Sven Jonas

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. ncbi request reprint Prognostic significance of the DNA-index in liver transplantation for hepatocellular carcinoma in cirrhosis
    Sven Jonas
    Department of General, Visceral, and Transplantation Surgery, Charite Campus Virchow Klinikum, University Medicine Berlin, Berlin, Germany
    Ann Surg 250:1008-13. 2009
  2. doi request reprint Extended liver resection for intrahepatic cholangiocarcinoma: A comparison of the prognostic accuracy of the fifth and sixth editions of the TNM classification
    Sven Jonas
    Department of General, Visceral, and Transplantation Surgery, Charité Universitaetsmedzin Berlin, Germany
    Ann Surg 249:303-9. 2009
  3. doi request reprint Influence of donor- and recipient-specific factors on the postoperative course after combined pancreas-kidney transplantation
    Peter Thomas Fellmer
    Department of General, Visceral and Transplant Surgery, Charite Campus Virchow, Berlin, Germany
    Langenbecks Arch Surg 395:19-25. 2010
  4. doi request reprint Salvage therapy for relapsed posttransplant lymphoproliferative disorders (PTLD) with a second progression of PTLD after Upfront chemotherapy: the role of single-agent rituximab
    Ralf U Trappe
    Department of Hematology and Oncology, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    Transplantation 84:1708-12. 2007
  5. doi request reprint Oncological superiority of hilar en bloc resection for the treatment of hilar cholangiocarcinoma
    Peter Neuhaus
    Department of General, Visceral, and Transplantation Surgery, Charite Campus Virchow, Berlin, Germany
    Ann Surg Oncol 19:1602-8. 2012
  6. doi request reprint Microvessel density correlates with lymph node metastases and prognosis in hilar cholangiocarcinoma
    Armin Thelen
    Department of General, Visceral and Transplantation Surgery, Charite Universitaetsmedizin Berlin, Berlin, Germany
    J Gastroenterol 43:959-66. 2008
  7. doi request reprint Eighteen years of liver transplantation experience in patients with advanced Budd-Chiari syndrome
    Frank Ulrich
    Department of General, Visceral, and Transplantation Surgery, Charite, Campus Virchow Clinical Centre, Berlin, Germany
    Liver Transpl 14:144-50. 2008
  8. ncbi request reprint Nonresponse to pre-operative chemotherapy does not preclude long-term survival after liver resection in patients with colorectal liver metastases
    Ulf P Neumann
    Department of General, Visceral, and Transplantation Surgery, Universitatsklinikum Charite, Campus Virchow Klinikum, Humboldt Universitat, Berlin, Germany
    Surgery 146:52-9. 2009
  9. ncbi request reprint Living donor liver transplantation of the right lobe for hepatocellular carcinoma in cirrhosis in a European center
    Sven Jonas
    Department of General, Visceral and Transplantation Surgery, Charite Campus Virchow Klinikum, University Medicine Berlin, Germany
    Liver Transpl 13:896-903. 2007
  10. ncbi request reprint Salvage chemotherapy for refractory and relapsed posttransplant lymphoproliferative disorders (PTLD) after treatment with single-agent rituximab
    Ralf Trappe
    1Department of Hematology and Oncology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Transplantation 83:912-8. 2007

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Prognostic significance of the DNA-index in liver transplantation for hepatocellular carcinoma in cirrhosis
    Sven Jonas
    Department of General, Visceral, and Transplantation Surgery, Charite Campus Virchow Klinikum, University Medicine Berlin, Berlin, Germany
    Ann Surg 250:1008-13. 2009
    ..This study was conducted to evaluate the prognostic significance of the tumor DNA index in patients receiving liver transplantation for hepatocellular carcinoma (HCC) in cirrhosis...
  2. doi request reprint Extended liver resection for intrahepatic cholangiocarcinoma: A comparison of the prognostic accuracy of the fifth and sixth editions of the TNM classification
    Sven Jonas
    Department of General, Visceral, and Transplantation Surgery, Charité Universitaetsmedzin Berlin, Germany
    Ann Surg 249:303-9. 2009
    ..The present study was conducted to analyze the outcome after liver resection for intrahepatic cholangiocarcinoma (IHC) and to compare the prognostic accuracy of the fifth and sixth editions of the TNM classification of malignant tumors...
  3. doi request reprint Influence of donor- and recipient-specific factors on the postoperative course after combined pancreas-kidney transplantation
    Peter Thomas Fellmer
    Department of General, Visceral and Transplant Surgery, Charite Campus Virchow, Berlin, Germany
    Langenbecks Arch Surg 395:19-25. 2010
    ..Pancreas transplantation is associated with postoperative complications. We defined and identified donor- and recipient-specific factors related to postoperative complications...
  4. doi request reprint Salvage therapy for relapsed posttransplant lymphoproliferative disorders (PTLD) with a second progression of PTLD after Upfront chemotherapy: the role of single-agent rituximab
    Ralf U Trappe
    Department of Hematology and Oncology, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
    Transplantation 84:1708-12. 2007
    ..Single-agent rituximab salvage therapy is an effective treatment option in this setting of intensively pretreated patients, with virtually no therapy-associated toxicity...
  5. doi request reprint Oncological superiority of hilar en bloc resection for the treatment of hilar cholangiocarcinoma
    Peter Neuhaus
    Department of General, Visceral, and Transplantation Surgery, Charite Campus Virchow, Berlin, Germany
    Ann Surg Oncol 19:1602-8. 2012
    ..The present study was conducted to analyze its oncological effectiveness compared to conventional hepatectomy...
  6. doi request reprint Microvessel density correlates with lymph node metastases and prognosis in hilar cholangiocarcinoma
    Armin Thelen
    Department of General, Visceral and Transplantation Surgery, Charite Universitaetsmedizin Berlin, Berlin, Germany
    J Gastroenterol 43:959-66. 2008
    ..The present study was conducted to analyze tumor-associated neovascularization in hilar cholangiocarcinoma and to determine its influence on tumor growth, metastasis, recurrence, and prognosis...
  7. doi request reprint Eighteen years of liver transplantation experience in patients with advanced Budd-Chiari syndrome
    Frank Ulrich
    Department of General, Visceral, and Transplantation Surgery, Charite, Campus Virchow Clinical Centre, Berlin, Germany
    Liver Transpl 14:144-50. 2008
    ..In conclusion, patients with reversible hepatic damage should be treated by combined strategies, including medical therapy and surgical or interventional shunting...
  8. ncbi request reprint Nonresponse to pre-operative chemotherapy does not preclude long-term survival after liver resection in patients with colorectal liver metastases
    Ulf P Neumann
    Department of General, Visceral, and Transplantation Surgery, Universitatsklinikum Charite, Campus Virchow Klinikum, Humboldt Universitat, Berlin, Germany
    Surgery 146:52-9. 2009
    ..The aim of the study was to identify risk factors for poor outcome in patients with pre-operative chemotherapy of CRM...
  9. ncbi request reprint Living donor liver transplantation of the right lobe for hepatocellular carcinoma in cirrhosis in a European center
    Sven Jonas
    Department of General, Visceral and Transplantation Surgery, Charite Campus Virchow Klinikum, University Medicine Berlin, Germany
    Liver Transpl 13:896-903. 2007
    ..So far, the outcome of the patients is in favor of a careful extension of the selection criteria for HCC in cirrhosis...
  10. ncbi request reprint Salvage chemotherapy for refractory and relapsed posttransplant lymphoproliferative disorders (PTLD) after treatment with single-agent rituximab
    Ralf Trappe
    1Department of Hematology and Oncology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Transplantation 83:912-8. 2007
    ..This retrospective analysis was undertaken to determine the efficacy and safety of salvage therapy in recipients of solid organ transplants with progression of PTLD after rituximab first-line therapy...
  11. doi request reprint Radiofrequency ablation prior to liver transplantation: focus on complications and on a rare but severe case
    Robert M Eisele
    Department of General, Visceral and Transplantation Surgery, Charite Virchow Clinic, Berlin, Germany
    Clin Transplant 22:20-8. 2008
    ..Complications are thought to be rare and mostly self-limiting. By contrast, we report on a life-threatening complication and discuss it in the context of other complications...
  12. ncbi request reprint Extended indications in living-donor liver transplantation: bile duct cancer
    Sven Jonas
    Department of General, Visceral and Transplantation Surgery, Charite Campus Virchow Klinikum, Universitatsmedizin Berlin, Berlin, Germany
    Transplantation 80:S101-4. 2005
    ..Living donor liver transplantation may be beneficial in selected patients suffering from Klatskin tumors, whereas caution should prevail when considering intrahepatic cholangiocarcinoma...
  13. ncbi request reprint Hepatic resection in liver transplant recipients: single center experience and review of the literature
    Olaf Guckelberger
    Department of General, Visceral and Transplantation Surgery, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany olaf
    Am J Transplant 5:2403-9. 2005
    ..In conclusion, partial graft hepatectomy can be considered a safe and beneficial procedure in selected liver transplant recipients with anatomical limited biliary injury, thereby, preserving scarce donor organs...
  14. doi request reprint Long-term outcome of liver resection and transplantation for Caroli disease and syndrome
    Frank Ulrich
    Department of General, Visceral and Transplantation Surgery, Charite, Campus Virchow Clinical Centre, Berlin, Germany
    Ann Surg 247:357-64. 2008
    ....
  15. ncbi request reprint Increased mortality after liver transplantation for hepatocellular carcinoma in hepatitis B-associated cirrhosis
    Sven Jonas
    Department of General, Visceral, and Transplantation Surgery, Charite Campus Virchow Klinikum, Humboldt University Berlin, Augustenburger Platz 1, 13353, Berlin, Germany
    Transpl Int 16:33-6. 2003
    ..22%; P<0.05). This difference was due to unspecific causes, not to tumor recurrence or re-infection. These findings may be indicative of a more complicated course in patients suffering from hepatitis B in general...
  16. doi request reprint Extended bile duct resection and [corrected] liver and transplantation in patients with hilar cholangiocarcinoma: long-term results
    Daniel Seehofer
    Department of General, Visceral, and Transplant Surgery, Charite Campus Virchow, Berlin, Germany
    Liver Transpl 15:1499-507. 2009
    ..To further improve the results, other approaches such as (neo)adjuvant therapy have to be increasingly investigated...
  17. ncbi request reprint Validation of cardiovascular risk scores in a liver transplant population
    Olaf Guckelberger
    Department of General, Visceral and Transplantation Surgery, Charité Campus Vichow Klinikum, Berlin, Germany
    Liver Transpl 12:394-401. 2006
    ..Furthermore, calibrated PROCAM risk estimates are required to calculate the number of patients needed to treat in the setup of prospective intervention trials...
  18. ncbi request reprint Retrograde reperfusion via vena cava lowers the risk of initial nonfunction but increases the risk of ischemic-type biliary lesions in liver transplantation--a randomized clinical trial
    Christoph Heidenhain
    Department of General, Visceral and Transplantation Surgery, Charite, Campus Virchow, Universitatsmedizin Berlin, Berlin, Germany
    Transpl Int 19:738-48. 2006
    ..053). Retrograde reperfusion seemed to be beneficial for hepatocytes, but was detrimental for the biliary epithelium. The unexplained increased incidence of ITBL after retrograde reperfusion will be focus of further investigation...
  19. ncbi request reprint Simultaneous versus staged liver resection of synchronous liver metastases from colorectal cancer
    Armin Thelen
    Department of General, Visceral and Transplant Surgery, Campus Virchow Klinikum, Charite Universitatsmedizin Berlin, Berlin, Germany
    Int J Colorectal Dis 22:1269-76. 2007
    ..This retrospective analysis was conducted to compare the postoperative outcome and survival of patients receiving simultaneous resection of liver metastases and primary colorectal cancer to those receiving staged resection...
  20. ncbi request reprint Liver resection for metastases from breast cancer
    Armin Thelen
    Department of General, Visceral and Transplantation Surgery, Campus Virchow Klinikum, Charite Universitaetsmedizin Berlin, Berlin, Germany
    J Surg Oncol 97:25-9. 2008
    ..This study was conducted to clarify safety and effectiveness of hepatectomy in this conditions and to identify selection criteria for patients suitable for liver resection...
  21. doi request reprint Tumor-associated lymphangiogenesis correlates with lymph node metastases and prognosis in hilar cholangiocarcinoma
    Armin Thelen
    Department of General, Visceral and Transplantation Surgery, Campus Virchow Klinikum, Charite Universitaetsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany
    Ann Surg Oncol 15:791-9. 2008
    ..Currently, nothing is known about the impact of lymphangiogenesis on progression and prognosis in hilar cholangiocarcinoma...
  22. doi request reprint VEGF-D promotes tumor growth and lymphatic spread in a mouse model of hepatocellular carcinoma
    Armin Thelen
    Department of General, Visceral and Transplantation Surgery, Campus Virchow Klinikum, Charite Universitaetsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Int J Cancer 122:2471-81. 2008
    ..In conclusion, our study suggests that expression of VEGF-D is involved in growth and lymphatic spread of HCC. Therefore, VEGF-D might represent a therapeutic target in HCC...
  23. ncbi request reprint Human hepatocytes are protected from ethanol-induced cytotoxicity by DADS via CYP2E1 inhibition
    Masashi Shimada
    Department of General, Visceral, and Transplantation Surgery, Charite, Campus Virchow, Humboldt University of Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Toxicol Lett 163:242-9. 2006
    ..Our data show that DADS reduces ethanol-induced toxicity in human hepatocytes by reducing CYP2E1 activity and/or stabilizing the cellular GSH content, which might be of therapeutic interest...
  24. ncbi request reprint Epstein-Barr viral load in whole blood of adults with posttransplant lymphoproliferative disorder after solid organ transplantation does not correlate with clinical course
    Stephan Oertel
    Department of Hematology and Oncology, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353, Berlin, Germany
    Ann Hematol 85:478-84. 2006
    ..We conclude that in adult patients with PTLD, EBV load does not correlate with treatment response and is not suitable as a predictive marker for PTLD relapse...
  25. ncbi request reprint Changing impact of cytomegalovirus in liver transplantation -- a single centre experience of more than 1000 transplantations without ganciclovir prophylaxis
    Daniel Seehofer
    Department of General, Visceral and Transplant Surgery, Humboldt University of Berlin, Berlin, Germany
    Transpl Int 18:941-8. 2005
    ..As D+R- patients still more often develop symptomatic disease, pre-emptive therapy could be useful in this patient group...
  26. ncbi request reprint Supply of pre- and probiotics reduces bacterial infection rates after liver transplantation--a randomized, double-blind trial
    Nada Rayes
    Department of General, Visceral and Transplant Surgery, Charite Campus Virchow, Humboldt University, Berlin, Germany
    Am J Transplant 5:125-30. 2005
    ..Early enteral nutrition supplemented with a mixture of LAB and fibers reduces bacterial infection rates following liver transplantation. Treatment with only fibers led to a low incidence of severe infections...
  27. ncbi request reprint Harm from seat belt: transthoracic lung herniation and pericardial rupture
    Christoph Benckert
    Department of General, Visceral and Transplantation Surgery, Charite, Campus Virchow, Universitatsmedizin Berlin, Berlin, Germany
    J Thorac Cardiovasc Surg 133:588-9. 2007
  28. ncbi request reprint [Living donor liver transplantation from the perspective of the donor: results of a psychosomatic investigation]
    Marc Walter
    Medizinische Klinik mit Schwerpunkt Psychosomatik der Charité, Berlin, Germany
    Z Psychosom Med Psychother 51:331-45. 2005
    ..The aims were to describe the clinical problems before and after transplantation and to contribute to the discussion of ethical issues based on empirical findings...
  29. ncbi request reprint Surgical resection of colorectal metastases
    Sven Jonas
    Department of General, Visceral, and Transplantation Surgery, Charite Campus Virchow Klinikum, Humboldt University of Berlin, Berlin, Germany
    Front Radiat Ther Oncol 38:94-9. 2004
  30. ncbi request reprint DNA analysis of cholangiocarcinoma cells: prognostic and clinical importance
    Hassan Abou-Rebyeh
    Department of Internal Medicine, Hepatology and Gastroenterology, Humboldt University, Charite, Berlin, Germany
    Cancer Detect Prev 26:313-9. 2002
    ..DNA ploidy reflecting irregularities of chromosome number and content might be an alternative predictor. In this study, we evaluated the DNA ploidy as a prognostic factor for survival of patients after resection of cholangiocarcinoma...
  31. ncbi request reprint The impact of immune-activating processes following transplantation on chronic allograft nephropathy
    Christoph Heidenhain
    Department of General and Transplantation Surgery Charité Campus Virchow Clinic, Berlin, Germany
    Kidney Int 64:1125-33. 2003
    ..However, only very little information is presently available on the influence of systemic immune-activating processes following organ engraftment...
  32. ncbi request reprint A survival-based scoring-system for initial graft function following orthotopic liver transplantation
    Michael Heise
    Department of Surgery, Humboldt University of Berlin, Charite, Augustenburger Platz 1, 13353, Berlin, Germany
    Transpl Int 16:794-800. 2003
    ..We can conclude that the presented refined scoring-system for initial graft function provides a significant correlation to patient survival and initial non-function. We recommend the refined system for future studies...
  33. ncbi request reprint Sirolimus inhibits growth of human hepatoma cells alone or combined with tacrolimus, while tacrolimus promotes cell growth
    Guido Schumacher
    Department of General, Visceral, and Transplantation Surgery, Charite Campus Virchow Klinikum, Humboldt University, Augustenburger Platz 1, Berlin 13353, Germany
    World J Gastroenterol 11:1420-5. 2005
    ..The purpose is to assess the effect on tumor growth of the immuno-suppressive compounds sirolimus and tacrolimus alone and in combination on cells of human hepatocellular carcinoma...
  34. ncbi request reprint Salvage chemotherapy for refractory or relapsed post-transplant lymphoproliferative disorder in patients after solid organ transplantation with a combination of carboplatin and etoposide
    Stephan H Oertel
    Humboldt Universitat Berlin, Medizinische Klinik mit Schwerpunkt Hämatologie und Onkologie, Berlin, Germany
    Br J Haematol 123:830-5. 2003
    ....
  35. doi request reprint Tumor-associated lymphangiogenesis correlates with prognosis after resection of human hepatocellular carcinoma
    Armin Thelen
    Department of Visceral, Transplantation, Thoracic and Vascular Surgery, University of Leipzig, Leipzig, Germany
    Ann Surg Oncol 16:1222-30. 2009
    ..However, its significance in hepatocellular carcinoma (HCC) is not well established...
  36. doi request reprint [Allocation problems in organ transplantation: practical medical experience]
    Christoph Benckert
    Klinik für Viszeral, Transplantations, Thorax und Gefäßchirurgie Universitätsklinikum Leipzig, Leipzig
    Z Evid Fortbild Qual Gesundhwes 104:397-9. 2010
    ..Finally, continuous review and adaptation will be a persisting challenge for people working in the field of solid organ transplantation...
  37. doi request reprint Tumor-associated angiogenesis and lymphangiogenesis correlate with progression of intrahepatic cholangiocarcinoma
    Armin Thelen
    Department of Visceral, Transplantation, Thoracic and Vascular Surgery, University of Leipzig, Leipzig, Germany
    Am J Gastroenterol 105:1123-32. 2010
    ..This study was conducted to evaluate the influence of tumor-associated angiogenesis and lymphangiogenesis on progression of IHC...
  38. doi request reprint Balanced management of hepatic trauma is associated with low liver-related mortality
    Christoph Benckert
    Division of Visceral, Transplantation, Thoracic and Vascular Surgery, Universitatsklinikum Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany
    Langenbecks Arch Surg 395:381-6. 2010
    ..Hepatic trauma is a rare surgical emergency with significant morbidity and mortality. Therapeutic strategies have been controversially discussed during the last decades...
  39. ncbi request reprint A new anchor electrode design for continuous neuromonitoring of the recurrent laryngeal nerve by vagal nerve stimulations
    Rick Schneider
    Department of Surgery, University Hospital Leipzig, Leipzig, Germany
    Langenbecks Arch Surg 394:903-10. 2009
    ....
  40. ncbi request reprint Microscopic tumor cell dissemination in gastric cancer
    Sven Jonas
    Department of General, Visceral, and Transplantation Surgery, Charite Campus Virchow Klinikum, Humboldt University Berlin, Augustenburger Platz 1, D 13353, Berlin, Germany
    Surg Today 34:101-6. 2004
    ..We herein investigate such dissemination, predominantly restricted to the subserosa, in patients with gastric cancer...
  41. doi request reprint Management of esophageal perforations
    Sven Christian Schmidt
    Department of General, Visceral, and Transplantation Surgery, Charite Campus Virchow Klinikum, Universitatsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany
    Surg Endosc 24:2809-13. 2010
    ..Esophageal perforations remain a life-threatening event requiring rapid diagnosis and treatment. Surgical repair and interventional endoscopic or conservative treatment are the common treatment methods...
  42. ncbi request reprint Heme oxygenase-1 protects human hepatocytes in vitro against warm and cold hypoxia
    Eda Tuzuner
    Department of General, Visceral, and Transplantation Surgery, Universitatsmedizin Berlin, Campus Virchow, Germany
    J Hepatol 41:764-72. 2004
    ..Hepatic injury induced by ischemia/reperfusion following surgery, transplantation, or circulatory shock combined with resuscitation is a major clinical problem...
  43. ncbi request reprint Increasing applicability of liver transplantation for patients with hepatitis B-related liver disease
    Thomas Steinmuller
    Department of General, Visceral, and Transplant Surgery, Charite Campus Virchow, Humboldt University of Berlin, Berlin, Germany
    Hepatology 35:1528-35. 2002
    ..Based on our experience, hepatitis B patients, including those with active viral replication, should not be excluded from liver transplantation...
  44. ncbi request reprint Identification of early antigen BZLF1/ZEBRA protein of Epstein-Barr virus can predict the effectiveness of antiviral treatment in patients with post-transplant lymphoproliferative disease
    Stephan H Oertel
    Hämatologie und Onkologie, Universitätsklinikum Charite Campus Virchow, Humboldt Universitat Berlin, Berlin, Germany
    Br J Haematol 118:1120-3. 2002
    ..Response of PTLD to antiviral treatment correlated with the expression of lytic phase antigen BZLF1/ZEBRA protein, an early antigen of lytic EBV-activity, in the biopsied PTLD specimens...