Hamid Kashkar

Summary

Affiliation: University of Cologne
Country: Germany

Publications

  1. pmc Elevated XIAP expression alone does not confer chemoresistance
    J M Seeger
    Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Goldenfelsstrasse 19 21, 50935 Köln, Germany
    Br J Cancer 102:1717-23. 2010
  2. pmc Targeting the mitochondrial apoptotic pathway: a preferred approach in hematologic malignancies?
    K Brinkmann
    1 Centre for Molecular Medicine Cologne CMMC, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases CECAD, Koln, Germany 2 Institute for Medical Microbiology, Immunology and Hygiene IMMIH, University of Cologne, Koln, Germany
    Cell Death Dis 5:e1098. 2014
  3. doi request reprint X-linked inhibitor of apoptosis: a chemoresistance factor or a hollow promise
    Hamid Kashkar
    Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Koln, Germany
    Clin Cancer Res 16:4496-502. 2010
  4. ncbi request reprint XIAP targeting sensitizes Hodgkin lymphoma cells for cytolytic T-cell attack
    Hamid Kashkar
    Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Goldenfelsstrasse 19 21, 50935 Köln, Germany
    Blood 108:3434-40. 2006
  5. ncbi request reprint NF-kappaB-independent down-regulation of XIAP by bortezomib sensitizes HL B cells against cytotoxic drugs
    Hamid Kashkar
    Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Goldenfelsstrasse 19 21, 50935 Köln, Germany
    Blood 109:3982-8. 2007
  6. doi request reprint The proteasome inhibitor bortezomib sensitizes melanoma cells toward adoptive CTL attack
    Jens Michael Seeger
    Institute for Medical Microbiology, Immunology and Hygiene, Medical Faculty, University of Cologne, Cologne, Germany
    Cancer Res 70:1825-34. 2010
  7. doi request reprint Riboflavin kinase couples TNF receptor 1 to NADPH oxidase
    Benjamin Yazdanpanah
    Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany
    Nature 460:1159-63. 2009
  8. ncbi request reprint Acid sphingomyelinase is indispensable for UV light-induced Bax conformational change at the mitochondrial membrane
    Hamid Kashkar
    Institute for Medical Microbiology, Immunology and Hygiene and Center for Molecular Medicine Cologne, University of Cologne, 50935 Cologne, Germany
    J Biol Chem 280:20804-13. 2005
  9. doi request reprint Second mitochondria-derived activator of caspase (SMAC) mimetic potentiates tumor susceptibility toward natural killer cell-mediated killing
    Kerstin Brinkmann
    Center for Molecular Medicine Cologne CMMC, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases CECAD and Institute for Medical Microbiology, Immunology and Hygiene IMMIH, University of Cologne, Cologne, Germany
    Leuk Lymphoma 55:645-51. 2014
  10. doi request reprint Ubiquitin C-terminal hydrolase-L1 potentiates cancer chemosensitivity by stabilizing NOXA
    Kerstin Brinkmann
    Centre for Molecular Medicine Cologne and Institute for Medical Microbiology, Immunology and Hygiene, University Hospital of Cologne, 50935 Cologne, Germany
    Cell Rep 3:881-91. 2013

Collaborators

Detail Information

Publications27

  1. pmc Elevated XIAP expression alone does not confer chemoresistance
    J M Seeger
    Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Goldenfelsstrasse 19 21, 50935 Köln, Germany
    Br J Cancer 102:1717-23. 2010
    ....
  2. pmc Targeting the mitochondrial apoptotic pathway: a preferred approach in hematologic malignancies?
    K Brinkmann
    1 Centre for Molecular Medicine Cologne CMMC, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases CECAD, Koln, Germany 2 Institute for Medical Microbiology, Immunology and Hygiene IMMIH, University of Cologne, Koln, Germany
    Cell Death Dis 5:e1098. 2014
    ....
  3. doi request reprint X-linked inhibitor of apoptosis: a chemoresistance factor or a hollow promise
    Hamid Kashkar
    Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Koln, Germany
    Clin Cancer Res 16:4496-502. 2010
    ....
  4. ncbi request reprint XIAP targeting sensitizes Hodgkin lymphoma cells for cytolytic T-cell attack
    Hamid Kashkar
    Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Goldenfelsstrasse 19 21, 50935 Köln, Germany
    Blood 108:3434-40. 2006
    ..The results suggest that XIAP targeting by Smac agonists or XIAP-siRNA can be used as a synergistic strategy for cellular immunotherapy of Hodgkin lymphoma...
  5. ncbi request reprint NF-kappaB-independent down-regulation of XIAP by bortezomib sensitizes HL B cells against cytotoxic drugs
    Hamid Kashkar
    Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Goldenfelsstrasse 19 21, 50935 Köln, Germany
    Blood 109:3982-8. 2007
    ..The results identify XIAP as an NF-kappaB-independent target of bortezomib action that controls the chemoresistant phenotype of HL cells...
  6. doi request reprint The proteasome inhibitor bortezomib sensitizes melanoma cells toward adoptive CTL attack
    Jens Michael Seeger
    Institute for Medical Microbiology, Immunology and Hygiene, Medical Faculty, University of Cologne, Cologne, Germany
    Cancer Res 70:1825-34. 2010
    ..Our data indicate that proteasome inhibition increases the sensitivity of tumor cells toward cytolytic T-cell attack by NOXA-mediated enhancement of mitochondrial SMAC release...
  7. doi request reprint Riboflavin kinase couples TNF receptor 1 to NADPH oxidase
    Benjamin Yazdanpanah
    Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany
    Nature 460:1159-63. 2009
    ..The results suggest that TNF, through the activation of RFK, enhances the incorporation of FAD in NADPH oxidase enzymes, a critical step for the assembly and activation of NADPH oxidase...
  8. ncbi request reprint Acid sphingomyelinase is indispensable for UV light-induced Bax conformational change at the mitochondrial membrane
    Hamid Kashkar
    Institute for Medical Microbiology, Immunology and Hygiene and Center for Molecular Medicine Cologne, University of Cologne, 50935 Cologne, Germany
    J Biol Chem 280:20804-13. 2005
    ..The results suggest that UV light-triggered ASMase activation is essentially required for Bax conformational change leading to mitochondrial release of pro-apoptotic factors like cytochrome c and Smac...
  9. doi request reprint Second mitochondria-derived activator of caspase (SMAC) mimetic potentiates tumor susceptibility toward natural killer cell-mediated killing
    Kerstin Brinkmann
    Center for Molecular Medicine Cologne CMMC, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases CECAD and Institute for Medical Microbiology, Immunology and Hygiene IMMIH, University of Cologne, Cologne, Germany
    Leuk Lymphoma 55:645-51. 2014
    ..Our data highlight for the first time the specific use of SMAC mimetics for boosting immune cell-mediated immunotherapy, representing a novel and promising approach in the treatment of cancer...
  10. doi request reprint Ubiquitin C-terminal hydrolase-L1 potentiates cancer chemosensitivity by stabilizing NOXA
    Kerstin Brinkmann
    Centre for Molecular Medicine Cologne and Institute for Medical Microbiology, Immunology and Hygiene, University Hospital of Cologne, 50935 Cologne, Germany
    Cell Rep 3:881-91. 2013
    ..elegans cells. Our data identify the UCH-L1/NOXA interaction as a therapeutic target for overcoming cancer chemoresistance...
  11. pmc PtdIns(4,5)P-restricted plasma membrane localization of FAN is involved in TNF-induced actin reorganization
    Dirk Haubert
    Institute for Medical Microbiology, Immunology and Hygiene, Medical Faculty, University of Cologne, Cologne, Germany
    EMBO J 26:3308-21. 2007
    ..The results of this study suggest that PH-mediated plasma membrane targeting of FAN is critically involved in TNF-induced Cdc42 activation and cytoskeleton reorganization...
  12. doi request reprint Overexpression of TOSO in CLL is triggered by B-cell receptor signaling and associated with progressive disease
    Christian Philipp Pallasch
    Laboratory of Cellular Immunotherapy, Clinic I of Internal Medicine, University of Cologne, Cologne, Germany
    Blood 112:4213-9. 2008
    ..Both association with unmutated IgV(H) and the specific induction of TOSO via the BCR suggest autoreactive BCR signaling as a key mediator of apoptosis resistance in CLL...
  13. doi request reprint Acid sphingomyelinase is a key regulator of cytotoxic granule secretion by primary T lymphocytes
    Jasmin Herz
    Institute for Medical Microbiology, Immunology and Hygiene, Medical Center, University of Cologne, Germany
    Nat Immunol 10:761-8. 2009
    ..In ASMase-KO CD8+ T cells, the contraction of secretory granules was markedly impaired. Thus, ASMase is required for contraction of secretory granules and expulsion of cytotoxic effector molecules...
  14. pmc Selection of potent non-toxic inhibitory sequences from a randomized HIV-1 specific lentiviral short hairpin RNA library
    Carola Pongratz
    Institute for Medical Microbiology, Immunology and Hygiene, University Hospital Cologne, Cologne, Germany
    PLoS ONE 5:e13172. 2010
    ....
  15. pmc Embelin inhibits endothelial mitochondrial respiration and impairs neoangiogenesis during tumor growth and wound healing
    Oliver Coutelle
    Department I for Internal Medicine, University of Cologne, Cologne, Germany
    EMBO Mol Med 6:624-39. 2014
    ..This novel metabolic targeting approach might be clinically valuable in controlling pathological neoangiogenesis while sparing normal vasculature and complementing cytostatic drugs in cancer treatment. ..
  16. doi request reprint Dimethylfumarate induces apoptosis in human mast cells
    Anja Förster
    Department of Dermatology, University of Cologne, Cologne, Germany
    Exp Dermatol 22:719-24. 2013
    ..Our study contributes to the understanding of the beneficial effects of FAEs in autoimmune diseases and provides a rationale for exploiting FAEs for other diseases associated with mast cells. ..
  17. pmc Factor associated with neutral sphingomyelinase activity mediates navigational capacity of leukocytes responding to wounds and infection: live imaging studies in zebrafish larvae
    Alexandra Boecke
    Institute for Medical Microbiology, Immunology, and Hygiene, University of Cologne, 50935 Cologne, Germany
    J Immunol 189:1559-66. 2012
    ..Our results suggest that FAN-deficient leukocytes exhibit an impaired navigational capacity, leading to a disrupted chemotactic response...
  18. ncbi request reprint Serpin-6 expression protects embryonic stem cells from lysis by antigen-specific CTL
    Zeinab Abdullah
    Institute for Medical Microbiology, Immunology and Hygiene, Medical Center, University of Cologne, Goldenfelsstrasse 19 21, 50935 Cologne, Germany
    J Immunol 178:3390-9. 2007
    ....
  19. doi request reprint Novel X-linked inhibitor of apoptosis inhibiting compound as sensitizer for TRAIL-mediated apoptosis in chronic lymphocytic leukaemia with poor prognosis
    Lukas P Frenzel
    Department I of Internal Medicine, University of Cologne, Germany
    Br J Haematol 152:191-200. 2011
    ..Our highly-effective XIAP inhibitor CA, in concert with TRAIL, shows potential for the treatment of CLL cases with poor prognosis and therefore warrants further clinical investigation...
  20. ncbi request reprint Staphylococcus aureus subvert autophagy for induction of caspase-independent host cell death
    Annabelle Schnaith
    Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, 50935 Cologne, Germany
    J Biol Chem 282:2695-706. 2007
    ..The results of this study suggest that rapid induction of autophagy is essential for S. aureus replication, escape into the cytoplasm, and host cell killing...
  21. ncbi request reprint Novel tumor necrosis factor-responsive mammalian neutral sphingomyelinase-3 is a C-tail-anchored protein
    Oleg Krut
    Institute for Medical Microbiology, Immunology, and Hygiene, Center for Molecular Medicine Cologne, University of Cologne, 50935 Köln, Germany
    J Biol Chem 281:13784-93. 2006
    ..Tumor necrosis factor stimulates rapid activation of nSMase3 in MCF7 cells with peak activity at 1.5 min, which was impaired by expression of dominant negative FAN...
  22. pmc XIAP-mediated caspase inhibition in Hodgkin's lymphoma-derived B cells
    Hamid Kashkar
    Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Goldenfelsstrasse 19 21, 50935 Cologne, Germany
    J Exp Med 198:341-7. 2003
    ..The results of this paper suggest that high level XIAP expression is a hallmark of HL, which may play a crucial role in resistance to apoptosis...
  23. doi request reprint Obesity promotes liver carcinogenesis via Mcl-1 stabilization independent of IL-6Rα signaling
    Sabine Gruber
    Max Planck Institute for Neurological Research Cologne, Institute for Genetics, University of Cologne, 50937 Cologne, Germany
    Cell Rep 4:669-80. 2013
    ..Collectively, this study provides evidence that obesity inhibits hepatocyte apoptosis through Mcl-1 stabilization independent of IL-6 signaling, thus promoting liver carcinogenesis. ..
  24. doi request reprint Anti-Fas/CD95 and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) differentially regulate apoptosis in normal and neoplastic human basophils
    Anja Förster
    Department of Dermatology, University of Cologne, Cologne, Germany
    Leuk Lymphoma 54:835-42. 2013
    ..Our data show that anti-Fas/CD95 and TRAIL differentially regulate apoptosis of normal and neoplastic human basophils, which may direct the development of novel therapeutic strategies...
  25. doi request reprint Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism
    Sabine D Jordan
    Department of Mouse Genetics and Metabolism, Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases CECAD, University of Cologne, University Hospital Cologne, Max Planck Institute for Neurological Research, Zulpicher Strasse 47, D 50674 Cologne, Germany
    Nat Cell Biol 13:434-46. 2011
    ....
  26. doi request reprint Interleukin-6 is essential for zwitterionic polysaccharide-mediated abscess formation
    Sonja Meemboor
    Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne Medical Centre, Cologne, Germany
    Innate Immun 16:310-21. 2010
    ..The data delineate the essential role of IL-6 in the linkage of innate and adaptive immunity in polysaccharide-mediated abscess formation...
  27. pmc Crystal structure of the BEACH domain reveals an unusual fold and extensive association with a novel PH domain
    Gerwald Jogl
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    EMBO J 21:4785-95. 2002
    ..Functional studies in intact cells demonstrate the requirement of both the PH and the BEACH domains for activity. A prominent groove at the interface between the two domains may be used to recruit their binding partners...