F Jessen

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. ncbi request reprint [Therapy for patients with dementia. Treatment strategies in the elderly]
    F Jessen
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Universitatsklinikum Bonn, Sigmund Freud Str 25, 53105, Bonn, Deutschland
    Internist (Berl) 55:769-74. 2014
  2. pmc Prediction of dementia in primary care patients
    Frank Jessen
    Department of Psychiatry, University of Bonn, Bonn, Germany
    PLoS ONE 6:e16852. 2011
  3. ncbi request reprint AD dementia risk in late MCI, in early MCI, and in subjective memory impairment
    Frank Jessen
    Department of Psychiatry, University of Bonn, Bonn, Germany German Center for Neurodegenerative Diseases DZNE, Bonn, Germany Electronic address
    Alzheimers Dement 10:76-83. 2014
  4. pmc N-acetylaspartylglutamate (NAAG) and N-acetylaspartate (NAA) in patients with schizophrenia
    Frank Jessen
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Schizophr Bull 39:197-205. 2013
  5. ncbi request reprint Glucose metabolism, gray matter structure, and memory decline in subjective memory impairment
    Lukas Scheef
    Department of Radiology, University of Bonn, Bonn, Germany
    Neurology 79:1332-9. 2012
  6. doi request reprint Association of N-acetylaspartate and cerebrospinal fluid Aβ42 in dementia
    Frank Jessen
    Department of Psychiatry, University of Bonn, Bonn, Germany
    J Alzheimers Dis 27:393-9. 2011
  7. ncbi request reprint [Comment on the S3 guidelines Dementia by the DGPPN and the DGN from the psychiatric point of view]
    F Jessen
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Universitatsklinikum Bonn
    Fortschr Neurol Psychiatr 78:509-12. 2010
  8. ncbi request reprint [Therapy of psychological and behavioral symptoms in dementia]
    F Jessen
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Universitatsklinikum Bonn, Bonn, Deutschland
    Nervenarzt 81:815-6, 818-22. 2010
  9. doi request reprint [Novel neuroimaging perspectives in the diagnosis of dementia]
    F Jessen
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Universitatsklinikum Bonn, Sigmund Freud Strasse 28, 53105, Bonn
    Nervenarzt 79:129-36; quiz 137. 2008
  10. ncbi request reprint Genetic polymorphism of cathepsin D is strongly associated with the risk for developing sporadic Alzheimer's disease
    A Papassotiropoulos
    Department of Psychiatry, University of Bonn, Germany
    Neurosci Lett 262:171-4. 1999

Collaborators

Detail Information

Publications51

  1. ncbi request reprint [Therapy for patients with dementia. Treatment strategies in the elderly]
    F Jessen
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Universitatsklinikum Bonn, Sigmund Freud Str 25, 53105, Bonn, Deutschland
    Internist (Berl) 55:769-74. 2014
    ..The number of patients with dementia is increasing. There is often uncertainty about adequate treatment...
  2. pmc Prediction of dementia in primary care patients
    Frank Jessen
    Department of Psychiatry, University of Bonn, Bonn, Germany
    PLoS ONE 6:e16852. 2011
    ..AD prediction tools for primary care are therefore needed. We present a prediction score based on information that can be obtained in the primary care setting...
  3. ncbi request reprint AD dementia risk in late MCI, in early MCI, and in subjective memory impairment
    Frank Jessen
    Department of Psychiatry, University of Bonn, Bonn, Germany German Center for Neurodegenerative Diseases DZNE, Bonn, Germany Electronic address
    Alzheimers Dement 10:76-83. 2014
    ..To compare the risk of developing Alzheimer's disease (AD) dementia in late mild cognitive impairment (LMCI), early MCI (EMCI), and subjective memory impairment (SMI) with normal test performance...
  4. pmc N-acetylaspartylglutamate (NAAG) and N-acetylaspartate (NAA) in patients with schizophrenia
    Frank Jessen
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Schizophr Bull 39:197-205. 2013
    ..The signal of NAAG, however, largely overlaps with its precursor and degrading product N-acetylaspartate (NAA) that by itself does not act in glutamatergic neurotransmission...
  5. ncbi request reprint Glucose metabolism, gray matter structure, and memory decline in subjective memory impairment
    Lukas Scheef
    Department of Radiology, University of Bonn, Bonn, Germany
    Neurology 79:1332-9. 2012
    ..To identify biological evidence for Alzheimer disease (AD) in individuals with subjective memory impairment (SMI) and unimpaired cognitive performance and to investigate the longitudinal cognitive course in these subjects...
  6. doi request reprint Association of N-acetylaspartate and cerebrospinal fluid Aβ42 in dementia
    Frank Jessen
    Department of Psychiatry, University of Bonn, Bonn, Germany
    J Alzheimers Dis 27:393-9. 2011
    ..Since the NAA concentration is coupled to neuronal mitochondrial function, the correlation between NAA and Aβ42 may reflect the interaction between disrupted mitochondrial pathways and amyloid production...
  7. ncbi request reprint [Comment on the S3 guidelines Dementia by the DGPPN and the DGN from the psychiatric point of view]
    F Jessen
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Universitatsklinikum Bonn
    Fortschr Neurol Psychiatr 78:509-12. 2010
    ..The guidelines provide the foundation for substantial improvement in the management of patients with dementia in Germany...
  8. ncbi request reprint [Therapy of psychological and behavioral symptoms in dementia]
    F Jessen
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Universitatsklinikum Bonn, Bonn, Deutschland
    Nervenarzt 81:815-6, 818-22. 2010
    ..However, recommendations can be given. This review follows the S3 guidelines on dementia published by the German Societies for Psychiatry and Psychotherapy (DGPPN) and Neurology (DGN) which address BPSD extensively...
  9. doi request reprint [Novel neuroimaging perspectives in the diagnosis of dementia]
    F Jessen
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Universitatsklinikum Bonn, Sigmund Freud Strasse 28, 53105, Bonn
    Nervenarzt 79:129-36; quiz 137. 2008
    ....
  10. ncbi request reprint Genetic polymorphism of cathepsin D is strongly associated with the risk for developing sporadic Alzheimer's disease
    A Papassotiropoulos
    Department of Psychiatry, University of Bonn, Germany
    Neurosci Lett 262:171-4. 1999
    ..The odds ratio for subjects with the apolipoprotein E epsilon 4 and the cathepsin D*T allele was 5.9. Our data suggest that the cathepsin D genotype is strongly associated with the risk for Alzheimer's disease...
  11. doi request reprint Association of CETP polymorphisms with the risk of vascular dementia and white matter lesions
    H Qureischie
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    J Neural Transm 116:467-72. 2009
    ..009). Our results suggest that CETP gene polymorphisms might influence WML load and the risk of VD, the latter in non-carriers of the APOE4 allele...
  12. ncbi request reprint Proton MR spectroscopy detects a relative decrease of N-acetylaspartate in the medial temporal lobe of patients with AD
    F Jessen
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Neurology 55:684-8. 2000
    ..The reduction of N-acetylaspartate (NAA) detected by proton MR spectroscopy (1H-MRS) represents a robust but unspecific marker for neuronal loss or dysfunction...
  13. ncbi request reprint Decrease of N-acetylaspartate in the MTL correlates with cognitive decline of AD patients
    F Jessen
    Department of Psychiatry, University of Bonn, Germany
    Neurology 57:930-2. 2001
    ..The reduction of NAA/Cr in the MTL represents a correlate of cognitive deterioration in AD, whereas it is of limited use to detect subtle changes over time in clinically stable patients...
  14. doi request reprint Interaction effects of subjective memory impairment and ApoE4 genotype on episodic memory and hippocampal volume
    N Striepens
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Psychol Med 41:1997-2006. 2011
    ..All participants were ApoE genotyped. 21 subjects with SMI and 47 without received additional structural magnetic resonance imaging. Volumetric measures of the hippocampus, the entorhinal cortex and the amygdala were obtained manually...
  15. ncbi request reprint Alpha-1-antichymotrypsin gene polymorphism and risk for sporadic Alzheimer's disease in a German population
    S G Schwab
    Department of Psychiatry, University of Bonn, Germany
    Dement Geriatr Cogn Disord 10:469-72. 1999
    ..When we analyzed the polymorphism in APOE epsilon4 carriers, no overrepresentation in our AD group could be shown for the ACT*AA genotype carriers. Copyrightz1999S.KargerAG,Basel..
  16. ncbi request reprint Early-onset and late-onset depression are independent of the genetic polymorphism of apolipoprotein E
    A Papassotiropoulos
    Department of Psychiatry, University of Bonn, Germany
    Dement Geriatr Cogn Disord 10:258-61. 1999
    ..Our data do not disconfirm the hypothesis of depression sharing some common pathophysiologic features with AD, however, it seems very unlikely that the APOE genotype will elucidate the assumed common mechanisms...
  17. doi request reprint Amyloid beta peptides in plasma in early diagnosis of Alzheimer's disease: A multicenter study with multiplexing
    P Lewczuk
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Exp Neurol 223:366-70. 2010
    ..Our findings reconfirm the hypothesis that alterations of biomarker concentrations occur early in a preclinical AD stage and that these alterations are also reflected in plasma...
  18. doi request reprint Biomarker validation of a cued recall memory deficit in prodromal Alzheimer disease
    M Wagner
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Neurology 78:379-86. 2012
    ..To compare cued recall measures with other memory and nonmemory tests regarding their association with a biomarker profile indicative of Alzheimer disease (AD) in CSF among patients with mild cognitive impairment (MCI)...
  19. ncbi request reprint Gene variations in GSTM3 are a risk factor for Alzheimer's disease
    G S Hong
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Neurobiol Aging 30:691-6. 2009
    ..95). The population attributable risk of this haplotype in APOE4-allele non-carriers was 32.2%. Our results suggest that there is a group of AD patients in which variations in metabolism of oxidative stress play an important role...
  20. ncbi request reprint Association between an interleukin-6 promoter and 3' flanking region haplotype and reduced Alzheimer's disease risk in a German population
    M Bagli
    Department of Psychiatry and Psychotherapy, Rheinische Friedrich Wilhelms Universitat, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Neurosci Lett 283:109-12. 2000
    ..However, haplotype analysis showed a strong linkage disequilibrium between IL-6vntr and IL-6prom and demonstrated an interaction between IL-6vntr and IL-6prom which modifies AD risk...
  21. ncbi request reprint Response-related fMRI analysis during encoding and retrieval revealed differences in cerebral activation by retrieval success
    R Heun
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, Venusberg, D 53105, Bonn, Germany
    Psychiatry Res 99:137-50. 2000
    ..Increased activation during false alarms might reflect a source-monitoring deficit or an increased subjective familiarity with distractors that have been most intensively processed in extrastriate visual cortex...
  22. ncbi request reprint A combination of galantamine and memantine modifies cognitive function in subjects with amnestic MCI
    O Peters
    Department of Psychiatry, Charite Campus Benjamin Franklin, Berlin, Germany
    J Nutr Health Aging 16:544-8. 2012
    ..One subtype of this syndrome, amnestic MCI, occurs preferentially but not exclusively in prodromal AD and is characterized by defined deficits of episodic memory...
  23. ncbi request reprint No association between an intronic polymorphism in the presenilin-1 gene and Alzheimer disease in a German population
    M Bagli
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    J Neurol Sci 167:34-6. 1999
    ..Our data do not support an association between the intronic polymorphism of the PS-1 gene and AD and there was no interaction between the PS-1 genotype and apolipoprotein E epsilon4 allele...
  24. ncbi request reprint Polymorphism in neuropeptide Y influences CSF cholesterol levels but is no major risk factor of Alzheimer's disease
    H Kolsch
    Department of Psychiatry, University of Bonn, Bonn, Germany
    J Neural Transm 113:231-8. 2006
    ..Both NPY polymorphisms did not influence the risk of AD. Our data support the observation, that NPY polymorphisms might influence cholesterol metabolism, but might not act as major risk factor in AD...
  25. ncbi request reprint Functional MRI of cerebral activation during encoding and retrieval of words
    R Heun
    Department of Psychiatry, University of Bonn, Germany
    Hum Brain Mapp 8:157-69. 1999
    ..The comparison of event-related activation occurring within one trial block instead of among several trial blocks may significantly improve the performance of memory studies...
  26. ncbi request reprint ACE I/D polymorphism is a risk factor of Alzheimer's disease but not of vascular dementia
    H Kolsch
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Neurosci Lett 377:37-9. 2005
    ..Cell-specific effects of ACE polymorphism are suggested, additional studies on neuronal cells might help to understand the role of this polymorphism in AD...
  27. ncbi request reprint Sensory gating deficit expressed by a disturbed suppression of the P50 event-related potential in patients with Alzheimer's disease
    F Jessen
    Department of Psychiatry, University of Bonn, Sigmind Freud Str 25, 53105 Bonn, Germany
    Am J Psychiatry 158:1319-21. 2001
    ..In this study, the authors tested whether sensory gating is disturbed in patients with Alzheimer's disease...
  28. ncbi request reprint A family study of Alzheimer disease and early- and late-onset depression in elderly patients
    R Heun
    Department of Psychiatry, University of Bonn, Venusberg, D 53105 Bonn, Germany
    Arch Gen Psychiatry 58:190-6. 2001
    ..The substantial symptomatic overlap between depression and dementia in old age may be explained by common genetic vulnerability factors...
  29. ncbi request reprint Soluble amyloid precursor proteins in the cerebrospinal fluid as novel potential biomarkers of Alzheimer's disease: a multicenter study
    P Lewczuk
    Department of Psychiatry and Psychotherapy, University of Erlangen Nuremberg, Erlangen, Germany
    Mol Psychiatry 15:138-45. 2010
    ..001), from the patients clinically assessed as having other dementias and supported by NDD untypical for AD. We conclude sAPP alpha and sAPP beta might be regarded as novel promising biomarkers supporting the clinical diagnosis of AD...
  30. doi request reprint Interrelated neuropsychological and anatomical evidence of hippocampal pathology in the at-risk mental state
    R Hurlemann
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Psychol Med 38:843-51. 2008
    ..A crucial question is the extent to which interrelated structural-functional deficits of the hippocampus reflect a vulnerability to schizophrenia, as opposed to the disorder per se...
  31. ncbi request reprint Allelic association between the D10S1423 marker and Alzheimer's disease in a German population
    M Majores
    Department of Psychiatry, University of Bonn, Germany
    Neurosci Lett 289:224-6. 2000
    ..033). In conclusion, our results support that the D10S1423 marker is associated with an increased AD risk and provides further evidence for an AD susceptibility locus on chromosome 10...
  32. doi request reprint A multicenter (1)H-MRS study of the medial temporal lobe in AD and MCI
    F Jessen
    Department of Psychiatry, University of Bonn, Germany
    Neurology 72:1735-40. 2009
    ..Within the German Competence Network on Dementia, we conducted a (1)H-MRS study in patients with mild dementia and mild cognitive impairment (MCI) at four sites to investigate the multicenter feasibility of (1)H-MRS...
  33. ncbi request reprint The concreteness effect: evidence for dual coding and context availability
    F Jessen
    Department of Psychiatry, University of Bonn, Germany
    Brain Lang 74:103-12. 2000
    ....
  34. ncbi request reprint Treatment monitoring and response prediction with proton MR spectroscopy in AD
    F Jessen
    Department of Psychiatry, University of Bonn, Germany
    Neurology 67:528-30. 2006
    ..Treatment response was associated with an increase of NAA and NAA/Cr in the parietal lobe. Low baseline NAA/Cr in the parietal lobe predicted positive treatment outcome...
  35. ncbi request reprint Amplitude reduction of the mismatch negativity in first-degree relatives of patients with schizophrenia
    F Jessen
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25 53105 Bonn, Germany
    Neurosci Lett 309:185-8. 2001
    ..These results provide first evidence for disturbed sensory memory in relatives of patients with schizophrenia...
  36. ncbi request reprint Activation of human language processing brain regions after the presentation of random letter strings demonstrated with event-related functional magnetic resonance imaging
    F Jessen
    Department of Psychiatry, University of Bonn, Germany
    Neurosci Lett 270:13-6. 1999
    ..Real words contrasted with random letter strings activated the left angular gyrus, bilateral precuneus and the left posterior cingulate gyrus, which may reflect the access of higher semantic associations...
  37. ncbi request reprint In-vivo proton MR-spectroscopy of the human brain: assessment of N-acetylaspartate (NAA) reduction as a marker for neurodegeneration
    W Block
    Department of Radiology, University of Bonn, Bonn, Germany
    Amino Acids 23:317-23. 2002
    ..The observed regional metabolic alterations reflect the neuronal basis of the characteristic neurological symptoms in AD (dementia) and MND (muscular palsy) and mirrors the disease progress over time...
  38. ncbi request reprint Encoding and retrieval related cerebral activation in continuous verbal recognition
    F Jessen
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Brain Res Cogn Brain Res 12:199-206. 2001
    ..The results are discussed in relation to current concepts of spatial differentiation of memory function and findings from event-related potentials studies of continuous recognition...
  39. ncbi request reprint Interindividual variation of cerebral activation during encoding and retrieval of words
    R Heun
    Department of Psychiatry, University of Bonn, Venusberg, D 53105 Bonn, Germany
    Eur Psychiatry 15:470-9. 2000
    ..The investigation of these interindividual variations will be an exciting scientific challenge in the near future...
  40. ncbi request reprint Inter-rater reliability of family history information on psychiatric disorders in relatives
    U Ptok
    Department of Psychiatry, University of Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 251:279-83. 2001
    ..41-1.00) and any psychiatric disorder (kappa=0.79, 95% CI=0.66-0.91). We concluded that the family history interview is a useful family study instrument that can be applied reliably by different raters for frequent psychiatric disorders...
  41. ncbi request reprint 24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia
    A Papassotiropoulos
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    J Psychiatr Res 36:27-32. 2002
    ..We believe that the CSF concentration of 24S-hydroxycholesterol is altered in AD-related neurodegeneration and thus, CSF 24S-hydroxycholesterol may be a marker for monitoring the onset and progression of the disease...
  42. ncbi request reprint Multicenter assessment of reliability of cranial MRI
    M Ewers
    Department of Psychiatry, Dementia and Neuroimaging Section, Alzheimer Memorial Center D2, Ludwig Maximilian University of Munich, Nussbaumstr 7, 80336 Munich, Germany
    Neurobiol Aging 27:1051-9. 2006
    ..42) showed that the total sample size needed is N=180. In conclusion, despite minimal inclusion criteria, the reliability of MRI across centers was relatively good...
  43. ncbi request reprint Polymorphisms in glutathione S-transferase omega-1 and AD, vascular dementia, and stroke
    H Kolsch
    Department of Psychiatry, University of Bonn, Germany
    Neurology 63:2255-60. 2004
    ..Polymorphisms in GSTO1 might influence the function of the protein and thus the risk of AD, VaD, and stroke...
  44. ncbi request reprint Identical distribution of the alpha 2-macroglobulin pentanucleotide deletion in subjects with Alzheimer disease and controls in a German population
    M Bagli
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Am J Med Genet 96:775-7. 2000
    ..Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:775-777, 2000...
  45. ncbi request reprint [Diagnostic lumbar puncture performed in the outpatient setting of a memory clinic. Frequency and risk factors of post-lumbar puncture headache]
    J Popp
    Diagnostik und Behandlungszentrum für Gedächtniserkrankungen im Alter, Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Rheinische Friedrich Wilhelms Universitat, Sigmund Freud Str 25, 53105, Bonn
    Nervenarzt 78:547-51. 2007
    ..83; CI=0.71-0.97 per year). None of the other factors evaluated proved to be of significant influence. The post-LP symptoms did not necessitate supplementary consultations in any of the cases...
  46. ncbi request reprint [A contribution to the current discussion on anti-dementia drugs in Germany]
    F Jessen
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Universitat Bonn, Sigmund Freud Strasse 25, 53105, Bonn
    Nervenarzt 78:491-2, 494, 496-7. 2007
    ..The authors argue that these issues need to be considered in an in-depth evaluation of acetylcholinesterase inhibitors in the treatment of AD...
  47. ncbi request reprint Successful treatment of sexual disinhibition in dementia with carbamazepine -- a case report
    N Freymann
    Department of Psychiatry, Friedrich Wilhelms University Bonn, Germany
    Pharmacopsychiatry 38:144-5. 2005
    ..The efficacy of carbamazepine in this case is in parallels to its effects on aggression and agitation in dementia and supports the important role of anticonvulsants in the management of behavioral disturbances in demented patients...
  48. ncbi request reprint A simple and fast method for the preparation of n.c.a. 2-[18F]F-A85380 for human use
    J Schmaljohann
    Department of Nuclear Medicine, University of Bonn, Germany
    Appl Radiat Isot 63:433-5. 2005
    ..After deprotection, adjustment of the pH and sterile filtration n.c.a. 2-[18F]F-A85380 was applicable for the use in human studies with a high specific activity and an overall radiochemical yield of 55% in 35 minutes...
  49. ncbi request reprint KIBRA gene variants are associated with episodic memory in healthy elderly
    K Schaper
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Neurobiol Aging 29:1123-5. 2008
    ..The impact of KIBRA on memory is most likely of high relevance in elderly subjects as it is in young...
  50. ncbi request reprint Polymorphism in the cholesterol 24S-hydroxylase gene is associated with Alzheimer's disease
    Heike Kolsch
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Mol Psychiatry 7:899-902. 2002
    ..Our results indicate that the CYP46 gene locus may predispose to AD by increasing the 24S-hydroxycholesterol/cholesterol ratio in the brain...
  51. ncbi request reprint Validity of the five-item WHO Well-Being Index (WHO-5) in an elderly population
    M Bonsignore
    Department of Psychiatry, University of Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 251:II27-31. 2001
    ..The second version is a stronger scale and was more specific for the detection of depression. The WHO-5 is an useful instrument for identifying elderly subjects with depression...