H Jonuleit

Summary

Affiliation: University of Mainz
Country: Germany

Publications

  1. pmc Infectious tolerance: human CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+) T helper cells
    Helmut Jonuleit
    Department of Dermatology, University of Mainz, 55101 Mainz, Germany
    J Exp Med 196:255-60. 2002
  2. ncbi request reprint CD4-mediated functional activation of human CD4+CD25+ regulatory T cells
    Christian Becker
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    Eur J Immunol 37:1217-23. 2007
  3. ncbi request reprint A comparison of two types of dendritic cell as adjuvants for the induction of melanoma-specific T-cell responses in humans following intranodal injection
    H Jonuleit
    Department of Dermatology, University of Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
    Int J Cancer 93:243-51. 2001
  4. ncbi request reprint The regulatory T cell family: distinct subsets and their interrelations
    Helmut Jonuleit
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    J Immunol 171:6323-7. 2003
  5. ncbi request reprint Induction of tumor peptide-specific cytotoxic T cells under serum-free conditions by mature human dendritic cells
    H Jonuleit
    Department of Dermatology, University of Mainz, Germany
    Arch Dermatol Res 292:325-32. 2000
  6. pmc Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells
    H Jonuleit
    Department of Dermatology, University of Mainz, D 55101 Mainz, Germany
    J Exp Med 192:1213-22. 2000
  7. pmc Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood
    H Jonuleit
    Department of Dermatology, University of Mainz, D 55101 Mainz, Germany
    J Exp Med 193:1285-94. 2001
  8. ncbi request reprint Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions
    H Jonuleit
    Department of Dermatology, University of Mainz, Germany
    Eur J Immunol 27:3135-42. 1997
  9. ncbi request reprint Interleukin-10-treated human dendritic cells induce a melanoma-antigen-specific anergy in CD8(+) T cells resulting in a failure to lyse tumor cells
    K Steinbrink
    Department of Dermatology, University of Mainz, Mainz, Germany and the Department of Dermatology, University of Erlangen, Erlangen, Germany
    Blood 93:1634-42. 1999
  10. ncbi request reprint Induction of dendritic cell maturation and modulation of dendritic cell-induced immune responses by prostaglandins
    K Steinbrink
    Department of Dermatology, University of Mainz, Langenbeckstr 1, 55131 Mainz, Germany
    Arch Dermatol Res 292:437-45. 2000

Collaborators

Detail Information

Publications35

  1. pmc Infectious tolerance: human CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+) T helper cells
    Helmut Jonuleit
    Department of Dermatology, University of Mainz, 55101 Mainz, Germany
    J Exp Med 196:255-60. 2002
    ..This explains previously published conflicting data on the role of TGF-beta in CD25(+) Treg cell-induced immunosuppression...
  2. ncbi request reprint CD4-mediated functional activation of human CD4+CD25+ regulatory T cells
    Christian Becker
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    Eur J Immunol 37:1217-23. 2007
    ..These results identify CD4 as a trigger for the suppressive function of CD25(+) Tregs and suggest a possible CD4-mediated exploitation of these cells...
  3. ncbi request reprint A comparison of two types of dendritic cell as adjuvants for the induction of melanoma-specific T-cell responses in humans following intranodal injection
    H Jonuleit
    Department of Dermatology, University of Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
    Int J Cancer 93:243-51. 2001
    ..Thus, our data define FCS-free cultured mature DCs as superior inducers of T-cell responses in melanoma patients...
  4. ncbi request reprint The regulatory T cell family: distinct subsets and their interrelations
    Helmut Jonuleit
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    J Immunol 171:6323-7. 2003
  5. ncbi request reprint Induction of tumor peptide-specific cytotoxic T cells under serum-free conditions by mature human dendritic cells
    H Jonuleit
    Department of Dermatology, University of Mainz, Germany
    Arch Dermatol Res 292:325-32. 2000
    ..These data show that terminally differentiated mature DC are necessary for the induction of tumor antigen-specific CTL responses...
  6. pmc Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells
    H Jonuleit
    Department of Dermatology, University of Mainz, D 55101 Mainz, Germany
    J Exp Med 192:1213-22. 2000
    ..These data show that immature and mature DCs induce different types of T cell responses: inflammatory Th1 cells are induced by mature DCs, and IL-10-producing T cell regulatory 1-like cells by immature DCs...
  7. pmc Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood
    H Jonuleit
    Department of Dermatology, University of Mainz, D 55101 Mainz, Germany
    J Exp Med 193:1285-94. 2001
    ..However, the refractory state of CD4(+)CD25(+) T cells was partially reversible by the addition of IL-2 or IL-4. These data demonstrate that human blood contains a resident T cell population with potent regulatory properties...
  8. ncbi request reprint Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions
    H Jonuleit
    Department of Dermatology, University of Mainz, Germany
    Eur J Immunol 27:3135-42. 1997
    ..TNF-alpha/IL-1, IL-6 + PGE2-cultured DC seem to be optimal for generation of IFN-gamma-producing CD4/CD8+ T cells...
  9. ncbi request reprint Interleukin-10-treated human dendritic cells induce a melanoma-antigen-specific anergy in CD8(+) T cells resulting in a failure to lyse tumor cells
    K Steinbrink
    Department of Dermatology, University of Mainz, Mainz, Germany and the Department of Dermatology, University of Erlangen, Erlangen, Germany
    Blood 93:1634-42. 1999
    ....
  10. ncbi request reprint Induction of dendritic cell maturation and modulation of dendritic cell-induced immune responses by prostaglandins
    K Steinbrink
    Department of Dermatology, University of Mainz, Langenbeckstr 1, 55131 Mainz, Germany
    Arch Dermatol Res 292:437-45. 2000
    ..Collectively, our data show that members of the PG family promote the differentiation of DC and enhance their capacity to induce a Th1 immune response...
  11. ncbi request reprint Mage-3 and influenza-matrix peptide-specific cytotoxic T cells are inducible in terminal stage HLA-A2.1+ melanoma patients by mature monocyte-derived dendritic cells
    B Schuler-Thurner
    Department of Dermatology, University of Erlangen Nuremberg, Erlangen, Germany
    J Immunol 165:3492-6. 2000
    ..Therefore, our DC vaccination strategy performs an adjuvant role and encourages further optimization of this new immunization approach...
  12. ncbi request reprint Priming of T cells with Ad-transduced DC followed by expansion with peptide-pulsed DC significantly enhances the induction of tumor-specific CD8+ T cells: implications for an efficient vaccination strategy
    A Tuettenberg
    Department of Dermatology, J Gutenberg University, Langenbeckstrasse 1, D 55101 Mainz, Germany
    Gene Ther 10:243-50. 2003
    ..Based on these data, we suggest a prime/boost vaccination strategy in melanoma patients--combining the use of Ad-DC and peptide-pulsed DC--to obtain efficient and long-term antitumor T-cell responses...
  13. ncbi request reprint Dendritic cells as a tool to induce anergic and regulatory T cells
    H Jonuleit
    Dept of Dermatology, University of Mainz, Langenbeckstr 1, D 55131 Mainz, Germany
    Trends Immunol 22:394-400. 2001
    ..What is the current state of knowledge of the "immunoregulatory" properties of dendritic cells and how might tolerance-inducing dendritic cells be relevant to therapeutic applications in humans?..
  14. ncbi request reprint Induction of strong and persistent MelanA/MART-1-specific immune responses by adjuvant dendritic cell-based vaccination of stage II melanoma patients
    Andrea Tuettenberg
    Department of Dermatology, Johannes Gutenberg University, Langenbeckstrasse 1, D 55101 Mainz, Germany
    Int J Cancer 118:2617-27. 2006
    ....
  15. ncbi request reprint Early adenoviral gene expression mediates immunosuppression by transduced dendritic cell (DC): implications for immunotherapy using genetically modified DC
    Andrea Tuettenberg
    Department of Dermatology, J Gutenberg University, Mainz, Germany
    J Immunol 172:1524-30. 2004
    ..These results have important implications for the use of genetically modified DC for therapeutic application...
  16. doi request reprint Generation of monoclonal antibodies against human regulatory T cells
    Christian Becker
    Department of Dermatology of University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstrasse1, 55101 Mainz, Germany
    J Immunol Methods 353:62-70. 2010
    ....
  17. doi request reprint CD40 signalling induces IL-10-producing, tolerogenic dendritic cells
    Andrea Tuettenberg
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    Exp Dermatol 19:44-53. 2010
    ..These data demonstrate that DC stimulated through CD40-CD40L interaction differentiate into tolerogenic DC with immunomodulatory function...
  18. doi request reprint Protection from graft-versus-host disease by HIV-1 envelope protein gp120-mediated activation of human CD4+CD25+ regulatory T cells
    Christian Becker
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    Blood 114:1263-9. 2009
    ..Our findings demonstrate that stimulation via the CD4 receptor represents a T-cell receptor-independent Treg activating pathway with potential to induce immunologic tolerance in vivo...
  19. doi request reprint The role of ICOS in directing T cell responses: ICOS-dependent induction of T cell anergy by tolerogenic dendritic cells
    Andrea Tuettenberg
    Department of Dermatology, University of Mainz, Mainz, Germany
    J Immunol 182:3349-56. 2009
    ..Taken together, these results indicate a crucial role for ICOS in the induction of peripheral tolerance maintained by tolerogenic DC mediated mostly via an IL-10-independent mechanism...
  20. doi request reprint Myeloid dendritic cell: From sentinel of immunity to key player of peripheral tolerance?
    Kerstin Steinbrink
    Department of Dermatology, Johannes Gutenberg University Mainz, Mainz, Germany
    Hum Immunol 70:289-93. 2009
    ....
  21. ncbi request reprint Dendritic cell-based immunotherapy of malignant melanoma: success and limitations
    Andrea Tuettenberg
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    J Dtsch Dermatol Ges 5:190-6. 2007
    ..These studies open a new way for "conditioning" of DC by TLRL and might significantly enhance the efficiency of DC-based melanoma vaccines in the future...
  22. ncbi request reprint Oxymetazoline modulates proinflammatory cytokines and the T-cell stimulatory capacity of dendritic cells
    Andrea Tuettenberg
    Department of Dermatology, University of Mainz, Mainz, Germany
    Exp Dermatol 16:171-8. 2007
    ..Therefore, the therapeutic benefit of OMZ can be explained in part by its immunomodulating effects in the topical treatment of nasal inflammation...
  23. ncbi request reprint Immature, but not inactive: the tolerogenic function of immature dendritic cells
    Karsten Mahnke
    Department of Dermatology and Institute of Immunology, University of Mainz, Germany
    Immunol Cell Biol 80:477-83. 2002
    ..This review summarizes the current knowledge about the immunoregulatory role of immature DC that might act as guardians for the induction and maintenance of T cell tolerance in the periphery...
  24. ncbi request reprint Human CD25+ regulatory T cells: two subsets defined by the integrins alpha 4 beta 7 or alpha 4 beta 1 confer distinct suppressive properties upon CD4+ T helper cells
    Michael Stassen
    Institute of Immunology, Johannes Gutenberg University, Mainz, Germany
    Eur J Immunol 34:1303-11. 2004
    ....
  25. ncbi request reprint Dendritic cells: sentinels of immunity and tolerance
    Jan Kubach
    Department of Dermatology, University of Mainz, Germany
    Int J Hematol 81:197-203. 2005
    ..This brief review summarizes the current knowledge about the immunoregulatory role of DC as guardians for the induction of T-cell immunity and tolerance...
  26. ncbi request reprint Different efficiency of heat shock proteins (HSP) to activate human monocytes and dendritic cells: superiority of HSP60
    Karen Bethke
    First Department of Internal Medicine and Department of Dermatology, Johannes Gutenberg Universitat, Mainz, Germany
    J Immunol 169:6141-8. 2002
    ..These findings show that HSP can differ considerably in the capacity to activate monocyte-derived APC under certain conditions and underline the potential of HSP60 and HSP72 as activation signals for the innate immune system...
  27. ncbi request reprint Regulatory T-cells in antitumor therapy: isolation and functional testing of CD4+CD25+ regulatory T-cells
    Helmut Jonuleit
    Department of Dermatology, Universitatsklinik Mainz, Mainz, Germany
    Methods Mol Med 109:285-96. 2005
    ..Additionally, co-culture assays for functional characterization of isolated CD4+CD25+ regulatory T-cells are described that are able to detect their suppressive properties for conventional CD4+ T-cells with high sensitivity...
  28. ncbi request reprint Regulatory T cells--the renaissance of the suppressor T cells
    Tobias Bopp
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    Ann Med 39:322-34. 2007
    ..Herein, we give a comprehensive review about this research on T regulatory cells and the relevance of this suppressive T cell population for the development of innovative immune therapeutic strategies...
  29. ncbi request reprint Human CD(4+)CD(25+) regulatory T cells and infectious tolerance
    Michael Stassen
    Institute of Immunology, Johannes Gutenberg University, Mainz, Germany
    Transplantation 77:S23-5. 2004
    ..Thus, our findings reconcile contradictory results clearly demonstrating that suppression is contact dependent in vitro but mediated by soluble factors (IL-10 and TGF-beta) in vivo...
  30. ncbi request reprint Immune regulation by regulatory T cells: implications for transplantation
    Helmut Jonuleit
    Department of Dermatology, University of Mainz, Hochhaus am Augustusplatz, Langenbeckstr 1, 55101 Mainz, Germany
    Transpl Immunol 11:267-76. 2003
    ..This review summarises the current knowledge regarding the immunoregulatory role of dendritic cells and the functional activities of resident regulatory T cells as guardians for peripheral T cell tolerance...
  31. ncbi request reprint Human CD4+CD25+ regulatory T cells: proteome analysis identifies galectin-10 as a novel marker essential for their anergy and suppressive function
    Jan Kubach
    Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
    Blood 110:1550-8. 2007
    ..Notably, first identified here as expressed in human T lymphocytes, galectin-10 is essential for the functional properties of CD25(+) Treg cells...
  32. ncbi request reprint Interaction of TLR2 and TLR4 ligands with the N-terminal domain of Gp96 amplifies innate and adaptive immune responses
    Tobias Warger
    Institute of Immunology, University of Mainz, Obere Zahlbacherstrasse 67, 55131 Mainz, Germany
    J Biol Chem 281:22545-53. 2006
    ....
  33. ncbi request reprint ICOS and CD28 reversely regulate IL-10 on re-activation of human effector T cells with mature dendritic cells
    Esther J Witsch
    Molecular Immunology, Robert Koch Institute, Berlin, Germany
    Eur J Immunol 32:2680-6. 2002
    ..Our data thus indicate a selective regulation of IL-10 secretion by ICOS on re-activation of effector T cells with professional antigen-presenting cells (bearing CD80 and CD86) in lymphoid tissue...
  34. ncbi request reprint Differential regulatory capacity of CD25+ T regulatory cells and preactivated CD25+ T regulatory cells on development, functional activation, and proliferation of Th2 cells
    Michael Stassen
    Institute of Immunology, Johannes Gutenberg University, Hochhaus am Augustusplatz, D 55101 Mainz, Germany
    J Immunol 173:267-74. 2004
    ..Hence, our study indicates that CD25+ Treg cells have a therapeutic potential for Th2-mediated diseases and suggests a novel mechanism of suppression mediated by the transcriptional repressor FoxP3...
  35. pmc Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression
    Tobias Bopp
    Institute for Immunology, Johannes Gutenberg University, 55131 Mainz, Germany
    J Exp Med 204:1303-10. 2007
    ..Hence, naturally occurring T reg cells unexpectedly may control the immune regulatory network by a well-known mechanism based on the intercellular transport of cAMP via gap junctions...