Ganna V Kalayda

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. doi request reprint Relevance of copper transporter 1 for cisplatin resistance in human ovarian carcinoma cells
    Ganna V Kalayda
    Pharma Center Bonn, Institute of Pharmacy, Department of Clinical Pharmacy, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany
    J Inorg Biochem 116:1-10. 2012
  2. pmc Altered localisation of the copper efflux transporters ATP7A and ATP7B associated with cisplatin resistance in human ovarian carcinoma cells
    Ganna V Kalayda
    Department of Clinical Pharmacy, Institute of Pharmacy, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany
    BMC Cancer 8:175. 2008
  3. doi request reprint Enhancing lipophilicity as a strategy to overcome resistance against platinum complexes?
    Irina Buss
    Institute of Pharmacy, University of Bonn, Bonn, Germany
    J Inorg Biochem 105:709-17. 2011
  4. doi request reprint Effect of reactivity on cellular accumulation and cytotoxicity of oxaliplatin analogues
    Irina Buß
    Department of Clinical Pharmacy, Institute of Pharmacy, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany
    J Biol Inorg Chem 17:699-708. 2012
  5. doi request reprint Contribution of intracellular ATP to cisplatin resistance of tumor cells
    Verena Schneider
    Department of Clinical Pharmacy, Institute of Pharmacy, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany
    J Biol Inorg Chem 18:165-74. 2013
  6. doi request reprint Cellular accumulation and cytotoxicity of macromolecular platinum complexes in cisplatin-resistant tumor cells
    Dirk Garmann
    Institute of Pharmacy, Department of Clinical Pharmacy, University of Bonn, Germany
    J Control Release 131:100-6. 2008
  7. ncbi request reprint Application of fluorescence microscopy for investigation of cellular distribution of dinuclear platinum anticancer drugs
    Ganna V Kalayda
    Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, P O Box 9502, 2300 RA Leiden, The Netherlands
    J Med Chem 48:5191-202. 2005
  8. ncbi request reprint Dinuclear platinum anticancer complexes with fluorescent N,N'-bis(aminoalkyl)-1,4-diaminoanthraquinones: cellular processing in two cisplatin-resistant cell lines reflects the differences in their resistance profiles
    Ganna V Kalayda
    Gorlaeus Laboratories, Leiden Institute of Chemistry, Leiden University, P O Box 9502, 2300 RA, Leiden, The Netherlands
    J Biol Inorg Chem 10:305-15. 2005
  9. ncbi request reprint Dinuclear platinum complexes with N, N'-bis(aminoalkyl)-1,4-diaminoanthraquinones as linking ligands. Part II. Cellular processing in A2780 cisplatin-resistant human ovarian carcinoma cells: new insights into the mechanism of resistance
    Ganna V Kalayda
    Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, P O Box 9502, 2300 RA, Leiden, The Netherlands
    J Biol Inorg Chem 9:414-22. 2004
  10. ncbi request reprint Dinuclear platinum complexes with N, N'-bis(aminoalkyl)-1,4-diaminoanthraquinones as linking ligands. Part I. Synthesis, cytotoxicity, and cellular studies in A2780 human ovarian carcinoma cells
    Bart A J Jansen
    Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, P O Box 9502, 2300 RA, Leiden, The Netherlands
    J Biol Inorg Chem 9:403-13. 2004

Collaborators

Detail Information

Publications12

  1. doi request reprint Relevance of copper transporter 1 for cisplatin resistance in human ovarian carcinoma cells
    Ganna V Kalayda
    Pharma Center Bonn, Institute of Pharmacy, Department of Clinical Pharmacy, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany
    J Inorg Biochem 116:1-10. 2012
    ..Our findings imply that reduced CTR1 expression accounts for decreased cisplatin accumulation and represents one of the determinants of cisplatin resistance in A2780cis cell line...
  2. pmc Altered localisation of the copper efflux transporters ATP7A and ATP7B associated with cisplatin resistance in human ovarian carcinoma cells
    Ganna V Kalayda
    Department of Clinical Pharmacy, Institute of Pharmacy, University of Bonn, An der Immenburg 4, 53121 Bonn, Germany
    BMC Cancer 8:175. 2008
    ..For this purpose, localisation of ATP7A and ATP7B in A2780 human ovarian carcinoma cells and their cisplatin-resistant variant, A2780cis, was investigated...
  3. doi request reprint Enhancing lipophilicity as a strategy to overcome resistance against platinum complexes?
    Irina Buss
    Institute of Pharmacy, University of Bonn, Bonn, Germany
    J Inorg Biochem 105:709-17. 2011
    ....
  4. doi request reprint Effect of reactivity on cellular accumulation and cytotoxicity of oxaliplatin analogues
    Irina Buß
    Department of Clinical Pharmacy, Institute of Pharmacy, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany
    J Biol Inorg Chem 17:699-708. 2012
    ..Resistance was influenced by lipophilicity but not by reactivity. The observed relationships may help in the design of analogues with high antitumoral activity in oxaliplatin-sensitive as well as oxaliplatin-resistant cells...
  5. doi request reprint Contribution of intracellular ATP to cisplatin resistance of tumor cells
    Verena Schneider
    Department of Clinical Pharmacy, Institute of Pharmacy, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany
    J Biol Inorg Chem 18:165-74. 2013
    ..Higher basal ATP level in cisplatin-resistant cells, which appears to be a consequence of enhanced mitochondrial ATP production, may represent a survival mechanism established during development of resistance...
  6. doi request reprint Cellular accumulation and cytotoxicity of macromolecular platinum complexes in cisplatin-resistant tumor cells
    Dirk Garmann
    Institute of Pharmacy, Department of Clinical Pharmacy, University of Bonn, Germany
    J Control Release 131:100-6. 2008
    ..Macromolecular platinum complexes specially designed to circumvent reduced cellular accumulation may be a promising approach to overcome cisplatin resistance...
  7. ncbi request reprint Application of fluorescence microscopy for investigation of cellular distribution of dinuclear platinum anticancer drugs
    Ganna V Kalayda
    Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, P O Box 9502, 2300 RA Leiden, The Netherlands
    J Med Chem 48:5191-202. 2005
    ..Cellular processing of the CFDA- and DNP-modified dinuclear platinum complexes in U2-OS and U2-OS/Pt cells has been studied...
  8. ncbi request reprint Dinuclear platinum anticancer complexes with fluorescent N,N'-bis(aminoalkyl)-1,4-diaminoanthraquinones: cellular processing in two cisplatin-resistant cell lines reflects the differences in their resistance profiles
    Ganna V Kalayda
    Gorlaeus Laboratories, Leiden Institute of Chemistry, Leiden University, P O Box 9502, 2300 RA, Leiden, The Netherlands
    J Biol Inorg Chem 10:305-15. 2005
    ..In contrast, sequestration in acidic vesicles does not occur in U2-OS/Pt cells that do not exhibit enhanced lysosomal pH and which are likely to have normal endocytosis...
  9. ncbi request reprint Dinuclear platinum complexes with N, N'-bis(aminoalkyl)-1,4-diaminoanthraquinones as linking ligands. Part II. Cellular processing in A2780 cisplatin-resistant human ovarian carcinoma cells: new insights into the mechanism of resistance
    Ganna V Kalayda
    Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, P O Box 9502, 2300 RA, Leiden, The Netherlands
    J Biol Inorg Chem 9:414-22. 2004
    ..Encapsulation of the dinuclear platinum complexes in lysosomal vesicles provides a plausible explanation for the decreased activity of these compounds in the resistant cell line, as compared to the sensitive cell line...
  10. ncbi request reprint Dinuclear platinum complexes with N, N'-bis(aminoalkyl)-1,4-diaminoanthraquinones as linking ligands. Part I. Synthesis, cytotoxicity, and cellular studies in A2780 human ovarian carcinoma cells
    Bart A J Jansen
    Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, P O Box 9502, 2300 RA, Leiden, The Netherlands
    J Biol Inorg Chem 9:403-13. 2004
    ..Co-localization of the anthraquinone fluorescence with Lysotracker Green DND-26 shows that these vesicles are acidic compartments, probably lysosomes...
  11. ncbi request reprint New isomeric azine-bridged dinuclear platinum(II) complexes circumvent cross-resistance to cisplatin
    Seiji Komeda
    Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, P O Box 9502, 2300 RA Leiden, The Netherlands
    J Med Chem 46:1210-9. 2003
    ..Furthermore, these complexes appeared to largely or partly overcome the cross-resistance to cisplatin. Implications of these findings are discussed in the context of a structure-activity relationship for this class of compounds...
  12. ncbi request reprint Structure-toxicity relationships for different types of dinuclear platinum complexes
    Ganna V Kalayda
    Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, P O Box 9502, 2300 RA Leiden, The Netherlands
    J Inorg Biochem 100:1332-8. 2006
    ..Within the group of complexes with flexible ligands, cis-configured isomers are more toxic than their trans-counterparts...