Ziya Kaya

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. pmc Complement receptors regulate lipopolysaccharide-induced T-cell stimulation
    Ziya Kaya
    Department of Internal Medicine III Cardiology, University of Heidelberg, Heidelberg, Germany
    Immunology 114:493-8. 2005
  2. doi request reprint Role of the cholinergic antiinflammatory pathway in murine autoimmune myocarditis
    Christoph Leib
    Department of Internal Medicine III, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Circ Res 109:130-40. 2011
  3. pmc Identification of cardiac troponin I sequence motifs leading to heart failure by induction of myocardial inflammation and fibrosis
    Ziya Kaya
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Circulation 118:2063-72. 2008
  4. doi request reprint Mucosal tolerance induction in autoimmune myocarditis and myocardial infarction
    Jin Li
    Department of Cardiology, University of Heidelberg, Germany
    Int J Cardiol 162:245-52. 2013
  5. doi request reprint Effects of protein A immunoadsorption in patients with chronic dilated cardiomyopathy
    Andreas O Doesch
    Department of Cardiology, University of Heidelberg, 69120 Heidelberg, Germany
    J Clin Apher 25:315-22. 2010
  6. doi request reprint Autoimmunity against cardiac troponin I in ischaemia reperfusion injury
    H Christian Volz
    Department of Cardiology, University of Heidelberg, Im Neuenheimer Feld 410, Heidelberg, Germany
    Eur J Heart Fail 13:1052-9. 2011
  7. doi request reprint Comparison of IL-10 and MCP-1-7ND gene transfer with AAV9 vectors for protection from murine autoimmune myocarditis
    Ziya Kaya
    Department of Internal Medicine III, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Cardiovasc Res 91:116-23. 2011
  8. doi request reprint S100A8/A9 aggravates post-ischemic heart failure through activation of RAGE-dependent NF-κB signaling
    H Christian Volz
    Department of Medicine III, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany
    Basic Res Cardiol 107:250. 2012
  9. doi request reprint Autoimmune myocarditis: past, present and future
    Florian Leuschner
    Department of Cardiology, University of Heidelberg, 69120 Heidelberg, Germany
    J Autoimmun 33:282-9. 2009
  10. pmc HMGB1 is associated with atherosclerotic plaque composition and burden in patients with stable coronary artery disease
    Martin Andrassy
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    PLoS ONE 7:e52081. 2012

Collaborators

Detail Information

Publications25

  1. pmc Complement receptors regulate lipopolysaccharide-induced T-cell stimulation
    Ziya Kaya
    Department of Internal Medicine III Cardiology, University of Heidelberg, Heidelberg, Germany
    Immunology 114:493-8. 2005
    ..These findings point to a novel mechanism by which CR1/CR2 modulates the activation of T cells by LPS...
  2. doi request reprint Role of the cholinergic antiinflammatory pathway in murine autoimmune myocarditis
    Christoph Leib
    Department of Internal Medicine III, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Circ Res 109:130-40. 2011
    ..This study was performed to gain insights into novel therapeutic approaches for the treatment of autoimmune myocarditis...
  3. pmc Identification of cardiac troponin I sequence motifs leading to heart failure by induction of myocardial inflammation and fibrosis
    Ziya Kaya
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    Circulation 118:2063-72. 2008
    ..Recently, we showed that an autoimmune response to cardiac troponin I (cTnI) induces severe inflammation and subsequent fibrosis in the myocardium. This autoimmune disorder predisposes to heart failure and cardiac death in mice...
  4. doi request reprint Mucosal tolerance induction in autoimmune myocarditis and myocardial infarction
    Jin Li
    Department of Cardiology, University of Heidelberg, Germany
    Int J Cardiol 162:245-52. 2013
    ..We studied the effects of mucosal tolerance induction on cTnI-induced experimental autoimmune myocarditis (EAM) and post-infarct remodeling...
  5. doi request reprint Effects of protein A immunoadsorption in patients with chronic dilated cardiomyopathy
    Andreas O Doesch
    Department of Cardiology, University of Heidelberg, 69120 Heidelberg, Germany
    J Clin Apher 25:315-22. 2010
    ..The objective of this study was to investigate functional effects of immunoadsorption (IA) in patients with chronic nonfamilial dilated cardiomyopathy (DCM) regarding clinical and humoral markers of heart failure...
  6. doi request reprint Autoimmunity against cardiac troponin I in ischaemia reperfusion injury
    H Christian Volz
    Department of Cardiology, University of Heidelberg, Im Neuenheimer Feld 410, Heidelberg, Germany
    Eur J Heart Fail 13:1052-9. 2011
    ..Furthermore, we studied the effects of cTnI-autoimmunity on the infarcted myocardium following revascularization measures in terms of ischaemia reperfusion injury (IRI), which resembles clinical reality more closely...
  7. doi request reprint Comparison of IL-10 and MCP-1-7ND gene transfer with AAV9 vectors for protection from murine autoimmune myocarditis
    Ziya Kaya
    Department of Internal Medicine III, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Cardiovasc Res 91:116-23. 2011
    ....
  8. doi request reprint S100A8/A9 aggravates post-ischemic heart failure through activation of RAGE-dependent NF-κB signaling
    H Christian Volz
    Department of Medicine III, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany
    Basic Res Cardiol 107:250. 2012
    ..Our study provides evidence that sustained activation of S100A8/A9 critically contributes to the development of post-ischemic HF driving the progressive course of HF through activation of RAGE...
  9. doi request reprint Autoimmune myocarditis: past, present and future
    Florian Leuschner
    Department of Cardiology, University of Heidelberg, 69120 Heidelberg, Germany
    J Autoimmun 33:282-9. 2009
    ....
  10. pmc HMGB1 is associated with atherosclerotic plaque composition and burden in patients with stable coronary artery disease
    Martin Andrassy
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    PLoS ONE 7:e52081. 2012
    ..In this study, we sought to investigate the association of plasma HMGB1 with coronary plaque composition in patients with suspected or known coronary artery disease (CAD)...
  11. doi request reprint HMGB1: the missing link between diabetes mellitus and heart failure
    H Christian Volz
    Department of Medicine III, University of Heidelberg, INF 410, 69120, Heidelberg, Germany
    Basic Res Cardiol 105:805-20. 2010
    ..Therefore, blockage of HMGB1 might represent a therapeutic strategy to reduce post-ischemic remodeling in DM...
  12. ncbi request reprint Absence of auto-antibodies against cardiac troponin I predicts improvement of left ventricular function after acute myocardial infarction
    Florian Leuschner
    Department of Internal Medicine III, Cardiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Eur Heart J 29:1949-55. 2008
    ..Others have shown that auto-antibodies to cTnI are present in patients with acute coronary syndrome, but little is known about the clinical relevance of detected cTnI-Ab...
  13. pmc Cardiac troponins and autoimmunity: their role in the pathogenesis of myocarditis and of heart failure
    Ziya Kaya
    Department of Cardiology, University of Heidelberg, 69120 Heidelberg, Germany
    Clin Immunol 134:80-8. 2010
    ..Finally we identified an 18-mer of troponin I containing an immuno-dominant epitope...
  14. doi request reprint Impact of troponin I-autoantibodies in chronic dilated and ischemic cardiomyopathy
    Andreas O Doesch
    Department of Cardiology, University of Heidelberg, 69120 Heidelberg, Germany
    Basic Res Cardiol 106:25-35. 2011
    ..This might possibly indicate a prophylactic effect of TNI-autoantibodies in this subgroup of patients, encouraging further studies into possible protective effects of antibodies against certain cardiac target structures...
  15. doi request reprint The role of HMGB1/RAGE in inflammatory cardiomyopathy
    Hans C Volz
    Department of Medicine III, University of Heidelberg, Heidelberg, Germany
    Semin Thromb Hemost 36:185-94. 2010
    ..Thus HMGB1-antagonizing gene therapy represents a new therapeutic strategy...
  16. doi request reprint Cholinergic control of inflammation in cardiovascular diseases
    Christoph Leib
    Department of Internal Medicine III, University of Heidelberg, Heidelberg, Germany
    Trends Cardiovasc Med 23:46-51. 2013
    ..Furthermore, clinical and experimental studies that investigate the role of vagus nerve stimulation in cardiovascular diseases will be discussed...
  17. ncbi request reprint Cardiac troponin I but not cardiac troponin T induces severe autoimmune inflammation in the myocardium
    Stefan Göser
    Department of Internal Medicine III, University of Heidelberg, 69120 Heidelberg, Germany
    Circulation 114:1693-702. 2006
    ..Thus, the cardiac troponins are paramount for disease classification and risk stratification. However, little is known about the long-term effects of the released troponins on cardiac function...
  18. doi request reprint Autoantibodies in heart failure and cardiac dysfunction
    Ziya Kaya
    Department of Internal Medicine III, University of Heidelberg, Germany
    Circ Res 110:145-58. 2012
    ..Finally the beneficial therapeutic effects of numerous clinical studies that target the humoral arm of the immune system by using either intravenous immunoglobulins and/or immunoadsorption will be critically discussed...
  19. ncbi request reprint High-mobility group box-1 in ischemia-reperfusion injury of the heart
    Martin Andrassy
    Department of Medicine III, University of Heidelberg, Heidelberg, Germany
    Circulation 117:3216-26. 2008
    ..Although HMGB1 has been implicated in ischemia/reperfusion (I/R) injury of the liver and lung, its role in I/R injury of the heart remains unclear...
  20. doi request reprint Effects of protein A immunoadsorption in patients with advanced chronic dilated cardiomyopathy
    Andreas O Doesch
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany
    J Clin Apher 24:141-9. 2009
    ....
  21. doi request reprint Donor dopamine treatment in brain dead rats is associated with an improvement in renal function early after transplantation and a reduction in renal inflammation
    Simone Hoeger
    Department of Medicine V, Nephrology Endocrinology Rheumatology, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany
    Transpl Int 21:1072-80. 2008
    ..No difference for macrophage chemoattractant protein 1 and IL-10 were found. These findings may explain the salutary effect of donor dopamine treatment in renal transplantation...
  22. doi request reprint Provocation of an autoimmune response to cardiac voltage-gated sodium channel NaV1.5 induces cardiac conduction defects in rats
    Sevil Korkmaz
    Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
    J Am Coll Cardiol 62:340-9. 2013
    ..This study sought to test the hypothesis that inducing an autoimmune response against the cardiac sodium channel (NaV1.5) induces arrhythmias...
  23. ncbi request reprint Critical role for monocyte chemoattractant protein-1 and macrophage inflammatory protein-1alpha in induction of experimental autoimmune myocarditis and effective anti-monocyte chemoattractant protein-1 gene therapy
    Stefan Göser
    Department of Internal Medicine III, University of Heidelberg, Germany
    Circulation 112:3400-7. 2005
    ..To determine their critical role in the pathogenesis of myocarditis, we inhibited mononuclear cell activation and migration to see if it would affect disease severity and disease prevalence in experimental autoimmune myocarditis (EAM)...
  24. ncbi request reprint Complement receptor 1 and 2 deficiency increases coxsackievirus B3-induced myocarditis, dilated cardiomyopathy, and heart failure by increasing macrophages, IL-1beta, and immune complex deposition in the heart
    Delisa Fairweather
    Department of Environmental Health Sciences, Johns Hopkins University and Bloomberg School of Public Health, 615 North Wolfe Street, Rm E7628, Baltimore, MD 21205, USA
    J Immunol 176:3516-24. 2006
    ..These results show that expression of CR1/2 is not necessary for effective clearance of CVB3 infection, but prevents immune-mediated damage to the heart...
  25. pmc Impaired up-regulation of CD25 on CD4+ T cells in IFN-gamma knockout mice is associated with progression of myocarditis to heart failure
    Marina Afanasyeva
    Department of Pathology, The Johns Hopkins Medical Institutions, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 102:180-5. 2005
    ..An exaggerated inflammatory response in IFN-gamma KO mice causes cardiac dysfunction, leading to dilated cardiomyopathy and heart failure...