Research Topics
Species | H JonuleitSummaryAffiliation: University of Mainz Country: Germany Publications
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Detail Information
Publications
Infectious tolerance: human CD25(+) regulatory T cells convey suppressor activity to conventional CD4(+) T helper cellsHelmut Jonuleit
Department of Dermatology, University of Mainz, 55101 Mainz, Germany
J Exp Med 196:255-60. 2002..This explains previously published conflicting data on the role of TGF-beta in CD25(+) Treg cell-induced immunosuppression...
CD4-mediated functional activation of human CD4+CD25+ regulatory T cellsChristian Becker
Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
Eur J Immunol 37:1217-23. 2007..These results identify CD4 as a trigger for the suppressive function of CD25(+) Tregs and suggest a possible CD4-mediated exploitation of these cells...- A comparison of two types of dendritic cell as adjuvants for the induction of melanoma-specific T-cell responses in humans following intranodal injectionH Jonuleit
Department of Dermatology, University of Mainz, Langenbeckstrasse 1, 55101 Mainz, Germany
Int J Cancer 93:243-51. 2001..Thus, our data define FCS-free cultured mature DCs as superior inducers of T-cell responses in melanoma patients... - The regulatory T cell family: distinct subsets and their interrelationsHelmut Jonuleit
Department of Dermatology, Johannes Gutenberg-University, Mainz, Germany
J Immunol 171:6323-7. 2003 - Induction of tumor peptide-specific cytotoxic T cells under serum-free conditions by mature human dendritic cellsH Jonuleit
Department of Dermatology, University of Mainz, Germany
Arch Dermatol Res 292:325-32. 2000..These data show that terminally differentiated mature DC are necessary for the induction of tumor antigen-specific CTL responses... - Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cellsH Jonuleit
Department of Dermatology, University of Mainz, D 55101 Mainz, Germany
J Exp Med 192:1213-22. 2000..These data show that immature and mature DCs induce different types of T cell responses: inflammatory Th1 cells are induced by mature DCs, and IL-10-producing T cell regulatory 1-like cells by immature DCs... - Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral bloodH Jonuleit
Department of Dermatology, University of Mainz, D 55101 Mainz, Germany
J Exp Med 193:1285-94. 2001..However, the refractory state of CD4(+)CD25(+) T cells was partially reversible by the addition of IL-2 or IL-4. These data demonstrate that human blood contains a resident T cell population with potent regulatory properties... - Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditionsH Jonuleit
Department of Dermatology, University of Mainz, Germany
Eur J Immunol 27:3135-42. 1997..TNF-alpha/IL-1, IL-6 + PGE2-cultured DC seem to be optimal for generation of IFN-gamma-producing CD4/CD8+ T cells... - Interleukin-10-treated human dendritic cells induce a melanoma-antigen-specific anergy in CD8(+) T cells resulting in a failure to lyse tumor cellsK Steinbrink
Department of Dermatology, University of Mainz, Mainz, Germany and the Department of Dermatology, University of Erlangen, Erlangen, Germany
Blood 93:1634-42. 1999.... - Induction of dendritic cell maturation and modulation of dendritic cell-induced immune responses by prostaglandinsK Steinbrink
Department of Dermatology, University of Mainz, Langenbeckstr 1, 55131 Mainz, Germany
Arch Dermatol Res 292:437-45. 2000..Collectively, our data show that members of the PG family promote the differentiation of DC and enhance their capacity to induce a Th1 immune response... - Mage-3 and influenza-matrix peptide-specific cytotoxic T cells are inducible in terminal stage HLA-A2.1+ melanoma patients by mature monocyte-derived dendritic cellsB Schuler-Thurner
Department of Dermatology, University of Erlangen Nuremberg, Erlangen, Germany
J Immunol 165:3492-6. 2000..Therefore, our DC vaccination strategy performs an adjuvant role and encourages further optimization of this new immunization approach... - Priming of T cells with Ad-transduced DC followed by expansion with peptide-pulsed DC significantly enhances the induction of tumor-specific CD8+ T cells: implications for an efficient vaccination strategyA Tuettenberg
Department of Dermatology, J. Gutenberg-University, Langenbeckstrasse 1, D-55101 Mainz, Germany
Gene Ther 10:243-50. 2003..Based on these data, we suggest a prime/boost vaccination strategy in melanoma patients--combining the use of Ad-DC and peptide-pulsed DC--to obtain efficient and long-term antitumor T-cell responses... - Dendritic cells as a tool to induce anergic and regulatory T cellsH Jonuleit
Dept of Dermatology, University of Mainz, Langenbeckstr 1, D 55131 Mainz, Germany
Trends Immunol 22:394-400. 2001..What is the current state of knowledge of the "immunoregulatory" properties of dendritic cells and how might tolerance-inducing dendritic cells be relevant to therapeutic applications in humans?.. - Induction of strong and persistent MelanA/MART-1-specific immune responses by adjuvant dendritic cell-based vaccination of stage II melanoma patientsAndrea Tuettenberg
Department of Dermatology, Johannes Gutenberg-University, Langenbeckstrasse 1, D-55101 Mainz, Germany
Int J Cancer 118:2617-27. 2006.... - Early adenoviral gene expression mediates immunosuppression by transduced dendritic cell (DC): implications for immunotherapy using genetically modified DCAndrea Tuettenberg
Department of Dermatology, J. Gutenberg-University, Mainz, Germany
J Immunol 172:1524-30. 2004..These results have important implications for the use of genetically modified DC for therapeutic application... 
Generation of monoclonal antibodies against human regulatory T cellsChristian Becker
Department of Dermatology of University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstrasse1, 55101 Mainz, Germany
J Immunol Methods 353:62-70. 2010....- CD40 signalling induces IL-10-producing, tolerogenic dendritic cellsAndrea Tuettenberg
Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
Exp Dermatol 19:44-53. 2010..These data demonstrate that DC stimulated through CD40-CD40L interaction differentiate into tolerogenic DC with immunomodulatory function... - Protection from graft-versus-host disease by HIV-1 envelope protein gp120-mediated activation of human CD4+CD25+ regulatory T cellsChristian Becker
Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
Blood 114:1263-9. 2009..Our findings demonstrate that stimulation via the CD4 receptor represents a T-cell receptor-independent Treg activating pathway with potential to induce immunologic tolerance in vivo... - The role of ICOS in directing T cell responses: ICOS-dependent induction of T cell anergy by tolerogenic dendritic cellsAndrea Tuettenberg
Department of Dermatology, University of Mainz, Mainz, Germany
J Immunol 182:3349-56. 2009..Taken together, these results indicate a crucial role for ICOS in the induction of peripheral tolerance maintained by tolerogenic DC mediated mostly via an IL-10-independent mechanism... - Myeloid dendritic cell: From sentinel of immunity to key player of peripheral tolerance?Kerstin Steinbrink
Department of Dermatology, Johannes Gutenberg University Mainz, Mainz, Germany
Hum Immunol 70:289-93. 2009.... - Dendritic cell-based immunotherapy of malignant melanoma: success and limitationsAndrea Tuettenberg
Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
J Dtsch Dermatol Ges 5:190-6. 2007..These studies open a new way for "conditioning" of DC by TLRL and might significantly enhance the efficiency of DC-based melanoma vaccines in the future... - Oxymetazoline modulates proinflammatory cytokines and the T-cell stimulatory capacity of dendritic cellsAndrea Tuettenberg
Department of Dermatology, University of Mainz, Mainz, Germany
Exp Dermatol 16:171-8. 2007..Therefore, the therapeutic benefit of OMZ can be explained in part by its immunomodulating effects in the topical treatment of nasal inflammation... - Immature, but not inactive: the tolerogenic function of immature dendritic cellsKarsten Mahnke
Department of Dermatology and Institute of Immunology, University of Mainz, Germany
Immunol Cell Biol 80:477-83. 2002..This review summarizes the current knowledge about the immunoregulatory role of immature DC that might act as guardians for the induction and maintenance of T cell tolerance in the periphery... - Human CD25+ regulatory T cells: two subsets defined by the integrins alpha 4 beta 7 or alpha 4 beta 1 confer distinct suppressive properties upon CD4+ T helper cellsMichael Stassen
Institute of Immunology, Johannes Gutenberg-University, Mainz, Germany
Eur J Immunol 34:1303-11. 2004.... - Dendritic cells: sentinels of immunity and toleranceJan Kubach
Department of Dermatology, University of Mainz, Germany
Int J Hematol 81:197-203. 2005..This brief review summarizes the current knowledge about the immunoregulatory role of DC as guardians for the induction of T-cell immunity and tolerance... - Different efficiency of heat shock proteins (HSP) to activate human monocytes and dendritic cells: superiority of HSP60Karen Bethke
First Department of Internal Medicine and Department of Dermatology, , Mainz, Germany
J Immunol 169:6141-8. 2002..These findings show that HSP can differ considerably in the capacity to activate monocyte-derived APC under certain conditions and underline the potential of HSP60 and HSP72 as activation signals for the innate immune system... - Regulatory T-cells in antitumor therapy: isolation and functional testing of CD4+CD25+ regulatory T-cellsHelmut Jonuleit
Department of Dermatology, , Mainz, Germany
Methods Mol Med 109:285-96. 2005..Additionally, co-culture assays for functional characterization of isolated CD4+CD25+ regulatory T-cells are described that are able to detect their suppressive properties for conventional CD4+ T-cells with high sensitivity... - Regulatory T cells--the renaissance of the suppressor T cellsTobias Bopp
Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
Ann Med 39:322-34. 2007..Herein, we give a comprehensive review about this research on T regulatory cells and the relevance of this suppressive T cell population for the development of innovative immune therapeutic strategies... - Human CD(4+)CD(25+) regulatory T cells and infectious toleranceMichael Stassen
Institute of Immunology, Johannes Gutenberg University, Mainz, Germany
Transplantation 77:S23-5. 2004..Thus, our findings reconcile contradictory results clearly demonstrating that suppression is contact dependent in vitro but mediated by soluble factors (IL-10 and TGF-beta) in vivo... - Immune regulation by regulatory T cells: implications for transplantationHelmut Jonuleit
Department of Dermatology, University of Mainz, Hochhaus am Augustusplatz, Langenbeckstr. 1, 55101 Mainz, Germany
Transpl Immunol 11:267-76. 2003..This review summarises the current knowledge regarding the immunoregulatory role of dendritic cells and the functional activities of resident regulatory T cells as guardians for peripheral T cell tolerance... - Human CD4+CD25+ regulatory T cells: proteome analysis identifies galectin-10 as a novel marker essential for their anergy and suppressive functionJan Kubach
Department of Dermatology, Johannes Gutenberg University, Mainz, Germany
Blood 110:1550-8. 2007..Notably, first identified here as expressed in human T lymphocytes, galectin-10 is essential for the functional properties of CD25(+) Treg cells... - Interaction of TLR2 and TLR4 ligands with the N-terminal domain of Gp96 amplifies innate and adaptive immune responsesTobias Warger
Institute of Immunology, University of Mainz, Obere Zahlbacherstrasse 67, 55131 Mainz, Germany
J Biol Chem 281:22545-53. 2006.... - ICOS and CD28 reversely regulate IL-10 on re-activation of human effector T cells with mature dendritic cellsEsther J Witsch
Molecular Immunology, Robert Koch Institute, Berlin, Germany
Eur J Immunol 32:2680-6. 2002..Our data thus indicate a selective regulation of IL-10 secretion by ICOS on re-activation of effector T cells with professional antigen-presenting cells (bearing CD80 and CD86) in lymphoid tissue... - Differential regulatory capacity of CD25+ T regulatory cells and preactivated CD25+ T regulatory cells on development, functional activation, and proliferation of Th2 cellsMichael Stassen
Institute of Immunology, Johannes Gutenberg University, Hochhaus am Augustusplatz, D-55101 Mainz, Germany
J Immunol 173:267-74. 2004..Hence, our study indicates that CD25+ Treg cells have a therapeutic potential for Th2-mediated diseases and suggests a novel mechanism of suppression mediated by the transcriptional repressor FoxP3... - Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppressionTobias Bopp
Institute for Immunology, Johannes Gutenberg University, 55131 Mainz, Germany
J Exp Med 204:1303-10. 2007..Hence, naturally occurring T reg cells unexpectedly may control the immune regulatory network by a well-known mechanism based on the intercellular transport of cAMP via gap junctions...