Philip Kahl

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. doi Saturation biopsy improves preoperative Gleason scoring of prostate cancer
    Philip Kahl
    Department of Pathology, University Hospital Bonn Medical School, Sigmund Freud Strasse 25, D 53127 Bonn, Germany
    Pathol Res Pract 205:259-64. 2009
  2. ncbi Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrence
    Philip Kahl
    Institute of Pathology, University Hospital Bonn Medical School, Germany
    Cancer Res 66:11341-7. 2006
  3. ncbi Kaposi's sarcoma of the gastrointestinal tract: report of two cases and review of the literature
    Philip Kahl
    Department of Pathology, University of Bonn Medical School, Sigmund Freud Street 25, 53127 Bonn, Germany
    Pathol Res Pract 203:227-31. 2007
  4. ncbi Orofaciodigital syndrome type IV (Mohr-Majewski syndrome): report of a family with two affected siblings
    Philip Kahl
    Department of Pathology, University of Bonn Medical School, Sigmund Freud Strasse 25, 53127 Bonn, Germany
    Pediatr Dev Pathol 10:239-43. 2007
  5. doi Macroscopic and histopathologic findings in a laparoschisis model in fetal sheep: comparisons with gastroschisis in human fetuses and implications for prenatal interventions
    Philip Kahl
    Department of Pathology, University of Bonn, Sigmund Freud Strasse 25, 53127, Bonn, Germany
    Arch Gynecol Obstet 285:15-9. 2012
  6. doi Global histone H3K27 methylation levels are different in localized and metastatic prostate cancer
    Jörg Ellinger
    Klinik und Poliklinik für Urologie und Kinderurologie, Universitatsklinikum Bonn, Bonn, Germany
    Cancer Invest 30:92-7. 2012
  7. doi Global histone H3 lysine 27 (H3K27) methylation levels and their prognostic relevance in renal cell carcinoma
    Sebastian Rogenhofer
    Department of Urology, University of Bonn, Germany
    BJU Int 109:459-65. 2012
  8. doi Prognostic relevance of global histone H3 lysine 4 (H3K4) methylation in renal cell carcinoma
    Jörg Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Int J Cancer 127:2360-6. 2010
  9. doi CpG island hypermethylation at multiple gene sites in diagnosis and prognosis of prostate cancer
    Jörg Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
    Urology 71:161-7. 2008
  10. pmc Alterations of global histone H4K20 methylation during prostate carcinogenesis
    Turang E Behbahani
    Klinik und Poliklinik für Urologie und Kinderurologie, Universitatsklinikum Bonn, Bonn, Germany
    BMC Urol 12:5. 2012

Collaborators

Detail Information

Publications31

  1. doi Saturation biopsy improves preoperative Gleason scoring of prostate cancer
    Philip Kahl
    Department of Pathology, University Hospital Bonn Medical School, Sigmund Freud Strasse 25, D 53127 Bonn, Germany
    Pathol Res Pract 205:259-64. 2009
    ..Both techniques fail to detect insignificant prostate cancer...
  2. ncbi Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrence
    Philip Kahl
    Institute of Pathology, University Hospital Bonn Medical School, Germany
    Cancer Res 66:11341-7. 2006
    ..Our present study suggests that LSD1 and nuclear FHL2 may serve as novel biomarkers predictive for prostate cancer with aggressive biology and point to a role of LSD1 and FHL2 in constitutive activation of AR-mediated growth signals...
  3. ncbi Kaposi's sarcoma of the gastrointestinal tract: report of two cases and review of the literature
    Philip Kahl
    Department of Pathology, University of Bonn Medical School, Sigmund Freud Street 25, 53127 Bonn, Germany
    Pathol Res Pract 203:227-31. 2007
    ..Nevertheless, Kaposi's sarcoma must always be considered in lesions of the gastrointestinal tract or in gastrointestinal bleeding and should lead to further elucidation of the causes...
  4. ncbi Orofaciodigital syndrome type IV (Mohr-Majewski syndrome): report of a family with two affected siblings
    Philip Kahl
    Department of Pathology, University of Bonn Medical School, Sigmund Freud Strasse 25, 53127 Bonn, Germany
    Pediatr Dev Pathol 10:239-43. 2007
    ..The features of both fetuses showed a transitional phenotype between the OFDS type II (Mohr syndrome) and the short rib-polydactyly syndrome type II (Majewski syndrome), thus extending the known spectrum of the OFDS type IV...
  5. doi Macroscopic and histopathologic findings in a laparoschisis model in fetal sheep: comparisons with gastroschisis in human fetuses and implications for prenatal interventions
    Philip Kahl
    Department of Pathology, University of Bonn, Sigmund Freud Strasse 25, 53127, Bonn, Germany
    Arch Gynecol Obstet 285:15-9. 2012
    ..The purpose of this study was to compare macroscopic and histopathologic characteristics of experimental laparoschisis in sheep fetuses with actual cases of gastroschisis from a postmortem series of human fetuses...
  6. doi Global histone H3K27 methylation levels are different in localized and metastatic prostate cancer
    Jörg Ellinger
    Klinik und Poliklinik für Urologie und Kinderurologie, Universitatsklinikum Bonn, Bonn, Germany
    Cancer Invest 30:92-7. 2012
    ..H3K27 mono-methylation was correlated with pT-stage, capsular penetration, seminal vesicle infiltration, and Gleason score in localized PCA and may therefore indicate adverse prognosis...
  7. doi Global histone H3 lysine 27 (H3K27) methylation levels and their prognostic relevance in renal cell carcinoma
    Sebastian Rogenhofer
    Department of Urology, University of Bonn, Germany
    BJU Int 109:459-65. 2012
    ..To evaluate if histone H3 lysine 27 (H3K27) methylation plays a role in renal cell carcinoma (RCC) tissue and whether its expression is a predictor of cancer recurrence in RCC...
  8. doi Prognostic relevance of global histone H3 lysine 4 (H3K4) methylation in renal cell carcinoma
    Jörg Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Int J Cancer 127:2360-6. 2010
    ..Our study on H3K4 methylation supports the concept of global histone modifications as potential cancer prognosis markers...
  9. doi CpG island hypermethylation at multiple gene sites in diagnosis and prognosis of prostate cancer
    Jörg Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
    Urology 71:161-7. 2008
    ..CpG island hypermethylation causes gene silencing and could be decisive in prostate carcinogenesis and progression. We investigated its role at multiple gene sites during prostate carcinogenesis...
  10. pmc Alterations of global histone H4K20 methylation during prostate carcinogenesis
    Turang E Behbahani
    Klinik und Poliklinik für Urologie und Kinderurologie, Universitatsklinikum Bonn, Bonn, Germany
    BMC Urol 12:5. 2012
    ..Our study was designed to assess global methylation levels of histone 4 lysine 20 (H4K20me1-3) at different stages of prostate cancer (PCA) carcinogenesis...
  11. doi FHL2 expression in peritumoural fibroblasts correlates with lymphatic metastasis in sporadic but not in HNPCC-associated colon cancer
    Lucia Gullotti
    Institute of Pathology, University of Bonn Medical School, Bonn, Germany
    Lab Invest 91:1695-705. 2011
    ..These findings are absent in HNPCC-associated colon cancers in vivo and may contribute to a less invasive and more protruding tumour margin of microsatellite instable carcinomas...
  12. doi Four-and-a-half LIM domain protein 2 is a novel regulator of sphingosine 1-phosphate receptor 1 in CCL19-induced dendritic cell migration
    Katharina König
    Institute of Pathology, University Hospital Bonn, Sigmund Freud Strasse 25, Bonn 53127, Germany
    J Immunol 185:1466-75. 2010
    ..Our results identify FHL2 as an important novel regulator of DC migration via regulation of their sensitivity toward environmental migratory cues like S1P and CCL19...
  13. doi Transient perioperative pharmacologic inhibition of muscularis macrophages as a target for prophylaxis of postoperative ileus does not affect anastomotic healing in mice
    Dimitrios Pantelis
    Department of Surgery, University of Bonn, Bonn, Germany
    Surgery 148:59-70. 2010
    ..The aim of this study was to investigate whether pharmacologic or genetic depletion of these inflammatory cells influences anastomotic healing...
  14. doi Apoptotic DNA fragments in serum of patients with muscle invasive bladder cancer: a prognostic entity
    Jörg Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Cancer Lett 264:274-80. 2008
    ..011) indicating that the AI is an independent prognostic factor. Thus, cell-free DNA seems to be a useful prognostic marker in patients with BCA...
  15. doi Global levels of histone modifications predict prostate cancer recurrence
    Jörg Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Bonn, Germany
    Prostate 70:61-9. 2010
    ..Our study was performed to evaluate histone lysine (H(x)K(y)) and histone acetyl (H(x)Ac) modifications in prostate tissue...
  16. pmc Loss of the keratin cytoskeleton is not sufficient to induce epithelial mesenchymal transition in a novel KRAS driven sporadic lung cancer mouse model
    Katharina König
    Institute of Pathology, University of Cologne, Cologne, Germany
    PLoS ONE 8:e57996. 2013
    ..Thus, we conclude that loss of the keratin cytoskeleton per se is not sufficient to causally drive EMT in this tumor model...
  17. doi Histone methylation defines an epigenetic entity in penile squamous cell carcinoma
    Sebastian Rogenhofer
    Klinik und Poliklinik für Urologie und Kinderurologie, Universitatsklinikum Bonn, Bonn, Germany
    J Urol 189:1117-22. 2013
    ..Histone methylation patterns are frequently altered during carcinogenesis. Therefore, we investigated the methylation pattern of the histones H3K4, H3K9 and H3K27 in penile carcinoma and normal tissue...
  18. doi Is there a therapeutic role for fetoscopic surgery in the prenatal treatment of gastroschisis? A feasibility study in sheep
    Thomas Kohl
    Department of Obstetrics and Prenatal Medicine, German Center for Fetal Surgery and Minimally Invasive Therapy, University Hospital Bonn Medical School, Bonn, Germany
    Surg Endosc 23:1499-505. 2009
    ..The purpose of this study was to evaluate a potential role for fetoscopic surgery in severely affected fetuses with this condition...
  19. ncbi Decreased levels of histone H3K9me1 indicate poor prognosis in patients with renal cell carcinoma
    Sebastian Rogenhofer
    Department of Urology, University Hospital Bonn, Bonn, Germany
    Anticancer Res 32:879-86. 2012
    ..To determine the role of global histone H3K9 and H4K20 methylation levels as prognostic parameters in patients with renal cell cancer (RCC)...
  20. doi DNA hypermethylation in papillary renal cell carcinoma
    Jörg Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Bonn, Germany
    BJU Int 107:664-9. 2011
    ..To investigate the pattern of DNA CpG island hypermethylation in papillary renal cell carcinoma (pRCC)...
  21. doi Global histone acetylation levels: prognostic relevance in patients with renal cell carcinoma
    Davit Mosashvilli
    Department of Urology, University Hospital Bonn, Bonn, Germany
    Cancer Sci 101:2664-9. 2010
    ..In conclusion, our study supports the concept of global histone modification levels as a universal cancer prognosis marker, and provides evidence for the use of histone deacetylases inhibitors as future drugs in the therapy of RCC...
  22. doi Impaired intestinal wound healing in Fhl2-deficient mice is due to disturbed collagen metabolism
    Jutta Kirfel
    Institute of Pathology, University Hospital Medical School, Sigmund Freud Str 25, D 53127 Bonn, Germany
    Exp Cell Res 314:3684-91. 2008
    ....
  23. doi Epidermal growth factor receptor mutations in non-small cell lung cancer influence downstream Akt, MAPK and Stat3 signaling
    Sebastian Zimmer
    Institute of Pathology, University Hospital Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    J Cancer Res Clin Oncol 135:723-30. 2009
    ..So far these mutations have been extensively characterized in established cell lines. The aim of this study was to determine the effects of EGFR mutations on downstream signaling in human tumor specimens...
  24. doi Oral CPSI-2364 Treatment Prevents Postoperative Ileus in Swine without Impairment of Anastomotic Healing
    Tim O Vilz
    Department of Surgery, University of Bonn, Bonn, Germany
    Cell Physiol Biochem 32:1362-73. 2013
    ..Subsumed, an oral preoperative administration of CPSI-2364 appears to be a safe and efficient strategy for prophylaxis of POI. © 2013 S. Karger AG, Basel. ..
  25. doi The effect of sealing with a fixed combination of collagen matrix-bound coagulation factors on the healing of colonic anastomoses in experimental high-risk mice models
    Dimitrios Pantelis
    Department of Surgery, Division of Transplant and Hepatobiliary Surgery, Rheinische Friedrich Wilhelms University Bonn, Sigmund Freud Str 25, 53105, Bonn, Germany
    Langenbecks Arch Surg 395:1039-48. 2010
    ....
  26. ncbi Hypermethylation of cell-free serum DNA indicates worse outcome in patients with bladder cancer
    Jörg Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Germany
    J Urol 179:346-52. 2008
    ..CpG island hypermethylation is a frequent event in bladder carcinogenesis and progression. We investigated the diagnostic and prognostic value of hypermethylation in cell-free serum DNA of patients with bladder cancer...
  27. ncbi Prognostic value of CpG island hypermethylation at PTGS2, RAR-beta, EDNRB, and other gene loci in patients undergoing radical prostatectomy
    Patrick J Bastian
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Germany
    Eur Urol 51:665-74; discussion 674. 2007
    ....
  28. doi Mutation and association analyses of the candidate genes ESR1, ESR2, MAX, PCNA, and KAT2A in patients with unexplained MSH2-deficient tumors
    Nils Rahner
    Institute of Human Genetics, BMZ, University of Bonn, Sigmund Freud Strasse 25, 53127, Bonn, Germany
    Fam Cancer 11:19-26. 2012
    ..The present results suggest that neither rare nor common genetic variants in ESR1, ESR2, MAX, PCNA, or KAT2A contribute to the development of Lynch syndrome...
  29. ncbi CpG island hypermethylation in cell-free serum DNA identifies patients with localized prostate cancer
    Jörg Ellinger
    Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
    Prostate 68:42-9. 2008
    ..Our aim was to analyze the diagnostic and prognostic possibilities of multigene methylation analysis in cell-free serum DNA of prostate cancer (PCA) patients...
  30. doi Hepatocarcinogenesis in non-cirrhotic liver is associated with a reduced number of clonal hepatocellular patches in non-tumorous liver parenchyma
    Alexander C Adam
    Department of Pathology, University of Cologne, Germany
    J Pathol 228:333-40. 2012
    ..The analogy to ageing-related changes is suggestive of premature ageing of stem cells in non-cirrhotic hepatocellular carcinoma-bearing liver as an early step to hepatocarcinogenesis...
  31. pmc Optimization of quantitative MGMT promoter methylation analysis using pyrosequencing and combined bisulfite restriction analysis
    Thomas Mikeska
    Department of Neuropathology, University of Bonn Medical Center, Sigmund Freud Str 25, D 53105 Bonn, Germany
    J Mol Diagn 9:368-81. 2007
    ..The optimized pyrosequencing assay performed best and provides a sensitive, robust, and easy-to-use method for quantitative assessment of MGMT methylation, for both snap-frozen and paraffin-embedded specimens...