Research Topics
Genomes and Genes | Philip KahlSummaryAffiliation: University of Bonn Country: Germany Publications
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Publications
Saturation biopsy improves preoperative Gleason scoring of prostate cancerPhilip Kahl
Department of Pathology, University Hospital Bonn Medical School, Sigmund Freud Strasse 25, D 53127 Bonn, Germany
Pathol Res Pract 205:259-64. 2009..Both techniques fail to detect insignificant prostate cancer...
Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrencePhilip Kahl
Institute of Pathology, University Hospital Bonn Medical School, Germany
Cancer Res 66:11341-7. 2006..Our present study suggests that LSD1 and nuclear FHL2 may serve as novel biomarkers predictive for prostate cancer with aggressive biology and point to a role of LSD1 and FHL2 in constitutive activation of AR-mediated growth signals...- Kaposi's sarcoma of the gastrointestinal tract: report of two cases and review of the literaturePhilip Kahl
Department of Pathology, University of Bonn Medical School, Sigmund Freud Street 25, 53127 Bonn, Germany
Pathol Res Pract 203:227-31. 2007..Nevertheless, Kaposi's sarcoma must always be considered in lesions of the gastrointestinal tract or in gastrointestinal bleeding and should lead to further elucidation of the causes... - Orofaciodigital syndrome type IV (Mohr-Majewski syndrome): report of a family with two affected siblingsPhilip Kahl
Department of Pathology, University of Bonn Medical School, Sigmund Freud Strasse 25, 53127 Bonn, Germany
Pediatr Dev Pathol 10:239-43. 2007..The features of both fetuses showed a transitional phenotype between the OFDS type II (Mohr syndrome) and the short rib-polydactyly syndrome type II (Majewski syndrome), thus extending the known spectrum of the OFDS type IV... - Macroscopic and histopathologic findings in a laparoschisis model in fetal sheep: comparisons with gastroschisis in human fetuses and implications for prenatal interventionsPhilip Kahl
Department of Pathology, University of Bonn, Sigmund Freud Strasse 25, 53127, Bonn, Germany
Arch Gynecol Obstet 285:15-9. 2012..The purpose of this study was to compare macroscopic and histopathologic characteristics of experimental laparoschisis in sheep fetuses with actual cases of gastroschisis from a postmortem series of human fetuses... - Global histone H3K27 methylation levels are different in localized and metastatic prostate cancerJörg Ellinger
Klinik und Poliklinik für Urologie und Kinderurologie, Universitatsklinikum Bonn, Bonn, Germany
Cancer Invest 30:92-7. 2012..H3K27 mono-methylation was correlated with pT-stage, capsular penetration, seminal vesicle infiltration, and Gleason score in localized PCA and may therefore indicate adverse prognosis... - Global histone H3 lysine 27 (H3K27) methylation levels and their prognostic relevance in renal cell carcinomaSebastian Rogenhofer
Department of Urology, University of Bonn, Germany
BJU Int 109:459-65. 2012..To evaluate if histone H3 lysine 27 (H3K27) methylation plays a role in renal cell carcinoma (RCC) tissue and whether its expression is a predictor of cancer recurrence in RCC... - CpG island hypermethylation at multiple gene sites in diagnosis and prognosis of prostate cancerJörg Ellinger
Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
Urology 71:161-7. 2008..CpG island hypermethylation causes gene silencing and could be decisive in prostate carcinogenesis and progression. We investigated its role at multiple gene sites during prostate carcinogenesis... - Prognostic relevance of global histone H3 lysine 4 (H3K4) methylation in renal cell carcinomaJörg Ellinger
Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Int J Cancer 127:2360-6. 2010..Our study on H3K4 methylation supports the concept of global histone modifications as potential cancer prognosis markers... 
Alterations of global histone H4K20 methylation during prostate carcinogenesisTurang E Behbahani
Klinik und Poliklinik für Urologie und Kinderurologie, Universitatsklinikum Bonn, Bonn, Germany
BMC Urol 12:5. 2012..Our study was designed to assess global methylation levels of histone 4 lysine 20 (H4K20me1-3) at different stages of prostate cancer (PCA) carcinogenesis...- FHL2 expression in peritumoural fibroblasts correlates with lymphatic metastasis in sporadic but not in HNPCC-associated colon cancerLucia Gullotti
Institute of Pathology, University of Bonn Medical School, Bonn, Germany
Lab Invest 91:1695-705. 2011..These findings are absent in HNPCC-associated colon cancers in vivo and may contribute to a less invasive and more protruding tumour margin of microsatellite instable carcinomas... - Four-and-a-half LIM domain protein 2 is a novel regulator of sphingosine 1-phosphate receptor 1 in CCL19-induced dendritic cell migrationKatharina König
Institute of Pathology, University Hospital Bonn, Sigmund Freud Strasse 25, Bonn 53127, Germany
J Immunol 185:1466-75. 2010..Our results identify FHL2 as an important novel regulator of DC migration via regulation of their sensitivity toward environmental migratory cues like S1P and CCL19... - Transient perioperative pharmacologic inhibition of muscularis macrophages as a target for prophylaxis of postoperative ileus does not affect anastomotic healing in miceDimitrios Pantelis
Department of Surgery, University of Bonn, Bonn, Germany
Surgery 148:59-70. 2010..The aim of this study was to investigate whether pharmacologic or genetic depletion of these inflammatory cells influences anastomotic healing... - Apoptotic DNA fragments in serum of patients with muscle invasive bladder cancer: a prognostic entityJörg Ellinger
Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Cancer Lett 264:274-80. 2008..011) indicating that the AI is an independent prognostic factor. Thus, cell-free DNA seems to be a useful prognostic marker in patients with BCA... - Global levels of histone modifications predict prostate cancer recurrenceJörg Ellinger
Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Bonn, Germany
Prostate 70:61-9. 2010..Our study was performed to evaluate histone lysine (H(x)K(y)) and histone acetyl (H(x)Ac) modifications in prostate tissue... - Decreased levels of histone H3K9me1 indicate poor prognosis in patients with renal cell carcinomaSebastian Rogenhofer
Department of Urology, University Hospital Bonn, Bonn, Germany
Anticancer Res 32:879-86. 2012..To determine the role of global histone H3K9 and H4K20 methylation levels as prognostic parameters in patients with renal cell cancer (RCC)... - Is there a therapeutic role for fetoscopic surgery in the prenatal treatment of gastroschisis? A feasibility study in sheepThomas Kohl
Department of Obstetrics and Prenatal Medicine, German Center for Fetal Surgery and Minimally Invasive Therapy, University Hospital Bonn Medical School, Bonn, Germany
Surg Endosc 23:1499-505. 2009..The purpose of this study was to evaluate a potential role for fetoscopic surgery in severely affected fetuses with this condition... - Global histone acetylation levels: prognostic relevance in patients with renal cell carcinomaDavit Mosashvilli
Department of Urology, University Hospital Bonn, Bonn, Germany
Cancer Sci 101:2664-9. 2010..In conclusion, our study supports the concept of global histone modification levels as a universal cancer prognosis marker, and provides evidence for the use of histone deacetylases inhibitors as future drugs in the therapy of RCC... - DNA hypermethylation in papillary renal cell carcinomaJörg Ellinger
Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Bonn, Germany
BJU Int 107:664-9. 2011..To investigate the pattern of DNA CpG island hypermethylation in papillary renal cell carcinoma (pRCC)... - Impaired intestinal wound healing in Fhl2-deficient mice is due to disturbed collagen metabolismJutta Kirfel
Institute of Pathology, University Hospital Medical School, Sigmund Freud Str 25, D 53127 Bonn, Germany
Exp Cell Res 314:3684-91. 2008.... - Epidermal growth factor receptor mutations in non-small cell lung cancer influence downstream Akt, MAPK and Stat3 signalingSebastian Zimmer
Institute of Pathology, University Hospital Bonn, Sigmund Freud Strasse 25, Bonn, Germany
J Cancer Res Clin Oncol 135:723-30. 2009..So far these mutations have been extensively characterized in established cell lines. The aim of this study was to determine the effects of EGFR mutations on downstream signaling in human tumor specimens... - The effect of sealing with a fixed combination of collagen matrix-bound coagulation factors on the healing of colonic anastomoses in experimental high-risk mice modelsDimitrios Pantelis
Department of Surgery, Division of Transplant and Hepatobiliary Surgery, Rheinische Friedrich Wilhelms University Bonn, Sigmund Freud Str 25, 53105, Bonn, Germany
Langenbecks Arch Surg 395:1039-48. 2010.... - Prognostic value of CpG island hypermethylation at PTGS2, RAR-beta, EDNRB, and other gene loci in patients undergoing radical prostatectomyPatrick J Bastian
Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Germany
Eur Urol 51:665-74; discussion 674. 2007.... - Hypermethylation of cell-free serum DNA indicates worse outcome in patients with bladder cancerJörg Ellinger
Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Germany
J Urol 179:346-52. 2008..CpG island hypermethylation is a frequent event in bladder carcinogenesis and progression. We investigated the diagnostic and prognostic value of hypermethylation in cell-free serum DNA of patients with bladder cancer... - Mutation and association analyses of the candidate genes ESR1, ESR2, MAX, PCNA, and KAT2A in patients with unexplained MSH2-deficient tumorsNils Rahner
Institute of Human Genetics, BMZ, University of Bonn, Sigmund Freud Strasse 25, 53127, Bonn, Germany
Fam Cancer 11:19-26. 2012..The present results suggest that neither rare nor common genetic variants in ESR1, ESR2, MAX, PCNA, or KAT2A contribute to the development of Lynch syndrome... - CpG island hypermethylation in cell-free serum DNA identifies patients with localized prostate cancerJörg Ellinger
Klinik und Poliklinik fur Urologie, Universitatsklinikum Bonn, Rheinische Friedrich Wilhelms Universitat Bonn, Bonn, Germany
Prostate 68:42-9. 2008..Our aim was to analyze the diagnostic and prognostic possibilities of multigene methylation analysis in cell-free serum DNA of prostate cancer (PCA) patients... - Hepatocarcinogenesis in non-cirrhotic liver is associated with a reduced number of clonal hepatocellular patches in non-tumorous liver parenchymaAlexander C Adam
Department of Pathology, University of Cologne, Germany
J Pathol 228:333-40. 2012..Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd... - Optimization of quantitative MGMT promoter methylation analysis using pyrosequencing and combined bisulfite restriction analysisThomas Mikeska
Department of Neuropathology, University of Bonn Medical Center, Sigmund Freud Str 25, D 53105 Bonn, Germany
J Mol Diagn 9:368-81. 2007..The optimized pyrosequencing assay performed best and provides a sensitive, robust, and easy-to-use method for quantitative assessment of MGMT methylation, for both snap-frozen and paraffin-embedded specimens...