Winfried V Kern

Summary

Affiliation: University Hospital
Country: Germany

Publications

  1. doi request reprint Oral antibiotics for fever in low-risk neutropenic patients with cancer: a double-blind, randomized, multicenter trial comparing single daily moxifloxacin with twice daily ciprofloxacin plus amoxicillin/clavulanic acid combination therapy--EORTC infectiou
    Winfried V Kern
    Universitatsklinikum Freiburg, Freiburg, Germany
    J Clin Oncol 31:1149-56. 2013
  2. doi request reprint [Management of patients with EHEC/HUS. Lessons and perspectives from clinical infectious disease specialists]
    W V Kern
    Zentrum Infektiologie und Reisemedizin und IFB Zentrum für chronische Immundefizienz, Medizinische Universitatsklinik Freiburg, Hugstetterstr 55, 79106, Freiburg, Deutschland
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 56:87-94. 2013
  3. doi request reprint [Rational antibiotic prescribing. Challenges and successes]
    W V Kern
    Zentrum Infektiologie und Reisemedizin, Medizinische Universitatsklinik, Hugstetterstrasse 55, Freiburg, Germany
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 55:1418-26. 2012
  4. ncbi request reprint Fluoroquinolone resistance of Escherichia coli at a cancer center: epidemiologic evolution and effects of discontinuing prophylactic fluoroquinolone use in neutropenic patients with leukemia
    W V Kern
    Center for Infectious Diseases and Travel Medicine, Department of Medicine, University Hospital, Hugstetter Strasse 55, 79106 Freiburg, Germany
    Eur J Clin Microbiol Infect Dis 24:111-8. 2005
  5. ncbi request reprint [Infections after organ transplantation]
    W V Kern
    Zentrum Infektiologie und Reisemedizin, Medizinische Klinik und Poliklinik, Universitatsklinikum Freiburg
    Internist (Berl) 46:630-42. 2005
  6. doi request reprint [Nosocomial infections: MRSA und CDAD as a challenge]
    W V Kern
    Medizinische Klinik Infektiologie, Klinikum der Albert Ludwigs Universität, Hugstetter Strasse 55, 79106 Freiburg
    Internist (Berl) 50:691-703; quiz 704-5. 2009
  7. ncbi request reprint Effect of 1-(1-naphthylmethyl)-piperazine, a novel putative efflux pump inhibitor, on antimicrobial drug susceptibility in clinical isolates of Escherichia coli
    Winfried V Kern
    Center for Infectious Diseases and Travel Medicine, Department of Medicine, University Hospital, Freiburg, Germany
    J Antimicrob Chemother 57:339-43. 2006
  8. ncbi request reprint Daptomycin: first in a new class of antibiotics for complicated skin and soft-tissue infections
    W V Kern
    Department of Medicine and Center for Infectious Diseases and Travel Medicine, University Hospital Freiburg, Germany
    Int J Clin Pract 60:370-8. 2006
  9. ncbi request reprint Regional variation in outpatient antibiotic prescribing in Germany
    W V Kern
    Center for Infectious Diseases and Travel Medicine, University Hospital, Hugstetter Str 55, 79106, Freiburg, Germany
    Infection 34:269-73. 2006
  10. ncbi request reprint [Infectiology -- new scenarios, ever increasing tasks]
    W V Kern
    Zentrum Infektiologie und Reisemedizin, Medizinische Klinik und Poliklinik, Universitatsklinikum, Freiburg
    Dtsch Med Wochenschr 130:1559-62. 2005

Detail Information

Publications73

  1. doi request reprint Oral antibiotics for fever in low-risk neutropenic patients with cancer: a double-blind, randomized, multicenter trial comparing single daily moxifloxacin with twice daily ciprofloxacin plus amoxicillin/clavulanic acid combination therapy--EORTC infectiou
    Winfried V Kern
    Universitatsklinikum Freiburg, Freiburg, Germany
    J Clin Oncol 31:1149-56. 2013
    ..This double-blind, multicenter trial compared the efficacy and safety of a single daily oral dose of moxifloxacin with oral combination therapy in low-risk febrile neutropenic patients with cancer...
  2. doi request reprint [Management of patients with EHEC/HUS. Lessons and perspectives from clinical infectious disease specialists]
    W V Kern
    Zentrum Infektiologie und Reisemedizin und IFB Zentrum für chronische Immundefizienz, Medizinische Universitatsklinik Freiburg, Hugstetterstr 55, 79106, Freiburg, Deutschland
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 56:87-94. 2013
    ..We expect that proceeding in this way will also have a major impact on proper planning, professional design, and adequate analysis of clinical studies and endpoints appropriate for the outbreak situation...
  3. doi request reprint [Rational antibiotic prescribing. Challenges and successes]
    W V Kern
    Zentrum Infektiologie und Reisemedizin, Medizinische Universitatsklinik, Hugstetterstrasse 55, Freiburg, Germany
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 55:1418-26. 2012
    ....
  4. ncbi request reprint Fluoroquinolone resistance of Escherichia coli at a cancer center: epidemiologic evolution and effects of discontinuing prophylactic fluoroquinolone use in neutropenic patients with leukemia
    W V Kern
    Center for Infectious Diseases and Travel Medicine, Department of Medicine, University Hospital, Hugstetter Strasse 55, 79106 Freiburg, Germany
    Eur J Clin Microbiol Infect Dis 24:111-8. 2005
    ..Relative rates of resistance thus were a poor indicator of the potential clinical benefits associated with fluoroquinolone prophylaxis in cancer patients...
  5. ncbi request reprint [Infections after organ transplantation]
    W V Kern
    Zentrum Infektiologie und Reisemedizin, Medizinische Klinik und Poliklinik, Universitatsklinikum Freiburg
    Internist (Berl) 46:630-42. 2005
    ..Physicians caring for patients after organ transplantation need to early consider in the differential diagnosis rare pathogens which are often overlooked with standard diagnostic procedures...
  6. doi request reprint [Nosocomial infections: MRSA und CDAD as a challenge]
    W V Kern
    Medizinische Klinik Infektiologie, Klinikum der Albert Ludwigs Universität, Hugstetter Strasse 55, 79106 Freiburg
    Internist (Berl) 50:691-703; quiz 704-5. 2009
    ..Close collaboration between hospitals, nursing homes and primary care institutions will be critical for better control of MRSA and CDAD...
  7. ncbi request reprint Effect of 1-(1-naphthylmethyl)-piperazine, a novel putative efflux pump inhibitor, on antimicrobial drug susceptibility in clinical isolates of Escherichia coli
    Winfried V Kern
    Center for Infectious Diseases and Travel Medicine, Department of Medicine, University Hospital, Freiburg, Germany
    J Antimicrob Chemother 57:339-43. 2006
    ..coli...
  8. ncbi request reprint Daptomycin: first in a new class of antibiotics for complicated skin and soft-tissue infections
    W V Kern
    Department of Medicine and Center for Infectious Diseases and Travel Medicine, University Hospital Freiburg, Germany
    Int J Clin Pract 60:370-8. 2006
    ..The unique mode of action of daptomycin is described alongside studies demonstrating its potential in the treatment of cSSTIs and other infections caused by Gram-positive bacteria...
  9. ncbi request reprint Regional variation in outpatient antibiotic prescribing in Germany
    W V Kern
    Center for Infectious Diseases and Travel Medicine, University Hospital, Hugstetter Str 55, 79106, Freiburg, Germany
    Infection 34:269-73. 2006
    ..We assessed regional variation in outpatient antibiotic use within Germany both for overall use as well as for specific antibiotic drug classes...
  10. ncbi request reprint [Infectiology -- new scenarios, ever increasing tasks]
    W V Kern
    Zentrum Infektiologie und Reisemedizin, Medizinische Klinik und Poliklinik, Universitatsklinikum, Freiburg
    Dtsch Med Wochenschr 130:1559-62. 2005
  11. ncbi request reprint Hospital antibiotic management in Germany--results of the ABS maturity survey of the ABS International group
    Winfried V Kern
    Medizinische Universitatsklinik, Zentrum Infektiologie und Reisemedizin, Freiburg, Germany
    Wien Klin Wochenschr 120:294-8. 2008
    ..The ABS International group conducted a survey to estimate the prevalence and characteristics of country-specific hospital antibiotic management programs and program components. This paper summarizes the results for Germany...
  12. doi request reprint Management of Staphylococcus aureus bacteremia and endocarditis: progresses and challenges
    Winfried V Kern
    Center for Infectious Diseases and Travel Medicine, and IFB Center for Chronic Immunodeficiency, University Hospital, and Department of Medicine, Albert Ludwigs University, Freiburg, Germany
    Curr Opin Infect Dis 23:346-58. 2010
    ..The purpose of this review was to analyze most recent data relevant to the clinical management of S. aureus bacteremia (SAB) and endocarditis...
  13. doi request reprint [Bacteraemia and sepsis]
    W V Kern
    Zentrum Infektiologie und Reisemedizin, Medizinische Universitätsklinik 79106 Freiburg
    Dtsch Med Wochenschr 136:182-5. 2011
    ..The incidence of MRSA bacteraemia in Germany can now be estimated better as it has become a notifiable infection...
  14. ncbi request reprint Antibiotic use in German university hospitals 1998-2000 (Project INTERUNI-II)
    Katja de With
    Center for Infectious Diseases and Travel Medicine, University Hospital, Hugstetter Strass 55, D 79106 Freiburg, Germany
    Int J Antimicrob Agents 24:213-8. 2004
    ..The established database allows detailed analysis in antibacterial drug use and can be linked to bacterial resistance surveillance databases...
  15. doi request reprint Susceptibility of clinical Staphylococcus aureus isolates to innate defense antimicrobial peptides
    Siegbert Rieg
    Center for Infectious Diseases and Travel Medicine, Department of Medicine, University Hospital, Hugstetter Strasse 55, D 79106 Freiburg, Germany
    Microbes Infect 13:761-5. 2011
    ..These data do not support a role for differential AMP susceptibility in vitro as a major determinant of S. aureus invasive infection...
  16. ncbi request reprint Altered spectrum of multidrug resistance associated with a single point mutation in the Escherichia coli RND-type MDR efflux pump YhiV (MdtF)
    Jürgen A Bohnert
    Center for Infectious Diseases and Travel Medicine, University Hospital, Freiburg, Germany
    J Antimicrob Chemother 59:1216-22. 2007
    ..We characterized two mutants of E. coli E12 (DeltaacrB DeltaacrF) overexpressing yhiV that showed surprising differences in their spectrum of multidrug resistance (MDR)...
  17. pmc Microarray-based genotyping and clinical outcomes of Staphylococcus aureus bloodstream infection: an exploratory study
    Siegbert Rieg
    Department of Medicine, Center for Infectious Diseases and Travel Medicine and IFB Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany
    PLoS ONE 8:e71259. 2013
    ..aureus can only partially explain clinical features and outcomes of S. aureus bacteremia. Genotype-phenotype association studies need to include adjustments for host factors like age, comorbidity and community-acquisition. ..
  18. ncbi request reprint Fluoroquinolone consumption and resistance in haematology-oncology patients: ecological analysis in two university hospitals 1999-2002
    Winfried V Kern
    Center for Infectious Diseases and Travel Medicine, Department of Medicine, Institute of Environmental Medicine and Hospital Epidemiology, University Hospital, Hugstetter Strasse 55, D 79106 Freiburg, Germany
    J Antimicrob Chemother 55:57-60. 2005
    ..To compare rates of in vitro fluoroquinolone resistance of bacterial isolates obtained from inpatients of two haematology-oncology services with high and low fluoroquinolone consumption...
  19. ncbi request reprint Multidrug efflux inhibition in Acinetobacter baumannii: comparison between 1-(1-naphthylmethyl)-piperazine and phenyl-arginine-beta-naphthylamide
    Stefanie Pannek
    Center for Infectious Diseases and Travel Medicine, University Hospital, Freiburg, Germany
    J Antimicrob Chemother 57:970-4. 2006
    ..1-(1-Naphthylmethyl)-piperazine (NMP) has been shown to reverse multidrug resistance (MDR) in Escherichia coli overexpressing RND-type efflux pumps but there are no data on its activity in non-fermenters like Acinetobacter...
  20. ncbi request reprint Effect of 1-(1-naphthylmethyl)-piperazine, a novel putative efflux pump inhibitor, on antimicrobial drug susceptibility in clinical isolates of Enterobacteriaceae other than Escherichia coli
    Anja Schumacher
    Center for Infectious Diseases and Travel Medicine, Department of Medicine, University Hospital, Freiburg, Germany
    J Antimicrob Chemother 57:344-8. 2006
    ..1-(1-Naphthylmethyl)-piperazine (NMP) has been shown to reverse multidrug resistance (MDR) in Escherichia coli overexpressing RND type efflux pumps, but there is no data on its activity in Enterobacteriaceae other than E. coli...
  21. pmc Site-directed mutagenesis reveals putative substrate binding residues in the Escherichia coli RND efflux pump AcrB
    Jürgen A Bohnert
    Center for Infectious Diseases and Travel Medicine, University Hospital, Department of Medicine, Albert Ludwigs University, Freiburg, Germany
    J Bacteriol 190:8225-9. 2008
    ....
  22. doi request reprint Resistance against antimicrobial peptides is independent of Escherichia coli AcrAB, Pseudomonas aeruginosa MexAB and Staphylococcus aureus NorA efflux pumps
    Siegbert Rieg
    Center for Infectious Diseases and Travel Medicine, Department of Medicine, University Hospital, Freiburg, Germany
    Int J Antimicrob Agents 33:174-6. 2009
    ..These findings do not support a critical role of MDR efflux pumps in the tested pathogens as a strategy to increase virulence by circumventing the antimicrobial action of innate defence AMPs...
  23. pmc Hospital use of systemic antifungal drugs
    Katja de With
    Center for Infectious Diseases and Travel Medicine, University Hospital, D 79106 Freiburg, Germany
    BMC Clin Pharmacol 5:1. 2005
    ..Given the concerns about the potential emergence of antifungal drug resistance, data on drug use density, however, may be valuable and are needed for analyses of the relationship between drug use and antifungal resistance...
  24. ncbi request reprint Efflux inhibition by selective serotonin reuptake inhibitors in Escherichia coli
    Jürgen A Bohnert
    Center for Infectious Diseases and Travel Medicine, University Hospital, and Department of Medicine, Albert Ludwigs University, Freiburg, Germany
    J Antimicrob Chemother 66:2057-60. 2011
    ....
  25. pmc Differential activity of innate defense antimicrobial peptides against Nocardia species
    Siegbert Rieg
    Center for Infectious Diseases and Travel Medicine, University Medical Center, Hugstetter Strasse 55, 79106 Freiburg, Germany
    BMC Microbiol 10:61. 2010
    ....
  26. ncbi request reprint Mortality of S. aureus bacteremia and infectious diseases specialist consultation--a study of 521 patients in Germany
    Siegbert Rieg
    Department of Medicine, Center for Infectious Diseases and Travel Medicine, University Medical Center Freiburg, Hugstetter Str 55, 79106 Freiburg, Germany
    J Infect 59:232-9. 2009
    ..To evaluate the relationship between mortality of bloodstream infection due to Staphylococcus aureus and infectious diseases specialist consultation and other factors potentially associated with outcomes...
  27. ncbi request reprint Intracellular accumulation of linezolid in Escherichia coli, Citrobacter freundii and Enterobacter aerogenes: role of enhanced efflux pump activity and inactivation
    Anja Schumacher
    Center for Infectious Diseases and Travel Medicine, University Hospital Hugstetter Strasse 55, Freiburg, Germany
    J Antimicrob Chemother 59:1261-4. 2007
    ..We hypothesized that the poor activity of linezolid in Gram-negative bacteria is in part caused by relatively low intracellular concentration due to efflux...
  28. ncbi request reprint [Antibiotic Use at German University Hospitals (Project INTERUNI-II). Results for Medical Intensive Care, Hematology-Oncology, and Other Medical Service Areas]
    Katja de With
    Klinikum der Albert Ludwigs Universität, Freiburg
    Med Klin (Munich) 99:347-54. 2004
    ..Apart from economic and market research studies, estimates of antibiotic consumption in German hospitals, however, are not available...
  29. pmc Determination of real-time efflux phenotypes in Escherichia coli AcrB binding pocket phenylalanine mutants using a 1,2'-dinaphthylamine efflux assay
    Jürgen A Bohnert
    Department of Medicine, Center for Infectious Diseases and Travel Medicine, Albert Ludwigs University, University Hospital, Freiburg, Germany
    PLoS ONE 6:e21196. 2011
    ..This is the first study to demonstrate the importance of single phenylalanine residues within the AcrB binding pocket for real-time substrate transport...
  30. ncbi request reprint Risk assessment and treatment of low-risk patients with febrile neutropenia
    Winfried V Kern
    Department of Medicine, Albert Ludwigs University of Freiburg, Center for Infectious Diseases and Travel Medicine, University Hospital, Freiburg, Germany
    Clin Infect Dis 42:533-40. 2006
    ....
  31. pmc Selected arylpiperazines are capable of reversing multidrug resistance in Escherichia coli overexpressing RND efflux pumps
    Jürgen A Bohnert
    Center for Infectious Diseases and Travel Medicine, Department of Medicine, University Hospital, Freiburg, Germany
    Antimicrob Agents Chemother 49:849-52. 2005
    ....
  32. pmc Feasibility and impact of an intensified antibiotic stewardship programme targeting cephalosporin and fluoroquinolone use in a tertiary care university medical center
    Johannes P Borde
    Department of Medicine, Abteilung Infektiologie, Universitatsklinikum Freiburg, Hugstetter Straße 55, D 79106 Freiburg i, BR, Germany
    BMC Infect Dis 14:201. 2014
    ..We implemented an intensified antibiotic stewardship (ABS) programme in the medical service of a university hospital center aiming at a reduction by at least 30% in the use of these two drug classes...
  33. doi request reprint Expression of innate defense antimicrobial peptides in hidradenitis suppurativa
    Silke C Hofmann
    Department of Dermatology, University Freiburg Medical Center, Freiburg, Germany
    J Am Acad Dermatol 66:966-74. 2012
    ..Hidradenitis suppurativa (HS) is a chronic inflammatory disorder of apocrine gland-bearing skin. It is associated with alterations in innate immunity and frequent bacterial infections...
  34. ncbi request reprint Moxifloxacin prophylaxis in neutropenic patients
    H von Baum
    Department of Medical Microbiology and Hygiene, University Hospital, Ulm, Germany
    J Antimicrob Chemother 58:891-4. 2006
    ..Among the fluoroquinolones moxifloxacin currently provides one of the broadest spectra of antibacterial activity and may be suitable for prophylaxis during neutropenia...
  35. ncbi request reprint Breakthrough invasive infection due to Debaryomyces hansenii (teleomorph Candida famata) and Scopulariopsis brevicaulis in a stem cell transplant patient receiving liposomal amphotericin B and caspofungin for suspected aspergillosis
    D Wagner
    Center for Infectious Diseases and Travel Medicine, University Hospital, Hugstetter Str 55, 79106 Freiburg, Germany
    Infection 33:397-400. 2005
    ..Shortly before death, Scopulariopsis brevicaulis was cultured from bronchial secretions, and positive blood cultures demonstrated persistent candidemia due to Debaryomyces hansenii, teleomorph of Candida famata...
  36. doi request reprint Outcomes of invasive infection due to vancomycin-resistant Enterococcus faecium during a recent outbreak
    C Theilacker
    Center for Infectious Diseases and Travel Medicine, Dept of Medicine, University Hospital, Freiburg, Germany
    Infection 37:540-3. 2009
    ..Most of these studies have been conducted in US hospitals prior to the advent of newer VREF-active antimicrobials, and the reported poor outcomes have been explained by the limited choices for effective antimicrobial therapy...
  37. ncbi request reprint Update on glycopeptide use in german university hospitals
    W V Kern
    Division of Infectious Diseases, Dept of Medicine, Freiburg University Hospital, Hugstetter Strasse 55, D 79106 Freiburg, Germany
    Infection 32:157-62. 2004
    ..5 defined daily doses (DDD)/100 patient days in the subsequent period. In the present study, more recent data on comparative glycopeptide use in German university hospitals were analyzed...
  38. ncbi request reprint [Vancomycin-resistant enterococcus]
    J Huebner
    Zentrum Infektiologie und Reisemedizin, Medizinische Universitätsklinik und Poliklinik, Universitatsklinikum Freiburg, Freiburg
    Dtsch Med Wochenschr 130:2463-8. 2005
  39. ncbi request reprint Mycobacterium genavense specific mesenteritic syndrome in HIV-infected patients: a new entity of retractile mesenteritis?
    Johannes P Borde
    aOrtenauklinikum Offenburg Gengenbach, Klinik fur Gastroenterologie, Hepatologie und Infektiologie, Ebertplatz, Offenburg bDepartment of Medicine, Albert Ludwigs University Center for Infectious Diseases and Travel Medicine, and IFB Center for Chronic Immunodeficiency, University Hospital, Hugstetterstrasse, Freiburg i Br cOrtenauklinikum Achern, Medizinische Klinik Infektiologie, Josef Wurzler Straße, Achern, Germany
    AIDS 27:2819-22. 2013
    ....
  40. doi request reprint Fatal hemophagocytic syndrome in a patient with a previously well-controlled asymptomatic HIV infection after EBV reactivation
    Jan Thoden
    Centre of Chronic Immunodeficiency, University Hospital Freiburg, Hugstetter Strasse 55, 79106 Freiburg, Germany
    J Infect 64:110-2. 2012
    ..In HIV infection, HLH may be the first HIV manifestation, often triggered by an opportunistic infection or immune reconstitution syndrome, but it is uncommon in the state of a well-controlled or aviremic HIV infection...
  41. pmc Tick-borne lymphadenopathy (TIBOLA) acquired in Southwestern Germany
    Siegbert Rieg
    Center for Infectious Diseases and Travel Medicine, University Hospital Freiburg, Hugstetter Strasse, Germany
    BMC Infect Dis 11:167. 2011
    ..Tick-borne lymphadenopathy (TIBOLA) was first described in 1997 in a patient in France. The causative agent, Rickettsia slovaca, is transmitted by Dermacentor ticks...
  42. pmc Diagnostic value of reverse transcription-PCR for detection of cytomegalovirus pp67 in samples from solid-organ transplant recipients
    Ursula Meyer-Koenig
    Department of Virology, Institute for Medical Microbiology, University Hospital Freiburg, Hermann Herder Str 11, D 79104 Freiburg, Germany
    J Clin Microbiol 44:3394-6. 2006
    ..Results were compared with those of pp65 antigen testing and quantitative DNA-PCR. Due to a low clinical sensitivity, the pp67 RT-PCR was not able to replace these assays...
  43. doi request reprint [MRSA and other multi-resistant pathogens: an ever increasing problem even in ambulant medicine]
    M Dettenkofer
    Institut fur Umweltmedizin und Krankenhaushygiene, Universitatsklinikum Freiburg, Breisacherstr 115b, 79106 Freiburg
    Dtsch Med Wochenschr 133:370-1. 2008
  44. ncbi request reprint Antibiotic use in non-university regional acute care general hospitals in southwestern Germany, 2001-2002
    W V Kern
    Center for Infectious Diseases and Travel Medicine, Dept of Medicine, University Hospital, Hugstetter Str 55, 79106 Freiburg, Germany
    Infection 33:333-9. 2005
    ..In the present study, we collected data from 40 non-university regional general hospitals located in the southwestern part of the country, and analyzed use density in the medical and surgical services of these hospitals...
  45. ncbi request reprint Antibiotic use in Germany and European comparison
    K De With
    Medizinische Klinik und Poliklinik, Klinikum der Albert Ludwigs Universität, Freiburg
    Dtsch Med Wochenschr 129:1987-92. 2004
    ..However, only rough estimates of hospital antibiotic use are available for Germany as well as most other EU countries due to data usually derived from non-representative hospital sampling...
  46. ncbi request reprint Glycopeptide use at four university hospitals in southern Germany
    W V Kern
    Division of Infectious Diseases, Dept of Medicine II, University Hospital, Hugstetter Str 55, D 79106 Freiburg, Germany
    Infection 30:262-6. 2002
    ..Excessive use of glycopeptide antibiotics may enhance the risk of glycopeptide resistance among enterococci and staphylococi, but there is little data on the use of these antibiotics in German hospitals...
  47. doi request reprint Comparison of defined versus recommended versus prescribed daily doses for measuring hospital antibiotic consumption
    K De With
    Department of Medicine, Center for Infectious Diseases and Travel Medicine, University Hospital, Hugstetter Strasse 55, Freiburg, Germany
    Infection 37:349-52. 2009
    ..Previous studies have found discrepancies between DDDs, daily doses as recommended in practice guidelines (recommended daily doses, RDDs), and truly prescribed daily doses (PDDs). Very few studies have quantified these discrepancies...
  48. pmc CXCL13 may improve diagnosis in early neuroborreliosis with atypical laboratory findings
    Johannes P Borde
    Universitatsklinik Freiburg, Medizinische Klinik II Sektion Klinische Infektiologie, Hugstetter Strasse 55, Freiburg, Germany
    BMC Infect Dis 12:344. 2012
    ..Recently published data indicate that CXCL13 seems to be a promising diagnostic tool for early stage LNB. In addition, CXCL13 might be suitable for treatment monitoring...
  49. pmc Pimozide Inhibits the AcrAB-TolC Efflux Pump in Escherichia coli
    Jürgen A Bohnert
    Center for Infectious Diseases and Travel Medicine, University Hospital, and Department of Medicine, Albert Ludwigs University, Freiburg, Germany
    Open Microbiol J 7:83-6. 2013
    ..In line with previous reports we suggest that the capability of EPIs to restore the susceptibility to antimicrobial agents can be highly substrate-specific due to different substrate binding sites...
  50. ncbi request reprint Risk assessment and risk-based therapeutic strategies in febrile neutropenia
    W V Kern
    Department of Medicine, University Hospital and Medical Center, Ulm, Germany
    Curr Opin Infect Dis 14:415-22. 2001
    ....
  51. ncbi request reprint Prediction of gram-negative bacteremia in patients with cancer and febrile neutropenia by means of interleukin-8 levels in serum: targeting empirical monotherapy versus combination therapy
    W V Kern
    Department of Medicine, Section of Infectious Diseases and Clinical Immunology, University Hospital and Medical Center, D 89070 Ulm, Germany
    Clin Infect Dis 32:832-5. 2001
    ..1/122; P< .01). Serum IL-8 levels at the onset of fever define a low-risk subgroup of patients who can safely be treated with monotherapy...
  52. pmc Enhanced expression of the multidrug efflux pumps AcrAB and AcrEF associated with insertion element transposition in Escherichia coli mutants Selected with a fluoroquinolone
    A S Jellen-Ritter
    Section of Infectious Diseases and Clinical Immunology, Department of Medicine, University Hospital and Medical Center, D 89070 Ulm, Germany
    Antimicrob Agents Chemother 45:1467-72. 2001
    ..These observations confirm the importance of efflux-associated nontarget gene mutations and indicate that transposition of genetic elements may have a role in the development of fluoroquinolone resistance in E. coli...
  53. ncbi request reprint Is there significant regional variation in hospital antibiotic consumption in Germany?
    K De With
    Center for Infectious Diseases and Travel Medicine, University Hospital, Hugstetter Str 55, 79106, Freiburg, Germany
    Infection 34:274-7. 2006
    ..Whether similar regional variation exists in hospital antibiotic consumption is not known. We investigated this issue using a convenience sample of 145 hospitals providing data for the year 2003...
  54. ncbi request reprint Host cell responses induced by hepatitis C virus binding
    Xinhua Fang
    Department of Medicine II, University of Freiburg, Freiburg, Germany
    Hepatology 43:1326-36. 2006
    ..Reprogramming of cellular gene expression induced by HCV-cell surface interaction may be part of the viral strategy to condition viral entry and replication and escape from innate host cell responses...
  55. pmc Human metapneumovirus infection in a hematopoietic stem cell transplant recipient with relapsed multiple myeloma and rapidly progressing lung cancer
    B Huck
    Department of Virology, Institute for Medical Microbiology and Hygiene, University Hospital Freiburg, Freiburg, Germany
    J Clin Microbiol 44:2300-3. 2006
    ..The isolate was phylogenetically and biologically characterized and compared to HMPV prototypes and recent pediatric isolates. Remarkably, it belonged to the novel genomic subgroup A2b...
  56. ncbi request reprint Antibiotic use in two cohorts of German intensive care units
    K De With
    Centre for Infectious Diseases and Travel Medicine, Department of Medicine, University Hospital, Freiburg, Germany
    J Hosp Infect 64:231-7. 2006
    ..In conclusion, in order to compare the use of antibiotics between ICU cohorts and to assess trends over time, data adjustment is required for hospital affiliation and size...
  57. doi request reprint [Prevention of infections and thromboses after splenectomy or because of functional loss of the spleen]
    M Engelhardt
    gleichberechtigte Erstautoren, Medizinische Universitatsklinik, Innere Medizin I Hämatologie und Onkologie, Freiburg
    Dtsch Med Wochenschr 134:897-902. 2009
    ..Each patient should carry at all times a letter or card documenting the splenectomy. With these measures and precautions, the PSS-risk can be significantly reduced or at best be completely avoided...
  58. ncbi request reprint Trends in antibiotic use at a university hospital: defined or prescribed daily doses? Patient days or admissions as denominator?
    K De With
    Center for Infectious Diseases and Travel Medicine, University Hospital, Hugstetter Str 55, 79106 Freiburg, Germany
    Infection 34:91-4. 2006
    ....
  59. ncbi request reprint Perforation of a Dacron vascular endoprosthesis into the duodenum
    H Schwacha
    Department of Medicine, University Hospital, Freiburg, Germany
    Endoscopy 38:E51. 2006
  60. ncbi request reprint Impact of fluoroquinolone prophylaxis on reduced infection-related mortality among patients with neutropenia and hematologic malignancies
    Stefan Reuter
    Section of Infectious Diseases and Clinical Immunology, Department of Internal Medicine III, University Hospital of Ulm, Germany
    Clin Infect Dis 40:1087-93. 2005
    ..Bacterial antimicrobial resistance is likely to cause a progressive lack of efficacy of fluoroquinolones, but no convincing evidence from clinicoepidemiologic observations has proved this hypothesis...
  61. ncbi request reprint Antibiotics in trauma and orthopedic surgery -- a primer of evidence-based recommendations
    Martin Jaeger
    Department Orthopädie und Traumatologie, Medizinische Fakultat, Universität Freiburg i Br, Germany
    Injury 37:S74-80. 2006
    ....
  62. doi request reprint Thioridazine and chlorpromazine inhibition of ethidium bromide efflux in Mycobacterium avium and Mycobacterium smegmatis
    Liliana Rodrigues
    Unit of Mycobacteriology, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira 96, 1349 008 Lisboa, Portugal
    J Antimicrob Chemother 61:1076-82. 2008
    ..We have characterized the efflux pump activity of M. avium wild-type strain through an automated fluorometric method and correlated it with intrinsic resistance to antibiotics...
  63. ncbi request reprint Antibiotic prophylaxis in neutropenic patients: new evidence, practical decisions
    Leonard Leibovici
    Department of Medicine E, Beilinson Campus, Rabin Medical Center, Petah Tiqva, Israel
    Cancer 107:1743-51. 2006
    ..Excessive local levels of resistance to fluoroquinolones or high local incidence of infections caused by Clostridium difficile and related to fluoroquinolones should prompt a reconsideration of this policy...
  64. ncbi request reprint Comment on: hospital consumption of antibiotics in 15 European countries: results of the ESAC Retrospective Data Collection (1997-2002)
    Winfried V Kern
    J Antimicrob Chemother 58:900-1; author reply 901-2. 2006
  65. ncbi request reprint Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis
    Raoul Herbrecht
    Département d Hématologie et d Oncologie, Hopital de Hautepierre, Strasbourg, France
    N Engl J Med 347:408-15. 2002
    ..Voriconazole is a broad-spectrum triazole that is active against aspergillus species. We conducted a randomized trial to compare voriconazole with amphotericin B for primary therapy of invasive aspergillosis...
  66. ncbi request reprint Expanded spectrum of Nocardia species causing clinical nocardiosis detected by molecular methods
    Nele Wellinghausen
    Department of Medical Microbiology and Hygiene, University of Ulm, Germany
    Int J Med Microbiol 292:277-82. 2002
    ..e., N. paucivorans, N. abscessus and N. veterana). We provide data on the epidemiology, clinical significance and antimicrobial susceptibility of these newly described Nocardia species...
  67. ncbi request reprint Sepsis in neutropenia--guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO)
    Xaver Schiel
    Department of Internal Medicine III, University of Munich, Hospital Grosshadern, Marchioninistrasse 15, 81377, Munchen, Germany
    Ann Hematol 82:S158-66. 2003
    ..This paper focuses on pathophysiology, diagnosis and treatment of sepsis. Evidence based medicine (EBM) criteria are used to grade treatment recommendations [50]...
  68. ncbi request reprint Diagnosis and treatment of documented infections in neutropenic patients--recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO)
    Dieter Buchheidt
    III Medizinische Klinik, Universitatsklinikum Mannheim, Ruprecht Karls Universitat Heidelberg, Wiesbadener Strasse 7 11, 68305, Mannheim, Germany
    Ann Hematol 82:S127-32. 2003
    ..The response rate is significantly lower in documented infections than in fever of unknown origin (FUO). Evidence-based recommendations for diagnosis and treatment procedures are presented, reflecting study results and expert opinions...
  69. ncbi request reprint Chronic granulomatous lung infection caused by the dimorphic fungus Emmonsia sp
    Nele Wellinghausen
    Department of Medical Microbiology and Hygiene, University of Ulm, Ulm, Germany
    Int J Med Microbiol 293:441-5. 2003
    ..The patient showed some improvement under itraconazole treatment. This is the first description of a human infection with Emmonsia sp. in Germany...
  70. doi request reprint Demonstration of intrinsic efflux activity of Escherichia coli K-12 AG100 by an automated ethidium bromide method
    Miguel Viveiros
    Unit of Mycobacteriology, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira 96, Lisbon, Portugal
    Int J Antimicrob Agents 31:458-62. 2008
    ..The method can be used for screening compound libraries for efflux inhibiting capacity...
  71. ncbi request reprint Antibiotic efflux pumps in Gram-negative bacteria: the inhibitor response strategy
    Abdallah Mahamoud
    UMR MD 1, Facultes de Medecine et de Pharmacie, Universite de la Mediterranee, 27 Boulevard Jean Moulin, F 13385 Marseille cedex 05, France
    J Antimicrob Chemother 59:1223-9. 2007
    ....
  72. ncbi request reprint Economic evaluation of voriconazole versus conventional amphotericin B in the treatment of invasive aspergillosis in Germany
    Jeroen P Jansen
    Mapi Values, Houten, The Netherlands
    Value Health 9:12-23. 2006
    ..To assess the costs and cost-effectiveness of voriconazole in comparison to conventional amphotericin B (CAB) for the treatment of invasive aspergillosis in Germany...
  73. ncbi request reprint A fatal case of necrotizing sinusitis due to toxigenic Corynebacterium ulcerans
    Nele Wellinghausen
    Department of Medical Microbiology and Hygiene, University of Ulm, Germany
    Int J Med Microbiol 292:59-63. 2002
    ..Identification of the causative agent, pathophysiological aspects and risk factors of this unusal infection are discussed...