Peter Jonas

Summary

Affiliation: University of Freiburg
Country: Germany

Publications

  1. ncbi request reprint Synapses formed by normal and abnormal hippocampal mossy fibers
    Michael Frotscher
    Institut für Anatomie und Zellbiologie und Zentrum für Neurowissenschaften, Albert Ludwigs Universitat Freiburg, 79104 Freiburg, Germany
    Cell Tissue Res 326:361-7. 2006
  2. ncbi request reprint Patch-clamp recording from mossy fiber terminals in hippocampal slices
    Josef Bischofberger
    Institute of Physiology, University of Freiburg, Hermann Herder Strasse 7, D 79104 Freiburg, Germany
    Nat Protoc 1:2075-81. 2006
  3. ncbi request reprint Interneuron Diversity series: Fast in, fast out--temporal and spatial signal processing in hippocampal interneurons
    Peter Jonas
    Physiologisches Institut der Universität Freiburg, Hermann Herder Strasse 7, D 79104 Freiburg, Germany
    Trends Neurosci 27:30-40. 2004
  4. doi request reprint Postnatal differentiation of basket cells from slow to fast signaling devices
    Daniel Doischer
    Physiologisches Institut I, Universitat Freiburg, D 79104 Freiburg, Germany
    J Neurosci 28:12956-68. 2008
  5. ncbi request reprint Timing and efficacy of transmitter release at mossy fiber synapses in the hippocampal network
    Josef Bischofberger
    Physiologisches Institut der Universität Freiburg, Hermann Herder Str 7, D 79104, Freiburg, Germany
    Pflugers Arch 453:361-72. 2006
  6. ncbi request reprint Kv3 potassium conductance is necessary and kinetically optimized for high-frequency action potential generation in hippocampal interneurons
    Cheng Chang Lien
    Institute of Physiology, University of Freiburg, D 79104 Freiburg, Germany
    J Neurosci 23:2058-68. 2003
  7. ncbi request reprint Asynchronous GABA release generates long-lasting inhibition at a hippocampal interneuron-principal neuron synapse
    Stefan Hefft
    Physiologisches Institut der Universität Freiburg, Hermann Herder Str 7, D 79104 Freiburg, Germany
    Nat Neurosci 8:1319-28. 2005
  8. ncbi request reprint Timing and efficacy of Ca2+ channel activation in hippocampal mossy fiber boutons
    Josef Bischofberger
    Physiologisches Institut, Universitat Freiburg, D 79104 Freiburg, Germany
    J Neurosci 22:10593-602. 2002
  9. ncbi request reprint Shunting inhibition improves robustness of gamma oscillations in hippocampal interneuron networks by homogenizing firing rates
    Imre Vida
    Anatomisches Institut, Universitat Freiburg, Albertstr 17, D 79104 Freiburg, Germany
    Neuron 49:107-17. 2006
  10. ncbi request reprint Differential gating and recruitment of P/Q-, N-, and R-type Ca2+ channels in hippocampal mossy fiber boutons
    LiYi Li
    Physiologisches Institut der Universität Freiburg, Abteilung I, D 79104 Freiburg, Germany
    J Neurosci 27:13420-9. 2007

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Synapses formed by normal and abnormal hippocampal mossy fibers
    Michael Frotscher
    Institut für Anatomie und Zellbiologie und Zentrum für Neurowissenschaften, Albert Ludwigs Universitat Freiburg, 79104 Freiburg, Germany
    Cell Tissue Res 326:361-7. 2006
    ..Together, the findings reviewed here establish mossy fiber synapses as an important component of inhibitory circuits in the hippocampus...
  2. ncbi request reprint Patch-clamp recording from mossy fiber terminals in hippocampal slices
    Josef Bischofberger
    Institute of Physiology, University of Freiburg, Hermann Herder Strasse 7, D 79104 Freiburg, Germany
    Nat Protoc 1:2075-81. 2006
    ..Presynaptic recordings can be obtained in slices from both rats and mice. Presynaptic recordings can be also obtained in slices from transgenic mice in which terminals are labeled with enhanced green fluorescent protein...
  3. ncbi request reprint Interneuron Diversity series: Fast in, fast out--temporal and spatial signal processing in hippocampal interneurons
    Peter Jonas
    Physiologisches Institut der Universität Freiburg, Hermann Herder Strasse 7, D 79104 Freiburg, Germany
    Trends Neurosci 27:30-40. 2004
  4. doi request reprint Postnatal differentiation of basket cells from slow to fast signaling devices
    Daniel Doischer
    Physiologisches Institut I, Universitat Freiburg, D 79104 Freiburg, Germany
    J Neurosci 28:12956-68. 2008
    ..Thus, late postnatal maturation of BCs enhances coherence in neuronal networks and will thereby contribute to the development of cognitive brain functions...
  5. ncbi request reprint Timing and efficacy of transmitter release at mossy fiber synapses in the hippocampal network
    Josef Bischofberger
    Physiologisches Institut der Universität Freiburg, Hermann Herder Str 7, D 79104, Freiburg, Germany
    Pflugers Arch 453:361-72. 2006
    ..The characteristic properties of the hippocampal mossy fiber synapse may be important for pattern separation and information storage in the dentate gyrus-CA3 cell network...
  6. ncbi request reprint Kv3 potassium conductance is necessary and kinetically optimized for high-frequency action potential generation in hippocampal interneurons
    Cheng Chang Lien
    Institute of Physiology, University of Freiburg, D 79104 Freiburg, Germany
    J Neurosci 23:2058-68. 2003
    ..In conclusion, Kv3 channels are necessary for the FS phenotype of OA interneurons, and several of their gating properties appear to be optimized for high-frequency repetitive activity...
  7. ncbi request reprint Asynchronous GABA release generates long-lasting inhibition at a hippocampal interneuron-principal neuron synapse
    Stefan Hefft
    Physiologisches Institut der Universität Freiburg, Hermann Herder Str 7, D 79104 Freiburg, Germany
    Nat Neurosci 8:1319-28. 2005
    ..Asynchronous release occurs at physiological temperature and with behaviorally relevant stimulation patterns, thus generating long-lasting inhibition in the brain...
  8. ncbi request reprint Timing and efficacy of Ca2+ channel activation in hippocampal mossy fiber boutons
    Josef Bischofberger
    Physiologisches Institut, Universitat Freiburg, D 79104 Freiburg, Germany
    J Neurosci 22:10593-602. 2002
    ..The precise timing and high efficacy of Ca2+ channel activation at this cortical glutamatergic synapse may be important for synchronous transmitter release and temporal information processing...
  9. ncbi request reprint Shunting inhibition improves robustness of gamma oscillations in hippocampal interneuron networks by homogenizing firing rates
    Imre Vida
    Anatomisches Institut, Universitat Freiburg, Albertstr 17, D 79104 Freiburg, Germany
    Neuron 49:107-17. 2006
    ..Thus, shunting inhibition may confer increased robustness to gamma oscillations in the brain...
  10. ncbi request reprint Differential gating and recruitment of P/Q-, N-, and R-type Ca2+ channels in hippocampal mossy fiber boutons
    LiYi Li
    Physiologisches Institut der Universität Freiburg, Abteilung I, D 79104 Freiburg, Germany
    J Neurosci 27:13420-9. 2007
    ..In conclusion, single MFBs coexpress multiple types of Ca2+ channels, which are activated differentially by subthreshold and suprathreshold presynaptic voltage signals...
  11. pmc Hyperpolarization-activated cation channels in fast-spiking interneurons of rat hippocampus
    Yexica Aponte
    Physiologisches Institut, Universitat Freiburg, Hermann Herder Str 7, D 79104 Freiburg, Germany
    J Physiol 574:229-43. 2006
    ..In conclusion, our results suggest that Ih channels are expressed in the somatodendritic region, axon and presynaptic elements of fast-spiking BCs in the hippocampus...
  12. pmc Action potential initiation and propagation in hippocampal mossy fibre axons
    Christoph Schmidt-Hieber
    Physiologisches Institut, Universitat Freiburg, Hermann Herder Str 7, D 79104 Freiburg, Germany
    J Physiol 586:1849-57. 2008
    ..This may be of critical importance to separate dendritic integration of thousands of synaptic inputs from the generation and transmission of a common AP output...
  13. doi request reprint Nanodomain coupling between Ca2+ channels and Ca2+ sensors promotes fast and efficient transmitter release at a cortical GABAergic synapse
    Iancu Bucurenciu
    Physiological Institute I, University of Freiburg, Hermann Herder Strasse 7, D 79104 Freiburg, Germany
    Neuron 57:536-45. 2008
    ..Thus, tight coupling contributes to fast feedforward and feedback inhibition in the hippocampal network...
  14. pmc Efficient Ca2+ buffering in fast-spiking basket cells of rat hippocampus
    Yexica Aponte
    Physiological Institute I, University of Freiburg, Hermann Herder Str 7, D 79104 Freiburg, Germany
    J Physiol 586:2061-75. 2008
    ..These specific buffering properties of BCs will sharpen the time course of local Ca(2+) signals, while prolonging the decay of global Ca(2+) signals...
  15. pmc Differential dependence of phasic transmitter release on synaptotagmin 1 at GABAergic and glutamatergic hippocampal synapses
    Angharad M Kerr
    Physiological Institute I, University of Freiburg, Hermann Herder Strasse 7, D 79104 Freiburg, Germany
    Proc Natl Acad Sci U S A 105:15581-6. 2008
    ..Thus, alternative fast Ca(2+) sensors contribute to synchronous release of the inhibitory transmitter GABA in cortical circuits...
  16. ncbi request reprint Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus
    Christoph Schmidt-Hieber
    Physiologisches Institut der Universität Freiburg, D 79104 Freiburg, Germany
    Nature 429:184-7. 2004
    ..Thus, newly generated neurons express unique mechanisms to facilitate synaptic plasticity, which may be important for the formation of new memories...
  17. ncbi request reprint Presynaptic action potential amplification by voltage-gated Na+ channels in hippocampal mossy fiber boutons
    Dominique Engel
    Physiologisches Institut der Universität Freiburg, Hermann Herder Strasse 7, D 79104 Freiburg, Germany
    Neuron 45:405-17. 2005
    ..Thus, presynaptic and axonal Na(+) channels contribute differentially to mossy fiber synaptic transmission...
  18. ncbi request reprint Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks
    Marlene Bartos
    Physiologisches Institut der Universität Freiburg, Abteilung 1, Hermann Herder Strasse 7, D 79104 Freiburg, Germany
    Nat Rev Neurosci 8:45-56. 2007
    ..Computational analysis further suggests that synaptic specialization turns interneuron networks into robust gamma frequency oscillators...
  19. ncbi request reprint Subthreshold dendritic signal processing and coincidence detection in dentate gyrus granule cells
    Christoph Schmidt-Hieber
    Physiologisches Institut der Universität Freiburg, Abteilung I, D 79104 Freiburg, Germany
    J Neurosci 27:8430-41. 2007
    ..Therefore, the structure of the granule cell dendritic tree may be critically important for precise dendritic signal processing and coincidence detection during hippocampus-dependent memory formation and retrieval...
  20. pmc Fast synaptic inhibition promotes synchronized gamma oscillations in hippocampal interneuron networks
    Marlene Bartos
    Physiologisches Institut and Anatomisches Institut, Universitat Freiburg, D 79104 Freiburg, Germany
    Proc Natl Acad Sci U S A 99:13222-7. 2002
    ..In this model, high coherence and flexibility in frequency control emerge from the combination of synaptic properties, network structure, and electrical coupling...
  21. pmc A large pool of releasable vesicles in a cortical glutamatergic synapse
    Stefan Hallermann
    Physiologisches Institut, Universitat Freiburg, D 79104 Freiburg, Germany
    Proc Natl Acad Sci U S A 100:8975-80. 2003
    ..Thus hippocampal mossy fiber synapses have a vesicular "maxipool." Large pool size and rapid vesicle recycling may underlie the uniquely large extent of activity-dependent plasticity in this synapse...
  22. pmc Gating, modulation and subunit composition of voltage-gated K(+) channels in dendritic inhibitory interneurones of rat hippocampus
    Cheng Chang Lien
    Physiologisches Institut der Universität Freiburg, Hermann Herder Strasse 7, D 79104 Freiburg, Germany
    J Physiol 538:405-19. 2002
    ..2 and Kv4.3 channels. Selective modulation of Kv3.2 channels in OA interneurones by cAMP is likely to be an important factor regulating the activity of dendritic inhibitory cells in principal neurone-interneurone microcircuits...
  23. pmc Presynaptic short-term depression is maintained during regulation of transmitter release at a GABAergic synapse in rat hippocampus
    Stefan Hefft
    Physiologisches Institut der Universität Freiburg, Hermann Herder Str 7, D 79104 Freiburg, Germany
    J Physiol 539:201-8. 2002
    ..In conclusion, different types of presynaptic modulation of inhibitory synaptic transmission converge on a reduction of synaptic strength, while short-term dynamics are largely unchanged...
  24. doi request reprint The two sides of hippocampal mossy fiber plasticity
    Angharad M Kerr
    Physiologisches Institut der Universität Freiburg, Abteilung 1, Hermann Herder Str 7, D 79104 Freiburg, Germany
    Neuron 57:5-7. 2008
    ....
  25. ncbi request reprint Structural determinants of transmission at large hippocampal mossy fiber synapses
    Astrid Rollenhagen
    Institute of Neuroscience and Biophysics INB 3, Research Centre Julich, D 52425 Julich, Germany
    J Neurosci 27:10434-44. 2007
    ..Thus, the mossy fiber bouton differs fundamentally in structure and function from the calyx of Held and other central synapses...
  26. ncbi request reprint TwoB or not twoB: differential transmission at glutamatergic mossy fiber-interneuron synapses in the hippocampus
    Josef Bischofberger
    Physiologisches Institut, Universitat Freiburg, Hermann Herder Str 7, Germany
    Trends Neurosci 25:600-3. 2002
    ..Mossy-fiber-interneuron synapses in the stratum lucidum represent a continuum of functional subtypes, in which the subunit composition of postsynaptic AMPA receptors and NMDA receptors appears to be regulated in a coordinated manner...
  27. pmc Kinetics of Mg2+ unblock of NMDA receptors: implications for spike-timing dependent synaptic plasticity
    Björn M Kampa
    Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Physiol 556:337-45. 2004
    ....
  28. ncbi request reprint Functional conversion between A-type and delayed rectifier K+ channels by membrane lipids
    Dominik Oliver
    Institute of Physiology, University of Freiburg, Hermann Herder Strabetae 7, 79104 Freiburg, Germany
    Science 304:265-70. 2004
    ..The bidirectional control of Kv channel gating by lipids may provide a mechanism for the dynamic regulation of electrical signaling in the nervous system...
  29. ncbi request reprint The most important recent advances in synapse research from my point of view--and what remains to be done
    Michael Frotscher
    Cell Tissue Res 326:203-4. 2006