Christian Junghanss

Summary

Affiliation: University of Rostock
Country: Germany

Publications

  1. ncbi request reprint Incidence and outcome of bacterial and fungal infections following nonmyeloablative compared with myeloablative allogeneic hematopoietic stem cell transplantation: a matched control study
    Christian Junghanss
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Biol Blood Marrow Transplant 8:512-20. 2002
  2. ncbi request reprint Multivariate analyses of prognostic factors in acute myeloid leukemia: relevance of cytogenetic abnormalities and CD34 expression
    C Junghanss
    Department of Internal Medicine, Division of Hematology and Oncology, University of Rostock, 18057 Rostock, Germany
    Neoplasma 52:402-10. 2005
  3. pmc The novel arylindolylmaleimide PDA-66 displays pronounced antiproliferative effects in acute lymphoblastic leukemia cells
    Christin Kretzschmar
    Department of Hematology Oncology Palliative Medicine, Division of Medicine, University of Rostock, Ernst Heydemann Str, 6, Rostock 18057, Germany
    BMC Cancer 14:71. 2014
  4. ncbi request reprint Distribution changes of epithelial dendritic cells in canine cornea and mucous membranes related to hematopoietic stem cell transplantation
    Doreen Killian
    University of Rostock, Division of Medicine, Department of Hematology, Oncology and Palliative Medicine, Ernst Heydemann Str 6, 18057 Rostock, Germany
    In Vivo 27:761-71. 2013
  5. ncbi request reprint MicroRNA 181a influences the expression of HMGB1 and CD4 in acute Leukemias
    Meike Dahlhaus
    University of Rostock, Division of Medicine, Department of Hematology Oncology Palliative Medicine, Ernst Heydemann Str 6, 18057 Rostock, Germany
    Anticancer Res 33:445-52. 2013
  6. doi request reprint Everolimus in combination with cyclosporin a as pre- and posttransplantation immunosuppressive therapy in nonmyeloablative allogeneic hematopoietic stem cell transplantation
    Christian Junghanss
    Department of Internal Medicine, Medical Clinic III Hematology, Oncology, Palliative Medicine, University of Rostock, Ernst Heydemann Strasse 6, Rostock, Germany
    Biol Blood Marrow Transplant 18:1061-8. 2012
  7. ncbi request reprint Cytomegalovirus infections following chemotherapies of the newer generation
    Christian Junghanss
    Division of Hematology and Oncology, Department of Internal Medicine, University of Rostock, Rostock, Germany
    Haematologica 90:1591. 2005
  8. pmc Investigation of immunological approaches to enhance engraftment in a 1 Gy TBI canine hematopoietic stem cell transplantation model
    Sandra Lange
    Division of Haematology Oncology, Department of Medicine, University of Rostock, Rostock, Germany
    Exp Hematol 37:143-50. 2009
  9. doi request reprint Upfront denileukin diftitox as in vivo regulatory T-cell depletion in order to enhance vaccination effects in a canine allogeneic hematopoietic stem cell transplantation model
    Anne Knueppel
    Hematology Oncology Palliative Medicine, University of Rostock, Ernst Heydemann Strasse 6, 18057 Rostock, Germany
    Vet Immunol Immunopathol 145:233-40. 2012
  10. ncbi request reprint The dual kinase inhibitor NVP-BEZ235 in combination with cytotoxic drugs exerts anti-proliferative activity towards acute lymphoblastic leukemia cells
    Catrin Schult
    University of Rostock, Division of Medicine, Department of Hematology, Oncology and Palliative Medicine, Ernst Heydemann Str 6, 18057 Rostock, Germany
    Anticancer Res 32:463-74. 2012

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Incidence and outcome of bacterial and fungal infections following nonmyeloablative compared with myeloablative allogeneic hematopoietic stem cell transplantation: a matched control study
    Christian Junghanss
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Biol Blood Marrow Transplant 8:512-20. 2002
    ..This risk is an important consideration for the future development of preventive strategies...
  2. ncbi request reprint Multivariate analyses of prognostic factors in acute myeloid leukemia: relevance of cytogenetic abnormalities and CD34 expression
    C Junghanss
    Department of Internal Medicine, Division of Hematology and Oncology, University of Rostock, 18057 Rostock, Germany
    Neoplasma 52:402-10. 2005
    ..In conclusion, karyotype and CD34 expression are independent prognostic markers in newly diagnosed AML. Furthermore, receiving an allogeneic HSCT at some point of the treatment course seems to be of benefit for AML patients...
  3. pmc The novel arylindolylmaleimide PDA-66 displays pronounced antiproliferative effects in acute lymphoblastic leukemia cells
    Christin Kretzschmar
    Department of Hematology Oncology Palliative Medicine, Division of Medicine, University of Rostock, Ernst Heydemann Str, 6, Rostock 18057, Germany
    BMC Cancer 14:71. 2014
    ..Herein, we evaluated the influence of a novel arylindolylmaleimide (PDA-66), a potential GSK3β inhibitor, on several ALL cell lines...
  4. ncbi request reprint Distribution changes of epithelial dendritic cells in canine cornea and mucous membranes related to hematopoietic stem cell transplantation
    Doreen Killian
    University of Rostock, Division of Medicine, Department of Hematology, Oncology and Palliative Medicine, Ernst Heydemann Str 6, 18057 Rostock, Germany
    In Vivo 27:761-71. 2013
    ..We screened for DC frequency in the cornea and oral mucous membranes after HSCT by confocal laser scanning microscopy (CLSM) in a canine model...
  5. ncbi request reprint MicroRNA 181a influences the expression of HMGB1 and CD4 in acute Leukemias
    Meike Dahlhaus
    University of Rostock, Division of Medicine, Department of Hematology Oncology Palliative Medicine, Ernst Heydemann Str 6, 18057 Rostock, Germany
    Anticancer Res 33:445-52. 2013
    ..Overexpression of miR-181a in AML cells led to a significant decrease in cell proliferation and metabolic activity. The present data indicate a possible role of this specific miRNA in immunogenicity...
  6. doi request reprint Everolimus in combination with cyclosporin a as pre- and posttransplantation immunosuppressive therapy in nonmyeloablative allogeneic hematopoietic stem cell transplantation
    Christian Junghanss
    Department of Internal Medicine, Medical Clinic III Hematology, Oncology, Palliative Medicine, University of Rostock, Ernst Heydemann Strasse 6, Rostock, Germany
    Biol Blood Marrow Transplant 18:1061-8. 2012
    ..Hence, our study does not support the application of RAD001/CsA as standard practice in this setting...
  7. ncbi request reprint Cytomegalovirus infections following chemotherapies of the newer generation
    Christian Junghanss
    Division of Hematology and Oncology, Department of Internal Medicine, University of Rostock, Rostock, Germany
    Haematologica 90:1591. 2005
  8. pmc Investigation of immunological approaches to enhance engraftment in a 1 Gy TBI canine hematopoietic stem cell transplantation model
    Sandra Lange
    Division of Haematology Oncology, Department of Medicine, University of Rostock, Rostock, Germany
    Exp Hematol 37:143-50. 2009
    ..We investigated whether postgrafting stimulation of donor T cells against recipient's hematopoietic antigens or graft augmentation with donor monocyte-derived dendritic cells (MoDC) promote engraftment following 1 Gy TBI...
  9. doi request reprint Upfront denileukin diftitox as in vivo regulatory T-cell depletion in order to enhance vaccination effects in a canine allogeneic hematopoietic stem cell transplantation model
    Anne Knueppel
    Hematology Oncology Palliative Medicine, University of Rostock, Ernst Heydemann Strasse 6, 18057 Rostock, Germany
    Vet Immunol Immunopathol 145:233-40. 2012
    ..This effect could not be confirmed in vivo even if the immune system was stimulated by vaccinations...
  10. ncbi request reprint The dual kinase inhibitor NVP-BEZ235 in combination with cytotoxic drugs exerts anti-proliferative activity towards acute lymphoblastic leukemia cells
    Catrin Schult
    University of Rostock, Division of Medicine, Department of Hematology, Oncology and Palliative Medicine, Ernst Heydemann Str 6, 18057 Rostock, Germany
    Anticancer Res 32:463-74. 2012
    ..Here, we examined the activity of NVP-BEZ235 in acute lymphoblastic leukemia (ALL) cells and the best modalities for combination approaches...
  11. ncbi request reprint Phenotypic and functional characterization of freshly isolated and expanded canine regulatory T cells
    Anne Knueppel
    Division of Medicine, Department of Hematology Oncology Palliative Care, University of Rostock, Ernst Heydemann Strasse, 18055 Rostock, Germany
    Exp Anim 60:471-9. 2011
    ..Enrichment and expansion of canine T(reg) is feasible, and canine T(reg) had similar characteristics to T(reg) from other species...
  12. ncbi request reprint Chronic graft versus host disease but not the intensity of conditioning has impact on survival after allogeneic hematopoietic stem cell transplantation for advanced hematological diseases
    Inken Hilgendorf
    Department of Hematology, Oncology, Palliative Care, University of Rostock, Germany
    Onkologie 35:487-92. 2012
    ..Allogeneic hematopoietic stem cell transplantation (alloHSCT) is often performed in cases of advanced hematological diseases, but because of the associated mortality and a high risk of relapse it is life prolonging only in some patients...
  13. doi request reprint Validation of the grip test and human activity profile for evaluation of physical performance during the intermediate phase after allogeneic hematopoietic stem cell transplantation
    Maxi Kramer
    Department of Hematology, Oncology and Palliative Care, University of Rostock, Rostock, Germany
    Support Care Cancer 21:1121-9. 2013
    ..The aims of the presented study were to validate tools evaluating physical functioning (PF) after allogeneic hematopoietic stem cell transplantation (alloHSCT) and to analyze the impact of the clinical course on PF...
  14. ncbi request reprint Interference of a novel indolylmaleimide with microtubules induces mitotic arrest and apoptosis in human progenitor and cancer cells
    Christian Eisenlöffel
    Albrecht Kossel Institute for Neuroregeneration, Center for Mental Health, University of Rostock, Germany
    Biochem Pharmacol 85:763-71. 2013
    ..Thus PDA-66 is a new anti-mitotic compound with an indole-core with the potential to be used for cancer therapy...
  15. doi request reprint Enteral budesonide in treatment for mild and moderate gastrointestinal chronic GVHD
    H Andree
    Department of Hematology and Oncology, University of Rostock, Rostock, Germany
    Bone Marrow Transplant 42:541-6. 2008
    ..BUD represents a treatment option in mild-to-moderate cGVHD, which is well tolerated and associated with a high response rate in gastrointestinal cGVHD...
  16. doi request reprint Neurological complications after intrathecal liposomal cytarabine application in patients after allogeneic haematopoietic stem cell transplantation
    Inken Hilgendorf
    Department of Internal Medicine, Division of Haematology and Oncology, University of Rostock, Ernst Heydemann Str 6, 18057, Rostock, Germany
    Ann Hematol 87:1009-12. 2008
    ..The feasibility and safety of liposomal cytarabine in HSCT recipients has to be evaluated in a prospective study...
  17. doi request reprint Azacitidine in patients with acute myeloid leukemia medically unfit for or resistant to chemotherapy: a multicenter phase I/II study
    Haifa K Al-Ali
    Department of Hematology Oncology, University of Leipzig, Leipzig, Germany
    Leuk Lymphoma 53:110-7. 2012
    ..05). Lower marrow blasts on day 15 of cycle 1, irrespective of pretreatment count, predicted subsequent response (p = 0.01). Azacitidine is active and well tolerated in elderly patients with newly diagnosed AML...
  18. doi request reprint Multimodal therapy for localized spinal epidural follicular lymphoma
    Christoph Kahl
    Department of Internal Medicine, Division of Hematology and Oncology, University of Rostock, Germany
    Onkologie 33:381-4. 2010
    ..An epidural growth of low-grade lymphoma is even more unusual. Due to this low incidence, therapeutic experience for this entity is limited...
  19. pmc Systems biologists seek fuller integration of systems biology approaches in new cancer research programs
    Olaf Wolkenhauer
    University of Rostock, Rostock, Germany
    Cancer Res 70:12-3. 2010
    ....
  20. ncbi request reprint Treatment of steroid-resistant acute graft-versus-host disease with daclizumab and etanercept
    D Wolff
    Division of Haematology and Oncology, Department of Internal Medicine, University of Rostock, Germany
    Bone Marrow Transplant 35:1003-10. 2005
    ..Nevertheless, long-term mortality due to infectious complications and chronic GVHD remains high...
  21. ncbi request reprint Treatment with campath-1H for relapsed chronic lymphocytic leukemia after allogeneic peripheral blood stem cell transplantation does not abrogate the development of chronic GVHD
    Daniel Wolff
    Division of Haematology and Oncology, Department of Internal Medicine, University of Rostock, Germany
    Eur J Haematol 72:145-8. 2004
    ..Furthermore, the GVL effect was not abrogated by the use of campath-1H...
  22. ncbi request reprint [Allogeneic blood stem cell transplantation in high-risk patients after conditioning with treosulfan and fludarabine]
    J Casper
    Abteilung Hämatologie und Onkologie der Medizinischen Fakultät der Universität Rostock
    Dtsch Med Wochenschr 130:2125-9. 2005
    ..We have, therefore, developed a dose intense but toxicity reduced conditioning regimen based on treosulfan and fludarabine and report first results...
  23. doi request reprint [Pancytopenia and lymph node swelling. Cardinal symptoms of an unusual differential diagnosis]
    C Kahl
    Abteilung Hämatologie und Onkologie, Klinik und Poliklinik für Innere Medizin, Ernst Heydemann Strasse 6, 18055 Rostock
    Internist (Berl) 50:734-9. 2009
    ..This therapy resulted in normalization of the blood counts. Anitibody levels and the EBV genome levels became negative...
  24. doi request reprint Invasive zygomycosis in patients with graft-versus-host disease after allogeneic stem cell transplantation
    M Leithauser
    Department of Medicine, Division of Hematology Oncology, University of Rostock, Rostock, Germany
    Transpl Infect Dis 12:251-7. 2010
    ..Despite effective antifungals and surgical intervention, the prognosis is grim in patients with active GVHD, as immunoreconstitution is mandatory for successful management...
  25. ncbi request reprint Replacement of calcineurin inhibitors with daclizumab in patients with transplantation-associated microangiopathy or renal insufficiency associated with graft-versus-host disease
    D Wolff
    Department of Haematology and Oncology, University of Rostock, Rostock, Germany
    Bone Marrow Transplant 38:445-51. 2006
    ..Our data demonstrate that replacement of CI by daclizumab can improve TAM and RI. However, mortality remains high in patients with acute GVHD...
  26. pmc The multikinase inhibitor Sorafenib displays significant antiproliferative effects and induces apoptosis via caspase 3, 7 and PARP in B- and T-lymphoblastic cells
    Catrin Schult
    University of Rostock, Division of Medicine, Department of Hematology Oncology, Rostock, Germany
    BMC Cancer 10:560. 2010
    ..The multikinase inhibitor Sorafenib has antitumor activity in solid tumors and its effects on acute lymphoblastic leukemia (ALL) cells are still unclear...
  27. ncbi request reprint Methotrexate-albumin and aminopterin-albumin effectively prevent experimental acute graft-versus-host disease
    Daniel Wolff
    Division of Hematology and Oncology, University of Rostock, Rostock, Germany
    Transplantation 82:527-33. 2006
    ..We explored the activity of two antifolates methotrexate (MTX) and aminopterin (AMPT) bound to HSA in prophylaxis and treatment of experimental acute graft-versus-host disease (aGVHD)...
  28. ncbi request reprint Pharmacokinetics of oral mycophenolate mofetil in combination with CsA in dogs after nonmyeloablative allogeneic hematopoietic stem cell transplantation
    S Lange
    Department of Hematology Oncology, Division of Medicine, University of Rostock, Rostock, Germany
    Bone Marrow Transplant 41:667-74. 2008
    ..Toxicities did not permit single doses higher than 30 mg/kg. Thus, if larger AUCs are desired in order to assure sufficient immunosuppression in HSCT, MMF might have to be administered at least three times daily...
  29. ncbi request reprint Infectious risks and outcomes after stem cell transplantation: are nonmyeloablative transplants changing the picture?
    Christian Junghanss
    Department of Medicine, University of Rostock, School of Medicine, Rostock, Germany
    Curr Opin Infect Dis 15:347-53. 2002
    ..This review summarizes the infectious risks associated with each type of hematopoietic stem cell transplantation conditioning regimen, and presents the results of early clinical studies...
  30. doi request reprint High Mobility Group Box 1-Protein expression in canine haematopoietic cells and influence on canine peripheral blood mononuclear cell proliferative activity
    S Altmann
    Division of Medicine, Department of Haematology Oncology, University of Rostock, Ernst Heydemann Str 6, 18057 Rostock, Germany
    Vet Immunol Immunopathol 126:367-72. 2008
    ..However, in higher concentrations HMGB1 lost its stimulative effect. In conclusion, HMGB1 is broadly expressed in canine haematopoietic cells with highest levels in haematopoietic stem cells. HMGB1 induced directly PBMC proliferation...
  31. ncbi request reprint Canine haematopoietic chimerism analyses by semiquantitative fluorescence detection of variable number of tandem repeat polymorphism
    I Hilgendorf
    Division of Hematology Oncology, Department of Medicine, University of Rostock, Ernst Heydemann Str 6, 18057 Rostock, Germany
    Vet Res Commun 29:103-10. 2005
    ..The method described provides an accurate assessment of haematopoietic chimerism in the canine model with significantly reduced hands-on time compared to conventional gel electrophoresis...
  32. ncbi request reprint Impact of unrelated donor status on the incidence and outcome of cytomegalovirus infections after non-myeloablative allogeneic stem cell transplantation
    Christian Junghanss
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Br J Haematol 123:662-70. 2003
    ....
  33. ncbi request reprint Incidence and outcome of cytomegalovirus infections following nonmyeloablative compared with myeloablative allogeneic stem cell transplantation, a matched control study
    Christian Junghanss
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109 1024, USA
    Blood 99:1978-85. 2002
    ..Therefore, nonmyeloablative HSCT patients should receive CMV surveillance beyond day 100 and pre-emptive ganciclovir treatment similar to that of myeloablative HSCT patients...
  34. ncbi request reprint Diagnosis and treatment of documented infections in neutropenic patients--recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO)
    Dieter Buchheidt
    III Medizinische Klinik, Universitatsklinikum Mannheim, Ruprecht Karls Universitat Heidelberg, Wiesbadener Strasse 7 11, 68305, Mannheim, Germany
    Ann Hematol 82:S127-32. 2003
    ..The response rate is significantly lower in documented infections than in fever of unknown origin (FUO). Evidence-based recommendations for diagnosis and treatment procedures are presented, reflecting study results and expert opinions...
  35. ncbi request reprint Adoptive immunotherapy against kidney targets in dog-leukocyte antigen-identical mixed hematopoietic canine chimeras
    Christian Junghanss
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Transplantation 75:268-74. 2003
    ..Whether sensitization against tissue of solid organs leads to organ-specific immunity that can be transferred by DLI was unknown and was investigated in these experiments using the kidney as target...
  36. doi request reprint Sirolimus in combination with tacrolimus in allogeneic stem cell transplantation--timing and conditioning regimen may be crucial
    Daniel Wolff
    Biol Blood Marrow Transplant 14:942-3. 2008
  37. ncbi request reprint An open-label randomized trial comparing itraconazole oral solution with fluconazole oral solution for primary prophylaxis of fungal infections in patients with haematological malignancy and profound neutropenia
    Axel Glasmacher
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    J Antimicrob Chemother 57:317-25. 2006
    ..This trial studied the efficacy and safety of itraconazole and fluconazole in the prevention of invasive fungal infections in neutropenic patients with haematological malignancies...
  38. ncbi request reprint Tolerance to vascularized kidney grafts in canine mixed hematopoietic chimeras
    Christian S Kuhr
    Department of Surgery, Urology and Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA
    Transplantation 73:1487-92. 2002
    ..These studies were undertaken to test whether the tolerance of host immune cells toward donor hematopoietic cells in mixed hematopoietic chimeras extends to include a vascularized organ, the kidney...