Frank Jessen

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. ncbi request reprint Sensory gating deficit expressed by a disturbed suppression of the P50 event-related potential in patients with Alzheimer's disease
    F Jessen
    Department of Psychiatry, University of Bonn, Sigmind Freud Str 25, 53105 Bonn, Germany
    Am J Psychiatry 158:1319-21. 2001
  2. ncbi request reprint Amplitude reduction of the mismatch negativity in first-degree relatives of patients with schizophrenia
    F Jessen
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25 53105 Bonn, Germany
    Neurosci Lett 309:185-8. 2001
  3. ncbi request reprint Decrease of N-acetylaspartate in the MTL correlates with cognitive decline of AD patients
    F Jessen
    Department of Psychiatry, University of Bonn, Germany
    Neurology 57:930-2. 2001
  4. ncbi request reprint Encoding and retrieval related cerebral activation in continuous verbal recognition
    F Jessen
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Brain Res Cogn Brain Res 12:199-206. 2001
  5. ncbi request reprint Treatment monitoring and response prediction with proton MR spectroscopy in AD
    F Jessen
    Department of Psychiatry, University of Bonn, Germany
    Neurology 67:528-30. 2006
  6. ncbi request reprint Proton magnetic resonance spectroscopy in subjects at risk for schizophrenia
    Frank Jessen
    Department of Psychiatry, University of Bonn Sigmund Freud Str 25 53105 Bonn, Germany
    Schizophr Res 87:81-8. 2006
  7. ncbi request reprint Volume reduction of the entorhinal cortex in subjective memory impairment
    Frank Jessen
    Department of Psychiatry, University of Bonn, Germany
    Neurobiol Aging 27:1751-6. 2006
  8. doi request reprint Prediction of dementia by subjective memory impairment: effects of severity and temporal association with cognitive impairment
    Frank Jessen
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Arch Gen Psychiatry 67:414-22. 2010
  9. ncbi request reprint Novelty detection and repetition suppression in a passive picture viewing task: a possible approach for the evaluation of neuropsychiatric disorders
    Frank Jessen
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Hum Brain Mapp 17:230-6. 2002
  10. doi request reprint A multicenter (1)H-MRS study of the medial temporal lobe in AD and MCI
    F Jessen
    Department of Psychiatry, University of Bonn, Germany
    Neurology 72:1735-40. 2009

Collaborators

Detail Information

Publications109 found, 100 shown here

  1. ncbi request reprint Sensory gating deficit expressed by a disturbed suppression of the P50 event-related potential in patients with Alzheimer's disease
    F Jessen
    Department of Psychiatry, University of Bonn, Sigmind Freud Str 25, 53105 Bonn, Germany
    Am J Psychiatry 158:1319-21. 2001
    ..In this study, the authors tested whether sensory gating is disturbed in patients with Alzheimer's disease...
  2. ncbi request reprint Amplitude reduction of the mismatch negativity in first-degree relatives of patients with schizophrenia
    F Jessen
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25 53105 Bonn, Germany
    Neurosci Lett 309:185-8. 2001
    ..These results provide first evidence for disturbed sensory memory in relatives of patients with schizophrenia...
  3. ncbi request reprint Decrease of N-acetylaspartate in the MTL correlates with cognitive decline of AD patients
    F Jessen
    Department of Psychiatry, University of Bonn, Germany
    Neurology 57:930-2. 2001
    ..The reduction of NAA/Cr in the MTL represents a correlate of cognitive deterioration in AD, whereas it is of limited use to detect subtle changes over time in clinically stable patients...
  4. ncbi request reprint Encoding and retrieval related cerebral activation in continuous verbal recognition
    F Jessen
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Brain Res Cogn Brain Res 12:199-206. 2001
    ..The results are discussed in relation to current concepts of spatial differentiation of memory function and findings from event-related potentials studies of continuous recognition...
  5. ncbi request reprint Treatment monitoring and response prediction with proton MR spectroscopy in AD
    F Jessen
    Department of Psychiatry, University of Bonn, Germany
    Neurology 67:528-30. 2006
    ..Treatment response was associated with an increase of NAA and NAA/Cr in the parietal lobe. Low baseline NAA/Cr in the parietal lobe predicted positive treatment outcome...
  6. ncbi request reprint Proton magnetic resonance spectroscopy in subjects at risk for schizophrenia
    Frank Jessen
    Department of Psychiatry, University of Bonn Sigmund Freud Str 25 53105 Bonn, Germany
    Schizophr Res 87:81-8. 2006
    ....
  7. ncbi request reprint Volume reduction of the entorhinal cortex in subjective memory impairment
    Frank Jessen
    Department of Psychiatry, University of Bonn, Germany
    Neurobiol Aging 27:1751-6. 2006
    ..The mean volume reduction of the hippocampus was 6% (SMI), 16% (MCI) and 19% (AD). Our results mirror the temporal sequence of neurodegeneration in AD and support the concept of SMI as the first clinical manifestation of dementia...
  8. doi request reprint Prediction of dementia by subjective memory impairment: effects of severity and temporal association with cognitive impairment
    Frank Jessen
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Arch Gen Psychiatry 67:414-22. 2010
    ..Subjective memory impairment (SMI) is receiving increasing attention as a pre-mild cognitive impairment (MCI) condition in the course of the clinical manifestation of Alzheimer disease (AD)...
  9. ncbi request reprint Novelty detection and repetition suppression in a passive picture viewing task: a possible approach for the evaluation of neuropsychiatric disorders
    Frank Jessen
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Hum Brain Mapp 17:230-6. 2002
    ..Our results indicate that activation of disease-relevant brain regions under passive task conditions is possible. This might increase the utility of functional imaging in cognitively impaired patients...
  10. doi request reprint A multicenter (1)H-MRS study of the medial temporal lobe in AD and MCI
    F Jessen
    Department of Psychiatry, University of Bonn, Germany
    Neurology 72:1735-40. 2009
    ..Within the German Competence Network on Dementia, we conducted a (1)H-MRS study in patients with mild dementia and mild cognitive impairment (MCI) at four sites to investigate the multicenter feasibility of (1)H-MRS...
  11. ncbi request reprint Reduced hippocampal activation during encoding and recognition of words in schizophrenia patients
    Frank Jessen
    Department of Psychiatry, University of Bonn, Germany
    Am J Psychiatry 160:1305-12. 2003
    ....
  12. ncbi request reprint [A contribution to the current discussion on anti-dementia drugs in Germany]
    F Jessen
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Universitat Bonn, Sigmund Freud Strasse 25, 53105, Bonn
    Nervenarzt 78:491-2, 494, 496-7. 2007
    ..The authors argue that these issues need to be considered in an in-depth evaluation of acetylcholinesterase inhibitors in the treatment of AD...
  13. doi request reprint Anticholinergic drug use and risk for dementia: target for dementia prevention
    Frank Jessen
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 260:S111-5. 2010
    ..In terms of dementia prevention, centrally acting anticholinergic drugs should be strictly avoided, because of long-term dementia risk increase in addition to acute negative effects on cognition...
  14. doi request reprint No association of the Val66Met polymorphism of the brain-derived neurotrophic factor with hippocampal volume in major depression
    Frank Jessen
    Departments of aPsychiatry bRadiology, University of Bonn, Germany
    Psychiatr Genet 19:99-101. 2009
    ..There was, however, no Val66Met effect on hippocampal volume in either group. To conclude, we did not replicate the Val66Met effect on hippocampal volume in neither patients with major depression nor in healthy participants...
  15. ncbi request reprint Activation of human language processing brain regions after the presentation of random letter strings demonstrated with event-related functional magnetic resonance imaging
    F Jessen
    Department of Psychiatry, University of Bonn, Germany
    Neurosci Lett 270:13-6. 1999
    ..Real words contrasted with random letter strings activated the left angular gyrus, bilateral precuneus and the left posterior cingulate gyrus, which may reflect the access of higher semantic associations...
  16. ncbi request reprint Patterns of subjective memory impairment in the elderly: association with memory performance
    Frank Jessen
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Psychol Med 37:1753-62. 2007
    ..However, SMI is also a predictor for future dementia. Thus, there is a need to identify subtypes of SMI that are particularly related to inferior memory performance and may represent at-risk stages for cognitive decline...
  17. ncbi request reprint Proton MR spectroscopy detects a relative decrease of N-acetylaspartate in the medial temporal lobe of patients with AD
    F Jessen
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Neurology 55:684-8. 2000
    ..The reduction of N-acetylaspartate (NAA) detected by proton MR spectroscopy (1H-MRS) represents a robust but unspecific marker for neuronal loss or dysfunction...
  18. ncbi request reprint The concreteness effect: evidence for dual coding and context availability
    F Jessen
    Department of Psychiatry, University of Bonn, Germany
    Brain Lang 74:103-12. 2000
    ....
  19. doi request reprint Association of SORL1 gene variants with Alzheimer's disease
    Heike Kolsch
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Brain Res 1264:1-6. 2009
    ..Thus, our data support a role of SORL1 polymorphisms in AD...
  20. doi request reprint Is the clock drawing test appropriate for screening for mild cognitive impairment?--Results of the German study on Ageing, Cognition and Dementia in Primary Care Patients (AgeCoDe)
    Lena Ehreke
    Department of Psychiatry, University of Leipzig, Leipzig, Germany
    Dement Geriatr Cogn Disord 28:365-72. 2009
    ..Due to the fact that the Clock Drawing Test (CDT) is widely used to screen for dementia, it is questionable whether it is suited to screen for MCI...
  21. doi request reprint Gene polymorphisms in prodynorphin (PDYN) are associated with episodic memory in the elderly
    Heike Kolsch
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, Bonn 53105, Germany
    J Neural Transm 116:897-903. 2009
    ..Verbal fluency scores were non-significantly better in carriers of these respective alleles. Thus, our results suggest a role of PDYN gene variations in determining memory function also in elderly humans...
  22. doi request reprint Anterior hippocampus orchestrates successful encoding and retrieval of non-relational memory: an event-related fMRI study
    Tilo Kircher
    Department of Psychiatry, RWTH Aachen University Hospital, Pauwelsstr 30, 52074, Aachen, Germany
    Eur Arch Psychiatry Clin Neurosci 258:363-72. 2008
    ..Our results indicate that the anterior left hippocampus plays an important role during successful memory encoding and during successful memory retrieval in a task of simple, non-associative wordlist learning in healthy elderly subjects...
  23. doi request reprint Homocysteine metabolism and cerebrospinal fluid markers for Alzheimer's disease
    Julius Popp
    Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
    J Alzheimers Dis 18:819-28. 2009
    ..The results suggest that alteration of the homocysteine metabolism is related to increased accumulation of phosphorylated tau and may contribute to the neurofibrillary pathology in normal aging and in AD...
  24. doi request reprint Association of N-acetylaspartate and cerebrospinal fluid Aβ42 in dementia
    Frank Jessen
    Department of Psychiatry, University of Bonn, Bonn, Germany
    J Alzheimers Dis 27:393-9. 2011
    ..Since the NAA concentration is coupled to neuronal mitochondrial function, the correlation between NAA and Aβ42 may reflect the interaction between disrupted mitochondrial pathways and amyloid production...
  25. doi request reprint Unipolar depression and hippocampal volume: impact of DNA sequence variants of the glucocorticoid receptor gene
    Astrid Zobel
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Am J Med Genet B Neuropsychiatr Genet 147:836-43. 2008
    ..Unipolar depression is associated with DNA variants of the NR3C1 gene in our population. Neurobiological underpinnings of depression as volumetric reductions of the hippocampus may also be mediated by variants in this gene...
  26. doi request reprint Neural correlates of verbal episodic memory in patients with MCI and Alzheimer's disease--a VBM study
    Dirk T Leube
    Department of Psychiatry, University Hospital Aachen, Pauwelsstrasse 30, Aachen, Germany
    Int J Geriatr Psychiatry 23:1114-8. 2008
    ..Hippocampal atrophy is a hallmark feature of Alzheimer's disease (AD). We used a new and automatized morphometric technique to better characterize brain atrophy in subjects with different levels of cognitive deficit...
  27. doi request reprint CYP46A1 variants influence Alzheimer's disease risk and brain cholesterol metabolism
    Heike Kolsch
    Department of Psychiatry, University of Bonn, Germany
    Eur Psychiatry 24:183-90. 2009
    ..Only few gene variations in CYP46 gene (CYP46A1) have been investigated for their relevance as genetic risk factors of Alzheimer's disease (AD) and results are contradictory...
  28. ncbi request reprint Contribution of apolipoprotein E and cathepsin D genotypes to the familial aggregation of Alzheimer's disease
    Reinhard Heun
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Dement Geriatr Cogn Disord 18:151-8. 2004
    ..The familial aggregation of late-onset Alzheimer's disease (AD) might be caused by the clustering of genetic risk factors in families. This study investigates the influence of variants of candidate genes on the familial aggregation of AD...
  29. doi request reprint Cerebrospinal fluid markers for Alzheimer's disease over the lifespan: effects of age and the APOEε4 genotype
    Julius Popp
    Department of Psychiatry, University of Bonn, Bonn, Germany
    J Alzheimers Dis 22:459-68. 2010
    ..They also suggest that the decrease of Aβ1-42, but not the increase of pTau181 CSF levels is accelerated by the APOEε4 genotype in middle-aged and older adults with normal cognition...
  30. pmc N-acetylaspartylglutamate (NAAG) and N-acetylaspartate (NAA) in patients with schizophrenia
    Frank Jessen
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Schizophr Bull 39:197-205. 2013
    ..The signal of NAAG, however, largely overlaps with its precursor and degrading product N-acetylaspartate (NAA) that by itself does not act in glutamatergic neurotransmission...
  31. doi request reprint Atrophy outcomes in multicentre clinical trials on Alzheimer's disease: effect of different processing and analysis approaches on sample sizes
    Stefan J Teipel
    Department of Psychiatry, University of Rostock, Rostock, Germany
    World J Biol Psychiatry 12:109-13. 2011
    ..The implementation of mixed effects models will enhance the power to detect treatment effects also with other classes of biological endpoints including molecular biomarkers of disease...
  32. doi request reprint CETP polymorphisms influence cholesterol metabolism but not Alzheimer's disease risk
    Homeira Qureischie
    Department of Psychiatry, University of Bonn, Sigmund Freud Strabetae 25, 53105 Bonn, Germany
    Brain Res 1232:1-6. 2008
    ..Our data suggest that CETP gene variations influence cerebral and peripheral cholesterol metabolism, but not AD risk...
  33. pmc Prediction of dementia in primary care patients
    Frank Jessen
    Department of Psychiatry, University of Bonn, Bonn, Germany
    PLoS ONE 6:e16852. 2011
    ..AD prediction tools for primary care are therefore needed. We present a prediction score based on information that can be obtained in the primary care setting...
  34. doi request reprint Volume loss of the medial temporal lobe structures in subjective memory impairment
    Nadine Striepens
    Department of Psychiatry, University of Bonn, Germany
    Dement Geriatr Cogn Disord 29:75-81. 2010
    ..In this study, we determined the volumes of the hippocampus, the entorhinal cortex (EC) and the amygdala to provide biological evidence for AD in SMI...
  35. doi request reprint Influence of SORL1 gene variants: association with CSF amyloid-beta products in probable Alzheimer's disease
    Heike Kolsch
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Neurosci Lett 440:68-71. 2008
    ..15). We found a SORL1 haplotype which was associated with CSF levels of amyloid-beta cleavage products, measured as altered levels of Abeta42. Thus our data suggest that SORL1 gene variants might influence AD pathology...
  36. ncbi request reprint Mild cognitive impairment in general practice: age-specific prevalence and correlate results from the German study on ageing, cognition and dementia in primary care patients (AgeCoDe)
    Tobias Luck
    Department of Psychiatry, University of Leipzig, Leipzig, Germany
    Dement Geriatr Cogn Disord 24:307-16. 2007
    ..Although mild cognitive impairment (MCI) represents a high-risk factor for developing dementia, little is known about the prevalence of MCI among patients of general practitioners (GPs)...
  37. ncbi request reprint A multicenter reproducibility study of single-voxel 1H-MRS of the medial temporal lobe
    Frank Träber
    Department of Radiology, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Eur Radiol 16:1096-103. 2006
    ..This is the basis for applying (1)H-MRS in large-scale early recognition and treatment studies in MTL affecting disorders...
  38. doi request reprint Early and differential diagnosis of dementia and mild cognitive impairment: design and cohort baseline characteristics of the German Dementia Competence Network
    Johannes Kornhuber
    Department of Psychiatry and Psychotherapy, University Erlangen, Erlangen, Germany
    Dement Geriatr Cogn Disord 27:404-17. 2009
    ..The German Dementia Competence Network (DCN) has established procedures for standardized multicenter acquisition of clinical, biological and imaging data, for centralized data management, and for the evaluation of new treatments...
  39. doi request reprint Proton MR spectroscopy of the hippocampus at 3 T in patients with unipolar major depressive disorder: correlates and predictors of treatment response
    Wolfgang Block
    Department of Radiology, University of Bonn, Bonn, Germany
    Int J Neuropsychopharmacol 12:415-22. 2009
    ..This accounts in particular for those patients with low NAA and Cho baseline levels...
  40. doi request reprint RXRA gene variations influence Alzheimer's disease risk and cholesterol metabolism
    Heike Kolsch
    Department of Psychiatry, University of Bonn, Bonn, Germany
    J Cell Mol Med 13:589-98. 2009
    ..009, plasma: P= 0.002; TGC haplotype: CSF: P= 0.019, plasma: P= 0.005). Our results suggest that RXRA gene variants might act as risk factor for AD via an influence on cerebral cholesterol metabolism...
  41. doi request reprint Association of amygdala volumes with cortisol secretion in unipolar depressed patients
    Anna Schuhmacher
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Psychiatry Res 202:96-103. 2012
    ....
  42. doi request reprint Resting-state perfusion in nonmedicated schizophrenic patients: a continuous arterial spin-labeling 3.0-T MR study
    Lukas Scheef
    Department of Radiology, University of Bonn, Sigmund Freud Str 25, Bonn, Germany
    Radiology 256:253-60. 2010
    ..To determine whether well-described patterns of altered perfusion in schizophrenia can be identified by using continuous arterial spin labeling (CASL) with a whole-brain imaging sequence...
  43. doi request reprint Association of the Alzheimer's disease clusterin risk allele with plasma clusterin concentration
    Britta Schürmann
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    J Alzheimers Dis 25:421-4. 2011
    ..011). This effect was numerically also present in the AD patients. We conclude that the rs11136000 AD-risk variant is associated with low clusterin plasma levels...
  44. doi request reprint Multicentre variability of MRI-based medial temporal lobe volumetry in Alzheimer's disease
    Stefan J Teipel
    Department of Psychiatry, University Rostock, Rostock, Germany
    Psychiatry Res 182:244-50. 2010
    ..Our data indicate that multicentre acquisition of MRI data using manual volumetry is reliable and feasible for cross-sectional diagnostic studies, and they replicate essential findings from smaller scale monocentre studies...
  45. doi request reprint DNA sequence variants of the FKBP5 gene are associated with unipolar depression
    Astrid Zobel
    Department of Psychiatry, University of Bonn, Germany
    Int J Neuropsychopharmacol 13:649-60. 2010
    ..Furthermore, several of the investigated SNPs were associated with the disease status and the intermediate phenotype of hippocampal volume...
  46. doi request reprint Alterations of cholesterol precursor levels in Alzheimer's disease
    Heike Kolsch
    Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
    Biochim Biophys Acta 1801:945-50. 2010
    ..These findings raise doubt on a beneficial effect of cholesterol lowering treatment in manifest AD...
  47. ncbi request reprint A comparative study of the different N-acetylaspartate measures of the medial temporal lobe in Alzheimer's disease
    Frank Jessen
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Dement Geriatr Cogn Disord 20:178-83. 2005
    ..To investigate group differences and correlations and to determine the sensitivity and specificity of different measures of the neuronal marker N-acetylaspartate (NAA) in the medial temporal lobe of Alzheimer's Disease (AD) patients...
  48. ncbi request reprint Risk factors and early signs of Alzheimer's disease in a family study sample. Risk of AD
    Reinhard Heun
    Department of Psychiatry, University of Bonn, Venusberg, 53105 Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 256:28-36. 2006
    ....
  49. doi request reprint Risk factors for incident mild cognitive impairment--results from the German Study on Ageing, Cognition and Dementia in Primary Care Patients (AgeCoDe)
    T Luck
    Public Health Research Unit, Department of Psychiatry, University of Leipzig, Leipzig, Germany
    Acta Psychiatr Scand 121:260-72. 2010
    ..To provide age- and gender-specific incidence rates of MCI among elderly general practitioner (GP) patients (75+ years) and to identify risk factors for incident MCI...
  50. ncbi request reprint Polymorphisms of the gene encoding the inflammatory cytokine interleukin-6 determine the magnitude of the increase in soluble interleukin-6 receptor levels in Alzheimer's disease. Results of a pilot study
    Metin Bagli
    Department of Psychiatry, University of Bonn, Venusberg, 53105 Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 253:44-8. 2003
    ..We conclude that plasma and CSF levels of sIL-6R are significantly increased in AD patients and that the magnitude of increase is determined by the IL-6 genotype...
  51. doi request reprint Cerebrospinal fluid soluble amyloid-β protein precursor as a potential novel biomarkers of Alzheimer's disease
    Piotr Lewczuk
    Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen and Friedrich Alexander Universität Erlangen Nürnberg, Erlangen, Germany
    J Alzheimers Dis 28:119-25. 2012
    ..Taken together, the results strongly suggest that CSF sAβPP concentrations may be considered as an extension of already available NDD tools...
  52. doi request reprint Evidence of neuronal compensation during episodic memory in subjective memory impairment
    Susanne Erk
    Department of Psychiatry and Psychotherapy, Division of Mind and Brain Research, Charite Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, Berlin, Germany
    Arch Gen Psychiatry 68:845-52. 2011
    ....
  53. ncbi request reprint CSF cortisol in Alzheimer's disease and mild cognitive impairment
    Julius Popp
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Neurobiol Aging 30:498-500. 2009
    ..001) and to MCI subjects (p=0.002). There was no significant increase of cortisol in MCI subjects compared with controls suggesting that the increase of CSF cortisol is not an early event in the course of AD...
  54. ncbi request reprint Amyloid beta peptide ratio 42/40 but not A beta 42 correlates with phospho-Tau in patients with low- and high-CSF A beta 40 load
    Jens Wiltfang
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    J Neurochem 101:1053-9. 2007
    ..We conclude that the amyloid beta concentration ratio should replace the 'raw' concentrations of corresponding A beta peptides to improve reliability of the neurochemical dementia diagnosis...
  55. doi request reprint Hippocampal surface analysis in subjective memory impairment, mild cognitive impairment and Alzheimer's dementia
    Ralf Tepest
    Department of Psychiatry, University of Cologne, Cologne, Germany
    Dement Geriatr Cogn Disord 26:323-9. 2008
    ..To determine the neuroanatomical basis for the relationship among such states, we assessed surface conformations of the hippocampus in AD, mild cognitive impairment (MCI) and subjective memory impairment (SMI)...
  56. ncbi request reprint APOA1 polymorphism influences risk for early-onset nonfamiliar AD
    Heike Vollbach
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Ann Neurol 58:436-41. 2005
    ..No influence of the +83/84bp polymorphism on the risk for AD was observed. These results suggest that variants of APOA1 might influence the onset and the risk for AD...
  57. ncbi request reprint Regional N-acetylaspartate reduction in the hippocampus detected with fast proton magnetic resonance spectroscopic imaging in patients with Alzheimer disease
    Wolfgang Block
    Department of Radiology, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Arch Neurol 59:828-34. 2002
    ..To detect regional metabolic changes that resemble the expected spatial pattern of neuronal loss in patients with Alzheimer disease (AD)...
  58. ncbi request reprint Mild cognitive impairment (MCI) and actual retrieval performance affect cerebral activation in the elderly
    Reinhard Heun
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Neurobiol Aging 28:404-13. 2007
    ..Activation differences between response categories might reflect success (hits) and effort (misses). Increased retrieval-related activation may be used as early marker in subjects at risk of Alzheimer's disease...
  59. ncbi request reprint Polymorphism in ABCA1 influences CSF 24S-hydroxycholesterol levels but is not a major risk factor of Alzheimer's disease
    Heike Kolsch
    Department of Psychiatry, University of Bonn, 53105 Bonn, Germany
    Int J Mol Med 17:791-4. 2006
    ..Our data support the observation that ABCA1 polymorphisms influence cholesterol metabolism of the brain, but might not act as a major risk factor in AD...
  60. ncbi request reprint Memory deficits in abstinent MDMA (ecstasy) users: neuropsychological evidence of frontal dysfunction
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Bonn, Germany
    J Psychopharmacol 20:373-84. 2006
    ..These results suggest that the memory deficits of MDMA users are not only the result of a temporal or hippocampal dysfunction, but also of a dysfunction of regions within the frontal cortex...
  61. ncbi request reprint Cerebrospinal fluid levels of beta-amyloid(42) in patients with Alzheimer's disease are related to the exon 2 polymorphism of the cathepsin D gene
    Andreas Papassotiropoulos
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Neuroreport 13:1291-4. 2002
    ....
  62. doi request reprint AD dementia risk in late MCI, in early MCI, and in subjective memory impairment
    Frank Jessen
    Department of Psychiatry, University of Bonn, Bonn, Germany German Center for Neurodegenerative Diseases DZNE, Bonn, Germany Electronic address
    Alzheimers Dement 10:76-83. 2014
    ..To compare the risk of developing Alzheimer's disease (AD) dementia in late mild cognitive impairment (LMCI), early MCI (EMCI), and subjective memory impairment (SMI) with normal test performance...
  63. ncbi request reprint Glucose metabolism, gray matter structure, and memory decline in subjective memory impairment
    Lukas Scheef
    Department of Radiology, University of Bonn, Bonn, Germany
    Neurology 79:1332-9. 2012
    ..To identify biological evidence for Alzheimer disease (AD) in individuals with subjective memory impairment (SMI) and unimpaired cognitive performance and to investigate the longitudinal cognitive course in these subjects...
  64. ncbi request reprint Association of an interleukin-1beta gene polymorphism at position -511 with Alzheimer's disease
    Christian Ehl
    Department of Psychiatry, University of Bonn, D 53105 Bonn, Germany
    Int J Mol Med 11:235-8. 2003
    ..Even though IL-1beta -511 polymorphism did not influence the risk of AD it might have a pathophysiological influence on the disease process...
  65. doi request reprint Measurement of ERK 1/2 in CSF from patients with neuropsychiatric disorders and evidence for the presence of the activated form
    Hans Wolfgang Klafki
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    J Alzheimers Dis 18:613-22. 2009
    ....
  66. doi request reprint Long-term stability of Alzheimer's disease biomarker proteins in cerebrospinal fluid
    Carola G Schipke
    Department of Psychiatry, Charite, CBF, Berlin, Germany
    J Alzheimers Dis 26:255-62. 2011
    ..The determination of these biomarkers and potentially new biomarkers in CSF samples stored in large biomaterial banks assembled over many years is feasible...
  67. ncbi request reprint PPARD haplotype influences cholesterol metabolism but is no risk factor of Alzheimer's disease
    Julia Holzapfel
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Neurosci Lett 408:57-61. 2006
    ..8+/-7.7ng/mg; non-carriers: 58.6+/-2.3ng/mg; p=0.002) but not in non-demented controls. Our results suggest that PPARD haplotypes might influence levels of cholesterol metabolites in AD patients, but act not as risk factors of AD...
  68. ncbi request reprint Multiplexed quantification of dementia biomarkers in the CSF of patients with early dementias and MCI: a multicenter study
    Piotr Lewczuk
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Neurobiol Aging 29:812-8. 2008
    ..9 pg/mL. These cutoff values were also applied to discriminate between MCI-AD and MCI-O subjects. Simultaneous measurement of the biomarkers significantly improves management of the samples and quality control of the assays' performance...
  69. doi request reprint Macrophage migration inhibitory factor in mild cognitive impairment and Alzheimer's disease
    Julius Popp
    University of Bonn, Department of Psychiatry, Bonn, Germany
    J Psychiatr Res 43:749-53. 2009
    ..407; p=0.023). These results demonstrate increased MIF production in AD and MCI suggesting that MIF may be involved in the occurring neuroinflammatory process at a clinical pre-dementia disease stage...
  70. doi request reprint Interrelated neuropsychological and anatomical evidence of hippocampal pathology in the at-risk mental state
    R Hurlemann
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Psychol Med 38:843-51. 2008
    ..A crucial question is the extent to which interrelated structural-functional deficits of the hippocampus reflect a vulnerability to schizophrenia, as opposed to the disorder per se...
  71. ncbi request reprint Lifetime depressive and somatic symptoms as preclinical markers of late-onset depression
    Sandra Hein
    Department of Psychiatry, University of Bonn, Venusberg, 53105 Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 253:16-21. 2003
    ..Consequently, we examined lifetime depressive and somatic symptoms with respect to later development of late-onset depression...
  72. doi request reprint Biomarkers for Alzheimer's disease: academic, industry and regulatory perspectives
    Harald Hampel
    Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Johann Wolfgang Goethe University, Heinrich Hoffmann Str 10, 60528 Frankfurt Main, Germany
    Nat Rev Drug Discov 9:560-74. 2010
    ..Biomarkers that achieve these characteristics should enable objective business decisions in portfolio management and facilitate regulatory approval of new therapies...
  73. ncbi request reprint Gene variations in GSTM3 are a risk factor for Alzheimer's disease
    G S Hong
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Neurobiol Aging 30:691-6. 2009
    ..95). The population attributable risk of this haplotype in APOE4-allele non-carriers was 32.2%. Our results suggest that there is a group of AD patients in which variations in metabolism of oxidative stress play an important role...
  74. ncbi request reprint 24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia
    A Papassotiropoulos
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    J Psychiatr Res 36:27-32. 2002
    ..We believe that the CSF concentration of 24S-hydroxycholesterol is altered in AD-related neurodegeneration and thus, CSF 24S-hydroxycholesterol may be a marker for monitoring the onset and progression of the disease...
  75. doi request reprint Soluble amyloid precursor proteins in the cerebrospinal fluid as novel potential biomarkers of Alzheimer's disease: a multicenter study
    P Lewczuk
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Mol Psychiatry 15:138-45. 2010
    ..001), from the patients clinically assessed as having other dementias and supported by NDD untypical for AD. We conclude sAPP alpha and sAPP beta might be regarded as novel promising biomarkers supporting the clinical diagnosis of AD...
  76. ncbi request reprint Response-related fMRI of veridical and false recognition of words
    Reinhard Heun
    Department of Psychiatry, University of Bonn, Sigmund Freud Street 25, Venusberg, 53105 Bonn, Germany
    Eur Psychiatry 19:42-52. 2004
    ..The present study intends to replicate and extend this observation by investigating common and differential activation by veridical and false recognition...
  77. ncbi request reprint Smoking upregulates alpha4beta2* nicotinic acetylcholine receptors in the human brain
    Ullrich Wullner
    Department of Neurology, University Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Neurosci Lett 430:34-7. 2008
    ..The up-regulation of alpha4beta2* nAChR upon chronic nicotine exposure via tobacco smoking incorporates subcortical brain regions which may play an important role in nicotine addiction...
  78. ncbi request reprint Differences of cerebral activation between superior and inferior learners during motor sequence encoding and retrieval
    Reinhard Heun
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Psychiatry Res 132:19-32. 2004
    ..e. success and effort. Further intervention studies are needed to assess whether these interindividual differences are the cause or the consequence of differences in memory performance...
  79. ncbi request reprint Response-related fMRI analysis during encoding and retrieval revealed differences in cerebral activation by retrieval success
    R Heun
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, Venusberg, D 53105, Bonn, Germany
    Psychiatry Res 99:137-50. 2000
    ..Increased activation during false alarms might reflect a source-monitoring deficit or an increased subjective familiarity with distractors that have been most intensively processed in extrastriate visual cortex...
  80. ncbi request reprint Early-onset and late-onset depression are independent of the genetic polymorphism of apolipoprotein E
    A Papassotiropoulos
    Department of Psychiatry, University of Bonn, Germany
    Dement Geriatr Cogn Disord 10:258-61. 1999
    ..Our data do not disconfirm the hypothesis of depression sharing some common pathophysiologic features with AD, however, it seems very unlikely that the APOE genotype will elucidate the assumed common mechanisms...
  81. ncbi request reprint No association between an intronic polymorphism in the presenilin-1 gene and Alzheimer disease in a German population
    M Bagli
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    J Neurol Sci 167:34-6. 1999
    ..Our data do not support an association between the intronic polymorphism of the PS-1 gene and AD and there was no interaction between the PS-1 genotype and apolipoprotein E epsilon4 allele...
  82. ncbi request reprint Alpha-1-antichymotrypsin gene polymorphism and risk for sporadic Alzheimer's disease in a German population
    S G Schwab
    Department of Psychiatry, University of Bonn, Germany
    Dement Geriatr Cogn Disord 10:469-72. 1999
    ..When we analyzed the polymorphism in APOE epsilon4 carriers, no overrepresentation in our AD group could be shown for the ACT*AA genotype carriers. Copyrightz1999S.KargerAG,Basel..
  83. doi request reprint [Therapy of psychological and behavioral symptoms in dementia]
    F Jessen
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Universitatsklinikum Bonn, Bonn, Deutschland
    Nervenarzt 81:815-6, 818-22. 2010
    ..However, recommendations can be given. This review follows the S3 guidelines on dementia published by the German Societies for Psychiatry and Psychotherapy (DGPPN) and Neurology (DGN) which address BPSD extensively...
  84. ncbi request reprint Functional MRI of cerebral activation during encoding and retrieval of words
    R Heun
    Department of Psychiatry, University of Bonn, Germany
    Hum Brain Mapp 8:157-69. 1999
    ..The comparison of event-related activation occurring within one trial block instead of among several trial blocks may significantly improve the performance of memory studies...
  85. ncbi request reprint A family study of Alzheimer disease and early- and late-onset depression in elderly patients
    R Heun
    Department of Psychiatry, University of Bonn, Venusberg, D 53105 Bonn, Germany
    Arch Gen Psychiatry 58:190-6. 2001
    ..The substantial symptomatic overlap between depression and dementia in old age may be explained by common genetic vulnerability factors...
  86. ncbi request reprint Interindividual variation of cerebral activation during encoding and retrieval of words
    R Heun
    Department of Psychiatry, University of Bonn, Venusberg, D 53105 Bonn, Germany
    Eur Psychiatry 15:470-9. 2000
    ..The investigation of these interindividual variations will be an exciting scientific challenge in the near future...
  87. doi request reprint [Comment on the S3 guidelines Dementia by the DGPPN and the DGN from the psychiatric point of view]
    F Jessen
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Universitatsklinikum Bonn
    Fortschr Neurol Psychiatr 78:509-12. 2010
    ..The guidelines provide the foundation for substantial improvement in the management of patients with dementia in Germany...
  88. ncbi request reprint Identical distribution of the alpha 2-macroglobulin pentanucleotide deletion in subjects with Alzheimer disease and controls in a German population
    M Bagli
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Am J Med Genet 96:775-7. 2000
    ..Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:775-777, 2000...
  89. ncbi request reprint Association between an interleukin-6 promoter and 3' flanking region haplotype and reduced Alzheimer's disease risk in a German population
    M Bagli
    Department of Psychiatry and Psychotherapy, Rheinische Friedrich Wilhelms Universitat, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Neurosci Lett 283:109-12. 2000
    ..However, haplotype analysis showed a strong linkage disequilibrium between IL-6vntr and IL-6prom and demonstrated an interaction between IL-6vntr and IL-6prom which modifies AD risk...
  90. ncbi request reprint Inter-rater reliability of family history information on psychiatric disorders in relatives
    U Ptok
    Department of Psychiatry, University of Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 251:279-83. 2001
    ..41-1.00) and any psychiatric disorder (kappa=0.79, 95% CI=0.66-0.91). We concluded that the family history interview is a useful family study instrument that can be applied reliably by different raters for frequent psychiatric disorders...
  91. ncbi request reprint Polymorphism in the cholesterol 24S-hydroxylase gene is associated with Alzheimer's disease
    Heike Kolsch
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Mol Psychiatry 7:899-902. 2002
    ..Our results indicate that the CYP46 gene locus may predispose to AD by increasing the 24S-hydroxycholesterol/cholesterol ratio in the brain...
  92. ncbi request reprint In-vivo proton MR-spectroscopy of the human brain: assessment of N-acetylaspartate (NAA) reduction as a marker for neurodegeneration
    W Block
    Department of Radiology, University of Bonn, Bonn, Germany
    Amino Acids 23:317-23. 2002
    ..The observed regional metabolic alterations reflect the neuronal basis of the characteristic neurological symptoms in AD (dementia) and MND (muscular palsy) and mirrors the disease progress over time...
  93. ncbi request reprint Genetic polymorphism of cathepsin D is strongly associated with the risk for developing sporadic Alzheimer's disease
    A Papassotiropoulos
    Department of Psychiatry, University of Bonn, Germany
    Neurosci Lett 262:171-4. 1999
    ..The odds ratio for subjects with the apolipoprotein E epsilon 4 and the cathepsin D*T allele was 5.9. Our data suggest that the cathepsin D genotype is strongly associated with the risk for Alzheimer's disease...
  94. ncbi request reprint Polymorphism in neuropeptide Y influences CSF cholesterol levels but is no major risk factor of Alzheimer's disease
    H Kolsch
    Department of Psychiatry, University of Bonn, Bonn, Germany
    J Neural Transm 113:231-8. 2006
    ..Both NPY polymorphisms did not influence the risk of AD. Our data support the observation, that NPY polymorphisms might influence cholesterol metabolism, but might not act as major risk factor in AD...
  95. ncbi request reprint Polymorphisms in glutathione S-transferase omega-1 and AD, vascular dementia, and stroke
    H Kolsch
    Department of Psychiatry, University of Bonn, Germany
    Neurology 63:2255-60. 2004
    ..Polymorphisms in GSTO1 might influence the function of the protein and thus the risk of AD, VaD, and stroke...
  96. doi request reprint [Novel neuroimaging perspectives in the diagnosis of dementia]
    F Jessen
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Universitatsklinikum Bonn, Sigmund Freud Strasse 28, 53105, Bonn
    Nervenarzt 79:129-36; quiz 137. 2008
    ....
  97. ncbi request reprint ACE I/D polymorphism is a risk factor of Alzheimer's disease but not of vascular dementia
    H Kolsch
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Neurosci Lett 377:37-9. 2005
    ..Cell-specific effects of ACE polymorphism are suggested, additional studies on neuronal cells might help to understand the role of this polymorphism in AD...
  98. ncbi request reprint [Diagnostic lumbar puncture performed in the outpatient setting of a memory clinic. Frequency and risk factors of post-lumbar puncture headache]
    J Popp
    Diagnostik und Behandlungszentrum für Gedächtniserkrankungen im Alter, Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Rheinische Friedrich Wilhelms Universitat, Sigmund Freud Str 25, 53105, Bonn
    Nervenarzt 78:547-51. 2007
    ..83; CI=0.71-0.97 per year). None of the other factors evaluated proved to be of significant influence. The post-LP symptoms did not necessitate supplementary consultations in any of the cases...
  99. ncbi request reprint A simple and fast method for the preparation of n.c.a. 2-[18F]F-A85380 for human use
    J Schmaljohann
    Department of Nuclear Medicine, University of Bonn, Germany
    Appl Radiat Isot 63:433-5. 2005
    ..After deprotection, adjustment of the pH and sterile filtration n.c.a. 2-[18F]F-A85380 was applicable for the use in human studies with a high specific activity and an overall radiochemical yield of 55% in 35 minutes...
  100. doi request reprint Association of CETP polymorphisms with the risk of vascular dementia and white matter lesions
    H Qureischie
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    J Neural Transm 116:467-72. 2009
    ..009). Our results suggest that CETP gene polymorphisms might influence WML load and the risk of VD, the latter in non-carriers of the APOE4 allele...
  101. ncbi request reprint Multicenter assessment of reliability of cranial MRI
    M Ewers
    Department of Psychiatry, Dementia and Neuroimaging Section, Alzheimer Memorial Center D2, Ludwig Maximilian University of Munich, Nussbaumstr 7, 80336 Munich, Germany
    Neurobiol Aging 27:1051-9. 2006
    ..42) showed that the total sample size needed is N=180. In conclusion, despite minimal inclusion criteria, the reliability of MRI across centers was relatively good...