M Kellner

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. ncbi request reprint Intravenous C-type natriuretic peptide augments behavioral and endocrine effects of cholecystokinin tetrapeptide in healthy men
    M Kellner
    University Hospital Hamburg Eppendorf, Department of Psychiatry and Psychotherapy, Martinistrasse 52, 20246 Hamburg, Germany
    J Psychiatr Res 36:1-6. 2002
  2. pmc Experimental panic provocation in healthy man-a translational role in anti-panic drug development?
    Michael Kellner
    University Hospital Hamburg Eppendorf, Dept of Psychiatry and Psychotherapy, Anxiety Spectrum Disorders Unit, Hamburg, Germany
    Dialogues Clin Neurosci 13:485-93. 2011
  3. ncbi request reprint Overnight metyrapone and combined dexamethasone/metyrapone tests in post-traumatic stress disorder: preliminary findings
    Michael Kellner
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Eur Neuropsychopharmacol 14:337-9. 2004
  4. ncbi request reprint Metyrapone tests in patients with panic disorder
    Michael Kellner
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Biol Psychiatry 56:898-900. 2004
  5. ncbi request reprint Effects of a metabotropic glutamate(2/3) receptor agonist (LY544344/LY354740) on panic anxiety induced by cholecystokinin tetrapeptide in healthy humans: preliminary results
    Michael Kellner
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Psychopharmacology (Berl) 179:310-5. 2005
  6. doi request reprint Mineralocorticoid receptors in brain, in health and disease: possibilities for new pharmacotherapy
    Michael Kellner
    University Hospital Hamburg Eppendorf, Department of Psychiatry and Psychotherapy, Martinistrasse 52, D 20246 Hamburg, Germany
    Eur J Pharmacol 583:372-8. 2008
  7. doi request reprint The selective serotonin re-uptake inhibitor escitalopram modulates the panic response to cholecystokinin tetrapeptide in healthy men depending on 5-HTTLPR genotype
    Michael Kellner
    University Hospital Hamburg Eppendorf, Department of Psychiatry, Martinistrasse 52, D 20246 Hamburg, Germany
    J Psychiatr Res 43:642-8. 2009
  8. ncbi request reprint Trait dissociation affects the behavioral response to cholecystokinin tetrapeptide in healthy man
    Michael Kellner
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Martinistrasse 52, D 20246, Hamburg, Germany
    Psychiatry Res 111:93-6. 2002
  9. doi request reprint No effect of six weeks of treatment with escitalopram on mood in healthy volunteers--irrespective of genotype for the promoter of the serotonin transporter
    Michael Kellner
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Psychiatry Res 161:339-43. 2008
  10. doi request reprint Increased DHEA and DHEA-S plasma levels in patients with post-traumatic stress disorder and a history of childhood abuse
    Michael Kellner
    University Hospital Hamburg Eppendorf, Department of Psychiatry and Psychotherapy, Martinistrasse 52, D 20246 Hamburg, Germany
    J Psychiatr Res 44:215-9. 2010

Detail Information

Publications34

  1. ncbi request reprint Intravenous C-type natriuretic peptide augments behavioral and endocrine effects of cholecystokinin tetrapeptide in healthy men
    M Kellner
    University Hospital Hamburg Eppendorf, Department of Psychiatry and Psychotherapy, Martinistrasse 52, 20246 Hamburg, Germany
    J Psychiatr Res 36:1-6. 2002
    ..However, no effect of CNP was seen upon panic symptoms. Our preliminary data support a role of type-B natriuretic peptide receptors in anxiety modulation in normal man...
  2. pmc Experimental panic provocation in healthy man-a translational role in anti-panic drug development?
    Michael Kellner
    University Hospital Hamburg Eppendorf, Dept of Psychiatry and Psychotherapy, Anxiety Spectrum Disorders Unit, Hamburg, Germany
    Dialogues Clin Neurosci 13:485-93. 2011
    ....
  3. ncbi request reprint Overnight metyrapone and combined dexamethasone/metyrapone tests in post-traumatic stress disorder: preliminary findings
    Michael Kellner
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Eur Neuropsychopharmacol 14:337-9. 2004
    ..Dose-response studies using metyrapone and glucocorticoid agonists are needed to further investigate HPA axis regulation in PTSD...
  4. ncbi request reprint Metyrapone tests in patients with panic disorder
    Michael Kellner
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Biol Psychiatry 56:898-900. 2004
    ..No data about the hypothalamic-pituitary response to metyrapone are available...
  5. ncbi request reprint Effects of a metabotropic glutamate(2/3) receptor agonist (LY544344/LY354740) on panic anxiety induced by cholecystokinin tetrapeptide in healthy humans: preliminary results
    Michael Kellner
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Psychopharmacology (Berl) 179:310-5. 2005
    ..Preclinical findings have repeatedly shown an anxiolytic-like action of agonists at metabotropic glutamate receptors type II, such as LY354740...
  6. doi request reprint Mineralocorticoid receptors in brain, in health and disease: possibilities for new pharmacotherapy
    Michael Kellner
    University Hospital Hamburg Eppendorf, Department of Psychiatry and Psychotherapy, Martinistrasse 52, D 20246 Hamburg, Germany
    Eur J Pharmacol 583:372-8. 2008
    ..Nevertheless, recent research findings promise possibilities for new pharmacotherapy via modulation of mineralocorticoid receptor function...
  7. doi request reprint The selective serotonin re-uptake inhibitor escitalopram modulates the panic response to cholecystokinin tetrapeptide in healthy men depending on 5-HTTLPR genotype
    Michael Kellner
    University Hospital Hamburg Eppendorf, Department of Psychiatry, Martinistrasse 52, D 20246 Hamburg, Germany
    J Psychiatr Res 43:642-8. 2009
    ..The biological underpinnings of the increased panic symptoms after escitalopram in our volunteers with short/short genotype need further research...
  8. ncbi request reprint Trait dissociation affects the behavioral response to cholecystokinin tetrapeptide in healthy man
    Michael Kellner
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Martinistrasse 52, D 20246, Hamburg, Germany
    Psychiatry Res 111:93-6. 2002
    ..Trait dissociation should be assessed in further behavioral challenge studies as a potentially important covariate...
  9. doi request reprint No effect of six weeks of treatment with escitalopram on mood in healthy volunteers--irrespective of genotype for the promoter of the serotonin transporter
    Michael Kellner
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Psychiatry Res 161:339-43. 2008
    ..No significant effect on negative affect, positive affect, or state anxiety was detected, irrespective of serotonin transporter gene-linked polymorphism...
  10. doi request reprint Increased DHEA and DHEA-S plasma levels in patients with post-traumatic stress disorder and a history of childhood abuse
    Michael Kellner
    University Hospital Hamburg Eppendorf, Department of Psychiatry and Psychotherapy, Martinistrasse 52, D 20246 Hamburg, Germany
    J Psychiatr Res 44:215-9. 2010
    ..Further studies are needed to clarify the potential role of DHEA and DHEA-S as biomarkers for severe early adverse events in patients suffering from PTSD and in other stress-related disorders...
  11. pmc Drug treatment of obsessive-compulsive disorder
    Michael Kellner
    University Hospital Hamburg Eppendorf, Dept of Psychiatry and Psychotherapy, Anxiety Spectrum Disorders Unit, Hamburg, Germany
    Dialogues Clin Neurosci 12:187-97. 2010
    ..Novel research approaches, such as preliminary treatment studies with glutamatergic substances, and trials with further drugs, as well as needed aspects of future research, are reviewed...
  12. ncbi request reprint Anxiolyticlike effects of atrial natriuretic peptide on cholecystokinin tetrapeptide-induced panic attacks: preliminary findings
    K Wiedemann
    Department of Psychiatry and Psychotherapy, University of Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
    Arch Gen Psychiatry 58:371-7. 2001
    ....
  13. ncbi request reprint Effects of natriuretic peptides upon hypothalamo-pituitary-adrenocortical system activity and anxiety behaviour
    K Wiedemann
    University of Hamburg, Dept of Psychiatry and Psychotherapy, Germany
    Exp Clin Endocrinol Diabetes 108:5-13. 2000
    ..Hence, it may be surmised that in man and rodents ANP reduces anxiety and terminates panic attacks and their neuroendocrine sequelae...
  14. ncbi request reprint Neuroendocrine effects of a short-term osmotic stimulus in patients with chronic schizophrenia
    W Hundt
    Department of Psychiatry and Psychotherapy, University Hospital Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    World J Biol Psychiatry 2:27-33. 2001
    ....
  15. ncbi request reprint Corticotropin-releasing hormone inhibits melatonin secretion in healthy volunteers--a potential link to low-melatonin syndrome in depression?
    M Kellner
    Department of Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany
    Neuroendocrinology 65:284-90. 1997
    ....
  16. ncbi request reprint Comparison of the effects of endothelin-1 and -3 on secretion of pituitary hormones in healthy male volunteers
    F Kiefer
    Department of Psychiatry, University Hospital Eppendorf, Hamburg, Germany
    Exp Clin Endocrinol Diabetes 108:378-81. 2000
    ..Whether this supports a possible role of ET-1 as a modulator of the hypothalamo-pituitary-adrenal (HPA) axis remains to be clarified...
  17. ncbi request reprint Sleep endocrine effects of the 11-beta-hydroxysteroiddehydrogenase inhibitor metyrapone
    Holger Jahn
    Department of Psychiatry and Psychotherapy, University of Hamburg, Hamburg, Germany
    Sleep 26:823-9. 2003
    ....
  18. ncbi request reprint Prolactin but not ACTH increases during sodium lactate-induced panic attacks
    Christian Otte
    University Hospital Hamburg Eppendorf, Department of Psychiatry and Psychotherapy, Martinistrasse 52, 20246, Germany
    Psychiatry Res 109:201-5. 2002
    ..Prolactin release was significantly elevated (P < 0.05) in panickers compared with non-panickers, whereas ACTH secretion was not activated at all. This differential stress response needs further investigation...
  19. ncbi request reprint Longitudinal course of salivary cortisol in post-traumatic stress disorder
    Michael Kellner
    University Hospital Hamburg Eppendorf, Department of Psychiatry and Psychotherapy, Hamburg, Germany
    Acta Psychiatr Scand 105:153-5; discussion 155-6. 2002
    ..However, so far no longitudinal data on the natural course or on the effect of therapy are available...
  20. ncbi request reprint Mineralocorticoid receptor function in patients with posttraumatic stress disorder
    Michael Kellner
    Depatment of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Germany
    Am J Psychiatry 159:1938-40. 2002
    ....
  21. ncbi request reprint Salivary cortisol levels and the cortisol response to dexamethasone before and after EMDR: a case report
    Ruth Heber
    Mount Sinai School of Medicine, USA
    J Clin Psychol 58:1521-30. 2002
    ..These results suggest the potential utility of including neuroendocrine measures in the assessment of treatment outcome in PTSD...
  22. ncbi request reprint A combined dexamethasone/corticotropin-releasing hormone test in patients with chronic PTSD--first preliminary results
    Christoph Muhtz
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    J Psychiatr Res 42:689-93. 2008
    ..More refined laboratory tests and subgrouping of PTSD patients might help to decrease variance of findings...
  23. ncbi request reprint Blockade of the mineralocorticoid receptor in healthy men: effects on experimentally induced panic symptoms, stress hormones, and cognition
    Christian Otte
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Neuropsychopharmacology 32:232-8. 2007
    ..The domains of cognitive function that are impaired after blockade of MR in men, that is, selective attention, visuospatial memory, and mental flexibility/set shifting appear to be remarkably similar to those described in animal studies...
  24. ncbi request reprint Verbal and nonverbal memory functioning in posttraumatic stress disorder (PTSD)
    Lena Jelinek
    Hospital for Psychiatry and Psychotherapy, University Medical Center Hamburg Eppendorf, Germany
    J Clin Exp Neuropsychol 28:940-8. 2006
    ..The influence of attention, verbal intelligence, and depression was investigated. Our findings suggest that both verbal and nonverbal memory are compromised in PTSD...
  25. ncbi request reprint Mineralocorticoid receptor function in posttraumatic stress disorder after pretreatment with metyrapone
    Christian Otte
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
    Biol Psychiatry 60:784-7. 2006
    ..Alterations of mineralocorticoid receptor (MR) mediated negative feedback inhibition of cortisol might contribute to abnormalities of hypothalamic-pituitary adrenal (HPA) activity in posttraumatic stress disorder (PTSD)...
  26. ncbi request reprint Megestrol attenuates the hormonal response to CCK-4-induced panic attacks
    Thomas J Raedler
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Depress Anxiety 23:139-44. 2006
    ..Further studies in a larger sample of subjects, including both females and patients suffering from panic disorder, seem warranted...
  27. ncbi request reprint Extent, profile and specificity of visuospatial impairment in obsessive-compulsive disorder (OCD)
    Steffen Moritz
    University Hospital of Hamburg, Department of Psychiatry and Psychotherapy, Hamburg, Germany
    J Clin Exp Neuropsychol 27:795-814. 2005
    ..It is suggested that prior research overestimated the severity and significance of visuospatial and nonverbal memory impairment in OCD...
  28. ncbi request reprint Endocrine and cardiovascular responses to corticotropin-releasing hormone in patients with posttraumatic stress disorder: a role for atrial natriuretic peptide?
    Michael Kellner
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Neuropsychobiology 47:102-8. 2003
    ..Further studies to assess ANP secretion in PTSD patients and to clarify its pathophysiological impact are needed...
  29. ncbi request reprint Metyrapone as additive treatment in major depression: a double-blind and placebo-controlled trial
    Holger Jahn
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Arch Gen Psychiatry 61:1235-44. 2004
    ..Inhibitors of steroid synthesis have been reported to exert antidepressive effects, according to preliminary findings...
  30. ncbi request reprint The mineralocorticoid receptor agonist, fludrocortisone, inhibits pituitary-adrenal activity in humans after pre-treatment with metyrapone
    Christian Otte
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Life Sci 73:1835-45. 2003
    ..05), whereas no such effect was observed after aldosterone or placebo. These preliminary data suggest that MR are involved in the inhibition of the HPA axis during the circadian nadir of glucocorticoid concentrations in humans...
  31. ncbi request reprint Acute effects of megestrol on the hypothalamic-pituitary-adrenal axis
    Thomas J Raedler
    Department of Psychiatry and Psychotherapy, University of Hamburg Medical Center, Martinistr 52, 20246, Hamburg, Germany
    Cancer Chemother Pharmacol 52:482-6. 2003
    ..As part of an endocrine study, we evaluated the acute effects of megestrol, hydrocortisone and placebo on morning cortisol and ACTH levels...
  32. ncbi request reprint Mineralocorticoid receptor-mediated inhibition of the hypothalamic-pituitary-adrenal axis in aged humans
    Christian Otte
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Gerontol A Biol Sci Med Sci 58:B900-5. 2003
    ..Our results implicate that a decrease in MR-mediated negative feedback contributes to the diminished feedback activity in older humans...
  33. ncbi request reprint Modulation of sympathetic activity by corticotropin-releasing hormone and atrial natriuretic peptide
    Josef Arlt
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
    Neuropeptides 37:362-8. 2003
    ..Hence, we attempted to investigate the ANS-effects of a CRH bolus and the modulatory influences of atrial natriuretic peptide (ANP), one of the most important functional antagonist of CRH actions...
  34. ncbi request reprint Valproate monotherapy in the treatment of civilian patients with non-combat-related posttraumatic stress disorder: an open-label study
    Christian Otte
    J Clin Psychopharmacol 24:106-8. 2004