Research Topics
Genomes and Genes
| Hamid KashkarSummaryAffiliation: University of Cologne Country: Germany Publications
| Collaborators
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Detail Information
Publications
X-linked inhibitor of apoptosis: a chemoresistance factor or a hollow promiseHamid Kashkar
Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Koln, Germany
Clin Cancer Res 16:4496-502. 2010....
XIAP targeting sensitizes Hodgkin lymphoma cells for cytolytic T-cell attackHamid Kashkar
Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Goldenfelsstrasse 19 21, 50935 Köln, Germany
Blood 108:3434-40. 2006..The results suggest that XIAP targeting by Smac agonists or XIAP-siRNA can be used as a synergistic strategy for cellular immunotherapy of Hodgkin lymphoma...- NF-kappaB-independent down-regulation of XIAP by bortezomib sensitizes HL B cells against cytotoxic drugsHamid Kashkar
Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Goldenfelsstrasse 19 21, 50935 Köln, Germany
Blood 109:3982-8. 2007..The results identify XIAP as an NF-kappaB-independent target of bortezomib action that controls the chemoresistant phenotype of HL cells... - The proteasome inhibitor bortezomib sensitizes melanoma cells toward adoptive CTL attackJens Michael Seeger
Institute for Medical Microbiology, Immunology and Hygiene, Medical Faculty, University of Cologne, Cologne, Germany
Cancer Res 70:1825-34. 2010..Our data indicate that proteasome inhibition increases the sensitivity of tumor cells toward cytolytic T-cell attack by NOXA-mediated enhancement of mitochondrial SMAC release... - Riboflavin kinase couples TNF receptor 1 to NADPH oxidaseBenjamin Yazdanpanah
Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany
Nature 460:1159-63. 2009..The results suggest that TNF, through the activation of RFK, enhances the incorporation of FAD in NADPH oxidase enzymes, a critical step for the assembly and activation of NADPH oxidase... - Acid sphingomyelinase is indispensable for UV light-induced Bax conformational change at the mitochondrial membraneHamid Kashkar
Institute for Medical Microbiology, Immunology and Hygiene and Center for Molecular Medicine Cologne, University of Cologne, 50935 Cologne, Germany
J Biol Chem 280:20804-13. 2005..The results suggest that UV light-triggered ASMase activation is essentially required for Bax conformational change leading to mitochondrial release of pro-apoptotic factors like cytochrome c and Smac... 
PtdIns(4,5)P-restricted plasma membrane localization of FAN is involved in TNF-induced actin reorganizationDirk Haubert
Institute for Medical Microbiology, Immunology and Hygiene, Medical Faculty, University of Cologne, Cologne, Germany
EMBO J 26:3308-21. 2007..The results of this study suggest that PH-mediated plasma membrane targeting of FAN is critically involved in TNF-induced Cdc42 activation and cytoskeleton reorganization...- Overexpression of TOSO in CLL is triggered by B-cell receptor signaling and associated with progressive diseaseChristian Philipp Pallasch
Laboratory of Cellular Immunotherapy, Clinic I of Internal Medicine, University of Cologne, Cologne, Germany
Blood 112:4213-9. 2008..Both association with unmutated IgV(H) and the specific induction of TOSO via the BCR suggest autoreactive BCR signaling as a key mediator of apoptosis resistance in CLL... - Selection of potent non-toxic inhibitory sequences from a randomized HIV-1 specific lentiviral short hairpin RNA libraryCarola Pongratz
Institute for Medical Microbiology, Immunology and Hygiene, University Hospital Cologne, Cologne, Germany
PLoS ONE 5:e13172. 2010.... - Acid sphingomyelinase is a key regulator of cytotoxic granule secretion by primary T lymphocytesJasmin Herz
Institute for Medical Microbiology, Immunology and Hygiene, Medical Center, University of Cologne, Germany
Nat Immunol 10:761-8. 2009..In ASMase-KO CD8+ T cells, the contraction of secretory granules was markedly impaired. Thus, ASMase is required for contraction of secretory granules and expulsion of cytotoxic effector molecules... - Factor associated with neutral sphingomyelinase activity mediates navigational capacity of leukocytes responding to wounds and infection: live imaging studies in zebrafish larvaeAlexandra Boecke
Institute for Medical Microbiology, Immunology, and Hygiene, University of Cologne, 50935 Cologne, Germany
J Immunol 189:1559-66. 2012..Our results suggest that FAN-deficient leukocytes exhibit an impaired navigational capacity, leading to a disrupted chemotactic response... - Serpin-6 expression protects embryonic stem cells from lysis by antigen-specific CTLZeinab Abdullah
Institute for Medical Microbiology, Immunology and Hygiene, Medical Center, University of Cologne, Goldenfelsstrasse 19 21, 50935 Cologne, Germany
J Immunol 178:3390-9. 2007.... - Staphylococcus aureus subvert autophagy for induction of caspase-independent host cell deathAnnabelle Schnaith
Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, 50935 Cologne, Germany
J Biol Chem 282:2695-706. 2007..The results of this study suggest that rapid induction of autophagy is essential for S. aureus replication, escape into the cytoplasm, and host cell killing... - Novel tumor necrosis factor-responsive mammalian neutral sphingomyelinase-3 is a C-tail-anchored proteinOleg Krut
Institute for Medical Microbiology, Immunology, and Hygiene, Center for Molecular Medicine Cologne, University of Cologne, 50935 Köln, Germany
J Biol Chem 281:13784-93. 2006..Tumor necrosis factor stimulates rapid activation of nSMase3 in MCF7 cells with peak activity at 1.5 min, which was impaired by expression of dominant negative FAN... - Novel X-linked inhibitor of apoptosis inhibiting compound as sensitizer for TRAIL-mediated apoptosis in chronic lymphocytic leukaemia with poor prognosisLukas P Frenzel
Department I of Internal Medicine, University of Cologne, Germany
Br J Haematol 152:191-200. 2011..Our highly-effective XIAP inhibitor CA, in concert with TRAIL, shows potential for the treatment of CLL cases with poor prognosis and therefore warrants further clinical investigation... - XIAP-mediated caspase inhibition in Hodgkin's lymphoma-derived B cellsHamid Kashkar
Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Goldenfelsstrasse 19-21, 50935 Cologne, Germany
J Exp Med 198:341-7. 2003..The results of this paper suggest that high level XIAP expression is a hallmark of HL, which may play a crucial role in resistance to apoptosis... - Interleukin-6 is essential for zwitterionic polysaccharide-mediated abscess formationSonja Meemboor
Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne Medical Centre, Cologne, Germany
Innate Immun 16:310-21. 2010..The data delineate the essential role of IL-6 in the linkage of innate and adaptive immunity in polysaccharide-mediated abscess formation... - Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolismSabine D Jordan
Department of Mouse Genetics and Metabolism, Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases CECAD, University of Cologne, University Hospital Cologne, Max Planck Institute for Neurological Research, Zulpicher Strasse 47, D 50674 Cologne, Germany
Nat Cell Biol 13:434-46. 2011.... - Crystal structure of the BEACH domain reveals an unusual fold and extensive association with a novel PH domainGerwald Jogl
Department of Biological Sciences, Columbia University, New York, NY 10027, USA
EMBO J 21:4785-95. 2002..Functional studies in intact cells demonstrate the requirement of both the PH and the BEACH domains for activity. A prominent groove at the interface between the two domains may be used to recruit their binding partners...