Alexandra D Jensen

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. pmc Treatment of pediatric patients and young adults with particle therapy at the Heidelberg Ion Therapy Center (HIT): establishment of workflow and initial clinical data
    Stephanie E Combs
    Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, Heidelberg, 69120, Germany
    Radiat Oncol 7:170. 2012
  2. pmc IMRT and carbon ion boost for malignant salivary gland tumors: interim analysis of the COSMIC trial
    Alexandra D Jensen
    Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
    BMC Cancer 12:163. 2012
  3. pmc Radiochemoimmunotherapy with intensity-modulated concomitant boost: interim analysis of the REACH trial
    Alexandra D Jensen
    Dept of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
    Radiat Oncol 7:57. 2012
  4. pmc Robotic-based carbon ion therapy and patient positioning in 6 degrees of freedom: setup accuracy of two standard immobilization devices used in carbon ion therapy and IMRT
    Alexandra D Jensen
    Department of Radiation Oncology, University of Heidelberg, INF 400, Heidelberg 69120, Germany
    Radiat Oncol 7:51. 2012
  5. pmc Review of clinical experience with ion beam radiotherapy
    A D Jensen
    Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
    Br J Radiol 84:S35-47. 2011
  6. doi request reprint Re-irradiation with scanned charged particle beams in recurrent tumours of the head and neck: acute toxicity and feasibility
    Alexandra D Jensen
    Department of Radiation Oncology, Heidelberg, Germany
    Radiother Oncol 101:383-7. 2011
  7. pmc Combined treatment of adenoid cystic carcinoma with cetuximab and IMRT plus C12 heavy ion boost: ACCEPT [ACC, Erbitux® and particle therapy]
    Alexandra D Jensen
    Dept of Radiation Oncology, INF, University of Heidelberg Medical School, Heidelberg, Germany
    BMC Cancer 11:70. 2011
  8. pmc Phase II study of induction chemotherapy with TPF followed by radioimmunotherapy with Cetuximab and intensity-modulated radiotherapy (IMRT) in combination with a carbon ion boost for locally advanced tumours of the oro-, hypopharynx and larynx--TPF-C-HIT
    Alexandra D Jensen
    Dept of Radiation, Oncology INF, Heidelberg Germany
    BMC Cancer 11:182. 2011
  9. pmc Treatment of malignant sinonasal tumours with intensity-modulated radiotherapy (IMRT) and carbon ion boost (C12)
    Alexandra D Jensen
    Dept of Radiation Oncology, INF 400, 69120 Heidelberg, Germany
    BMC Cancer 11:190. 2011
  10. pmc Disease control and functional outcome in three modern combined organ preserving regimens for locally advanced squamous cell carcinoma of the head and neck (SCCHN)
    Alexandra D Jensen
    Dept of Radiation Oncology, INF 400, 69120 Heidelberg, Germany
    Radiat Oncol 6:122. 2011

Detail Information

Publications32

  1. pmc Treatment of pediatric patients and young adults with particle therapy at the Heidelberg Ion Therapy Center (HIT): establishment of workflow and initial clinical data
    Stephanie E Combs
    Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, Heidelberg, 69120, Germany
    Radiat Oncol 7:170. 2012
    ..To report on establishment of workflow and clinical results of particle therapy at the Heidelberg Ion Therapy Center...
  2. pmc IMRT and carbon ion boost for malignant salivary gland tumors: interim analysis of the COSMIC trial
    Alexandra D Jensen
    Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
    BMC Cancer 12:163. 2012
    ....
  3. pmc Radiochemoimmunotherapy with intensity-modulated concomitant boost: interim analysis of the REACH trial
    Alexandra D Jensen
    Dept of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
    Radiat Oncol 7:57. 2012
    ....
  4. pmc Robotic-based carbon ion therapy and patient positioning in 6 degrees of freedom: setup accuracy of two standard immobilization devices used in carbon ion therapy and IMRT
    Alexandra D Jensen
    Department of Radiation Oncology, University of Heidelberg, INF 400, Heidelberg 69120, Germany
    Radiat Oncol 7:51. 2012
    ....
  5. pmc Review of clinical experience with ion beam radiotherapy
    A D Jensen
    Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
    Br J Radiol 84:S35-47. 2011
    ..In view of the limited availability of data, we discuss the necessity to conduct clinical trials. We also look forward towards the next activities to be undertaken at the HIT...
  6. doi request reprint Re-irradiation with scanned charged particle beams in recurrent tumours of the head and neck: acute toxicity and feasibility
    Alexandra D Jensen
    Department of Radiation Oncology, Heidelberg, Germany
    Radiother Oncol 101:383-7. 2011
    ..We report initial toxicity and efficacy of charged particle therapy in this situation...
  7. pmc Combined treatment of adenoid cystic carcinoma with cetuximab and IMRT plus C12 heavy ion boost: ACCEPT [ACC, Erbitux® and particle therapy]
    Alexandra D Jensen
    Dept of Radiation Oncology, INF, University of Heidelberg Medical School, Heidelberg, Germany
    BMC Cancer 11:70. 2011
    ..Radiation sensitization by exploitation of high EGFR-expression in ACC with the EGFR receptor antibody cetuximab seems promising...
  8. pmc Phase II study of induction chemotherapy with TPF followed by radioimmunotherapy with Cetuximab and intensity-modulated radiotherapy (IMRT) in combination with a carbon ion boost for locally advanced tumours of the oro-, hypopharynx and larynx--TPF-C-HIT
    Alexandra D Jensen
    Dept of Radiation, Oncology INF, Heidelberg Germany
    BMC Cancer 11:182. 2011
    ..We expect this approach to result in increased cure rates with yet manageable accompanying toxicity...
  9. pmc Treatment of malignant sinonasal tumours with intensity-modulated radiotherapy (IMRT) and carbon ion boost (C12)
    Alexandra D Jensen
    Dept of Radiation Oncology, INF 400, 69120 Heidelberg, Germany
    BMC Cancer 11:190. 2011
    ..Modern techniques such as IMRT improve toxicity rates while local control remains unchanged. Raster-scanned carbon ion therapy with highly conformal dose distributions may allow higher doses at comparable or reduced side-effects...
  10. pmc Disease control and functional outcome in three modern combined organ preserving regimens for locally advanced squamous cell carcinoma of the head and neck (SCCHN)
    Alexandra D Jensen
    Dept of Radiation Oncology, INF 400, 69120 Heidelberg, Germany
    Radiat Oncol 6:122. 2011
    ....
  11. pmc Raster-scanned carbon ion therapy for malignant salivary gland tumors: acute toxicity and initial treatment response
    Alexandra D Jensen
    Dept Radiation Oncology, University of Heidelberg, INF 400, 69120 Heidelberg, Germany
    Radiat Oncol 6:149. 2011
    ....
  12. pmc Carbon ion therapy for ameloblastic carcinoma
    Alexandra D Jensen
    Dept of Radiation Oncology, INF 400, 69120 Heidelberg, Germany
    Radiat Oncol 6:13. 2011
    ..High dose radiation hence is a potential alternative for patients unfit or unwilling to undergo extensive surgery or in cases when only a subtotal resection is planned or the resection is mutilating...
  13. doi request reprint Combined treatment of nonsmall cell lung cancer NSCLC stage III with intensity-modulated RT radiotherapy and cetuximab: the NEAR trial
    Alexandra D Jensen
    Department of Radiation Oncology, INF 400, Heidelberg, Germany
    Cancer 117:2986-94. 2011
    ..The aim of this study was to evaluate efficacy and toxicity of radioimmunotherapy with intensity-modulated radiation (IMRT) and cetuximab in stage III nonsmall cell lung cancer (NSCLC)...
  14. doi request reprint Catch me if you can--the use of image guidance in the radiotherapy of an unusual case of esophageal cancer
    Alexandra D Jensen
    Department of Radiation Oncology, University of Heidelberg Medical School, Heidelberg, Germany
    Strahlenther Onkol 185:469-73. 2009
    ..New treatment strategies including improved radiation therapy techniques promise better outcome by improving local control through precise dose delivery due to higher conformality...
  15. pmc Combined treatment of malignant salivary gland tumours with intensity-modulated radiation therapy (IMRT) and carbon ions: COSMIC
    Alexandra D Jensen
    Dept, of Radiation Oncology, INF 400, 69120 Heidelberg, Germany
    BMC Cancer 10:546. 2010
    ....
  16. pmc RadioImmunotherapy for adenoid cystic carcinoma: a single-institution series of combined treatment with cetuximab
    Alexandra D Jensen
    Dept of Radiation Oncology, INF 400, 69120 Heidelberg, Germany
    Radiat Oncol 5:102. 2010
    ..This is a single-institution experience of combined radioimmunotherapy (RIT) with the EGFR-inhibitor cetuximab...
  17. pmc Carbon ion therapy for advanced sinonasal malignancies: feasibility and acute toxicity
    Alexandra D Jensen
    Dept of Radiation Oncology INF 400 69120 Heidelberg, Germany
    Radiat Oncol 6:30. 2011
    ..Raster-scanned carbon ion therapy offers the advantage of sharp dose gradients promising increased dose application without increase of side-effects...
  18. pmc Cetuximab and radiation for primary and recurrent squamous cell carcinoma of the head and neck (SCCHN) in the elderly and multi-morbid patient: a single-centre experience
    Alexandra D Jensen
    Dept of Radiation Oncology, Heidelberg, Germany
    Head Neck Oncol 2:34. 2010
    ..Radioimmunotherapy (RIT) with cetuximab provides an option to enhance efficacy of radiotherapy without increased toxicity. We present a single-centre experience of RIT these patients...
  19. doi request reprint Whole-abdominal IMRT for advanced ovarian carcinoma: planning issues and feasibility
    A D Jensen
    Dept of Radiation Oncology, University of Heidelberg Medical School, Germany
    Phys Med 27:194-202. 2011
    ..We intended to demonstrate that whole-abdominal IMRT is feasible and can be used in a routine clinical setting...
  20. doi request reprint Intensity-modulated whole abdominal radiotherapy after surgery and carboplatin/taxane chemotherapy for advanced ovarian cancer: phase I study
    Nathalie Rochet
    Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
    Int J Radiat Oncol Biol Phys 76:1382-9. 2010
    ..To assess the feasibility and toxicity of consolidative intensity-modulated whole abdominal radiotherapy (WAR) after surgery and chemotherapy in high-risk patients with advanced ovarian cancer...
  21. pmc Treatment of locally advanced carcinomas of head and neck with intensity-modulated radiation therapy (IMRT) in combination with cetuximab and chemotherapy: the REACH protocol
    Gregor Habl
    Department of Radiation Oncology, University of Heidelberg, INF 400, 69120 Heidelberg, Germany
    BMC Cancer 10:651. 2010
    ..Radiation therapy (RT) is carried out as intensity-modulated RT (IMRT) to avoid higher grade acute and late toxicity by sparing of surrounding normal tissues...
  22. pmc Randomised trial of proton vs. carbon ion radiation therapy in patients with chordoma of the skull base, clinical phase III study HIT-1-Study
    Anna V Nikoghosyan
    Dept of Clinical Radiology, University of Heidelberg, INF 400, 69120 Heidelberg, Germany
    BMC Cancer 10:607. 2010
    ..Proton therapy is the gold standard in the treatment of skull base chordomas. However, high-LET beams such as carbon ions theoretically offer biologic advantages by enhanced biologic effectiveness in slow-growing tumors...
  23. doi request reprint A clinical concept for interfractional adaptive radiation therapy in the treatment of head and neck cancer
    Alexandra D Jensen
    Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
    Int J Radiat Oncol Biol Phys 82:590-6. 2012
    ..Because of weight loss, treatment plans must be adapted to account for requiring supportive therapy incl. feeding tube or parenteral nutrition without treatment breaks...
  24. pmc Randomised trial of proton vs. carbon ion radiation therapy in patients with low and intermediate grade chondrosarcoma of the skull base, clinical phase III study
    Anna V Nikoghosyan
    Dept of Clinical Radiology, University of Heidelberg, INF 400, 69120 Heidelberg, Germany
    BMC Cancer 10:606. 2010
    ..However, high-LET (linear energy transfer) beams such as carbon ions theoretically offer advantages by enhanced biologic effectiveness in slow-growing tumours...
  25. ncbi request reprint High control rate in patients with chondrosarcoma of the skull base after carbon ion therapy: first report of long-term results
    Matthias Uhl
    Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
    Cancer 120:1579-85. 2014
    ..The current study was performed to evaluate the safety and effectiveness of irradiation with carbon ions using raster scanning as well as prognostic factors in patients with skull base chondrosarcomas...
  26. pmc Adjuvant whole abdominal intensity modulated radiotherapy (IMRT) for high risk stage FIGO III patients with ovarian cancer (OVAR-IMRT-01) - Pilot trial of a phase I/II study: study protocol
    Nathalie Rochet
    Department of Radiation Oncology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    BMC Cancer 7:227. 2007
    ..Modern intensity-modulated radiation therapy (IMRT) could allow to spare kidneys, liver, and bone marrow while still adequately covering the peritoneal cavity with a homogenous dose...
  27. doi request reprint Acute toxicity of combined photon IMRT and carbon ion boost for intermediate-risk prostate cancer - acute toxicity of 12C for PC
    Anna V Nikoghosyan
    Department of Radiation Oncology, University of Heidelberg, Germany
    Acta Oncol 50:784-90. 2011
    ....
  28. pmc Randomized phase II trial of hypofractionated proton versus carbon ion radiation therapy in patients with sacrococcygeal chordoma-the ISAC trial protocol
    Matthias Uhl
    Department of Radiation Oncology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    Radiat Oncol 9:100. 2014
    ..Data of a Japanese study of patients with unresectable sacral chordoma showed comparable high control rates after hypofractionated carbon ion therapy only...
  29. pmc Simultaneous integrated boost for adjuvant treatment of breast cancer--intensity modulated vs. conventional radiotherapy: the IMRT-MC2 trial
    Vasileios Askoxylakis
    Department of Radiation Oncology, University of Heidelberg, INF 400, 69120, Heidelberg, Germany
    BMC Cancer 11:249. 2011
    ..To what extent this might be possible without impairing treatment outcome and cosmetic results remains to be clarified...
  30. doi request reprint Treatment of squamous cell carcinoma of the mobile tongue or tongue margins: an interdisciplinary challenge
    Henrik Hauswald
    Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
    Acta Oncol 52:1017-21. 2013
    ..The present analysis was performed to access outcome and toxicity of radiotherapeutical treatment of squamous cell carcinoma of the tongue...
  31. doi request reprint Application of constant vs. variable relative biological effectiveness in treatment planning of intensity-modulated proton therapy
    Malte C Frese
    Department of Medical Physics in Radiation Oncology, German Cancer Research Center, Heidelberg, Germany
    Int J Radiat Oncol Biol Phys 79:80-8. 2011
    ..1 would result in significant changes in the RBE-weighted dose (RWD) distributions...
  32. pmc Isometric muscle training of the spine musculature in patients with spinal bony metastases under radiation therapy
    Harald Rief
    Dept of Radiation Oncology, INF, University of Heidelberg Medical School, Heidelberg, Germany
    BMC Cancer 11:482. 2011
    ....