R Kiesslich

Summary

Affiliation: University of Mainz
Country: Germany

Publications

  1. ncbi request reprint Chromoscopy-guided endomicroscopy increases the diagnostic yield of intraepithelial neoplasia in ulcerative colitis
    Ralf Kiesslich
    I Medical Clinic, Johannes Gutenberg University of Mainz, Germany
    Gastroenterology 132:874-82. 2007
  2. ncbi request reprint Confocal laser endomicroscopy
    Ralf Kiesslich
    1st Medical Clinic, Johannes Gutenberg University Mainz, Mainz, Germany
    Gastrointest Endosc Clin N Am 15:715-31. 2005
  3. ncbi request reprint Technology insight: confocal laser endoscopy for in vivo diagnosis of colorectal cancer
    Ralf Kiesslich
    I Med Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz, Mainz, Germany
    Nat Clin Pract Oncol 4:480-90. 2007
  4. ncbi request reprint Endoscopic detection of early lower gastrointestinal cancer
    R Kiesslich
    I Med Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz, Langenbeckstr 1, Germany
    Best Pract Res Clin Gastroenterol 19:941-61. 2005
  5. doi request reprint Chromoendoscopy: what is its true value for ulcerative colitis surveillance?
    Ralf Kiesslich
    Endoscopic Unit, I Med Klinik und Poliklinik, Johannes Gutenberg Universitat, Mainz, Germany
    Dig Dis 28:445-51. 2010
  6. doi request reprint New imaging techniques and opportunities in endoscopy
    Ralf Kiesslich
    Department of Internal Medicine, Johannes Gutenberg University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
    Nat Rev Gastroenterol Hepatol 8:547-53. 2011
  7. ncbi request reprint Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo
    Ralf Kiesslich
    First Medical Clinic, Johannes Gutenberg University of Mainz, Mainz, Germany
    Gastroenterology 127:706-13. 2004
  8. ncbi request reprint Methylene blue-aided chromoendoscopy for the detection of intraepithelial neoplasia and colon cancer in ulcerative colitis
    Ralf Kiesslich
    I Medical Clinic, Johannes Gutenberg University of Mainz, Mainz, Germany
    Gastroenterology 124:880-8. 2003
  9. ncbi request reprint [Ceftriaxone versus Levofloxacin for antibiotic therapy in patients with acute cholangitis]
    R Kiesslich
    I Med Klinik und Poliklinik, Johannes Gutenberg Universitat, Mainz
    Z Gastroenterol 41:5-10. 2003
  10. doi request reprint In vivo molecular imaging of somatostatin receptors in pancreatic islet cells and neuroendocrine tumors by miniaturized confocal laser-scanning fluorescence microscopy
    C Fottner
    Department of Endocrinology and Metabolism, I Medical Clinic, University of Mainz, Mainz, Germany
    Endocrinology 151:2179-88. 2010

Collaborators

Detail Information

Publications78

  1. ncbi request reprint Chromoscopy-guided endomicroscopy increases the diagnostic yield of intraepithelial neoplasia in ulcerative colitis
    Ralf Kiesslich
    I Medical Clinic, Johannes Gutenberg University of Mainz, Germany
    Gastroenterology 132:874-82. 2007
    ..In this study we assessed the value of combined chromoscopy and endomicroscopy for the diagnosis of intraepithelial neoplasias in a randomized controlled trial...
  2. ncbi request reprint Confocal laser endomicroscopy
    Ralf Kiesslich
    1st Medical Clinic, Johannes Gutenberg University Mainz, Mainz, Germany
    Gastrointest Endosc Clin N Am 15:715-31. 2005
    ..This review describes the optical and diagnostic possibilities of confocal laser endomicroscopy...
  3. ncbi request reprint Technology insight: confocal laser endoscopy for in vivo diagnosis of colorectal cancer
    Ralf Kiesslich
    I Med Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz, Mainz, Germany
    Nat Clin Pract Oncol 4:480-90. 2007
    ..Taken together, CLE has led colorectal cancer endoscopy into a new era. CLE can no longer be regarded as just another endoscopic technique, but emerges as a crucial novel imaging technique for in vivo diagnosis of colorectal cancer...
  4. ncbi request reprint Endoscopic detection of early lower gastrointestinal cancer
    R Kiesslich
    I Med Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz, Langenbeckstr 1, Germany
    Best Pract Res Clin Gastroenterol 19:941-61. 2005
    ..This review summarises newly available technologies and clinical data about the diagnosis of early lower gastrointestinal cancers...
  5. doi request reprint Chromoendoscopy: what is its true value for ulcerative colitis surveillance?
    Ralf Kiesslich
    Endoscopic Unit, I Med Klinik und Poliklinik, Johannes Gutenberg Universitat, Mainz, Germany
    Dig Dis 28:445-51. 2010
    ....
  6. doi request reprint New imaging techniques and opportunities in endoscopy
    Ralf Kiesslich
    Department of Internal Medicine, Johannes Gutenberg University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
    Nat Rev Gastroenterol Hepatol 8:547-53. 2011
    ..Furthermore, functional and molecular imaging are emerging as new diagnostic tools that could provide an opportunity for personalized medicine, in which endoscopy will define disease outcome or predict the response to targeted therapy...
  7. ncbi request reprint Confocal laser endoscopy for diagnosing intraepithelial neoplasias and colorectal cancer in vivo
    Ralf Kiesslich
    First Medical Clinic, Johannes Gutenberg University of Mainz, Mainz, Germany
    Gastroenterology 127:706-13. 2004
    ..The aim of the present study was to assess its potential for prediction of histology during screening colonoscopy for colorectal cancer...
  8. ncbi request reprint Methylene blue-aided chromoendoscopy for the detection of intraepithelial neoplasia and colon cancer in ulcerative colitis
    Ralf Kiesslich
    I Medical Clinic, Johannes Gutenberg University of Mainz, Mainz, Germany
    Gastroenterology 124:880-8. 2003
    ..We performed a randomized, controlled trial to test whether chromoendoscopy (CE) might facilitate early detection of IN and CRC in UC...
  9. ncbi request reprint [Ceftriaxone versus Levofloxacin for antibiotic therapy in patients with acute cholangitis]
    R Kiesslich
    I Med Klinik und Poliklinik, Johannes Gutenberg Universitat, Mainz
    Z Gastroenterol 41:5-10. 2003
    ..The aim of the current study was to compare intravenous therapy of acute cholangitis with Ceftriaxone or Levofloxacin in a prospective and randomized fashion...
  10. doi request reprint In vivo molecular imaging of somatostatin receptors in pancreatic islet cells and neuroendocrine tumors by miniaturized confocal laser-scanning fluorescence microscopy
    C Fottner
    Department of Endocrinology and Metabolism, I Medical Clinic, University of Mainz, Mainz, Germany
    Endocrinology 151:2179-88. 2010
    ..CLM with OcF permits real-time molecular, functional, and morphological imaging of sstr-expressing cell structures, allowing the specific visualization of pancreatic islet cells and neuroendocrine tumors in vivo...
  11. pmc Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease
    R Kiesslich
    Medical Department, Johannes Gutenberg University of Mainz, Mainz, Germany
    Gut 61:1146-53. 2012
    ..The objectives of the study were (1) to determine whether cell shedding and barrier loss in humans can be detected by confocal endomicroscopy and (2) whether these parameters predict relapse of IBD...
  12. doi request reprint Dynamic in vivo imaging of microvasculature and perfusion by miniaturized confocal laser microscopy
    M Goetz
    First Medical Clinic, University of Mainz, Mainz, Germany
    Eur Surg Res 41:290-7. 2008
    ..We evaluated a novel miniaturized confocal laser scanning probe for in vivo visualization of blood vessels, blood flow, cell tracking and perfusion in both healthy rodents and disease models...
  13. doi request reprint MedJet--a new CO2-based disposable cleaning device allows safe and effective bowel cleansing during colonoscopy: a pilot study
    R Kiesslich
    I Med Klinik, Universitätsmedizin Mainz, Langenbeckstrasse 1, Mainz, Germany
    Endoscopy 44:767-71. 2012
    ..The aim of the current pilot study, which was conducted in humans, was to test the safety and efficiency of a newly developed disposable cleaning device, the MedJet, for intraprocedural bowel cleansing...
  14. doi request reprint High definition colonoscopy combined with i-Scan is superior in the detection of colorectal neoplasias compared with standard video colonoscopy: a prospective randomized controlled trial
    A Hoffman
    I Med Clinic, Johannes Gutenberg University of Mainz, Langenbeckstrasse 1, Mainz, Germany
    Endoscopy 42:827-33. 2010
    ..standard video colonoscopy. The primary endpoint was the detection of patients having colon cancer or at least one adenoma...
  15. ncbi request reprint [Interventional ERCP in patients with cholestasis. Degree of biliary bacterial colonization and antibiotic resistance]
    R Kiesslich
    I Med Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz, Germany
    Z Gastroenterol 39:985-92. 2001
    ..2 %) exhibited the lowest rate of in-vitro resistance. Based on these data, the implementation of Levofloxacin in combination with anaerobic coverage is advantageous as a calculated therapy for patients with acute cholangitis...
  16. pmc Surveillance colonoscopy in ulcerative colitis: magnifying chromoendoscopy in the spotlight
    R Kiesslich
    I Med Clinic, Johannes Gutenberg University Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
    Gut 53:165-7. 2004
  17. doi request reprint In vivo confocal laser endomicroscopy of the human liver: a novel method for assessing liver microarchitecture in real time
    M Goetz
    First Medical Clinic, University of Mainz, Mainz, Germany
    Endoscopy 40:554-62. 2008
    ..We have developed a rigid miniaturized probe for confocal endomicroscopy of the human liver during laparoscopy...
  18. ncbi request reprint Confocal laser endomicroscopy: technical status and current indications
    A Hoffman
    First Dept of Medicine, Johannes Gutenberg University, Mainz, Germany
    Endoscopy 38:1275-83. 2006
    ..Molecular imaging is becoming feasible, and this will shortly open the door to new indications in gastrointestinal endoscopy (e.g., in vivo receptor analysis)...
  19. ncbi request reprint Acetic acid-guided biopsies after magnifying endoscopy compared with random biopsies in the detection of Barrett's esophagus: a prospective randomized trial with crossover design
    A Hoffman
    I Med Clinic und Poliklinik, Institute for Statistics, Johannes Gutenberg University Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
    Gastrointest Endosc 64:1-8. 2006
    ..In contrast to standard video endoscopy, magnifying endoscopy after local acetic acid application enables recognition of mucosal surface architecture...
  20. ncbi request reprint In-vivo confocal real-time mini-microscopy in animal models of human inflammatory and neoplastic diseases
    M Goetz
    Medical Clinic I, University of Mainz, Mainz, Germany
    Endoscopy 39:350-6. 2007
    ..In this study we evaluated a newly developed, handheld, miniaturized confocal laser microscopy probe for real-time in-vivo molecular and subsurface imaging in rodent models of human disease...
  21. pmc In vivo imaging of colitis and colon cancer development in mice using high resolution chromoendoscopy
    C Becker
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
    Gut 54:950-4. 2005
    ..In the past, mice had to be sacrificed in order to analyse colitis activity and tumour development. We have developed a safe method for high resolution endoscopic monitoring of living mice...
  22. ncbi request reprint Chromoendoscopy with indigocarmine improves the detection of adenomatous and nonadenomatous lesions in the colon
    R Kiesslich
    I Med. Klinik und Poliklinik, , Mainz, Germany
    Endoscopy 33:1001-6. 2001
    ..The pit pattern seen after staining allows differentiation between hyperplastic and adenomatous lesions which may have consequences with regard to the endoscopic interventions needed...
  23. ncbi request reprint Perspectives of chromo and magnifying endoscopy: how, how much, when, and whom should we stain?
    R Kiesslich
    I Med Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
    J Clin Gastroenterol 38:7-13. 2004
    ..The new detailed images seen with magnifying chromoendoscopy are unequivocally the beginning of a new era where new optical developments will allow a unique look on cellular structures...
  24. ncbi request reprint Screening for specialized columnar epithelium with methylene blue: chromoendoscopy in patients with Barrett's esophagus and a normal control group
    R Kiesslich
    Department of Internal Medicine, St. Hildegardis Hospital, Academic Teaching Hospital of the Johannes-Gutenberg University, Mainz, Germany
    Gastrointest Endosc 53:47-52. 2001
    ..For detection of dysplastic or malignant areas it is important to look for visible mucosal changes...
  25. doi request reprint Methylene blue-aided cholangioscopy in patients with biliary strictures: feasibility and outcome analysis
    A Hoffman
    Medical Clinic I, Johannes Gutenberg University of Mainz, Mainz, Germany
    Endoscopy 40:563-71. 2008
    ..We tested the value of chromoendoscopy during choledochoscopy for characterization of local inflammation, neoplasias, and other alterations in patients with biliary strictures...
  26. ncbi request reprint [Ulcerative colitis--how can endoscopic observation be improved?]
    R Kiesslich
    I Med Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz
    Dtsch Med Wochenschr 128:S139-41. 2003
  27. doi request reprint Molecular imaging of VEGF in gastrointestinal cancer in vivo using confocal laser endomicroscopy
    Sebastian Foersch
    Medical Clinic I, University of Mainz, Mainz, Germany
    Gut 59:1046-55. 2010
    ..The aim of the study was to evaluate CLE for in vivo molecular imaging of VEGF in GiC...
  28. doi request reprint In vivo molecular imaging with cetuximab, an anti-EGFR antibody, for prediction of response in xenograft models of human colorectal cancer
    M Goetz
    I Medizinische Klinik und Poliklinik, Universtitäsmedizin Mainz, Mainz, Germany
    Endoscopy 45:469-77. 2013
    ....
  29. ncbi request reprint Value of chromoendoscopy and magnification endoscopy in the evaluation of duodenal abnormalities: a prospective, randomized comparison
    R Kiesslich
    Dept of Medicine I, Johannes Gutenberg University, Mainz, Germany
    Endoscopy 35:559-63. 2003
    ..The aim of this prospective study was to investigate chromoendoscopy and magnification endoscopy for the evaluation of mucosal lesions in the duodenum...
  30. doi request reprint Simultaneous confocal laser endomicroscopy and chromoendoscopy with topical cresyl violet
    Martin Goetz
    I Medical Clinic, University of Mainz, Mainz, Germany
    Gastrointest Endosc 70:959-68. 2009
    ..Usually fluorescein then serves as a contrast agent for CLE, but it does not allow direct nuclear visualization, must be injected, leads to a transient skin discoloration, and may have allergic side effects...
  31. ncbi request reprint Diagnosing Helicobacter pylori in vivo by confocal laser endoscopy
    Ralf Kiesslich
    I Medical Clinic, Johannes Gutenberg University of Mainz, Germany
    Gastroenterology 128:2119-23. 2005
    ..Confocal laser endomicroscopy enables subsurface microscopic imaging of living tissue during ongoing endoscopy. This case report describes the in vivo detection of Helicobacter pylori by endomicroscopy...
  32. ncbi request reprint Crohn's-like colitis in a patient with immunodeficiency associated with a defect in expression of inducible costimulator
    Jonas Mudter
    First Medical Clinic, Johannes Gutenberg University, Mainz, Germany
    Dig Dis Sci 51:711-7. 2006
  33. doi request reprint Virtual histology
    Ralf Kiesslich
    I Med Department, Johannes Gutenberg University of Mainz, Germany
    Best Pract Res Clin Gastroenterol 22:883-97. 2008
    ..This chapter reviews the currently rapidly expanding clinical data about endomicroscopy and gives a look into future research...
  34. doi request reprint A 9-year retained T-tube fragment encased within a stone as a rare cause of jaundice
    A Hoffman
    1st Medical Clinic, Johannes Gutenberg University of Mainz, Mainz, Germany
    Z Gastroenterol 46:700-3. 2008
    ..This case suggests that plastic material accidentally left in the common bile duct favours the development of large biliary casts when present over long periods of time...
  35. pmc Endoscopic mucosal resection: an evolving therapeutic strategy for non-polypoid colorectal neoplasia
    R Kiesslich
    I Med Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
    Gut 53:1222-4. 2004
  36. ncbi request reprint [Endosonography of the gastrointestinal tract]
    M Moehler
    I Medizinische Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz, Mainz, Deutschland
    Chirurg 78:420-2, 424-7. 2007
    ..The present review discusses current standards of EUS and endosonographically guided therapy and discusses newly available imaging modalities...
  37. ncbi request reprint [Endomicroscopy--technology with future]
    R Kiesslich
    I Medizinische Klinik, Johannes Gutenberg Universitat, Langenbeckstrasse 1, 55131 Mainz
    Internist (Berl) 47:8-17. 2006
    ....
  38. ncbi request reprint Magnifying chromoendoscopy for the detection of premalignant gastrointestinal lesions
    R Kiesslich
    I Med Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
    Best Pract Res Clin Gastroenterol 20:59-78. 2006
    ..This review summarises the value of magnifying endoscopy in the upper and lower gastrointestinal tract and focuses on gastroesophageal reflux disease and early gastric and colorectal cancer...
  39. ncbi request reprint Is chromoendoscopy the new standard for cancer surveillance in patients with ulcerative colitis?
    Markus F Neurath
    I Medical Clinic and Institute of Molecular Medicine, Johannes Gutenberg University of Mainz, Mainz, Germany
    Nat Clin Pract Gastroenterol Hepatol 6:134-5. 2009
    ....
  40. ncbi request reprint Confocal endomicroscopy: in vivo diagnosis of neoplastic lesions of the gastrointestinal tract
    Martin Goetz
    First Med Clinic, Johannes Gutenberg University Mainz, 55131 Mainz, Germany
    Anticancer Res 28:353-60. 2008
    ..Confocal endomicroscopy is evolving as a novel technique for rapid intravital diagnosis of gastrointestinal neoplastic diseases at the microscopic level and bears the potential for molecular imaging in humans in the future...
  41. doi request reprint In vivo molecular imaging of colorectal cancer with confocal endomicroscopy by targeting epidermal growth factor receptor
    Martin Goetz
    I Medizinische Klinik und Poliklinik, Universitätsmedizin Mainz, Mainz, Germany
    Gastroenterology 138:435-46. 2010
    ..Confocal laser endomicroscopy (CLE) enables accurate microscopic visualization of CRC in patients during endoscopy. We evaluated the ability to use CLE in vivo for instantaneous molecular imaging of EGFR in CRC models...
  42. doi request reprint Oncological outcome after local excision of rectal carcinomas
    Thomas Borschitz
    Clinic of General and Abdominal Surgery, Johannes Gutenberg University Hospital, Langenbeckstr 1, 55131 Mainz, Germany
    Ann Surg Oncol 15:3101-8. 2008
    ..However, more frequent recurrences with unknown states of high-risk T1/T2 tumors are risk factors. The purpose of this study was to evaluate if, after LE, immediate reoperation is required, or awaiting salvage surgery is sufficient...
  43. doi request reprint Confocal chromolaser endomicroscopy: a supplemental diagnostic tool prior to transanal endoscopic microsurgery of rectal tumors?
    Thomas Borschitz
    Clinic of General and Abdominal Surgery, Johannes Gutenberg University Hospital, Mainz, Germany
    Int J Colorectal Dis 25:71-7. 2010
    ..The aim of this study was to test if confocal chromolaser endomicroscopy (cCLEM) can help minimize this diagnostic gap...
  44. doi request reprint Confocal endomicroscopy: a novel application for imaging of oral and oropharyngeal mucosa in human
    Boris Rainer Haxel
    Department of Otolaryngology, Head and Neck Surgery, Johannes Gutenberg University, 55101 Mainz, Germany
    Eur Arch Otorhinolaryngol 267:443-8. 2010
    ..This is the first report showing that the use of fluorescence confocal endomicroscopy represents a promising method to examine cellular details in vivo in different oropharyngeal regions in human...
  45. ncbi request reprint Near-infrared confocal imaging during mini-laparoscopy: a novel rigid endomicroscope with increased imaging plane depth
    Martin Goetz
    I Medizinische Klinik und Poliklinik, Universitätsmedizin Mainz, Mainz, Germany
    J Hepatol 53:84-90. 2010
    ..The aim of the current study was to evaluate a novel near-infrared (NIR) light probe with indocyanine green (ICG) contrast for in vivo confocal imaging of the human liver during mini-laparoscopy...
  46. doi request reprint Advances of endomicroscopy for gastrointestinal physiology and diseases
    Martin Goetz
    I Medizinische Klinik und Poliklinik, Universitätsmedizin Mainz, Langenbeckstr 1, 55131 Mainz, Germany
    Am J Physiol Gastrointest Liver Physiol 298:G797-806. 2010
    ..Molecular imaging with endomicroscopy applied in clinical and basic science will permit advances in understanding of the cellular basis of gastrointestinal physiology and pathophysiology...
  47. ncbi request reprint In vivo confocal laser laparoscopy allows real time subsurface microscopy in animal models of liver disease
    Martin Goetz
    I Medizinische Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz, Germany
    J Hepatol 48:91-7. 2008
    ..Therefore a newly developed miniaturised confocal probe was evaluated for in vivo microscopic imaging in rodent models of human liver diseases...
  48. ncbi request reprint In vivo subsurface morphological and functional cellular and subcellular imaging of the gastrointestinal tract with confocal mini-microscopy
    Martin Goetz
    I Medical Clinic, Johannes Gutenberg Universitat, Mainz 55131, Germany
    World J Gastroenterol 13:2160-5. 2007
    ..To evaluate a newly developed hand-held confocal probe for in vivo microscopic imaging of the complete gastrointestinal tract in rodents...
  49. doi request reprint Confocal laser endomicroscopy
    Ralf Kiesslich
    Department of I Med Klinik und Poliklinik, Johannes Gutenberg University, Mainz, Deutschland, Germany
    Gastrointest Endosc Clin N Am 19:261-72. 2009
    ..However, the era of endomicroscopy has just started and it can be anticipated that its role will significantly increase in the future...
  50. ncbi request reprint Endoscopic surveillance in ulcerative colitis: smart biopsies do it better
    Ralf Kiesslich
    Johannes Gutenberg University of Mainz, Mainz, Germany
    Gastroenterology 133:742-5. 2007
  51. ncbi request reprint 6-thioguanosine diphosphate and triphosphate levels in red blood cells and response to azathioprine therapy in Crohn's disease
    Markus F Neurath
    Medical Clinic, University of Mainz, Mainz, Germany
    Clin Gastroenterol Hepatol 3:1007-14. 2005
    ..In this study we assessed the impact of TGTP levels for monitoring of azathioprine therapy...
  52. ncbi request reprint Confocal laser endoscopy: new approach to the early diagnosis of tumors of the esophagus and stomach
    Martin Goetz
    Johannes Gutenberg University Mainz, I Med Clinic, Langenbeckstr1, 55131 Mainz, Germany
    Future Oncol 2:469-76. 2006
    ..Based on recent experiences from animal models, future studies will approach in vivo molecular imaging of human cancer...
  53. ncbi request reprint [Massive hemorrhage in a 28-year-old male patient with intestinal Behçet's disease]
    M Waldner
    I Medizinische Klinik, Johannes Gutenberg Universitat, Mainz
    Z Gastroenterol 44:1047-51. 2006
    ..In addition, no further gastrointestinal hemorrhage occurred. Due to its higher prevalence in patients from eastern Asia, Behçet's disease poses an important differential diagnosis of intestinal hemorrhage in patients of this descent...
  54. ncbi request reprint In-vivo microvascular imaging of early squamous-cell cancer of the esophagus by confocal laser endomicroscopy
    K Deinert
    Department of Internal Medicine, Evangelisches Krankenhaus, Dusseldorf, Germany
    Endoscopy 39:366-8. 2007
    ..Endomicroscopy therefore has the potential to characterize microvascular changes in early squamous-cell cancer, suggesting that this technique might have major implications for optimizing treatment strategies in modern endoscopy...
  55. ncbi request reprint Chromo- and magnifying endoscopy for colorectal lesions
    Ralf Kiesslich
    Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz, Germany
    Eur J Gastroenterol Hepatol 17:793-801. 2005
    ..This review summarizes the value of magnifying endoscopy in the lower gastrointestinal tract and focuses on colorectal lesions...
  56. ncbi request reprint Chromoendoscopy and other novel imaging techniques
    Ralf Kiesslich
    I Med Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
    Gastroenterol Clin North Am 35:605-19. 2006
    ..The new detailed images seen with magnifying chromoendoscopy are the beginning of a new era in which advances in optical development, such as confocal endomicroscopy, allow a unique look at detailed cellular structures...
  57. doi request reprint Confocal laser endomicroscopy for gastrointestinal diseases
    Ralf Kiesslich
    First Department of Internal Medicine, Klinik und Poliklinik, Johannes Gutenberg University of Mainz, Langenbeckstrasse 1, Mainz, Germany
    Gastrointest Endosc Clin N Am 18:451-66, viii. 2008
    ..Molecular imaging is becoming feasible, which will enable new indications in gastrointestinal endoscopy. This article reviews the current and rapidly expanding clinical data on endomicroscopy and gives a look into future research...
  58. pmc Recurrent gastrointestinal haemorrhage from the distal duodenum
    M H Holtmann
    1st Department of Medicine, Johannes Gutenberg University, Langenbeckstrasse 1, 55 131 Mainz, Germany
    Gut 55:1275, 1331. 2006
  59. doi request reprint [Molecular imaging of the small intestine]
    M Goetz
    I Medizinische Klinik und Poliklinik, Universitätsmedizin Mainz, Langenbeckstrasse 1, Mainz, Germany
    Internist (Berl) 51:702-10. 2010
    ..Still, molecular imaging has the potential to greatly enhance our understanding of gastrointestinal pathology and to impact on future clinical algorithms and science in gastroenterology...
  60. ncbi request reprint Use of a duodenoscope in the management of a ureteral calculus in a patient with ureterosigmoidostomy (Mainz pouch II; rectosigmoid pouch)
    P Mosler
    Dept of Medicine I, Johannes Gutenberg University, Mainz, Germany
    Endoscopy 35:1086-7. 2003
  61. ncbi request reprint [Rendezvous technique for complete hypopharyngeal stenosis. Indications and variations of combined endoscopy]
    B Pogorzelski
    HNO Klinik und Poliklinik, Universitatsklinik Mainz, Langenbeckstrasse 1, 55131, Mainz
    HNO 57:781-8. 2009
    ..Antegrade dilatation or puncture and local mitomycin C application are often unsuccessful and many patients require extensive surgery...
  62. ncbi request reprint Endoscopic confocal imaging
    Ralf Kiesslich
    I Med Clinic, Johannes Gutenberg University of Mainz, Germany
    Clin Gastroenterol Hepatol 3:S58-60. 2005
    ..Indications discussed include colorectal cancer evaluation, ulcerative colitis and surveillance, Barrett's esophagus, and detection of Helicobacter pylori infection in vivo...
  63. doi request reprint [Diagnosis and treatment of esophageal cancer]
    R Kiesslich
    Medizinische Klinik und Poliklinik, Universitätsmedizin Mainz, Deutschland
    Internist (Berl) 53:1315-27; quiz 1328-9. 2012
    ..New chemotherapeutic strategies may offer improved survival but may also include new side effects. Patients with inoperable esophageal cancer also benefit from multimodal treatment...
  64. ncbi request reprint Chromoendoscopy in Barrett's oesophagus: is cresyl violet the magic bullet?
    R Kiesslich
    I Med Clinic, Johannes Gutenberg University Mainz, Langenbeckstr 1, 55131 Mainz, Germany
    Dig Liver Dis 38:301-2. 2006
  65. ncbi request reprint [Combined simulation training: a new concept and workshop is useful for crisis management in gastrointestinal endoscopy]
    R Kiesslich
    I Med Klinik und Poliklinik, Johannes Gutenberg Universitat Mainz
    Z Gastroenterol 43:1031-9. 2005
    ..The aim of the current study was to evaluate the efficiency of the newly developed simulation workshop...
  66. ncbi request reprint Chromoendoscopy and magnifying endoscopy in patients with gastroesophageal reflux disease. Useful or negligible?
    Ralf Kiesslich
    1st Medical Clinic, Johannes Gutenberg University of Mainz, Mainz, Germany
    Dig Dis 22:142-7. 2004
    ..However, these techniques have significant potential to improve diagnostic accuracy in patients with Barrett's esophagus...
  67. ncbi request reprint Identification of epithelial gaps in human small and large intestine by confocal endomicroscopy
    Ralf Kiesslich
    I Medical Clinic, University of Mainz, Mainz, Germany
    Gastroenterology 133:1769-78. 2007
    ..The goals of this study were to determine if confocal endomicroscopy could resolve the presence of human epithelial gaps and whether a proinflammatory cytokine could increase cell shedding...
  68. ncbi request reprint Mini-laparoscopically guided percutaneous gastrostomy and jejunostomy
    Ulrike Denzer
    Department of Medicine, Johannes Gutenberg University, Mainz, Germany
    Gastrointest Endosc 58:434-8. 2003
    ..As an alternative in these problematic situations, a technique was developed for placing feeding tubes under visual control by using mini-laparoscopy...
  69. doi request reprint Advanced imaging of the gastrointestinal tract: research vs. clinical tools?
    Martin Goetz
    I Medical Clinic, University of Mainz, Mainz, Germany
    Curr Opin Gastroenterol 25:412-21. 2009
    ..Still, three major needs have to be satisfied: endoscopy should be able to detect a lesion, characterize the lesion, and then its nature should be confirmed. These steps should ideally translate into an immediate therapeutic decision...
  70. ncbi request reprint Methylene blue-aided cholangioscopy unravels the endoscopic features of ischemic-type biliary lesions after liver transplantation
    Arthur Hoffman
    I Medical Clinic, Johannes Gutenberg University, Mainz, Germany
    Gastrointest Endosc 66:1052-8. 2007
  71. ncbi request reprint In vivo histology of Barrett's esophagus and associated neoplasia by confocal laser endomicroscopy
    Ralf Kiesslich
    Medical Clinic, Johannes Gutenberg University Mainz, Germany
    Clin Gastroenterol Hepatol 4:979-87. 2006
    ..Here, we have applied this technique to the in vivo diagnosis of Barrett's epithelium and associated neoplasia...
  72. ncbi request reprint TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling
    Christoph Becker
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
    Immunity 21:491-501. 2004
    ..Taken together, our data provide novel insights into TGF-beta signaling in colorectal cancer and suggest novel therapeutic approaches for colorectal cancer based on inhibition of TGF-beta-dependent IL-6 trans-signaling...
  73. ncbi request reprint A fluorescence confocal endomicroscope for in vivo microscopy of the upper- and the lower-GI tract
    Adrian L Polglase
    Cabrini Monash University Department of Surgery, Cabrini Medical Centre, Malvern, Victoria, Australia
    Gastrointest Endosc 62:686-95. 2005
    ..The work assessed the feasibility of performing in vivo microscopy at endoscopic examination and evaluated fluorescence imaging protocols...
  74. ncbi request reprint Magnifying chromoendoscopy: effective diagnostic tool for screening colonoscopy
    Ralf Kiesslich
    J Gastroenterol Hepatol 22:1700-1. 2007
  75. ncbi request reprint Endomicroscopy is born--do we still need the pathologist?
    Ralf Kiesslich
    Gastrointest Endosc 66:150-3. 2007
  76. doi request reprint Chromoendoscopy and narrow-band imaging compared with high-resolution magnification endoscopy in Barrett's esophagus
    Wouter Curvers
    Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Gastroenterology 134:670-9. 2008
    ....
  77. ncbi request reprint Endoluminal therapy of GERD with a new endoscopic suturing device
    Dieter Schilling
    Department of Gastroenterology and Hepatology, Hosital of Ludwigshafen, Academic Teaching Hospital of the Johannes Gutenberg University of Mainz, D 67063 Ludwigshafen, Germany
    Gastrointest Endosc 62:37-43. 2005
    ..Secondly, 3 and 6 months' follow-ups were performed, and possible complications and their management were evaluated...
  78. ncbi request reprint Drug insight: novel small molecules and drugs for immunosuppression
    Massimo C Fantini
    University of Rome Tor Vergata, Italy
    Nat Clin Pract Gastroenterol Hepatol 3:633-44. 2006
    ..Here, we report on the progress that has been made in the development of small molecules in the field of gastroenterology...