanaati
    Institute of Pathology, Johannes Gutenberg University Mainz, Germany
    Biomed Mater 5:25004. 2010
    ..This manuscript describes successful osteoblastic growth promotion in vitro and a promising biomaterial integration and vasculogenesis in vivo for a possible therapeutic application of this biomatrix in future clinical studies...
  55. doi request reprint Evaluation of the tissue reaction to a new bilayered collagen matrix in vivo and its translation to the clinic
    Shahram Ghanaati
    Institute of Pathology, Johannes Gutenberg University, Mainz, Germany
    Biomed Mater 6:015010. 2011
    ....
  56. doi request reprint Expression of podoplanin in Warthin tumours
    Torsten Hansen
    Institute of Pathology, University Medical Center, Johannes Gutenberg University of Mainz, Langenbeckstr 1, 55101 Mainz, Germany
    Oral Maxillofac Surg 14:223-6. 2010
    ..Warthin tumour is the second most common benign tumour of the parotid gland. This study was designed to investigate the lymphatic vessels in Warthin tumours in an effort to understand better its pathogenesis...
  57. pmc An impaired alveolar-capillary barrier in vitro: effect of proinflammatory cytokines and consequences on nanocarrier interaction
    Maria Iris Hermanns
    Institute of Pathology, Medical University of Mainz, Johannes Gutenberg University, Langenbeckstrasse 1, Mainz 55101, Germany
    J R Soc Interface 7:S41-54. 2010
    ..Our model will be suitable to systematically study adsorption, uptake and trafficking of newly synthesized nanosized carriers under different physiological conditions...
  58. pmc Dynamic in vivo biocompatibility of angiogenic peptide amphiphile nanofibers
    Shahram Ghanaati
    Institute of Pathology, Langenbeckstr 1, Johannes Gutenberg University, 55101 Mainz, Germany
    Biomaterials 30:6202-12. 2009
    ..The observed biocompatibility and development of new vascularized tissue using both techniques demonstrates the potential of these angiogenesis-promoting materials for a host of regenerative strategies...
  59. doi request reprint Signalling molecules and growth factors for tissue engineering of cartilage-what can we learn from the growth plate?
    Christoph Brochhausen
    REPAIR Lab, Institute of Pathology, Johannes Gutenberg University, Langenbeckstrasse 1, 55101 Mainz, Germany
    J Tissue Eng Regen Med 3:416-29. 2009
    ....
  60. doi request reprint Primary human coculture model of alveolo-capillary unit to study mechanisms of injury to peripheral lung
    Maria Iris Hermanns
    Institute of Pathology, Mainz University Clinic, Johannes Gutenberg University, Langenbeckstrasse 1, 55101, Mainz, Germany
    Cell Tissue Res 336:91-105. 2009
    ..The compartmentalization of the barrier-forming bilayer also allows mechanisms of lung injury to be studied in both the epithelial (intra-alveolar) and the endothelial (intravascular) compartments...
  61. doi request reprint The rapid anastomosis between prevascularized networks on silk fibroin scaffolds generated in vitro with cocultures of human microvascular endothelial and osteoblast cells and the host vasculature
    Ronald E Unger
    Institute of Pathology, REPAIR Lab, Johannes Gutenberg University, Langenbeckstrasse 1, Mainz, Germany
    Biomaterials 31:6959-67. 2010
    ..Thus, this coculture-based pre-vascularization of a biomaterial implant may have great potential in the clinical setting to treat large bone defects...
  62. ncbi request reprint Microvessel-like structures from outgrowth endothelial cells from human peripheral blood in 2-dimensional and 3-dimensional co-cultures with osteoblastic lineage cells
    Sabine Fuchs
    Institute of Pathology, Johannes Gutenberg University, Mainz, Germany
    Tissue Eng 13:2577-88. 2007
    ..Based on these observations, we conclude that OECs could provide a valuable source of autologous endothelial cells for the generation of complex tissue-engineered tissues...
  63. ncbi request reprint New aspects in the histological examination of polyethylene wear particles in failed total joint replacements
    Torsten Hansen
    Institute of Pathology, Johannes Gutenberg University, Mainz, Germany
    Acta Histochem 104:263-9. 2002
    ..We also established that immunohistochemical methods can be applied together with the oil red staining method...
  64. ncbi request reprint Isolation and molecular characterization of brain microvascular endothelial cells from human brain tumors
    Ronald E Unger
    Institute of Pathology, Uni Klinik Mainz, University of Mainz, Langenbeckstrasse 1, Germany
    In Vitro Cell Dev Biol Anim 38:273-81. 2002
    ....
  65. ncbi request reprint Molecular basis of endothelial dysfunction in sepsis
    Kirsten Peters
    Institute of Pathology, Johannes Gutenberg University of Mainz, Langenbeckstr 1, 55101, Mainz, Germany
    Cardiovasc Res 60:49-57. 2003
    ..g. endotoxins), cellular targets of these molecules and their responses, host reactions, intracellular and cytokine networks, individual susceptibility and new therapeutic targets in sepsis treatment...
  66. ncbi request reprint Effects of nano-scaled particles on endothelial cell function in vitro: studies on viability, proliferation and inflammation
    Kirsten Peters
    Institute of Pathology, Johannes Gutenberg University, Langenbeckstr 1, 55101 Mainz, Germany
    J Mater Sci Mater Med 15:321-5. 2004
    ..If a pro-inflammatory stimulation of endothelial cells occurs in vivo, a chronic inflammation could be a possible consequence...
  67. ncbi request reprint Paradoxical effects of hypoxia-mimicking divalent cobalt ions in human endothelial cells in vitro
    Kirsten Peters
    Institute of Pathology, Johannes Gutenberg University, Langenbeckstr 1, 55101 Mainz, Germany
    Mol Cell Biochem 270:157-66. 2005
    ..01 mM). This led to the conclusion that although hypoxia signaling after Co2+ -exposure took place, further yet unknown Co2+ -induced event(s) must have occurred...
  68. ncbi request reprint Particulate matter contamination of intravenous antibiotics aggravates loss of functional capillary density in postischemic striated muscle
    Hans Anton Lehr
    Institute of Pathology, University of Mainz, Germany
    Am J Respir Crit Care Med 165:514-20. 2002
    ..e., after trauma, major surgery, or sepsis) and thus predispose to complications such as acute respiratory distress syndrome or multiple organ failure...
  69. ncbi request reprint Software-supported image quantification of angiogenesis in an in vitro culture system: application to studies of biocompatibility
    Kirsten Peters
    Institute of Pathology, Johannes Gutenberg University, Mainz, Germany
    Biomaterials 23:3413-9. 2002
    ..The quantification of the cobalt/ion-exerted effects on angiogenesis in vitro was performed using a contrast-rich vital staining and analysed by software-supported image quantification...
  70. ncbi request reprint [Atherosclerosis--progression by nonspecific activation of the immune system]
    Hans Anton Lehr
    Institut für Pathologie der Johannes Gutenberg Universität Mainz
    Med Klin (Munich) 97:229-35. 2002
    ..The new concept takes us into the responsibility--puts us in charge of our own and our patients' cardiovascular risk--whether we like it or not. The smoking obese doctor no longer fits into the modern medical landscape...
  71. ncbi request reprint Increased numbers of osteoclasts expressing cysteine proteinase cathepsin K in patients with infected osteoradionecrosis and bisphosphonate-associated osteonecrosis--a paradoxical observation?
    Torsten Hansen
    Institute of Pathology, Johannes Gutenberg University of Mainz, Langenbeckstr 1, 55101, Mainz, Germany
    Virchows Arch 449:448-54. 2006
    ....
  72. ncbi request reprint D2-40 labeling in lymphangiomyoma/lymphangiomyomatosis of the soft tissue: further evidence of lymphangiogenic tumor histogenesis
    Torsten Hansen
    Institute of Pathology, Johannes Gutenberg University of Mainz, Langenbeckstr 1, 55101, Mainz, Germany
    Virchows Arch 450:449-53. 2007
    ..Finally, the use of this commercially available antibody provides an additional help in the differential diagnosis of LAM from other soft tissue tumors...
  73. ncbi request reprint Tissue-like self-assembly in cocultures of endothelial cells and osteoblasts and the formation of microcapillary-like structures on three-dimensional porous biomaterials
    Ronald E Unger
    Institute of Pathology, REPAIR Lab, Johannes Gutenberg University, Mainz 55101, Germany
    Biomaterials 28:3965-76. 2007
    ..Our results underline the necessity to take into account the in situ production of growth factors by invading mesenchymal cells in the regenerative niche...
  74. pmc Biological tolerance of different materials in bulk and nanoparticulate form in a rat model: sarcoma development by nanoparticles
    Torsten Hansen
    Institute of Pathology, Johannes Gutenberg University of Mainz, Langenbeckstr 1, 55101 Mainz, Germany
    J R Soc Interface 3:767-75. 2006
    ..The data from the Co group show that the physical properties (particulate versus bulk form) could have a significant influence on the acceleration of the neoplastic process...
  75. pmc Improving cytocompatibility of Co28Cr6Mo by TiO2 coating: gene expression study in human endothelial cells
    R Tsaryk
    Institute of Pathology, University Medical Center, Johannes Gutenberg University of Mainz, Mainz, Germany
    J R Soc Interface 10:20130428. 2013
    ....
  76. ncbi request reprint Apoptosis causes lumen formation during angiogenesis in vitro
    K Peters
    Institute of Pathology, Johannes Gutenberg University, Langenbeckstrasse 1, 55101 Mainz, Germany
    Microvasc Res 64:334-8. 2002
  77. ncbi request reprint Haemangiopericytoma of the thyroid gland in combination with Hashimoto's disease
    T Hansen
    Institute of Pathology, Johannes Gutenberg, University of Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
    Virchows Arch 445:315-9. 2004
    ..The combination of HP and Hashimoto's disease is most probably a coincidental event. However, this case confirms previous reports demonstrating that in patients with Hashimoto's disease different neoplasias can occur...
  78. pmc Tissue reaction to sealing materials: different view at biocompatibility
    S Ghanaati
    Institute of Pathology, REPAIR Lab, Johannes Gutenberg University, Langenbeckstr 1, 55101 Mainz, Germany
    Eur J Med Res 15:483-92. 2010
    ..The results of this study demonstrate that a potential cytotoxic effect of a sealing material may beneficial in order to have antibacterial properties and induce self degradation when accidentally extruded over the apical foramen...
  79. doi request reprint [Tissue engineering of cartilage and bone : growth factors and signaling molecules]
    C Brochhausen
    REPAIR Lab, Institut fur Pathologie, Universitatsmedizin, Johannes Gutenberg Universitat, Langenbeckstrasse 1, 55101, Mainz, Deutschland
    Orthopade 38:1053-62. 2009
    ..This article discusses some important growth factors in the process of endochondral ossification and demonstrates how this information could be translated into a controlled release system for different tissue engineering strategies...
  80. ncbi request reprint Expression of drug resistance related proteins in sarcomas of the pulmonary artery and poorly differentiated leiomyosarcomas of other origin
    A Gaumann
    Institute of Pathology, University Clinics Mainz, Langenbeckstrasse 1, 55101, Mainz, Germany
    Virchows Arch 442:529-37. 2003
    ..Our findings underline the fact that multiple factors contribute to chemoresistance and that examination of a spectrum of relevant molecules is probably necessary to plan the best therapy...
  81. pmc Release of non-neuronal acetylcholine from the isolated human placenta is mediated by organic cation transporters
    I Wessler
    Department of Pharmacology, Universitat Mainz, Obere Zahlbacher Strasse 67, 55101 Mainz, Germany
    Br J Pharmacol 134:951-6. 2001
    ..7. It is concluded that the release of non-neuronal acetylcholine from the human placenta is mediated via organic cation transporters of the OCT1 and OCT3 subtype...
  82. pmc Acetylcholine beyond neurons: the non-neuronal cholinergic system in humans
    I Wessler
    Institute of Pathology, University Hospital, Johannes Gutenberg University, Mainz, Germany
    Br J Pharmacol 154:1558-71. 2008
    ..Alterations have been detected in inflammatory processes and a pathobiologic role of non-neuronal ACh in different diseases is discussed. The present article reviews recent findings about the non-neuronal cholinergic system in humans...
  83. ncbi request reprint Comparative study of adhesion molecule expression in cultured human macro- and microvascular endothelial cells
    Annette M Müller
    Institute of Pathology, University Clinic Bergmannsheil, Ruhr University Bochum, Bochum, Germany
    Exp Mol Pathol 73:171-80. 2002
    ..Thus, the expression patterns in vitro are only partially transferable to in vivo conditions. The study suggests that E-selectin- and VCAM-coated beads could potentially serve in the isolation process of arteriolar and venular ECs...
  84. ncbi request reprint The influence of the C1-inhibitor BERINERT and the protein-free haemodialysate ACTIHAEMYL20% on the evolution of the depth of scald burns in a porcine model
    U Henze
    Institute of Pathology, Aachen University of Technology, Germany
    Burns 23:473-7. 1997
    ..The favourable effects of C1-INH are explained by the protection of the dermal microcirculation during the acute phase of thermal injury...
  85. ncbi request reprint Expression of KIT (CD117) in biphasic pulmonary blastoma. Novel data on histogenesis
    T Hansen
    Institute of Pathology, Johannes Gutenberg University, Mainz, Germany
    Lung 181:193-200. 2003
    ..The role of CD117 in the pathogenesis of BPB and its possible therapeutic relevance require further investigation...
  86. ncbi request reprint Perspectives for the tissue engineering of cartilage from a biological and biomaterial point of view
    C Brochhausen
    REPAIRlab, Institute of Pathology, Johannes Gutenberg University, Mainz Germany
    J Appl Biomater Biomech 5:70-81. 2007
    ....
  87. doi request reprint Prediction model of lymph node metastasis in superficial esophageal adenocarcinoma and squamous cell cancer including D2-40 immunostaining
    I Gockel
    Department of General and Abdominal Surgery, Johannes Gutenberg University of Mainz, Langenbeckstr 1, Mainz D 55131, Germany
    J Surg Oncol 100:191-8. 2009
    ..It was the aim of our study to establish a model for prediction of lymph node metastases in superficial esophageal cancer...
  88. doi request reprint Exploration of the APC/beta-catenin (WNT) pathway and a histologic classification system for pulmonary artery intimal sarcoma. A study of 18 cases
    A Gaumann
    Institute of Pathology, University of Regensburg, Franz Josef Strauss Allee 11, D 93042, Regensburg, Germany
    Virchows Arch 453:473-84. 2008
    ..Despite myofibroblastic phenotype, APC/beta-catenin pathway changes are rare. Cyclin D1, only expressed in the myxofibrosarcoma-type, is likely transcribed via factors other than beta-catenin...
  89. doi request reprint [Mast cell-rich aluminium granuloma]
    T Hansen
    Institut fur Pathologie, Johannes Gutenberg Universitat Mainz, Langenbeckstrasse 1, 55101, Mainz
    Pathologe 29:311-3. 2008
    ..The histological phenomenon of increased mast cell populations in aluminium granuloma might reflect the association with urticaria, which is probably more frequent than previously reported...
  90. ncbi request reprint Actinomyces in infected osteoradionecrosis--underestimated?
    Torsten Hansen
    Institute of Pathology, Johannes Gutenberg University Mainz, Langenbeckstr 1, D 55101 Mainz, Germany
    Hum Pathol 37:61-7. 2006
    ..From the histopathologic perspective, detection of Actinomyces is important because these bacteria have been shown to be associated with prolonged treatment duration...
  91. pmc Inflammatory and cytotoxic responses of an alveolar-capillary coculture model to silica nanoparticles: comparison with conventional monocultures
    Jennifer Kasper
    University Medical Centre, Institute of Pathology, Mainz, Germany
    Part Fibre Toxicol 8:6. 2011
    ....
  92. doi request reprint [Tubulosquamous vaginal polyp. Case report with respect to histogenesis]
    T Hansen
    Institut fur Pathologie, Universitätsmedizin Mainz, Langenbeckstr 1, 55101, Mainz, Deutschland
    Pathologe 33:157-60. 2012
    ..To our knowledge this is the first report on AR expression in this benign polyp. Our findings confirm the view that tubulosquamous polyp of the vagina is derived from paraurethral Skene's gland...
  93. ncbi request reprint Temperature-controlled high frequency ablation for creation of transmyocardial channels: in vivo validation of a novel method
    U Dietz
    Medical Clinic II, University Hospital, Mainz, Germany
    Cardiology 93:234-41. 2000
    ..We investigated the feasibility and short-term effects of a novel procedure to create intramyocardial channels by means of high frequency (HF) ablation in a rabbit in vivo model...
  94. ncbi request reprint Osteoclast-like giant cell tumor of the pancreas with ductal adenocarcinoma: case report with novel data on histogenesis
    T Hansen
    Institute of Pathology, Johannes Gutenberg University, Mainz, Germany
    Pancreas 25:317-20. 2002
  95. ncbi request reprint Infected osteoradionecrosis of the mandible: follow-up study suggests deterioration in outcome for patients with Actinomyces-positive bone biopsies
    T Hansen
    Institute of Pathology, Johannes Gutenberg University of Mainz, Langenbeckstr 1, D 55101 Mainz, Germany
    Int J Oral Maxillofac Surg 35:1001-4. 2006
    ..Actinomyces positivity defines a subpopulation with a clinically deteriorated course of mandibular IORN...
  96. ncbi request reprint Visions for regenerative medicine: interface between scientific fact and science fiction
    C James Kirkpatrick
    Laboratory for REgenerative PAthology and Interface Research REPAIR lab, Institute of Pathology, Johannes Gutenberg University Mainz, Germany
    Artif Organs 30:822-7. 2006
    ..In addition, much more basic research is necessary in developmental biology and the application of modern cell and molecular biology to biomaterial questions...
  97. doi request reprint Do we truly see what we think we see? The role of cognitive bias in pathological interpretation
    T M Fandel
    Department of Urology, Johannes Gutenberg University School of Medicine, Mainz, Germany
    J Pathol 216:193-200. 2008
    ..We demonstrate for the first time the influence a cognitive bias can have in the generation of an error in diagnostic pathology and highlight a considerable problem in histopathological tumour grading...
  98. doi request reprint Biomaterial-induced sarcomagenesis is not associated with microsatellite instability
    Achim Weber
    Institute of Pathology, Johannes Gutenberg University of Mainz, Langenbeckstr 1, 55101, Mainz, Germany
    Virchows Arch 454:195-201. 2009
    ..Thus, there is no evidence that a mutator phenotype is a hallmark of biomaterial-induced sarcomagenesis...
  99. doi request reprint Crossing frontiers in biomaterials and regenerative medicine. 8th World Biomaterials Congress, 28 May - 1 June, Amsterdam, The Netherlands
    Jos Malda
    Institute of Pathology, Johannes Gutenberg University, Mainz, Germany
    Regen Med 3:765-8. 2008
  100. ncbi request reprint Stable knock-down of the sphingosine 1-phosphate receptor S1P1 influences multiple functions of human endothelial cells
    Vera Krump-Konvalinkova
    Institute for Prevention of Cardiovascular Diseases, Ludwig Maximilian University, Munich, Germany
    Arterioscler Thromb Vasc Biol 25:546-52. 2005
    ..Because S1P1 knockout is lethal in the transgenic mouse, an alternative approach to study the function of S1P1 in endothelial cells is needed...
  101. ncbi request reprint Expression of the endothelial markers PECAM-1, vWf, and CD34 in vivo and in vitro
    Annette M Müller
    Institute of Pathology, University Clinic Bergmannsheil, Ruhr University Bochum, Burkle de la Camp Platz 1, Bochum, 44789 Germany
    Exp Mol Pathol 72:221-9. 2002
    ..Moreover, the need for endothelial markers specific for single microvascular type ECs becomes obvious in order to establish cultures consisting of only one microvascular ECs subpopulation...