Research Topics
| M KettelerSummaryAffiliation: University Hospital Country: Germany Publications
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Detail Information
Publications
Kidney failure and the gut: p-cresol and the dangers from withinM Ketteler
Department of Nephrology, University Hospital of the Rheinisch Westfälische Technische Hochschule Aachen, Aachen, Germany
Kidney Int 69:952-3. 2006..By identifying the protein-bound solute p-cresol as a risk factor for mortality in dialysis patients, Bammens and colleagues for the first time present evidence of a clinically relevant uremic toxin in relation to clinical outcome...- An update on herpes virus infections in graft recipientsMarkus Ketteler
Department of Nephrology and Clinical Immunology, University Hospital Aachen, Germany
Nephrol Dial Transplant 18:1703-6. 2003 - Calcification and cardiovascular health: new insights into an old phenomenonMarkus Ketteler
Department of Nephrology and Clinical Immunology, University Hospital Aachen, Germany
Hypertension 47:1027-34. 2006 - Do not be misguided by guidelines: the calcium x phosphate product can be a Trojan horseMarkus Ketteler
Department of Nephrology, University Hospital Aachen, Germany
Nephrol Dial Transplant 20:673-7. 2005 - "Missing" inhibitors of calcification: general aspects and implications in renal failureMarkus Ketteler
Department of Nephrology and Clinical Immunology, University Hospital Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany
Pediatr Nephrol 20:383-8. 2005.... - Association of low fetuin-A (AHSG) concentrations in serum with cardiovascular mortality in patients on dialysis: a cross-sectional studyMarkus Ketteler
Department of Nephrology and Immunology, University Hospital Aachen, Aachen, Germany
Lancet 361:827-33. 2003..We aimed to investigate the hypothesis that AHSG deficiency is directly related to uraemic vascular calcification... - Novel insights into uremic vascular calcification: role of matrix Gla protein and alpha-2-Heremans Schmid glycoprotein/fetuinMarkus Ketteler
Department of Nephrology and Clinical Immunology, University Hospital Aachen, Germany
Blood Purif 20:473-6. 2002.... - Pathogenesis of vascular calcification in dialysis patientsMarkus Ketteler
Department of Nephrology and Clinical Immunology, University Hospital Aachen, Pauwelsstrasse 30, D 52057 Aachen, Germany
Clin Exp Nephrol 9:265-70. 2005..This overview intends to summarize current knowledge of the scientific concepts involved in the pathogenesis of extraosseous calcification in ESRD... - Calcification and the usual suspect phosphate: still guilty but there are other guys behind the scenesMarkus Ketteler
Division of Nephrology, RWTH University Hospital Aachen, Germany
Nephrol Dial Transplant 21:33-5. 2006 - Nitric oxide synthase isoform expression in acute versus chronic anti-Thy 1 nephritisMarkus Ketteler
Department of Medicine II, University Hospital Aachen, Pauwelsstrasse 30, D 52057 Aachen, Germany
Kidney Int 61:826-33. 2002..We investigated whether the glomerular expression pattern of nitric oxide synthase (NOS) isoforms could explain these substrain-related differences... - Fetuin-A and extraosseous calcification in uremiaMarkus Ketteler
Department of Nephrology and Clinical Immunology, University Hospital Aachen, Germany
Curr Opin Nephrol Hypertens 14:337-42. 2005..The emerging role of fetuin-A deficiency as a risk factor in dialysis patients was documented in a cross-sectional study demonstrating a significant correlation with all-cause and cardiovascular mortality... - [Is there a correlation between C-reactive protein and calcification inhibitors with cardiovascular parameters and risk factors in hemodialysis patients?]G Schlieper
Medizinische Klinik II, Nephrologie und klinische Immunologie, Universitatsklinikum Aachen, Germany
Dtsch Med Wochenschr 132:1820-4. 2007..Functional and morphological vascular parameters are used to assess cardiovascular risk. The aim of our study was to analyse the relation between pulse wave velocity (PWV) and intima-media-thickness (IMT) with calcification inhibitors... - beta2-microglobulin-derived amyloidosis: an updateJ Floege
Division of Nephrology, University of Aachen, Aachen, Germany
Kidney Int Suppl 78:S164-71. 2001..Such factors, which have changed over the last years as part of general improvements in dialysis care, may explain why the prevalence of the amyloidosis appears to decrease... - Imaging techniques in the diagnosis of dialysis-related amyloidosisM Ketteler
Division of Nephrology, University Hospital of Aachen Technical University, Aachen, Germany
Semin Dial 14:90-3. 2001..In conclusion, scintigraphy for A beta(2)M with (111)In-labeled rh beta(2)M provides a homogeneous and safe recombinant protein source and represents a suitable detection method of beta(2)M amyloid deposits in dialysis patients... - [Prevalence and pathogenesis of aortic valve calcifications]Ralf Koos
Medizinische Klinik I, , Aachen
Herz 31:629-34. 2006..Moreover, the role calcification inhibitors in the pathogenesis of aortic valve calcification is discussed... - Sevelamer prevents uremia-enhanced atherosclerosis progression in apolipoprotein E-deficient miceOlivier Phan
INSERM Unit 507, Necker Hospital, Paris, France
Circulation 112:2875-82. 2005.... 
Association of fetuin-A with mitral annular calcification and aortic stenosis among persons with coronary heart disease: data from the Heart and Soul StudyJoachim H Ix
Division of Nephrology, Department of Medicine, Box 0532, HSE 672, University of California, San Francisco, San Francisco, CA 94143 0532, USA
Circulation 115:2533-9. 2007..Lower serum fetuin-A concentrations are associated with valvular calcification in persons with end-stage renal disease. Whether fetuin-A is associated with valvular calcification in other patient populations is unknown...- Vascular calcification and fetuin-A deficiency in chronic kidney diseaseRalf Westenfeld
Department of Nephrology and Clinical Immunology, University Hospital Aachen, Aachen, Germany
Trends Cardiovasc Med 17:124-8. 2007..The emerging role of fetuin-A deficiency as a risk factor in dialysis patients was documented in cross-sectional studies demonstrating a significant correlation with all-cause and cardiovascular mortality... - Study on the relationship of serum fetuin-A concentration with aortic stiffness in patients on dialysisMarc M H Hermans
Department of Internal Medicine and Nephrology, Academic Hospital Maastricht, PO Box 5800, 6202 AZ, Maastricht, The Netherlands
Nephrol Dial Transplant 21:1293-9. 2006..In this study, the relation between serum fetuin-A concentration and parameters of aortic stiffness was investigated in patients with end-stage renal disease... - Fetuin-A (AHSG) prevents extraosseous calcification induced by uraemia and phosphate challenge in miceRalf Westenfeld
Department of Nephrology and Clinical Immunology, University Hospital Aachen, Pauwelsstrasse 30, D 52057 Aachen, Germany
Nephrol Dial Transplant 22:1537-46. 2007..Chronic kidney disease (CKD) is associated with vascular and tissue calcification. The extent of vascular calcification has been identified as an independent risk factor of cardiovascular death in patients on haemodialysis... - Inhibitors of calcification in blood and urineGeorg Schlieper
Department of Nephrology and Clinical Immunology, University Hospital Aachen, Aachen, Germany
Semin Dial 20:113-21. 2007..This review summarizes current experimental and clinical data underlining the biological importance of these calcification inhibitors... - After several years of witchhunting, can calcium-based phosphate binding be released on probation?Markus Ketteler
Nephrol Dial Transplant 23:17-9. 2008 - Spatial inhomogeneity of common carotid artery intima-media is increased in dialysis patientsMarc M H Hermans
Department of Internal Medicine and Nephrology, Academic Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands, and Department of Nephrology and Clinical Immunology, University Hospital RWTH, Aachen, Germany
Nephrol Dial Transplant 22:1205-12. 2007..With a new ultrasound technique CCA-IMT and IMT-inhomogeneity, a novel parameter of spatial variance of the IMT, were measured and related to traditional and non-traditional risk factors... - Fetuin-A and kidney function in persons with coronary artery disease--data from the Heart and Soul StudyJoachim H Ix
Division of Nephrology, Department of Medicine, Box 0532, HSE 672, University of California, San Francisco, San Francisco, CA 94143 0532, USA
Nephrol Dial Transplant 21:2144-51. 2006..Whether fetuin-A concentrations are also lower in the setting of mild-to-moderate chronic kidney disease (CKD) is unknown... - Myocardial stiffness, cardiac remodeling, and diastolic dysfunction in calcification-prone fetuin-A-deficient miceMarc W Merx
Medical Clinic I, RWTH University Hospital, Aachen, Germany
J Am Soc Nephrol 16:3357-64. 2005.... - Mineral chaperones: a role for fetuin-A and osteopontin in the inhibition and regression of pathologic calcificationWilli Jahnen-Dechent
Department of Biomedical Engineering, Biointerface Laboratory, RWTH Aachen University Clinics, Pauwelsstrasse 30, 52074 Aachen, Germany
J Mol Med (Berl) 86:379-89. 2008..In particular, we discuss the roles of the plasma protein fetuin-A/alpha2HS-glycoprotein and the mineral-binding protein osteopontin in the prevention and possible regression of mineralization in disease... - Current management of secondary hyperparathyroidism: a multicenter observational study (COSMOS)Jorge B Cannata-Andia
Servicio de Metabolismo Oseo y Mineral, Instituto Reina Sofia de Investigacion, Hospital Universitario Central de Asturias, Oveido, Spain
J Nephrol 21:290-8. 2008..Second, to evaluate the additional value of albumin and hemoglobin levels in conjunction with bone mineral markers in the prediction of mortality and clinical events... - Undercarboxylated matrix GLA protein levels are decreased in dialysis patients and related to parameters of calcium-phosphate metabolism and aortic augmentation indexMarc M H Hermans
Department of Internal Medicine and Nephrology, Academic Hospital Maastricht, Maastricht, The Netherlands
Blood Purif 25:395-401. 2007..Vascular calcifications are related to cardiovascular mortality and morbidity in dialysis patients. Limited data exist on the role of calcification inhibitors, such as matrix-carboxyglutamic acid protein (MGP) in dialysis patients... - Angiotensin-converting enzyme inhibition but not beta-adrenergic blockade limits transforming growth factor-beta overexpression in acute normotensive anti-thy1 glomerulonephritisHarm Peters
Division of Nephrology, Charite, Campus Mitte, Humboldt University, Berlin, Germany
J Hypertens 21:771-80. 2003.... - The serum protein alpha 2-Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcificationCora Schafer
Interdisciplinary Center for Clinical Research on Biochematerials, University Clinics, Aachen, Germany
J Clin Invest 112:357-66. 2003..Taken together, our data demonstrate a critical role of Ahsg as an inhibitor of unwanted mineralization and provide a novel therapeutic concept to prevent ectopic calcification accompanying various diseases... - Vascular calcification in chronic kidney diseaseWilliam G Goodman
Division of Nephrology, UCLA Medical Center, Los Angeles, CA 90095, USA
Am J Kidney Dis 43:572-9. 2004 - Efficacy and tolerability of sevelamer carbonate in hyperphosphatemic patients who have chronic kidney disease and are not on dialysisMarkus Ketteler
Nephrologische Klinik, Klinikum Coburg gGmbH, Ketschendorfer Strasse 33, 96450 Coburg, Germany
Clin J Am Soc Nephrol 3:1125-30. 2008..This study investigated the ability of sevelamer carbonate to control serum phosphorous in hyperphosphatemic patients who had chronic kidney disease and were not on dialysis... 
The circulating inactive form of matrix Gla Protein (ucMGP) as a biomarker for cardiovascular calcificationEllen C M Cranenburg
VitaK, Maastricht University, Maastricht, The Netherlands
J Vasc Res 45:427-36. 2008..Here we report on the development of an ucMGP assay and the potential diagnostic utility of monitoring serum ucMGP levels...- Vascular calcification in patients with end-stage renal diseaseJurgen Floege
Medizinische Klinik II, Klinikum der RWTH, Pauwelsstrasse 30, D 52074 Aachen, Germany
Nephrol Dial Transplant 19:V59-66. 2004..Yet, it remains unclear whether sevelamer HCl reduces vascular calcification by preventing episodes of hypercalcaemia and/or by reducing low-density lipoprotein (LDL)-cholesterol levels... - Inducible nitric oxide synthase-derived nitric oxide promotes glomerular angiogenesis via upregulation of vascular endothelial growth factor receptorsTammo Ostendorf
Division of Nephrology and Immunology, University Hospital Aachen, Pauwelsstrasse 30, D 52074 Aachen, Germany
J Am Soc Nephrol 15:2307-19. 2004..These data identify iNOS-derived NO production as the first in vivo regulator of the glomerular VEGF system and as an important mechanism promoting glomerular healing... - Serum fetuin-A in nondialyzed patients with diabetic nephropathy: relationship with coronary artery calcificationRajnish Mehrotra
Division of Nephrology and Hypertension, Harbor UCLA Medical Center, Torrance, California 90502, USA
Kidney Int 67:1070-7. 2005..Fetuin-A is the most potent circulating inhibitor of calcium phosphorus precipitation and, possibly, an important mediator of insulin resistance... - Is fetuin-A/alpha2-Heremans-Schmid glycoprotein associated with the metabolic syndrome in patients with chronic kidney disease?Jonas Axelsson
Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
Am J Nephrol 28:669-76. 2008..We studied circulating AHSG (ELISA) and two common functional AHSG gene polymorphisms (at amino acids Thr248Met (C-T) and Thr256Ser (C-G) using Pyrosequencing) and related these to multiple components of the metabolic syndrome... - IL-10, IL-6, and TNF-alpha: central factors in the altered cytokine network of uremia--the good, the bad, and the uglyPeter Stenvinkel
Division of Renal Medicine and Baxter Novum, Department of Clinical Science, Karolinska Institutet, Karolinska University Hospital at Huddinge, Stockholm, Sweden
Kidney Int 67:1216-33. 2005.... - Role of calcification inhibitors in the pathogenesis of vascular calcification in chronic kidney disease (CKD)Sharon M Moe
Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Kidney Int 67:2295-304. 2005..This suggests protective mechanisms, or naturally occurring inhibitors, of calcification may be important... - Selective inhibition of inducible nitric oxide synthase enhances intraglomerular coagulation in chronic anti-Thy 1 nephritisRalf Westenfeld
Department of Medicine II, University Hospital Aachen, Pauwelsstrasse 30, D 52057 Aachen, Germany
Kidney Int 61:834-8. 2002..We investigated the effect of selective iNOS inhibition by l-N6-(1-iminoethyl)-lysine (L-NIL) administration on aThy 1-GN in LEW/Maa rats... - Development of lumbar bone mineral density in the late course after kidney transplantationVincent M Brandenburg
Department of Nephrology, University Hospital, Rheinisch Westfälische Technische Hochschule Aachen, Aachen, Germany
Am J Kidney Dis 40:1066-74. 2002..Rapid bone loss is a frequent finding early after kidney transplantation. Only limited data are available on the bone mineral density (BMD) in long-term kidney transplant recipients... - Unclear fever 7 weeks after renal transplantation in a 56-year-old patientAnne Guetgemann
Department of Nephrology and Clinical Immunology, University Hospital Aachen Pauwelsstrasse 30, D-52057 Aachen, Germany
Nephrol Dial Transplant 21:2325-7. 2006 - Association between human fetuin-A and the metabolic syndrome: data from the Heart and Soul StudyJoachim H Ix
Division of Nephrology, Department of Medicine, University of California, San Francisco, CA 94143 0532, USA
Circulation 113:1760-7. 2006..We evaluated the association between human serum fetuin-A and the metabolic syndrome (MetS) in a cohort of persons with coronary artery disease... - Characteristics and performance of an immunosorbent assay for human matrix Gla-proteinLeon J Schurgers
VitaK and Department of Biochemistry, Maastricht University, The Netherlands
Clin Chim Acta 351:131-8. 2005..CONCLUSIONS: The assay allows comparison of groups and may become a suitable marker for risk assessment or diagnosis in cardiovascular disease and osteoarthritis... - Lumbar bone mineral density in very long-term renal transplant recipients: impact of circulating sex hormonesVincent M Brandenburg
Department of Nephrology, University Hospital, Rheinisch Westfälische Technische Hochschule Aachen, 52057, Aachen, Germany
Osteoporos Int 16:1611-20. 2005..The lumbar BMD decreased by -0.6+/-1.9% per year. In postmenopausal long-term renal transplant recipients, low estradiol levels were associated with accelerated bone loss... - The fate of bone after renal transplantationVincent M Brandenburg
Department of Nephrology, University Hospital, Rheinisch Westfäilische Technische Hochschule, Aachen, Aachen, Germany
J Nephrol 17:190-204. 2004..However, it is yet unproven that they reduce the fracture risk. In patients with adynamic bone disease, bisphosphonate usage cannot be recommended, since this group of drugs could oversuppress bone metabolism... - Underestimated complications in thrombotic thrombocytopenic purpura--haemolytic uraemic syndromeVincent M Brandenburg
Department of Nephrology, University Hospital Aachen, Germany
Nephrol Dial Transplant 19:2142-6. 2004 - Early rapid loss followed by long-term consolidation characterizes the development of lumbar bone mineral density after kidney transplantationVincent M Brandenburg
Department of Nephrology, University Hospital, Rheinisch Westfälische Technische Hochschule RWTH Aachen, Germany
Transplantation 77:1566-71. 2004..Bone mineral density (BMD) decreases significantly early after renal transplantation. This prospective study was designed to evaluate the long-term lumbar BMD development... - Bone pain with scintigraphy suggestive of widespread metastases--do not forget phosphateVincent M Brandenburg
Division of Nephrology, University Hospital, Medical School, Aachen, Germany
Nephrol Dial Transplant 17:504-7. 2002