A K Kiemer

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi Induction of IkappaB: atrial natriuretic peptide as a regulator of the NF-kappaB pathway
    Alexandra K Kiemer
    Department of Pharmacy, Center of Drug Research, University of Munich, Butenandtstrasse 5 13, 81377 Munich, Germany
    Biochem Biophys Res Commun 295:1068-76. 2002
  2. ncbi Inhibition of LPS-induced nitric oxide and TNF-alpha production by alpha-lipoic acid in rat Kupffer cells and in RAW 264.7 murine macrophages
    Alexandra K Kiemer
    Department of Pharmacy, Center of Drug Research, University of Munich, Germany
    Immunol Cell Biol 80:550-7. 2002
  3. ncbi Phyllanthus amarus has anti-inflammatory potential by inhibition of iNOS, COX-2, and cytokines via the NF-kappaB pathway
    Alexandra K Kiemer
    Department of Pharmacy, Center of Drug Research, University of Munich, Butenandtstr 5 13, 81377 Munich, Germany
    J Hepatol 38:289-97. 2003
  4. pmc The atrial natriuretic peptide regulates the production of inflammatory mediators in macrophages
    A K Kiemer
    Department of Pharmacy, Centre of Drug Research, University of Munich, Germany
    Ann Rheum Dis 60:iii68-70. 2001
  5. ncbi Inhibition of cyclooxygenase-2 by natriuretic peptides
    Alexandra K Kiemer
    Department of Pharmacy, Center of Drug Research, University of Munich, 81377 Munich, Germany
    Endocrinology 143:846-52. 2002
  6. ncbi The atrial natriuretic peptide and cGMP: novel activators of the heat shock response in rat livers
    Alexandra K Kiemer
    Department of Pharmacy, Center of Drug Research, Klinikum Grosshadern, University of Munich, Munich, Germany
    Hepatology 35:88-94. 2002
  7. ncbi Characterization of heme oxygenase 1 (heat shock protein 32) induction by atrial natriuretic peptide in human endothelial cells
    Alexandra K Kiemer
    Department of Pharmacy, Center of Drug Research, University of Munich, 81377 Munich, Germany
    Endocrinology 144:802-12. 2003
  8. ncbi Induction of L-arginine transport is inhibited by atrial natriuretic peptide: a peptide hormone as a novel regulator of inducible nitric-oxide synthase substrate availability
    A K Kiemer
    Department of Pharmacy, Center of Drug Research, University of Munich, Munich, Germany
    Mol Pharmacol 60:421-6. 2001
  9. ncbi Elevation of intracellular calcium levels contributes to the inhibition of nitric oxide production by atrial natriuretic peptide
    A K Kiemer
    Institute of Pharmacy, Center of Drug Research, Pharmaceutical Biology, University of Munich, Munich, Germany
    Immunol Cell Biol 79:11-7. 2001
  10. ncbi Atrial natriuretic peptide reduces expression of TNF-alpha mRNA during reperfusion of the rat liver upon decreased activation of NF-kappaB and AP-1
    A K Kiemer
    Department of Medicine II, Klinikum Grosshadern, University of Munich, Germany
    J Hepatol 33:236-46. 2000

Collaborators

Detail Information

Publications40

  1. ncbi Induction of IkappaB: atrial natriuretic peptide as a regulator of the NF-kappaB pathway
    Alexandra K Kiemer
    Department of Pharmacy, Center of Drug Research, University of Munich, Butenandtstrasse 5 13, 81377 Munich, Germany
    Biochem Biophys Res Commun 295:1068-76. 2002
    ..The induction of IkappaB by ANP is suggested as a novel mechanism for regulating inflammatory signalling in endothelial cells, leading to reduced TNF-alpha-induced expression of adhesion molecules...
  2. ncbi Inhibition of LPS-induced nitric oxide and TNF-alpha production by alpha-lipoic acid in rat Kupffer cells and in RAW 264.7 murine macrophages
    Alexandra K Kiemer
    Department of Pharmacy, Center of Drug Research, University of Munich, Germany
    Immunol Cell Biol 80:550-7. 2002
    ..The reduced production of nitric oxide and TNF-alpha in Kupffer cells may be involved in the hepatoprotective action conveyed by alpha-lipoic acid...
  3. ncbi Phyllanthus amarus has anti-inflammatory potential by inhibition of iNOS, COX-2, and cytokines via the NF-kappaB pathway
    Alexandra K Kiemer
    Department of Pharmacy, Center of Drug Research, University of Munich, Butenandtstr 5 13, 81377 Munich, Germany
    J Hepatol 38:289-97. 2003
    ..amarus extracts concerning a potential influence of P. amarus on endotoxin-induced nitric oxide synthase (iNOS), cyclooxygenase (COX-2), and cytokine production in vivo and in vitro...
  4. pmc The atrial natriuretic peptide regulates the production of inflammatory mediators in macrophages
    A K Kiemer
    Department of Pharmacy, Centre of Drug Research, University of Munich, Germany
    Ann Rheum Dis 60:iii68-70. 2001
    ..In summary, ANP was shown to reduce the secretion of inflammatory mediators in macrophages. Therefore, this cardiovascular hormone may possess anti-inflammatory potential...
  5. ncbi Inhibition of cyclooxygenase-2 by natriuretic peptides
    Alexandra K Kiemer
    Department of Pharmacy, Center of Drug Research, University of Munich, 81377 Munich, Germany
    Endocrinology 143:846-52. 2002
    ..ANP reduces COX-2-protein and -mRNA levels. The inhibition seems to be mediated via NPR-C and related to an attenuation of cAMP production...
  6. ncbi The atrial natriuretic peptide and cGMP: novel activators of the heat shock response in rat livers
    Alexandra K Kiemer
    Department of Pharmacy, Center of Drug Research, Klinikum Grosshadern, University of Munich, Munich, Germany
    Hepatology 35:88-94. 2002
    ..This could be an important mechanism of ANP-mediated prevention of hepatic preservation damage...
  7. ncbi Characterization of heme oxygenase 1 (heat shock protein 32) induction by atrial natriuretic peptide in human endothelial cells
    Alexandra K Kiemer
    Department of Pharmacy, Center of Drug Research, University of Munich, 81377 Munich, Germany
    Endocrinology 144:802-12. 2003
    ..The aim of this study was to characterize induction of heme oxygenase (HO)-1 by ANP in human umbilical vein endothelial cells (HUVEC)...
  8. ncbi Induction of L-arginine transport is inhibited by atrial natriuretic peptide: a peptide hormone as a novel regulator of inducible nitric-oxide synthase substrate availability
    A K Kiemer
    Department of Pharmacy, Center of Drug Research, University of Munich, Munich, Germany
    Mol Pharmacol 60:421-6. 2001
    ..Recently, we could show that the cardiovascular hormone atrial natriuretic peptide (ANP) inhibits the induction of iNOS in LPS-stimulated macrophages via its guanylate cyclase-coupled A-receptor...
  9. ncbi Elevation of intracellular calcium levels contributes to the inhibition of nitric oxide production by atrial natriuretic peptide
    A K Kiemer
    Institute of Pharmacy, Center of Drug Research, Pharmaceutical Biology, University of Munich, Munich, Germany
    Immunol Cell Biol 79:11-7. 2001
    ..Taken together, the data indicate that intracellular Ca2+ elevation by ANP is involved in the inhibition of LPS-induced nitric oxide production in macrophages...
  10. ncbi Atrial natriuretic peptide reduces expression of TNF-alpha mRNA during reperfusion of the rat liver upon decreased activation of NF-kappaB and AP-1
    A K Kiemer
    Department of Medicine II, Klinikum Grosshadern, University of Munich, Germany
    J Hepatol 33:236-46. 2000
    ..The identification of the mechanisms underlying the protection by ANP should reveal new aspects concerning the pathomechanisms of ischemia/reperfusion injury...
  11. ncbi cGMP-mediated inhibition of TNF-alpha production by the atrial natriuretic peptide in murine macrophages
    A K Kiemer
    Institute of Pharmacy, Center of Drug Research, Pharmaceutical Biology, University of Munich, Germany
    J Immunol 165:175-81. 2000
    ..The inhibition is suggested to involve transcriptional processes that are the result of reduced activation of responsible transcription factors...
  12. ncbi Kupffer-cell specific induction of heme oxygenase 1 (hsp32) by the atrial natriuretic peptide--role of cGMP
    Alexandra K Kiemer
    Department of Pharmacy, Center of Drug Research, University of Munich, Munich, Germany
    J Hepatol 38:490-8. 2003
    ..Heme oxygenase-1 (HO-1) is known as a protective mediator in ischemia-reperfusion injury. The aim of this study was to investigate whether ANP affects the expression of HO-1...
  13. ncbi Stimulation of p38 MAPK by hormonal preconditioning with atrial natriuretic peptide
    Alexandra K Kiemer
    Department of Pharmacy, Center of Drug Research, Butenandtstr 5 13, 81377 Munich, Germany
    World J Gastroenterol 8:707-11. 2002
    ..Circ Res 2002, 90:874-881), aim of this study was to investigate activities of MAPK during ischemia and reperfusion and effects of ANP on MAPK...
  14. ncbi The triterpenoid quinonemethide pristimerin inhibits induction of inducible nitric oxide synthase in murine macrophages
    V M Dirsch
    Institute of Pharmacology, Toxicology and Pharmacy, Ludwig Maximilians University, Munich, Germany
    Eur J Pharmacol 336:211-7. 1997
    ..This feature of pristimerin is likely to contribute to its anti-inflammatory activity...
  15. ncbi Effect of allicin and ajoene, two compounds of garlic, on inducible nitric oxide synthase
    V M Dirsch
    Institute of Pharmacology, Toxicology and Pharmacy, Munich, Germany
    Atherosclerosis 139:333-9. 1998
    ..These observations indicate that allicin and ajoene inhibit the expression of iNOS in activated macrophages. The possible link of this effect to the beneficial features attributed to garlic is discussed...
  16. ncbi Immunomodulatory and cytoprotective function of atrial natriuretic peptide
    A M Vollmar
    Department of Pharmacy, Center of Drug Research, University of Munich, Germany
    Crit Rev Immunol 21:473-85. 2001
    ..The beneficial effect of ANP in preventing cell damage caused by ischemia and reperfusion warrants special attention. The therapeutic potential of ANP in organ preservation could be important for transplantation medicine...
  17. ncbi Identification of genes involved in epithelial-mesenchymal transition and tumor progression
    A K Kiemer
    Department of Pharmacy, Center of Drug Research, University of Munich, Butenandtstr. 5-13, 81377 Munich, Germany
    Oncogene 20:6679-88. 2001
    ..Array analyses indicated that the cDNAs were specifically upregulated in invasive or metastatic tumors, especially of breast, uterus and lung, suggesting their involvement in the progression of these tumors...
  18. ncbi Atrial natriuretic peptide induces mitogen-activated protein kinase phosphatase-1 in human endothelial cells via Rac1 and NAD(P)H oxidase/Nox2-activation
    Robert Fürst
    Department of Pharmacy, University of Munich, Germany
    Circ Res 96:43-53. 2005
    ..In summary, our work provides insights into the mechanisms by which ANP induces MKP-1 and shows that ANP is a novel endogenous activator of endothelial Rac1 and Nox/Nox2...
  19. ncbi Vasoprotective actions of the atrial natriuretic peptide
    Alexandra K Kiemer
    Department of Pharmacy, Center of Drug Research, University of Munich, D 81377 Munich, Germany
    Curr Med Chem Cardiovasc Hematol Agents 3:11-21. 2005
    ..In this context, we will highlight the physiological and pharmacological relevance of NPs, particularly ANP, as endogenous vasoprotective agents...
  20. ncbi Hepatocyte cytoskeleton during ischemia and reperfusion--influence of ANP-mediated p38 MAPK activation
    Melanie Keller
    Department of Pharmacy, Centre of Drug Research, University of Munich, Germany
    World J Gastroenterol 11:7418-29. 2005
    ..To determine functional consequences of this activation, whereby we focused on a potential regulation of the hepatocyte cytoskeleton during ischemia and reperfusion...
  21. ncbi PI 3-kinase pathway is responsible for antiapoptotic effects of atrial natriuretic peptide in rat liver transplantation
    Uwe Grutzner
    Institute for Surgical Research, Klinikum Grosshadern, University of Munich, Germany
    World J Gastroenterol 12:1049-55. 2006
    ..To investigate the in vivo effect of atrial natriuretic peptide (ANP) and its signaling pathway during orthotopic rat liver transplantation...
  22. ncbi Protection from hepatic ischemia/reperfusion injury and improvement of liver regeneration by alpha-lipoic acid
    Friedrich Duenschede
    Department of General and Abdominal Surgery, University Hospital Mainz, Mainz, Germany
    Shock 27:644-51. 2007
    ..Attenuation of IRI of the rat liver in vivo by LA is accompanied by reduction of necrosis and apoptosis-related cell death, whereas liver regeneration is increased...
  23. ncbi Nuclear factor-kappa B-independent anti-inflammatory action of salicylate in human endothelial cells: induction of heme oxygenase-1 by the c-jun N-terminal kinase/activator protein-1 pathway
    Robert Fürst
    Department of Pharmacy, Pharmaceutical Biology, University of Munich, Butenandtstr 5 13, 81377 Munich, Germany
    J Pharmacol Exp Ther 318:389-94. 2006
    ..In summary, our study introduces HO-1 as novel NF-kappaB-independent anti-inflammatory target of salicylate in human endothelial cells. Moreover, we elucidated the JNK/AP-1 pathway as crucial for the induction of HO-1 by salicylate...
  24. ncbi MAPK phosphatase-1 represents a novel anti-inflammatory target of glucocorticoids in the human endothelium
    Robert Fürst
    University of Munich, Department of Pharmacy, Pharmaceutical Biology, Butenandtstr 5 13, 81377 Munich, Germany
    FASEB J 21:74-80. 2007
    ....
  25. ncbi Atrial natriuretic peptide, a regulator of nuclear factor-kappaB activation in vivo
    Kathrin Ladetzki-Baehs
    Department of Pharmacy, Center of Drug Research, University of Munich, Germany
    Endocrinology 148:332-6. 2007
    ..These findings demonstrate both in vitro and in vivo an antiinflammatory profile of ANP that deserves to be further investigated in a therapeutic perspective...
  26. ncbi Protein kinase A dependent signalling mediates anti-apoptotic effects of the atrial natriuretic peptide in ischemic livers
    Stefanie Kulhanek-Heinze
    Department of Pharmacy, Center of Drug Research, University of Munich, Butenandtstr 5 13, 81377 Munich, Germany
    J Hepatol 41:414-20. 2004
    ..Recently, we have shown that ANP affects the p38 MAPK signalling cascade in the liver. Thus, aim of the present study was to elucidate the role of cGMP- and p38 MAPK-dependent signalling pathways in ANP-mediated anti-apoptotic effects...
  27. ncbi ANP-induced decrease of iron regulatory protein activity is independent of HO-1 induction
    Alexandra K Kiemer
    Department of Pharmacy, Center of Drug Research, University of Munich, Germany
    Am J Physiol Gastrointest Liver Physiol 287:G518-26. 2004
    ..This work shows the cGMP-mediated attenuation of IRP binding activity by ANP, which results in increased hepatic ferritin levels. This change in IRPs is independent of ANP-induced HO-1 and reduced PKC activation...
  28. ncbi ANP inhibits TNF-alpha-induced endothelial MCP-1 expression--involvement of p38 MAPK and MKP-1
    Nina C Weber
    Department of Pharmacy, University of Munich, Germany
    J Leukoc Biol 74:932-41. 2003
    ..As antisense experiments revealed a pivotal role for MKP-1 induction and therefore, p38 MAPK inhibition in ANP-mediated attenuation of MCP-1 expression, this action seems to be rather independent of NF-kappaB inhibition...
  29. ncbi Inhibition of p38 MAPK activation via induction of MKP-1: atrial natriuretic peptide reduces TNF-alpha-induced actin polymerization and endothelial permeability
    Alexandra K Kiemer
    Department of Pharmacy, Center of Drug Research, University of Munich, Munich, Germany Alexandra Kiemer cup uni muenchen de
    Circ Res 90:874-81. 2002
    ..These effects point to an antiinflammatory and antiatherogenic potential of this cardiovascular hormone...
  30. ncbi The atrial natriuretic peptide as a regulator of Kupffer cell functions
    Alexandra K Kiemer
    Department of Pharmacy, Center of Drug Research, Munich, Germany
    Shock 17:365-71. 2002
    ..In addition, we demonstrated that ANP enhances phagocytosis in KCs. These effects may contribute to the hepatoprotective actions of ANP...
  31. ncbi In vivo regulation of inducible no synthase in immune-mediated liver injury in mice
    Kerstin Koerber
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nuremberg, Germany
    Hepatology 36:1061-9. 2002
    ..Although con A-induced liver injury depends on both TNFR1 and TNFR2, TNF-dependent iNOS expression is mediated exclusively by TNFR1 and requires NF-kappaB activation...
  32. ncbi Parenchymal, but not leukocyte, TNF receptor 2 mediates T cell-dependent hepatitis in mice
    Jens Schumann
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Fahrstrasse 17, DE 91054 Erlangen, Germany
    J Immunol 170:2129-37. 2003
    ..Our results suggest that parenchymal, but not leukocyte, TNFR2 mediates T cell-dependent hepatitis in vivo. The activation of leukocytes does not appear to be disturbed by the absence of TNFR2...
  33. ncbi Neurokinin-1 receptor antagonists CP-96,345 and L-733,060 protect mice from cytokine-mediated liver injury
    Renate Bang
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nuremberg, Erlangen, Germany
    J Pharmacol Exp Ther 305:31-9. 2003
    ..NK-1 receptor antagonists might be potent drugs for treatment of inflammatory liver disease, most likely by inhibiting SP effects...
  34. ncbi Alpha-lipoic acid preconditioning reduces ischemia-reperfusion injury of the rat liver via the PI3-kinase/Akt pathway
    Christian Muller
    Dept of Pharmacy, Center of Drug Research, Univ of Munich, Germany
    Am J Physiol Gastrointest Liver Physiol 285:G769-78. 2003
    ..This study shows for the first time that the PI3-kinase/Akt pathway plays a central protective role in IRI of the rat liver and that LA administration attenuates IRI via this pathway...
  35. ncbi Silibinin protects mice from T cell-dependent liver injury
    Jens Schumann
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nuremberg, Fahrstrasse 17, DE 91054 Erlangen, Germany
    J Hepatol 39:333-40. 2003
    ..Here, we characterized the hepatoprotective potential of silibinin as an immune-response modifier in T cell-dependent hepatitis in vivo...
  36. ncbi Atrial natriuretic peptide preconditioning protects against hepatic preservation injury by attenuating necrotic and apoptotic cell death
    Tobias Gerwig
    Department of Pharmacy, Center of Drug Research, University of Munich, Klinikum Grosshadern, Marchioninistrasse 15, D 81377 Munich, Germany
    J Hepatol 39:341-8. 2003
    ..Aim of this study was to characterize the influence of ANP preconditioning on necrotic and apoptotic cell death and on proliferation...
  37. ncbi Protective effects of ischemic preconditioning and application of lipoic acid prior to 90 min of hepatic ischemia in a rat model
    Friedrich Duenschede
    University Hospital Mainz, Department of General and Abdominal Surgery, Langenbeckstrasse 1, 55131 Mainz, Germany
    World J Gastroenterol 13:3692-8. 2007
    ..Interventions comprised different modes of ischemic preconditioning (IP) as well as pharmacologic pretreatment by alpha-lipoic acid (LA)...
  38. ncbi Metalloporphyrins inactivate caspase-3 and -8
    Signe B Blumenthal
    Department of Pharmacy, Center of Drug Research, University of Munich, Germany
    FASEB J 19:1272-9. 2005
    ..The data shown here introduce metalloporphyrins as direct inhibitors of caspase activity. This finding points to the need for careful employment of metalloporphyrins as modulators of HO-1...
  39. ncbi Non-invasive live-cell measurement of changes in macrophage NAD(P)H by two-photon microscopy
    Eleanor P W Kable
    Electron Microscope Unit, Australian Key Centre for Microscopy and Microanalysis, Madsen Building FO9, University of Sydney, NSW 2006, Sydney, Australia
    Immunol Lett 96:33-8. 2005
    ..Activators of NADPH oxidase lead to significantly decreased NAD(P)H autofluorescence. Therefore, this work shows the suitability of two-photon microscopy as a non-invasive method determining changes in phagocyte NAD(P)H upon activation...
  40. ncbi Alpha-lipoic acid as a directly binding activator of the insulin receptor: protection from hepatocyte apoptosis
    Britta Diesel
    Department of Pharmacy, Pharmaceutical Biology, Saarland University, Saarbrucken, Germany
    Biochemistry 46:2146-55. 2007
    ..Alpha-lipoic acid has cytoprotective potential which has previously been explained by its antioxidant properties. The aim of this study was to assess LA-induced-specific cytoprotective signalling pathways in hepatocytes...