Philipp J Kahle

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain
    P J Kahle
    Adolf Butenandt Institute, Department of Biochemistry, Ludwig Maximilians University, 80336 Munich, Germany
    J Neurosci 20:6365-73. 2000
  2. ncbi Physiology and pathophysiology of alpha-synuclein. Cell culture and transgenic animal models based on a Parkinson's disease-associated protein
    P J Kahle
    Adolf Butenandt Institute, Department of Biochemistry, Ludwig Maximilians University, Schillerstrasse 44, 80336 Munich, Germany
    Ann N Y Acad Sci 920:33-41. 2000
  3. pmc Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model
    P J Kahle
    Laboratory for Alzheimer s and Parkinson s Disease Research, The Department of Biochemistry, Ludwig Maximilians University, Munich, Germany
    Am J Pathol 159:2215-25. 2001
  4. ncbi Structure/function of alpha-synuclein in health and disease: rational development of animal models for Parkinson's and related diseases
    Philipp J Kahle
    Department of Biochemistry, Ludwig Maximilians University, Munich, Germany
    J Neurochem 82:449-57. 2002
  5. pmc Attack on amyloid
    Philipp J Kahle
    Department of Biochemistry, Ludwig Maximilians University, Munich, Germany
    EMBO Rep 4:747-51. 2003
  6. ncbi Pathological properties of the Parkinson's disease-associated protein DJ-1 in alpha-synucleinopathies and tauopathies: relevance for multiple system atrophy and Pick's disease
    Manuela Neumann
    Institute of Neuropathology, Ludwig Maximilians University of Munich, Munich, Germany
    Acta Neuropathol 107:489-96. 2004
  7. ncbi Structural determinants of the C-terminal helix-kink-helix motif essential for protein stability and survival promoting activity of DJ-1
    Karin Görner
    Laboratory of Alzheimer s and Parkinson s Disease Research, Department of Biochemistry, Ludwig Maximilians University of Munich, 80336 Munich, Germany
    J Biol Chem 282:13680-91. 2007
  8. pmc Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies
    Manuela Neumann
    Department of Neuropathology, Ludwig Maximilians University, Munich, Germany
    J Clin Invest 110:1429-39. 2002
  9. ncbi Proteasomal inhibition reduces parkin mRNA in PC12 and SH-SY5Y cells
    Andreas Koch
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistr 15, 81377 Munich, Germany
    Parkinsonism Relat Disord 15:220-5. 2009
  10. ncbi Alpha-synuclein has a high affinity for packing defects in a bilayer membrane: a thermodynamics study
    Brigitte Nuscher
    Department of Biochemistry, Ludwig Maximilian University, 80336 Munich, Germany
    J Biol Chem 279:21966-75. 2004

Collaborators

Detail Information

Publications25

  1. ncbi Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain
    P J Kahle
    Adolf Butenandt Institute, Department of Biochemistry, Ludwig Maximilians University, 80336 Munich, Germany
    J Neurosci 20:6365-73. 2000
    ..Thus, mutant [A30P]alphaSYN does not fail to be transported to synapses, but its transgenic overexpression apparently leads to abnormal cellular accumulations...
  2. ncbi Physiology and pathophysiology of alpha-synuclein. Cell culture and transgenic animal models based on a Parkinson's disease-associated protein
    P J Kahle
    Adolf Butenandt Institute, Department of Biochemistry, Ludwig Maximilians University, Schillerstrasse 44, 80336 Munich, Germany
    Ann N Y Acad Sci 920:33-41. 2000
    ..Thus, Parkinson's disease-associated mutations might perturb axonal transport, leading to somal accumulation of alpha-SYN and eventually Lewy body formation...
  3. pmc Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model
    P J Kahle
    Laboratory for Alzheimer s and Parkinson s Disease Research, The Department of Biochemistry, Ludwig Maximilians University, Munich, Germany
    Am J Pathol 159:2215-25. 2001
    ..In conclusion, the specific accumulation of detergent-insoluble alpha-SYN in transgenic mice recapitulates a pivotal feature of human LB diseases...
  4. ncbi Structure/function of alpha-synuclein in health and disease: rational development of animal models for Parkinson's and related diseases
    Philipp J Kahle
    Department of Biochemistry, Ludwig Maximilians University, Munich, Germany
    J Neurochem 82:449-57. 2002
  5. pmc Attack on amyloid
    Philipp J Kahle
    Department of Biochemistry, Ludwig Maximilians University, Munich, Germany
    EMBO Rep 4:747-51. 2003
  6. ncbi Pathological properties of the Parkinson's disease-associated protein DJ-1 in alpha-synucleinopathies and tauopathies: relevance for multiple system atrophy and Pick's disease
    Manuela Neumann
    Institute of Neuropathology, Ludwig Maximilians University of Munich, Munich, Germany
    Acta Neuropathol 107:489-96. 2004
    ..Our results suggest that DJ-1 is up-regulated in reactive astrocytes as well as in neuronal and glial cells with specific alpha-synucleinopathy and tauopathy...
  7. ncbi Structural determinants of the C-terminal helix-kink-helix motif essential for protein stability and survival promoting activity of DJ-1
    Karin Görner
    Laboratory of Alzheimer s and Parkinson s Disease Research, Department of Biochemistry, Ludwig Maximilians University of Munich, 80336 Munich, Germany
    J Biol Chem 282:13680-91. 2007
    ....
  8. pmc Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies
    Manuela Neumann
    Department of Neuropathology, Ludwig Maximilians University, Munich, Germany
    J Clin Invest 110:1429-39. 2002
    ..The transgenic mice showed a progressive deterioration of locomotor function. Thus, misfolding and hyperphosphorylation of alphaS may cause dysfunction of affected brain regions...
  9. ncbi Proteasomal inhibition reduces parkin mRNA in PC12 and SH-SY5Y cells
    Andreas Koch
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistr 15, 81377 Munich, Germany
    Parkinsonism Relat Disord 15:220-5. 2009
    ....
  10. ncbi Alpha-synuclein has a high affinity for packing defects in a bilayer membrane: a thermodynamics study
    Brigitte Nuscher
    Department of Biochemistry, Ludwig Maximilian University, 80336 Munich, Germany
    J Biol Chem 279:21966-75. 2004
    ..This will be discussed with regard to a possible role of the protein for the stabilization of synaptic vesicle membranes...
  11. ncbi Regional distribution of proteinase K-resistant alpha-synuclein correlates with Lewy body disease stage
    Manuela Neumann
    Institute of Neuropathology, Laboratory of Alzheimer s and Parkinson s Disease Research, Ludwig Maximilians University, Munich, Germany
    J Neuropathol Exp Neurol 63:1225-35. 2004
    ..Variable amounts of neuritic PK-resistant alphaSYN were found in the striatum of all cases. Thus, PK resistance of alphaSYN may be useful for the development of biomarkers of LB diseases...
  12. ncbi Parkin phosphorylation and modulation of its E3 ubiquitin ligase activity
    Ayako Yamamoto
    Laboratory of Alzheimer s and Parkinson s Disease Research, Department of Metabolic Biochemistry, Ludwig Maximilians University, 80336 Munich, Germany
    J Biol Chem 280:3390-9. 2005
    ..Thus, complex regulation of the phosphorylation state of parkin may contribute to the unfolded protein response in stressed cells...
  13. ncbi Alpha-synuclein transgenic mice: relevance to multiple system atrophy
    Gwenaelle Fillon
    Laboratory of Alzheimer s and Parkinson s Disease Research, Department of Biochemistry, Ludwig Maximilians University of Munich, Germany
    Mov Disord 20:S64-6. 2005
    ..Moreover, it will be important to understand what defines the predilection sites most severely affected by striatonigral degeneration (MSA-P) and olivopontocerebellar atrophy (MSA-C), respectively...
  14. ncbi Differential effects of Parkinson's disease-associated mutations on stability and folding of DJ-1
    Karin Görner
    Laboratory of Alzheimer s and Parkinson s Disease Research, Department of Biochemistry, Adolf Butenandt Institute, Ludwig Maximilians University, 80336 Munich, Germany
    J Biol Chem 279:6943-51. 2004
    ..Thus, structural defects of [E64D]DJ-1 only become apparent upon denaturing conditions, whereas the L166P mutation causes a drastic defect that leads to excessive degradation...
  15. pmc How does parkin ligate ubiquitin to Parkinson's disease?
    Philipp J Kahle
    Laboratory of Alzheimer s and Parkinson s Disease Research, Department of Biochemistry, Ludwig Maximilians University of Munich, Schillerstrasse 44, 80336 Munchen, Germany
    EMBO Rep 5:681-5. 2004
    ..The risk factors that predispose dopaminergic neurons to degenerate on parkin failure are yet to be identified...
  16. ncbi Single particle detection and characterization of synuclein co-aggregation
    Armin Giese
    Center for Neuropathology and Prion Research, LMU, Munich, Germany
    Biochem Biophys Res Commun 333:1202-10. 2005
    ....
  17. pmc Hyperphosphorylation and insolubility of alpha-synuclein in transgenic mouse oligodendrocytes
    Philipp J Kahle
    Laboratory for Alzheimer s and Parkinson s Disease Research, Department of Biochemistry, Ludwig Maximilians University, D 80336 Munich, Germany
    EMBO Rep 3:583-8. 2002
    ..Thus, ectopic expression alpha SYN in OLs might initiate salient features of MSA pathology...
  18. ncbi Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin
    Nicole Exner
    Center for Integrated Protein Science Munich and Adolf Butenandt Institute, Department of Biochemistry, Laboratory for Alzheimer s and Parkinson s Disease Research, Ludwig Maximilians University, 80336 Munich, Germany
    J Neurosci 27:12413-8. 2007
    ..Our results may therefore suggest that PINK1 deficiency in humans results in mitochondrial abnormalities associated with cellular stress, a pathological phenotype, which can be ameliorated by enhanced expression of parkin...
  19. doi Parkin protects against tyrosinase-mediated dopamine neurotoxicity by suppressing stress-activated protein kinase pathways
    Takafumi Hasegawa
    Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University Clinics Tübingen, Tubingen, Germany
    J Neurochem 105:1700-15. 2008
    ..PD-associated mutations differentially affected the anti-apoptotic signaling of parkin. Thus, parkin contributes to DAergic neuroprotection by suppression of apoptotic stress-activated protein kinase pathways...
  20. ncbi Microglial activation mediates neurodegeneration related to oligodendroglial alpha-synucleinopathy: implications for multiple system atrophy
    Nadia Stefanova
    Clinical Neurobiology Unit, Neurodegeneration Research Laboratory, Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 22:2196-203. 2007
    ....
  21. ncbi Age-dependent cognitive decline and amygdala pathology in alpha-synuclein transgenic mice
    Christian Freichel
    Pharma Research, F Hoffmann La Roche Ltd, 4070 Basel, Switzerland
    Neurobiol Aging 28:1421-35. 2007
    ..Thus, age-dependent fibrillization of alphaSYN in specific cortical regions concomitant with cognitive decline may reflect dementia with Lewy bodies in a transgenic mouse model...
  22. pmc Oxidative stress in transgenic mice with oligodendroglial alpha-synuclein overexpression replicates the characteristic neuropathology of multiple system atrophy
    Nadia Stefanova
    Clinical Department of Neurology, Innsbruck Medical University, Anichstrasse 35 A 6020, Innsbruck, Austria
    Am J Pathol 166:869-76. 2005
    ..Our results indicate that combined mitochondrial inhibition and overexpression of oligodendroglial alpha-SYN generates a novel model of MSA that may be useful for evaluating both pathogenesis and treatment strategies...
  23. ncbi alpha-Synucleinopathy models and human neuropathology: similarities and differences
    Philipp J Kahle
    Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University Clinics Tübingen, Otfried Muller Strasse 27, 72076, Tubingen, Germany
    Acta Neuropathol 115:87-95. 2008
    ....
  24. ncbi The aggregation of alpha-synuclein is stimulated by FK506 binding proteins as shown by fluorescence correlation spectroscopy
    Melanie Gerard
    Laboratory of Biomolecular Dynamics, K U Leuven, Leuven, Belgium
    FASEB J 20:524-6. 2006
    ..Our results open perspectives for the treatment of PD with immunophilin ligands that inhibit a specific member of the FKBP family...
  25. ncbi Mechanisms and models of alpha-synuclein-related neurodegeneration
    Wolfdieter Springer
    Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University Clinics Tübingen, Otfried Muller Strasse 27, 72076 Tubingen, Germany
    Curr Neurol Neurosci Rep 6:432-6. 2006
    ..These recent findings provided major insights into the molecular mechanisms of alpha-synucleinopathies...